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5px;overflow:hidden;background-color:#e5e5e5;border-bottom:1px solid #fff} +.dropdown-menu>li>a{display:block;padding:3px 20px;clear:both;font-weight:normal;line-height:20px;color:#333;white-space:nowrap} +.dropdown-menu>li>a:hover,.dropdown-menu>li>a:focus,.dropdown-submenu:hover>a,.dropdown-submenu:focus>a{text-decoration:none;color:#fff;background-color:#0081c2;background-image:-moz-linear-gradient(top, #08c, #0077b3);background-image:-webkit-gradient(linear, 0 0, 0 100%, from(#08c), to(#0077b3));background-image:-webkit-linear-gradient(top, #08c, #0077b3);background-image:-o-linear-gradient(top, #08c, #0077b3);background-image:linear-gradient(to bottom, #08c, #0077b3);background-repeat:repeat-x;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='#ff0088cc', endColorstr='#ff0077b3', GradientType=0)} 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";float:right;width:0;height:0;border-color:transparent;border-style:solid;border-width:5px 0 5px 5px;border-left-color:#ccc;margin-top:5px;margin-right:-10px} +.dropdown-submenu:hover>a:after{border-left-color:#fff} +.dropdown-submenu.pull-left{float:none}.dropdown-submenu.pull-left>.dropdown-menu{left:-100%;margin-left:10px;border-radius:6px 0 6px 6px;-webkit-border-radius:6px 0 6px 6px;-moz-border-radius:6px 0 6px 6px;border-radius:6px 0 6px 6px} +.dropdown .dropdown-menu .nav-header{padding-left:20px;padding-right:20px} +.typeahead{z-index:1051;margin-top:2px;border-radius:4px;-webkit-border-radius:4px;-moz-border-radius:4px;border-radius:4px} +.well{min-height:20px;padding:19px;margin-bottom:20px;background-color:#f5f5f5;border:1px solid #e3e3e3;-webkit-border-radius:4px;-moz-border-radius:4px;border-radius:4px;-webkit-box-shadow:inset 0 1px 1px rgba(0,0,0,0.05);-moz-box-shadow:inset 0 1px 1px rgba(0,0,0,0.05);box-shadow:inset 0 1px 1px rgba(0,0,0,0.05)}.well blockquote{border-color:#ddd;border-color:rgba(0,0,0,0.15)} +.well-large{padding:24px;border-radius:6px;-webkit-border-radius:6px;-moz-border-radius:6px;border-radius:6px} +.well-small{padding:9px;border-radius:3px;-webkit-border-radius:3px;-moz-border-radius:3px;border-radius:3px} +.fade{opacity:0;-webkit-transition:opacity .15s linear;-moz-transition:opacity .15s linear;-o-transition:opacity .15s linear;transition:opacity .15s linear}.fade.in{opacity:1} +.collapse{position:relative;height:0;overflow:hidden;-webkit-transition:height .35s ease;-moz-transition:height .35s ease;-o-transition:height .35s ease;transition:height .35s ease}.collapse.in{height:auto} +.close{float:right;font-size:20px;font-weight:bold;line-height:20px;color:#000;text-shadow:0 1px 0 #fff;opacity:.2;filter:alpha(opacity=20)}.close:hover,.close:focus{color:#000;text-decoration:none;cursor:pointer;opacity:.4;filter:alpha(opacity=40)} 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rgba(0,0,0,0.15);box-shadow:inset 0 -1px 0 rgba(0,0,0,0.15);-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box;-webkit-transition:width .6s ease;-moz-transition:width .6s ease;-o-transition:width .6s ease;transition:width .6s ease} +.progress .bar+.bar{-webkit-box-shadow:inset 1px 0 0 rgba(0,0,0,.15), inset 0 -1px 0 rgba(0,0,0,.15);-moz-box-shadow:inset 1px 0 0 rgba(0,0,0,.15), inset 0 -1px 0 rgba(0,0,0,.15);box-shadow:inset 1px 0 0 rgba(0,0,0,.15), inset 0 -1px 0 rgba(0,0,0,.15)} +.progress-striped .bar{background-color:#149bdf;background-image:-webkit-gradient(linear, 0 100%, 100% 0, color-stop(.25, rgba(255,255,255,0.15)), color-stop(.25, transparent), color-stop(.5, transparent), color-stop(.5, rgba(255,255,255,0.15)), color-stop(.75, rgba(255,255,255,0.15)), color-stop(.75, transparent), to(transparent));background-image:-webkit-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, 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infinite;animation:progress-bar-stripes 2s linear infinite} +.progress-danger .bar,.progress .bar-danger{background-color:#dd514c;background-image:-moz-linear-gradient(top, #ee5f5b, #c43c35);background-image:-webkit-gradient(linear, 0 0, 0 100%, from(#ee5f5b), to(#c43c35));background-image:-webkit-linear-gradient(top, #ee5f5b, #c43c35);background-image:-o-linear-gradient(top, #ee5f5b, #c43c35);background-image:linear-gradient(to bottom, #ee5f5b, #c43c35);background-repeat:repeat-x;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='#ffee5f5b', endColorstr='#ffc43c35', GradientType=0)} +.progress-danger.progress-striped .bar,.progress-striped .bar-danger{background-color:#ee5f5b;background-image:-webkit-gradient(linear, 0 100%, 100% 0, color-stop(.25, rgba(255,255,255,0.15)), color-stop(.25, transparent), color-stop(.5, transparent), color-stop(.5, rgba(255,255,255,0.15)), color-stop(.75, rgba(255,255,255,0.15)), color-stop(.75, transparent), 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to(#57a957));background-image:-webkit-linear-gradient(top, #62c462, #57a957);background-image:-o-linear-gradient(top, #62c462, #57a957);background-image:linear-gradient(to bottom, #62c462, #57a957);background-repeat:repeat-x;filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='#ff62c462', endColorstr='#ff57a957', GradientType=0)} +.progress-success.progress-striped .bar,.progress-striped .bar-success{background-color:#62c462;background-image:-webkit-gradient(linear, 0 100%, 100% 0, color-stop(.25, rgba(255,255,255,0.15)), color-stop(.25, transparent), color-stop(.5, transparent), color-stop(.5, rgba(255,255,255,0.15)), color-stop(.75, rgba(255,255,255,0.15)), color-stop(.75, transparent), to(transparent));background-image:-webkit-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-image:-moz-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, 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endColorstr='#ff339bb9', GradientType=0)} +.progress-info.progress-striped .bar,.progress-striped .bar-info{background-color:#5bc0de;background-image:-webkit-gradient(linear, 0 100%, 100% 0, color-stop(.25, rgba(255,255,255,0.15)), color-stop(.25, transparent), color-stop(.5, transparent), color-stop(.5, rgba(255,255,255,0.15)), color-stop(.75, rgba(255,255,255,0.15)), color-stop(.75, transparent), to(transparent));background-image:-webkit-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-image:-moz-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-image:-o-linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, 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#e5e5e5;border-radius:4px;-webkit-border-radius:4px;-moz-border-radius:4px;border-radius:4px} +.accordion-heading{border-bottom:0} +.accordion-heading .accordion-toggle{display:block;padding:8px 15px} +.accordion-toggle{cursor:pointer} +.accordion-inner{padding:9px 15px;border-top:1px solid #e5e5e5} +.carousel{position:relative;margin-bottom:20px;line-height:1} +.carousel-inner{overflow:hidden;width:100%;position:relative} +.carousel-inner>.item{display:none;position:relative;-webkit-transition:.6s ease-in-out left;-moz-transition:.6s ease-in-out left;-o-transition:.6s ease-in-out left;transition:.6s ease-in-out left}.carousel-inner>.item>img,.carousel-inner>.item>a>img{display:block;line-height:1} +.carousel-inner>.active,.carousel-inner>.next,.carousel-inner>.prev{display:block} +.carousel-inner>.active{left:0} +.carousel-inner>.next,.carousel-inner>.prev{position:absolute;top:0;width:100%} +.carousel-inner>.next{left:100%} +.carousel-inner>.prev{left:-100%} 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+@media (min-width:768px) and (max-width:979px){.hidden-desktop{display:inherit !important} .visible-desktop{display:none !important} .visible-tablet{display:inherit !important} .hidden-tablet{display:none !important}}@media (max-width:767px){.hidden-desktop{display:inherit !important} .visible-desktop{display:none !important} .visible-phone{display:inherit !important} .hidden-phone{display:none !important}}.visible-print{display:none !important} +@media print{.visible-print{display:inherit !important} .hidden-print{display:none !important}}@media (min-width:1200px){.row{margin-left:-30px;*zoom:1}.row:before,.row:after{display:table;content:"";line-height:0} .row:after{clear:both} [class*="span"]{float:left;min-height:1px;margin-left:30px} .container,.navbar-static-top .container,.navbar-fixed-top .container,.navbar-fixed-bottom .container{width:1170px} .span12{width:1170px} .span11{width:1070px} .span10{width:970px} .span9{width:870px} .span8{width:770px} .span7{width:670px} 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+.icon-sort-by-order:before{content:"\f162"} +.icon-sort-by-order-alt:before{content:"\f163"} +.icon-thumbs-up:before{content:"\f164"} +.icon-thumbs-down:before{content:"\f165"} +.icon-youtube-sign:before{content:"\f166"} +.icon-youtube:before{content:"\f167"} +.icon-xing:before{content:"\f168"} +.icon-xing-sign:before{content:"\f169"} +.icon-youtube-play:before{content:"\f16a"} +.icon-dropbox:before{content:"\f16b"} +.icon-stackexchange:before{content:"\f16c"} +.icon-instagram:before{content:"\f16d"} +.icon-flickr:before{content:"\f16e"} +.icon-adn:before{content:"\f170"} +.icon-bitbucket:before{content:"\f171"} +.icon-bitbucket-sign:before{content:"\f172"} +.icon-tumblr:before{content:"\f173"} +.icon-tumblr-sign:before{content:"\f174"} +.icon-long-arrow-down:before{content:"\f175"} +.icon-long-arrow-up:before{content:"\f176"} +.icon-long-arrow-left:before{content:"\f177"} +.icon-long-arrow-right:before{content:"\f178"} +.icon-apple:before{content:"\f179"} 