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<div class="dc:title">Dwivedi2014 - Crohns IL6 Disease model -
Anti-IL6R Antibody</div>
<div class="dc:description">This model is comprised of four models:
<br/>
<ul>
<li>
<a href="http://www.ebi.ac.uk/biomodels-main/BIOMD0000000534">[BIOMD0000000534]</a>
Healthy Volunteer model
<br/></li>
<li>
<a href="http://www.ebi.ac.uk/biomodels-main/BIOMD0000000535">[BIOMD0000000535]</a>
Crohn's Disease - IL-6 Antibody
<br/></li>
<li>
<a href="http://www.ebi.ac.uk/biomodels-main/BIOMD0000000536">[BIOMD0000000536]</a>
Crohn's Disease - sgp130FC</li>
<li>
<a href="http://www.ebi.ac.uk/biomodels-main/BIOMD0000000537">[BIOMD0000000537]</a>
Crohn's Disease - IL-6Ra Antibody
<br/></li>
</ul>Possible avenues for Interleukin-6 (IL-6) inhibition in
treating Crohn's disease are compared here. Each model refers to
separate ligands. The system simulates differential activity of the
ligands on the signalling of IL-6.
<span class="st">This affects Signal Transducer and Activator of
Transcription 3</span> (STAT3) activity on the production of
biomarker C-Reactive Protein (CRP) expression.
<br/>Figures referring to this Crohn's Disease model are 3a, 4d,
4e, 4f and 5b.
<br/></div>
<div class="dc:bibliographicCitation">
<p>This model is described in the article:</p>
<div class="bibo:title">
<a href="http://identifiers.org/pubmed/24402116" title="Access to this publication">A multiscale model of
interleukin-6-mediated immune regulation in Crohn's disease and
its application in drug discovery and development.</a>
</div>
<div class="bibo:authorList">Dwivedi G, Fitz L, Hegen M, Martin
SW, Harrold J, Heatherington A, Li C.</div>
<div class="bibo:Journal">CPT Pharmacometrics Syst Pharmacol
2014; 3: e89</div>
<p>Abstract:</p>
<div class="bibo:abstract">
<p>In this study, we have developed a multiscale systems model
of interleukin (IL)-6-mediated immune regulation in Crohn's
disease, by integrating intracellular signaling with
organ-level dynamics of pharmacological markers underlying the
disease. This model was linked to a general pharmacokinetic
model for therapeutic monoclonal antibodies and used to
comparatively study various biotherapeutic strategies targeting
IL-6-mediated signaling in Crohn's disease. Our work
illustrates techniques to develop mechanistic models of disease
biology to study drug-system interaction. Despite a sparse
training data set, predictions of the model were qualitatively
validated by clinical biomarker data from a pilot trial with
tocilizumab. Model-based analysis suggests that strategies
targeting IL-6, IL-6R?, or the IL-6/sIL-6R? complex are less
effective at suppressing pharmacological markers of Crohn's
than dual targeting the IL-6/sIL-6R? complex in addition to
IL-6 or IL-6R?. The potential value of multiscale system
pharmacology modeling in drug discovery and development is also
discussed.CPT: Pharmacometrics & Systems Pharmacology
(2014) 3, e89; doi:10.1038/psp.2013.64; advance online
publication 8 January 2014.</p>
</div>
</div>
<div class="dc:publisher">
<p>This model is hosted on
<a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a>
and identified by:
<a href="http://identifiers.org/biomodels.db/BIOMD0000000537">BIOMD0000000537</a>.</p>
<p>To cite BioModels Database, please use:
<a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models</a>.</p>
</div>
<div class="dc:license">
<p>To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
<a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0
Public Domain Dedication</a> for more information.</p>
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<ci> mwe8fc1900_f07d_468b_b5c8_15400a583c3d </ci>
</bvar>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci> mw9442cd0e_4d7c_4ba6_a695_f84919bdf569 </ci>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
<ci> mw42054cd7_17af_46da_970c_7f99151906ad </ci>
</apply>
<apply>
<plus/>
<ci> mwe8fc1900_f07d_468b_b5c8_15400a583c3d </ci>
<ci> mw42054cd7_17af_46da_970c_7f99151906ad </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_4" name="Function for reaction_4_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kIL6Decay </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kIL6Decay </ci>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw71d90b81_8211_4039_8807_12a7fe03206c" name="Function for mw71d90b81_8211_4039_8807_12a7fe03206c_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw114aa90f_5f5b_4fe8_9406_361c8489b6a1 </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mw5832a2dc_ee18_44df_aa59_ccb21cb74df2 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mw5832a2dc_ee18_44df_aa59_ccb21cb74df2 </ci>
<ci> mw114aa90f_5f5b_4fe8_9406_361c8489b6a1 </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwba7f4605_8571_439b_b3ab_eb0b43808db8" name="Function for mwba7f4605_8571_439b_b3ab_eb0b43808db8_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<bvar>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_14" name="Function for reaction_14_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRsynth </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<ci> kRsynth </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_11" name="Function for reaction_11_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRint </ci>
</bvar>
<bvar>
<ci> mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRint </ci>
<ci> mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83 </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwf913ea0b_785a_4701_ac91_b18ab5dd5a89" name="Function for mwf913ea0b_785a_4701_ac91_b18ab5dd5a89_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw06241335_b5f2_47ed_bdcc_ef77b68a2b98 </ci>
</bvar>
<bvar>
<ci> mw2c9b0499_3325_4394_8af3_bbf653a944a0 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mw06241335_b5f2_47ed_bdcc_ef77b68a2b98 </ci>
<ci> mw2c9b0499_3325_4394_8af3_bbf653a944a0 </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw50c6744c_e883_4612_8663_e38750cbad1b" name="Function for mw50c6744c_e883_4612_8663_e38750cbad1b_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw1f41474c_c399_4a60_a53a_9926dd092e8d </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<apply>
<divide/>
<ci> mw1f41474c_c399_4a60_a53a_9926dd092e8d </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1" name="Function for mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
</bvar>
<bvar>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
</bvar>
<bvar>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
</bvar>
<bvar>
<ci> mwd31f52cc_04e7_40e0_885f_c7b2d9e62215 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<bvar>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
<ci> mwd31f52cc_04e7_40e0_885f_c7b2d9e62215 </ci>
</apply>
<apply>
<times/>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
</apply>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c" name="Function for mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kgp130Off </ci>
</bvar>
<bvar>
<ci> kgp130On </ci>
</bvar>
<bvar>
<ci> mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3 </ci>
</bvar>
<bvar>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
</bvar>
<bvar>
<ci> mwd65b5b39_dc1b_4e77_a999_67277a880e5e </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kgp130On </ci>
<ci> mwd65b5b39_dc1b_4e77_a999_67277a880e5e </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
</apply>
<apply>
<times/>
<ci> kgp130Off </ci>
<ci> mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3 </ci>
</apply>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_43" name="Function for reaction_43_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw48867e93_f170_44e8_ac7a_185b23e1bf3b </ci>
</bvar>
<bvar>
<ci> mwd36b0261_2480_4cab_9222_2cf8fb0e65dc </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<bvar>
<ci> mwfd291862_195f_4979_94b5_b4e5ae1b7d52 </ci>
