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| a | b/DEMO/oneliner-3CLpro-finetuning-AID1706.ipynb | ||
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| 1 | { |
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| 2 | "cells": [ |
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| 3 | { |
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| 4 | "cell_type": "code", |
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| 5 | "execution_count": 1, |
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| 6 | "metadata": {}, |
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| 7 | "outputs": [], |
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| 8 | "source": [ |
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| 9 | "import os\n", |
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| 10 | "os.chdir('../')" |
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| 11 | ] |
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| 12 | }, |
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| 13 | { |
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| 14 | "cell_type": "code", |
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| 15 | "execution_count": 2, |
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| 16 | "metadata": {}, |
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| 17 | "outputs": [], |
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| 18 | "source": [ |
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| 19 | "import DeepPurpose.oneliner as oneliner\n", |
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| 20 | "from DeepPurpose import dataset" |
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| 21 | ] |
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| 22 | }, |
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| 23 | { |
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| 24 | "cell_type": "code", |
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| 25 | "execution_count": 3, |
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| 26 | "metadata": {}, |
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| 27 | "outputs": [ |
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| 28 | { |
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| 29 | "name": "stdout", |
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| 30 | "output_type": "stream", |
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| 31 | "text": [ |
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| 32 | "Beginning Processing...\n" |
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| 33 | ] |
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| 34 | }, |
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| 35 | { |
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| 36 | "name": "stderr", |
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| 37 | "output_type": "stream", |
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| 38 | "text": [ |
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| 39 | "/home/kh278/.conda/envs/DeepPurpose/lib/python3.7/site-packages/IPython/core/interactiveshell.py:3254: DtypeWarning: Columns (0,7) have mixed types.Specify dtype option on import or set low_memory=False.\n", |
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| 40 | " if (await self.run_code(code, result, async_=asy)):\n", |
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| 41 | "/home/kh278/DeepPurpose/dataset.py:224: SettingWithCopyWarning: \n", |
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| 42 | "A value is trying to be set on a copy of a slice from a DataFrame\n", |
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| 43 | "\n", |
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| 44 | "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", |
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| 45 | " val['binary_label'][(val.PUBCHEM_ACTIVITY_SCORE >= threshold) & (val.PUBCHEM_ACTIVITY_SCORE <=100)] = 1\n" |
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| 46 | ] |
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| 47 | }, |
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| 48 | { |
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| 49 | "name": "stdout", |
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| 50 | "output_type": "stream", |
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| 51 | "text": [ |
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| 52 | "Default binary threshold for the binding affinity scores is 15, recommended by the investigator\n", |
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| 53 | "Done!\n" |
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| 54 | ] |
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| 55 | } |
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| 56 | ], |
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| 57 | "source": [ |
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| 58 | "target, target_name = dataset.load_SARS_CoV_Protease_3CL()\n", |
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| 59 | "train_drug, train_target, train_y = dataset.load_AID1706_SARS_CoV_3CL('./data', seed = 1234)\n", |
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| 60 | "X_repurpose, drug_names, drug_CID = dataset.load_antiviral_drugs('./data')" |
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| 61 | ] |
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| 62 | }, |
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| 63 | { |
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| 64 | "cell_type": "code", |
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| 65 | "execution_count": 4, |
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| 66 | "metadata": {}, |
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| 67 | "outputs": [ |
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| 68 | { |
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| 69 | "data": { |
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| 70 | "text/plain": [ |
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| 71 | "26640" |
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| 72 | ] |
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| 73 | }, |
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| 74 | "execution_count": 4, |
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| 75 | "metadata": {}, |
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| 76 | "output_type": "execute_result" |
