[9b26b7]: / deepvariant / realigner / window_selector.h

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/*
* Copyright 2017 Google LLC.
*
* Redistribution and use in source and binary forms, with or without
* modification, are permitted provided that the following conditions
* are met:
*
* 1. Redistributions of source code must retain the above copyright notice,
* this list of conditions and the following disclaimer.
*
* 2. Redistributions in binary form must reproduce the above copyright
* notice, this list of conditions and the following disclaimer in the
* documentation and/or other materials provided with the distribution.
*
* 3. Neither the name of the copyright holder nor the names of its
* contributors may be used to endorse or promote products derived from this
* software without specific prior written permission.
*
* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
* AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
* IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
* ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
* LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
* CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
* SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
* INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
* CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
* ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE
* POSSIBILITY OF SUCH DAMAGE.
*/
#ifndef LEARNING_GENOMICS_DEEPVARIANT_REALIGNER_WINDOW_SELECTOR_H_
#define LEARNING_GENOMICS_DEEPVARIANT_REALIGNER_WINDOW_SELECTOR_H_
#include <vector>
#include "deepvariant/allelecounter.h"
#include "deepvariant/protos/realigner.pb.h"
namespace learning {
namespace genomics {
namespace deepvariant {
// Returns a vector of candidate counts for the realigner/window_selector.
//
// This algorithm assumes that the provided AlleleCounter object has had the
// reads we want to use to compute our candidate positions already added to it.
//
// We walk over the AlleleCounts in the AlleleCounter and increment our position
// counts for each non-REFERENCE allele we see as follows:
//
// - SUBSTITITUION: at the substitution position only.
// - DELETE: at positions within [position, position + length)
// - INSERT and CLIP_SOFT: at positions within
// [position - cigar_len, position + cigar_len)
//
// Returns:
// A vector of counts. The value at offset [i] is the sum of candidate
// positions across all alleles in AlleleCount that affected position i.
// The i-th position in this vector corresponding to the i-th position in
// allele_count->Interval(). So result[0] is the count for
// allele_count->Interval().start().
std::vector<int> VariantReadsWindowSelectorCandidates(
const AlleleCounter& allele_counter);
std::vector<float> AlleleCountLinearWindowSelectorCandidates(
const AlleleCounter& allele_counter,
const WindowSelectorModel::AlleleCountLinearModel& config);
} // namespace deepvariant
} // namespace genomics
} // namespace learning
#endif // LEARNING_GENOMICS_DEEPVARIANT_REALIGNER_WINDOW_SELECTOR_H_