Datasets
Models
Downloads: 1
| # | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GO:0030198 | GO:0030198 | extracellular matrix organization | 74/700 | 314/18614 | 3.38080934460631e-38 | 1.02993218786389e-34 | 7.48604372386882e-35 | COL16A1/COL8A2/CTSK/OLFML2B/DPT/FMOD/TGFB2/AGT/EMILIN1/CYP1B1/FAP/COL3A1/COL5A2/COL8A1/ABI3BP/CCDC80/PTX3/PDGFRA/EGFLAM/LOX/TGFBI/ADAMTS2/FOXF2/FOXC1/ADTRP/COL12A1/IL6/AEBP1/ELN/COL1A2/CAV2/CAV1/CSGALNACT1/BMP1/LOXL2/SULF1/HAS2/ADAMTSL1/B4GALT1/ECM2/COL15A1/ENG/COL5A1/LOXL4/KAZALD1/CREB3L1/EFEMP2/MMP8/MMP1/MMP3/LUM/NTN4/POSTN/RGCC/GAS6/MMP14/NID2/FLRT2/FBLN5/GREM1/ANXA2/LOXL1/MMP2/FOXC2/ZNF469/MFAP4/FKBP10/COL1A1/CST3/COL5A3/TGFB1/ADAMTS1/ADAMTS5/RUNX1 | 74 |
| 2 | GO:0043062 | GO:0043062 | extracellular structure organization | 74/700 | 315/18614 | 4.27003394636769e-38 | 1.02993218786389e-34 | 7.48604372386882e-35 | COL16A1/COL8A2/CTSK/OLFML2B/DPT/FMOD/TGFB2/AGT/EMILIN1/CYP1B1/FAP/COL3A1/COL5A2/COL8A1/ABI3BP/CCDC80/PTX3/PDGFRA/EGFLAM/LOX/TGFBI/ADAMTS2/FOXF2/FOXC1/ADTRP/COL12A1/IL6/AEBP1/ELN/COL1A2/CAV2/CAV1/CSGALNACT1/BMP1/LOXL2/SULF1/HAS2/ADAMTSL1/B4GALT1/ECM2/COL15A1/ENG/COL5A1/LOXL4/KAZALD1/CREB3L1/EFEMP2/MMP8/MMP1/MMP3/LUM/NTN4/POSTN/RGCC/GAS6/MMP14/NID2/FLRT2/FBLN5/GREM1/ANXA2/LOXL1/MMP2/FOXC2/ZNF469/MFAP4/FKBP10/COL1A1/CST3/COL5A3/TGFB1/ADAMTS1/ADAMTS5/RUNX1 | 74 |
| 3 | GO:0045229 | GO:0045229 | external encapsulating structure organization | 74/700 | 317/18614 | 6.79185217760146e-38 | 1.09212983015832e-34 | 7.93812617669841e-35 | COL16A1/COL8A2/CTSK/OLFML2B/DPT/FMOD/TGFB2/AGT/EMILIN1/CYP1B1/FAP/COL3A1/COL5A2/COL8A1/ABI3BP/CCDC80/PTX3/PDGFRA/EGFLAM/LOX/TGFBI/ADAMTS2/FOXF2/FOXC1/ADTRP/COL12A1/IL6/AEBP1/ELN/COL1A2/CAV2/CAV1/CSGALNACT1/BMP1/LOXL2/SULF1/HAS2/ADAMTSL1/B4GALT1/ECM2/COL15A1/ENG/COL5A1/LOXL4/KAZALD1/CREB3L1/EFEMP2/MMP8/MMP1/MMP3/LUM/NTN4/POSTN/RGCC/GAS6/MMP14/NID2/FLRT2/FBLN5/GREM1/ANXA2/LOXL1/MMP2/FOXC2/ZNF469/MFAP4/FKBP10/COL1A1/CST3/COL5A3/TGFB1/ADAMTS1/ADAMTS5/RUNX1 | 74 |
| 4 | GO:0001503 | GO:0001503 | ossification | 65/700 | 429/18614 | 4.12868851851166e-22 | 4.97919835332507e-19 | 3.61912143556904e-19 | CSF1/ECM1/CTSK/PTGS2/CRIM1/FHL2/TNFAIP6/COL5A2/IGFBP5/TWIST2/PPARG/WNT5A/SGMS2/HAND2/VEGFC/ANKH/PTGER4/IL6ST/LOX/FBN2/FOXC1/SCUBE3/RUNX2/TWIST1/IL6/IGFBP3/HGF/FZD1/COL1A2/CSGALNACT1/BMP1/CEBPD/SNAI2/PENK/OSR2/CTHRC1/ASPN/TNC/DKK1/SRGN/KAZALD1/IGF2/CREB3L1/LTBP3/MGP/PTHLH/VDR/TMEM119/MMP14/GREM1/ITGA11/SEMA7A/MMP2/CDH11/FOXC2/COL1A1/MRC2/GDF5/ZHX3/FSTL3/JUNB/CLEC11A/WNT7B/MAPK11/COL6A1 | 65 |
| 5 | GO:0030199 | GO:0030199 | collagen fibril organization | 26/700 | 64/18614 | 8.97224818769953e-21 | 8.15505988751134e-18 | 5.92749072298601e-18 | DPT/FMOD/TGFB2/EMILIN1/CYP1B1/COL3A1/COL5A2/LOX/ADAMTS2/FOXC1/COL12A1/AEBP1/COL1A2/BMP1/LOXL2/COL5A1/LOXL4/EFEMP2/LUM/GREM1/ANXA2/LOXL1/FOXC2/FKBP10/COL1A1/COL5A3 | 26 |
| 6 | GO:0061448 | GO:0061448 | connective tissue development | 50/700 | 275/18614 | 1.0143109312825e-20 | 8.15505988751134e-18 | 5.92749072298601e-18 | CSF1/ECM1/CTSK/PRRX1/EFEMP1/HOXD3/COL3A1/PPARG/RARB/TGFBR2/WNT5A/MSX1/HAND2/FOXD1/LOX/PITX1/TGFBI/PDGFRB/RUNX2/SCIN/HOXA3/HOXA5/HOXA11/TIMP1/BGN/CSGALNACT1/BMP1/LOXL2/SNAI2/SULF1/GDF6/OSR2/OGN/COL5A1/ZEB1/ARID5B/ACTA2/CD44/LTBP3/WNT5B/MGP/PTHLH/ACVRL1/GREM1/FOXC2/HOXB3/COL1A1/GDF5/TGFB1/WNT7B | 50 |
| 7 | GO:0032963 | GO:0032963 | collagen metabolic process | 32/700 | 108/18614 | 2.30151946911367e-20 | 1.58607570271491e-17 | 1.15283629347634e-17 | CTSK/EMILIN1/FAP/MIR145/PDGFRB/ADAMTS2/TRAM2/IL6/INHBA/COL1A2/PCOLCE/MIR29A/CTSB/CTSL/ENG/COL5A1/VIM/CREB3L1/MMP8/MMP1/MMP3/RGCC/MMP14/TGFB3/MMP2/MFAP4/COL1A1/MRC2/CST3/TGFB1/RCN3/RUNX1 | 32 |
| 8 | GO:0090287 | GO:0090287 | regulation of cellular response to growth factor stimulus | 55/700 | 345/18614 | 6.72549847110955e-20 | 4.05547557807906e-17 | 2.94771518516657e-17 | NBL1/AGT/GREM2/EMILIN1/LTBP1/CRIM1/ZEB2/TNFAIP6/GPC1/PPARG/WNT5A/MSX1/HTRA3/SLIT2/HHIP/VEGFC/DAB2/FOXD1/LOX/FBN2/FGF1/SCUBE3/RUNX2/CD109/BMPER/SFRP4/FZD1/CAV2/CAV1/ZNF703/SULF1/CDKN2B/ASPN/ENG/ZEB1/NRP1/DKK1/HTRA1/DKK3/CREB3L1/FAM89B/ACVRL1/ITGA5/DCN/TGFB3/GREM1/THBS1/FBN1/TMEM204/VASN/TGFB1I1/GATA6/GDF5/FSTL3/TGFB1 | 55 |
| 9 | GO:0007178 | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 58/700 | 398/18614 | 5.33535684429482e-19 | 2.85975126854202e-16 | 2.07860510506971e-16 | NBL1/FMOD/TGFB2/GREM2/EMILIN1/LTBP1/CRIM1/ATOH8/ZEB2/TNFAIP6/COL3A1/PPARG/TGFBR2/WNT5A/MSX1/HTRA3/DAB2/FOXD1/LOX/FBN2/SCUBE3/RUNX2/CD109/BMPER/SFRP4/INHBA/FZD1/COL1A2/CAV2/CAV1/ZNF703/ADAM9/SULF1/GDF6/CDKN2B/ASPN/ENG/VIM/ZEB1/DKK1/HTRA1/DKK3/LPXN/LTBP3/FAM89B/LRRC32/ACVRL1/LTBP2/TGFB3/GREM1/THBS1/FBN1/VASN/TGFB1I1/GATA6/GDF5/FSTL3/TGFB1 | 58 |