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+.hbox{display:-webkit-box;-webkit-box-orient:horizontal;-webkit-box-align:stretch;display:-moz-box;-moz-box-orient:horizontal;-moz-box-align:stretch;display:box;box-orient:horizontal;box-align:stretch;display:flex;flex-direction:row;align-items:stretch} +.hbox>*{-webkit-box-flex:0;-moz-box-flex:0;box-flex:0;flex:none} +.vbox{display:-webkit-box;-webkit-box-orient:vertical;-webkit-box-align:stretch;display:-moz-box;-moz-box-orient:vertical;-moz-box-align:stretch;display:box;box-orient:vertical;box-align:stretch;display:flex;flex-direction:column;align-items:stretch} +.vbox>*{-webkit-box-flex:0;-moz-box-flex:0;box-flex:0;flex:none} +.hbox.reverse,.vbox.reverse,.reverse{-webkit-box-direction:reverse;-moz-box-direction:reverse;box-direction:reverse;flex-direction:row-reverse} +.hbox.box-flex0,.vbox.box-flex0,.box-flex0{-webkit-box-flex:0;-moz-box-flex:0;box-flex:0;flex:none;width:auto} +.hbox.box-flex1,.vbox.box-flex1,.box-flex1{-webkit-box-flex:1;-moz-box-flex:1;box-flex:1;flex:1} +.hbox.box-flex,.vbox.box-flex,.box-flex{-webkit-box-flex:1;-moz-box-flex:1;box-flex:1;flex:1} +.hbox.box-flex2,.vbox.box-flex2,.box-flex2{-webkit-box-flex:2;-moz-box-flex:2;box-flex:2;flex:2} +.box-group1{-webkit-box-flex-group:1;-moz-box-flex-group:1;box-flex-group:1} +.box-group2{-webkit-box-flex-group:2;-moz-box-flex-group:2;box-flex-group:2} +.hbox.start,.vbox.start,.start{-webkit-box-pack:start;-moz-box-pack:start;box-pack:start;justify-content:flex-start} +.hbox.end,.vbox.end,.end{-webkit-box-pack:end;-moz-box-pack:end;box-pack:end;justify-content:flex-end} +.hbox.center,.vbox.center,.center{-webkit-box-pack:center;-moz-box-pack:center;box-pack:center;justify-content:center} +.hbox.align-start,.vbox.align-start,.align-start{-webkit-box-align:start;-moz-box-align:start;box-align:start;align-items:flex-start} +.hbox.align-end,.vbox.align-end,.align-end{-webkit-box-align:end;-moz-box-align:end;box-align:end;align-items:flex-end} +.hbox.align-center,.vbox.align-center,.align-center{-webkit-box-align:center;-moz-box-align:center;box-align:center;align-items:center} +div.error{margin:2em;text-align:center} +div.error>h1{font-size:500%;line-height:normal} +div.error>p{font-size:200%;line-height:normal} +div.traceback-wrapper{text-align:left;max-width:800px;margin:auto} +body{background-color:#fff;position:absolute;left:0;right:0;top:0;bottom:0;overflow:visible} +div#header{display:none} +#ipython_notebook{padding-left:16px} +#noscript{width:auto;padding-top:16px;padding-bottom:16px;text-align:center;font-size:22px;color:#f00;font-weight:bold} +#ipython_notebook img{font-family:Verdana,"Helvetica Neue",Arial,Helvetica,Geneva,sans-serif;height:24px;text-decoration:none;color:#000} +#site{width:100%;display:none} +.ui-button .ui-button-text{padding:.2em .8em;font-size:77%} +input.ui-button{padding:.3em .9em} +.navbar span{margin-top:3px} +span#login_widget{float:right} +.nav-header{text-transform:none} +.navbar-nobg{background-color:transparent;background-image:none} +#header>span{margin-top:10px} +.modal_stretch{display:-webkit-box;-webkit-box-orient:vertical;-webkit-box-align:stretch;display:-moz-box;-moz-box-orient:vertical;-moz-box-align:stretch;display:box;box-orient:vertical;box-align:stretch;display:flex;flex-direction:column;align-items:stretch;height:80%}.modal_stretch .modal-body{max-height:none;flex:1} +@media (min-width:768px){.modal{width:700px;margin-left:-350px}}.center-nav{display:inline-block;margin-bottom:-4px} +.alternate_upload{background-color:none;display:inline} +.alternate_upload.form{padding:0;margin:0} +.alternate_upload input.fileinput{background-color:#f00;position:relative;opacity:0;z-index:2;width:295px;margin-left:163px;cursor:pointer;height:26px} +ul#tabs{margin-bottom:4px} +ul#tabs a{padding-top:4px;padding-bottom:4px} +ul.breadcrumb a:focus,ul.breadcrumb a:hover{text-decoration:none} +ul.breadcrumb i.icon-home{font-size:16px;margin-right:4px} 