All annotations courtesy of the National Library of Medicine

Author's note: DNAse hypersensitive loci and most enhancer sequences are not included because, at the current state of DNAnalyzer, will not be of importance.

Coding Sequence (mutations along these sequences are very likely to affect the protein structure in a negative manner): atgcagaggt cgcctctgga aaaggccagc gttgtctcca aacttttttt cagctggacc

        agaccaattt tgaggaaagg atacagacag cgcctggaat tgtcagacat ataccaaatc

       ccttctgttg attctgctga caatctatct gaaaaattgg aaagagaatg ggatagagag

       ctggcttcaa agaaaaatcc taaactcatt aatgcccttc ggcgatgttt tttctggaga

       tttatgttct atggaatctt tttatattta ggggaagtca ccaaagcagt acagcctctc

       ttactgggaa gaatcatagc ttcctatgac ccggataaca aggaggaacg ctctatcgcg

       atttatctag gcataggctt atgccttctc tttattgtga ggacactgct cctacaccca

       gccatttttg gccttcatca cattggaatg cagatgagaa tagctatgtt tagtttgatt

       tataagaaga ctttaaagct gtcaagccgt gttctagata aaataagtat tggacaactt

       gttagtctcc tttccaacaa cctgaacaaa tttgatgaag gacttgcatt ggcacatttc

       gtgtggatcg ctcctttgca agtggcactc ctcatggggc taatctggga gttgttacag

       gcgtctgcct tctgtggact tggtttcctg atagtccttg ccctttttca ggctgggcta

       gggagaatga tgatgaagta cagagatcag agagctggga agatcagtga aagacttgtg

       attacctcag aaatgattga aaatatccaa tctgttaagg catactgctg ggaagaagca

       atggaaaaaa tgattgaaaa cttaagacaa acagaactga aactgactcg gaaggcagcc

       tatgtgagat acttcaatag ctcagccttc ttcttctcag ggttctttgt ggtgttttta

       tctgtgcttc cctatgcact aatcaaagga atcatcctcc ggaaaatatt caccaccatc

      tcattctgca ttgttctgcg catggcggtc actcggcaat ttccctgggc tgtacaaaca

      tggtatgact ctcttggagc aataaacaaa atacaggatt tcttacaaaa gcaagaatat

      aagacattgg aatataactt aacgactaca gaagtagtga tggagaatgt aacagccttc

      tgggaggagg gatttgggga attatttgag aaagcaaaac aaaacaataa caatagaaaa

      acttctaatg gtgatgacag cctcttcttc agtaatttct cacttcttgg tactcctgtc

      ctgaaagata ttaatttcaa gatagaaaga ggacagttgt tggcggttgc tggatccact

      ggagcaggca agacttcact tctaatggtg attatgggag aactggagcc ttcagagggt

      aaaattaagc acagtggaag aatttcattc tgttctcagt tttcctggat tatgcctggc

      accattaaag aaaatatcat ctttggtgtt tcctatgatg aatatagata cagaagcgtc

      atcaaagcat gccaactaga agaggacatc tccaagtttg cagagaaaga caatatagtt

      cttggagaag gtggaatcac actgagtgga ggtcaacgag caagaatttc tttagcaaga

      gcagtataca aagatgctga tttgtattta ttagactctc cttttggata cctagatgtt

      ttaacagaaa aagaaatatt tgaaagctgt gtctgtaaac tgatggctaa caaaactagg

      attttggtca cttctaaaat ggaacattta aagaaagctg acaaaatatt aattttgcat

      gaaggtagca gctattttta tgggacattt tcagaactcc aaaatctaca gccagacttt

      agctcaaaac tcatgggatg tgattctttc gaccaattta gtgcagaaag aagaaattca

      atcctaactg agaccttaca ccgtttctca ttagaaggag atgctcctgt ctcctggaca

      gaaacaaaaa aacaatcttt taaacagact ggagagtttg gggaaaaaag gaagaattct

      attctcaatc caatcaactc tatacgaaaa ttttccattg tgcaaaagac tcccttacaa

      atgaatggca tcgaagagga ttctgatgag cctttagaga gaaggctgtc cttagtacca

      gattctgagc agggagaggc gatactgcct cgcatcagcg tgatcagcac tggccccacg

      cttcaggcac gaaggaggca gtctgtcctg aacctgatga cacactcagt taaccaaggt

      cagaacattc accgaaagac aacagcatcc acacgaaaag tgtcactggc ccctcaggca

      aacttgactg aactggatat atattcaaga aggttatctc aagaaactgg cttggaaata

      agtgaagaaa ttaacgaaga agacttaaag gagtgctttt ttgatgatat ggagagcata

      ccagcagtga ctacatggaa cacatacctt cgatatatta ctgtccacaa gagcttaatt

      tttgtgctaa tttggtgctt agtaattttt ctggcagagg tggctgcttc tttggttgtg

      ctgtggctcc ttggaaacac tcctcttcaa gacaaaggga atagtactca tagtagaaat

      aacagctatg cagtgattat caccagcacc agttcgtatt atgtgtttta catttacgtg

      ggagtagccg acactttgct tgctatggga ttcttcagag gtctaccact ggtgcatact

      ctaatcacag tgtcgaaaat tttacaccac aaaatgttac attctgttct tcaagcacct

      atgtcaaccc tcaacacgtt gaaagcaggt gggattctta atagattctc caaagatata

      gcaattttgg atgaccttct gcctcttacc atatttgact tcatccagtt gttattaatt

      gtgattggag ctatagcagt tgtcgcagtt ttacaaccct acatctttgt tgcaacagtg