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| 77 | } |
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| 78 | ], |
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| 79 | "source": [ |
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| 80 | "len(train_drug)" |
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| 81 | ] |
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| 82 | }, |
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| 83 | { |
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| 84 | "cell_type": "code", |
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| 85 | "execution_count": 5, |
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| 86 | "metadata": {}, |
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| 87 | "outputs": [ |
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| 88 | { |
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| 89 | "data": { |
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| 90 | "text/plain": [ |
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| 91 | "'SGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVLGKFSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAVANAETPKYKFVKANCGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQPKWLESTTVSIEDYNRWASDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKSAQWGSDPILGQYNFEDELTPESVFNQVGGVRLQ'" |
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| 92 | ] |
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| 93 | }, |
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| 94 | "execution_count": 5, |
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| 95 | "metadata": {}, |
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| 96 | "output_type": "execute_result" |
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| 97 | } |
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| 98 | ], |
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| 99 | "source": [ |
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| 100 | "target" |
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| 101 | ] |
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| 102 | }, |
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| 103 | { |
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| 104 | "cell_type": "code", |
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| 105 | "execution_count": 6, |
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| 106 | "metadata": {}, |
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| 107 | "outputs": [ |
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| 108 | { |
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| 109 | "data": { |
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| 110 | "text/plain": [ |
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| 111 | "82" |
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| 112 | ] |
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| 113 | }, |
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| 114 | "execution_count": 6, |
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| 115 | "metadata": {}, |
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| 116 | "output_type": "execute_result" |
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| 117 | } |
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| 118 | ], |
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| 119 | "source": [ |
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| 120 | "len(X_repurpose)" |
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| 121 | ] |
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| 122 | }, |
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| 123 | { |
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| 124 | "cell_type": "code", |
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| 125 | "execution_count": 4, |
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| 126 | "metadata": { |
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| 127 | "scrolled": false |
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| 128 | }, |
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| 129 | "outputs": [ |
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| 130 | { |
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| 131 | "name": "stdout", |
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| 132 | "output_type": "stream", |
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| 133 | "text": [ |
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| 134 | "Loading customized repurposing dataset...\n", |
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| 135 | "Checking if pretrained directory is valid...\n", |
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| 136 | "Beginning to load the pretrained models...\n", |
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| 137 | "Training on your own customized data...\n", |
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| 138 | "in total: 26640 drug-target pairs\n", |
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| 139 | "encoding drug...\n", |
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| 140 | "unique drugs: 13763\n", |
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| 141 | "drug encoding finished...\n", |
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| 142 | "encoding protein...\n", |
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| 143 | "unique target sequence: 1\n", |
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| 144 | "protein encoding finished...\n", |
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| 145 | "splitting dataset...\n", |
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| 146 | "Done.\n", |
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| 147 | "Use pretrained model...\n", |
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| 148 | "Begin to train model 0 with drug encoding MPNN and target encoding CNN\n", |
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| 149 | "Let's use 1 GPU!\n", |
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| 150 | "--- Data Preparation ---\n", |
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| 151 | "--- Go for Training ---\n", |
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| 152 | "Training at Epoch 1 iteration 0 with loss 2.8952746. Total time 0.0005555555555555556 hours\n", |
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| 153 | "Training at Epoch 1 iteration 100 with loss 0.6925026. Total time 0.014444444444444444 hours\n", |