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<div class="input_area"> +<div class="highlight"><pre><span class="kn">import</span> <span class="nn">numpy</span> <span class="kn">as</span> <span class="nn">np</span> +<span class="kn">import</span> <span class="nn">pandas</span> <span class="kn">as</span> <span class="nn">pd</span> +<span class="kn">import</span> <span class="nn">matplotlib.pyplot</span> <span class="kn">as</span> <span class="nn">plt</span> +<span class="kn">import</span> <span class="nn">seaborn</span> +<span class="kn">from</span> <span class="nn">matplotlib</span> <span class="kn">import</span> <span class="n">rcParams</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"figure.figsize"</span><span class="p">]</span> <span class="o">=</span> <span class="p">(</span><span class="mi">14</span><span class="p">,</span> <span class="mi">8</span><span class="p">)</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"xtick.labelsize"</span><span class="p">]</span> <span class="o">=</span> <span class="mi">12</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"ytick.labelsize"</span><span class="p">]</span> <span class="o">=</span> <span class="mi">12</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"font.size"</span><span class="p">]</span> <span class="o">=</span> <span class="mi">14</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"axes.titlesize"</span><span class="p">]</span> <span class="o">=</span> <span class="mi">16</span> +<span class="c">#rcParams["text.usetex"] = False</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"font.family"</span><span class="p">]</span> <span class="o">=</span> <span class="s">"Serif"</span> +<span class="n">rcParams</span><span class="p">[</span><span class="s">"figure.dpi"</span><span class="p">]</span> <span class="o">=</span> <span class="mi">600</span> + + +<span class="n">a</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">read_csv</span><span class="p">(</span><span class="s">"../data/villagebay_population.csv"</span><span class="p">)</span> +<span class="n">b</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">read_csv</span><span class="p">(</span><span class="s">"../data/exposure.csv"</span><span class="p">)</span> + +<span class="n">fig</span><span class="p">,</span> <span class="p">(</span><span class="n">ax</span><span class="p">,</span> <span class="n">ax2</span><span class="p">)</span> <span class="o">=</span> <span class="n">plt</span><span class="o">.</span><span class="n">subplots</span><span class="p">(</span><span class="mi">2</span><span class="p">,</span> <span class="mi">1</span><span class="p">,</span> <span class="n">sharex</span><span class="o">=</span><span class="bp">True</span><span class="p">)</span> + +<span class="c">#ax = plt.subplot(211)</span> +<span class="n">ax</span><span class="o">.</span><span class="n">plot</span><span class="p">(</span><span class="n">a</span><span class="o">.</span><span class="n">Year</span><span class="p">,</span> <span class="n">a</span><span class="o">.</span><span class="n">VillageBay</span><span class="p">,</span> <span class="n">c</span><span class="o">=</span><span class="n">seaborn</span><span class="o">.</span><span class="n">color_palette</span><span class="p">(</span><span class="s">"deep"</span><span class="p">,</span> <span class="mi">8</span><span class="p">)[</span><span class="mi">0</span><span class="p">],</span> <span class="n">lw</span><span class="o">=</span><span class="mi">3</span><span class="p">)</span> +<span class="n">ax</span><span class="o">.</span><span class="n">scatter</span><span class="p">(</span><span class="n">a</span><span class="o">.</span><span class="n">Year</span><span class="p">,</span> <span class="n">a</span><span class="o">.</span><span class="n">VillageBay</span><span class="p">,</span> <span class="n">c</span><span class="o">=</span><span class="n">seaborn</span><span class="o">.</span><span class="n">color_palette</span><span class="p">(</span><span class="s">"deep"</span><span class="p">,</span> <span class="mi">8</span><span class="p">)[</span><span class="mi">0</span><span class="p">],</span> <span class="n">s</span><span class="o">=</span><span class="mi">50</span><span class="p">)</span> +<span class="n">ax</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s">"Village Bay Population"</span><span class="p">)</span> +<span class="n">ax</span><span class="o">.