{"longTitle":"Pediatric diffuse intrinsic pontine gliomas gene expression (Puget 2012)","cohort":"Pediatric diffuse intrinsic pontine gliomas (Puget 2012)","url":"http://www.ncbi.nlm.nih.gov/pubmed/22389665","probeMap":"probeMap/hugo_gencode_good_hg19_V24lift37_probemap","dataSubType":"gene expression","citation":"PLoS One. 2012; 7(2): e30313.","label":"Treehouse - DIPG expression (Puget, Philippe)","articletitle":"Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.","tags":["cancer"],"anatomical_origin":["Brainstem"],"name":"DIPG_Puget/expression","dataproducer":"Puget S et al","wrangling_procedure":"Genes by samples data obtained from Chris Jones, process into UCSC cgData repository.","sample_type":["tumor"],"type":"genomicMatrix","version":"2013-08-08","gdata_tags":["transcription","mRNA"],"primary_disease":"pediatric diffuse intrinsic pontine gliomas","pmid":22389665,"description":"Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universally fatal. The dataset is part of an integrated molecular profiling of a large series of samples of pediatric DIPG. Two distinct subgroups of DIPG were identified. The first subgroup displayed mesenchymal and pro-angiogenic characteristics, with stem cell marker enrichment consistent with the possibility to grow tumor stem cells from these biopsies. The other subgroup displayed oligodendroglial features, and appeared largely driven by PDGFRA, in particular through amplification and/or novel missense mutations in the extracellular domain. Patients in this later group had a significantly worse outcome."}

Pediatric diffuse intrinsic pontine gliomas gene expression (Puget 2012)

{"longTitle":"Pediatric Tumor Affymetrix Gene Expression","cohort":"Pediatric tumor (Khan)","url":"http://pob.abcc.ncifcrf.gov/cgi-bin/JK","probeMap":"probeMap/affyU133_ucscGenomeBrowser_hg18.probeMap","dataSubType":"gene expression","label":"Treehouse - Pediatric tumor expression (Khan)","tags":["cancer"],"anatomical_origin":["Brian","Blood","liver","bone","soft tissue"],"name":"Khan_pediatric/expression","dataproducer":"Javed Khan group","wrangling_procedure":"Download log2 ratios from dataset called Pediatric Tumor Affymetrix Database - New","sample_type":["tumor"],"type":"genomicMatrix","version":"2013-09-27","gdata_tags":["transcription","mRNA"],"primary_disease":"pediatric cancer","colnormalization":true,"description":"\"Pediatric Tumor Affymetrix Database - New\" from Oncogenomics database developed by Javed Khan group.<br><br>"}