| 10 | GO:0051216 | GO:0051216 | cartilage development | 41/700 | 203/18614 | 6.28571507438577e-19 | 3.03222895188369e-16 | 2.20397020134516e-16 | ECM1/CTSK/PRRX1/EFEMP1/HOXD3/COL3A1/RARB/TGFBR2/WNT5A/MSX1/HAND2/PITX1/TGFBI/RUNX2/SCIN/HOXA3/HOXA5/HOXA11/TIMP1/BGN/CSGALNACT1/BMP1/LOXL2/SNAI2/SULF1/GDF6/OSR2/OGN/ZEB1/CD44/LTBP3/WNT5B/MGP/PTHLH/ACVRL1/GREM1/HOXB3/COL1A1/GDF5/TGFB1/WNT7B | 41 |
| 11 | GO:0048705 | GO:0048705 | skeletal system morphogenesis | 43/700 | 229/18614 | 1.5727360925964e-18 | 6.89716264607728e-16 | 5.01319035831444e-16 | TBX15/PRRX1/HOXD8/HOXD3/COL3A1/RARB/TGFBR2/MSX1/PDGFRA/HHIP/FBN2/FOXC1/RUNX2/TWIST1/HOXA3/HOXA4/HOXA5/HOXA9/HOXA11/SFRP4/CSGALNACT1/BMP1/OSR2/HAS2/ZEB1/ARID5B/LTBP3/MGP/HOXC9/TMEM119/MMP14/SIX1/TGFB3/GREM1/MMP2/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/COL1A1 | 43 |
| 12 | GO:0042060 | GO:0042060 | wound healing | 60/700 | 439/18614 | 3.09214230987511e-18 | 1.2430412085698e-15 | 9.03502283701228e-16 | F3/RHOC/S100A10/PEAR1/CSRP1/TGFB2/EMILIN1/PRKCE/CHMP3/FAP/COL3A1/SERPINE2/PPARG/TGFBR2/WNT5A/GATA2/PDGFRA/ARHGAP24/IL6ST/F2RL2/LOX/FGF1/PDGFRB/ADTRP/CDKN1A/CD109/IL6/TFPI2/SERPINE1/CAV1/MIR29A/TIMP1/SYTL4/PLAT/B4GALT1/ANXA1/TLR4/COL5A1/ACTA2/MYOF/SMPD1/CD59/CD44/AHNAK/WNT5B/ACVRL1/ITGA5/GAS6/TGFB3/THBS1/ANXA2/FOXC2/FKBP10/COL1A1/C1QTNF1/EMILIN2/THBD/MYL9/TGFB1/PLAUR | 60 |
| 13 | GO:0090092 | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 47/700 | 301/18614 | 8.43725901373852e-17 | 3.13087211402112e-14 | 2.27566880767312e-14 | NBL1/TGFB2/GREM2/EMILIN1/LTBP1/CRIM1/ZEB2/TNFAIP6/PPARG/TGFBR2/WNT5A/MSX1/HTRA3/DAB2/FOXD1/LOX/FBN2/SCUBE3/CD109/BMPER/SFRP4/INHBA/FZD1/CAV2/CAV1/ZNF703/SULF1/GDF6/CDKN2B/ASPN/ENG/ZEB1/DKK1/HTRA1/DKK3/FAM89B/ACVRL1/TGFB3/GREM1/THBS1/FBN1/VASN/TGFB1I1/GATA6/GDF5/FSTL3/TGFB1 | 47 |
| 14 | GO:0071559 | GO:0071559 | response to transforming growth factor beta | 45/700 | 280/18614 | 1.27078436975664e-16 | 4.37875985693287e-14 | 3.18269378621004e-14 | CTSK/FMOD/TGFB2/EMILIN1/LTBP1/ZEB2/COL3A1/PPARG/TGFBR2/WNT5A/HTRA3/DAB2/LOX/FBN2/CD109/COL1A2/CAV2/CAV1/WNT2/MXRA5/ZNF703/ADAM9/PENK/CDKN2B/ASPN/ENG/ZEB1/ACTA2/ANKRD1/HTRA1/DKK3/LPXN/LTBP3/FAM89B/LRRC32/ACVRL1/LTBP2/TGFB3/THBS1/FBN1/VASN/TGFB1I1/COL1A1/GDF5/TGFB1 | 45 |
| 15 | GO:0001667 | GO:0001667 | ameboidal-type cell migration | 61/700 | 496/18614 | 2.73698823890748e-16 | 8.69804859280986e-14 | 6.32216109423271e-14 | S100A2/PTGS2/TGFB2/AGT/CYP1B1/PRKCE/ATOH8/ZEB2/FAP/FN1/TNS1/SP100/PPARG/TGFBR2/WNT5A/GATA2/SLIT2/PITX2/HAND2/VEGFC/GDNF/FGF1/MIR145/SPARC/ADTRP/DAAM2/MEOX2/TWIST1/BMPER/SEMA3C/MIR29A/TIMP1/LOXL2/ADAM9/SNAI2/ANGPT1/ENPP2/HAS2/PRSS3/GLIPR2/ANXA1/KLF4/NRP1/VSTM4/ARID5B/ACTA2/LPXN/CD248/ACVRL1/DCN/RGCC/CLEC14A/GREM1/THBS1/FGF7/SEMA7A/CDH13/FOXC2/RIN2/SYDE1/TGFB1 | 61 |
| 16 | GO:0071560 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 44/700 | 274/18614 | 2.8849249064046e-16 | 8.69804859280986e-14 | 6.32216109423271e-14 | CTSK/FMOD/TGFB2/EMILIN1/LTBP1/ZEB2/COL3A1/PPARG/TGFBR2/WNT5A/HTRA3/DAB2/LOX/FBN2/CD109/COL1A2/CAV2/CAV1/WNT2/ZNF703/ADAM9/PENK/CDKN2B/ASPN/ENG/ZEB1/ACTA2/ANKRD1/HTRA1/DKK3/LPXN/LTBP3/FAM89B/LRRC32/ACVRL1/LTBP2/TGFB3/THBS1/FBN1/VASN/TGFB1I1/COL1A1/GDF5/TGFB1 | 44 |
| 17 | GO:0048562 | GO:0048562 | embryonic organ morphogenesis | 45/700 | 294/18614 | 8.39624548525598e-16 | 2.3825581306397e-13 | 1.73175812454413e-13 | TBX15/PRRX1/HLX/EFEMP1/VAX2/PAX8/BBS5/HOXD3/RARB/TGFBR2/WNT5A/GATA2/MSX1/PDGFRA/HAND2/FBN2/FOXF2/RUNX2/TBX18/TWIST1/HOXA3/HOXA4/HOXA5/HOXA9/HOXA11/OSR2/CTHRC1/ENG/ZEB1/MICAL2/MFAP5/HOXC9/TBX3/MMP14/SIX1/TGFB3/FBN1/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/TSHZ1 | 45 |
| 18 | GO:0048732 | GO:0048732 | gland development | 56/700 | 441/18614 | 1.18926495017022e-15 | 3.1872300664562e-13 | 2.31663248480527e-13 | WLS/CSF1/TGFB2/HLX/CYP1B1/PAX8/LIMS2/HOXD3/IGFBP5/SERPINE2/OXTR/TGFBR2/WNT5A/GATA2/MSX1/PDGFRA/PITX2/HAND2/PITX1/FGF1/FOXC1/IL6/HOXA3/HOXA5/HOXA9/HOXA11/SEMA3C/HGF/CAV1/WNT2/ZNF703/SNAI2/SULF1/TG/CDKN2B/ANXA1/TNC/NRP1/ARID5B/IGF2/DKK3/VDR/NTN4/OAS2/TBX3/SIX1/TGFB3/FGF7/MMP2/HOXB3/HOXB9/GATA6/TGM2/TGFB1/TSPO/WNT7B | 56 |
| 19 | GO:0007389 | GO:0007389 | pattern specification process | 57/700 | 467/18614 | 3.82926052407018e-15 | 9.35102527047187e-13 | 6.79677602687043e-13 | NBL1/WLS/PLXNA2/GREM2/MEIS1/VAX2/RFX8/PAX8/BBS5/HOXD8/HOXD3/BHLHE40/TGFBR2/WNT5A/MSX1/PITX2/HHIP/HAND2/GDNF/FOXD1/FGF1/FOXC1/DAAM2/TBX18/MEOX2/HOXA3/HOXA4/HOXA5/HOXA9/HOXA10/HOXA11/SEMA3C/WNT2/BMP1/ENG/ZEB1/NRP1/DKK1/BICC1/MICAL2/ACVRL1/HOXC10/HOXC9/TBX5/TBX3/SIX1/GREM1/MEIS2/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/TSHZ1/WNT7B | 57 |
