--- a +++ b/docs/get_mindmap.md @@ -0,0 +1,71 @@ +# GET (Gene Expression Transformer) Implementation Mindmap + +## Implementation Status Overview +- [x] Basic Setup Complete (Repository & Structure) +- [ ] Data Pipeline Ready +- [ ] Model Running +- [ ] Results Validation + +## Data Pipeline +- Input Processing + - [ ] Gene expression data preprocessing + - [ ] Normalization techniques + - [ ] Feature selection + - [ ] Batch effect correction + +## Model Architecture +- Transformer-based + - [x] Self-attention layers (code available) + - [x] Feed-forward networks (code available) + - [x] Layer normalization (code available) +- Gene Expression Specific + - [x] Gene-gene interaction modeling (code available) + - [x] Pathway integration (code available) + - [x] Expression pattern recognition (code available) + +## Training Pipeline +- Data splitting + - [ ] Training set preparation + - [ ] Validation set preparation + - [ ] Test set preparation +- Loss functions + - [x] Expression prediction loss (code available) + - [x] Regulatory network loss (code available) +- Optimization + - [x] Learning rate scheduling (code available) + - [x] Gradient clipping (code available) + - [x] Early stopping (code available) + +## Inference Pipeline +- [ ] Batch processing +- [ ] Expression prediction +- [ ] Feature importance analysis +- [ ] Uncertainty quantification + +## Data Requirements +- Gene Expression Data + - [ ] PBMC data processed + - [ ] Peak sorting verified (chr1,chr2,chr3 order) + - [ ] Count matrix prepared + - [ ] Depth check (>3M recommended) +- Reference Data + - [ ] Gene annotation data + - [ ] Pathway databases + - [ ] Regulatory network information + +## Output Processing +- Analysis Tools + - [ ] Expression profile analysis + - [ ] Differential expression + - [ ] Pathway enrichment +- Visualization + - [ ] Expression heatmaps + - [ ] Network visualization + - [ ] PCA/t-SNE plots + +## Model Evaluation +- Performance Metrics + - [ ] MSE/MAE for expression prediction + - [ ] ROC/PR curves for classification +- [ ] Cross-validation +- [ ] Benchmarking against baselines