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biotmle 1.18.0 (BioC 3.14):
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- Forthcoming.
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---
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biotmle 1.17.0:
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- Removal of `future` and `doFuture` for simplification of parallelization. All
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  control of parallel computation now done through `BiocParallel`.
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---
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biotmle 1.16.0 (BioC 3.13):
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- No significant updates.
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---
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biotmle 1.15.0:
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- No significant updates.
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---
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biotmle 1.14.0 (BioC 3.12):
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- No significant updates.
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---
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biotmle 1.13.0:
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- No significant updates.
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---
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biotmle 1.12.0:
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- No significant updates.
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---
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biotmle 1.11.0 (BioC 3.11):
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- Change of estimation backend from the `tmle` package to the `drtmle` package.
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- Removal of option to have repeated subjects since unsupported in new backend.
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- Adds argument `bppar_debug` to facilitate debugging around parallelization.
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---
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biotmle 1.10.0 (BioC 3.10):
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- No significant updates.
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---
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biotmle 1.8.0 (BioC 3.9):
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- No significant updates.
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---
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biotmle 1.6.0 (BioC 3.8):
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- No significant updates.
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---
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biotmle 1.4.0 (BioC 3.7):
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- An updated release of this package for Bioconductor 3.7, released April 2018.
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- This release primarily implements minor changes, including the use of colors
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  in the plots produced by the visualization methods.
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---
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biotmle 1.3.0 (BioC 3.6):
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- An updated release of this package for Bioconductor 3.6, released in October
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  2017.
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- An option for applying this methodology to next-generation sequencing data has
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  been added, based on the popular "voom" transform of the limma R package.
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- Facilities for parallelized computation have been completely re-implemented:
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  current routines favor a combination of future and BiocParallel.
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- The method for estimating biomarkers based on an observed outcome has been
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  removed (temporarily). Inference based on this method requires re-thinking.
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- A full suite of unit tests have been added, covering most package functions.
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---
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biotmle 1.0.0 (BioC 3.5):
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- The first release of this package was made as part of Bioconductor 3.5, in
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  2016.
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---
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The biotmle R package provides routines for statistical methodology first
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described in the technical manuscript [1] and the software paper [2]:
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1. Nima S. Hejazi, Sara Kherad-Pajouh, Mark J. van der Laan, Alan E. Hubbard.
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   Variance stabilization of targeted sstimators of causal parameters in
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   high-dimensional settings. https://arxiv.org/abs/1710.05451
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2. Nima S. Hejazi, Weixin Cai, Alan E. Hubbard. biotmle: Targeted Learning for
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   Biomarker Discovery. The Journal of Open Source Software, 2(15), 2017.
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   https://dx.doi.org/10.21105/joss.00295
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