</bvar>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci> mwd36b0261_2480_4cab_9222_2cf8fb0e65dc </ci>
<ci> mw48867e93_f170_44e8_ac7a_185b23e1bf3b </ci>
</apply>
<apply>
<plus/>
<ci> mwfd291862_195f_4979_94b5_b4e5ae1b7d52 </ci>
<ci> mw48867e93_f170_44e8_ac7a_185b23e1bf3b </ci>
</apply>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw6db30657_4e56_4c3a_8575_9c67393dde4f" name="Function for mw6db30657_4e56_4c3a_8575_9c67393dde4f_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRsynth </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<ci> kRsynth </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_42" name="Function for reaction_42_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw2b255f94_8018_4b99_bde8_918eeac45446 </ci>
</bvar>
<bvar>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
</bvar>
<bvar>
<ci> mw9442cd0e_4d7c_4ba6_a695_f84919bdf569 </ci>
</bvar>
<bvar>
<ci> mwe8fc1900_f07d_468b_b5c8_15400a583c3d </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci> mw9442cd0e_4d7c_4ba6_a695_f84919bdf569 </ci>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
<ci> mw2b255f94_8018_4b99_bde8_918eeac45446 </ci>
</apply>
<apply>
<plus/>
<ci> mwe8fc1900_f07d_468b_b5c8_15400a583c3d </ci>
<ci> mw2b255f94_8018_4b99_bde8_918eeac45446 </ci>
</apply>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_46" name="Function for reaction_46_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRAct </ci>
</bvar>
<bvar>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRAct </ci>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76" name="Function for mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1 </ci>
</bvar>
<apply>
<divide/>
<ci> mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw1ce0c484_681f_4d85_8ffe_392d0c100cfa" name="Function for mw1ce0c484_681f_4d85_8ffe_392d0c100cfa_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<ci> mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b" name="Function for mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
</bvar>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db" name="Function for mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</bvar>
<bvar>
<ci> mwbcb5a310_9b67_405e_89ec_43d25e8cc93d </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbcb5a310_9b67_405e_89ec_43d25e8cc93d </ci>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwe84cc3ad_af35_43a8_aa6a_9f68a6d68185" name="Function for mwe84cc3ad_af35_43a8_aa6a_9f68a6d68185_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<bvar>
<ci> mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2 </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_12" name="Function for reaction_12_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRint </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRint </ci>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw5e1e306a_63ed_43a8_b79f_b403516e7963" name="Function for mw5e1e306a_63ed_43a8_b79f_b403516e7963_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac </ci>
</bvar>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwa812f08f_1035_42bd_82d2_72d691308f88" name="Function for mwa812f08f_1035_42bd_82d2_72d691308f88_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRLOff </ci>
</bvar>
<bvar>
<ci> kRLOn </ci>
</bvar>
<bvar>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
</bvar>
<bvar>
<ci> mw2e464cf3_a09c_4b7c_9f3c_06720016a48e </ci>
</bvar>
<bvar>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kRLOn </ci>
<ci> mw2e464cf3_a09c_4b7c_9f3c_06720016a48e </ci>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
</apply>
<apply>
<times/>
<ci> kRLOff </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw4a00a3a4_778f_4952_8100_2dc3cc2b7046" name="Function for mw4a00a3a4_778f_4952_8100_2dc3cc2b7046_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRdeg </ci>
</bvar>
<bvar>
<ci> mw80848184_e2dd_47ce_86d7_7a21479342bd </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRdeg </ci>
<ci> mw80848184_e2dd_47ce_86d7_7a21479342bd </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6" name="Function for mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kgp130Off </ci>
</bvar>
<bvar>
<ci> kgp130On </ci>
</bvar>
<bvar>
<ci> mw147d30ec_478e_4090_b496_128a131d29eb </ci>
</bvar>
<bvar>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwab41493c_6349_45f1_a226_3030cfed0e06 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kgp130On </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
<ci> mw147d30ec_478e_4090_b496_128a131d29eb </ci>
</apply>
<apply>
<times/>
<ci> kgp130Off </ci>
<ci> mwab41493c_6349_45f1_a226_3030cfed0e06 </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw6f470e13_f0e4_4294_83d8_59dd5670d10c" name="Function for mw6f470e13_f0e4_4294_83d8_59dd5670d10c_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRdeg </ci>
</bvar>
<bvar>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRdeg </ci>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_2" name="Function for reaction_2_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kgp130Off </ci>
</bvar>
<bvar>
<ci> kgp130On </ci>
</bvar>
<bvar>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mw810ff751_fa4e_4143_bd50_169b3e325e1e </ci>
</bvar>
<bvar>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kgp130On </ci>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</apply>
<apply>
<times/>
<ci> kgp130Off </ci>
<ci> mw810ff751_fa4e_4143_bd50_169b3e325e1e </ci>
</apply>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw30abb016_4300_4f40_a1b3_f865d0a45707" name="Function for mw30abb016_4300_4f40_a1b3_f865d0a45707_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_41" name="Function for reaction_41_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kgp130Off </ci>
</bvar>
<bvar>
<ci> kgp130On </ci>
</bvar>
<bvar>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
</bvar>
<bvar>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
</bvar>
<bvar>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kgp130On </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
</apply>
<apply>
<times/>
<ci> kgp130Off </ci>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
</apply>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_16" name="Function for reaction_16_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRAct </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRAct </ci>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4" name="Function for mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
</bvar>
<bvar>
<ci> mw1667a8e0_9d20_4e59_ba51_596148aba787 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8 </ci>
</bvar>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci> mw1667a8e0_9d20_4e59_ba51_596148aba787 </ci>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
</apply>
<apply>
<plus/>
<ci> mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8 </ci>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mwfeae4233_1272_453f_a97f_70982c445b43" name="Function for mwfeae4233_1272_453f_a97f_70982c445b43_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw9629d028_fcc0_4886_9e4d_36eecdb0381d" name="Function for mw9629d028_fcc0_4886_9e4d_36eecdb0381d_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<bvar>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw432fde6e_59ab_47f0_9fb1_086433a602e3" name="Function for mw432fde6e_59ab_47f0_9fb1_086433a602e3_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab </ci>
</bvar>
<apply>
<divide/>
<ci> mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw6b46c550_674f_4857_b947_d31221cd8dd3" name="Function for mw6b46c550_674f_4857_b947_d31221cd8dd3_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
</bvar>
<bvar>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
</bvar>
<bvar>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
</bvar>
<bvar>
<ci> mw772cbf20_3fc1_4800_ae59_77884f1ae333 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