| 20 | GO:0048568 | GO:0048568 | embryonic organ development | 56/700 | 453/18614 | 3.87687614862018e-15 | 9.35102527047187e-13 | 6.79677602687043e-13 | TBX15/PRRX1/TGFB2/HLX/EPAS1/EFEMP1/VAX2/PAX8/BBS5/HOXD3/RARB/TGFBR2/WNT5A/GATA2/MSX1/PDGFRA/PITX2/HAND2/GDNF/FBN2/FOXF2/FOXC1/RUNX2/TBX18/TWIST1/HOXA3/HOXA4/HOXA5/HOXA9/HOXA11/WNT2/OSR2/CTHRC1/ZFPM2/ENG/ZEB1/IGF2/MICAL2/MFAP5/HOXC9/TBX3/MMP14/SIX1/TGFB3/FBN1/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/TSHZ1/JUNB/TGFB1/WNT7B | 56 |
| 21 | GO:0048706 | GO:0048706 | embryonic skeletal system development | 29/700 | 129/18614 | 4.71338112180511e-15 | 1.08273097769466e-12 | 7.86981078532974e-13 | TBX15/PRRX1/HOXD3/TGFBR2/WNT5A/PDGFRA/HAND2/RUNX2/TWIST1/HOXA3/HOXA4/HOXA5/HOXA9/HOXA11/SULF1/OSR2/ZEB1/HOXC9/MMP14/SIX1/TGFB3/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/COL1A1 | 29 |
| 22 | GO:0050673 | GO:0050673 | epithelial cell proliferation | 58/700 | 488/18614 | 7.13540122673626e-15 | 1.5368761867734e-12 | 1.11707571313219e-12 | COL8A2/F3/ECM1/TGFB2/HLX/ATOH8/LIMS2/FAP/IGFBP5/PPARG/WNT5A/COL8A1/GATA2/VEGFC/DAB2/FGF1/SPARC/RUNX2/CD109/TWIST1/IL6/HOXA5/BMPER/IGFBP3/HGF/CAV2/CAV1/WNT2/MIR29A/LOXL2/ZNF703/SNAI2/SULF1/OSR2/HAS2/CDKN2B/B4GALT1/KLF9/ZEB1/NRP1/VSTM4/HTRA1/IGF2/NEAT1/VDR/ACVRL1/RGCC/MMP14/SIX1/THBS1/B2M/FGF7/NUPR1/CDH13/CCL2/IGFBP4/GDF5/TGFB1 | 58 |
| 23 | GO:0048704 | GO:0048704 | embryonic skeletal system morphogenesis | 25/700 | 95/18614 | 7.32756059199589e-15 | 1.5368761867734e-12 | 1.11707571313219e-12 | TBX15/PRRX1/HOXD3/TGFBR2/PDGFRA/RUNX2/TWIST1/HOXA3/HOXA4/HOXA5/HOXA9/HOXA11/OSR2/ZEB1/HOXC9/MMP14/SIX1/TGFB3/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9 | 25 |
| 24 | GO:0003002 | GO:0003002 | regionalization | 53/700 | 422/18614 | 1.13357218884415e-14 | 2.26476994916018e-12 | 1.64614399507999e-12 | NBL1/WLS/PLXNA2/GREM2/VAX2/RFX8/PAX8/BBS5/HOXD8/HOXD3/BHLHE40/TGFBR2/WNT5A/MSX1/PITX2/HHIP/HAND2/GDNF/FOXD1/FGF1/FOXC1/DAAM2/TBX18/MEOX2/HOXA3/HOXA4/HOXA5/HOXA9/HOXA10/HOXA11/SEMA3C/WNT2/BMP1/ENG/NRP1/DKK1/BICC1/MICAL2/ACVRL1/HOXC10/HOXC9/TBX3/SIX1/GREM1/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/TSHZ1/WNT7B | 53 |
| 25 | GO:0007179 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 37/700 | 218/18614 | 1.17369918592464e-14 | 2.26476994916018e-12 | 1.64614399507999e-12 | FMOD/TGFB2/EMILIN1/LTBP1/ZEB2/COL3A1/PPARG/TGFBR2/HTRA3/DAB2/LOX/FBN2/CD109/COL1A2/CAV2/CAV1/ZNF703/ADAM9/CDKN2B/ASPN/ENG/ZEB1/HTRA1/DKK3/LPXN/LTBP3/FAM89B/LRRC32/ACVRL1/LTBP2/TGFB3/THBS1/FBN1/VASN/TGFB1I1/GDF5/TGFB1 | 37 |
| 26 | GO:0060537 | GO:0060537 | muscle tissue development | 53/700 | 426/18614 | 1.67805230608603e-14 | 3.11343243252269e-12 | 2.26299280630468e-12 | HIVEP3/LMNA/RGS4/CSRP1/KCNK2/TGFB2/HLX/AGT/VAMP5/FHL2/COL3A1/IGFBP5/GPC1/RARB/TGFBR2/WNT5A/HEG1/MSX1/PDGFRA/LOX/PITX1/MIR145/PDGFRB/SGCD/FOXC1/PI16/TBX18/MEOX2/TWIST1/ELN/SEMA3C/CAV2/CAV1/WNT2/MSC/ZFPM2/ENG/DKK1/ANKRD1/IGF2/EFEMP2/TBX5/TBX3/SIX1/GREM1/NUPR1/FOXC2/GATA6/ALPK2/TGFB1/MAPK11/RCAN1/RUNX1 | 53 |
| 27 | GO:0031589 | GO:0031589 | cell-substrate adhesion | 48/700 | 359/18614 | 1.94723576308962e-14 | 3.47906123005345e-12 | 2.52874944516628e-12 | COL16A1/CSF1/ITGA10/S100A10/EMILIN1/PRKCE/LIMS2/HOXD3/COL3A1/FN1/SNED1/FBLN2/COL8A1/ABI3BP/CCDC80/BST1/EGFLAM/DAB2/SPOCK1/SERPINE1/DLC1/ADAM9/ANGPT1/HAS2/CDKN2A/ECM2/NRP1/PARVA/CD44/LPXN/EFEMP2/ACVRL1/ITGA5/NTN4/THSD1/GAS6/MMP14/NID2/FBLN5/GREM1/THBS1/ITGA11/CDH11/CDH13/COL1A1/RIN2/COL5A3/RAC2 | 48 |
| 28 | GO:0060485 | GO:0060485 | mesenchyme development | 45/700 | 320/18614 | 2.0515593528921e-14 | 3.53454368512554e-12 | 2.56907676860286e-12 | S100A4/TGFB2/FN1/TGFBR2/WNT5A/MSX1/PITX2/HAND2/GDNF/DAB2/FOXD1/MIR145/PDGFRB/FOXF2/FOXC1/TWIST1/IL6/HOXA5/SEMA3C/HGF/WNT2/LOXL2/ZNF703/SNAI2/ZFPM2/HAS2/GLIPR2/ENG/NRP1/DKK1/ACTA2/ACVRL1/TBX5/TBX3/RGCC/SIX1/TGFB3/GREM1/SEMA7A/VASN/TGFB1I1/FOXC2/COL1A1/TGFB1/ADAMTS5 | 45 |
| 29 | GO:0045765 | GO:0045765 | regulation of angiogenesis | 46/700 | 349/18614 | 1.17715543952012e-13 | 1.9581371862914e-11 | 1.42326851870836e-11 | F3/ECM1/TGFB2/AGT/EMILIN1/CYP1B1/SP100/PPARG/TGFBR2/WNT5A/GATA2/VEGFC/FGF1/MIR145/SPARC/FOXC1/THBS2/TWIST1/IL6/GPNMB/HOXA5/BMPER/HGF/SERPINE1/MIR29A/SULF1/KLF4/ENG/NRP1/ADAM12/RNH1/CREB3L1/ACVRL1/ITGA5/DCN/RGCC/GREM1/THBS1/FOXC2/SPHK1/EMILIN2/GATA6/KLF2/HSPB6/ADAMTS1/RUNX1 | 46 |
| 30 | GO:0090130 | GO:0090130 | tissue migration | 48/700 | 379/18614 | 1.55247210639296e-13 | 2.47623924546154e-11 | 1.79985007563768e-11 | S100A2/PTGS2/TGFB2/AGT/CYP1B1/PRKCE/ATOH8/ZEB2/FAP/SP100/PPARG/TGFBR2/WNT5A/GATA2/SLIT2/VEGFC/FGF1/SPARC/ADTRP/DAAM2/MEOX2/BMPER/MIR29A/LOXL2/ADAM9/SNAI2/ANGPT1/ENPP2/HAS2/PRSS3/GLIPR2/ANXA1/KLF4/NRP1/VSTM4/ACTA2/LPXN/ACVRL1/DCN/RGCC/CLEC14A/GREM1/THBS1/FGF7/CDH13/FOXC2/RIN2/TGFB1 | 48 |
