The modification of histones by addition of methyl groups [goid 16571] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of transcription [goid 45941] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter [goid 122] [pmid 9989505] [evidence IDA]; Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways [goid 165] [pmid 12226747] [evidence IDA]; Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein [goid 1933] [pmid 12226747] [evidence IDA]; The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone [goid 2076] [pmid 15563473] [evidence IGI]; The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway [goid 6281] [pmid 12874027] [evidence NAS]; Any process that stops, prevents or reduces the rate or extent of cell proliferation [goid 8285] [pmid 15331604] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers [goid 9411] [pmid 16690369] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum [goid 10332] [pmid 12874027] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription [goid 16481] [pmid 12226747] [evidence IDA]; The modification of histones by addition of methyl groups [goid 16571] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity [goid 30511] [pmid 11274402] [evidence IMP]; Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription [goid 43433] [pmid 12226747] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription [goid 43433] [pmid 11526476] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of osteoblast differentiation [goid 45668] [pmid 15563473] [evidence IGI]; Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity [goid 45736] [pmid 15640349] [evidence IMP]; Any process that activates or increases the frequency, rate or extent of transcription [goid 45941] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade [goid 46329] [pmid 12226747] [evidence IDA]; Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) [goid 51974] [pmid 12837246] [evidence IMP]