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1 j
1 J
0 w
10 0 0 10 400.0818 637.9653 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(:::)Tj
/F10 1 Tf
1.8084 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 425.9905 635.4708 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[()]TJ
/F13 1 Tf
(;)Tj
/F10 1 Tf
[( )]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 338.57 694.3748 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.7517 Td
(6)Tj
0 -0.5897 Td
(6)Tj
0 -0.5952 Td
(6)Tj
0 -0.5896 Td
(6)Tj
0 -0.5953 Td
(4)Tj
9.4393 4.1215 Td
(3)Tj
0 -1.7517 Td
(7)Tj
0 -0.5897 Td
(7)Tj
0 -0.5952 Td
(7)Tj
0 -0.5896 Td
(7)Tj
0 -0.5953 Td
(5)Tj
/F10 1 Tf
1.4796 3.5716 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 451.1055 686.3811 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 447.7606 671.9244 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 451.1055 669.4299 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 449.2346 654.9165 cm
BT
/F13 1 Tf
1 TL
0 0 Td
(::)Tj
/F10 1 Tf
-0.0056 -1.6951 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 452.5228 635.4708 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 439.5401 694.3748 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.7517 Td
(6)Tj
0 -0.5897 Td
(6)Tj
0 -0.5952 Td
(6)Tj
0 -0.5896 Td
(6)Tj
0 -0.5953 Td
(4)Tj
1.6724 4.1215 Td
(3)Tj
0 -1.7517 Td
(7)Tj
0 -0.5897 Td
(7)Tj
0 -0.5952 Td
(7)Tj
0 -0.5896 Td
(7)Tj
0 -0.5953 Td
(5)Tj
/F15 1 Tf
10.7205 0.9524 Td
(
)Tj
/F5 1 Tf
(1)Tj
/F15 1 Tf
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/F5 1 Tf
-0.004 Tc
-36.3455 -4.7735 Td
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1.0942 0 Td
(simply,)Tj
/F16 1 Tf
0 Tc
15.5338 -1.8482 Td
[()]TJ
/F15 1 Tf
0.7767 0 Td
()Tj
/F16 1 Tf
1.0488 0 Td
[()]TJ
/F15 1 Tf
17.892 0 Td
(
)Tj
/F5 1 Tf
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/F5 1 Tf
-0.004 Tc
-36.3455 -2.1486 Td
(The)Tj
1.7802 0 Td
(objective)Tj
3.7814 0 Td
(is)Tj
0.8504 0 Td
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1.0261 0 Td
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3.4809 0 Td
(the)Tj
1.4684 0 Td
(mixture)Tj
3.3959 0 Td
(such)Tj
2.0579 0 Td
(that)Tj
1.7801 0 Td
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1.4684 0 Td
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3.3277 0 Td
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(signals)Tj
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1.4457 0 Td
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-31.6004 -1.3039 Td
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1.9389 0 Td
(way)Tj
1.7915 0 Td
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1.0148 0 Td
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2.5342 0 Td
(this)Tj
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1.0261 0 Td
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1.8539 0 Td
(the)Tj
1.4683 0 Td
(mixing)Tj
3.0501 0 Td
(matrix)Tj
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2.8743 0 Td
(M)Tj
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1.1055 0 Td
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2.3867 0 Td
(Independent)Tj
5.3517 0 Td
(Component)Tj
5.0513 0 Td
(Analysis)Tj
-33.9701 -1.2983 Td
(\(ICA\).)Tj
2.812 0 Td
(ICA)Tj
1.9049 0 Td
(can)Tj
1.627 0 Td
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3.1975 0 Td
(source)Tj
2.8346 0 Td
(signals)Tj
2.9027 0 Td
(only)Tj
1.9729 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9219 0 Td
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1.4513 0 Td
(statistically)Tj
4.609 0 Td
(independent.)Tj
5.4992 0 Td
(It)Tj
0.8617 0 Td
(separates)Tj
3.8437 0 Td
(the)Tj
-36.2151 -1.2983 Td
(mixture)Tj
3.3903 0 Td
(by)Tj
1.1848 0 Td
(transforming)Tj
5.4992 0 Td
(it)Tj
0.7824 0 Td
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1.8425 0 Td
(a)Tj
0.6519 0 Td
(linear)Tj
2.5115 0 Td
(combination)Tj
5.3518 0 Td
(of)Tj
1.0148 0 Td
(components)Tj
5.1703 0 Td
(that)Tj
1.7801 0 Td
(are)Tj
1.4513 0 Td
(as)Tj
1.0148 0 Td
(non-Gaussian)Tj
-31.6457 -1.3039 Td
(as)Tj
1.0148 0 Td
(possible.)Tj
3.634 0 Td
(However,)Tj
4.0762 0 Td
(the)Tj
1.4684 0 Td
(assumption)Tj
4.8642 0 Td
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1.0148 0 Td
(independency)Tj
5.8563 0 Td
(among)Tj
2.9933 0 Td
(sources)Tj
3.1918 0 Td
(is)Tj
0.8504 0 Td
(precarious)Tj
4.422 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
