The hydrolysis of a peptide bond or bonds within a protein [goid 6508] [evidence IEA]; The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord [goid 7417] [pmid 12589961] [evidence NAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism [goid 9611] [pmid 12016211] [evidence NAS]; Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein [goid 16540] [pmid 12878203] [evidence NAS]; The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells [goid 30574] [pmid 12878203] [evidence NAS]; The regrowth of lost or destroyed tissues [goid 42246] [pmid 12878203] [evidence NAS]; The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone [goid 42445] [pmid 11668196] [evidence NAS]; The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier [goid 42552] [pmid 11668196] [evidence NAS]; The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease [goid 42982] [pmid 12709365] [evidence NAS]; Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features [goid 45595] [pmid 11668196] [evidence NAS]; The hydrolysis of a peptide bond or bonds within a protein [goid 6508] [evidence IEA]