The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK [goid 186] [pmid 10660600] [evidence IDA]; Any process that modulates the frequency, rate or extent of cell growth [goid 1558] [pmid 10660600] [evidence NAS]; The process of directing proteins towards a membrane using signals contained within the protein [goid 6612] [pmid 10660600] [evidence NAS]; A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface [goid 6915] [pmid 10660600] [evidence NAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation) [goid 6950] [pmid 10660600] [evidence IDA]; Any process that modulates the surface configuration of a cell [goid 8360] [pmid 10660600] [evidence IDA]; The orderly movement of cells from one site to another, often during the development of a multicellular organism [goid 16477] [pmid 10660600] [evidence NAS]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins [goid 30036] [pmid 10660600] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade [goid 46330] [pmid 10660600] [evidence IDA]; Establishment and maturation of focal adhesions, complexes of intracellular signaling and structural proteins which provide a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity [goid 48041] [pmid 10660600] [evidence IDA]; The process of introducing a phosphate group on to a protein [goid 6468] [evidence IEA]; The process of introducing a phosphate group on to a protein [goid 6468] [evidence IEA]