"""

.. _tut-dics:

======================

DICS for power mapping

======================

In this tutorial, we'll simulate two signals originating from two

locations on the cortex. These signals will be sinusoids, so we'll be looking

at oscillatory activity (as opposed to evoked activity).

We'll use dynamic imaging of coherent sources (DICS) :footcite:`GrossEtAl2001`

to map out spectral power along the cortex. Let's see if we can find our two

simulated sources.

"""

# Author: Marijn van Vliet <w.m.vanvliet@gmail.com>

#

# License: BSD-3-Clause

# Copyright the MNE-Python contributors.

# %%

# Setup

# -----

# We first import the required packages to run this tutorial and define a list

# of filenames for various things we'll be using.

import numpy as np

from matplotlib import pyplot as plt

from scipy.signal import coherence, unit_impulse, welch

import mne

from mne.beamformer import apply_dics_csd, make_dics

from mne.datasets import sample

from mne.minimum_norm import apply_inverse, make_inverse_operator

from mne.simulation import add_noise, simulate_raw

from mne.time_frequency import csd_morlet

# We use the MEG and MRI setup from the MNE-sample dataset

data_path = sample.data_path(download=False)

subjects_dir = data_path / "subjects"

# Filenames for various files we'll be using

meg_path = data_path / "MEG" / "sample"

raw_fname = meg_path / "sample_audvis_raw.fif"

fwd_fname = meg_path / "sample_audvis-meg-eeg-oct-6-fwd.fif"

cov_fname = meg_path / "sample_audvis-cov.fif"

fwd = mne.read_forward_solution(fwd_fname)

# Seed for the random number generator

rand = np.random.RandomState(42)

# %%

# Data simulation

# ---------------

#

# The following function generates a timeseries that contains an oscillator,

# whose frequency fluctuates a little over time, but stays close to 10 Hz.

# We'll use this function to generate our two signals.

sfreq = 50.0  # Sampling frequency of the generated signal

n_samp = int(round(10.0 * sfreq))

times = np.arange(n_samp) / sfreq  # 10 seconds of signal

n_times = len(times)

def coh_signal_gen():

    """Generate an oscillating signal.

    Returns

    -------

    signal : ndarray

        The generated signal.

    """

    t_rand = 0.001  # Variation in the instantaneous frequency of the signal

    std = 0.1  # Std-dev of the random fluctuations added to the signal

    base_freq = 10.0  # Base frequency of the oscillators in Hertz

    n_times = len(times)

    # Generate an oscillator with varying frequency and phase lag.

    signal = np.sin(

        2.0

        * np.pi

        * (

            base_freq * np.arange(n_times) / sfreq

            + np.cumsum(t_rand * rand.randn(n_times))

        )

    )

    # Add some random fluctuations to the signal.

    signal += std * rand.randn(n_times)

    # Scale the signal to be in the right order of magnitude (~100 nAm)

    # for MEG data.

    signal *= 100e-9

    return signal

# %%

# Let's simulate two timeseries and plot some basic information about them.

signal1 = coh_signal_gen()

signal2 = coh_signal_gen()

fig, axes = plt.subplots(2, 2, figsize=(8, 4), layout="constrained")

# Plot the timeseries

ax = axes[0][0]

ax.plot(times, 1e9 * signal1, lw=0.5)

ax.set(

    xlabel="Time (s)", xlim=times[[0, -1]], ylabel="Amplitude (Am)", title="Signal 1"

)

ax = axes[0][1]

ax.plot(times, 1e9 * signal2, lw=0.5)

ax.set(xlabel="Time (s)", xlim=times[[0, -1]], title="Signal 2")

# Power spectrum of the first timeseries

f, p = welch(signal1, fs=sfreq, nperseg=128, nfft=256)

ax = axes[1][0]

# Only plot the first 100 frequencies

ax.plot(f[:100], 20 * np.log10(p[:100]), lw=1.0)

ax.set(

    xlabel="Frequency (Hz)",

    xlim=f[[0, 99]],

    ylabel="Power (dB)",

    title="Power spectrum of signal 1",

)

