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        content="Comprehensive documentation for DNAnalyzer - Get started with our powerful DNA analysis tools and learn how to use all features.">
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                <h2>Documentation</h2>
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                    <h3>Getting Started</h3>
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                        <li><a href="#introduction" class="active">Introduction</a></li>
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                        <li><a href="#installation">Installation</a></li>
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                        <li><a href="#quick-start">Quick Start</a></li>
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                    <h3>Core Concepts</h3>
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                    <ul>
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                        <li><a href="#sequence-analysis">Sequence Analysis</a></li>
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                        <li><a href="#codon-detection">Codon Detection</a></li>
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                        <li><a href="#reading-frames">Reading Frames</a></li>
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                        <li><a href="#protein-prediction">Protein Prediction</a></li>
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                    <h3>Advanced Usage</h3>
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                        <li><a href="#server-setup">Server Setup</a></li>
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                    <h3>Resources</h3>
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                <h2>Documentation</h2>
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            <div class="docs-container">
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                <!-- Introduction -->
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                <section id="introduction" class="doc-section">
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                    <h1>Introduction to DNAnalyzer</h1>
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                    <p class="lead">DNAnalyzer is a powerful, privacy-focused DNA analysis tool using advanced machine
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                        learning models for accurate, on-device genomic analysis.</p>
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                    <p>This documentation will guide you through the installation, setup, and usage of DNAnalyzer for
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                        various DNA analysis tasks. Whether you're a researcher, educator, or bioinformatics enthusiast,
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                        you'll find comprehensive information on all of DNAnalyzer's capabilities.</p>
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                    <div class="info-box">
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                        <h3>Key Features</h3>
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                        <ul>
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                            <li><strong>Privacy-First Analysis:</strong> All processing occurs on your device, ensuring
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                                your genetic data never leaves your system.</li>
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                            <li><strong>Machine Learning Powered:</strong> Advanced ML algorithms provide exceptional
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                                accuracy in sequence analysis.</li>
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                            <li><strong>Comprehensive Tools:</strong> From basic sequence statistics to advanced protein
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                                prediction and promoter detection.</li>
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                            <li><strong>Open Source:</strong> DNAnalyzer is completely open source under the MIT
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                                License.</li>
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                        </ul>
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                    </div>
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                    <h2>System Requirements</h2>
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                    <p>Before getting started, ensure your system meets the following requirements:</p>
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                    <div class="code-block">
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                        <div class="code-header">
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                            <span class="code-label">System Requirements</span>
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                            <button class="copy-button">Copy</button>
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                        </div>
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                        <pre><code>- Operating System: Windows 10+, macOS 10.14+, or Linux (Ubuntu 18.04+)
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- Memory: 2GB RAM minimum (4GB+ recommended for large sequences)
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- Storage: 200MB for application, additional space for sequence files
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- Browser: Chrome 80+, Firefox 75+, Safari 13+, Edge 80+ (for web interface)
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- Java Runtime: Java 17+ (for server mode)</code></pre>
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                    </div>
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                </section>
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                <!-- Installation -->
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                <section id="installation" class="doc-section">
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                    <h1>Installation</h1>
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                    <p>DNAnalyzer can be installed and used in multiple ways depending on your needs and technical
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                        preferences.</p>
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                    <h2>Web Interface (No Installation)</h2>
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                    <p>The simplest way to use DNAnalyzer is through our web interface, which requires no installation:
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                    </p>
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                    <ol>
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                        <li>Visit <a href="../analyzer/analyzer.html">DNAnalyzer Web App</a></li>
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                        <li>Upload your DNA sequence files</li>
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                        <li>Select analysis options and get results</li>
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                    </ol>
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                    <p>The web interface runs entirely in your browser, ensuring your data never leaves your device.</p>
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                    <h2>Local Server Installation</h2>
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                    <p>For more advanced usage or batch processing, you can install DNAnalyzer as a local server:</p>
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                    <div class="tabs">
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                        <div class="tab-header">
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                            <button class="tab-button active" data-tab="windows">Windows</button>
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                            <button class="tab-button" data-tab="macos">macOS</button>
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                            <button class="tab-button" data-tab="linux">Linux</button>
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                        </div>
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                        <div class="tab-content active" id="windows">
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                            <ol>
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                                <li>Download the latest <a
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                                        href="https://github.com/VerisimilitudeX/DNAnalyzer/releases">DNAnalyzer
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                                        release</a> for Windows</li>
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                                <li>Extract the ZIP file to your preferred location</li>
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                                <li>Ensure Java 17 or newer is installed on your system</li>
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                                <li>Double-click on <code>dnanalyzer.bat</code> to start the server</li>
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                                <li>Access the interface at <code>http://localhost:8080</code> in your browser</li>
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                            </ol>
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                        </div>
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                        <div class="tab-content" id="macos">
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                            <ol>
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                                <li>Download the latest <a
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                                        href="https://github.com/VerisimilitudeX/DNAnalyzer/releases">DNAnalyzer
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                                        release</a> for macOS</li>
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                                <li>Extract the ZIP file to your preferred location</li>
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                                <li>Ensure Java 17 or newer is installed on your system</li>