| 31 | GO:0032964 | GO:0032964 | collagen biosynthetic process | 18/700 | 51/18614 | 1.59128143883308e-13 | 2.47623924546154e-11 | 1.79985007563768e-11 | EMILIN1/MIR145/PDGFRB/TRAM2/IL6/INHBA/PCOLCE/MIR29A/ENG/COL5A1/VIM/CREB3L1/RGCC/TGFB3/COL1A1/TGFB1/RCN3/RUNX1 | 18 |
| 32 | GO:0033002 | GO:0033002 | muscle cell proliferation | 38/700 | 249/18614 | 1.69464323411586e-13 | 2.55467467542965e-11 | 1.85686072790787e-11 | PTGS2/KCNK2/TGFB2/AGT/IGFBP5/PPARG/TGFBR2/IL15/NPR3/MIR145/PDGFRB/FOXC1/CDKN1A/GPER1/IL6/IGFBP3/ELN/HGF/CAV2/WNT2/ZFPM2/ANGPT1/OGN/TLR4/EFEMP2/TBX5/SIX1/TGFB3/THBS1/MMP2/CDH13/FOXC2/GATA6/TGFB1/PTGIR/MAPK11/ADAMTS1/RUNX1 | 38 |
| 33 | GO:0003007 | GO:0003007 | heart morphogenesis | 39/700 | 262/18614 | 1.83938180241176e-13 | 2.68884176207101e-11 | 1.95437983535361e-11 | TGFB2/FHL2/BBS5/TGFBR2/WNT5A/HEG1/MSX1/SLIT2/PITX2/HAND2/SLIT3/FOXC1/TWIST1/ELN/SEMA3C/FZD1/WNT2/DLC1/SNAI2/ZFPM2/HAS2/ENG/COL5A1/NRP1/DKK1/ANKRD1/MICAL2/PARVA/ACVRL1/TBX5/TBX3/SIX1/FLRT2/FOXC2/GATA6/ALPK2/TGFB1/ADAMTS1/ADAMTS5 | 39 |
| 34 | GO:1901342 | GO:1901342 | regulation of vasculature development | 46/700 | 355/18614 | 2.20240714631485e-13 | 3.12482708053613e-11 | 2.27127498587454e-11 | F3/ECM1/TGFB2/AGT/EMILIN1/CYP1B1/SP100/PPARG/TGFBR2/WNT5A/GATA2/VEGFC/FGF1/MIR145/SPARC/FOXC1/THBS2/TWIST1/IL6/GPNMB/HOXA5/BMPER/HGF/SERPINE1/MIR29A/SULF1/KLF4/ENG/NRP1/ADAM12/RNH1/CREB3L1/ACVRL1/ITGA5/DCN/RGCC/GREM1/THBS1/FOXC2/SPHK1/EMILIN2/GATA6/KLF2/HSPB6/ADAMTS1/RUNX1 | 46 |
| 35 | GO:0010631 | GO:0010631 | epithelial cell migration | 47/700 | 371/18614 | 2.77581911442852e-13 | 3.82587183085805e-11 | 2.78082811132674e-11 | S100A2/PTGS2/TGFB2/AGT/CYP1B1/PRKCE/ATOH8/ZEB2/FAP/SP100/PPARG/TGFBR2/WNT5A/GATA2/SLIT2/VEGFC/FGF1/SPARC/ADTRP/DAAM2/MEOX2/BMPER/MIR29A/LOXL2/ADAM9/SNAI2/ANGPT1/ENPP2/HAS2/PRSS3/GLIPR2/ANXA1/KLF4/NRP1/VSTM4/LPXN/ACVRL1/DCN/RGCC/CLEC14A/GREM1/THBS1/FGF7/CDH13/FOXC2/RIN2/TGFB1 | 47 |
| 36 | GO:0090132 | GO:0090132 | epithelium migration | 47/700 | 374/18614 | 3.73865778172962e-13 | 5.00980142751769e-11 | 3.64136522542145e-11 | S100A2/PTGS2/TGFB2/AGT/CYP1B1/PRKCE/ATOH8/ZEB2/FAP/SP100/PPARG/TGFBR2/WNT5A/GATA2/SLIT2/VEGFC/FGF1/SPARC/ADTRP/DAAM2/MEOX2/BMPER/MIR29A/LOXL2/ADAM9/SNAI2/ANGPT1/ENPP2/HAS2/PRSS3/GLIPR2/ANXA1/KLF4/NRP1/VSTM4/LPXN/ACVRL1/DCN/RGCC/CLEC14A/GREM1/THBS1/FGF7/CDH13/FOXC2/RIN2/TGFB1 | 47 |
| 37 | GO:0060348 | GO:0060348 | bone development | 36/700 | 235/18614 | 6.61786852919562e-13 | 8.62826967157829e-11 | 6.27144240988637e-11 | ECM1/MEIS1/COL3A1/RARB/TGFBR2/MSX1/PITX2/PDGFC/PTGER4/LOX/FOXC1/RUNX2/TWIST1/HOXA11/SFRP4/LRRC17/BGN/CSGALNACT1/SULF1/OSR2/HAS2/OGN/ENG/LTBP3/FLI1/TMEM119/MMP14/TGFB3/GPR68/GREM1/FBN1/ANXA2/HOXB4/COL1A1/TGM2/MAPK11 | 36 |
| 38 | GO:0001649 | GO:0001649 | osteoblast differentiation | 37/700 | 250/18614 | 9.26250819842828e-13 | 1.1758510407689e-10 | 8.54665230165224e-11 | CRIM1/FHL2/TNFAIP6/IGFBP5/TWIST2/PPARG/HAND2/VEGFC/IL6ST/LOX/FBN2/SCUBE3/RUNX2/TWIST1/IL6/IGFBP3/HGF/FZD1/CEBPD/SNAI2/PENK/CTHRC1/TNC/IGF2/CREB3L1/PTHLH/TMEM119/GREM1/ITGA11/SEMA7A/COL1A1/MRC2/ZHX3/JUNB/WNT7B/MAPK11/COL6A1 | 37 |
| 39 | GO:0048762 | GO:0048762 | mesenchymal cell differentiation | 37/700 | 255/18614 | 1.70968604384282e-12 | 2.11475012192251e-10 | 1.53710235142792e-10 | S100A4/TGFB2/FN1/TGFBR2/WNT5A/MSX1/PITX2/HAND2/GDNF/DAB2/MIR145/FOXF2/FOXC1/TWIST1/IL6/SEMA3C/HGF/WNT2/LOXL2/ZNF703/SNAI2/HAS2/GLIPR2/ENG/NRP1/TBX5/TBX3/RGCC/SIX1/TGFB3/GREM1/SEMA7A/VASN/TGFB1I1/FOXC2/COL1A1/TGFB1 | 37 |
| 40 | GO:0010712 | GO:0010712 | regulation of collagen metabolic process | 16/700 | 46/18614 | 4.67486063864184e-12 | 5.63788193020206e-10 | 4.09788441771473e-10 | EMILIN1/FAP/MIR145/PDGFRB/IL6/INHBA/MIR29A/ENG/VIM/CREB3L1/RGCC/TGFB3/MFAP4/CST3/TGFB1/RUNX1 | 16 |
| 41 | GO:0085029 | GO:0085029 | extracellular matrix assembly | 15/700 | 42/18614 | 1.40737064773843e-11 | 1.65589170846102e-09 | 1.20358193263587e-09 | AGT/EMILIN1/COL3A1/LOX/ELN/COL1A2/HAS2/EFEMP2/NTN4/RGCC/GAS6/FBLN5/MFAP4/FKBP10/TGFB1 | 15 |
| 42 | GO:0030509 | GO:0030509 | BMP signaling pathway | 29/700 | 176/18614 | 1.90594745784729e-11 | 2.18911679444174e-09 | 1.59115563460885e-09 | NBL1/TGFB2/GREM2/CRIM1/TNFAIP6/PPARG/WNT5A/MSX1/HTRA3/FOXD1/SCUBE3/RUNX2/BMPER/SFRP4/INHBA/FZD1/SULF1/GDF6/ENG/DKK1/HTRA1/ACVRL1/TGFB3/GREM1/FBN1/GATA6/GDF5/FSTL3/TGFB1 | 29 |
