--- a +++ b/man/data-validateExp.Rd @@ -0,0 +1,34 @@ +\name{validateExp} +\alias{validateExp} +\docType{data} +\title{ +Data of the validation drug sensitivity screen using five additional drugs +} +\description{ + +To validate some of the associations observed in the main screen, +including the associations between IGHV status and HSP90 inhibitors +and the associations between trisomy 12 and MEK/ERK pathway inhibitors, +the effect of five additional drugs, cobimetinib (MEK inhibitor), +trametinib (MEK inhibitor), SCH772984 (ERK inhibitor), Ganetespib +(HSP90 inhibitor) and Onalespib (HSP90 inhibitor) were tested on 128 CLL +samples that were also used in the main screen. + +The results were stored in a tidy table (tibble) with four columns: + +1) 'patientID' - The patient identifiers. + +2) 'Drug' - The names of the drugs used in this screen. + +3) 'Concentration' - The concentrations of the drugs in the unit of uM. + +4) 'viab' - Viabilities of the samples after drug treatment, normalized by negative controls (DMSO). +} +\author{Junyan Lu} +\usage{ +validateExp +} +\format{ +Tidy table with 3200 rows and 4 columns. +} +\keyword{datasets}