--- a +++ b/README.md @@ -0,0 +1,21 @@ +# ATLANTIS + +R package for biomarker/depenedency relationship discovery (via learning random forests +of conditional inference trees). + +There are two packages contained in this directory which are both necessary +to run ATLANTIS: + + - partyMod: A fork from the party package which is used to actually + build the model. The fork was necessary to include tweaks to reduce + memory necessary for training with large numbers of input + features. (See https://cran.r-project.org/web/packages/party/index.html and + "Torsten Hothorn, Peter Buehlmann, Sandrine Dudoit, Annette Molinaro and + Mark Van Der Laan (2006). Survival Ensembles. Biostatistics, 7(3), + 355--373.) + + - ATLANTIS: The wrapper around party which was used to learn the models + for the paper "Defining a Cancer Dependency Map". Includes some prefiltering + of features and biased weights more heavily on sensitive lines. See + the paper for more details on the specific settings used for each MDP + class.