</apply>
<apply>
<times/>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw772cbf20_3fc1_4800_ae59_77884f1ae333 </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_mw391f3b8e_5649_4851_b2e2_782cb3e015b6" name="Function for mw391f3b8e_5649_4851_b2e2_782cb3e015b6_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRsynth </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<ci> kRsynth </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_45" name="Function for reaction_45_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
</bvar>
<bvar>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</bvar>
<bvar>
<ci> mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a </ci>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
</apply>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_7" name="Function for reaction_7_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRLOff </ci>
</bvar>
<bvar>
<ci> kRLOn </ci>
</bvar>
<bvar>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
</bvar>
<bvar>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
</bvar>
<bvar>
<ci> mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kRLOn </ci>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
</apply>
<apply>
<times/>
<ci> kRLOff </ci>
<ci> mw7d86cc23_a1af_44c3_bdb9_71e9b1bb2a83 </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_6" name="Function for reaction_6_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kgp130Off </ci>
</bvar>
<bvar>
<ci> kgp130On </ci>
</bvar>
<bvar>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
</bvar>
<bvar>
<ci> mw80848184_e2dd_47ce_86d7_7a21479342bd </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<bvar>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kgp130On </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
<ci> mw80848184_e2dd_47ce_86d7_7a21479342bd </ci>
</apply>
<apply>
<times/>
<ci> kgp130Off </ci>
<ci> mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a </ci>
</apply>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_15" name="Function for reaction_15_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRdeg </ci>
</bvar>
<bvar>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
</bvar>
<bvar>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> kRdeg </ci>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
</apply>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Function_for_reaction_1" name="Function for reaction_1_2_3_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> kRLOff </ci>
</bvar>
<bvar>
<ci> kRLOn </ci>
</bvar>
<bvar>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
</bvar>
<bvar>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
</bvar>
<bvar>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</bvar>
<bvar>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> kRLOn </ci>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</apply>
<apply>
<times/>
<ci> kRLOff </ci>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
</apply>
</apply>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</lambda>
</math>
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<species id="mw2c9b0499_3325_4394_8af3_bbf653a944a0" name="IL6" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="0.0093481986616084" boundaryCondition="false" constant="false"/>
<species id="mwd65b5b39_dc1b_4e77_a999_67277a880e5e" name="sgp130" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="5.56973864471412" boundaryCondition="false" constant="false"/>
<species id="mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3" name="sR_IL6_sgp130" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="0.136303909449242" boundaryCondition="false" constant="false"/>
<species id="mwf7796221_1fea_4274_a93e_c00adbf5778c" name="Ab" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="2.1587895876493e-29" boundaryCondition="false" constant="false"/>
<species id="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0" name="Ab_sR" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="2.62059686237767e-26" boundaryCondition="false" constant="false"/>
<species id="mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2" name="Ab_sR_IL6" compartment="mwe9501423_9fb4_494b_b5b6_288f3fcb17b5" initialConcentration="-1.209166949e-28" boundaryCondition="false" constant="false"/>
<species id="mwbc2f5464_81e5_43fd_8b39_f5a2756af72f" name="Ab" compartment="mw8fbcbf3b_47d8_4adc_8ad4_f9fc547d3e87" initialConcentration="1.67920947537896e-29" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="kRLOn" name="kRLOn" value="0.384" constant="true"/>
<parameter id="kRLOff" name="kRLOff" value="1.92" constant="true"/>
<parameter metaid="COPASI5" id="kgp130On" name="kgp130On" value="20.52" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI5">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:31Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="kgp130Off" name="kgp130Off" value="1.026" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">1/hr
Kd = 50 pM
</body>
</notes>
</parameter>
<parameter id="kRAct" name="kRAct" value="155" constant="true"/>
<parameter metaid="COPASI6" id="kRint" name="kRint" value="1.96" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI6">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:33Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="kRsynth" name="kRsynth" value="0.0685" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">nM/hr
Estimated at 115 receptor/cell/hr using the receptor model for HepG2 cells. With HepG2 cell volume of 2.8 pL/cell, this translates to 0.0685 nM/hr. Since this rate in terms of concentration is independent of cell volume, it can be used directly for cells with different volumes but similar receptor dynamics.</body>
</notes>
</parameter>
<parameter id="kRdeg" name="kRintBasal" value="0.1561" constant="true"/>
<parameter id="kIL6Synth" name="ksynthIL6" value="0.0063" constant="true"/>
<parameter id="kIL6Decay" name="kdegIL6" value="34.82" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">1/hr
Estimated from drug PK models</body>
</notes>
</parameter>
<parameter id="kCRPDecay" name="kdegCRP" value="0.36" constant="true"/>
<parameter id="mwfd291862_195f_4979_94b5_b4e5ae1b7d52" name="KmSTATDephos" value="5.34" constant="true"/>
<parameter metaid="COPASI7" id="mwd36b0261_2480_4cab_9222_2cf8fb0e65dc" name="VmSTATDephos" value="0.62" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI7">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T13:02:16Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI8" id="mw1667a8e0_9d20_4e59_ba51_596148aba787" name="VmRDephos" value="0.525" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">18 nM/hr</body>
</notes>
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI8">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T13:02:16Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI9" id="mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8" name="KmRDephos" value="155.3" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI9">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mw9442cd0e_4d7c_4ba6_a695_f84919bdf569" name="kcatSTATPhos" value="145" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">1/hr</body>
</notes>
</parameter>
<parameter id="mwe8fc1900_f07d_468b_b5c8_15400a583c3d" name="KmSTATPhos" value="219" constant="true"/>
<parameter id="mw08950572_81b0_4570_b2e4_b9c3462c1425" name="KmProtSynth" value="10" constant="true"/>
<parameter id="mw92d854a7_8aaf_458e_b5e2_20a63ce9b654" name="VmProtSynth" value="330" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">nM
Commonly used model of protein synthesis:
mRNA: dm/dt = Sm*TF/(C + TF) - Dm*m
Protein: dn/dt = Sn*m - Dn*n
Solving for st. st: n(ss) = (Sn/Dn)*(Sm/Dm)*TF/(C+TF)
VmProtSynth = (Sn/Dn)*(Sm/Dm) = 4875000
KmProtSynth = C = 108
The parameters are obtained from Moya et al. (2010), who estimate these parameters for IL6 signaling.
