--- a
+++ b/tests/test_disease.py
@@ -0,0 +1,88 @@
+from openomics.database.disease import DisGeNet, LncRNADisease, HMDD, MalaCards
+
+from .test_multiomics import *
+
+
+@pytest.fixture
+def generate_DisGeNet_ftp():
+    return DisGeNet(path="https://www.disgenet.org/static/disgenet_ap1/files/downloads/", curated=True)
+
+
+@pytest.fixture
+def generate_LncRNADisease_ftp():
+    return LncRNADisease(path="http://www.cuilab.cn/files/images/ldd/", species="Human")
+
+
+@pytest.fixture
+def generate_HMDD_ftp():
+    return HMDD(path="http://www.cuilab.cn/static/hmdd3/data/")
+
+
+@pytest.fixture
+def generate_MalaCards_ftp():
+    return MalaCards()
+
+
+def test_import_DisGeNet(generate_DisGeNet_ftp):
+    """
+    Args:
+        generate_DisGeNet_ftp:
+    """
+    assert generate_DisGeNet_ftp.data_path == "https://www.disgenet.org/static/disgenet_ap1/files/downloads/"
+    assert not generate_DisGeNet_ftp.get_disease_assocs(index="gene_name").empty
+
+
+def test_annotate_DisGeNet(generate_TCGA_LUAD, generate_DisGeNet_ftp):
+    """
+    Args:
+        generate_TCGA_LUAD:
+        generate_DisGeNet_ftp:
+    """
+    generate_TCGA_LUAD.MessengerRNA.annotate_diseases(generate_DisGeNet_ftp, on="gene_name", )
+    assert {'disease_associations'}.issubset(generate_TCGA_LUAD.MessengerRNA.annotations.columns)
+
+
+def test_import_HMDD(generate_HMDD_ftp):
+    """
+    Args:
+        generate_HMDD_ftp:
+    """
+    assert generate_HMDD_ftp.data_path == "http://www.cuilab.cn/static/hmdd3/data/"
+    assert not generate_HMDD_ftp.get_disease_assocs(index="gene_name").empty
+
+
+def test_annotate_HMDD(generate_TCGA_LUAD, generate_HMDD_ftp):
+    """
+    Args:
+        generate_TCGA_LUAD:
+        generate_HMDD_ftp:
+    """
+    generate_TCGA_LUAD.MicroRNA.annotate_diseases(generate_HMDD_ftp, on="gene_name", )
+    assert {'disease_associations'}.issubset(generate_TCGA_LUAD.MicroRNA.annotations.columns)
+
+
+def test_LncRNADisease(generate_LncRNADisease_ftp):
+    """
+    Args:
+        generate_LncRNADisease_ftp:
+    """
+    assert generate_LncRNADisease_ftp.data_path == "http://www.cuilab.cn/files/images/ldd/"
+    assert not generate_LncRNADisease_ftp.get_disease_assocs(index="gene_name").empty
+
+
+def test_annotate_LncRNADisease(generate_TCGA_LUAD, generate_LncRNADisease_ftp):
+    """
+    Args:
+        generate_TCGA_LUAD:
+        generate_LncRNADisease_ftp:
+    """
+    generate_TCGA_LUAD.LncRNA.annotate_diseases(generate_LncRNADisease_ftp, on="gene_name", )
+    assert {'disease_associations'}.issubset(generate_TCGA_LUAD.LncRNA.annotations.columns)
+
+
+def test_import_MalaCards(generate_MalaCards_ftp):
+    """
+    Args:
+        generate_MalaCards_ftp:
+    """
+    assert generate_MalaCards_ftp.data_path == "http://zdzlab.einstein.yu.edu/1/hedd/"