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b/source/GenomicsAnalysisCode/omics_cfn.yml |
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AWSTemplateFormatVersion: 2010-09-09 |
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Description: Omics Resources |
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Parameters: |
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OmicsResourcePrefix: |
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Type: String |
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Default: omics-cfn |
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OmicsResourcesS3Bucket: |
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Type: String |
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OmicsDataS3Bucket: |
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Type: String |
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OmicsReferenceS3Key: |
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Type: String |
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Default: references/hg38/Homo_sapiens_assembly38.fasta |
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OmicsReferenceName: |
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Type: String |
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Default: hg38 |
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ClinvarS3Key: |
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Type: String |
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Default: annotation/vcf/clinvar/clinvar.vcf.gz |
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SampleVcfS3Key: |
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Type: String |
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Default: variants/vcf/variants.vcf.gz |
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OneKgVcfS3Key: |
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Type: String |
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Default: variants/1kg/ALL.chr22.shapeit2_integrated_snvindels_v2a_27022019.GRCh38.phased.filtNA.vcf.gz |
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OmicsAnnotationStoreName: |
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Type: String |
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Default: omicsannotationstore |
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OmicsVariantStoreName: |
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Type: String |
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Default: omicsvariantstore |
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AnnotationStoreFormat: |
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Type: String |
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Default: 'VCF' |
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Resources: |
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# OMICS CREATE REFERENCE STORE |
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OmicsReferenceStore: |
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Type: Custom::OmicsReferenceStore |
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DependsOn: |
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- OmicsReferenceStoreLambda |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsReferenceStoreLambda.Arn} |
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ReferenceStoreName: !Sub ${OmicsResourcePrefix}-reference-store |
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OmicsReferenceStoreLambda: |
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Type: AWS::Lambda::Function |
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DependsOn: |
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- OmicsReferenceStoreLambdaRole |
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Properties: |
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Handler: create_reference_store_lambda.handler |
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Runtime: python3.9 |
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FunctionName: !Sub ${OmicsResourcePrefix}-create-reference-store |
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Code: |
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S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
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S3Key: artifacts/create_reference_store_lambda.zip |
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Role: !Sub ${OmicsReferenceStoreLambdaRole.Arn} |
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Timeout: 60 |
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OmicsReferenceStoreLambdaRole: |
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Type: AWS::IAM::Role |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- lambda.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: CreateReferenceStorePolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- logs:CreateLogGroup |
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- logs:CreateLogStream |
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- logs:PutLogEvents |
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Resource: |
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- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
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- Effect: Allow |
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Action: |
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- omics:* |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- lambda:AddPermission |
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- lambda:RemovePermission |
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- events:PutRule |
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- events:DeleteRule |
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- events:PutTargets |
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- events:RemoveTargets |
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Resource: '*' |
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# OMICS IMPORT REFERENCE |
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OmicsImportReference: |
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Type: Custom::OmicsImportReference |
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DependsOn: |
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- OmicsReferenceStore |
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- OmicsImportReferenceLambda |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsImportReferenceLambda.Arn} |
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ReferenceStoreId: !Sub ${OmicsReferenceStore.ReferenceStoreId} |
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ReferenceName: !Sub ${OmicsReferenceName} |
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OmicsImportReferenceRoleArn: !Sub ${OmicsImportReferenceJobRole.Arn} |
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ReferenceSourceS3Uri: !Sub s3://${OmicsDataS3Bucket}/${OmicsReferenceS3Key} |
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OmicsImportReferenceLambda: |
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Type: AWS::Lambda::Function |
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DependsOn: |
