--- a
+++ b/OmicsFold/man/normalise.tss.Rd
@@ -0,0 +1,30 @@
+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/MixMC.R
+\name{normalise.tss}
+\alias{normalise.tss}
+\title{Apply Total Sum Scaling normalisation}
+\usage{
+normalise.tss(otu.counts, offset = 0)
+}
+\arguments{
+\item{otu.counts}{OTU count data frame of size n (sample) x p (OTU).}
+
+\item{offset}{Offset to apply, defaulting to zero.}
+}
+\value{
+Data frame containing count data normalised as proportion of total
+sample counts.
+}
+\description{
+Apply Total Sum Scaling (TSS) normalisation to count data, to account for
+differences in count (e.g. sequencing) depths between samples. Giving
+proportion of total sample counts, this is the conventional way of
+normalising OTU count data. Optionally include an offset to avoid
+division/log zero problems - this defaults to zero, but 1 (count) is usually
+appropriate for any count data with totals of thousands of counts or more.
+}
+\examples{
+\dontrun{
+normalise.tss(otu.count, offset=1)
+}
+}