The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes [goid 1766] [pmid 12153479] [evidence TAS]; A process that directly activates any of the steps required for cell death by apoptosis [goid 6917] [pmid 10366425] [evidence NAS]; The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord [goid 7417] [pmid 10739088] [evidence TAS]; The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate [goid 30154] [pmid 10739088] [evidence TAS]; The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier [goid 42552] [pmid 12153479] [evidence NAS]; The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier [goid 42552] [pmid 10428054] [evidence TAS]; Any process by which a protein is transported to, or maintained in, apical regions of the cell [goid 45176] [pmid 10739088] [evidence TAS]