Datasets
Models
Diff of
/inst/templates/H.C2CP.genesets.gmt
[000000]
..
[2ab972]
Switch to side-by-side view
--- a +++ b/inst/templates/H.C2CP.genesets.gmt @@ -0,0 +1,1378 @@ +HALLMARK_ADIPOGENESIS Genes up-regulated during adipocyte differentiation (adipogenesis). ABCA1 ABCB8 ACAA2 ACADL ACADM ACADS ACLY ACO2 ACOX1 ADCY6 ADIG ADIPOQ ADIPOR2 AGPAT3 AGPAT6 AIFM1 AK2 ALDH2 ALDOA ANGPT1 ANGPTL4 ANKRD57 APLP2 APOE ARAF ARL4A ATL2 ATP1B3 ATP5O BAZ2A BCKDHA BCL2L13 BCL6 C3 CAT CCNG2 CD151 CD302 CD36 CDKN2C CHCHD10 CHUK CIDEA CMBL CMPK1 COL15A1 COL4A1 COQ3 COQ5 COQ9 COX6A1 COX7B COX8A CPT2 CRAT CS CYC1 CYP4B1 DBT DDT DECR1 DGAT1 DHCR7 DHRS7 DHRS7B DLAT DLD DNAJB9 DNAJC15 DRAM2 ECH1 ECHS1 ELMOD3 ELOVL6 ENPP2 EPHX2 ESRRA ESYT1 ETFB FABP4 FAH FAM73B FAM82A2 FZD4 G3BP2 GADD45A GBE1 GHITM GPAM GPD2 GPHN GPX3 GPX4 GRPEL1 HADH HIBCH HSPB8 IDH1 IDH3A IDH3G IFNGR1 IMMT ITGA7 ITIH5 ITSN1 JAGN1 LAMA4 LEP LIFR LIPE LPCAT3 LPL LTC4S MAP4K3 MCCC1 MDH2 ME1 MGLL MGST3 MOSC2 MRAP MRPL15 MTCH2 MYLK NDUFA5 NDUFAB1 NDUFB7 NDUFS3 NKIRAS1 NMT1 OBFC2A OMD ORM1 PDCD4 PEMT PEX14 PFKFB3 PFKL PGM1 PHLDB1 PHYH PIM3 PLIN2 POR PPARG PPM1B PPP1R15B PQLC3 PRDX3 PREB PTCD3 PTGER3 PTRF QDPR RAB34 REEP5 REEP6 RETN RETSAT RIOK3 RNF11 RREB1 RTN3 SAMM50 SCARB1 SCP2 SDHB SDHC SDPR SLC19A1 SLC1A5 SLC25A1 SLC25A10 SLC27A1 SLC5A6 SNCG SOD1 SORBS1 SPARCL1 SQRDL SSPN STAT5A STOM SUCLG1 SULT1A1 TALDO1 TANK TKT TOB1 TST UBC UBQLN1 UCK1 UCP2 UQCR10 UQCR11 UQCRC1 UQCRQ VEGFB YWHAG +HALLMARK_ALLOGRAFT_REJECTION Genes up-regulated during transplant rejection. AARS ABCE1 ABI1 ACHE ACVR2A AKT1 APBB1 B2M BCAT1 BCL10 BCL3 BRCA1 C2 CAPG CARTPT CCL11 CCL13 CCL19 CCL2 CCL22 CCL4 CCL5 CCL7 CCND2 CCND3 CCR1 CCR2 CCR5 CD1D CD2 CD247 CD28 CD3D CD3E CD3G CD4 CD40 CD40LG CD47 CD7 CD74 CD79A CD80 CD86 CD8A CD8B CD96 CDKN2A CFP CRTAM CSF1 CSK CTSS CXCL13 CXCL9 CXCR3 DARS DEGS1 DYRK3 EGFR EIF3A EIF3D EIF3J EIF4G3 EIF5A ELANE ELF4 EREG ETS1 F2 F2R FAS FASLG FCGR2B FGR FLNA FYB GALNT1 GBP2 GCNT1 GLMN GPR65 GZMA GZMB HCLS1 HDAC9 HIF1A HLA-A HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DQA1 HLA-DRA HLA-E HLA-G ICAM1 ICOSLG IFNAR2 IFNG IFNGR1 IFNGR2 IGSF6 IKBKB IL10 IL11 IL12A IL12B IL12RB1 IL13 IL15 IL16 IL18 IL18RAP IL1B IL2 IL27RA IL2RA IL2RB IL2RG IL4 IL4R IL6 IL7 IL9 INHBA INHBB IRF4 IRF7 IRF8 ITGAL ITGB2 ITK JAK2 KLRD1 KRT1 LCK LCP2 LIF LTB LY75 LY86 LYN MAP3K7 