| 43 | GO:0061138 | GO:0061138 | morphogenesis of a branching epithelium | 30/700 | 188/18614 | 1.97053945890306e-11 | 2.21067031389496e-09 | 1.60682177175179e-09 | CSF1/AGT/PAX8/TGFBR2/WNT5A/SLIT2/HHIP/GDNF/FOXD1/FGF1/HOXA5/HOXA11/SEMA3C/HGF/WNT2/SNAI2/SULF1/ENG/NRP1/VDR/NTN4/TBX3/MMP14/SIX1/GREM1/FGF7/FOXC2/HOXB7/TGM2/CTSZ | 30 |
| 44 | GO:0002683 | GO:0002683 | negative regulation of immune system process | 51/700 | 487/18614 | 3.90623593051354e-11 | 4.25220936400217e-09 | 3.09071078630777e-09 | TNFRSF14/NBL1/PTPN22/IFI16/FCRLB/TNFSF4/TGFB2/HLX/EMILIN1/TNFAIP6/COL3A1/FN1/PPARG/PARP3/GATA2/SLIT2/IL7R/PTGER4/IRF1/DUSP1/ADTRP/GPER1/TWIST1/GPNMB/INHBA/LRRC17/SNAI2/PAG1/ANGPT1/PDCD1LG2/ANXA1/SVEP1/TLR4/CD59/LPXN/LRRC32/OAS1/LGALS3/TGFB3/GPR68/RIN3/GREM1/THBS1/FBN1/CD68/CCL2/PRNP/FSTL3/TGFB1/IL4I1/RUNX1 | 51 |
| 45 | GO:0043542 | GO:0043542 | endothelial cell migration | 37/700 | 283/18614 | 3.9666132126886e-11 | 4.25220936400217e-09 | 3.09071078630777e-09 | S100A2/PTGS2/AGT/CYP1B1/ATOH8/FAP/SP100/PPARG/WNT5A/GATA2/SLIT2/VEGFC/FGF1/SPARC/ADTRP/MEOX2/BMPER/MIR29A/LOXL2/SNAI2/ANGPT1/PRSS3/ANXA1/KLF4/NRP1/VSTM4/LPXN/ACVRL1/DCN/RGCC/CLEC14A/GREM1/THBS1/CDH13/FOXC2/RIN2/TGFB1 | 37 |
| 46 | GO:0014706 | GO:0014706 | striated muscle tissue development | 35/700 | 259/18614 | 5.31281313358277e-11 | 5.57152403400071e-09 | 4.04965229930531e-09 | LMNA/RGS4/KCNK2/TGFB2/AGT/FHL2/RARB/TGFBR2/WNT5A/HEG1/MSX1/PDGFRA/LOX/PDGFRB/SGCD/FOXC1/PI16/TBX18/TWIST1/SEMA3C/WNT2/MSC/ZFPM2/ENG/DKK1/ANKRD1/TBX5/TBX3/GREM1/FOXC2/GATA6/ALPK2/TGFB1/MAPK11/RUNX1 | 35 |
| 47 | GO:0001837 | GO:0001837 | epithelial to mesenchymal transition | 28/700 | 172/18614 | 5.70859779937715e-11 | 5.85920761365859e-09 | 4.25875459568316e-09 | S100A4/TGFB2/TGFBR2/WNT5A/MSX1/DAB2/MIR145/FOXF2/FOXC1/TWIST1/IL6/HGF/WNT2/LOXL2/ZNF703/SNAI2/HAS2/GLIPR2/ENG/TBX5/TBX3/RGCC/TGFB3/GREM1/VASN/TGFB1I1/COL1A1/TGFB1 | 28 |
| 48 | GO:0030510 | GO:0030510 | regulation of BMP signaling pathway | 23/700 | 118/18614 | 7.20971061589167e-11 | 7.24575916897112e-09 | 5.26656711875771e-09 | NBL1/GREM2/CRIM1/TNFAIP6/PPARG/WNT5A/MSX1/HTRA3/FOXD1/SCUBE3/BMPER/SFRP4/FZD1/SULF1/ENG/DKK1/HTRA1/ACVRL1/GREM1/FBN1/GATA6/GDF5/FSTL3 | 23 |
| 49 | GO:0050678 | GO:0050678 | regulation of epithelial cell proliferation | 46/700 | 419/18614 | 7.56544203904263e-11 | 7.44810048904931e-09 | 5.41363854609044e-09 | F3/ECM1/TGFB2/HLX/ATOH8/LIMS2/PPARG/WNT5A/GATA2/VEGFC/DAB2/FGF1/SPARC/RUNX2/CD109/TWIST1/HOXA5/CAV2/CAV1/WNT2/MIR29A/ZNF703/SNAI2/SULF1/OSR2/HAS2/CDKN2B/B4GALT1/KLF9/ZEB1/NRP1/HTRA1/IGF2/NEAT1/VDR/ACVRL1/RGCC/SIX1/THBS1/B2M/FGF7/NUPR1/CDH13/CCL2/GDF5/TGFB1 | 46 |
| 50 | GO:0071772 | GO:0071772 | response to BMP | 29/700 | 187/18614 | 8.70556336492993e-11 | 8.23443875929843e-09 | 5.98518711425833e-09 | NBL1/TGFB2/GREM2/CRIM1/TNFAIP6/PPARG/WNT5A/MSX1/HTRA3/FOXD1/SCUBE3/RUNX2/BMPER/SFRP4/INHBA/FZD1/SULF1/GDF6/ENG/DKK1/HTRA1/ACVRL1/TGFB3/GREM1/FBN1/GATA6/GDF5/FSTL3/TGFB1 | 29 |
| 51 | GO:0071773 | GO:0071773 | cellular response to BMP stimulus | 29/700 | 187/18614 | 8.70556336492993e-11 | 8.23443875929843e-09 | 5.98518711425833e-09 | NBL1/TGFB2/GREM2/CRIM1/TNFAIP6/PPARG/WNT5A/MSX1/HTRA3/FOXD1/SCUBE3/RUNX2/BMPER/SFRP4/INHBA/FZD1/SULF1/GDF6/ENG/DKK1/HTRA1/ACVRL1/TGFB3/GREM1/FBN1/GATA6/GDF5/FSTL3/TGFB1 | 29 |
| 52 | GO:0060021 | GO:0060021 | roof of mouth development | 20/700 | 91/18614 | 1.30059145625358e-10 | 1.20654868941678e-08 | 8.76977761291632e-09 | PRRX1/TGFB2/TGFBR2/WNT5A/MSX1/PDGFRA/HAND2/FOXF2/MEOX2/TWIST1/INHBA/FZD1/SNAI2/MSC/OSR2/ARID5B/LRRC32/TBX3/TGFB3/TSHZ1 | 20 |
| 53 | GO:0001763 | GO:0001763 | morphogenesis of a branching structure | 30/700 | 203/18614 | 1.39912843573461e-10 | 1.27347086301581e-08 | 9.25620023720357e-09 | CSF1/AGT/PAX8/TGFBR2/WNT5A/SLIT2/HHIP/GDNF/FOXD1/FGF1/HOXA5/HOXA11/SEMA3C/HGF/WNT2/SNAI2/SULF1/ENG/NRP1/VDR/NTN4/TBX3/MMP14/SIX1/GREM1/FGF7/FOXC2/HOXB7/TGM2/CTSZ | 30 |
| 54 | GO:0022612 | GO:0022612 | gland morphogenesis | 23/700 | 123/18614 | 1.73308345209911e-10 | 1.54822121720854e-08 | 1.12532182825383e-08 | CSF1/TGFB2/LIMS2/IGFBP5/TGFBR2/WNT5A/FGF1/IL6/SEMA3C/HGF/CAV1/SNAI2/SULF1/TNC/NRP1/VDR/NTN4/TBX3/TGFB3/FGF7/MMP2/TGM2/TGFB1 | 23 |
| 55 | GO:0007162 | GO:0007162 | negative regulation of cell adhesion | 38/700 | 312/18614 | 1.78508067304085e-10 | 1.56567803031801e-08 | 1.13801028170317e-08 | TNFRSF14/PTPN22/TNFSF4/PLXNA2/HLX/CYP1B1/SERPINE2/IRF1/TGFBI/SPOCK1/DUSP1/ADTRP/GPNMB/SERPINE1/DLC1/ZNF703/SNAI2/PAG1/ANGPT1/PDCD1LG2/CDKN2A/ANXA1/KLF4/LPXN/LRRC32/ACVRL1/RGCC/MMP14/LGALS3/THBS1/MMP2/CDH13/COL1A1/C1QTNF1/PRNP/TGFB1/IL4I1/RUNX1 | 38 |
