Inflammatory bowel disease (IBD) model targeting IL6R with tocilizumab.
Publication:
A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.
Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, Li C.
CPT Pharmacometrics Syst Pharmacol 2014; 3: e89
Model description and the original version (sbml).
Download here (sbml).
Download here (sbml).
Download here (.xlsx).