MAP4K1 MBL2 MMP9 MRPL3 MTIF2 NCF4 NCK1 NCR1 NLRP3 NME1 NOS2 NPM1 PF4 PRF1 PRKCB PRKCG PSMB10 PTPN6 PTPRC RARS RIPK2 RPL39 RPL3L RPL9 RPS19 RPS3A RPS9 SIT1 SOCS1 SOCS5 SPI1 SRGN ST8SIA4 STAB1 STAT1 STAT4 TAP1 TAP2 TAPBP TGFB1 TGFB2 THY1 TIMP1 TLR1 TLR2 TLR3 TLR6 TNF TPD52 TRAF2 TRAT1 UBE2D1 UBE2N WARS WAS ZAP70 +HALLMARK_ANDROGEN_RESPONSE Genes defining response to androgens. ABCC4 ABHD2 ACSL3 ACTN1 ADAMTS1 ADRM1 AKAP12 AKT1 ALDH1A3 ANKH APPBP2 ARID5B AZGP1 B2M B4GALT1 BMPR1B CAMKK2 CCND1 CCND3 CDC14B CDK6 CENPN DBI DHCR24 DNAJB9 ELK4 ELL2 ELOVL5 FADS1 FKBP5 GNAI3 GPD1L GSR GUCY1A3 H1F0 HERC3 HMGCR HMGCS1 HOMER2 HPGD HSD17B14 IDI1 INPP4B INSIG1 IQGAP2 ITGAV KLK2 KLK3 KRT19 KRT8 LIFR LMAN1 MAF MAK MAP7 MERTK MYL12A NCOA4 NDRG1 NGLY1 NKX3-1 PA2G4 PDLIM5 PGM3 PIAS1 PMEPA1 PPAP2A PTK2B PTPN21 RAB4A RPS6KA3 RRP12 SAT1 SCD SEC24D SEPP1 SGK1 SLC26A2 SLC38A2 SMS SORD SPCS3 SPDEF SRF SRP19 STEAP4 STK39 TARP TMEM50A TMPRSS2 TNFAIP8 TPD52 TSC22D1 UAP1 UBE2I UBE2J1 VAPA XRCC5 XRCC6 ZBTB10 ZMIZ1 +HALLMARK_ANGIOGENESIS Genes up-regulated during formation of blood vessels (angiogenesis). APOH APP CCND2 COL3A1 COL5A2 CXCL6 FGFR1 FSTL1 ITGAV JAG1 JAG2 KCNJ8 LPL LRPAP1 LUM MSX1 NRP1 OLR1 PDGFA PF4 PGLYRP1 POSTN PRG2 PTK2 S100A4 SERPINA5 SLCO2A1 SPP1 STC1 THBD TIMP1 TNFRSF21 VAV2 VCAN VEGFA VTN +HALLMARK_APICAL_JUNCTION Genes encoding components of apical junction complex. ACTA1 ACTB ACTC1 ACTG1 ACTG2 ACTN1 ACTN2 ACTN3 ACTN4 ADAM15 ADAM23 ADAM9 ADAMTS5 ADRA1B AKT2 AKT3 ALOX15B AMH AMIGO1 AMIGO2 ARHGEF6 ARPC2 ATP1A3 B4GALT1 BAIAP2 BMP1 CADM2 CADM3 CALB2 CAP1 CD209 CD274 CD276 CD34 CD86 CD99 CDH1 CDH11 CDH15 CDH3 CDH4 CDH6 CDH8 CDK8 CDSN CERCAM CLDN11 CLDN14 CLDN15 CLDN18 CLDN19 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CNN2 CNTN1 COL16A1 COL17A1 COL9A1 CRAT CRB3 CTNNA1 CTNND1 CX3CL1 DHX16 DLG1 DMP1 DSC1 DSC3 EGFR EPB41L2 EVL EXOC4 FBN1 FLNC FSCN1 FYB GAMT GNAI1 GNAI2 GRB7 GTF2F1 HADH HRAS ICAM1 ICAM2 ICAM4 ICAM5 IKBKG INPPL1 INSIG1 IRS1 ITGA10 ITGA2 ITGA3 ITGA9 ITGB1 ITGB4 JAM3 JUP KCNH2 KRT31 LAMA3 LAMB3 LAMC2 LAYN LDLRAP1 LIMA1 MADCAM1 MAP4K2 MAPK11 MAPK13 MAPK14 MDK MMP2 MMP9 MPP5 MPZL1 MPZL2 MSN MVD MYH10 MYH9 MYL12B MYL9 NEGR1 NEXN NF1 NF2 NFASC NLGN2 NLGN3 NRAP NRTN NRXN2 PARD6G PARVA PBX2 PCDH1 PDZD3 PECAM1 PFN1 PIK3CB PIK3R3 PKD1 PLCG1 PPP2R2C PTEN PTK2 PTPRC PVRL1 PVRL2 PVRL3 PVRL4 RAC2 RASA1 RHOF