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| 154 | "Validation at Epoch 1 , AUROC: 0.6995096436744034 , AUPRC: 0.07429036106716293 , F1: 0.08396124865446716\n", |
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| 155 | "Training at Epoch 2 iteration 0 with loss 0.68295914. Total time 0.025277777777777777 hours\n", |
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| 156 | "Training at Epoch 2 iteration 100 with loss 0.567375. Total time 0.03916666666666667 hours\n", |
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| 157 | "Validation at Epoch 2 , AUROC: 0.7209055246812683 , AUPRC: 0.12848468929504223 , F1: 0.10101010101010101\n", |
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| 158 | "Training at Epoch 3 iteration 0 with loss 0.59396875. Total time 0.05 hours\n", |
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| 159 | "Training at Epoch 3 iteration 100 with loss 0.4412401. Total time 0.06416666666666666 hours\n", |
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| 160 | "Validation at Epoch 3 , AUROC: 0.7587446878064726 , AUPRC: 0.14443723893655566 , F1: 0.1174496644295302\n", |
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| 161 | "Training at Epoch 4 iteration 0 with loss 0.5402388. Total time 0.075 hours\n", |
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| 162 | "Training at Epoch 4 iteration 100 with loss 0.38675064. Total time 0.08944444444444444 hours\n", |
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| 163 | "Validation at Epoch 4 , AUROC: 0.7593494606080418 , AUPRC: 0.16392332687442315 , F1: 0.12144212523719165\n", |
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| 164 | "Training at Epoch 5 iteration 0 with loss 0.44713253. Total time 0.09972222222222223 hours\n", |
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| 165 | "Training at Epoch 5 iteration 100 with loss 0.24516244. Total time 0.11333333333333333 hours\n", |
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| 166 | "Validation at Epoch 5 , AUROC: 0.7603301732592351 , AUPRC: 0.17947622982265415 , F1: 0.21212121212121213\n", |
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| 167 | "Training at Epoch 6 iteration 0 with loss 0.16557716. Total time 0.1238888888888889 hours\n", |
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| 168 | "Training at Epoch 6 iteration 100 with loss 0.21277495. Total time 0.13805555555555554 hours\n", |
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| 169 | "Validation at Epoch 6 , AUROC: 0.7408957175547564 , AUPRC: 0.17997259784665778 , F1: 0.22222222222222224\n", |
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| 170 | "Training at Epoch 7 iteration 0 with loss 0.10328247. Total time 0.1486111111111111 hours\n", |
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| 171 | "Training at Epoch 7 iteration 100 with loss 0.12615438. Total time 0.1625 hours\n", |
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| 172 | "Validation at Epoch 7 , AUROC: 0.7407976462896371 , AUPRC: 0.19082668735539288 , F1: 0.18691588785046728\n", |
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| 173 | "Training at Epoch 8 iteration 0 with loss 0.105843976. Total time 0.17305555555555555 hours\n", |
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| 174 | "Training at Epoch 8 iteration 100 with loss 0.1473576. Total time 0.18722222222222223 hours\n", |
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| 175 | "Validation at Epoch 8 , AUROC: 0.7495096436744034 , AUPRC: 0.1829652308462767 , F1: 0.2702702702702703\n", |
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| 176 | "Training at Epoch 9 iteration 0 with loss 0.14465933. Total time 0.19777777777777777 hours\n", |
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| 177 | "Training at Epoch 9 iteration 100 with loss 0.10792859. Total time 0.21166666666666667 hours\n", |
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| 178 | "Validation at Epoch 9 , AUROC: 0.7539555410264792 , AUPRC: 0.20953143763478946 , F1: 0.2689075630252101\n", |
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| 179 | "Training at Epoch 10 iteration 0 with loss 0.13459486. Total time 0.2222222222222222 hours\n", |
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| 180 | "Training at Epoch 10 iteration 100 with loss 0.1319775. Total time 0.2361111111111111 hours\n", |
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| 181 | "Validation at Epoch 10 , AUROC: 0.7591533180778032 , AUPRC: 0.189657100281938 , F1: 0.2692307692307692\n", |
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| 182 | "--- Go for Testing ---\n", |
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| 183 | "Testing AUROC: 0.7592975041224405 , AUPRC: 0.28790599593812577 , F1: 0.29508196721311475\n", |
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| 184 | "--- Training Finished ---\n", |
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| 185 | "model training finished, now repurposing\n", |
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| 186 | "repurposing...\n", |
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| 187 | "in total: 82 drug-target pairs\n", |
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| 188 | "encoding drug...\n", |
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| 189 | "unique drugs: 81\n", |
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| 190 | "drug encoding finished...\n", |
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| 191 | "encoding protein...\n", |
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| 192 | "unique target sequence: 1\n", |
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| 193 | "protein encoding finished...\n", |
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| 194 | "Done.\n", |
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| 195 | "predicting...\n", |
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| 196 | "---------------\n", |
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| 197 | "Predictions from model 0 with drug encoding MPNN and target encoding CNN are done...\n", |
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| 198 | "in total: 26640 drug-target pairs\n", |
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| 199 | "encoding drug...\n", |
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| 200 | "unique drugs: 13763\n", |
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| 201 | "drug encoding finished...\n", |
