<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:tcas="http:///uima/tcas.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:cas="http:///uima/cas.ecore" xmlns:bmi="http:///edu/buffalo/bmi.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="327" language="x-unspecified"/><bmi:JJToken xmi:id="13" sofa="1" begin="0" end="5" Lemma="human" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="69" sofa="1" begin="35" end="43" Lemma="positive" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="101" sofa="1" begin="68" end="82" Lemma="antiretroviral" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="173" sofa="1" begin="133" end="143" Lemma="ineligible" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="285" sofa="1" begin="205" end="215" Lemma="ineligible" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="301" sofa="1" begin="217" end="228" Lemma="appropriate" PossibleAbbreviation="false"/><bmi:JJToken xmi:id="373" sofa="1" begin="290" end="304" Lemma="antiretroviral" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="21" sofa="1" begin="6" end="22" Lemma="immunodeficiency" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="29" sofa="1" begin="23" end="28" Lemma="virus" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="45" sofa="1" begin="30" end="33" Lemma="hiv" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="93" sofa="1" begin="56" end="67" Lemma="combination" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="109" sofa="1" begin="83" end="90" Lemma="therapy" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="149" sofa="1" begin="114" end="117" Lemma="cyp" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="197" sofa="1" begin="148" end="156" Lemma="addition" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="213" sofa="1" begin="158" end="161" Lemma="hiv" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="237" sofa="1" begin="176" end="179" Lemma="cd4" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="245" sofa="1" begin="180" end="185" Lemma="count" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="269" sofa="1" begin="192" end="200" Lemma="cells/ul" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="365" sofa="1" begin="278" end="289" Lemma="combination" PossibleAbbreviation="false"/><bmi:NNToken xmi:id="381" sofa="1" begin="305" end="312" Lemma="therapy" PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="37" sofa="1" begin="29" end="30" Lemma="-lrb-" PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="53" sofa="1" begin="33" end="34" Lemma="-rrb-" PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="61" sofa="1" begin="34" end="35" Lemma="-" PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="181" sofa="1" begin="143" end="144" Lemma=";" PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="205" sofa="1" begin="156" end="157" Lemma="," PossibleAbbreviation="false"/><bmi:PunctToken xmi:id="293" sofa="1" begin="215" end="216" Lemma=";" PossibleAbbreviation="false"/><bmi:NNSToken xmi:id="77" sofa="1" begin="44" end="52" Lemma="patient" PossibleAbbreviation="false"/><bmi:NNSToken xmi:id="157" sofa="1" begin="118" end="128" Lemma="isoenzyme" PossibleAbbreviation="false"/><bmi:NNSToken xmi:id="221" sofa="1" begin="162" end="170" Lemma="patient" PossibleAbbreviation="false"/><bmi:NNSToken xmi:id="309" sofa="1" begin="229" end="236" Lemma="study" PossibleAbbreviation="false"/><bmi:NNSToken xmi:id="349" sofa="1" begin="259" end="267" Lemma="patient" PossibleAbbreviation="false"/><bmi:INToken xmi:id="85" sofa="1" begin="53" end="55" Lemma="on" PossibleAbbreviation="false"/><bmi:INToken xmi:id="141" sofa="1" begin="109" end="113" Lemma="with" PossibleAbbreviation="false"/><bmi:INToken xmi:id="189" sofa="1" begin="145" end="147" Lemma="in" PossibleAbbreviation="false"/><bmi:INToken xmi:id="229" sofa="1" begin="171" end="175" Lemma="with" PossibleAbbreviation="false"/><bmi:INToken xmi:id="341" sofa="1" begin="256" end="258" Lemma="in" PossibleAbbreviation="false"/><bmi:VBNToken xmi:id="117" sofa="1" begin="91" end="96" Lemma="know" PossibleAbbreviation="false"/><bmi:VBNToken xmi:id="333" sofa="1" begin="245" end="255" Lemma="undertake" PossibleAbbreviation="false"/><bmi:VBNToken