      ccagtgatag tggcttttat tatgttgaga gcatatttcc tccaaacctc acagcaactc

      aaacaactgg aatctgaagg caggagtcca attttcactc atcttgttac aagcttaaaa

      ggactatgga cacttcgtgc cttcggacgg cagccttact ttgaaactct gttccacaaa

      gctctgaatt tacatactgc caactggttc ttgtacctgt caacactgcg ctggttccaa

      atgagaatag aaatgatttt tgtcatcttc ttcattgctg ttaccttcat ttccatttta

      acaacaggag aaggagaagg aagagttggt attatcctga ctttagccat gaatatcatg

      agtacattgc agtgggctgt aaactccagc atagatgtgg atagcttgat gcgatctgtg

      agccgagtct ttaagttcat tgacatgcca acagaaggta aacctaccaa gtcaaccaaa

      ccatacaaga atggccaact ctcgaaagtt atgattattg agaattcaca cgtgaagaaa

      gatgacatct ggccctcagg gggccaaatg actgtcaaag atctcacagc aaaatacaca

      gaaggtggaa atgccatatt agagaacatt tccttctcaa taagtcctgg ccagagggtg

      ggcctcttgg gaagaactgg atcagggaag agtactttgt tatcagcttt tttgagacta

      ctgaacactg aaggagaaat ccagatcgat ggtgtgtctt gggattcaat aactttgcaa

      cagtggagga aagcctttgg agtgatacca cagaaagtat ttattttttc tggaacattt

      agaaaaaact tggatcccta tgaacagtgg agtgatcaag aaatatggaa agttgcagat

      gaggttgggc tcagatctgt gatagaacag tttcctggga agcttgactt tgtccttgtg

      gatgggggct gtgtcctaag ccatggccac aagcagttga tgtgcttggc tagatctgtt

      ctcagtaagg cgaagatctt gctgcttgat gaacccagtg ctcatttgga tccagtaaca

      taccaaataa ttagaagaac tctaaaacaa gcatttgctg attgcacagt aattctctgt

      gaacacagga tagaagcaat gctggaatgc caacaatttt tggtcataga agagaacaaa

      gtgcggcagt acgattccat ccagaaactg ctgaacgaga ggagcctctt ccggcaagcc

      atcagcccct ccgacagggt gaagctcttt ccccaccgga actcaagcaa gtgcaagtct

      aagccccaga ttgctgctct gaaagaggag acagaagaag aggtgcaaga tacaaggctt

      tag

This should translate to: 

             MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVD

                     SADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLL

                     GRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLI

                     YKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWEL

                     LQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC

                     WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR

                     KIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEV

                     VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIER

                     GQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIF

                     GVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDA

                     DLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSS

                     YFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTET

                     KKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVP

                     DSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAP

                     QANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVH

                     KSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYY

                     VFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGI

                     LNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLR

                     AYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN

                     WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWA

                     VNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIW

                     PSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN

                     TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD

                     EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP

                     VTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSL

                     FRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL

The most common cystic fibrosis mutation is ENIIFGVSYDE -> ENIIGVSYDE

CFTR Promoters: 

    Basal Promoter (attracts the formation of a transcription complex, located within the entire promoter region): gtagtaggtc tttggcatta ggagcttgag cccaga

    Promoter (whole sequence): gtagtaggtc tttggcatta ggagcttgag cccagacggc cctagcaggg accccagcgc ccgagagacc