[aba580]: / third_party / nucleus / io / bed_reader.h

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/*
* Copyright 2018 Google LLC.
*
* Redistribution and use in source and binary forms, with or without
* modification, are permitted provided that the following conditions
* are met:
*
* 1. Redistributions of source code must retain the above copyright notice,
* this list of conditions and the following disclaimer.
*
* 2. Redistributions in binary form must reproduce the above copyright
* notice, this list of conditions and the following disclaimer in the
* documentation and/or other materials provided with the distribution.
*
* 3. Neither the name of the copyright holder nor the names of its
* contributors may be used to endorse or promote products derived from this
* software without specific prior written permission.
*
* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
* AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
* IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
* ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
* LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
* CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
* SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
* INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
* CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
* ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE
* POSSIBILITY OF SUCH DAMAGE.
*/
#ifndef THIRD_PARTY_NUCLEUS_IO_BED_READER_H_
#define THIRD_PARTY_NUCLEUS_IO_BED_READER_H_
#include <memory>
#include <string>
#include "htslib/hts.h"
#include "htslib/tbx.h"
#include "third_party/nucleus/io/reader_base.h"
#include "third_party/nucleus/io/text_reader.h"
#include "third_party/nucleus/platform/types.h"
#include "third_party/nucleus/protos/bed.pb.h"
#include "third_party/nucleus/core/statusor.h"
#include "third_party/nucleus/core/status.h"
#include "third_party/nucleus/protos/range.pb.h"
namespace nucleus {
using nucleus::genomics::v1::Range;
// Alias for the abstract base class for BED record iterables.
using BedIterable = Iterable<nucleus::genomics::v1::BedRecord>;
// A BED reader.
//
// BED files are flexible stores of information about a genome annotation track.
//
// https://genome.ucsc.edu/FAQ/FAQformat.html#format1
//
// This class provides a method to iterate through a BED file.
//
// The objects returned by iterate() are nucleus.genomics.v1.BedRecord
// objects parsed from the BED records in the file.
//
// Note: Only tab-delimited BED files are supported, for ease of future support
// for tabix-indexed BED file querying.
//
class BedReader : public Reader {
public:
// Creates a new BedReader reading reads from the BED file bed_path.
//
// bed_path must point to an existing BED formatted file.
//
// Returns a StatusOr that is OK if the BedReader could be successfully
// created or an error code indicating the error that occurred.
static StatusOr<std::unique_ptr<BedReader>> FromFile(
const string& bed_path,
const nucleus::genomics::v1::BedReaderOptions& options);
~BedReader();
// Disable copy and assignment operations.
BedReader(const BedReader& other) = delete;
BedReader& operator=(const BedReader&) = delete;
// Gets all of the BED records in this file in order.
//
// The specific parsing, filtering, etc behavior is determined by the options
// provided during construction. Returns an OK status if the iterable can be
// constructed, or not OK otherwise.
StatusOr<std::shared_ptr<BedIterable>> Iterate() const;
// Gets a subset of the BED records in this file.
//
// Operates similar to Iterate(), but allows for querying of specific regions.
// If range isn't a valid interval in this BED file a non-OK status value will
// be returned.
StatusOr<std::shared_ptr<BedIterable>> Query(const Range& region);
// Returns True if this BedReader loaded an index file.
bool HasIndex() const { return idx_ != nullptr; }
// Close the underlying resource descriptors. Returns a Status to indicate if
// everything went OK with the close.
::nucleus::Status Close();
// This no-op function is needed only for Python context manager support.
void PythonEnter() const {}
// Get the options controlling the behavior of this BedReader.
const nucleus::genomics::v1::BedReaderOptions& Options() const {
return options_;
}
// Returns the header that tracks the number of fields in each record in the
// reader.
const nucleus::genomics::v1::BedHeader& Header() const { return header_; }
// Returns OK if the input numTokens equals num_fields in the header.
::nucleus::Status Validate(const int numTokens) const;
private:
// Private constructor; use FromFile to safely create a BedReader from a
// file.
BedReader(std::unique_ptr<TextReader> text_reader,
const nucleus::genomics::v1::BedReaderOptions& options,
const nucleus::genomics::v1::BedHeader& header,
tbx_t* idx);
// Our options that control the behavior of this class.
const nucleus::genomics::v1::BedReaderOptions options_;
// The header that tracks the number of fields in each record in the file.
const nucleus::genomics::v1::BedHeader header_;
// A pointer to a raw TextReader object.
std::unique_ptr<TextReader> bed_reader_;
// A pointer to the htslib file used to access the Bedfile data.
htsFile* fp_;
// The htslib tbx_t data structure for tabix indexed files. May be NULL if no
// index was loaded.
tbx_t* idx_;
// Allow BedIterable objects to access fp_.
friend class BedFullFileIterable;
};
} // namespace nucleus
#endif // THIRD_PARTY_NUCLEUS_IO_BED_READER_H_