| 1 |
35941532 |
10.1186/s10020-022-00518-0 |
2022 |
Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma. |
PTPN6 |
| 2 |
32035162 |
10.1016/j.phrs.2020.104682 |
2021 |
Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells. |
PTPN6 |
| 3 |
32449435 |
10.1080/15476286.2020.1772559 |
2021 |
Burkitt lymphoma-related <i>TCF3</i> mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding. |
PTPN6 |
| 4 |
32732362 |
10.3324/haematol.2020.254276 |
2021 |
Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1. |
PTPN6 |
| 5 |
33290262 |
10.18632/aging.202146 |
2021 |
The improved anticancer effects of Bortezomib-loaded hollow mesoporous silica nanospheres on lymphoma development. |
PTPN6 |
| 6 |
33373915 |
10.1016/j.biopha.2020.111166 |
2021 |
Yishen-tongbi decoction inhibits excessive activation of B cells by activating the FcγRIIb/Lyn/SHP-1 pathway and attenuates the inflammatory response in CIA rats. |
PTPN6 |
| 7 |
33562835 |
10.3390/molecules26040848 |
2021 |
Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2). |
PTPN6 |
| 8 |
30470842 |
10.1038/s41417-018-0057-7 |
2020 |
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma. |
PTPN6 |
| 9 |
32049043 |
10.1016/j.ccell.2020.01.006 |
2020 |
Unraveling the Signaling Balance of Activation and Exhaustion of CAR T Cells. |
PTPN6 |
| 10 |
30420593 |
10.1038/s41408-018-0138-8 |
2019 |
Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma. |
PTPN6 |
| 11 |
29793312 |
10.1016/j.biopha.2017.11.033 |
2018 |
Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia. |
PTPN6 |
| 12 |
29794468 |
10.1159/000490019 |
2018 |
Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma. |
PTPN6 |
| 13 |
29794791 |
10.1097/MD.0000000000010871 |
2018 |
Oncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides. |
PTPN6 |
| 14 |
29925063 |
10.1159/000490106 |
2018 |
Targeting SHP-1, 2 and SHIP Pathways: A Novel Strategy for Cancer Treatment? |
PTPN6 |
| 15 |
26373709 |
10.3109/10428194.2015.1090573 |
2017 |
Expression, prognostic significance and mutational analysis of protein tyrosine phosphatase SHP-1 in chronic myeloid leukemia. |
PTPN6 |
| 16 |
27959415 |
10.3892/or.2016.5308 |
2017 |
Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma. |
PTPN6 |
| 17 |
28031181 |
10.1182/blood-2016-06-722900 |
2017 |
Ibrutinib inhibits pre-BCR<sup>+</sup> B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK. |
PTPN6 |
| 18 |
28210822 |
10.1007/s10147-017-1100-7 |
2017 |
Plasma DNA methylation of p16 and shp1 in patients with B cell non-Hodgkin lymphoma. |
PTPN6 |
| 19 |
25614448 |
10.1158/1078-0432.CCR-14-1216 |
2016 |
Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma. |
PTPN6 |
| 20 |
25951043 |
10.1080/15548627.2015.1017192 |
2016 |
The role of STAT3 in autophagy. |
PTPN6 |
| 21 |
26498513 |
10.3892/or.2015.4347 |
2016 |
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL. |
PTPN6 |
| 22 |
26565811 |
10.18632/oncotarget.6300 |
2016 |
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma. |
PTPN6 |
| 23 |
24952874 |
10.18632/oncotarget.2054 |
2015 |
RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. |
PTPN6 |
| 24 |
25117354 |
10.4238/2014.August.7.11 |
2015 |
Effect of Jianpi Bushen prescription on the expression of SHP-1 and apoptosis-related genes in chemically damaged model mice. |
PTPN6 |
| 25 |
25799995 |
10.1038/nature14231 |
2015 |
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. |
PTPN6 |
| 26 |
26246572 |
10.1128/JVI.01525-15 |
2015 |
Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival. |
PTPN6 |
| 27 |
23979523 |
10.1038/leu.2013.251 |
2014 |
Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy. |
PTPN6 |
| 28 |
24492847 |
10.1101/cshperspect.a014282 |
2014 |
Oncogenic mechanisms in Burkitt lymphoma. |
PTPN6 |
| 29 |
22488585 |
10.1002/hon.2010 |
2013 |
Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma. |
PTPN6 |
| 30 |
22791880 |
10.1158/1078-0432.CCR-12-0101 |
2013 |
Survival signals and targets for therapy in breast implant-associated ALK--anaplastic large cell lymphoma. |
PTPN6 |
| 31 |