| 56 | GO:0048771 | GO:0048771 | tissue remodeling | 28/700 | 181/18614 | 1.95390322146263e-10 | 1.67757631425204e-08 | 1.21934334964946e-08 | CTSK/AGT/EPAS1/IGFBP5/PPARG/IL15/HAND2/NPR3/FOXC1/IL6/GPNMB/HOXA3/SEMA3C/CAV1/TIMP1/CTHRC1/LTBP3/VDR/ACVRL1/TMEM119/MMP14/GREM1/MMP2/FOXC2/CST3/GDF5/TGFB1/RUNX1 | 28 |
| 57 | GO:0035107 | GO:0035107 | appendage morphogenesis | 25/700 | 146/18614 | 2.0169864474838e-10 | 1.67757631425204e-08 | 1.21934334964946e-08 | PRRX1/PLXNA2/TGFB2/AFF3/COL3A1/RARB/WNT5A/MBNL1/MSX1/HAND2/FBN2/PITX1/RUNX2/TWIST1/HOXA9/HOXA10/HOXA11/SEMA3C/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 25 |
| 58 | GO:0035108 | GO:0035108 | limb morphogenesis | 25/700 | 146/18614 | 2.0169864474838e-10 | 1.67757631425204e-08 | 1.21934334964946e-08 | PRRX1/PLXNA2/TGFB2/AFF3/COL3A1/RARB/WNT5A/MBNL1/MSX1/HAND2/FBN2/PITX1/RUNX2/TWIST1/HOXA9/HOXA10/HOXA11/SEMA3C/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 25 |
| 59 | GO:1901654 | GO:1901654 | response to ketone | 30/700 | 208/18614 | 2.57313636315577e-10 | 2.10386607048533e-08 | 1.52919129806813e-08 | PTGFR/TNFSF4/TGFB2/CYP1B1/PRKCE/OXTR/SLIT2/IGFBP7/PTGER4/SLIT3/SGK1/HOXA9/HOXA11/CAV1/PLAT/FBXO32/KLF9/PAPPA/AKR1C2/FIBIN/FOSL1/POSTN/GAS6/PTGER2/TGFB3/THBS1/NQO1/KLF2/TGFB1/TSPO | 30 |
| 60 | GO:0045785 | GO:0045785 | positive regulation of cell adhesion | 49/700 | 482/18614 | 2.6900564139767e-10 | 2.15412733264075e-08 | 1.56572360675271e-08 | TNFRSF14/COL16A1/CSF1/PTPN22/S100A10/TNFSF4/TGFB2/HLX/KIF26B/EMILIN1/PRKCE/LIMS2/FN1/FBLN2/TGFBR2/WNT5A/COL8A1/ABI3BP/CCDC80/IL15/IL7R/EGFLAM/DAB2/IL6ST/IL6/CAV1/ADAM9/ANGPT1/HAS2/PDCD1LG2/ANXA1/ECM2/NRP1/IGF2/CD44/EFEMP2/ITGA5/B2M/CDH13/FOXC2/CCL2/EMILIN2/RIN2/TGM2/FSTL3/PLAUR/IL4I1/LGALS1/RUNX1 | 49 |
| 61 | GO:0017015 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 25/700 | 148/18614 | 2.72391723240227e-10 | 2.15412733264075e-08 | 1.56572360675271e-08 | EMILIN1/LTBP1/ZEB2/PPARG/HTRA3/DAB2/LOX/FBN2/CD109/CAV2/CAV1/ZNF703/CDKN2B/ASPN/ENG/ZEB1/HTRA1/DKK3/FAM89B/TGFB3/THBS1/FBN1/VASN/TGFB1I1/TGFB1 | 25 |
| 62 | GO:0009952 | GO:0009952 | anterior/posterior pattern specification | 30/700 | 209/18614 | 2.89947293342968e-10 | 2.25597700497819e-08 | 1.63975285929614e-08 | WLS/PLXNA2/HOXD8/HOXD3/BHLHE40/WNT5A/MSX1/FOXC1/TBX18/MEOX2/HOXA3/HOXA4/HOXA5/HOXA9/HOXA10/HOXA11/SEMA3C/WNT2/DKK1/HOXC10/HOXC9/TBX3/FOXC2/HOXB2/HOXB3/HOXB4/HOXB5/HOXB7/HOXB9/TSHZ1 | 30 |
| 63 | GO:0010810 | GO:0010810 | regulation of cell-substrate adhesion | 31/700 | 222/18614 | 2.9568524992864e-10 | 2.26410419945359e-08 | 1.64566009609407e-08 | COL16A1/CSF1/S100A10/EMILIN1/PRKCE/LIMS2/FN1/FBLN2/COL8A1/ABI3BP/CCDC80/BST1/EGFLAM/DAB2/SPOCK1/SERPINE1/DLC1/HAS2/CDKN2A/ECM2/NRP1/EFEMP2/ACVRL1/ITGA5/MMP14/GREM1/THBS1/CDH13/COL1A1/RIN2/RAC2 | 31 |
| 64 | GO:0045766 | GO:0045766 | positive regulation of angiogenesis | 28/700 | 185/18614 | 3.28714333805425e-10 | 2.43956607119595e-08 | 1.77319424438198e-08 | F3/ECM1/EMILIN1/CYP1B1/TGFBR2/WNT5A/GATA2/VEGFC/FGF1/TWIST1/BMPER/HGF/SERPINE1/MIR29A/KLF4/ENG/NRP1/ADAM12/ACVRL1/ITGA5/GREM1/THBS1/FOXC2/SPHK1/EMILIN2/GATA6/HSPB6/RUNX1 | 28 |
| 65 | GO:1904018 | GO:1904018 | positive regulation of vasculature development | 28/700 | 185/18614 | 3.28714333805425e-10 | 2.43956607119595e-08 | 1.77319424438198e-08 | F3/ECM1/EMILIN1/CYP1B1/TGFBR2/WNT5A/GATA2/VEGFC/FGF1/TWIST1/BMPER/HGF/SERPINE1/MIR29A/KLF4/ENG/NRP1/ADAM12/ACVRL1/ITGA5/GREM1/THBS1/FOXC2/SPHK1/EMILIN2/GATA6/HSPB6/RUNX1 | 28 |
| 66 | GO:0042692 | GO:0042692 | muscle cell differentiation | 44/700 | 410/18614 | 4.10283541410807e-10 | 2.99879970267535e-08 | 2.17967221122711e-08 | LMNA/RGS4/CSRP1/CAPN2/AGT/LBX2/FHL2/IGFBP5/RARB/MSX1/PDGFRA/LOX/MIR145/PDGFRB/SGCD/PI16/TBX18/SYNE1/GPER1/CAV2/ENG/ZEB1/DKK1/MYPN/ANKRD1/ADAM12/IGF2/EFEMP2/WNT5B/TMEM119/TBX5/TBX3/MMP14/SIX1/GREM1/TMEM204/GATA6/ALPK2/MYL9/TGFB1/EHD2/MAPK11/ADAMTS5/RCAN1 | 44 |
| 67 | GO:1903844 | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 25/700 | 151/18614 | 4.23169371753183e-10 | 3.04681947662292e-08 | 2.21457529820872e-08 | EMILIN1/LTBP1/ZEB2/PPARG/HTRA3/DAB2/LOX/FBN2/CD109/CAV2/CAV1/ZNF703/CDKN2B/ASPN/ENG/ZEB1/HTRA1/DKK3/FAM89B/TGFB3/THBS1/FBN1/VASN/TGFB1I1/TGFB1 | 25 |
| 68 | GO:0007517 | GO:0007517 | muscle organ development | 40/700 | 351/18614 | 4.43767674925392e-10 | 3.14814009388249e-08 | 2.28822000801313e-08 | HIVEP3/TGFB2/HLX/VAMP5/COL3A1/COL6A3/GPC1/WNT5A/HEG1/MSX1/LOX/PITX1/MIR145/SGCD/FOXC1/MEOX2/TWIST1/ELN/FZD1/CAV2/CAV1/WNT2/MSC/ZFPM2/ENG/ARID5B/ANKRD1/IGF2/EFEMP2/CRYAB/TAGLN/SIX1/DPF3/ITGA11/NUPR1/CTF1/FOXC2/TGFB1/SMTN/RCAN1 | 40 |