-32.1899 -1.2982 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(problem)Tj
3.6113 0 Td
(of)Tj
1.0148 0 Td
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2.1316 0 Td
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2.8006 0 Td
(deconvolution,)Tj
6.2362 0 Td
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3.1918 0 Td
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1.4512 0 Td
(the)Tj
1.4684 0 Td
(original)Tj
3.3278 0 Td
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2.4888 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
-33.2275 -1.2983 Td
(observed)Tj
3.7928 0 Td
(signals)Tj
2.9026 0 Td
(are)Tj
1.4514 0 Td
(the)Tj
1.4683 0 Td
(stain)Tj
2.1316 0 Td
(mixture.)Tj
3.617 0 Td
(Therefore,)Tj
4.3937 0 Td
(we)Tj
1.3266 0 Td
(can)Tj
1.6271 0 Td
(show)Tj
2.2959 0 Td
(the)Tj
1.4684 0 Td
(dependency)Tj
5.0399 0 Td
(between)Tj
3.532 0 Td
(differ-)Tj
-35.0473 -1.3039 Td
(ent)Tj
1.4911 0 Td
(stain)Tj
2.1259 0 Td
(colours)Tj
3.1635 0 Td
(by)Tj
1.1848 0 Td
(comparing)Tj
4.5695 0 Td
(stain)Tj
2.1316 0 Td
(vector)Tj
2.6986 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(stain)Tj
2.1259 0 Td
(using)Tj
2.3924 0 Td
(two)Tj
1.7064 0 Td
(different)Tj
3.6567 0 Td
(staining)Tj
3.4129 0 Td
(contexts:)Tj
-33.7037 -1.2983 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.4741 0 Td
(first)Tj
1.8028 0 Td
(context,)Tj
3.4129 0 Td
(only)Tj
1.9729 0 Td
(one)Tj
1.7007 0 Td
(stain)Tj
2.126 0 Td
(colour)Tj
2.8063 0 Td
(is)Tj
0.8447 0 Td
(applied,)Tj
3.3789 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(second)Tj
3.0103 0 Td
(context)Tj
3.1861 0 Td
(two)Tj
1.7121 0 Td
(stain)Tj
2.126 0 Td
(colours)Tj
3.1634 0 Td
(are)Tj
-36.3285 -1.2982 Td
(applied)Tj
3.1522 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(tissue)Tj
2.4605 0 Td
(as)Tj
1.0148 0 Td
(shown)Tj
2.8459 0 Td
(in)Tj
1.0375 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8482 0 Td
(and)Tj
1.7348 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0749 0 Td
(It)Tj
0.8561 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(shown)Tj
2.8459 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(estimated)Tj
4.0761 0 Td
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2.126 0 Td
(vec-)Tj
-35.4838 -1.2983 Td
(tor)Tj
1.3947 0 Td
(for)Tj
1.3889 0 Td
(slide)Tj
2.041 0 Td
(with)Tj
2.0012 0 Td
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1.9729 0 Td
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1.7008 0 Td
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1.3607 0 Td
(either)Tj
2.5284 0 Td
(H)Tj
0.9922 0 Td
(or)Tj
1.0941 0 Td
(E)Tj
0.7937 0 Td
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0.8447 0 Td
(different)Tj
3.6566 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(corresponding)Tj
-30.6026 -1.3039 Td
(stain)Tj
2.126 0 Td
(vector)Tj
2.6986 0 Td
(estimated)Tj
4.0762 0 Td
(from)Tj
2.2053 0 Td
(slides)Tj
2.4038 0 Td
(with)Tj
2.0012 0 Td
(multiple)Tj
3.566 0 Td
(stains,)Tj
2.7156 0 Td
(for)Tj
1.3833 0 Td
(example)Tj
3.5488 0 Td
(H&E.)Tj
2.4888 0 Td
(Therefore,)Tj
4.3937 0 Td
(stain)Tj
2.126 0 Td
(col-)Tj
-35.7333 -1.2983 Td
(ours)Tj
1.9843 0 Td
(are)Tj
1.4513 0 Td
(actually)Tj
3.2825 0 Td
(not)Tj
1.5761 0 Td
(independent)Tj
5.2724 0 Td
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1.0148 0 Td
(each)Tj
2.0296 0 Td
(other)Tj
2.347 0 Td
(and)Tj
1.7292 0 Td
(presence)Tj
3.7132 0 Td
(of)Tj
1.0148 0 Td
(one)Tj
1.7008 0 Td
(stain)Tj
2.126 0 Td
(affect)Tj
2.3754 0 Td
(the)Tj
1.474 0 Td
(others.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 377.0078 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Sub-band)Tj
4.5023 0 Td
(Independent)Tj
5.7072 0 Td
(Component)Tj
5.3339 0 Td
(Analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 360 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(order)Tj
2.4207 0 Td
(to)Tj
1.0262 0 Td
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2.9196 0 Td
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5.8507 0 Td
(between)Tj
3.5319 0 Td
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(signals,)Tj
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(a)Tj
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3.3959 0 Td
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(such)Tj
2.0579 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
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5.2781 0 Td
