--- a +++ b/man/rnaseq_ic.Rd @@ -0,0 +1,27 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/rnaseq.R +\name{rnaseq_ic} +\alias{rnaseq_ic} +\title{Utility for using voom transformation with TMLE for biomarker discovery} +\usage{ +rnaseq_ic(biotmle, weights = TRUE, ...) +} +\arguments{ +\item{biotmle}{A \code{bioTMLE} object containing next-generation sequencing +count data in its "assays" slot.} + +\item{weights}{A \code{logical} indicating whether to return quality weights +of samples in the output object.} + +\item{...}{Other arguments to be passed to \code{\link[limma]{voom}} or +\code{\link[limma]{voomWithQualityWeights}} as appropriate.} +} +\value{ +\code{EList} object containing voom-transformed expression measures + of count data (actually, the mean-variance trend) in the "E" slot, to be + passed into the biomarker TMLE procedure. +} +\description{ +This function prepares next-generation sequencing data (counts) for use with +the biomarker TMLE procedure by invoking the voom transform of \code{limma}. +}