| 69 | GO:0030326 | GO:0030326 | embryonic limb morphogenesis | 22/700 | 120/18614 | 6.4153941151272e-10 | 4.42112303019623e-08 | 3.21348538308101e-08 | PRRX1/TGFB2/AFF3/RARB/WNT5A/MBNL1/MSX1/HAND2/FBN2/PITX1/RUNX2/TWIST1/HOXA9/HOXA10/HOXA11/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 22 |
| 70 | GO:0035113 | GO:0035113 | embryonic appendage morphogenesis | 22/700 | 120/18614 | 6.4153941151272e-10 | 4.42112303019623e-08 | 3.21348538308101e-08 | PRRX1/TGFB2/AFF3/RARB/WNT5A/MBNL1/MSX1/HAND2/FBN2/PITX1/RUNX2/TWIST1/HOXA9/HOXA10/HOXA11/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 22 |
| 71 | GO:0048738 | GO:0048738 | cardiac muscle tissue development | 32/700 | 243/18614 | 6.97020047001192e-10 | 4.73580944610387e-08 | 3.44221464278869e-08 | LMNA/RGS4/KCNK2/TGFB2/AGT/FHL2/RARB/TGFBR2/WNT5A/HEG1/MSX1/PDGFRA/PDGFRB/SGCD/FOXC1/PI16/TBX18/WNT2/MSC/ZFPM2/ENG/DKK1/ANKRD1/TBX5/TBX3/GREM1/FOXC2/GATA6/ALPK2/TGFB1/MAPK11/RUNX1 | 32 |
| 72 | GO:0048736 | GO:0048736 | appendage development | 27/700 | 182/18614 | 1.07389756548458e-09 | 7.09655048753099e-08 | 5.15811505498074e-08 | PRRX1/PLXNA2/TGFB2/AFF3/COL3A1/RARB/WNT5A/MBNL1/MSX1/PITX2/HAND2/FBN2/PITX1/RUNX2/MEOX2/TWIST1/HOXA9/HOXA10/HOXA11/SEMA3C/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 27 |
| 73 | GO:0060173 | GO:0060173 | limb development | 27/700 | 182/18614 | 1.07389756548458e-09 | 7.09655048753099e-08 | 5.15811505498074e-08 | PRRX1/PLXNA2/TGFB2/AFF3/COL3A1/RARB/WNT5A/MBNL1/MSX1/PITX2/HAND2/FBN2/PITX1/RUNX2/MEOX2/TWIST1/HOXA9/HOXA10/HOXA11/SEMA3C/OSR2/DKK1/HOXC10/TBX5/TBX3/GREM1/GDF5 | 27 |
| 74 | GO:0003151 | GO:0003151 | outflow tract morphogenesis | 18/700 | 82/18614 | 1.11856949310649e-09 | 7.29186383073747e-08 | 5.30007820986875e-08 | TGFB2/TGFBR2/WNT5A/PITX2/HAND2/FOXC1/TWIST1/ELN/SEMA3C/FZD1/ZFPM2/ENG/NRP1/PARVA/TBX3/SIX1/FOXC2/GATA6 | 18 |
| 75 | GO:0002062 | GO:0002062 | chondrocyte differentiation | 21/700 | 113/18614 | 1.21215601161316e-09 | 7.79658746669582e-08 | 5.66693568376621e-08 | ECM1/EFEMP1/COL3A1/RARB/TGFBR2/TGFBI/RUNX2/SCIN/HOXA11/LOXL2/SNAI2/SULF1/GDF6/OSR2/LTBP3/WNT5B/PTHLH/ACVRL1/GREM1/GDF5/TGFB1 | 21 |
| 76 | GO:1905330 | GO:1905330 | regulation of morphogenesis of an epithelium | 16/700 | 65/18614 | 1.56805501435791e-09 | 9.95302288060861e-08 | 7.23433691527173e-08 | AGT/LBX2/PAX8/WNT5A/GDNF/FGF1/HGF/WNT2/SNAI2/SULF1/WNT5B/NTN4/SIX1/GREM1/FGF7/HOXB7 | 16 |
| 77 | GO:0003206 | GO:0003206 | cardiac chamber morphogenesis | 22/700 | 126/18614 | 1.68384854145358e-09 | 1.0469771100082e-07 | 7.609934436234e-08 | TGFB2/FHL2/TGFBR2/WNT5A/HEG1/SLIT2/HAND2/SLIT3/FOXC1/SEMA3C/FZD1/WNT2/ZFPM2/ENG/NRP1/PARVA/TBX5/TBX3/FOXC2/GATA6/TGFB1/ADAMTS1 | 22 |
| 78 | GO:0035051 | GO:0035051 | cardiocyte differentiation | 25/700 | 161/18614 | 1.69287343658042e-09 | 1.0469771100082e-07 | 7.609934436234e-08 | LMNA/RGS4/TGFB2/AGT/FHL2/RARB/PDGFRA/PITX2/HAND2/MIR145/PDGFRB/SGCD/PI16/TBX18/GPER1/TWIST1/INHBA/SEMA3C/DKK1/TBX5/TBX3/GREM1/GATA6/ALPK2/TGFB1 | 25 |
| 79 | GO:0045926 | GO:0045926 | negative regulation of growth | 32/700 | 252/18614 | 1.75521355767972e-09 | 1.07179116484139e-07 | 7.79029495087428e-08 | CDKN2C/RGS4/KCNK2/TGFB2/AGT/IGFBP5/SERPINE2/TGFBR2/WNT5A/MSX1/SLIT2/DAB2/SLIT3/CDKN1A/PI16/INHBA/SEMA3C/CDKN2A/NRP1/CRYAB/ACVRL1/TBX5/BDKRB1/MEG3/GREM1/SEMA7A/MT2A/MT1E/MT1M/OSGIN1/TGFB1/MAPK11 | 32 |
| 80 | GO:0032965 | GO:0032965 | regulation of collagen biosynthetic process | 13/700 | 41/18614 | 1.79454667041411e-09 | 1.08211164225971e-07 | 7.86530915677553e-08 | EMILIN1/MIR145/PDGFRB/IL6/INHBA/MIR29A/ENG/VIM/CREB3L1/RGCC/TGFB3/TGFB1/RUNX1 | 13 |
| 81 | GO:0007160 | GO:0007160 | cell-matrix adhesion | 31/700 | 239/18614 | 1.87422445558794e-09 | 1.11620478688348e-07 | 8.11311456993296e-08 | COL16A1/CSF1/ITGA10/S100A10/EMILIN1/HOXD3/COL3A1/FN1/SNED1/BST1/SERPINE1/DLC1/ADAM9/CDKN2A/ECM2/NRP1/CD44/EFEMP2/ACVRL1/ITGA5/THSD1/MMP14/NID2/FBLN5/GREM1/THBS1/ITGA11/CDH11/CDH13/RIN2/COL5A3 | 31 |
| 82 | GO:0001704 | GO:0001704 | formation of primary germ layer | 22/700 | 127/18614 | 1.96582804413723e-09 | 1.14254873312265e-07 | 8.30459507295004e-08 | WLS/ATOH8/COL5A2/FN1/WNT5A/COL8A1/MIR145/DUSP1/FOXC1/COL12A1/HOXA11/INHBA/KLF4/COL5A1/DKK1/MMP8/ITGA5/MMP14/MMP2/FOXC2/GATA6/COL6A1 | 22 |
| 83 | GO:0090288 | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 22/700 | 127/18614 | 1.96582804413723e-09 | 1.14254873312265e-07 | 8.30459507295004e-08 | NBL1/AGT/GREM2/EMILIN1/CRIM1/TNFAIP6/GPC1/PPARG/WNT5A/HTRA3/SLIT2/BMPER/FZD1/SULF1/DKK1/HTRA1/CREB3L1/DCN/GREM1/THBS1/FBN1/FSTL3 | 22 |
| 84 | GO:0010718 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 15/700 | 58/18614 | 2.42341556596574e-09 | 1.39173293931175e-07 | 1.01157860278595e-07 | TGFB2/TGFBR2/DAB2/FOXC1/TWIST1/IL6/LOXL2/ZNF703/GLIPR2/ENG/RGCC/TGFB3/TGFB1I1/COL1A1/TGFB1 | 15 |