</span><span class="n">set_ylim</span><span class="p">([</span><span class="mi">180</span><span class="p">,</span> <span class="mi">700</span><span class="p">])</span> + + +<span class="c">#ax2 = plt.subplot(212, sharex=ax)</span> + +<span class="n">ax2</span><span class="o">.</span><span class="n">plot</span><span class="p">(</span><span class="n">b</span><span class="o">.</span><span class="n">BirthYear</span><span class="p">,</span> <span class="n">b</span><span class="o">.</span><span class="n">AvgOfLambWS</span><span class="p">,</span> <span class="n">c</span><span class="o">=</span><span class="n">seaborn</span><span class="o">.</span><span class="n">color_palette</span><span class="p">(</span><span class="s">"deep"</span><span class="p">,</span> <span class="mi">8</span><span class="p">)[</span><span class="mi">2</span><span class="p">],</span> <span class="n">lw</span><span class="o">=</span><span class="mi">3</span><span class="p">)</span> +<span class="n">ax2</span><span class="o">.</span><span class="n">scatter</span><span class="p">(</span><span class="n">b</span><span class="o">.</span><span class="n">BirthYear</span><span class="p">,</span> <span class="n">b</span><span class="o">.</span><span class="n">AvgOfLambWS</span><span class="p">,</span> <span class="n">c</span><span class="o">=</span><span class="n">seaborn</span><span class="o">.</span><span class="n">color_palette</span><span class="p">(</span><span class="s">"deep"</span><span class="p">,</span> <span class="mi">8</span><span class="p">)[</span><span class="mi">2</span><span class="p">],</span> <span class="n">s</span><span class="o">=</span><span class="mi">50</span><span class="p">)</span> +<span class="n">ax2</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s">"Lamb Winter Survival"</span><span class="p">)</span> +<span class="n">ax2</span><span class="o">.</span><span class="n">set_xlim</span><span class="p">([</span><span class="mf">1984.5</span><span class="p">,</span> <span class="mf">2013.5</span><span class="p">])</span> +<span class="n">ax2</span><span class="o">.</span><span class="n">set_ylim</span><span class="p">([</span><span class="mi">0</span><span class="p">,</span> <span class="mf">0.8</span><span class="p">])</span> + +<span class="n">plt</span><span class="o">.</span><span class="n">savefig</span><span class="p">(</span><span class="s">"figures/population2.jpg"</span><span class="p">,</span> <span class="n">dpi</span><span class="o">=</span><span class="mi">300</span><span class="p">,</span> <span class="n">jpeg_quality</span><span class="o">=</span><span class="mi">100</span><span class="p">)</span> +</pre></div> + +</div> +</div> +</div> + +</div> + </div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h1 id="Robust-Extraction-of-Quantitative-Information-from-Histology-Images">Robust Extraction of Quantitative Information from Histology Images<a class="anchor-link" href="#Robust-Extraction-of-Quantitative-Information-from-Histology-Images">¶</a></h1> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h4 id="Quentin-Caudron">Quentin Caudron<a class="anchor-link" href="#Quentin-Caudron">¶</a></h4> +</div> +</div> +</div> +</section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="The-Soay-Sheep">The Soay Sheep<a class="anchor-link" href="#The-Soay-Sheep">¶</a></h2> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/soay.jpg" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/population2.jpg" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/lit1.jpg" /></p> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/lit2.jpg" /></p> +</div> +</div> +</div> + </div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/lit4.jpg" /></p> +</div> +</div> +</div> + </div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Outline">Outline<a class="anchor-link" href="#Outline">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>Methods and data collection</li> +<li>Image processing</li> +<li>Extracted measures</li> +<li>Preliminary analysis</li> +<li>Future directions</li> +</ul> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Data">Data<a class="anchor-link" href="#Data">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><strong>In the field, winter of 2011 - 2012 :</strong></p> +<ul> +<li>Daily study area monitoring for deaths</li> +<li>143 liver samples collected within a day of death</li> +</ul> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><strong>In the lab :</strong></p> +<ul> +<li>Sectioning after paraffin treatment</li> +<li>H&E staining of about 1000 slides</li> +</ul> +</div> +</div> +</div> + </div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><strong>Analysis :</strong></p> +<ul> +<li>Pathology standard : semi-quantitative scoring</li> +<li>Image processing</li> +</ul> +</div> +</div> +</div> + </div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="the-field-copy-">The Field ©</h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Sweat-and-blood-collected in cold, cold Scotland.