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| 202 | "encoding protein...\n", |
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| 203 | "unique target sequence: 1\n", |
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| 204 | "protein encoding finished...\n", |
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| 205 | "splitting dataset...\n", |
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| 206 | "Done.\n", |
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| 207 | "Use pretrained model...\n", |
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| 208 | "Begin to train model 1 with drug encoding CNN and target encoding CNN\n", |
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| 209 | "Let's use 1 GPU!\n", |
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| 210 | "--- Data Preparation ---\n", |
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| 211 | "--- Go for Training ---\n", |
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| 212 | "Training at Epoch 1 iteration 0 with loss 2.584126. Total time 0.0002777777777777778 hours\n", |
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| 213 | "Training at Epoch 1 iteration 100 with loss 0.4186633. Total time 0.009166666666666667 hours\n", |
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| 214 | "Validation at Epoch 1 , AUROC: 0.6758090879372344 , AUPRC: 0.16113168673137404 , F1: 0.17391304347826086\n", |
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| 215 | "Training at Epoch 2 iteration 0 with loss 0.1285939. Total time 0.01638888888888889 hours\n", |
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| 216 | "Training at Epoch 2 iteration 100 with loss 0.10919548. Total time 0.025277777777777777 hours\n", |
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| 217 | "Validation at Epoch 2 , AUROC: 0.7251062438705459 , AUPRC: 0.258599980455743 , F1: 0.2982456140350877\n", |
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| 218 | "Training at Epoch 3 iteration 0 with loss 0.06499502. Total time 0.0325 hours\n", |
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| 219 | "Training at Epoch 3 iteration 100 with loss 0.010095321. Total time 0.04138888888888889 hours\n", |
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| 220 | "Validation at Epoch 3 , AUROC: 0.7049199084668192 , AUPRC: 0.2698421813727852 , F1: 0.2891566265060241\n", |
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| 221 | "Training at Epoch 4 iteration 0 with loss 0.03634361. Total time 0.04861111111111111 hours\n", |
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| 222 | "Training at Epoch 4 iteration 100 with loss 0.01939588. Total time 0.0575 hours\n", |
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| 223 | "Validation at Epoch 4 , AUROC: 0.6927917620137299 , AUPRC: 0.2642335712317954 , F1: 0.33766233766233766\n", |
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| 224 | "Training at Epoch 5 iteration 0 with loss 0.005858685. Total time 0.06472222222222222 hours\n", |
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| 225 | "Training at Epoch 5 iteration 100 with loss 0.08927906. Total time 0.07361111111111111 hours\n", |
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| 226 | "Validation at Epoch 5 , AUROC: 0.6933638443935927 , AUPRC: 0.29244405443483384 , F1: 0.3174603174603175\n", |
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| 227 | "Training at Epoch 6 iteration 0 with loss 0.045198068. Total time 0.08055555555555556 hours\n", |
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| 228 | "Training at Epoch 6 iteration 100 with loss 0.001047113. Total time 0.08972222222222222 hours\n", |
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| 229 | "Validation at Epoch 6 , AUROC: 0.6931350114416476 , AUPRC: 0.2874232923910023 , F1: 0.3291139240506329\n", |
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| 230 | "Training at Epoch 7 iteration 0 with loss 0.0030203862. Total time 0.09666666666666666 hours\n", |
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| 231 | "Training at Epoch 7 iteration 100 with loss 0.027002987. Total time 0.10555555555555556 hours\n", |
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| 232 | "Validation at Epoch 7 , AUROC: 0.6951945080091533 , AUPRC: 0.2685735506568612 , F1: 0.2535211267605634\n", |
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| 233 | "Training at Epoch 8 iteration 0 with loss 0.008064516. Total time 0.11277777777777778 hours\n", |
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| 234 | "Training at Epoch 8 iteration 100 with loss 0.12616996. Total time 0.12166666666666667 hours\n", |
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| 235 | "Validation at Epoch 8 , AUROC: 0.7083360575351421 , AUPRC: 0.25191111466719107 , F1: 0.2564102564102564\n", |
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| 236 | "Training at Epoch 9 iteration 0 with loss 0.06623153. Total time 0.1288888888888889 hours\n", |
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| 237 | "Training at Epoch 9 iteration 100 with loss 0.058526967. Total time 0.13777777777777778 hours\n", |
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| 238 | "Validation at Epoch 9 , AUROC: 0.7365478914677999 , AUPRC: 0.28780717333872874 , F1: 0.20118343195266275\n", |
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| 239 | "Training at Epoch 10 iteration 0 with loss 0.0101304045. Total time 0.14472222222222222 hours\n", |
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| 240 | "Training at Epoch 10 iteration 100 with loss 0.007680407. Total time 0.15361111111111111 hours\n", |
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| 241 | "Validation at Epoch 10 , AUROC: 0.6922196796338673 , AUPRC: 0.18941687371528187 , F1: 0.2413793103448276\n", |
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| 242 | "--- Go for Testing ---\n", |
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| 243 | "Testing AUROC: 0.7451451259145414 , AUPRC: 0.2479534626750703 , F1: 0.34666666666666673\n", |
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| 244 | "--- Training Finished ---\n", |
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| 245 | "model training finished, now repurposing\n", |
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| 246 | "repurposing...\n", |
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| 247 | "in total: 82 drug-target pairs\n", |
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| 248 | "encoding drug...\n", |