RRAS RSU1 SDC3 SGCE SHC1 SHROOM2 SIRPA SKAP2 SLC30A3 SLIT2 SORBS3 SPEG SRC STX4 SYK SYMPK TAOK2 TGFBI THBS3 THY1 TIAL1 TJP1 TMEM8B TNFRSF11B TRAF1 TRO TSC1 TSPAN4 TUBG1 VASP VAV2 VCAM1 VCAN VCL VWF WASL WNK4 YWHAH ZAK ZYX +HALLMARK_APICAL_SURFACE Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area). ADAM10 ADIPOR2 AFAP1L2 AIM1 AKAP7 APP ATP6V0A4 ATP8B1 B4GALT1 BRCA1 CD160 CROCC CX3CL1 DCBLD2 EFNA5 EPHB4 FLOT2 GAS1 GATA3 GHRL GSTM3 HSPB1 IL2RB IL2RG LYN LYPD3 MAL MDGA1 NCOA6 NTNG1 PCSK9 PKHD1 PLAUR RHCG RTN4RL1 SCUBE1 SHROOM2 SLC22A12 SLC2A4 SLC34A3 SRPX SULF2 THY1 TMEM8B +HALLMARK_APOPTOSIS Genes mediating programmed cell death (apoptosis) by activation of caspases. ADD1 AIFM3 ANKH ANXA1 APP ATF3 AVPR1A BAX BCAP31 BCL10 BCL2L1 BCL2L10 BCL2L11 BCL2L2 BGN BID BIK BIRC3 BMF BMP2 BNIP3L BRCA1 BTG2 BTG3 CASP1 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CAV1 CCNA1 CCND1 CCND2 CD14 CD2 CD38 CD44 CD69 CDC25B CDK2 CDKN1A CDKN1B CFLAR CLU CREBBP CTH CTNNB1 CYLD DAP DAP3 DCN DDIT3 DFFA DIABLO DNAJA1 DNAJC3 DNM1L DPYD EBP EGR3 EMP1 ENO2 ERBB2 ERBB3 EREG ETF1 F2 F2R FAS FASLG FDXR FEZ1 GADD45A GADD45B GCH1 GNA15 GPX1 GPX3 GPX4 GSN GSR GSTM1 GUCY2D H1F0 HGF HMGB2 HMOX1 HSPB1 IER3 IFITM3 IFNB1 IFNGR1 IGF2R IGFBP6 IL18 IL1A IL1B IL6 IRF1 ISG20 JUN KRT18 LEF1 LGALS3 LMNA LPPR4 LUM MADD MCL1 MGMT MMP2 NEDD9 NEFH PAK1 PDCD4 PDGFRB PEA15 PLAT PLCB2 PMAIP1 PPP2R5B PPP3R1 PPT1 PRF1 PSEN1 PSEN2 PTK2 RARA RELA RETSAT RHOB RHOT2 RNASEL ROCK1 SAT1 SATB1 SC5DL SLC20A1 SMAD7 SOD1 SOD2 SPTAN1 SQSTM1 TAP1 TGFB2 TGFBR3 TIMP1 TIMP2 TIMP3 TNF TNFRSF12A TNFSF10 TOP2A TSPO TXNIP VDAC2 WEE1 XIAP +HALLMARK_BILE_ACID_METABOLISM Genes involve in metabolism of bile acids and salts. ABCA1 ABCA2 ABCA3 ABCA4 ABCA5 ABCA6 ABCA8 ABCA9 ABCD1 ABCD2 ABCD3 ABCG4 ABCG8 ACSL1 ACSL5 AGXT AKR1D1 ALDH1A1 ALDH8A1 ALDH9A1 AMACR APOA1 AQP9 AR ATXN1 BBOX1 BCAR3 BMP6 CAT CH25H CROT CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 DHCR24 DIO1 DIO2 EFHC1 EPHX2 FADS1 FADS2 FDXR GC GCLM GNMT GNPAT GSTK1 HACL1 HAO1 HSD17B11 HSD17B4 HSD17B6 HSD3B1 HSD3B7 IDH1 IDH2 IDI1 ISOC1 KLF1 LCK LIPE LONP2 MLYCD NEDD4 NPC1 NR0B2 NR1H4 NR1I2 NR3C2 NUDT12 OPTN PAOX PECR PEX1 PEX11A PEX11G PEX12 PEX13 PEX16 PEX19 PEX26 PEX6 PEX7 PFKM PHYH PIPOX PNPLA8 PRDX5 PXMP2 RBP1 RETSAT RXRA RXRG SCP2 SERPINA6 SLC22A18 SLC23A1 SLC23A2 SLC27A2 SLC27A5 SLC29A1 SLC35B2 