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3.2882 0 Td
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1.0261 0 Td
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1.8935 0 Td
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3.668 0 Td
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1.338 0 Td
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(that,)Tj
2.0012 0 Td
(consider)Tj
/F11 1 Tf
3.651 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 260.3338 332.3338 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 266.4 333.9779 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(as)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(observation)Tj
4.8982 0 Td
(signals)Tj
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(after)Tj
2.0353 0 Td
(applying)Tj
3.668 0 Td
(a)Tj
0.6577 0 Td
(filtering)Tj
3.3902 0 Td
(operator)Tj
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3.651 0 Td
[()]TJ
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(,)Tj
0.9637 0 Td
(i.e.)Tj
/F16 1 Tf
0 Tc
-15.0292 -1.8481 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 366.4062 313.0015 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 373.1527 315.496 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F10 1 Tf
1.0488 0 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
(
)Tj
/F16 1 Tf
[()]TJ
/F15 1 Tf
()Tj
17.4102 0 Td
(
)Tj
/F5 1 Tf
(3)Tj
/F15 1 Tf
()Tj
/F5 1 Tf
-0.004 Tc
-35.1492 -2.2506 Td
(Since)Tj
/F11 1 Tf
2.3584 0 Td
(s)Tj
/F5 1 Tf
0.6066 0 Td
(is)Tj
0.8447 0 Td
(linear)Tj
2.5115 0 Td
(combination)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(independent)Tj
5.278 0 Td
(components)Tj
5.1703 0 Td
(and)Tj
/F11 1 Tf
1.7348 0 Td
(M)Tj
/F5 1 Tf
1.0998 0 Td
(is)Tj
0.8504 0 Td
(constant)Tj
3.634 0 Td
(matrix.)Tj
3.1011 0 Td
(Then,)Tj
-34.7468 -1.2983 Td
(we)Tj
1.3266 0 Td
(can)Tj
1.6271 0 Td
(similarly)Tj
3.685 0 Td
(express)Tj
/F11 1 Tf
3.1465 0 Td
(x)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 302.57 278.3055 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 308.6362 280.0062 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(as)Tj
1.0147 0 Td
(follows,)Tj
/F16 1 Tf
0 Tc
-1.2244 -1.8481 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 311.5275 258.9732 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 318.274 261.5244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F10 1 Tf
1.0488 0 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
(
)Tj
/F16 1 Tf
[()]TJ
/F15 1 Tf
()Tj
1.4173 0 Td
()Tj
/F10 1 Tf
1.0488 0 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
(
)Tj
/F17 1 Tf
(Ms)Tj
/F15 1 Tf
()Tj
2.5738 0 Td
()Tj
/F16 1 Tf
1.0488 0 Td
[()]TJ
/F10 1 Tf
[()]TJ
/F15 1 Tf
1.457 0 Td
(
)Tj
/F16 1 Tf
[()]TJ
/F15 1 Tf
()Tj
1.423 0 Td
()Tj
/F16 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 452.9763 258.9732 cm
BT
/F10 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 563.4708 261.5244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(
)Tj
/F5 1 Tf
(4)Tj
/F15 1 Tf
()Tj
/F5 1 Tf
-0.004 Tc
-35.1493 -2.2506 Td
(Thus,)Tj
2.4774 0 Td
(by)Tj
1.1792 0 Td
(applying)Tj
3.6737 0 Td
(ICA)Tj
1.9049 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(filtered)Tj
3.067 0 Td
(observations)Tj
/F11 1 Tf
5.2611 0 Td
(x)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 417.3165 237.3165 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 421.1716 239.0173 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(we)Tj
1.3322 0 Td
(can)Tj
1.6214 0 Td
(find)Tj
1.8539 0 Td
(the)Tj
1.4683 0 Td
(mixing)Tj
3.0557 0 Td
(matrix)Tj
/F11 1 Tf
2.8744 0 Td
(M)Tj
/F5 1 Tf
-34.7638 -1.3039 Td
(which)Tj
2.6419 0 Td
(is)Tj
0.8447 0 Td
(the)Tj
1.4626 0 Td
(same)Tj
2.2507 0 Td
(matrix)Tj
2.8687 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0148 0 Td
(mix)Tj
1.7688 0 Td
(the)Tj
1.4627 0 Td
(raw)Tj
1.7008 0 Td
(signals.)Tj
3.1237 0 Td
(Therefore,)Tj
4.3879 0 Td
(we)Tj
1.321 0 Td
(can)Tj
1.6214 0 Td
(apply)Tj
/F11 1 Tf
2.3811 0 Td
(M)Tj
/F5 1 Tf
1.0941 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.4627 0 Td
(original)Tj
-34.486 -1.2982 Td
(data)Tj
1.9105 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Eq)Tj
1.2983 0 Td
(\(2\))Tj
0 g
1.3719 0 Td
(to)Tj
1.0262 0 Td
(separate)Tj
3.4865 0 Td
(the)Tj
1.4684 0 Td
(mixture)Tj
3.3902 0 Td
(and)Tj
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