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# Exemplary Ordinary Differential Equation (ODE) models





  
  

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Inflammatory bowel disease (IBD) model targeting IL6R with tocilizumab. 





  
  

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Publication: <br>





  
  

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*A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.* <br >





  
  

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Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, Li C.





  
  

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CPT Pharmacometrics Syst Pharmacol 2014; 3: e89





  
  

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## Original model





  
  

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Model [description](https://www.ebi.ac.uk/biomodels/BIOMD0000000537) and [the original version (sbml)](./Dwivedi_Model537_original.xml).





  
  

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## Model without annotations





  
  

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Download [here (sbml)](./Dwivedi_Model537_empty.xml).





  
  

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## Fully annotated model





  
  

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Download [here (sbml)](./Dwivedi_Model537_annotated.xml).





  
  

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## IDs of annotations





  
  

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Download [here (.xlsx)](./model537_mapping.xlsx).