The actual value used may be different, as it was optimized to fit the data
</body>
</notes>
</parameter>
<parameter id="mw862f1480_c60c_4863_a565_b2c1c77e238e" name="kCRPSecretion" value="0.5" constant="true"/>
<parameter id="mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1" name="ksynthCRP" value="0.42" constant="true"/>
<parameter id="mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab" name="ksynthsR" value="0.1" constant="true"/>
<parameter metaid="COPASI10" id="mw88a75379_f9a1_4acc_baeb_94c32bb736a5" name="kdegsR" value="0.3" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI10">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:30Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mw1f41474c_c399_4a60_a53a_9926dd092e8d" name="ksynthsgp130" value="3.9" constant="true"/>
<parameter id="mwbcb5a310_9b67_405e_89ec_43d25e8cc93d" name="kdegsgp130" value="1" constant="true"/>
<parameter id="mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69" name="ksynthIL6Gut" value="0.036" constant="true"/>
<parameter metaid="COPASI11" id="mw06241335_b5f2_47ed_bdcc_ef77b68a2b98" name="kdegIL6Gut" value="1" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI11">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:28Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI12" id="mwce10678d_8197_408c_ad47_1daec8104cd8" name="kdistTissueToSerum" value="0.8473" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI12">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:31Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb" name="kdistSerumToTissue" value="1.2125" constant="true"/>
<parameter id="mw5832a2dc_ee18_44df_aa59_ccb21cb74df2" name="kRShedding" value="0.0054" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">1/hr
Slow receptor shedding driven by CRP. The parameter has been calculated, along with the basal sR synthesis rate, to get
sR = 1.6, when CRP = 40 (HV); and
sR = 2.8, when CRP = 2000 (CD).</body>
</notes>
</parameter>
<parameter id="mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a" name="kintActiveR" value="0.01" constant="true"/>
<parameter metaid="COPASI13" id="mwa09d6284_843e_404e_abbb_052fbb535197" name="kIL6RBind" value="1000" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI13">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:32:02Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI14" id="mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead" name="kIL6RUnbind" value="2.5" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI14">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T11:24:13Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI15" id="mwdc9e2eb7_c8f4_4026_a8d0_eff8ce1f1aea" name="infusionTime" value="1" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI15">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T11:08:30Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mw640ca705_e089_4c64_a5f4_9562317e8c76" name="kAbSerumToLiver" value="0.0208333333333333" constant="true"/>
<parameter id="mw43ccad8c_cabf_4eaf_90d5_e06ae43be2cb" name="kAbLiverToSerum" value="0.0208333333333333" constant="true"/>
<parameter id="mw9f83bdd3_3aa1_47ff_abd6_54e5ce60704a" name="kAbSerumToGut" value="0.0104166666666667" constant="true"/>
<parameter id="mwa071fdbe_d498_4620_a7a4_940aa31c8161" name="kAbGutToSerum" value="0.0208333333333333" constant="true"/>
<parameter id="mw2c605ff5_50f5_45f2_a70c_53fcd866d14c" name="VSerum" value="2.88" constant="true"/>
<parameter metaid="COPASI16" id="mwc691d0d1_8c1b_4ce4_85c6_1315c42e97b1" name="VLiver" value="2.88" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI16">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-08-01T12:26:51Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mwa8283449_0e21_41a1_baac_ebf697b3555a" name="VGut" value="1.44" constant="true"/>
<parameter metaid="COPASI17" id="mw6729db10_c577_4319_b355_2e3f11c0f942" name="VPeriph" value="0.576" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI17">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T13:02:16Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="mw434adaf5_cef0_4a33_9ad2_a4e49e1fd825" name="QSerumLiver" value="0.06" constant="true"/>
<parameter id="mw6a5e10a9_d442_4dde_8ec3_6a26c9807374" name="QSerumGut" value="0.03" constant="true"/>
<parameter id="mw1366c3b5_e79b_44a7_93cc_ee09d383eabf" name="QSerumPeriph" value="0.001" constant="true"/>
<parameter id="mwf67caf9d_2f4b_4986_abf2_e6090bbb72ce" name="kAbSerumToPeriph" value="0.000347222222222222" constant="true"/>
<parameter id="mw4aea26f6_8860_414c_97f5_40d325196f2e" name="kAbPeriphToSerum" value="0.00173611111111111" constant="true"/>
<parameter metaid="COPASI18" id="mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30" name="kdegAb" value="0.0018" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI18">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:32:07Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI19" id="Dose" name="Dose" value="300" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI19">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-18T11:08:44Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter metaid="COPASI20" id="parameter_1" name="DoseQ2W" value="0" constant="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI20">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-08-01T12:08:30Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
</parameter>
<parameter id="Metabolite_3" name="Initial for CRP" value="221.06367608557">
<annotation>
<initialValue xmlns="http://copasi.org/initialValue" parent="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1" type="InitialConcentration"/>
</annotation>
</parameter>
<parameter id="ModelValue_49" name="Initial for DoseQ2W" value="0">
<annotation>
<initialValue xmlns="http://copasi.org/initialValue" parent="parameter_1" type="InitialValue"/>
</annotation>
</parameter>
<parameter id="ModelValue_48" name="Initial for Dose" value="300">
<annotation>
<initialValue xmlns="http://copasi.org/initialValue" parent="Dose" type="InitialValue"/>
</annotation>
</parameter>
</listOfParameters>
<listOfInitialAssignments>
<initialAssignment symbol="mw640ca705_e089_4c64_a5f4_9562317e8c76">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<ci> mw434adaf5_cef0_4a33_9ad2_a4e49e1fd825 </ci>
<ci> mw2c605ff5_50f5_45f2_a70c_53fcd866d14c </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="mw43ccad8c_cabf_4eaf_90d5_e06ae43be2cb">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<ci> mw434adaf5_cef0_4a33_9ad2_a4e49e1fd825 </ci>
<ci> mwc691d0d1_8c1b_4ce4_85c6_1315c42e97b1 </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="mw9f83bdd3_3aa1_47ff_abd6_54e5ce60704a">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<ci> mw6a5e10a9_d442_4dde_8ec3_6a26c9807374 </ci>
<ci> mw2c605ff5_50f5_45f2_a70c_53fcd866d14c </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="mwa071fdbe_d498_4620_a7a4_940aa31c8161">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<ci> mw6a5e10a9_d442_4dde_8ec3_6a26c9807374 </ci>
<ci> mwa8283449_0e21_41a1_baac_ebf697b3555a </ci>
</apply>
</math>
</initialAssignment>
<initialAssignment symbol="mwf67caf9d_2f4b_4986_abf2_e6090bbb72ce">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
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<reaction id="reaction_13" name="reaction_13" reversible="false">
<listOfReactants>
<speciesReference species="mw0eb6c959_d408_45a0_a450_928b8c5876bb" stoichiometry="1"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_reaction_13 </ci>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<listOfProducts>
<speciesReference species="mw10315fa3_6f13_4618_bda8_a8694bd3c374" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_reaction_14 </ci>