| 85 | GO:2000027 | GO:2000027 | regulation of animal organ morphogenesis | 22/700 | 129/18614 | 2.66632922270115e-09 | 1.51322025533063e-07 | 1.09988144158731e-07 | CSF1/AGT/PAX8/WNT5A/MSX1/GDNF/DAB2/FGF1/RUNX2/HOXA11/HGF/FZD1/WNT2/SNAI2/SULF1/CTHRC1/DKK1/NTN4/SIX1/GREM1/FGF7/HOXB7 | 22 |
| 86 | GO:0090101 | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 25/700 | 169/18614 | 4.7259956422759e-09 | 2.65095383469057e-07 | 1.92684106296463e-07 | NBL1/GREM2/EMILIN1/LTBP1/CRIM1/TNFAIP6/PPARG/WNT5A/HTRA3/FBN2/CD109/BMPER/FZD1/CAV2/CAV1/ASPN/DKK1/HTRA1/FAM89B/TGFB3/GREM1/FBN1/VASN/TGFB1I1/FSTL3 | 25 |
| 87 | GO:0010755 | GO:0010755 | regulation of plasminogen activation | 9/700 | 18/18614 | 5.12663961092913e-09 | 2.84263327392208e-07 | 2.06616292123472e-07 | S100A10/SERPINE2/SERPINE1/PLAT/THBS1/ANXA2/CTSZ/PLAUR/RUNX1 | 9 |
| 88 | GO:0031638 | GO:0031638 | zymogen activation | 15/700 | 63/18614 | 8.35197148584559e-09 | 4.5269562300808e-07 | 3.29041005551173e-07 | S100A10/IFI16/SERPINE2/SERPINE1/PLAT/PRSS3/CTSL/C1R/MMP14/THBS1/ANXA2/THBD/CTSZ/PLAUR/RUNX1 | 15 |
| 89 | GO:0060393 | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation | 15/700 | 63/18614 | 8.35197148584559e-09 | 4.5269562300808e-07 | 3.29041005551173e-07 | TGFB2/EMILIN1/PPARG/TGFBR2/DAB2/BMPER/INHBA/GDF6/ENG/DKK1/ACVRL1/TGFB3/GREM1/GDF5/TGFB1 | 15 |
| 90 | GO:0035272 | GO:0035272 | exocrine system development | 13/700 | 46/18614 | 8.71175650156505e-09 | 4.66950148483887e-07 | 3.39401881949862e-07 | WLS/TGFB2/FOXC1/SEMA3C/HGF/SNAI2/NRP1/IGF2/NTN4/TGFB3/FGF7/TGM2/TGFB1 | 13 |
| 91 | GO:0061035 | GO:0061035 | regulation of cartilage development | 16/700 | 73/18614 | 9.6357541755109e-09 | 5.108008587106e-07 | 3.71274692407482e-07 | CTSK/EFEMP1/RARB/WNT5A/RUNX2/SCIN/HOXA11/BMP1/LOXL2/SNAI2/GDF6/LTBP3/PTHLH/ACVRL1/GREM1/GDF5 | 16 |
| 92 | GO:0050680 | GO:0050680 | negative regulation of epithelial cell proliferation | 25/700 | 177/18614 | 1.23590163653289e-08 | 6.48042336373333e-07 | 4.71028415479526e-07 | TGFB2/ATOH8/LIMS2/PPARG/WNT5A/DAB2/SPARC/CD109/CAV2/CAV1/SNAI2/SULF1/CDKN2B/B4GALT1/KLF9/ZEB1/VDR/ACVRL1/RGCC/THBS1/B2M/NUPR1/CCL2/GDF5/TGFB1 | 25 |
| 93 | GO:0003205 | GO:0003205 | cardiac chamber development | 24/700 | 166/18614 | 1.51913697548176e-08 | 7.87991050507957e-07 | 5.72749888548923e-07 | KCNK2/TGFB2/FHL2/PAX8/TGFBR2/WNT5A/HEG1/SLIT2/HAND2/SLIT3/FOXC1/SEMA3C/FZD1/WNT2/ZFPM2/ENG/NRP1/PARVA/TBX5/TBX3/FOXC2/GATA6/TGFB1/ADAMTS1 | 24 |
| 94 | GO:0035987 | GO:0035987 | endodermal cell differentiation | 13/700 | 48/18614 | 1.5407671913936e-08 | 7.9070860971093e-07 | 5.74725141604937e-07 | COL5A2/FN1/COL8A1/COL12A1/INHBA/COL5A1/DKK1/MMP8/ITGA5/MMP14/MMP2/GATA6/COL6A1 | 13 |
| 95 | GO:0072001 | GO:0072001 | renal system development | 35/700 | 320/18614 | 1.60351317562482e-08 | 8.14247111496227e-07 | 5.91834059612885e-07 | NFIA/TGFB2/AGT/KIF26B/PAX8/RARB/WNT5A/MME/SLIT2/PDGFRA/GDNF/FOXD1/FGF1/PDGFRB/FOXC1/TBX18/HOXA11/BMPER/SULF1/GDF6/OSR2/ANGPT1/HAS2/NRP1/BICC1/ARID5B/ACTA2/KIRREL3/SIX1/GREM1/FBN1/FOXC2/HOXB7/WNT7B/ADAMTS1 | 35 |
| 96 | GO:0001706 | GO:0001706 | endoderm formation | 14/700 | 57/18614 | 1.70843095414902e-08 | 8.58486554459881e-07 | 6.23989419766488e-07 | COL5A2/FN1/COL8A1/DUSP1/COL12A1/INHBA/COL5A1/DKK1/MMP8/ITGA5/MMP14/MMP2/GATA6/COL6A1 | 14 |
| 97 | GO:0060389 | GO:0060389 | pathway-restricted SMAD protein phosphorylation | 15/700 | 67/18614 | 2.05608476281236e-08 | 1.02253122637184e-06 | 7.4322499673662e-07 | TGFB2/EMILIN1/PPARG/TGFBR2/DAB2/BMPER/INHBA/GDF6/ENG/DKK1/ACVRL1/TGFB3/GREM1/GDF5/TGFB1 | 15 |
| 98 | GO:0048754 | GO:0048754 | branching morphogenesis of an epithelial tube | 23/700 | 157/18614 | 2.35031867059966e-08 | 1.15693237418089e-06 | 8.40914231124324e-07 | CSF1/AGT/PAX8/TGFBR2/WNT5A/SLIT2/HHIP/GDNF/FOXD1/FGF1/HOXA5/HOXA11/WNT2/ENG/NRP1/VDR/TBX3/MMP14/SIX1/GREM1/FOXC2/HOXB7/CTSZ | 23 |
| 99 | GO:0010632 | GO:0010632 | regulation of epithelial cell migration | 33/700 | 295/18614 | 2.39004060461705e-08 | 1.16460160370431e-06 | 8.46488596914343e-07 | PTGS2/TGFB2/AGT/PRKCE/ATOH8/SP100/PPARG/TGFBR2/WNT5A/GATA2/SLIT2/VEGFC/FGF1/SPARC/MEOX2/BMPER/MIR29A/ADAM9/ANGPT1/ENPP2/HAS2/GLIPR2/ANXA1/KLF4/NRP1/ACVRL1/DCN/RGCC/THBS1/FGF7/FOXC2/RIN2/TGFB1 | 33 |
| 100 | GO:0010717 | GO:0010717 | regulation of epithelial to mesenchymal transition | 19/700 | 110/18614 | 2.60239895153838e-08 | 1.25539725422212e-06 | 9.1248325342888e-07 | TGFB2/TGFBR2/DAB2/MIR145/FOXC1/TWIST1/IL6/LOXL2/ZNF703/GLIPR2/ENG/TBX5/RGCC/TGFB3/GREM1/VASN/TGFB1I1/COL1A1/TGFB1 | 19 |