xmi:id="397" sofa="1" begin="318" end="327" Lemma="indicate" PossibleAbbreviation="false"/><bmi:TOToken xmi:id="125" sofa="1" begin="97" end="99" Lemma="to" PossibleAbbreviation="false"/><bmi:VBToken xmi:id="133" sofa="1" begin="100" end="108" Lemma="interact" PossibleAbbreviation="false"/><bmi:VBToken xmi:id="325" sofa="1" begin="242" end="244" Lemma="be" PossibleAbbreviation="false"/><bmi:VBPToken xmi:id="165" sofa="1" begin="129" end="132" Lemma="be" PossibleAbbreviation="false"/><bmi:VBPToken xmi:id="277" sofa="1" begin="201" end="204" Lemma="be" PossibleAbbreviation="false"/><bmi:JJRToken xmi:id="253" sofa="1" begin="186" end="187" Lemma="&lt;" PossibleAbbreviation="false"/><bmi:CDToken xmi:id="261" sofa="1" begin="188" end="191" Lemma="200" PossibleAbbreviation="false"/><bmi:MDToken xmi:id="317" sofa="1" begin="237" end="241" Lemma="will" PossibleAbbreviation="false"/><bmi:VBGToken xmi:id="357" sofa="1" begin="268" end="277" Lemma="receive" PossibleAbbreviation="false"/><bmi:WRBToken xmi:id="389" sofa="1" begin="313" end="317" Lemma="when" PossibleAbbreviation="false"/><bmi:Sentence xmi:id="405" sofa="1" begin="0" end="327"/><bmi:Dependency xmi:id="425" sofa="1" begin="0" end="28" Governor="29" Dependent="13" Relation="amod"/><bmi:Dependency xmi:id="448" sofa="1" begin="6" end="28" Governor="29" Dependent="21" Relation="compound"/><bmi:Dependency xmi:id="839" sofa="1" begin="23" end="143" Governor="173" Dependent="29" Relation="nsubj"/><bmi:Dependency xmi:id="517" sofa="1" begin="23" end="52" Governor="29" Dependent="77" Relation="dep"/><bmi:Dependency xmi:id="494" sofa="1" begin="23" end="35" Governor="29" Dependent="61" Relation="punct"/><bmi:Dependency xmi:id="471" sofa="1" begin="23" end="33" Governor="29" Dependent="45" Relation="appos"/><bmi:Dependency xmi:id="540" sofa="1" begin="29" end="33" Governor="45" Dependent="37" Relation="punct"/><bmi:Dependency xmi:id="563" sofa="1" begin="30" end="34" Governor="45" Dependent="53" Relation="punct"/><bmi:Dependency xmi:id="586" sofa="1" begin="35" end="52" Governor="77" Dependent="69" Relation="amod"/><bmi:Dependency xmi:id="609" sofa="1" begin="44" end="90" Governor="77" Dependent="109" Relation="nmod"/><bmi:Dependency xmi:id="632" sofa="1" begin="53" end="90" Governor="109" Dependent="85" Relation="case"/><bmi:Dependency xmi:id="655" sofa="1" begin="56" end="90" Governor="109" Dependent="93" Relation="compound"/><bmi:Dependency xmi:id="678" sofa="1" begin="68" end="90" Governor="109" Dependent="101" Relation="amod"/><bmi:Dependency xmi:id="701" sofa="1" begin="83" end="96" Governor="109" Dependent="117" Relation="acl"/><bmi:Dependency xmi:id="724" sofa="1" begin="91" end="108" Governor="117" Dependent="133" Relation="xcomp"/><bmi:Dependency xmi:id="770" sofa="1" begin="97" end="108" Governor="133" Dependent="125" Relation="mark"/><bmi:Dependency xmi:id="747" sofa="1" begin="100" end="128" Governor="133" Dependent="157" Relation="nmod"/><bmi:Dependency xmi:id="793" sofa="1" begin="109" end="128" Governor="157" Dependent="141" Relation="case"/><bmi:Dependency xmi:id="816" sofa="1" begin="114" end="128" Governor="157" Dependent="149" Relation="compound"/><bmi:Dependency xmi:id="885" sofa="1" begin="129" end="143" Governor="173" Dependent="165" Relation="cop"/><bmi:Dependency xmi:id="862" sofa="1" begin="133" end="215" Governor="173" Dependent="285" Relation="parataxis"/><bmi:Dependency xmi:id="908" sofa="1" begin="133" end="144" Governor="173" Dependent="181" Relation="punct"/><bmi:Dependency xmi:id="931" sofa="1" begin="145" end="156" Governor="197" Dependent="189" Relation="case"/><bmi:Dependency xmi:id="1161" sofa="1" begin="148" end="215" Governor="285" Dependent="197" Relation="nmod"/><bmi:Dependency xmi:id="1184" sofa="1" begin="156" end="215" Governor="285" Dependent="205" Relation="punct"/><bmi:Dependency xmi:id="954" sofa="1" begin="158" end="170" Governor="221" Dependent="213" Relation="compound"/><bmi:Dependency xmi:id="1230" sofa="1" begin="162" end="215" Governor="285" Dependent="221" Relation="nsubj"/><bmi:Dependency xmi:id="977" sofa="1" begin="162" end="185" Governor="221" Dependent="245" Relation="nmod"/><bmi:Dependency