--- a +++ b/man/exp_biomarkertmle.Rd @@ -0,0 +1,42 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/biotmle.R +\name{exp_biomarkertmle} +\alias{exp_biomarkertmle} +\title{TMLE procedure using ATE for Biomarker Identication from Exposure} +\usage{ +exp_biomarkertmle(Y, A, W, g_lib, Q_lib, cv_folds, ...) +} +\arguments{ +\item{Y}{A \code{numeric} vector of expression values for a given biomarker.} + +\item{A}{A \code{numeric} vector of discretized exposure vector (e.g., from +a design matrix whose effect on expression values is of interest.} + +\item{W}{A \code{Matrix} of \code{numeric} values corresponding to baseline +covariates to be marginalized over in the estimation process.} + +\item{g_lib}{A \code{character} vector identifying the library of learning +algorithms to be used in fitting the propensity score P[A = a | W].} + +\item{Q_lib}{A \code{character} vector identifying the library of learning +algorithms to be used in fitting the outcome regression E[Y | A, W].} + +\item{cv_folds}{A \code{numeric} scalar indicating how many folds to use in +performing targeted minimum loss estimation. Cross-validated estimates are +more robust, allowing relaxing of theoretical conditions and construction +of conservative variance estimates.} + +\item{...}{Additional arguments passed to \code{\link[drtmle]{drtmle}} in +computing the targeted minimum loss estimator of the average treatment +effect.} +} +\value{ +TMLE-based estimate of the relationship between biomarker expression + and changes in an exposure variable, computed iteratively and saved in the + \code{tmleOut} slot in a \code{biotmle} object. +} +\description{ +This function performs influence curve-based estimation of the effect of an +exposure on biological expression values associated with a given biomarker, +controlling for a user-specified set of baseline covariates. +}