22962271 |
10.1158/0008-5472.CAN-12-0939 |
2013 |
Genetic screening for synthetic lethal partners of polynucleotide kinase/phosphatase: potential for targeting SHP-1-depleted cancers. |
PTPN6 |
| 32 |
21818116 |
10.1038/leu.2011.198 |
2012 |
Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1. |
PTPN6 |
| 33 |
21949826 |
10.1371/journal.pone.0024995 |
2012 |
Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation. |
PTPN6 |
| 34 |
19619438 |
|
2011 |
[Effect of As2O3 on demethylation of SHP-1 gene in human lymphoma cell line T2]. |
PTPN6 |
| 35 |
21436254 |
10.1210/me.2010-0486 |
2011 |
B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. |
PTPN6 |
| 36 |
21592569 |
10.1016/j.leukres.2011.04.015 |
2011 |
Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia. |
PTPN6 |
| 37 |
19950550 |
|
2010 |
[As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]. |
PTPN6 |
| 38 |
19965664 |
10.1182/blood-2009-08-237537 |
2010 |
Rituximab inhibits B-cell receptor signaling. |
PTPN6 |
| 39 |
20424160 |
10.1074/jbc.M110.121988 |
2010 |
The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions. |
PTPN6 |
| 40 |
19052984 |
10.1080/10428190802455859 |
2009 |
Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha. |
PTPN6 |
| 41 |
19206008 |
10.1080/08880010802625530 |
2009 |
Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia. |
PTPN6 |
| 42 |
19454653 |
10.1189/jlb.0109037 |
2009 |
Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. |
PTPN6 |
| 43 |
19647218 |
10.1016/j.ccr.2009.07.005 |
2009 |
The SPS affair: a complex tale of illicit proliferation. |
PTPN6 |
| 44 |
19647226 |
10.1016/j.ccr.2009.05.018 |
2009 |
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. |
PTPN6 |
| 45 |
18502033 |
10.1016/j.canlet.2008.04.020 |
2008 |
TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation. |
PTPN6 |
| 46 |
16181557 |
|
2007 |
[Nasal natural killer/T-cell lymphoma genes]. |
PTPN6 |
| 47 |
16389548 |
10.1007/s00109-005-0020-6 |
2007 |
SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasis. |
PTPN6 |
| 48 |
17239936 |
10.1016/j.humpath.2006.09.012 |
2007 |
Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma. |
PTPN6 |
| 49 |
16469875 |
10.1182/blood-2005-06-2421 |
2006 |
SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling. |
PTPN6 |
| 50 |
16825495 |
10.1182/blood-2006-04-017434 |
2006 |
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. |
PTPN6 |
| 51 |
16871283 |
10.1038/sj.leu.2404323 |
2006 |
Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. |
PTPN6 |
| 52 |
15363033 |
10.1111/j.1440-1827.2004.01677.x |
2005 |
SHP-1 expression in primary central nervous system B-cell lymphomas in immunocompetent patients reflects maturation stage of normal B cell counterparts. |
PTPN6 |
| 53 |
15580314 |
10.1038/sj.onc.1208032 |
2005 |
Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors. |
PTPN6 |
| 54 |
15870198 |
10.1073/pnas.0501959102 |
2005 |
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. |
PTPN6 |
| 55 |
14551136 |
10.1182/blood-2003-07-2617 |
2004 |
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. |
PTPN6 |
| 56 |
14614518 |
10.1038/sj.leu.2403216 |
2004 |
SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway. |
PTPN6 |
| 57 |
14624462 |
10.1002/jcb.10727 |
2004 |
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases. |
PTPN6 |
| 58 |
14630083 |
10.1016/s0145-2126(03)00158-9 |
2004 |
Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells. |
PTPN6 |
| 59 |
14691303 |
10.1097/01.lab.0000106503.65258.2b |
2004 |
Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation. |
PTPN6 |
| 60 |
15317731 |
10.1182/blood-2004-03-1151 |
2004 |
Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma. |
PTPN6 |
| 61 |
12591278 |
10.1016/s0301-472x(02)01025-1 |
2003 |
Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis. |
PTPN6 |
| 62 |
12657462 |
10.1016/s0378-1119(03)00400-1 |
2003 |
The function of the protein tyrosine phosphatase SHP-1 in cancer. |
PTPN6 |
| 63 |
11698646 |
10.1073/pnas.231486598 |
2002 |