SLCO1A2 SOAT2 SOD1 SULT1B1 SULT2B1 TFCP2L1 TTR +HALLMARK_CHOLESTEROL_HOMEOSTASIS Genes involved in cholesterol homeostasis. ABCA2 ACAT2 ACSS2 ACTG1 ADH4 ALCAM ALDOC ANTXR2 ANXA13 ANXA5 ATF3 ATF5 ATXN2 AVPR1A CBS CD9 CHKA CLU CPEB2 CTNNB1 CXCL16 CYP51A1 DHCR7 EBP ECH1 ERRFI1 ETHE1 FABP5 FADS2 FAM129A FASN FBXO6 FDFT1 FDPS GLDC GNAI1 GPX8 GSTM2 GUSB HMGCR HMGCS1 HSD17B7 IDI1 JAG1 LDLR LGALS3 LGMN LPL LSS MAL2 MVD MVK NFIL3 NSDHL PCYT2 PDK3 PLAUR PLSCR1 PMVK PNRC1 PPARG S100A11 SC5DL SCD SEMA3B SQLE SREBF2 STARD4 STX5 TM7SF2 TMEM97 TNFRSF12A TP53INP1 TRIB3 +HALLMARK_COAGULATION Genes encoding components of blood coagulation system; also up-regulated in platelets. A2M ACOX2 ADAM9 ANG ANXA1 APOA1 APOC1 APOC2 APOC3 ARF4 BMP1 C1QA C1R C1S C2 C3 C8A C8B C8G C9 CAPN2 CAPN5 CASP9 CD9 CFB CFD CFH CFI CLU COMP CPB2 CPN1 CRIP2 CSRP1 CTSB CTSE CTSH CTSK CTSL2 CTSO DCT DPP4 DUSP14 DUSP6 F10 F11 F12 F13B F2 F2RL2 F3 F8 F9 FBN1 FGA FGG FN1 FURIN FYN GDA GNB2 GNG12 GP1BA GP9 GSN HMGCS2 HNF4A HPN HRG HTRA1 ISCU ITGA2 ITGB3 ITIH1 KLF7 KLK8 KLKB1 LAMP2 LEFTY2 LGMN LRP1 LTA4H MAFF MASP2 MBL2 MEP1A MMP1 MMP10 MMP11 MMP14 MMP15 MMP2 MMP3 MMP7 MMP8 MMP9 MSRB2 MST1 OLR1 P2RY1 PDGFB PECAM1 PEF1 PF4 PGCP PLAT PLAU PLEK PLG PREP PROC PROS1 PROZ PRSS23 RABIF RAC1 RAPGEF3 RGN S100A1 S100A13 SERPINA1 SERPINB2 SERPINC1 SERPINE1 SERPING1 SH2B2 SIRT2 SPARC TF TFPI2 THBD THBS1 TIMP1 TIMP3 TMPRSS6 USP11 VWF WDR1 +HALLMARK_COMPLEMENT Genes encoding components of the complement system, which is part of the innate immune system. ACTN2 ADAM9 ADRA2B AKAP10 ANG ANXA5 APOA4 APOBEC3F APOBEC3G APOC1 ATOX1 BRPF3 C1QA C1QC C1R C1S C2 C3 C4BPB C9 CA2 CALM1 CALM3 CASP1 CASP10 CASP3 CASP4 CASP5 CASP7 CASP9 CBLB CCL5 CD36 CD40LG CD46 CD55 CD59 CDA CDH13 CDK5R1 CEBPB CFB CFH CLU COL4A2 CP CPM CR1 CR2 CSRP1 CTSB CTSC CTSD CTSH CTSL1 CTSL2 CTSO CTSS CXCL1 DGKG DGKH DOCK10 DOCK4 DOCK9 DPP4 DUSP5 DUSP6 DYRK2 EHD1 ERAP2 F10 F2 F3 F5 F7 F8 FCER1G FCN1 FDX1 FN1 FYN GATA3 GCA GMFB GNAI2 GNAI3 GNB2 GNB4 GNG2 GNGT2 GP1BA GP9 GPD2 GRB2 GZMA GZMB GZMK HNF4A HPCAL4 HSPA1A HSPA5 IL6 IRF1 IRF2 IRF7 ITGAM ITIH1 JAK2 KCNIP2 KCNIP3 KIF2A KLK1 KLKB1 KYNU L3MBTL4 LAMP2 LAP3 LCK LCP2 LGALS3 LGMN LIPA LRP1 LTA4H LTF LYN MAFF ME1 MMP12 MMP13 MMP14 MMP15 MMP8 MT3 NOTCH4 OLR1 PCLO PCSK9 PDGFB PDP1 PFN1 PGCP PHEX PIK3CA PIK3CG PIK3R5 PIM1 PLA2G4A PLA2G7 PLAT PLAUR PLEK PLG PLSCR1 