</p> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Eight physical measurements :</p> +<ul> +<li>Age at death</li> +<li>Weight</li> +<li>Sex</li> +<li>Limb length</li> +<li>Environmental "stress"</li> +</ul> +</div> +</div> +</div> + </div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="Clinical-Pathology">Clinical Pathology<a class="anchor-link" href="#Clinical-Pathology">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Operator-driven visual analysis of 98 slides under microscopy.</p> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Eleven discrete and continuous measures :</p> +<ul> +<li>Inflammation</li> +<li>Necrosis</li> +<li>Apoptosis</li> +<li>Hyperplasia</li> +<li>Fibrosis</li> +<li>Hepatitis</li> +</ul> +</div> +</div> +</div> + </div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="Image-Processing">Image Processing<a class="anchor-link" href="#Image-Processing">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Automated analysis of 4430 images of slides representing 143 sheep.</p> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Seven structural and textural measures with varying levels of biological interpretation :</p> +<ul> +<li>Inflammation</li> +<li>Hyperplasia / tissue density</li> +<li>Best-guess proxies for "generic degeneration"</li> +</ul> +</div> +</div> +</div> + </div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Image-Processing">Image Processing<a class="anchor-link" href="#Image-Processing">¶</a></h2> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/sheep.jpg"></img></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/processed.jpg"></img></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="The-Challenge">The Challenge<a class="anchor-link" href="#The-Challenge">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><strong>Information extraction must be</strong></p> +<ul> +<li>automagical - no operator input</li> +<li>reasonably quick - restricted computing time</li> +<li>robust - invariant to slicing, staining, field-related variation </li> +<li>unbiased - same algorithms for everyone</li> +</ul> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/robust3.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/robust4.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/robust1.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/robust2.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/gif.gif"></img></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Structural-and-Textural-Measures">Structural and Textural Measures<a class="anchor-link" href="#Structural-and-Textural-Measures">¶</a></h2> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>characteristic <strong>scale</strong> of sinusoid widths</li> +<li><strong>directional</strong> amplitude of preferred sinusoid alignment</li> +<li><strong>tissue to sinusoid</strong> ratio</li> +<li><strong>count</strong> of inflammatory foci per image</li> +<li><strong>mean size</strong> of inflammatory foci per image</li> +<li>information <strong>entropy</strong> of sinusoid distribution</li> +<li><strong>lacunarity</strong> ( clustering ) of sinusoids</li> +</ul> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/intra.png" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/inter2.png" alt="image"></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Exploratory-Analysis">Exploratory Analysis<a class="anchor-link" href="#Exploratory-Analysis">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="by-individual">by individual<a class="anchor-link" href="#by-individual">¶</a></h3> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/lm-0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/PortalInflammation/lm-0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/PortalInflammation/lm-1.png" /></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Exploratory-Analysis">Exploratory Analysis<a class="anchor-link" href="#Exploratory-Analysis">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="controlled-for-age-/-cohort">controlled for age / cohort<a class="anchor-link" href="#controlled-for-age-/-cohort">¶</a></h3> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/PortalInflammation/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/mm_1.