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| 249 | "unique drugs: 81\n", |
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| 250 | "drug encoding finished...\n", |
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| 251 | "encoding protein...\n", |
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| 252 | "unique target sequence: 1\n", |
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| 253 | "protein encoding finished...\n", |
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| 254 | "Done.\n", |
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| 255 | "predicting...\n", |
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| 256 | "---------------\n", |
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| 257 | "Predictions from model 1 with drug encoding CNN and target encoding CNN are done...\n", |
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| 258 | "in total: 26640 drug-target pairs\n", |
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| 259 | "encoding drug...\n", |
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| 260 | "unique drugs: 13763\n", |
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| 261 | "drug encoding finished...\n", |
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| 262 | "encoding protein...\n", |
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| 263 | "unique target sequence: 1\n", |
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| 264 | "protein encoding finished...\n", |
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| 265 | "splitting dataset...\n", |
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| 266 | "Done.\n", |
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| 267 | "Use pretrained model...\n", |
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| 268 | "Begin to train model 2 with drug encoding Morgan and target encoding CNN\n", |
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| 269 | "Let's use 1 GPU!\n", |
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| 270 | "--- Data Preparation ---\n", |
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| 271 | "--- Go for Training ---\n", |
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| 272 | "Training at Epoch 1 iteration 0 with loss 2.911978. Total time 0.0002777777777777778 hours\n", |
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| 273 | "Training at Epoch 1 iteration 100 with loss 0.03561001. Total time 0.0075 hours\n", |
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| 274 | "Validation at Epoch 1 , AUROC: 0.7196305982347173 , AUPRC: 0.1808075015687251 , F1: 0.1764705882352941\n", |
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| 275 | "Training at Epoch 2 iteration 0 with loss 0.0067451023. Total time 0.013055555555555556 hours\n" |
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| 276 | ] |
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| 277 | }, |
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| 278 | { |
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| 279 | "name": "stdout", |
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| 280 | "output_type": "stream", |
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| 281 | "text": [ |
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| 282 | "Training at Epoch 2 iteration 100 with loss 0.01370963. Total time 0.020277777777777777 hours\n", |
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| 283 | "Validation at Epoch 2 , AUROC: 0.7198921216083687 , AUPRC: 0.1949855759852599 , F1: 0.22950819672131148\n", |
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| 284 | "Training at Epoch 3 iteration 0 with loss 0.0064470614. Total time 0.025833333333333333 hours\n", |
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| 285 | "Training at Epoch 3 iteration 100 with loss 0.004826802. Total time 0.03305555555555555 hours\n", |
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| 286 | "Validation at Epoch 3 , AUROC: 0.6990846681922196 , AUPRC: 0.17341377712606376 , F1: 0.11538461538461539\n", |
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| 287 | "Training at Epoch 4 iteration 0 with loss 0.011522379. Total time 0.03861111111111111 hours\n", |
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| 288 | "Training at Epoch 4 iteration 100 with loss 0.0005645127. Total time 0.04583333333333333 hours\n", |
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| 289 | "Validation at Epoch 4 , AUROC: 0.7308761033017326 , AUPRC: 0.18497426992285898 , F1: 0.2222222222222222\n", |
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| 290 | "Training at Epoch 5 iteration 0 with loss 0.0129869785. Total time 0.05138888888888889 hours\n", |
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| 291 | "Training at Epoch 5 iteration 100 with loss 8.904777e-05. Total time 0.058611111111111114 hours\n", |
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| 292 | "Validation at Epoch 5 , AUROC: 0.7353873814972213 , AUPRC: 0.19498788574535375 , F1: 0.21818181818181817\n", |
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| 293 | "Training at Epoch 6 iteration 0 with loss 1.7076078e-06. Total time 0.06416666666666666 hours\n", |
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| 294 | "Training at Epoch 6 iteration 100 with loss 1.9726174e-06. Total time 0.07138888888888889 hours\n", |
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| 295 | "Validation at Epoch 6 , AUROC: 0.722213141549526 , AUPRC: 0.2354742333080753 , F1: 0.2413793103448276\n", |
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| 296 | "Training at Epoch 7 iteration 0 with loss 5.498082e-05. Total time 0.07722222222222222 hours\n", |
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| 297 | "Training at Epoch 7 iteration 100 with loss 5.269306e-06. Total time 0.08444444444444445 hours\n", |
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| 298 | "Validation at Epoch 7 , AUROC: 0.7126185027786858 , AUPRC: 0.196544071559267 , F1: 0.0784313725490196\n", |
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| 299 | "Training at Epoch 8 iteration 0 with loss 7.543782e-07. Total time 0.09 hours\n", |
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| 300 | "Training at Epoch 8 iteration 100 with loss 4.7497487e-08. Total time 0.09722222222222222 hours\n", |
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| 301 | "Validation at Epoch 8 , AUROC: 0.7126757110166719 , AUPRC: 0.19541374781276266 , F1: 0.0784313725490196\n", |
