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+### TigerBx: Tissue Mask Generation for Brain Extration
+
+### Validation pipeline (after v0.1.16)
+
+    import tigerbx
+    import time
+    t = time.time()
+    # tigerbx.val(argstring, input_dir, output_dir=None, model=None, GPU=False, debug=False)
+    df, metric1 = tigerbx.val('bet_NFBS', 'NFBS_Dataset','temp', GPU=True)
+    df, metric2 = tigerbx.val('bet_synstrip', 'synthstrip_data_v1.4','temp', GPU=True)
+    df, metric3 = tigerbx.val('aseg_123', 'aseg', 'temp', GPU=True)
+    df, metric4 = tigerbx.val('dgm_123', 'aseg', 'temp', GPU=True)
+    df, metric5 = tigerbx.val('syn_123', 'aseg', 'temp', GPU=True)
+    df, metric6 = tigerbx.val('reg_60', 'aseg', 'temp', GPU=True, template='Template_T1_tbet.nii.gz')
+
+    
+    print('bet_NFBS', metric1)
+    print('bet_synstrip', metric2)
+    print('aseg_123', metric3)
+    print('dgm_123', metric4)
+    print('syn_123', metric5)
+    print('reg_60', metric6)
+    print('Time', time.time() - t)
+
+### Validation Datasets
+1. Skull Stripping: [NFBS_Dataset](http://preprocessed-connectomes-project.org/NFB_skullstripped)
+2. Skull Stripping: [Synstrip](https://surfer.nmr.mgh.harvard.edu/docs/synthstrip)
+3. Deep gray matter: [MindBoggle-101](https://mindboggle.info/)
+4. Deep gray matter: [CANDI](https://www.nitrc.org/projects/candi_share/)
+5. Registration: [ABIDE](https://fcon_1000.projects.nitrc.org/indi/abide/)
+
+
+### Internal Validation Sets:
+1. aseg: A combination of MindBoggle-101 and CANDI (N = 123) with DGM labels
+
+### Validation Results of Verion 0.1.16
+#### Deep Gray matter: Dice coefficients
+
+    | Structure  | L/R | aseg  | dgm  | syn  | L/R | aseg  | dgm  | syn  |
+    |------------|-----|-------|------|------|-----|-------|------|------|
+    | Thalamus   | L   | 0.879 | 0.898| 0.890| R   | 0.889 | 0.902| 0.884|
+    | Caudate    | L   | 0.875 | 0.874| 0.850| R   | 0.875 | 0.872| 0.845|
+    | Putamen    | L   | 0.873 | 0.885| 0.847| R   | 0.862 | 0.880| 0.829|
+    | Pallidum   | L   | 0.827 | 0.827| 0.828| R   | 0.814 | 0.815| 0.794|
+    | Hippocampus| L   | 0.808 | 0.828| 0.789| R   | 0.810 | 0.831| 0.779|
+    | Amygdala   | L   | 0.737 | 0.764| 0.716| R   | 0.727 | 0.750| 0.711|
+    | Mean       | L   | 0.833 | 0.846| 0.820| R   | 0.829 | 0.841| 0.807|
+#### Registration:
+    mean dice: 0.797
+    mean dice: 0.804(FuseMorph)
+
+#### Skull Stripping
+    bet_NFBS: 0.973
+    bet_synstrip: 0.971
+
+
+
+
+