The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope [goid 60] [pmid 16280327] [evidence IMP]; The process whereby a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell [goid 2268] [evidence IEA]; The process whereby a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL) [goid 2315] [evidence IEA]; An immune response dependent upon secreted immunoglobulin [goid 2455] [evidence IEA]; The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation [goid 2467] [evidence IEA]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism [goid 6974] [pmid 16384933] [evidence IDA]; A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase [goid 7249] [pmid 8196632] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus [goid 9615] [pmid 16306601] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm [goid 10225] [pmid 16384933] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription [goid 16481] [pmid 16306601] [evidence IDA]; An immune response against microbes mediated through a body fluid [goid 19730] [evidence IEA]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an extracellular matrix [goid 30198] [evidence IEA]; Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon [goid 32729] [evidence IEA]; An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin [goid 42088] [evidence IEA]; Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane [goid 42345] [pmid 8196632] [evidence IEP]; Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis [goid 42536] [evidence IEA]; Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism [goid 42742] [evidence IEA]; A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death) [goid 42771] [pmid 16384933] [evidence IMP]; Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism [goid 42832] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis [goid 43066] [pmid 16384933] [evidence IDA]; The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell [goid 45064] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10 [goid 45082] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8 [goid 45415] [pmid 16306601] [evidence IMP]; Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA [goid 45727] [pmid 16384933] [evidence IMP]; Any process that activates or increases the frequency, rate or extent of transcription [goid 45941] [pmid 16384933] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter [goid 45944] [evidence IEA]; The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions [goid 48536] [evidence IEA]; Any process that modulates the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid [goid 51101] [pmid 9407099] [evidence IEP]; Any process by which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus [goid 51457] [pmid 8196632] [evidence NAS]