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| 302 | "Training at Epoch 9 iteration 0 with loss 6.426132e-08. Total time 0.10305555555555555 hours\n", |
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| 303 | "Training at Epoch 9 iteration 100 with loss 3.5390308e-08. Total time 0.11027777777777778 hours\n", |
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| 304 | "Validation at Epoch 9 , AUROC: 0.7128963713631906 , AUPRC: 0.19686980274043872 , F1: 0.0784313725490196\n", |
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| 305 | "Training at Epoch 10 iteration 0 with loss 1.0337705e-07. Total time 0.11611111111111111 hours\n", |
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| 306 | "Training at Epoch 10 iteration 100 with loss 2.2351756e-08. Total time 0.12333333333333334 hours\n", |
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| 307 | "Validation at Epoch 10 , AUROC: 0.7131088591042823 , AUPRC: 0.20019048121474434 , F1: 0.0784313725490196\n", |
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| 308 | "--- Go for Testing ---\n", |
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| 309 | "Testing AUROC: 0.757288314682292 , AUPRC: 0.23409765566131366 , F1: 0.2622950819672131\n", |
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| 310 | "--- Training Finished ---\n", |
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| 311 | "model training finished, now repurposing\n", |
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| 312 | "repurposing...\n", |
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| 313 | "in total: 82 drug-target pairs\n", |
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| 314 | "encoding drug...\n", |
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| 315 | "unique drugs: 81\n", |
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| 316 | "drug encoding finished...\n", |
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| 317 | "encoding protein...\n", |
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| 318 | "unique target sequence: 1\n", |
||
| 319 | "protein encoding finished...\n", |
||
| 320 | "Done.\n", |
||
| 321 | "predicting...\n", |
||
| 322 | "---------------\n", |
||
| 323 | "Predictions from model 2 with drug encoding Morgan and target encoding CNN are done...\n", |
||
| 324 | "in total: 26640 drug-target pairs\n", |
||
| 325 | "encoding drug...\n", |
||
| 326 | "unique drugs: 13763\n", |
||
| 327 | "drug encoding finished...\n", |
||
| 328 | "encoding protein...\n", |
||
| 329 | "unique target sequence: 1\n", |
||
| 330 | "-- Encoding AAC takes time. Time Reference: 24s for ~100 sequences in a CPU. Calculate your time by the unique target sequence #, instead of the entire dataset.\n", |
||
| 331 | "protein encoding finished...\n", |
||
| 332 | "splitting dataset...\n", |
||
| 333 | "Done.\n", |
||
| 334 | "Use pretrained model...\n", |
||
| 335 | "Begin to train model 3 with drug encoding Morgan and target encoding AAC\n", |
||
| 336 | "Let's use 1 GPU!\n", |
||
| 337 | "--- Data Preparation ---\n", |
||
| 338 | "--- Go for Training ---\n", |
||
| 339 | "Training at Epoch 1 iteration 0 with loss 2.957141. Total time 0.0 hours\n", |
||
| 340 | "Training at Epoch 1 iteration 100 with loss 0.09619802. Total time 0.0025 hours\n", |
||
| 341 | "Validation at Epoch 1 , AUROC: 0.696959790781301 , AUPRC: 0.19129984884488405 , F1: 0.25396825396825395\n", |
||
| 342 | "Training at Epoch 2 iteration 0 with loss 0.005710384. Total time 0.0044444444444444444 hours\n", |
||
| 343 | "Training at Epoch 2 iteration 100 with loss 0.004891664. Total time 0.006944444444444444 hours\n", |
||
| 344 | "Validation at Epoch 2 , AUROC: 0.6876757110166721 , AUPRC: 0.22760637242506973 , F1: 0.1923076923076923\n", |
||
| 345 | "Training at Epoch 3 iteration 0 with loss 0.018557834. Total time 0.008888888888888889 hours\n", |
||
| 346 | "Training at Epoch 3 iteration 100 with loss 0.00025757938. Total time 0.01138888888888889 hours\n", |
||
| 347 | "Validation at Epoch 3 , AUROC: 0.697842432167375 , AUPRC: 0.2024066056707718 , F1: 0.23728813559322035\n", |
||
| 348 | "Training at Epoch 4 iteration 0 with loss 0.0012105738. Total time 0.01361111111111111 hours\n", |
||
| 349 | "Training at Epoch 4 iteration 100 with loss 0.00030179665. Total time 0.01611111111111111 hours\n", |
||
| 350 | "Validation at Epoch 4 , AUROC: 0.7173586139261197 , AUPRC: 0.20085550875576227 , F1: 0.21428571428571427\n", |
||
| 351 | "Training at Epoch 5 iteration 0 with loss 0.00076105434. Total time 0.018055555555555554 hours\n", |
||
| 352 | "Training at Epoch 5 iteration 100 with loss 5.1199386e-06. Total time 0.020555555555555556 hours\n", |
||
| 353 | "Validation at Epoch 5 , AUROC: 0.7080254985289312 , AUPRC: 0.18557428840446735 , F1: 0.15384615384615383\n", |
||
| 354 | "Training at Epoch 6 iteration 0 with loss 0.00062145246. Total time 0.0225 hours\n", |
||
| 355 | "Training at Epoch 6 iteration 100 with loss 0.00020389628. Total time 0.025 hours\n", |
||
| 356 | "Validation at Epoch 6 , AUROC: 0.7364089571755476 , AUPRC: 0.13513679393114597 , F1: 0.22727272727272724\n", |
||
| 357 | "Training at Epoch 7 iteration 0 with loss 0.0012838377. Total time 0.02722222222222222 hours\n", |
||
| 358 | "Training at Epoch 7 iteration 100 with loss 0.0030459866. Total time 0.029722222222222223 hours\n", |
||
| 359 | "Validation at Epoch 7 , AUROC: 0.7314563582870219 , AUPRC: 0.19273655585945523 , F1: 0.2985074626865672\n", |
||
| 360 | "Training at Epoch 8 iteration 0 with loss 0.00030530244. Total time 0.03166666666666667 hours\n", |
||
| 361 | "Training at Epoch 8 iteration 100 with loss 0.0021231335. Total time 0.034166666666666665 hours\n", |
||
| 362 | "Validation at Epoch 8 , AUROC: 0.7104118993135011 , AUPRC: 0.20420166085022062 , F1: 0.1724137931034483\n", |
||
| 363 | "Training at Epoch 9 iteration 0 with loss 3.892237e-05. Total time 0.03611111111111111 hours\n", |
||
| 364 | "Training at Epoch 9 iteration 100 with loss 5.6345122e-08. Total time 0.03861111111111111 hours\n", |
||
| 365 | "Validation at Epoch 9 , AUROC: 0.711711343576332 , AUPRC: 0.1893368051121524 , F1: 0.1724137931034483\n", |
||
| 366 | "Training at Epoch 10 iteration 0 with loss 3.1664985e-08. Total time 0.04083333333333333 hours\n", |
||
| 367 | "Training at Epoch 10 iteration 100 with loss 1.2107201e-08. Total time 0.043333333333333335 hours\n", |
||
| 368 | "Validation at Epoch 10 , AUROC: 0.7113844393592678 , AUPRC: 0.18876839621699176 , F1: 0.1724137931034483\n", |
||
| 369 | "--- Go for Testing ---\n", |