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- OmicsImportReferenceLambdaRole |
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- OmicsImportReferenceJobRole |
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Properties: |
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Handler: import_reference_lambda.handler |
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Runtime: python3.9 |
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FunctionName: !Sub ${OmicsResourcePrefix}-import-reference |
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Code: |
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S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
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S3Key: artifacts/import_reference_lambda.zip |
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Role: !Sub ${OmicsImportReferenceLambdaRole.Arn} |
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Timeout: 60 |
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OmicsImportReferenceLambdaRole: |
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Type: AWS::IAM::Role |
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DependsOn: |
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- OmicsImportReferenceJobRole |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- lambda.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: ImportReferencePolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- logs:CreateLogGroup |
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- logs:CreateLogStream |
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- logs:PutLogEvents |
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Resource: |
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- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
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- Effect: Allow |
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Action: |
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- omics:* |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- lambda:AddPermission |
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- lambda:RemovePermission |
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- events:PutRule |
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- events:DeleteRule |
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- events:PutTargets |
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- events:RemoveTargets |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- iam:GetRole |
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- iam:PassRole |
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Resource: !Sub ${OmicsImportReferenceJobRole.Arn} |
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OmicsImportReferenceJobRole: |
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Type: AWS::IAM::Role |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- omics.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: ImportReferenceJobRolePolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- s3:GetObject |
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- s3:GetBucketLocation |
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- s3:ListBucket |
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Resource: |
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- !Sub arn:aws:s3:::${OmicsDataS3Bucket} |
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- !Sub arn:aws:s3:::${OmicsDataS3Bucket}/${OmicsReferenceS3Key} |
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# OMICS CREATE VARIANT STORE |
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OmicsVariantStore: |
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Type: Custom::OmicsVariantStore |
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DependsOn: |
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- OmicsVariantStoreLambda |
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- OmicsImportReference |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsVariantStoreLambda.Arn} |
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VariantStoreName: !Sub ${OmicsVariantStoreName} |
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ReferenceArn: !Sub ${OmicsImportReference.Arn} |
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OmicsVariantStoreLambda: |
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Type: AWS::Lambda::Function |
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DependsOn: |
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- OmicsVariantStoreLambdaRole |
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Properties: |
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Handler: create_variant_store_lambda.handler |
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Runtime: python3.9 |
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FunctionName: !Sub ${OmicsResourcePrefix}-create-variant-store |
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Code: |
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S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
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S3Key: artifacts/create_variant_store_lambda.zip |
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Role: !Sub ${OmicsVariantStoreLambdaRole.Arn} |
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Timeout: 60 |
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OmicsVariantStoreLambdaRole: |
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Type: AWS::IAM::Role |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- lambda.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: CreateVariantStorePolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- logs:CreateLogGroup |
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- logs:CreateLogStream |
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- logs:PutLogEvents |
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Resource: |
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- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
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- Effect: Allow |
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Action: |
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- omics:* |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- lambda:AddPermission |
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- lambda:RemovePermission |
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- events:PutRule |
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- events:DeleteRule |
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- events:PutTargets |
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- events:RemoveTargets |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- ram:GetResourceShareInvitations |
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- ram:AcceptResourceShareInvitation |
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Resource: '*' |
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# OMICS IMPORT VARIANT (sample and 1kg) JOB |
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OmicsImportVariantOneKg: |
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Type: Custom::OmicsImportVariantOneKg |
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DependsOn: |
