--- a
+++ b/CMakeLists.txt
@@ -0,0 +1,82 @@
+cmake_minimum_required(VERSION 3.16.3...3.26)
+
+project(ants LANGUAGES CXX)
+
+# Set the macOS SDK root
+if (CMAKE_SYSTEM_NAME STREQUAL "Darwin")
+    execute_process(
+        COMMAND xcrun --show-sdk-path
+        OUTPUT_VARIABLE SDK_PATH
+        OUTPUT_STRIP_TRAILING_WHITESPACE
+    )
+    set(CMAKE_OSX_SYSROOT ${SDK_PATH})
+    message(STATUS "Using macOS SDK: ${CMAKE_OSX_SYSROOT}")
+endif()
+
+set(CMAKE_POSITION_INDEPENDENT_CODE ON)
+
+# Try to import all Python components potentially needed by nanobind
+find_package(Python 3.8
+  REQUIRED COMPONENTS Interpreter Development.Module)
+
+# Import nanobind through CMake's find_package mechanism
+find_package(nanobind CONFIG REQUIRED)
+
+# TODO: make this run only if ITK + ANTs are not already built
+if(CMAKE_SYSTEM_NAME STREQUAL "Windows")
+  execute_process(COMMAND cmd /c ${PROJECT_SOURCE_DIR}/scripts/configure_ITK.bat)
+  execute_process(COMMAND cmd /c ${PROJECT_SOURCE_DIR}/scripts/configure_ANTs.bat)
+else()
+  execute_process(COMMAND bash ${PROJECT_SOURCE_DIR}/scripts/configure_ITK.sh)
+  execute_process(COMMAND bash ${PROJECT_SOURCE_DIR}/scripts/configure_ANTs.sh)
+endif()
+
+# ITK
+set(ITK_DIR "./itkbuild")
+find_package(ITK REQUIRED)
+include(${ITK_USE_FILE})
+
+# ANTS
+add_library(antsUtilities STATIC src/antscore/antsUtilities.cxx src/antscore/antsCommandLineOption.cxx src/antscore/antsCommandLineParser.cxx src/antscore/ReadWriteData.cxx src/antscore/ANTsVersion.cxx)
+add_library(registrationUtilities STATIC  src/antscore/antsRegistrationTemplateHeader.cxx
+                                          src/antscore/antsRegistration2DDouble.cxx src/antscore/antsRegistration2DFloat.cxx
+                                          src/antscore/antsRegistration3DDouble.cxx src/antscore/antsRegistration3DFloat.cxx
+                                          src/antscore/antsRegistration4DDouble.cxx src/antscore/antsRegistration4DFloat.cxx)
+
+
+add_library(imageMathUtilities STATIC  src/antscore/ImageMathHelper2D.cxx src/antscore/ImageMathHelper3D.cxx src/antscore/ImageMathHelper4D.cxx)
+
+# this may not be needed
+target_link_libraries(antsUtilities ${ITK_LIBRARIES})
+target_link_libraries(registrationUtilities ${ITK_LIBRARIES})
+target_link_libraries(imageMathUtilities ${ITK_LIBRARIES})
+
+nanobind_add_module(
+  lib
+  NB_STATIC
+  src/main.cpp
+  src/antscore/antsAffineInitializer.cxx
+  src/antscore/antsApplyTransforms.cxx
+  src/antscore/antsApplyTransformsToPoints.cxx
+  src/antscore/antsJointFusion.cxx
+  src/antscore/antsRegistration.cxx
+  src/antscore/Atropos.cxx
+  src/antscore/AverageAffineTransform.cxx
+  src/antscore/AverageAffineTransformNoRigid.cxx
+  src/antscore/CreateJacobianDeterminantImage.cxx
+  src/antscore/DenoiseImage.cxx
+  src/antscore/iMath.cxx
+  src/antscore/KellyKapowski.cxx
+  src/antscore/LabelClustersUniquely.cxx
+  src/antscore/LabelGeometryMeasures.cxx
+  src/antscore/N3BiasFieldCorrection.cxx
+  src/antscore/N4BiasFieldCorrection.cxx
+  src/antscore/ResampleImage.cxx
+  src/antscore/ThresholdImage.cxx
+  src/antscore/TileImages.cxx
+)
+target_compile_options(lib PRIVATE -O3)
+target_link_libraries(lib PRIVATE ${ITK_LIBRARIES} antsUtilities registrationUtilities imageMathUtilities)
+
+# Install directive for scikit-build-core
+install(TARGETS lib LIBRARY DESTINATION ants)
\ No newline at end of file