--- a
+++ b/README.md
@@ -0,0 +1,10 @@
+# Multi-omic Landscape of Airway Microbe-Host Interaction in Chronic Obstructive Pulmonary Disease
+
+This repository contains data and computer codes for main bioinformatic analyses of the manuscript (Yan et al. 2022, Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions, In Press, Nature Microbiology).
+
+- 1-Metagenome, which contains the commands and scripts to process metagenomic data to generate taxonomic and functional profiles for this study. 
+- 2-Transcriptome, which contains the commands and scripts to process host transcriptomic to generate gene expression table for this study.
+- 3-Metabolome and Proteome, which describes the processes to generate metabolomic data and sputum and serum proteomic data for this study.
+- 4-Multi-omic Integration, which contains the original scripts and datasets for downstream multi-omic data analyses for this study.
+- 5-Datasets, which contains clinical metadata table and the processed (original and dimensionality reduced) multi-omic data tables.
+- 6-Figure scripts, which contains the scripts and datasets for the main and supplementary figures for this study.