<ci> kRsynth </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_41" name="reaction_41" reversible="true">
<listOfReactants>
<speciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62" stoichiometry="1"/>
<speciesReference species="mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca" stoichiometry="1"/>
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<listOfProducts>
<speciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62"/>
<modifierSpeciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9"/>
<modifierSpeciesReference species="mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_41 </ci>
<ci> kgp130Off </ci>
<ci> kgp130On </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_46" name="reaction_46" reversible="false">
<listOfReactants>
<speciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_46 </ci>
<ci> kRAct </ci>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_42" name="reaction_42" reversible="false">
<listOfReactants>
<speciesReference species="mw2b255f94_8018_4b99_bde8_918eeac45446" stoichiometry="1"/>
<speciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw48867e93_f170_44e8_ac7a_185b23e1bf3b" stoichiometry="1"/>
<speciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw2b255f94_8018_4b99_bde8_918eeac45446"/>
<modifierSpeciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_42 </ci>
<ci> mw2b255f94_8018_4b99_bde8_918eeac45446 </ci>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
<ci> mw9442cd0e_4d7c_4ba6_a695_f84919bdf569 </ci>
<ci> mwe8fc1900_f07d_468b_b5c8_15400a583c3d </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_43" name="reaction_43" reversible="false">
<listOfReactants>
<speciesReference species="mw48867e93_f170_44e8_ac7a_185b23e1bf3b" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw2b255f94_8018_4b99_bde8_918eeac45446" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw48867e93_f170_44e8_ac7a_185b23e1bf3b"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_43 </ci>
<ci> mw48867e93_f170_44e8_ac7a_185b23e1bf3b </ci>
<ci> mwd36b0261_2480_4cab_9222_2cf8fb0e65dc </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwfd291862_195f_4979_94b5_b4e5ae1b7d52 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="reaction_44" name="reaction_44" reversible="false">
<listOfReactants>
<speciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_44 </ci>
<ci> kRint </ci>
<ci> mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="COPASI24" id="reaction_45" name="reaction_45" reversible="false">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI24">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-07-31T13:31:25Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
<listOfReactants>
<speciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_reaction_45 </ci>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwf44f7f27_5bb1_4c7f_8964_560fa5e1743a </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4" name="mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4" reversible="false">
<listOfReactants>
<speciesReference species="mw0eb6c959_d408_45a0_a450_928b8c5876bb" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwd2d9d93a_3bd1_4f17_bac1_baba9ef2d55a" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw0eb6c959_d408_45a0_a450_928b8c5876bb"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mwb675e13a_26c0_4b18_a8c3_0f5a62090ba4 </ci>
<ci> mw0eb6c959_d408_45a0_a450_928b8c5876bb </ci>
<ci> mw1667a8e0_9d20_4e59_ba51_596148aba787 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw64df7c9e_35da_4c7f_be56_c5dabfb060b6" name="mw64df7c9e_35da_4c7f_be56_c5dabfb060b6" reversible="false">
<listOfReactants>
<speciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw824bc3d4_1ac3_4912_9b51_8f14ff1c96b9" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw6cce2109_0e32_4dd9_98ec_41173e8ef07d"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw64df7c9e_35da_4c7f_be56_c5dabfb060b6 </ci>
<ci> mw1667a8e0_9d20_4e59_ba51_596148aba787 </ci>
<ci> mw6cce2109_0e32_4dd9_98ec_41173e8ef07d </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwfcf06900_5f2f_4bb3_bb1f_12023612b8a8 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw391f3b8e_5649_4851_b2e2_782cb3e015b6" name="mw391f3b8e_5649_4851_b2e2_782cb3e015b6" reversible="false">
<listOfProducts>
<speciesReference species="mw80848184_e2dd_47ce_86d7_7a21479342bd" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw391f3b8e_5649_4851_b2e2_782cb3e015b6 </ci>
<ci> kRsynth </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw4a00a3a4_778f_4952_8100_2dc3cc2b7046" name="mw4a00a3a4_778f_4952_8100_2dc3cc2b7046" reversible="false">
<listOfReactants>
<speciesReference species="mw80848184_e2dd_47ce_86d7_7a21479342bd" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw80848184_e2dd_47ce_86d7_7a21479342bd"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw4a00a3a4_778f_4952_8100_2dc3cc2b7046 </ci>
<ci> kRdeg </ci>
<ci> mw80848184_e2dd_47ce_86d7_7a21479342bd </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw6db30657_4e56_4c3a_8575_9c67393dde4f" name="mw6db30657_4e56_4c3a_8575_9c67393dde4f" reversible="false">
<listOfProducts>
<speciesReference species="mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw6db30657_4e56_4c3a_8575_9c67393dde4f </ci>
<ci> kRsynth </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw6f470e13_f0e4_4294_83d8_59dd5670d10c" name="mw6f470e13_f0e4_4294_83d8_59dd5670d10c" reversible="false">
<listOfReactants>
<speciesReference species="mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw6f470e13_f0e4_4294_83d8_59dd5670d10c </ci>
<ci> kRdeg </ci>
<ci> mw8c9107e6_f51d_442d_b2dc_2bfdbb8482ca </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<reaction id="mwfb35eca9_7afc_4ba8_a46c_738cab57eb9f" name="mwfb35eca9_7afc_4ba8_a46c_738cab57eb9f" reversible="true">
<listOfReactants>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
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<listOfProducts>
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<listOfModifiers>
<modifierSpeciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc"/>
<modifierSpeciesReference species="mwd31f52cc_04e7_40e0_885f_c7b2d9e62215"/>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mwd31f52cc_04e7_40e0_885f_c7b2d9e62215 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw61d2af92_6da5_41ce_b90e_aa6f430e6ba1" name="mw61d2af92_6da5_41ce_b90e_aa6f430e6ba1" reversible="true">
<listOfReactants>
<speciesReference species="mwf626e95e_543f_41e4_aad4_c6bf60ab345b" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
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<listOfModifiers>
<modifierSpeciesReference species="mwf626e95e_543f_41e4_aad4_c6bf60ab345b"/>
<modifierSpeciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw2c9b0499_3325_4394_8af3_bbf653a944a0 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw4c099d5c_200f_474e_8ec1_59e9223a8afd" name="mw4c099d5c_200f_474e_8ec1_59e9223a8afd" reversible="true">
<listOfReactants>
<speciesReference species="mwd31f52cc_04e7_40e0_885f_c7b2d9e62215" stoichiometry="1"/>
<speciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0" stoichiometry="1"/>
</listOfReactants>
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<speciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0"/>
<modifierSpeciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62"/>
<modifierSpeciesReference species="mwd31f52cc_04e7_40e0_885f_c7b2d9e62215"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw4c099d5c_200f_474e_8ec1_59e9223a8afd </ci>
<ci> kRLOff </ci>
<ci> kRLOn </ci>
<ci> mw2c9b0499_3325_4394_8af3_bbf653a944a0 </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
