Any process that modulates the frequency, rate or extent of CDK activity [goid 79] [evidence IEA]; The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation [goid 1836] [pmid 11574543] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity [goid 6469] [pmid 8515476] [evidence TAS]; The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell [goid 7165] [pmid 8515476] [evidence TAS]; The multiplication or reproduction of cells, resulting in the expansion of a cell population [goid 8283] [pmid 10767298] [evidence TAS]; A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death) [goid 8630] [pmid 11574543] [evidence IDA]; The intracellular signaling cascade that results when a cell is triggered to undergo apoptosis [goid 8632] [pmid 11574543] [evidence IDA]; The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte [goid 30216] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of cell growth [goid 30307] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity [goid 43154] [pmid 11574543] [evidence IDA]; The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue [goid 43588] [evidence IEA]