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- OmicsVariantStore |
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- OmicsImportVariantLambda |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsImportVariantLambda.Arn} |
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VariantStoreName: !Sub ${OmicsVariantStoreName} |
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OmicsImportVariantRoleArn: !Sub ${OmicsImportVariantJobRole.Arn} |
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VcfS3Uri: !Sub s3://${OmicsDataS3Bucket}/${OneKgVcfS3Key} |
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OmicsImportVariantSampleVcf: |
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Type: Custom::OmicsImportVariantSampleVcf |
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DependsOn: |
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- OmicsVariantStore |
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- OmicsImportVariantLambda |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsImportVariantLambda.Arn} |
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VariantStoreName: !Sub ${OmicsVariantStoreName} |
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OmicsImportVariantRoleArn: !Sub ${OmicsImportVariantJobRole.Arn} |
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VcfS3Uri: !Sub s3://${OmicsDataS3Bucket}/${SampleVcfS3Key} |
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OmicsImportVariantLambda: |
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Type: AWS::Lambda::Function |
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DependsOn: |
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- OmicsImportVariantLambdaRole |
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Properties: |
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Handler: import_variant_lambda.handler |
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Runtime: python3.9 |
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FunctionName: !Sub ${OmicsResourcePrefix}-import-variant |
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Code: |
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S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
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S3Key: artifacts/import_variant_lambda.zip |
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Role: !Sub ${OmicsImportVariantLambdaRole.Arn} |
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Timeout: 60 |
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OmicsImportVariantLambdaRole: |
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Type: AWS::IAM::Role |
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DependsOn: |
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- OmicsImportVariantJobRole |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- lambda.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: ImportVariantPolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- logs:CreateLogGroup |
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- logs:CreateLogStream |
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- logs:PutLogEvents |
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Resource: |
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- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
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- Effect: Allow |
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Action: |
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- omics:* |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- lambda:AddPermission |
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- lambda:RemovePermission |
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- events:PutRule |
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- events:DeleteRule |
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- events:PutTargets |
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- events:RemoveTargets |
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Resource: '*' |
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- Effect: Allow |
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Action: |
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- iam:GetRole |
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- iam:PassRole |
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Resource: !Sub ${OmicsImportVariantJobRole.Arn} |
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353 |
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OmicsImportVariantJobRole: |
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Type: AWS::IAM::Role |
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Properties: |
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AssumeRolePolicyDocument: |
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Version: 2012-10-17 |
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Statement: |
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- Action: |
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- sts:AssumeRole |
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Effect: Allow |
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Principal: |
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Service: |
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- omics.amazonaws.com |
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Path: / |
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Policies: |
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- PolicyName: OmicsImportVariantJobRolePolicy |
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PolicyDocument: |
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Statement: |
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- Effect: Allow |
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Action: |
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- s3:GetObject |
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- s3:GetBucketLocation |
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- s3:ListBucket |
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Resource: |
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- !Sub arn:aws:s3:::${OmicsDataS3Bucket} |
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- !Sub arn:aws:s3:::${OmicsDataS3Bucket}/${SampleVcfS3Key} |
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- !Sub arn:aws:s3:::${OmicsDataS3Bucket}/${OneKgVcfS3Key} |
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- Effect: Allow |
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Action: |
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- omics:ListReferences |
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- omics:GetReference |
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- omics:GetReferenceMetadata |
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Resource: '*' |
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386 |
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387 |
# OMICS CREATE ANNOTATION STORE |
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388 |
OmicsAnnotationStore: |
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Type: Custom::OmicsAnnotationStore |
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390 |