<ci> mwd31f52cc_04e7_40e0_885f_c7b2d9e62215 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwbe8567ce_3349_4442_8b12_53cd9bc168e7" name="mwbe8567ce_3349_4442_8b12_53cd9bc168e7" reversible="true">
<listOfReactants>
<speciesReference species="mw03db56ac_8dc6_4931_ae82_fef706d2ee3d" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62" stoichiometry="1"/>
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<listOfModifiers>
<modifierSpeciesReference species="mw03db56ac_8dc6_4931_ae82_fef706d2ee3d"/>
<modifierSpeciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw12a9fa7e_a273_4c1e_b970_ed33f3a9a705" name="mw12a9fa7e_a273_4c1e_b970_ed33f3a9a705" reversible="true">
<listOfReactants>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc"/>
<modifierSpeciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw2e464cf3_a09c_4b7c_9f3c_06720016a48e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw1046000b_e1e8_4f6f_82a1_532d2aa793bb" name="mw1046000b_e1e8_4f6f_82a1_532d2aa793bb" reversible="true">
<listOfReactants>
<speciesReference species="mwf626e95e_543f_41e4_aad4_c6bf60ab345b" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwf626e95e_543f_41e4_aad4_c6bf60ab345b"/>
<modifierSpeciesReference species="mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mwf626e95e_543f_41e4_aad4_c6bf60ab345b </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8e8b65a8_6830_4091_9a40_19645e8fe554" name="mw8e8b65a8_6830_4091_9a40_19645e8fe554" reversible="true">
<listOfReactants>
<speciesReference species="mw03db56ac_8dc6_4931_ae82_fef706d2ee3d" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw03db56ac_8dc6_4931_ae82_fef706d2ee3d"/>
<modifierSpeciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw03db56ac_8dc6_4931_ae82_fef706d2ee3d </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwa812f08f_1035_42bd_82d2_72d691308f88" name="mwa812f08f_1035_42bd_82d2_72d691308f88" reversible="true">
<listOfReactants>
<speciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e" stoichiometry="1"/>
<speciesReference species="mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1"/>
<modifierSpeciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e"/>
<modifierSpeciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mwa812f08f_1035_42bd_82d2_72d691308f88 </ci>
<ci> kRLOff </ci>
<ci> kRLOn </ci>
<ci> mw0adf3eb4_a196_4c48_b10d_4e9e9faaf9e1 </ci>
<ci> mw2e464cf3_a09c_4b7c_9f3c_06720016a48e </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwab0012ac_e5f2_4904_9893_820fd210402e" name="mwab0012ac_e5f2_4904_9893_820fd210402e" reversible="false">
<listOfReactants>
<speciesReference species="mwd5313618_89eb_4c8c_bc82_66f10f966349" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw36ea78c1_ed71_4def_96d3_857a442d7195" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwd5313618_89eb_4c8c_bc82_66f10f966349"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mwab0012ac_e5f2_4904_9893_820fd210402e </ci>
<ci> mw862f1480_c60c_4863_a565_b2c1c77e238e </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwd5313618_89eb_4c8c_bc82_66f10f966349 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwcdc24bd4_d9e4_47fe_8300_d222d853111c" name="mwcdc24bd4_d9e4_47fe_8300_d222d853111c" reversible="true">
<listOfReactants>
<speciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw36ea78c1_ed71_4def_96d3_857a442d7195" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1"/>
<modifierSpeciesReference species="mw36ea78c1_ed71_4def_96d3_857a442d7195"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw114aa90f_5f5b_4fe8_9406_361c8489b6a1 </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw36ea78c1_ed71_4def_96d3_857a442d7195 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76" name="mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76" reversible="false">
<listOfProducts>
<speciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mwff2ebcf1_dcf1_47b9_9cac_7306fc6f7f76 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mw65c85954_5ca0_4df2_9e22_ff2aa3fbe3f1 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw1c5a5ff7_5130_490f_a740_6a744ccf8a94" name="mw1c5a5ff7_5130_490f_a740_6a744ccf8a94" reversible="true">
<listOfReactants>
<speciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwd65b5b39_dc1b_4e77_a999_67277a880e5e" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99"/>
<modifierSpeciesReference species="mwd65b5b39_dc1b_4e77_a999_67277a880e5e"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mwd65b5b39_dc1b_4e77_a999_67277a880e5e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw7b56053c_7256_4703_a8c3_4fd46b2c23d0" name="mw7b56053c_7256_4703_a8c3_4fd46b2c23d0" reversible="true">
<listOfReactants>
<speciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw147d30ec_478e_4090_b496_128a131d29eb" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99"/>
<modifierSpeciesReference species="mw147d30ec_478e_4090_b496_128a131d29eb"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw147d30ec_478e_4090_b496_128a131d29eb </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c" name="mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c" reversible="true">
<listOfReactants>
<speciesReference species="mwd65b5b39_dc1b_4e77_a999_67277a880e5e" stoichiometry="1"/>
<speciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3"/>
<modifierSpeciesReference species="mw7becb5fe_8da8_4285_a821_0d77ad811b62"/>
<modifierSpeciesReference species="mwd65b5b39_dc1b_4e77_a999_67277a880e5e"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw8be158f1_ea81_45bf_80d4_6e31cd83fe6c </ci>
<ci> kgp130Off </ci>
<ci> kgp130On </ci>
<ci> mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3 </ci>
<ci> mw7becb5fe_8da8_4285_a821_0d77ad811b62 </ci>
<ci> mwd65b5b39_dc1b_4e77_a999_67277a880e5e </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6" name="mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6" reversible="true">
<listOfReactants>
<speciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0" stoichiometry="1"/>
<speciesReference species="mw147d30ec_478e_4090_b496_128a131d29eb" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwab41493c_6349_45f1_a226_3030cfed0e06" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw147d30ec_478e_4090_b496_128a131d29eb"/>
<modifierSpeciesReference species="mw4638f126_8cb8_4021_ab41_6ae195743ba0"/>
<modifierSpeciesReference species="mwab41493c_6349_45f1_a226_3030cfed0e06"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mwd77df15b_fed7_41a8_a3d6_b0f6c590c5f6 </ci>
<ci> kgp130Off </ci>
<ci> kgp130On </ci>
<ci> mw147d30ec_478e_4090_b496_128a131d29eb </ci>
<ci> mw4638f126_8cb8_4021_ab41_6ae195743ba0 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwab41493c_6349_45f1_a226_3030cfed0e06 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="COPASI25" id="mw01babcdf_0f03_46b0_81b1_201cc846e361" name="mw01babcdf_0f03_46b0_81b1_201cc846e361" reversible="true">
<annotation>
<copasi:COPASI xmlns:copasi="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI25">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2014-08-01T12:28:24Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</copasi:COPASI>
</annotation>
<listOfReactants>
<speciesReference species="mw810ff751_fa4e_4143_bd50_169b3e325e1e" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw810ff751_fa4e_4143_bd50_169b3e325e1e"/>
<modifierSpeciesReference species="mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw810ff751_fa4e_4143_bd50_169b3e325e1e </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw6335d5d7_c7b0_4bc0_b883_f7ee4915c2c3 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwae5dbb44_7de5_46ab_8c20_ac4f8956b0f0" name="mwae5dbb44_7de5_46ab_8c20_ac4f8956b0f0" reversible="true">
<listOfReactants>