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                                <li>Open Terminal and navigate to the extracted folder</li>
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                                <li>Run <code>chmod +x dnanalyzer.sh</code> to make the script executable</li>
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                                <li>Execute <code>./dnanalyzer.sh</code> to start the server</li>
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                                <li>Access the interface at <code>http://localhost:8080</code> in your browser</li>
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                            </ol>
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                        </div>
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                        <div class="tab-content" id="linux">
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                            <ol>
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                                <li>Download the latest <a
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                                        href="https://github.com/VerisimilitudeX/DNAnalyzer/releases">DNAnalyzer
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                                        release</a> for Linux</li>
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                                <li>Extract the archive to your preferred location</li>
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                                <li>Ensure Java 17 or newer is installed on your system</li>
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                                <li>Open Terminal and navigate to the extracted folder</li>
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                                <li>Run <code>chmod +x dnanalyzer.sh</code> to make the script executable</li>
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                                <li>Execute <code>./dnanalyzer.sh</code> to start the server</li>
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                                <li>Access the interface at <code>http://localhost:8080</code> in your browser</li>
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                            </ol>
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                        </div>
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                    </div>
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                    <h2>Building from Source</h2>
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                    <p>For developers or those who want the latest features, you can build DNAnalyzer from source:</p>
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                    <div class="code-block">
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                        <div class="code-header">
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                            <span class="code-label">Building from Source</span>
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                            <button class="copy-button">Copy</button>
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                        </div>
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                        <pre><code># Clone the repository
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git clone https://github.com/VerisimilitudeX/DNAnalyzer.git
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cd DNAnalyzer
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# Make the Gradle wrapper executable
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chmod +x ./gradlew
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# Build the project
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./gradlew clean bootJar
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# Run the server
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java -jar build/libs/DNAnalyzer.jar</code></pre>
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                    </div>
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                </section>
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                <!-- Quick Start -->
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                <section id="quick-start" class="doc-section">
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                    <h1>Quick Start Guide</h1>
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                    <p>This guide will help you quickly get started with DNAnalyzer's basic features.</p>
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                    <h2>Analyzing Your First DNA Sequence</h2>
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                    <p>Follow these steps to perform your first DNA sequence analysis:</p>
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                    <div class="steps">
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                        <div class="step">
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                            <div class="step-number">1</div>
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                            <div class="step-content">
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                                <h3>Upload a Sequence</h3>
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                                <p>Navigate to the <a href="../analyzer/analyzer.html">DNA Analyzer</a> page and upload
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                                    your FASTA or FASTQ file by dragging it to the upload area or clicking to browse.
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                                </p>
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                                <p><strong>Don't have a sequence file?</strong> Click "Import Sample" to use a
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                                    pre-loaded sample sequence.</p>
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                            </div>
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                        </div>
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                        <div class="step">
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                            <div class="step-number">2</div>
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                            <div class="step-content">
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                                <h3>Select Analysis Options</h3>
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                                <p>Choose which analysis features you want to run:</p>
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                                <ul>
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                                    <li><strong>Basic Analysis:</strong> Sequence length, GC content, base composition
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                                    </li>
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                                    <li><strong>Codon Analysis:</strong> Start codons, stop codons, reading frames</li>
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                                    <li><strong>Advanced Features:</strong> Coverage analysis, protein prediction,
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                                        promoter detection</li>
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                                </ul>
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                            </div>
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                        </div>
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                        <div class="step">
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                            <div class="step-number">3</div>
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                            <div class="step-content">
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                                <h3>Run Analysis</h3>
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                                <p>Click the "Start Analysis" button to process your sequence. The analysis time depends
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                                    on the sequence length and selected options.</p>
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                            </div>
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                        </div>
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                        <div class="step">
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                            <div class="step-number">4</div>
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                            <div class="step-content">
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                                <h3>Review Results</h3>
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                                <p>Examine the analysis results, which include visualizations, statistics, and detailed
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                                    information about your sequence.</p>
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                                <p>You can export the results in JSON, CSV, or text format for further processing or
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                                    documentation.</p>
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                            </div>
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                        </div>
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                    </div>
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                    <div class="info-box tip">
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                        <h3>Pro Tip</h3>
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                        <p>For large sequences (>1MB), consider using the local server installation for better
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                            performance and additional analysis options.</p>
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                    </div>
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                </section>
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                <!-- Sequence Analysis -->
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                <section id="sequence-analysis" class="doc-section">
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                    <h1>Sequence Analysis</h1>