xmi:id="1000" sofa="1" begin="171" end="185" Governor="245" Dependent="229" Relation="case"/><bmi:Dependency xmi:id="1023" sofa="1" begin="176" end="185" Governor="245" Dependent="237" Relation="compound"/><bmi:Dependency xmi:id="1253" sofa="1" begin="186" end="215" Governor="285" Dependent="253" Relation="dep"/><bmi:Dependency xmi:id="1046" sofa="1" begin="186" end="200" Governor="253" Dependent="269" Relation="dep"/><bmi:Dependency xmi:id="1069" sofa="1" begin="188" end="200" Governor="269" Dependent="261" Relation="nummod"/><bmi:Dependency xmi:id="1115" sofa="1" begin="201" end="215" Governor="285" Dependent="277" Relation="cop"/><bmi:Dependency xmi:id="1092" sofa="1" begin="205" end="327" Governor="285" Dependent="397" Relation="dep"/><bmi:Dependency xmi:id="1207" sofa="1" begin="205" end="255" Governor="285" Dependent="333" Relation="parataxis"/><bmi:Dependency xmi:id="1138" sofa="1" begin="205" end="216" Governor="285" Dependent="293" Relation="punct"/><bmi:Dependency xmi:id="1276" sofa="1" begin="217" end="236" Governor="309" Dependent="301" Relation="amod"/><bmi:Dependency xmi:id="1299" sofa="1" begin="229" end="255" Governor="333" Dependent="309" Relation="nsubjpass"/><bmi:Dependency xmi:id="1322" sofa="1" begin="237" end="255" Governor="333" Dependent="317" Relation="aux"/><bmi:Dependency xmi:id="1345" sofa="1" begin="242" end="255" Governor="333" Dependent="325" Relation="auxpass"/><bmi:Dependency xmi:id="1368" sofa="1" begin="245" end="267" Governor="333" Dependent="349" Relation="nmod"/><bmi:Dependency xmi:id="1391" sofa="1" begin="256" end="267" Governor="349" Dependent="341" Relation="case"/><bmi:Dependency xmi:id="1414" sofa="1" begin="259" end="277" Governor="349" Dependent="357" Relation="acl"/><bmi:Dependency xmi:id="1437" sofa="1" begin="268" end="312" Governor="357" Dependent="381" Relation="dobj"/><bmi:Dependency xmi:id="1460" sofa="1" begin="278" end="312" Governor="381" Dependent="365" Relation="compound"/><bmi:Dependency xmi:id="1483" sofa="1" begin="290" end="312" Governor="381" Dependent="373" Relation="amod"/><bmi:Dependency xmi:id="1506" sofa="1" begin="313" end="327" Governor="397" Dependent="389" Relation="advmod"/><bmi:BioMedicalEntity xmi:id="1513" sofa="1" begin="0" end="28" Terminology="SNOMED" TerminologyIdentifier="230598008####19030005####89293008" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1522" sofa="1" begin="30" end="33" Terminology="SNOMED" TerminologyIdentifier="315124004####226164007####386708005####407515008####181681008####186803007" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1531" sofa="1" begin="35" end="52" Terminology="SNOMED" TerminologyIdentifier="250424006####250423000" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1540" sofa="1" begin="56" end="67" Terminology="SNOMED" TerminologyIdentifier="89780004####228166004" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1549" sofa="1" begin="83" end="90" Terminology="SNOMED" TerminologyIdentifier="170270002####165119001####170297009####360270004####80546007####271421005####169439004####70536003####168523002####129445006####280952003####19030005####12484000####84478008####170184004####170288005####168524008####419815003####170175004####18027006####169438007####69960004####169291001####25162000####398074008####5304008####108290001####170105000####226048001####170112009####243126005####170157000####277132007####273360000####170130002####67101007####413454004####168525009####225738002####169437002####275923005####170308006####416118004####170148006####243931006####263903005####399315003####165127005####170121005####47545007####276239002####391023009####170261000####170139001####266717002####255688002####361226000####408485004####182657004####170166001####170279001" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1558" sofa="1" begin="91" end="96" Terminology="SNOMED" TerminologyIdentifier="36692007####169641007" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1567" sofa="1" begin="114" end="117" Terminology="SNOMED" TerminologyIdentifier="424446007" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1576" sofa="1" begin="118