PPP2CB PPP4C PRCP PRDM4 PREP PRKCD PRSS3 PRSS36 PSEN1 PSMB9 RABIF RAF1 RASGRP1 RCE1 RHOG RNF4 S100A12 S100A13 S100A9 SCG3 SEPX1 SERPINA1 SERPINB2 SERPINC1 SERPINE1 SERPING1 SH2B3 SIRT6 SPOCK2 SRC STX4 TFPI2 TIMP1 TIMP2 TMPRSS6 TNFAIP3 USP14 USP15 USP16 USP8 VCPIP1 WAS XPNPEP1 ZEB1 ZFPM2 ZFYVE20 +HALLMARK_DNA_REPAIR Genes involved in DNA repair. AAAS ADA ADCY6 ADRM1 AK1 AK3 APRT ARL6IP1 BCAM BCAP31 BOLA2 BRF2 BRP44 CANT1 CCNO CDA CETN2 CLP1 CMPK2 COBRA1 COX17 CSTF3 DAD1 DCTN4 DDB1 DDB2 DFNA5 DGCR8 DGUOK DUT EDF1 EIF1B EIF2C4 ELL ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC8 FEN1 GMPR2 GPX4 GTF2A2 GTF2B GTF2F1 GTF2H1 GTF2H3 GTF2H5 GTF3C5 GUK1 HCLS1 HPRT1 IMPDH2 ITPA LIG1 MPG MRPL40 NCBP2 NFX1 NME1 NME3 NME4 NPR2 NT5C NT5C3 NUDT21 NUDT9 PCNA PDE4B PDE6G PNP POLA1 POLA2 POLB POLD1 POLD3 POLD4 POLE4 POLH POLL POLR1C POLR1D POLR2A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR3C POLR3GL POM121 PRIM1 RAD51 RAD52 RAE1 RALA RBX1 RDBP REV3L RFC2 RFC3 RFC4 RFC5 RNMT RPA2 RPA3 RRM2B SAC3D1 SDCBP SEC61A1 SF3A3 SMAD5 SNAPC4 SNAPC5 SRSF6 SSRP1 STX3 SUPT4H1 SUPT5H SURF1 TAF10 TAF12 TAF13 TAF1C TAF6 TAF9 TARBP2 TCEB3 TH1L THOC4 TK2 TMED2 TP53 TSG101 TYMS UMPS UPF3B USP11 VPS28 VPS37B VPS37D XPC ZNF707 ZNRD1 ZWINT +HALLMARK_E2F_TARGETS Genes encoding cell cycle related targets of E2F transcription factors. AK2 ANP32E ASF1A ASF1B ATAD2 AURKA AURKB BARD1 BIRC5 BRCA1 BRCA2 BRMS1L BUB1B CBX5 CCNB2 CCNE1 CCP110 CDC20 CDC25A CDC25B CDCA3 CDCA8 CDK1 CDK4 CDKN1A CDKN1B CDKN2A CDKN2C CDKN3 CENPE CENPM CHEK1 CHEK2 CIT CKS1B CKS2 CSE1L CTCF CTPS DCK DCLRE1B DCTPP1 DDX39A DEK DEPDC1 DIAPH3 DLGAP5 DNMT1 DONSON DSCC1 DUT E2F8 EED EIF2S1 ESPL1 EXOSC8 EZH2 GINS1 GINS3 GINS4 GSPT1 H2AFX H2AFZ HELLS HMGA1 HMGB2 HMGB3 HMMR HN1 HNRNPD HUS1 ILF3 ING3 IPO7 KIF18B KIF22 KIF2C KIF4A KPNA2 LBR LIG1 LMNB1 LUC7L3 LYAR MAD2L1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MELK MKI67 MLH1 MMS22L MRE11A MSH2 MTHFD2 MXD3 MYBL2 MYC NAA38 NAP1L1 NASP NBN NCAPD2 NME1 NOLC1 NOP56 NUDT21 NUP107 NUP153 NUP205 ORC2 ORC6 PA2G4 PAICS PAN2 PCNA PDS5B PHF5A PLK1 PLK4 PMS2 PNN POLA2 POLD1 POLD2 POLD3 POLE POLE4 POP7 PPM1D PPP1R8 PRDX4 PRIM2 PRKDC PRPS1 PSIP1 PSMC3IP PTTG1 RACGAP1 RAD1 RAD21 RAD50 RAD51AP1 RAD51C RAN RANBP1 RBBP7 RFC1 RFC2 RFC3 RNASEH2A RPA1 RPA2 RPA3 RQCD1 RRM2 SHMT1 SLBP SMC1A SMC3 SMC4 SMC6 SNRPB SPAG5 SPC24 SPC25 SRSF1 