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                    <p>DNAnalyzer provides comprehensive tools to analyze the basic properties of DNA sequences.</p>
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                    <h2>Base Composition Analysis</h2>
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                    <p>One of the fundamental analyses is determining the nucleotide composition of your DNA sequence:
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                    </p>
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                    <ul>
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                        <li><strong>Nucleotide Counts:</strong> Total count of A, T, G, C, and any other bases (N) in
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                            the sequence</li>
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                        <li><strong>Percentage Distribution:</strong> Proportion of each nucleotide type</li>
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                        <li><strong>Visualization:</strong> Interactive bar chart showing the distribution</li>
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                    </ul>
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                    <h2>GC Content Analysis</h2>
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                    <p>GC content is the percentage of nitrogenous bases in a DNA molecule that are either guanine (G)
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                        or cytosine (C):</p>
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                    <div class="code-block">
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                        <div class="code-header">
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                            <span class="code-label">GC Content Formula</span>
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                            <button class="copy-button">Copy</button>
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                        </div>
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                        <pre><code>GC Content (%) = (G + C) / (A + T + G + C) × 100</code></pre>
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                    </div>
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                    <p>GC content is important because:</p>
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                    <ul>
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                        <li>It affects DNA stability (higher GC content = more stable)</li>
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                        <li>GC-rich regions often indicate regulatory elements and gene-dense areas</li>
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                        <li>Different organisms have characteristic GC content ranges</li>
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                    </ul>
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                    <div class="info-box">
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                        <h3>Interpreting GC Content</h3>
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                        <ul>
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                            <li><strong>Low GC (< 40%):</strong> Common in AT-rich genomes like certain bacteria</li>
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                            <li><strong>Medium GC (40-60%):</strong> Typical of many eukaryotic genomes, including
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                                humans</li>
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                            <li><strong>High GC (> 60%):</strong> Often found in gene-rich regions and certain
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                                prokaryotes</li>
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                        </ul>
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                    </div>
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                </section>
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                <!-- More sections would continue here... -->
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                <!-- API Reference -->
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                <section id="api-reference" class="doc-section">
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                    <h1>API Reference</h1>
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                    <p>DNAnalyzer provides a RESTful API when running in server mode, allowing programmatic access to
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                        all analysis features.</p>
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                    <h2>API Endpoints</h2>
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                    <p>The following endpoints are available when the server is running:</p>
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                    <div class="api-endpoint">
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                        <div class="endpoint-method get">GET</div>
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                        <div class="endpoint-path">/api/v1/status</div>
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                        <div class="endpoint-description">
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                            <p>Check server status and version information</p>
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                            <h4>Response</h4>
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                            <div class="code-block">
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                                <pre><code>{
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  "status": "running",
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  "version": "1.0.0",
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  "uptime": "12h 34m 56s"
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}</code></pre>
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                            </div>
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                        </div>
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                    </div>
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                    <div class="api-endpoint">
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                        <div class="endpoint-method post">POST</div>
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                        <div class="endpoint-path">/api/v1/analyze</div>
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                        <div class="endpoint-description">
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                            <p>Analyze a DNA sequence file</p>
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                            <h4>Request</h4>
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                            <p>Form data with the following parameters:</p>
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                            <ul>
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                                <li><code>dnaFile</code> (required): The DNA sequence file to analyze</li>
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                                <li><code>options</code>: JSON string with analysis options</li>
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                            </ul>
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                            <h4>Response</h4>
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                            <div class="code-block">
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                                <pre><code>{
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  "sequence": {
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    "length": 1234,
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    "filename": "example.fa"
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  },
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  "basePairs": {
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    "counts": { "A": 300, "T": 310, "G": 320, "C": 304 },
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    "percentages": { "A": 24.3, "T": 25.1, "G": 25.9, "C": 24.7 },
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    "gcContent": 50.6
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  },
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  "analysis": {
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    // Additional analysis results based on options
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  }
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}</code></pre>
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                            </div>
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                        </div>
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                    </div>
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                    <div class="api-endpoint">
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                        <div class="endpoint-method post">POST</div>
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                        <div class="endpoint-path">/api/v1/base-pairs</div>
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                        <div class="endpoint-description">
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                            <p>Analyze base pair composition of a DNA sequence</p>
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                            <h4>Request</h4>
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                            <div class="code-block">
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                                <pre><code>{
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  "sequence": "ATGCATGCATGC"
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}</code></pre>
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                            </div>
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                            <h4>Response</h4>
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                            <div class="code-block">
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                                <pre><code>{
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  "counts": { "A": 3, "T": 3, "G": 3, "C": 3 },
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  "percentages": { "A": 25, "T": 25, "G": 25, "C": 25 },