# Compute the coherence between the two timeseries

f, coh = coherence(signal1, signal2, fs=sfreq, nperseg=100, noverlap=64)

ax = axes[1][1]

ax.plot(f[:50], coh[:50], lw=1.0)

ax.set(

    xlabel="Frequency (Hz)",

    xlim=f[[0, 49]],

    ylabel="Coherence",

    title="Coherence between the timeseries",

)

# %%

# Now we put the signals at two locations on the cortex. We construct a

# :class:`mne.SourceEstimate` object to store them in.

#

# The timeseries will have a part where the signal is active and a part where

# it is not. The techniques we'll be using in this tutorial depend on being

# able to contrast data that contains the signal of interest versus data that

# does not (i.e. it contains only noise).

# The locations on the cortex where the signal will originate from. These

# locations are indicated as vertex numbers.

vertices = [[146374], [33830]]

# Construct SourceEstimates that describe the signals at the cortical level.

data = np.vstack((signal1, signal2))

stc_signal = mne.SourceEstimate(

    data, vertices, tmin=0, tstep=1.0 / sfreq, subject="sample"

)

stc_noise = stc_signal * 0.0

# %%

# Before we simulate the sensor-level data, let's define a signal-to-noise

# ratio. You are encouraged to play with this parameter and see the effect of

# noise on our results.

snr = 1.0  # Signal-to-noise ratio. Decrease to add more noise.

# %%

# Now we run the signal through the forward model to obtain simulated sensor

# data. To save computation time, we'll only simulate gradiometer data. You can

# try simulating other types of sensors as well.

#

# Some noise is added based on the baseline noise covariance matrix from the

# sample dataset, scaled to implement the desired SNR.

# Read the info from the sample dataset. This defines the location of the

# sensors and such.

info = mne.io.read_raw(raw_fname).crop(0, 1).resample(50).info

# Only use gradiometers

picks = mne.pick_types(info, meg="grad", stim=True, exclude=())

mne.pick_info(info, picks, copy=False)  # modifies info in-place

# Define a covariance matrix for the simulated noise. In this tutorial, we use

# a simple diagonal matrix.

cov = mne.cov.make_ad_hoc_cov(info)

cov["data"] *= (20.0 / snr) ** 2  # Scale the noise to achieve the desired SNR

# Simulate the raw data, with a lowpass filter on the noise

stcs = [

    (stc_signal, unit_impulse(n_samp, dtype=int) * 1),

    (stc_noise, unit_impulse(n_samp, dtype=int) * 2),

]  # stacked in time

duration = (len(stc_signal.times) * 2) / sfreq

raw = simulate_raw(info, stcs, forward=fwd)

add_noise(raw, cov, iir_filter=[4, -4, 0.8], random_state=rand)

# %%

# We create an :class:`mne.Epochs` object containing two trials: one with

# both noise and signal and one with just noise

events = mne.find_events(raw, initial_event=True)

tmax = (len(stc_signal.times) - 1) / sfreq

epochs = mne.Epochs(

    raw,

    events,

    event_id=dict(signal=1, noise=2),

    tmin=0,

    tmax=tmax,

    baseline=None,

    preload=True,

)

assert len(epochs) == 2  # ensure that we got the two expected events

# Plot some of the channels of the simulated data that are situated above one

# of our simulated sources.

picks = mne.read_vectorview_selection("Left-frontal")  # contains both mag and grad

picks = [p for p in picks if p in epochs.ch_names]  # now only grads

epochs.plot(picks=picks, events=True)

# %%

# Power mapping

# -------------

# With our simulated dataset ready, we can now pretend to be researchers that

# have just recorded this from a real subject and are going to study what parts

# of the brain communicate with each other.

#

# First, we'll create a source estimate of the MEG data. We'll use both a

# straightforward MNE-dSPM inverse solution for this, and the DICS beamformer

# which is specifically designed to work with oscillatory data.

# %%

# Computing the inverse using MNE-dSPM:

# Compute the inverse operator

fwd = mne.read_forward_solution(fwd_fname)

inv = make_inverse_operator(epochs.info, fwd, cov)