" end="128" Terminology="SNOMED" TerminologyIdentifier="30375003" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1585" sofa="1" begin="129" end="132" Terminology="SNOMED" TerminologyIdentifier="168836005####36070007####258259005####27814009####301183007####159083000####256871003####116680003####88014003####60234000####149016008####58533008####118586006####78494001####263680009####226882008####100832001####160573003####67487000" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1594" sofa="1" begin="148" end="156" Terminology="SNOMED" TerminologyIdentifier="20401003" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1603" sofa="1" begin="158" end="161" Terminology="SNOMED" TerminologyIdentifier="315124004####226164007####386708005####407515008####181681008####186803007" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1612" sofa="1" begin="162" end="170" Terminology="SNOMED" TerminologyIdentifier="360160009####271300009####253620009####45341000####282119004####91251008####396451008####424966008####74036000####87385003####12026006####437871001####41778007####260809006####36682004####84847000####371883000####116154003####103324002" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1621" sofa="1" begin="176" end="185" Terminology="SNOMED" TerminologyIdentifier="313938009" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1630" sofa="1" begin="186" end="187" Terminology="SNOMED" TerminologyIdentifier="276139006####266917007####260313008####264703008" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1639" sofa="1" begin="192" end="200" Terminology="SNOMED" TerminologyIdentifier="258878000" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1648" sofa="1" begin="201" end="204" Terminology="SNOMED" TerminologyIdentifier="168836005####36070007####258259005####27814009####301183007####159083000####256871003####116680003####88014003####60234000####149016008####58533008####118586006####78494001####263680009####226882008####100832001####160573003####67487000" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1657" sofa="1" begin="217" end="228" Terminology="SNOMED" TerminologyIdentifier="185554006####185544007" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1666" sofa="1" begin="229" end="236" Terminology="SNOMED" TerminologyIdentifier="5091004####224699009" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1675" sofa="1" begin="242" end="244" Terminology="SNOMED" TerminologyIdentifier="168836005####36070007####258259005####27814009####301183007####159083000####256871003####116680003####88014003####60234000####149016008####58533008####118586006####78494001####263680009####226882008####100832001####160573003####67487000" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1684" sofa="1" begin="259" end="267" Terminology="SNOMED" TerminologyIdentifier="360160009####271300009####253620009####45341000####282119004####91251008####396451008####424966008####74036000####87385003####12026006####437871001####41778007####260809006####36682004####84847000####371883000####116154003####103324002" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1693" sofa="1" begin="278" end="289" Terminology="SNOMED" TerminologyIdentifier="89780004####228166004" Certainty="affirmed"/><bmi:BioMedicalEntity xmi:id="1702" sofa="1" begin="305" end="327" Terminology="SNOMED" TerminologyIdentifier="183964008####152190007" Certainty="affirmed"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy known to interact with CYP isoenzymes are ineligible; in addition, HIV patients with CD4 count &lt; 200 cells/uL are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated"/><cas:View sofa="1" members="8 13 69 101 173 285 301 373 21 29 45 93 109 149 197 213 237 245 269 365 381 37 53 61 181 205 293 77 157 221 309 349 85 141 189 229 341 117 333 397 125 133 325 165 277 253 261 317 357 389 405 425 448 839 517 494 471 540 563 586 609 632 655 678 701 724 770 747 793 816 885 862 908 931 1161 1184 954 1230 977 1000 1023 1253 1046 1069 1115 1092 1207 1138 1276 1299 1322 1345 1368 1391 1414 1437 1460 1483 1506 1513 1522 1531 1540 1549 1558 1567 1576 1585 1594 1603 1612 1621 1630 1639 1648 1657 1666 1675 1684 1693 1702"/></xmi:XMI>