[9b26b7]: / deepvariant / realigner / python / ssw_wrap_test.py

Download this file

81 lines (69 with data), 3.2 kB

 1
 2
 3
 4
 5
 6
 7
 8
 9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
# Copyright 2017 Google LLC.
#
# Redistribution and use in source and binary forms, with or without
# modification, are permitted provided that the following conditions
# are met:
#
# 1. Redistributions of source code must retain the above copyright notice,
# this list of conditions and the following disclaimer.
#
# 2. Redistributions in binary form must reproduce the above copyright
# notice, this list of conditions and the following disclaimer in the
# documentation and/or other materials provided with the distribution.
#
# 3. Neither the name of the copyright holder nor the names of its
# contributors may be used to endorse or promote products derived from this
# software without specific prior written permission.
#
# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
# AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
# ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
# LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
# CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
# SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
# INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
# CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
# ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE
# POSSIBILITY OF SUCH DAMAGE.
from absl.testing import absltest
from deepvariant.realigner.python import ssw
REF = 'CAGCCTTTCTGACCCGGAAATCAAAATAGGCACAACAAA'
QUERY = 'CTGAGCCGGTAAATC'
# Expected alignment:
# CAGCCTTTCTGACCCGG-AAATCAAAATAGGCACAACAAA
# ||||*|||| |||||
# CTGAGCCGGTAAATC
class SswWrapTest(absltest.TestCase):
"""Basic tests for the wrapped SSW aligner."""
def test_Align(self):
"""Tests the Align method."""
aligner = ssw.Aligner()
filter_ = ssw.Filter()
length = aligner.set_reference_sequence(REF)
self.assertLen(REF, length)
alignment = aligner.align(QUERY, filter_)
self.assertEqual(21, alignment.sw_score)
self.assertEqual(8, alignment.sw_score_next_best)
self.assertEqual(8, alignment.ref_begin)
self.assertEqual(21, alignment.ref_end)
self.assertEqual(0, alignment.query_begin)
self.assertEqual(14, alignment.query_end)
self.assertEqual(4, alignment.ref_end_next_best)
self.assertEqual(2, alignment.mismatches)
self.assertEqual(b'4=1X4=1I5=', alignment.cigar_string)
def test_Align2_reversed(self):
"""Tests the Align method, reversing query and ref from above."""
aligner = ssw.Aligner()
filter_ = ssw.Filter()
aligner.set_reference_sequence(QUERY)
alignment = aligner.align(REF, filter_)
self.assertEqual(21, alignment.sw_score)
self.assertEqual(8, alignment.query_begin)
self.assertEqual(21, alignment.query_end)
self.assertEqual(0, alignment.ref_begin)
self.assertEqual(14, alignment.ref_end)
self.assertEqual(2, alignment.mismatches)
self.assertEqual(b'8S4=1X4=1D5=17S', alignment.cigar_string)
if __name__ == '__main__':
absltest.main()