{"longTitle":"Pediatric diffuse intrinsic pontine gliomas copy number (Puget 2012)","cohort":"Pediatric diffuse intrinsic pontine gliomas (Puget 2012)","url":"http://www.ncbi.nlm.nih.gov/pubmed/22389665","probeMap":"probeMap/hugo_gencode_good_hg19_V24lift37_probemap","dataSubType":"copy number","citation":"PLoS One. 2012; 7(2): e30313.","label":"Treehouse - DIPG copy number (Puget, Philippe)","articletitle":"Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.","tags":["Childhood","pediatrics","neural","central nervous system","cancer"],"anatomical_origin":["Brainstem"],"name":"DIPG_Puget/cgh","dataproducer":"Puget S et al","wrangling_procedure":"Genes by samples data obtained from Chris Jones, process into UCSC cgData repository.","sample_type":["tumor"],"type":"genomicMatrix","version":"2013-08-08","primary_disease":"pediatric diffuse intrinsic pontine gliomas","pmid":22389665,"description":"Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universally fatal. The dataset is part of an integrated molecular profiling of a large series of samples of pediatric DIPG. Two distinct subgroups of DIPG were identified. The first subgroup displayed mesenchymal and pro-angiogenic characteristics, with stem cell marker enrichment consistent with the possibility to grow tumor stem cells from these biopsies. The other subgroup displayed oligodendroglial features, and appeared largely driven by PDGFRA, in particular through amplification and/or novel missense mutations in the extracellular domain. Patients in this later group had a significantly worse outcome."}

Pediatric diffuse intrinsic pontine gliomas copy number (Puget 2012)

{"cohort":"Pediatric diffuse intrinsic pontine gliomas (Puget 2012)","dataSubType":"phenotype","label":"Phenotypes","tags":["cancer"],"name":"DIPG_Puget/DIPG_clinicalMatrix","wrangling_procedure":"Clinical data obtained from Chris Jones, survival data curated at UCSC.","clinicalfeature":"DIPG_Puget/DIPG_clinicalFeature","type":"clinicalMatrix","version":"2013-08-08"}