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/TawfikTotal/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/Fibrosis/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/PortalInflammation/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/Hindleg/mm_0.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/Weight/mm_0.png" /></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Further-analysis">Further analysis<a class="anchor-link" href="#Further-analysis">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="Age-or-cohort-effect-?">Age or cohort effect ?<a class="anchor-link" href="#Age-or-cohort-effect-?">¶</a></h3> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/mm_coefs_color_E.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/mm_coefs_color_CES.png" /></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/regressions/BDHyperplasia/mm_coefs_color_RES.png" /></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Conclusions">Conclusions<a class="anchor-link" href="#Conclusions">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>our image measures capture <strong>relevant</strong> and <strong>useful</strong> information</li> +<li>a number of correlations can be <strong>explained</strong> biologically</li> +<li>underlying <strong>structure</strong> in the data needs thought</li> +<li>still no <strong>map</strong> from image or histological measures to condition of individual</li> +</ul> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="Future-directions">Future directions<a class="anchor-link" href="#Future-directions">¶</a></h2> +</div> +</div> +</div> +</section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="Further-exploration-of-the-dataset">Further exploration of the dataset<a class="anchor-link" href="#Further-exploration-of-the-dataset">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>145 sheep ( 89 females )</li> +<li>12 age classes</li> +<li>potential redundancy in various measures</li> +</ul> +</div> +</div> +</div><div class="fragment"> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>4460 entries across 27 variables</li> +<li>3330 with full image and histological information</li> +<li>1196 for which <strong>complete</strong> information is available</li> +</ul> +</div> +</div> +</div> + </div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="More-data">More data<a class="anchor-link" href="#More-data">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>nutritional information</li> +<li>immunity data</li> +</ul> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h3 id="Narrow-field-images">Narrow-field images<a class="anchor-link" href="#Narrow-field-images">¶</a></h3> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<ul> +<li>12536 images</li> +<li>spatial distribution of nuclei</li> +</ul> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/10.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/Processed2.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/Segmented.jpg" alt="image"></p> +</div> +</div> +</div></section><section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p><img src="figures/graphics/10x.png" width=100%></src></p> +</div> +</div> +</div></section> + </section><section> + <section> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<h2 id="With-thanks-to">With thanks to<a class="anchor-link" href="#With-thanks-to">¶</a></h2> +</div> +</div> +</div> + +<div class="cell border-box-sizing text_cell rendered"> +<div class="prompt input_prompt"> +</div> +<div class="inner_cell"> +<div class="text_cell_render border-box-sizing rendered_html"> +<p>Romain Garnier</p> +<p>Andrea Graham</p> +<p>Tawfik Aboellail (CSU)</p> +<p>Bryan Grenfell</p> +</div> +</div> +</div> +</div> +</div> + +<script src="reveal.js/lib/js/head.min.js"></script> + +<script src="reveal.js/js/reveal.js"></script> + +<script> + +// Full list of configuration options available here: https://github.com/hakimel/reveal.js#configuration +Reveal.initialize({ +controls: true, +progress: true, +history: true, + +theme: Reveal.getQueryHash().theme, // available themes are in /css/theme +transition: Reveal.getQueryHash().transition || 'linear', // default/cube/page/concave/zoom/linear/none + +// Optional libraries used to 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