--- a +++ b/examples/chip-nexus/dataspec.yml @@ -0,0 +1,39 @@ +fasta_file: ../data/mm10.subset.fa # reference genome fasta file +task_specs: # specifies multiple tasks (e.g. Oct4, Sox2 Nanog) + + Oct4: + tracks: + - ../data/chip-nexus/Oct4/counts.pos.subset.bw + - ../data/chip-nexus/Oct4/counts.neg.subset.bw + peaks: ../data/chip-nexus/Oct4/idr-optimal-set.summit.subset.bed.gz + Sox2: + tracks: + - ../data/chip-nexus/Sox2/counts.pos.subset.bw + - ../data/chip-nexus/Sox2/counts.neg.subset.bw + peaks: ../data/chip-nexus/Sox2/idr-optimal-set.summit.subset.bed.gz + + Nanog: # Nanog is the task name + tracks: + # List of bigwig files (1 or more) corresponding to the task + # The model will predict each track individually (here coverage of + # reads mapping to the positive and negative strand) and + # the contribution scores will be averaged across all of these tracks + - ../data/chip-nexus/Nanog/counts.pos.subset.bw + - ../data/chip-nexus/Nanog/counts.neg.subset.bw + + # Peaks associated with Nanog task (optional) + # These are used to later run TF-MoDISco for Nanog contrib scores + # only in the Nanog peaks. + peaks: ../data/chip-nexus/Nanog/idr-optimal-set.summit.subset.bed.gz + +bias_specs: # specifies multiple bias tracks + input: # first bias track + tracks: # can specify multiple tracks + - ../data/chip-nexus/patchcap/counts.pos.subset.bw + - ../data/chip-nexus/patchcap/counts.neg.subset.bw + tasks: # applies to Oct4, Sox2, Nanog tasks + - Oct4 + - Sox2 + - Nanog + # NOTE: bias_specs don't specify peaks since they are only used + # to correct for biases