<speciesReference species="mw810ff751_fa4e_4143_bd50_169b3e325e1e" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwab41493c_6349_45f1_a226_3030cfed0e06" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw810ff751_fa4e_4143_bd50_169b3e325e1e"/>
<modifierSpeciesReference species="mwab41493c_6349_45f1_a226_3030cfed0e06"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw810ff751_fa4e_4143_bd50_169b3e325e1e </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mwab41493c_6349_45f1_a226_3030cfed0e06 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw432fde6e_59ab_47f0_9fb1_086433a602e3" name="mw432fde6e_59ab_47f0_9fb1_086433a602e3" reversible="false">
<listOfProducts>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw432fde6e_59ab_47f0_9fb1_086433a602e3 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mwc4c58db7_5535_4590_aaa5_bbc8ed53cdab </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw41c27823_d7ee_4554_9eac_3d5beec8e854" name="mw41c27823_d7ee_4554_9eac_3d5beec8e854" reversible="false">
<listOfReactants>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw41c27823_d7ee_4554_9eac_3d5beec8e854 </ci>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mw88a75379_f9a1_4acc_baeb_94c32bb736a5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw50c6744c_e883_4612_8663_e38750cbad1b" name="mw50c6744c_e883_4612_8663_e38750cbad1b" reversible="false">
<listOfProducts>
<speciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw50c6744c_e883_4612_8663_e38750cbad1b </ci>
<ci> mw1f41474c_c399_4a60_a53a_9926dd092e8d </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db" name="mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db" reversible="false">
<listOfReactants>
<speciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mwbbbce920_e8dd_4320_9386_fc94bfb2fc99"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mwb6a99eb5_ea4c_4733_98dd_1daf5ec6b0db </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mwbbbce920_e8dd_4320_9386_fc94bfb2fc99 </ci>
<ci> mwbcb5a310_9b67_405e_89ec_43d25e8cc93d </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw1ce0c484_681f_4d85_8ffe_392d0c100cfa" name="mw1ce0c484_681f_4d85_8ffe_392d0c100cfa" reversible="false">
<listOfProducts>
<speciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw1ce0c484_681f_4d85_8ffe_392d0c100cfa </ci>
<ci> mwa8d72918_f6c2_4d81_bf3b_fc2b464d5e69 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwf913ea0b_785a_4701_ac91_b18ab5dd5a89" name="mwf913ea0b_785a_4701_ac91_b18ab5dd5a89" reversible="false">
<listOfReactants>
<speciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw2c9b0499_3325_4394_8af3_bbf653a944a0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mwf913ea0b_785a_4701_ac91_b18ab5dd5a89 </ci>
<ci> mw06241335_b5f2_47ed_bdcc_ef77b68a2b98 </ci>
<ci> mw2c9b0499_3325_4394_8af3_bbf653a944a0 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw71d90b81_8211_4039_8807_12a7fe03206c" name="mw71d90b81_8211_4039_8807_12a7fe03206c" reversible="false">
<listOfReactants>
<speciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
<speciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw114aa90f_5f5b_4fe8_9406_361c8489b6a1"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw71d90b81_8211_4039_8807_12a7fe03206c </ci>
<ci> mw114aa90f_5f5b_4fe8_9406_361c8489b6a1 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mw5832a2dc_ee18_44df_aa59_ccb21cb74df2 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwdf4ba845_7271_4ada_b43f_fdac83df3b5c" name="mwdf4ba845_7271_4ada_b43f_fdac83df3b5c" reversible="true">
<listOfReactants>
<speciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwbc2f5464_81e5_43fd_8b39_f5a2756af72f" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded"/>
<modifierSpeciesReference species="mwbc2f5464_81e5_43fd_8b39_f5a2756af72f"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwf67caf9d_2f4b_4986_abf2_e6090bbb72ce </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
<apply>
<times/>
<ci> mw4aea26f6_8860_414c_97f5_40d325196f2e </ci>
<ci> mwbc2f5464_81e5_43fd_8b39_f5a2756af72f </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwb1879013_5fcd_490c_8b01_eaf84df15b9a" name="mwb1879013_5fcd_490c_8b01_eaf84df15b9a" reversible="true">
<listOfReactants>
<speciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded" stoichiometry="1"/>
<speciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7"/>
<modifierSpeciesReference species="mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc"/>
<modifierSpeciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mwb1879013_5fcd_490c_8b01_eaf84df15b9a </ci>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
<ci> mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw30abb016_4300_4f40_a1b3_f865d0a45707" name="mw30abb016_4300_4f40_a1b3_f865d0a45707" reversible="false">
<listOfReactants>
<speciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw30abb016_4300_4f40_a1b3_f865d0a45707 </ci>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwba7f4605_8571_439b_b3ab_eb0b43808db8" name="mwba7f4605_8571_439b_b3ab_eb0b43808db8" reversible="false">
<listOfReactants>
<speciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mwba7f4605_8571_439b_b3ab_eb0b43808db8 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b" name="mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b" reversible="false">
<listOfReactants>
<speciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw8b4e96ed_0bcc_4ad6_b560_366e173a6e6b </ci>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1" name="mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1" reversible="true">
<listOfReactants>
<speciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c" stoichiometry="1"/>
<speciesReference species="mwd31f52cc_04e7_40e0_885f_c7b2d9e62215" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0"/>
<modifierSpeciesReference species="mwd31f52cc_04e7_40e0_885f_c7b2d9e62215"/>
<modifierSpeciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mwa3cb4a9b_d628_4807_8847_bdcd9b40c7f1 </ci>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
<ci> mwd31f52cc_04e7_40e0_885f_c7b2d9e62215 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1" name="mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1" reversible="true">
<listOfReactants>
<speciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d" stoichiometry="1"/>
<speciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw2e464cf3_a09c_4b7c_9f3c_06720016a48e"/>
<modifierSpeciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d"/>
<modifierSpeciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw8fb6c0a7_b05d_4c2a_8866_77eb81f063d1 </ci>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw2e464cf3_a09c_4b7c_9f3c_06720016a48e </ci>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
<ci> mwf405687b_7401_44ec_a0d6_4a2b35c13e8a </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw3e76b10b_5420_4828_8c70_b91b767132d0" name="mw3e76b10b_5420_4828_8c70_b91b767132d0" reversible="false">
<listOfReactants>
<speciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw3e76b10b_5420_4828_8c70_b91b767132d0 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwf405687b_7401_44ec_a0d6_4a2b35c13e8a </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw131e3c9d_e77d_48c0_bdbb_77b2c10aaf3d" name="mw131e3c9d_e77d_48c0_bdbb_77b2c10aaf3d" reversible="true">
<listOfReactants>
<speciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded"/>
<modifierSpeciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw640ca705_e089_4c64_a5f4_9562317e8c76 </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
<apply>
<times/>
<ci> mw43ccad8c_cabf_4eaf_90d5_e06ae43be2cb </ci>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw14940d1f_6a1f_47cb_8170_801ba645f4c1" name="mw14940d1f_6a1f_47cb_8170_801ba645f4c1" reversible="true">
