--- a
+++ b/docs/source/tissues.rst
@@ -0,0 +1,89 @@
+.. _tissues:
+
+Tissues (dosma.tissues)
+================================================================================
+This page details the different tissues that are supported by DOSMA and briefly
+explains the methods used for analysis and visualization.
+
+Tissues are loosely defined as structures of interest in anatomical regions.
+For example, both the femur and femoral cartilage are considered tissues are tissues
+of the knee.
+
+DOSMA currently supports 4 tissues:
+
+1. Femoral cartilage (fc)
+2. Tibial cartilage (tc)
+3. Patellar cartilage (pc)
+4. Meniscus (men)
+
+Different tissues have different quantitative profiles, visualization methods, and
+analysis techniques. The modules for the supported tissues implement and use these
+differences for analysis of each tissue.
+
+.. automodule::
+   dosma.tissues
+
+.. autosummary::
+   :toctree: generated
+   :nosignatures:
+
+   dosma.tissues.FemoralCartilage
+   dosma.tissues.TibialCartilage
+   dosma.tissues.PatellarCartilage
+   dosma.tissues.Meniscus
+
+Femoral Cartilage
+---------------------------------------------------------------------------------
+Femoral cartilage has been closely studied for evaluating knee health. The structure
+is often divided into sub-regions to evaluate the sensitivity of different regions of
+the knee to chronic diseases such as osteoarthritis. These regions are identified by
+three planes (12 regions):
+
+1. **Sagittal**: Medial, Lateral
+2. **Coronal**: Anterior, Central, Posterior
+3. **Depth**: Deep, Superficial
+
+For example, the deep-anterior-medial femoral cartilage tissue is one region.
+To analyze differences in these regions, |T2| maps can be unrolled onto a 2D plane :cite:`monu2017cluster`.
+
+DOSMA supports automatic division of femoral cartilage into these regions and unrolling of these regions.
+Unrolled maps are produced for deep, superficial, and total (combined deep and superficial) layers as seen below.
+
+.. figure:: figures/unrolled_fc.png
+   :align: center
+   :alt: Unrolled femoral cartilage |T2| maps
+   :figclass: align-center
+
+
+Tibial Cartilage
+--------------------------------------------------------------------------------
+Tibial cartilage is a flatter surface and is often divided across the three common
+planes:
+
+1. **Sagittal**: Medial, Lateral
+2. **Coronal**: Anterior, Central, Posterior
+3. **Axial**: Deep, Superficial
+
+DOSMA automatically divides the tissue into these regions and produces corresponding
+visualizations.
+
+
+Patellar Cartilage
+--------------------------------------------------------------------------------
+Patellar cartilage is a thin, flat tissue. Because of this structure, it is not often
+divided. However, there has been work that may suggest that deep/superficial differences
+in the patellar cartilage may be insightful.
+
+DOSMA divides patellar cartilage into deep/superficial layers across the coronal plane.
+
+
+Meniscus
+--------------------------------------------------------------------------------
+DOSMA supports quantitative processing and segmentation of the mensiscus.
+However, visualization for the meniscus is not yet supported.
+
+.. Substitutions
+.. |T2| replace:: T\ :sub:`2`
+.. |T1| replace:: T\ :sub:`1`
+.. |T1rho| replace:: T\ :sub:`1`:math:`{\rho}`
+.. |T2star| replace:: T\ :sub:`2`:sup:`*`