SRSF2 SSRP1 STAG1 STMN1 SUV39H1 SYNCRIP TACC3 TBRG4 TCF19 TFRC TIMELESS TIPIN TK1 TMPO TOP2A TP53 TRA2B TRIP13 TUBB TUBG1 UBE2S UBE2T UBR7 UNG USP1 WDR90 WEE1 XPO1 XRCC6 ZW10 +HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. ABI3BP ACTA2 ADAM12 ANPEP APLP1 AREG BASP1 BDNF BGN BMP1 CADM1 CALD1 CALU CAP2 CAPG CD44 CD59 CDH11 CDH2 CDH6 COL11A1 COL12A1 COL16A1 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COL5A1 COL5A2 COL5A3 COL6A2 COL6A3 COL7A1 COL8A2 COMP COPA CRLF1 CTGF CTHRC1 CXCL1 CXCL12 CXCL6 CYR61 DAB2 DCN DKK1 DPYSL3 DST ECM1 ECM2 EDIL3 EFEMP2 ELN EMP3 ENO2 FAP FAS FBLN1 FBLN2 FBLN5 FBN1 FBN2 FERMT2 FGF2 FLNA FMOD FN1 FOXC2 FSTL1 FSTL3 FUCA1 FZD8 GADD45A GADD45B GAS1 GEM GJA1 GLIPR1 GLT25D1 GPC1 GPX7 GREM1 HTRA1 ID2 IGFBP2 IGFBP3 IGFBP4 IL15 IL32 IL6 IL8 INHBA ITGA2 ITGA5 ITGAV ITGB1 ITGB3 ITGB5 JUN LAMA1 LAMA2 LAMA3 LAMC1 LAMC2 LEPRE1 LGALS1 LOX LOXL1 LOXL2 LRP1 LRRC15 LUM MAGEE1 MATN2 MATN3 MCM7 MEST MFAP5 MGP MMP1 MMP14 MMP2 MMP3 MSX1 MXRA5 MYL9 MYLK NID2 NNMT NOTCH2 NT5E NTM OXTR PCOLCE PCOLCE2 PDGFRB PDLIM4 PFN2 PLAUR PLOD1 PLOD2 PLOD3 PMEPA1 PMP22 POSTN PPIB PRRX1 PRSS2 PTHLH PTX3 PVR QSOX1 RGS4 RHOB SAT1 SCG2 SDC1 SDC4 SERPINE1 SERPINE2 SERPINH1 SFRP1 SFRP4 SGCB SGCD SGCG SLC6A8 SLIT2 SLIT3 SNAI2 SNTB1 SPARC SPOCK1 SPP1 TAGLN TFPI2 TGFB1 TGFBI TGFBR3 TGM2 THBS1 THBS2 THY1 TIMP1 TIMP3 TNC TNFAIP3 TNFRSF11B TNFRSF12A TPM1 TPM2 TPM4 VCAM1 VCAN VEGFA VEGFC VIM WIPF1 WNT5A +HALLMARK_ESTROGEN_RESPONSE_EARLY Genes defining early response to estrogen. ABAT ABCA3 ABHD2 ABLIM1 ADCY1 ADCY9 ADD3 AFF1 AKAP1 ALDH3B1 AMFR ANXA9 AQP3 AR AREG ARL3 ASB13 B4GALT1 BAG1 BCL11B BCL2 BHLHE40 BLVRB CA12 CALB2 CALCR CANT1 CBFA2T3 CCND1 CD44 CELSR1 CELSR2 CHPT1 CISH CLDN7 CLIC3 CXCL12 CYP26B1 DEPTOR DHCR7 DHRS2 DHRS3 DLC1 DYNLT3 EGR3 ELF1 ELF3 ELOVL2 ELOVL5 ENDOD1 ESRP2 FAIM3 FAM102A FAM134B FAM63A FARP1 FASN FDFT1 FHL2 FKBP4 FKBP5 FLNB FOS FOXC1 FRK GAB2 GFRA1 GJA1 GLA GREB1 HES1 HR HSPB8 IGF1R IGFBP4 IL17RB IL6ST INHBB INPP5F ISG20L2 ITPK1 JAK2 KAZN KCNK15 KCNK5 KDM4B KLF10 KLF4 KLK10 KRT13 KRT15 KRT18 KRT19 KRT8 LAD1 LRIG1 MAPT MAST4 MED13L MED24 MICB MLPH MPPED2 MREG MSMB MUC1 MYB MYBBP1A MYBL1 MYC MYOF NADSYN1 NAV2 NBL1 NCOR2 NPY1R NRIP1 NXT1 OLFM1 OLFML3 OPN3 OVOL2 P2RY2 PAPSS2 PDLIM3 PDZK1 PEX11A PGR PLA2G16 PMAIP1 PODXL PPIF PRSS23 PTGES RAB17 RAB31 RAPGEFL1 RARA RASGRP1 RBBP8 REEP1 RET