The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin [goid 1892] [evidence IEA]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell [goid 7165] [evidence IEA]; The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate [goid 30154] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of transcription [goid 45941] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter [goid 45944] [evidence IEA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level [goid 1666] [pmid 8756616] [evidence IDA]; Any process that activates or increases the rate or extent of endothelial cell proliferation [goid 1938] [pmid 8756616] [evidence IC ]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell [goid 7165] [evidence IEA]; Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor [goid 10575] [pmid 8756616] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity [goid 30949] [pmid 8756616] [evidence IC ]; The synthesis of messenger RNA (mRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II-specific promoter [goid 42789] [pmid 7539918] [evidence IC ]; Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes [goid 43193] [pmid 8089148] [evidence IDA]; Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals [goid 43619] [pmid 8089148] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation [goid 45648] [pmid 1448077] [evidence IC ]; Any process that activates or increases the frequency, rate or extent of glycolysis [goid 45821] [pmid 8089148] [evidence IC ]; Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones [goid 46886] [pmid 1448077] [evidence IDA]