# Apply the inverse model to the trial that also contains the signal.

s = apply_inverse(epochs["signal"].average(), inv)

# Take the root-mean square along the time dimension and plot the result.

s_rms = np.sqrt((s**2).mean())

title = "MNE-dSPM inverse (RMS)"

brain = s_rms.plot(

    "sample",

    subjects_dir=subjects_dir,

    hemi="both",

    figure=1,

    size=600,

    time_label=title,

    title=title,

)

# Indicate the true locations of the source activity on the plot.

brain.add_foci(vertices[0][0], coords_as_verts=True, hemi="lh")

brain.add_foci(vertices[1][0], coords_as_verts=True, hemi="rh")

# Rotate the view and add a title.

brain.show_view(azimuth=0, elevation=0, distance=550, focalpoint=(0, 0, 0))

# %%

# We will now compute the cortical power map at 10 Hz. using a DICS beamformer.

# A beamformer will construct for each vertex a spatial filter that aims to

# pass activity originating from the vertex, while dampening activity from

# other sources as much as possible.

#

# The :func:`mne.beamformer.make_dics` function has many switches that offer

# precise control

# over the way the filter weights are computed. Currently, there is no clear

# consensus regarding the best approach. This is why we will demonstrate two

# approaches here:

#

#  1. The approach as described in :footcite:`vanVlietEtAl2018`, which first

#     normalizes the forward solution and computes a vector beamformer.

#  2. The scalar beamforming approach based on

#     :footcite:`SekiharaNagarajan2008`, which uses weight normalization

#     instead of normalizing the forward solution.

# Estimate the cross-spectral density (CSD) matrix on the trial containing the

# signal.

csd_signal = csd_morlet(epochs["signal"], frequencies=[10])

# Compute the spatial filters for each vertex, using two approaches.

filters_approach1 = make_dics(

    info,

    fwd,

    csd_signal,

    reg=0.05,

    pick_ori="max-power",

    depth=1.0,

    inversion="single",

    weight_norm=None,

    real_filter=True,

)

print(filters_approach1)

filters_approach2 = make_dics(

    info,

    fwd,

    csd_signal,

    reg=0.05,

    pick_ori="max-power",

    depth=None,

    inversion="matrix",

    weight_norm="unit-noise-gain",

    real_filter=True,

)

print(filters_approach2)

# You can save these to disk with:

# filters_approach1.save('filters_1-dics.h5')

# Compute the DICS power map by applying the spatial filters to the CSD matrix.

power_approach1, f = apply_dics_csd(csd_signal, filters_approach1)

power_approach2, f = apply_dics_csd(csd_signal, filters_approach2)

# %%

# Plot the DICS power maps for both approaches, starting with the first:

def plot_approach(power, n):

    """Plot the results on a brain."""

    title = f"DICS power map, approach {n}"

    brain = power_approach1.plot(

        "sample",

        subjects_dir=subjects_dir,

        hemi="both",

        size=600,

        time_label=title,

        title=title,

    )

    # Indicate the true locations of the source activity on the plot.

    brain.add_foci(vertices[0][0], coords_as_verts=True, hemi="lh", color="b")

    brain.add_foci(vertices[1][0], coords_as_verts=True, hemi="rh", color="b")

    # Rotate the view and add a title.

    brain.show_view(azimuth=0, elevation=0, distance=550, focalpoint=(0, 0, 0))

    return brain

brain1 = plot_approach(power_approach1, 1)

# %%

# Now the second:

brain2 = plot_approach(power_approach2, 2)

# %%

# Excellent! All methods found our two simulated sources. Of course, with a

# signal-to-noise ratio (SNR) of 1, is isn't very hard to find them. You can

# try playing with the SNR and see how the MNE-dSPM and DICS approaches hold up

# in the presence of increasing noise. In the presence of more noise, you may

# need to increase the regularization parameter of the DICS beamformer.

#

# References

# ----------

# .. footbibliography::