RHOBTB3 RHOD RPS6KA2 RRP12 SCARB1 SCNN1A SEC14L2 SEMA3B SFN SH3BP5 SIAH2 SLC16A1 SLC19A2 SLC1A1 SLC1A4 SLC22A5 SLC24A3 SLC26A2 SLC27A2 SLC2A1 SLC37A1 SLC39A6 SLC7A2 SLC7A5 SLC9A3R1 SNX24 SOX3 STC2 SULT2B1 SVIL SYBU SYNGR1 SYT12 TBC1D30 TFAP2C TFF1 TFF3 TGIF2 TGM2 THSD4 TIAM1 TIPARP TJP3 TMEM164 TMPRSS3 TOB1 TPBG TPD52L1 TSKU TTC39A TUBB2B UGCG UNC119 WFS1 WISP2 WWC1 XBP1 ZNF185 +HALLMARK_ESTROGEN_RESPONSE_LATE Genes defining late response to estrogen. ABCA3 ABHD2 ACOX2 ADD3 AFF1 AGR2 ALDH3A2 ALDH3B1 AMFR ANXA9 AREG ARL3 ASCL1 ASS1 ATP2B4 BAG1 BATF BCL2 BLVRB BTG3 CA12 CA2 CACNA2D2 CALCR CAV1 CCNA1 CCND1 CD44 CD9 CDC20 CDC6 CDH1 CELSR2 CHPT1 CHST8 CISH CKB CLIC3 COX6C CPE CXCL12 CXCL14 CYP26B1 CYP4F11 DCXR DHCR7 DHRS2 DLG5 DNAJC1 DNAJC12 DUSP2 DYNLT3 EGR3 ELOVL5 EMP2 ETFB FABP5 FAM102A FARP1 FDFT1 FGFR3 FKBP4 FKBP5 FLNB FOS FOXC1 FRK GAL GALE GINS2 GJB3 GLA GPER HMGCS2 HOMER2 HPRT1 HR HSPA4L HSPB8 ID2 IDH2 IGFBP4 IGSF1 IL17RB IL6ST IMPA2 ISG20 ITPK1 JAK1 JAK2 KCNK5 KIF20A KLF4 KLK10 KLK11 KRT13 KRT19 LAMC2 LARGE LLGL2 LSR LTF MAPK13 MAPT MDK MEST METTL3 MICB MOCS2 MYB MYOF NAB2 NBL1 NCOR2 NMU NPY1R NRIP1 NXT1 OLFM1 OPN3 OVOL2 PAPSS2 PCP4 PDCD4 PDLIM3 PDZK1 PERP PGR PKP3 PLA2G16 PLAC1 PLK4 PLXNB1 PPIF PRKAR2B PRLR PRSS23 PTGER3 PTGES PTPN6 RAB31 RABEP1 RAPGEFL1 RBBP8 RET RNASEH2A RPS6KA2 S100A9 SCARB1 SCNN1A SCUBE2 SEMA3B SERPINA1 SERPINA3 SERPINA5 SFN SGK1 SIAH2 SLC16A1 SLC1A4 SLC22A5 SLC24A3 SLC26A2 SLC27A2 SLC29A1 SLC2A8 SLC7A5 SLC9A3R1 SNX10 SORD SOX3 ST14 ST6GALNAC2 STIL SULT2B1 TFAP2C TFF1 TFF3 TFPI2 TH TIAM1 TJP3 TMPRSS3 TNNC1 TOB1 TOP2A TPBG TPD52L1 TPSAB1 TRIM29 TSPAN13 TST TSTA3 UGDH UNC13B WFS1 WISP2 XBP1 XRCC3 ZFP36 +HALLMARK_FATTY_ACID_METABOLISM Genes encoding proteins involved in metabolism of fatty acids. AADAT ACAA1 ACAA2 ACADL ACADM ACADS ACADVL ACAT2 ACO2 ACOT2 ACOT8 ACOX1 ACSL1 ACSL4 ACSL5 ACSM3 ACSS1 ADH1C ADH7 ADIPOR2 ADSL ALAD ALDH1A1 ALDH3A1 ALDH3A2 ALDH9A1 ALDOA AOC3 APEX1 AQP7 AUH BCKDHB BLVRA BMPR1B BPHL CA2 CA4 CA6 CBR1 CBR3 CCDC58 CD1D CD36 CEL CIDEA CPOX CPT1A CPT2 CRAT CRYZ CYP1A1 CYP4A11 CYP4A22 D2HGDH DECR1 DHCR24 DLD DLST ECH1 ECHS1 ECI1 ECI2 EHHADH ELOVL5 ENO2 ENO3 EPHX1 ERP29 ETFDH FABP1 FABP2 FASN FH FMO1 G0S2 GABARAPL1 GAD2 GAPDHS GCDH GLUL GPD1 GPD2 GRHPR GSTZ1 H2AFZ HADH HADHB HAO2 HCCS HIBCH HMGCL HMGCS1 HMGCS2 HPGD HSD17B10 HSD17B11 HSD17B4 HSD17B7 HSDL2 HSP90AA1 