||
| 370 | "Testing AUROC: 0.7526775851303971 , AUPRC: 0.30979886766026277 , F1: 0.29032258064516125\n", |
||
| 371 | "--- Training Finished ---\n", |
||
| 372 | "model training finished, now repurposing\n", |
||
| 373 | "repurposing...\n", |
||
| 374 | "in total: 82 drug-target pairs\n", |
||
| 375 | "encoding drug...\n", |
||
| 376 | "unique drugs: 81\n", |
||
| 377 | "drug encoding finished...\n", |
||
| 378 | "encoding protein...\n", |
||
| 379 | "unique target sequence: 1\n", |
||
| 380 | "-- Encoding AAC takes time. Time Reference: 24s for ~100 sequences in a CPU. Calculate your time by the unique target sequence #, instead of the entire dataset.\n", |
||
| 381 | "protein encoding finished...\n", |
||
| 382 | "Done.\n", |
||
| 383 | "predicting...\n", |
||
| 384 | "---------------\n", |
||
| 385 | "Predictions from model 3 with drug encoding Morgan and target encoding AAC are done...\n", |
||
| 386 | "in total: 26640 drug-target pairs\n", |
||
| 387 | "encoding drug...\n", |
||
| 388 | "unique drugs: 13763\n", |
||
| 389 | "drug encoding finished...\n", |
||
| 390 | "encoding protein...\n", |
||
| 391 | "unique target sequence: 1\n", |
||
| 392 | "-- Encoding AAC takes time. Time Reference: 24s for ~100 sequences in a CPU. Calculate your time by the unique target sequence #, instead of the entire dataset.\n", |
||
| 393 | "protein encoding finished...\n", |
||
| 394 | "splitting dataset...\n", |
||
| 395 | "Done.\n", |
||
| 396 | "Use pretrained model...\n", |
||
| 397 | "Begin to train model 4 with drug encoding Daylight and target encoding AAC\n", |
||
| 398 | "Let's use 1 GPU!\n", |
||
| 399 | "--- Data Preparation ---\n", |
||
| 400 | "--- Go for Training ---\n", |
||
| 401 | "Training at Epoch 1 iteration 0 with loss 2.9443107. Total time 0.0 hours\n", |
||
| 402 | "Training at Epoch 1 iteration 100 with loss 0.47150522. Total time 0.0025 hours\n", |
||
| 403 | "Validation at Epoch 1 , AUROC: 0.6874959136972867 , AUPRC: 0.17904211971409134 , F1: 0.11331444759206799\n", |
||
| 404 | "Training at Epoch 2 iteration 0 with loss 0.15898931. Total time 0.004722222222222222 hours\n", |
||
| 405 | "Training at Epoch 2 iteration 100 with loss 0.07629131. Total time 0.0075 hours\n", |
||
| 406 | "Validation at Epoch 2 , AUROC: 0.6787185354691075 , AUPRC: 0.1820356878505126 , F1: 0.2564102564102564\n", |
||
| 407 | "Training at Epoch 3 iteration 0 with loss 0.029954422. Total time 0.009722222222222222 hours\n" |
||
| 408 | ] |
||
| 409 | }, |
||
| 410 | { |
||
| 411 | "name": "stdout", |
||
| 412 | "output_type": "stream", |
||
| 413 | "text": [ |
||
| 414 | "Training at Epoch 3 iteration 100 with loss 0.08131296. Total time 0.012222222222222223 hours\n", |
||
| 415 | "Validation at Epoch 3 , AUROC: 0.6453906505393919 , AUPRC: 0.18346710639280428 , F1: 0.2823529411764706\n", |
||
| 416 | "Training at Epoch 4 iteration 0 with loss 0.027965397. Total time 0.014444444444444444 hours\n", |
||
| 417 | "Training at Epoch 4 iteration 100 with loss 0.0106874835. Total time 0.016944444444444446 hours\n", |
||
| 418 | "Validation at Epoch 4 , AUROC: 0.6764628963713631 , AUPRC: 0.18349862326064548 , F1: 0.2647058823529412\n", |
||
| 419 | "Training at Epoch 5 iteration 0 with loss 0.07962269. Total time 0.019166666666666665 hours\n", |
||
| 420 | "Training at Epoch 5 iteration 100 with loss 0.0049899057. Total time 0.021666666666666667 hours\n", |
||
| 421 | "Validation at Epoch 5 , AUROC: 0.6725073553448839 , AUPRC: 0.17377682895204807 , F1: 0.23655913978494622\n", |
||
| 422 | "Training at Epoch 6 iteration 0 with loss 0.04211598. Total time 0.02388888888888889 hours\n", |
||
| 423 | "Training at Epoch 6 iteration 100 with loss 0.008001091. Total time 0.02638888888888889 hours\n", |
||
| 424 | "Validation at Epoch 6 , AUROC: 0.7000326904217065 , AUPRC: 0.16881333805459592 , F1: 0.275\n", |
||
| 425 | "Training at Epoch 7 iteration 0 with loss 0.003507731. Total time 0.02861111111111111 hours\n", |
||
| 426 | "Training at Epoch 7 iteration 100 with loss 0.0044978675. Total time 0.03111111111111111 hours\n", |
||
| 427 | "Validation at Epoch 7 , AUROC: 0.7041353383458647 , AUPRC: 0.1856970424941901 , F1: 0.25\n", |
||
| 428 | "Training at Epoch 8 iteration 0 with loss 0.05206099. Total time 0.03333333333333333 hours\n", |
||
| 429 | "Training at Epoch 8 iteration 100 with loss 0.05816785. Total time 0.03611111111111111 hours\n", |
||
| 430 | "Validation at Epoch 8 , AUROC: 0.7108859104282446 , AUPRC: 0.1952597801380466 , F1: 0.29473684210526313\n", |
||
| 431 | "Training at Epoch 9 iteration 0 with loss 0.013554451. Total time 0.03805555555555556 hours\n", |
||
| 432 | "Training at Epoch 9 iteration 100 with loss 0.007886992. Total time 0.04083333333333333 hours\n", |
||
| 433 | "Validation at Epoch 9 , AUROC: 0.7187316116377901 , AUPRC: 0.16459869666835927 , F1: 0.27027027027027023\n", |
||
| 434 | "Training at Epoch 10 iteration 0 with loss 0.025015991. Total time 0.043055555555555555 hours\n", |
||
| 435 | "Training at Epoch 10 iteration 100 with loss 0.09150379. Total time 0.04555555555555556 hours\n", |
||
| 436 | "Validation at Epoch 10 , AUROC: 0.7168846028113762 , AUPRC: 0.2023549752538576 , F1: 0.2424242424242424\n", |
||
| 437 | "--- Go for Testing ---\n", |
||
| 438 | "Testing AUROC: 0.7601780253910315 , AUPRC: 0.2671153851194677 , F1: 0.3008849557522124\n", |
||
| 439 | "--- Training Finished ---\n", |
||
| 440 | "model training finished, now repurposing\n", |
||
| 441 | "repurposing...\n", |
||
| 442 | "in total: 82 drug-target pairs\n", |
||
| 443 | "encoding drug...\n", |
||
| 444 | "unique drugs: 81\n", |
||
| 445 | "drug encoding finished...\n", |
||
| 446 | "encoding protein...\n", |
||
| 447 | "unique target sequence: 1\n", |
||
| 448 | "-- Encoding AAC takes time. Time Reference: 24s for ~100 sequences in a CPU. Calculate your time by the unique target sequence #, instead of the entire dataset.\n", |
||
| 449 | "protein encoding finished...\n", |
||
| 450 | "Done.\n", |
||
| 451 | "predicting...\n", |
||
| 452 | "---------------\n", |
||
| 453 | "Predictions from model 4 with drug encoding Daylight and target encoding AAC are done...\n", |
||
| 454 | "models prediction finished...\n", |
||
| 455 | "aggregating results...\n", |
||
| 456 | "---------------\n", |
||
| 457 | "Drug Repurposing Result for SARS-CoV 3CL Protease\n", |
||
| 458 | "+------+----------------------+-----------------------+-------------+-------------+\n", |
||
| 459 | "| Rank | Drug Name | Target Name | Interaction | Probability |\n", |