<listOfReactants>
<speciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mwf345ed7a_0622_403c_b816_c8749a2c9ded"/>
<modifierSpeciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw9f83bdd3_3aa1_47ff_abd6_54e5ce60704a </ci>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
</apply>
<apply>
<times/>
<ci> mwa071fdbe_d498_4620_a7a4_940aa31c8161 </ci>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwa2f4d966_ae2c_4ed2_b522_12755f12ff15" name="mwa2f4d966_ae2c_4ed2_b522_12755f12ff15" reversible="true">
<listOfReactants>
<speciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7"/>
<modifierSpeciesReference species="mwf405687b_7401_44ec_a0d6_4a2b35c13e8a"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw640ca705_e089_4c64_a5f4_9562317e8c76 </ci>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
</apply>
<apply>
<times/>
<ci> mw43ccad8c_cabf_4eaf_90d5_e06ae43be2cb </ci>
<ci> mwf405687b_7401_44ec_a0d6_4a2b35c13e8a </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw700e677e_d3b6_4a97_991f_279605a9abeb" name="mw700e677e_d3b6_4a97_991f_279605a9abeb" reversible="true">
<listOfReactants>
<speciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw1da111f2_a036_4392_8512_015005bdcbb7"/>
<modifierSpeciesReference species="mw5d764bb8_5693_4ac8_9557_f65992cc5eb0"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw9f83bdd3_3aa1_47ff_abd6_54e5ce60704a </ci>
<ci> mw1da111f2_a036_4392_8512_015005bdcbb7 </ci>
</apply>
<apply>
<times/>
<ci> mwa071fdbe_d498_4620_a7a4_940aa31c8161 </ci>
<ci> mw5d764bb8_5693_4ac8_9557_f65992cc5eb0 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw2ae288ab_7d03_4a84_a024_c711ad2b77e6" name="mw2ae288ab_7d03_4a84_a024_c711ad2b77e6" reversible="false">
<listOfReactants>
<speciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw2ae288ab_7d03_4a84_a024_c711ad2b77e6 </ci>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw9629d028_fcc0_4886_9e4d_36eecdb0381d" name="mw9629d028_fcc0_4886_9e4d_36eecdb0381d" reversible="false">
<listOfReactants>
<speciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mwf7796221_1fea_4274_a93e_c00adbf5778c"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mw9629d028_fcc0_4886_9e4d_36eecdb0381d </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwf7796221_1fea_4274_a93e_c00adbf5778c </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw6b46c550_674f_4857_b947_d31221cd8dd3" name="mw6b46c550_674f_4857_b947_d31221cd8dd3" reversible="true">
<listOfReactants>
<speciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d" stoichiometry="1"/>
<speciesReference species="mw10315fa3_6f13_4618_bda8_a8694bd3c374" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw772cbf20_3fc1_4800_ae59_77884f1ae333" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw10315fa3_6f13_4618_bda8_a8694bd3c374"/>
<modifierSpeciesReference species="mw3667a5e1_02c9_44a0_acb4_b0431faa822d"/>
<modifierSpeciesReference species="mw772cbf20_3fc1_4800_ae59_77884f1ae333"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw6b46c550_674f_4857_b947_d31221cd8dd3 </ci>
<ci> mw10315fa3_6f13_4618_bda8_a8694bd3c374 </ci>
<ci> mw1c4bc9c3_52ad_4ef7_bf7f_97b0e2101ead </ci>
<ci> mw3667a5e1_02c9_44a0_acb4_b0431faa822d </ci>
<ci> mw772cbf20_3fc1_4800_ae59_77884f1ae333 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwa09d6284_843e_404e_abbb_052fbb535197 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw920e142e_b2c4_42b2_88f4_9f68cc50142e" name="mw920e142e_b2c4_42b2_88f4_9f68cc50142e" reversible="false">
<listOfReactants>
<speciesReference species="mw772cbf20_3fc1_4800_ae59_77884f1ae333" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw772cbf20_3fc1_4800_ae59_77884f1ae333"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mw920e142e_b2c4_42b2_88f4_9f68cc50142e </ci>
<ci> mw772cbf20_3fc1_4800_ae59_77884f1ae333 </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw1b09ae22_e4c7_4830_b566_f263cf4e3f9c" name="mw1b09ae22_e4c7_4830_b566_f263cf4e3f9c" reversible="true">
<listOfReactants>
<speciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac"/>
<modifierSpeciesReference species="mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwf9c93372_1c4e_4988_b8a7_7b9981192b30" name="mwf9c93372_1c4e_4988_b8a7_7b9981192b30" reversible="true">
<listOfReactants>
<speciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac"/>
<modifierSpeciesReference species="mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwc67e1333_079a_4bea_9b4f_0a1b15ddd7bb </ci>
<ci> mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac </ci>
</apply>
<apply>
<times/>
<ci> mwce10678d_8197_408c_ad47_1daec8104cd8 </ci>
<ci> mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw5e1e306a_63ed_43a8_b79f_b403516e7963" name="mw5e1e306a_63ed_43a8_b79f_b403516e7963" reversible="false">
<listOfReactants>
<speciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<apply>
<ci> Function_for_mw5e1e306a_63ed_43a8_b79f_b403516e7963 </ci>
<ci> mw53ffe9e6_beef_45c4_90a5_a79197ed506e </ci>
<ci> mw9947742a_0e4b_4636_9a4b_b6eef2a8f6ac </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwfeae4233_1272_453f_a97f_70982c445b43" name="mwfeae4233_1272_453f_a97f_70982c445b43" reversible="false">
<listOfReactants>
<speciesReference species="mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<apply>
<ci> Function_for_mwfeae4233_1272_453f_a97f_70982c445b43 </ci>
<ci> mw2ba2b802_9f07_4f4d_94c6_24c8de1a95cf </ci>
<ci> mw88ca8d9a_f5cf_41bf_9d9d_fc48f6e1a19e </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwe84cc3ad_af35_43a8_aa6a_9f68a6d68185" name="mwe84cc3ad_af35_43a8_aa6a_9f68a6d68185" reversible="false">
<listOfReactants>
<speciesReference species="mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<apply>
<ci> Function_for_mwe84cc3ad_af35_43a8_aa6a_9f68a6d68185 </ci>
<ci> mwbd1d5bc3_d4b9_4aec_9b86_6f776da20a30 </ci>
<ci> mwe9501423_9fb4_494b_b5b6_288f3fcb17b5 </ci>
<ci> mwedc1bc00_adf7_4144_a1c2_7dc1a9565dc2 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
<listOfEvents>
<event id="Week0" name="Week0" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 0.1 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> ModelValue_49 </ci>
<ci> ModelValue_48 </ci>
</apply>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
<event id="Week4" name="Week4" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 672 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> ModelValue_49 </ci>
<ci> ModelValue_48 </ci>
</apply>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
<event id="Week8" name="Week8" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 1344 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> ModelValue_49 </ci>
<ci> ModelValue_48 </ci>
</apply>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
<event id="Week2" name="Week2" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 336 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<ci> ModelValue_49 </ci>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
<event id="Week6" name="Week6" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 1008 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<ci> ModelValue_49 </ci>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
<event id="Week10" name="Week10" useValuesFromTriggerTime="false">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn> 1680 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="mwf345ed7a_0622_403c_b816_c8749a2c9ded">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> mwf345ed7a_0622_403c_b816_c8749a2c9ded </ci>
<apply>
<times/>
<ci> ModelValue_49 </ci>
<cn> 2.346 </cn>
</apply>
</apply>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
</listOfEvents>
</model>
</sbml>
Datasets
Models