DependsOn: |
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391 |
- OmicsAnnotationStoreLambda |
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- OmicsImportReference |
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Version: 1.0 |
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Properties: |
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ServiceToken: !Sub ${OmicsAnnotationStoreLambda.Arn} |
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AnnotationStoreName: !Sub ${OmicsAnnotationStoreName} |
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ReferenceArn: !Sub ${OmicsImportReference.Arn} |
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AnnotationStoreFormat: !Sub ${AnnotationStoreFormat} |
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399 |
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OmicsAnnotationStoreLambda: |
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Type: AWS::Lambda::Function |
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DependsOn: |
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- OmicsAnnotationStoreLambdaRole |
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Properties: |
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Handler: create_annotation_store_lambda.handler |
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Runtime: python3.9 |
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FunctionName: !Sub ${OmicsResourcePrefix}-create-annotation-store-v2 |
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Code: |
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S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
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S3Key: artifacts/create_annotation_store_lambda.zip |
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411 |
Role: !Sub ${OmicsAnnotationStoreLambdaRole.Arn} |
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412 |
Timeout: 60 |
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413 |
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414 |
OmicsAnnotationStoreLambdaRole: |
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415 |
Type: AWS::IAM::Role |
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416 |
Properties: |
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417 |
AssumeRolePolicyDocument: |
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418 |
Version: 2012-10-17 |
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419 |
Statement: |
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420 |
- Action: |
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421 |
- sts:AssumeRole |
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422 |
Effect: Allow |
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|
423 |
Principal: |
|
|
424 |
Service: |
|
|
425 |
- lambda.amazonaws.com |
|
|
426 |
Path: / |
|
|
427 |
Policies: |
|
|
428 |
- PolicyName: CreateAnnotationPolicy |
|
|
429 |
PolicyDocument: |
|
|
430 |
Statement: |
|
|
431 |
- Effect: Allow |
|
|
432 |
Action: |
|
|
433 |
- logs:CreateLogGroup |
|
|
434 |
- logs:CreateLogStream |
|
|
435 |
- logs:PutLogEvents |
|
|
436 |
Resource: |
|
|
437 |
- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
|
|
438 |
- Effect: Allow |
|
|
439 |
Action: |
|
|
440 |
- omics:* |
|
|
441 |
Resource: '*' |
|
|
442 |
- Effect: Allow |
|
|
443 |
Action: |
|
|
444 |
- lambda:AddPermission |
|
|
445 |
- lambda:RemovePermission |
|
|
446 |
- events:PutRule |
|
|
447 |
- events:DeleteRule |
|
|
448 |
- events:PutTargets |
|
|
449 |
- events:RemoveTargets |
|
|
450 |
Resource: '*' |
|
|
451 |
- Effect: Allow |
|
|
452 |
Action: |
|
|
453 |
- ram:GetResourceShareInvitations |
|
|
454 |
- ram:AcceptResourceShareInvitation |
|
|
455 |
Resource: '*' |
|
|
456 |
|
|
|
457 |
# OMICS CREATE IMPORT ANNOTATION JOB |
|
|
458 |
OmicsImportAnnotation: |
|
|
459 |
Type: Custom::OmicsImportAnnotation |
|
|
460 |
DependsOn: |
|
|
461 |
- OmicsAnnotationStore |
|
|
462 |
- OmicsImportAnnotationLambda |
|
|
463 |
Version: 1.0 |
|
|
464 |
Properties: |
|
|
465 |
ServiceToken: !Sub ${OmicsImportAnnotationLambda.Arn} |
|
|
466 |
AnnotationStoreName: !Sub ${OmicsAnnotationStoreName} |
|
|
467 |
OmicsImportAnnotationRoleArn: !Sub ${OmicsImportAnnotationJobRole.Arn} |
|
|
468 |
AnnotationSourceS3Uri: !Sub s3://${OmicsDataS3Bucket}/${ClinvarS3Key} |
|
|
469 |
|
|
|
470 |
OmicsImportAnnotationLambda: |
|
|
471 |
Type: AWS::Lambda::Function |
|
|
472 |
DependsOn: |
|
|
473 |
- OmicsImportAnnotationLambdaRole |
|
|
474 |
Properties: |
|
|
475 |
Handler: import_annotation_lambda.handler |
|
|
476 |
Runtime: python3.9 |
|
|
477 |
FunctionName: !Sub ${OmicsResourcePrefix}-import-annotation |
|
|
478 |
Code: |
|
|
479 |
S3Bucket: !Sub ${OmicsResourcesS3Bucket} |
|
|
480 |
S3Key: artifacts/import_annotation_lambda.zip |
|
|
481 |
Role: !Sub ${OmicsImportAnnotationLambdaRole.Arn} |
|
|
482 |
Timeout: 60 |
|
|
483 |
|
|
|
484 |
OmicsImportAnnotationLambdaRole: |
|
|
485 |
Type: AWS::IAM::Role |
|
|
486 |
DependsOn: |
|
|
487 |
- OmicsImportAnnotationJobRole |
|
|
488 |
Properties: |
|
|
489 |
AssumeRolePolicyDocument: |
|
|
490 |
Version: 2012-10-17 |
|
|
491 |
Statement: |
|
|
492 |
- Action: |
|
|
493 |
- sts:AssumeRole |
|
|
494 |
Effect: Allow |
|
|
495 |
Principal: |
|
|
496 |
Service: |
|
|
497 |
- lambda.amazonaws.com |
|
|
498 |
Path: / |
|
|
499 |
Policies: |
|
|
500 |
- PolicyName: ImportAnnotationPolicy |
|
|
501 |
PolicyDocument: |
|
|
502 |
Statement: |
|
|
503 |
- Effect: Allow |
|
|
504 |
Action: |
|
|
505 |
- logs:CreateLogGroup |
|
|
506 |
- logs:CreateLogStream |
|
|
507 |
- logs:PutLogEvents |
|
|
508 |
Resource: |
|
|
509 |
- !Sub arn:aws:logs:${AWS::Region}:${AWS::AccountId}:log-group:/aws/lambda/* |
|
|
510 |
- Effect: Allow |
|
|
511 |
Action: |
|
|
512 |
- omics:* |
|
|
513 |
Resource: '*' |
|
|
514 |
- Effect: Allow |
|
|
515 |
Action: |
|
|
516 |
- lambda:AddPermission |
|
|
517 |
- lambda:RemovePermission |
|
|
518 |
- events:PutRule |
|
|
519 |
- events:DeleteRule |
|
|
520 |
- events:PutTargets |
|
|
521 |
- events:RemoveTargets |
|
|
522 |
Resource: '*' |
|
|
523 |
- Effect: Allow |
|
|
524 |
Action: |
|
|
525 |
- iam:GetRole |
|
|
526 |
- iam:PassRole |
|
|
527 |
Resource: !Sub ${OmicsImportAnnotationJobRole.Arn} |
|
|
528 |
|
|
|
529 |
OmicsImportAnnotationJobRole: |
|
|
530 |
Type: AWS::IAM::Role |
|
|
531 |
Properties: |
|
|
532 |
AssumeRolePolicyDocument: |
|
|
533 |
Version: 2012-10-17 |
|
|
534 |
Statement: |
|
|
535 |
- Action: |
|
|
536 |
- sts:AssumeRole |
|
|
537 |
Effect: Allow |
|
|
538 |
Principal: |
|
|
539 |
Service: |
|
|
540 |
- omics.amazonaws.com |
|
|
541 |
Path: / |
|
|
542 |
Policies: |
|
|
543 |
- PolicyName: ImportAnnotationJobRolePolicy |
|
|
544 |
PolicyDocument: |
|
|
545 |
Statement: |
|
|
546 |
- Effect: Allow |
|
|
547 |
Action: |
|
|
548 |
- s3:GetObject |
|
|
549 |
- s3:GetBucketLocation |
|
|
550 |
- s3:ListBucket |
|
|
551 |
Resource: |
|
|
552 |
- !Sub arn:aws:s3:::${OmicsDataS3Bucket} |
|
|
553 |
- !Sub arn:aws:s3:::${OmicsDataS3Bucket}/${ClinvarS3Key} |
|
|
554 |
- Effect: Allow |
|
|
555 |
Action: |
|
|
556 |
- omics:ListReferences |
|
|
557 |
- omics:GetReference |
|
|
558 |
- omics:GetReferenceMetadata |
|
|
559 |
Resource: '*' |