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  "gcContent": 50
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}</code></pre>
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                            </div>
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                        </div>
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                    </div>
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                    <h2>Python Client Example</h2>
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                    <p>Here's a simple Python example to interact with the DNAnalyzer API:</p>
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                    <div class="code-block">
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                        <div class="code-header">
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                            <span class="code-label">Python</span>
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                            <button class="copy-button">Copy</button>
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                        </div>
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                        <pre><code>import requests
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# API base URL
477
BASE_URL = "http://localhost:8080/api/v1"
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# Check server status
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response = requests.get(f"{BASE_URL}/status")
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print("Server status:", response.json())
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# Analyze a sequence
484
with open("sequence.fa", "rb") as f:
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    files = {"dnaFile": f}
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    options = {
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        "sequence-length": True,
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        "gc-content": True,
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        "base-composition": True,
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        "start-codons": True,
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        "stop-codons": True
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    }
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    data = {"options": json.dumps(options)}
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    response = requests.post(f"{BASE_URL}/analyze", files=files, data=data)
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    # Print results
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    result = response.json()
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    print(f"Sequence length: {result['sequence']['length']}")
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    print(f"GC content: {result['basePairs']['gcContent']}%")</code></pre>
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                    </div>
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                </section>
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                <!-- FAQ Section -->
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                <section id="faq" class="doc-section">
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                    <h1>Frequently Asked Questions</h1>
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                    <div class="faq-item">
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                        <div class="faq-question">
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                            <h3>Is my DNA data secure when using DNAnalyzer?</h3>
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                            <i class="fas fa-chevron-down"></i>
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                        </div>
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                        <div class="faq-answer">
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                            <p>Yes, DNAnalyzer is designed with privacy as a fundamental principle. All processing
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                                occurs locally on your device, and your DNA sequence data never leaves your system. In
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                                web mode, analysis runs directly in your browser, and in server mode, it runs only on
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                                your local machine. We don't collect, store, or transmit any of your sequence data.</p>
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                        </div>
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                    </div>
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                    <div class="faq-item">
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                        <div class="faq-question">
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                            <h3>What file formats does DNAnalyzer support?</h3>
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                            <i class="fas fa-chevron-down"></i>
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                        </div>
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                        <div class="faq-answer">
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                            <p>DNAnalyzer supports the following file formats:</p>
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                            <ul>
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                                <li>FASTA (.fa, .fasta)</li>
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                                <li>FASTQ (.fastq)</li>
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                                <li>Plain text (.txt) containing DNA sequences</li>
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                            </ul>
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                            <p>The sequences should contain only A, T, G, C, and N (unknown) nucleotides. Other
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                                characters will be treated as unknown bases.</p>
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                        </div>
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                    </div>
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                    <div class="faq-item">
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                        <div class="faq-question">
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                            <h3>How large of a sequence can DNAnalyzer handle?</h3>
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                            <i class="fas fa-chevron-down"></i>
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                        </div>
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                        <div class="faq-answer">
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                            <p>The size limitations depend on the mode of operation:</p>
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                            <ul>
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                                <li><strong>Web Interface:</strong> Up to around 5MB sequence files, depending on your
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                                    browser and device memory</li>
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                                <li><strong>Local Server:</strong> Can handle much larger sequences, typically up to
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                                    several hundred MB</li>
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                            </ul>
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                            <p>For very large genomes (e.g., human genome), we recommend using the local server
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                                installation with a machine that has at least 8GB of RAM.</p>
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                        </div>
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                    </div>
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                    <div class="faq-item">
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                        <div class="faq-question">
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                            <h3>Can DNAnalyzer analyze my 23andMe or Ancestry DNA data?</h3>
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                            <i class="fas fa-chevron-down"></i>
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                        </div>
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                        <div class="faq-answer">
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                            <p>Not directly in the current version. DNAnalyzer is designed to work with full DNA
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                                sequences rather than SNP genotype data from consumer genetics services. However, we're
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                                developing a feature to support genotype data analysis in an upcoming version.</p>
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                            <p>If you have raw data from these services, you would need to convert it to a suitable
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                                format before using it with DNAnalyzer.</p>
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                        </div>
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                    </div>
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                            <p>Yes, DNAnalyzer is completely open source under the MIT License. You can view, modify,
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                                and contribute to the code on our <a
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                                    href="https://github.com/VerisimilitudeX/DNAnalyzer">GitHub repository</a>.</p>
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                    <p>To get started with contributing, please read our <a
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                            href="https://github.com/VerisimilitudeX/DNAnalyzer/blob/main/CONTRIBUTING.md">contribution
629
                            guidelines</a>.</p>
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