The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway [goid 6281] [pmid 12773567] [evidence NAS]; A process that directly activates any of the steps required for cell death by apoptosis [goid 6917] [pmid 16912307] [evidence IMP]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays [goid 10212] [pmid 12773567] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level [goid 1666] [pmid 16915281] [evidence IDA]; Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication [goid 2230] [pmid 16873256] [evidence IMP]; Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication [goid 2230] [pmid 16873257] [evidence IMP]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; The aggregation, arrangement and bonding together of a set of components to form a protein complex [goid 6461] [pmid 12915590] [evidence IDA]; The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif [goid 6605] [pmid 11080164] [evidence IDA]; The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif [goid 6605] [pmid 15195100] [evidence IMP]; A process that directly activates any of the steps required for cell death by apoptosis [goid 6917] [pmid 11080164] [evidence IDA]; A process that directly activates any of the steps required for cell death by apoptosis [goid 6917] [pmid 9583681] [evidence IDA]; A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle [goid 6977] [evidence ISS]; The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) [goid 7050] [pmid 12773567] [evidence IDA]; The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) [goid 7050] [pmid 9583681] [evidence IDA]; A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death) [goid 8630] [pmid 12402044] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription [goid 16481] [pmid 9448006] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of angiogenesis [goid 16525] [pmid 16915281] [evidence IMP]; Any process that stops, prevents or reduces the frequency, rate or extent of cell growth [goid 30308] [pmid 9583681] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of cell growth [goid 30308] [pmid 7935403] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of cell growth [goid 30308] [pmid 9448006] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of cell growth [goid 30308] [pmid 9395203] [evidence IDA]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia) [goid 30578] [pmid 8643677] [evidence IDA]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia) [goid 30578] [pmid 10779416] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones [goid 31065] [pmid 11259576] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals [goid 32938] [pmid 16915281] [evidence IDA]; A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death) [goid 42771] [evidence ISS]; Any process by which an organism has an effect on an organism of a different species [goid 44419] [evidence IEA]; Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle [goid 45930] [pmid 9395203] [evidence IDA]; Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation [goid 50821] [pmid 12773567] [evidence IDA]; Any process by which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus [goid 51457] [pmid 17332504] [evidence IDA]