||
| 460 | "+------+----------------------+-----------------------+-------------+-------------+\n", |
||
| 461 | "| 1 | Darunavir | SARS-CoV 3CL Protease | YES | 1.00 |\n", |
||
| 462 | "| 2 | Amprenavir | SARS-CoV 3CL Protease | YES | 1.00 |\n", |
||
| 463 | "| 3 | Efavirenz | SARS-CoV 3CL Protease | YES | 0.99 |\n", |
||
| 464 | "| 4 | Raltegravir | SARS-CoV 3CL Protease | YES | 0.99 |\n", |
||
| 465 | "| 5 | Fosamprenavir | SARS-CoV 3CL Protease | YES | 0.98 |\n", |
||
| 466 | "| 6 | Tipranavir | SARS-CoV 3CL Protease | YES | 0.98 |\n", |
||
| 467 | "| 7 | Doravirine | SARS-CoV 3CL Protease | YES | 0.97 |\n", |
||
| 468 | "| 8 | Methisazone | SARS-CoV 3CL Protease | YES | 0.95 |\n", |
||
| 469 | "| 9 | Loviride | SARS-CoV 3CL Protease | YES | 0.94 |\n", |
||
| 470 | "| 10 | Simeprevir | SARS-CoV 3CL Protease | YES | 0.93 |\n", |
||
| 471 | "| 11 | Elvitegravir | SARS-CoV 3CL Protease | YES | 0.88 |\n", |
||
| 472 | "| 12 | Vicriviroc | SARS-CoV 3CL Protease | NO | 0.43 |\n", |
||
| 473 | "| 13 | Nitazoxanide | SARS-CoV 3CL Protease | NO | 0.39 |\n", |
||
| 474 | "| 14 | Letermovir | SARS-CoV 3CL Protease | NO | 0.23 |\n", |
||
| 475 | "| 15 | Amantadine | SARS-CoV 3CL Protease | NO | 0.17 |\n", |
||
| 476 | "| 16 | Indinavir | SARS-CoV 3CL Protease | NO | 0.09 |\n", |
||
| 477 | "| 17 | Atazanavir | SARS-CoV 3CL Protease | NO | 0.08 |\n", |
||
| 478 | "| 18 | Didanosine | SARS-CoV 3CL Protease | NO | 0.07 |\n", |
||
| 479 | "| 19 | Tenofovir_disoproxil | SARS-CoV 3CL Protease | NO | 0.06 |\n", |
||
| 480 | "| 20 | Podophyllotoxin | SARS-CoV 3CL Protease | NO | 0.03 |\n", |
||
| 481 | "| 21 | Docosanol | SARS-CoV 3CL Protease | NO | 0.03 |\n", |
||
| 482 | "| 22 | Zanamivir | SARS-CoV 3CL Protease | NO | 0.03 |\n", |
||
| 483 | "| 23 | Peramivir | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 484 | "| 24 | Lopinavir | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 485 | "| 25 | Nelfinavir | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 486 | "| 26 | Bictegravir | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 487 | "| 27 | Imiquimod | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 488 | "| 28 | Nevirapine | SARS-CoV 3CL Protease | NO | 0.01 |\n", |
||
| 489 | "| 29 | Grazoprevir | SARS-CoV 3CL Protease | NO | 0.00 |\n", |
||
| 490 | "| 30 | Foscarnet | SARS-CoV 3CL Protease | NO | 0.00 |\n", |
||
| 491 | "checkout ./save_folder/results_aggregation/repurposing.txt for the whole list\n", |
||
| 492 | "\n" |
||
| 493 | ] |
||
| 494 | }, |
||
| 495 | { |
||
| 496 | "data": { |
||
| 497 | "image/png": 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\n", |
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| 498 | "text/plain": [ |
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| 499 | "<Figure size 432x288 with 1 Axes>" |
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| 500 | ] |
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| 501 | }, |
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| 502 | "metadata": { |
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| 503 | "needs_background": "light" |
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| 504 | }, |
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| 505 | "output_type": "display_data" |
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| 506 | }, |
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| 507 | { |
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| 508 | "data": { |
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| 509 | "image/png": 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\n", |
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| 510 | "text/plain": [ |
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| 511 | "<Figure size 432x288 with 1 Axes>" |
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| 512 | ] |
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| 513 | }, |
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| 514 | "metadata": { |
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| 515 | "needs_background": "light" |
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| 516 | }, |
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| 517 | "output_type": "display_data" |
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| 518 | }, |
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| 519 | { |
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| 520 | "data": { |
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| 521 | "image/png": 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\n", |
||
| 522 | "text/plain": [ |
||
| 523 | "<Figure size 432x288 with 1 Axes>" |
||
| 524 | ] |
||
| 525 | }, |
||
| 526 | "metadata": { |
||
| 527 | "needs_background": "light" |
||
| 528 | }, |
||
| 529 | "output_type": "display_data" |
||
| 530 | } |
||
| 531 | ], |
||
| 532 | "source": [ |
||
| 533 | "oneliner.repurpose(target = target, \n", |
||
| 534 | " target_name = target_name, \n", |
||
| 535 | " train_drug = train_drug,\n", |
||
| 536 | " train_target = train_target,\n", |
||
| 537 | " train_y = train_y,\n", |
||
| 538 | " X_repurpose = X_repurpose,\n", |
||
| 539 | " drug_names = drug_names,\n", |
||
| 540 | " save_dir = './save_folder',\n", |
||
| 541 | " finetune_batch_size = 128,\n", |
||
| 542 | " finetune_LR = 0.001,\n", |
||
| 543 | " finetune_epochs=10,\n", |
||
| 544 | " split='HTS',\n", |
||
| 545 | " convert_y = False,\n", |
||
| 546 | " frac=[0.8,0.1,0.1],\n", |
||
| 547 | " pretrained = True,\n", |
||
| 548 | " pretrained_dir = './save_folder/pretrained_models/DeepPurpose_BindingDB/',\n", |
||
| 549 | " agg = 'max_effect')" |
||
| 550 | ] |
||
| 551 | }, |
||
| 552 | { |
||
| 553 | "cell_type": "code", |
||
| 554 | "execution_count": null, |
||
| 555 | "metadata": {}, |
||
| 556 | "outputs": [], |
||
| 557 | "source": [] |
||
| 558 | } |
||
| 559 | ], |
||
| 560 | "metadata": { |
||
| 561 | "kernelspec": { |
||
| 562 | "display_name": "Python 3", |
||
| 563 | "language": "python", |
||
| 564 | "name": "python3" |
||
| 565 | }, |
||
| 566 | "language_info": { |
||
| 567 | "codemirror_mode": { |
||
| 568 | "name": "ipython", |
||
| 569 | "version": 3 |
||
| 570 | }, |
||
| 571 | "file_extension": ".py", |
||
| 572 | "mimetype": "text/x-python", |
||
| 573 | "name": "python", |
||
| 574 | "nbconvert_exporter": "python", |
||
| 575 | "pygments_lexer": "ipython3", |
||
| 576 | "version": "3.7.7" |
||
| 577 | } |
||
| 578 | }, |
||
| 579 | "nbformat": 4, |
||
| 580 | "nbformat_minor": 4 |
||
| 581 | } |