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. |
PTPN6 |
| 64 |
11832424 |
10.1152/ajprenal.00184.2001 |
2002 |
Altered regulation of SHP-2 and PTP 1B tyrosine phosphatases in cystic kidneys from bcl-2 -/- mice. |
PTPN6 |
| 65 |
12130517 |
10.1182/blood-2001-12-0303 |
2002 |
Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling. |
PTPN6 |
| 66 |
12145687 |
10.1038/sj.leu.2402546 |
2002 |
SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling. |
PTPN6 |
| 67 |
12438221 |
|
2002 |
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. |
PTPN6 |
| 68 |
11157475 |
10.1182/blood.v97.3.608 |
2001 |
SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways. |
PTPN6 |
| 69 |
11340297 |
10.1159/000049187 |
2001 |
Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a. |
PTPN6 |
| 70 |
11420468 |
10.1097/00000478-200107000-00015 |
2001 |
SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts. |
PTPN6 |
| 71 |
11513543 |
10.1006/clim.2001.5082 |
2001 |
Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences. |
PTPN6 |
| 72 |
10609786 |
10.1080/10428199909169613 |
2000 |
Gene expression of the hematopoietic cell phosphatase in juvenile myelomonocytic leukemia. |
PTPN6 |
| 73 |
10617656 |
10.1074/jbc.275.1.599 |
2000 |
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. |
PTPN6 |
| 74 |
10623804 |
10.4049/jimmunol.164.2.631 |
2000 |
Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. |
PTPN6 |
| 75 |
10747947 |
10.1074/jbc.M000689200 |
2000 |
Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. |
PTPN6 |
| 76 |
10914554 |
10.1038/sj.leu.2401822 |
2000 |
The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte colony-stimulating factor (G-CSF) and modulates signaling from the G-CSF receptor. |
PTPN6 |
| 77 |
11021818 |
10.1016/S0002-9440(10)64629-9 |
2000 |
Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. |
PTPN6 |
| 78 |
10072516 |
|
1999 |
Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. |
PTPN6 |
| 79 |
10222053 |
10.1006/cimm.1999.1475 |
1999 |
Bovine leukemia virus transmembrane protein gp30 physically associates with the down-regulatory phosphatase SHP-1. |
PTPN6 |
| 80 |
10228003 |
|
1999 |
CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1. |
PTPN6 |
| 81 |
10229324 |
10.1016/s0145-2126(98)00173-8 |
1999 |
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia. |
PTPN6 |
| 82 |
10382761 |
10.1002/(SICI)1521-4141(199906)29:06<1980::AID-IMMU1980>3.0.CO;2-B |
1999 |
Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase. |
PTPN6 |
| 83 |
10396068 |
10.1007/978-3-642-60162-0_36 |
1999 |
Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation. |
PTPN6 |
| 84 |
10397152 |
10.1016/s0165-2478(99)00026-7 |
1999 |
Cooperation between SHP-2, phosphatidyl inositol 3-kinase and phosphoinositol 5-phosphatase in the Fc gamma RIIb mediated B cell regulation. |
PTPN6 |
| 85 |
10457220 |
10.1046/j.1365-2567.1999.00825.x |
1999 |
H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. |
PTPN6 |
| 86 |
9500795 |
10.1084/jem.187.6.929 |
1998 |
Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. |
PTPN6 |
| 87 |
9670943 |
|
1998 |
B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation. |
PTPN6 |
| 88 |
9743328 |
|
1998 |
Superclustering of B cell receptor and Fc gamma RIIB1 activates Src homology 2-containing protein tyrosine phosphatase-1. |
PTPN6 |
| 89 |
9348315 |
10.1084/jem.186.9.1575 |
1997 |
Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. |
PTPN6 |
| 90 |
9368621 |
10.1002/eji.1830271025 |
1997 |
Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms. |
PTPN6 |
| 91 |
8632004 |
10.1074/jbc.271.7.3856 |
1996 |
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells. |
PTPN6 |
| 92 |
7539038 |
10.1084/jem.181.6.2077 |
1995 |
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. |
PTPN6 |
| 93 |
7657601 |
10.1074/jbc.270.35.20305 |
1995 |
Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation. |
PTPN6 |
| 94 |
8114715 |
10.1128/mcb.14.3.1824-1834.1994 |
1994 |
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. |
PTPN6 |
Datasets
Models