HSPH1 IDH1 IDH3B IDH3G IDI1 IL4I1 INMT LDHA LGALS1 LTC4S MAOA MCEE MDH1 MDH2 ME1 METAP1 MGLL MIF MLYCD NBN NCAPH2 NSDHL NTHL1 ODC1 OSTC PCBD1 PDHA1 PDHB PPARA PRDX6 PSME1 PTPRG PTS RAP1GDS1 RDH11 RDH16 REEP6 RETSAT S100A10 SDHA SDHC SDHD SERINC1 SETD8 SLC22A5 SMS SUCLA2 SUCLG1 SUCLG2 TDO2 TP53INP2 UBE2L6 UGDH UROD UROS VNN1 XIST YWHAH +HALLMARK_G2M_CHECKPOINT Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. ABL1 AMD1 ARID4A ATF5 ATRX AURKA AURKB BARD1 BCL3 BIRC5 BRCA2 BUB1 BUB3 CASC5 CASP8AP2 CBX1 CCNA2 CCNB2 CCND1 CCNF CCNT1 CDC20 CDC25A CDC25B CDC27 CDC45 CDC6 CDC7 CDK1 CDK4 CDKN1B CDKN2C CDKN3 CENPA CENPE CENPF CHAF1A CHEK1 CHMP1A CKS1B CKS2 CTCF CUL1 CUL3 CUL4A CUL5 DBF4 DDX39A DKC1 DMD DR1 DTYMK E2F1 E2F2 E2F3 E2F4 EFNA5 EGF ESPL1 EWSR1 EXO1 EZH2 FANCC FBXO5 FOXN3 G3BP1 GINS2 GSPT1 H2AFV H2AFX H2AFZ HIF1A HIRA HIST1H2BK HMGA1 HMGB3 HMGN2 HMMR HN1 HNRNPD HNRNPU HOXC10 HSPA8 HUS1 ILF3 INCENP KATNA1 KIF11 KIF15 KIF20B KIF22 KIF23 KIF2C KIF4A KIF5B KPNA2 KPNB1 LBR LIG3 LMNB1 MAD2L1 MAPK14 MARCKS MCM2 MCM3 MCM5 MCM6 MEIS1 MEIS2 MKI67 MNAT1 MT2A MTF2 MYBL2 MYC NASP NCL NDC80 NEK2 NOLC1 NOTCH2 NUMA1 NUP50 NUP98 NUSAP1 ODC1 ODF2 ORC5 ORC6 PAFAH1B1 PAPD7 PBK PDS5B PLK1 PLK4 PML POLA2 POLE POLQ PRC1 PRIM2 PRMT5 PRPF4B PTTG1 PTTG3P PURA RACGAP1 RAD21 RAD23B RAD54L RASAL2 RBL1 RBM14 RPA2 RPS6KA5 SAP30 SETD8 SFPQ SLC12A2 SLC38A1 SLC7A1 SLC7A5 SMAD3 SMARCC1 SMC1A SMC2 SMC4 SNRPD1 SQLE SRSF1 SRSF10 SRSF2 SS18 STAG1 STIL STMN1 SUV39H1 SYNCRIP TACC3 TFDP1 TGFB1 TLE3 TMPO TNPO2 TOP1 TOP2A TPX2 TRA2B TRAIP TROAP TTK UBE2C UBE2S UCK2 UPF1 WHSC1 WRN XPO1 YTHDC1 ZAK +HALLMARK_GLYCOLYSIS Genes encoding proteins involved in glycolysis and gluconeogenesis. ABCB6 ADORA2B AGL AGRN AK3 AK4 AKR1A1 ALDH7A1 ALDH9A1 ALDOA ALDOB ALG1 ANG ANGPTL4 ANKZF1 ARPP19 ARTN AURKA B3GALT6 B3GAT1 B3GAT3 B3GNT3 B4GALT1 B4GALT2 B4GALT4 B4GALT7 BIK BPNT1 CACNA1H CAPN5 CASP6 CD44 CDK1 CENPA CHPF CHPF2 CHST1 CHST12 CHST2 CHST4 CHST6 CITED2 CLDN3 CLDN9 CLN6 COG2 COL5A1 COPB2 CTH CXCR4 CYB5A DCN DDIT4 DEPDC1 DLD DPYSL4 DSC2 ECD EFNA3 EGFR EGLN3 ELF3 ENO1 ENO2 ERO1L EXT1 EXT2 FAM162A FBP2 FKBP4 FUT8 G6PD GAL3ST1 GALE GALK1 GALK2 GAPDHS GCLC GFPT1 GLCE GLRX GMPPA GMPPB GNE GNPDA1 GOT1 GOT2 GPC1 GPC3 GPC4 GPR87 GUSB GYS1 GYS2 HAX1 HDLBP HK2 HMMR HOMER1 HS2ST1 HS6ST2 HSPA5 IDH1 IDUA IER3 IGFBP3 IL13RA1 IRS2 ISG20 KDELR3 KIF20A KIF2A LCT LDHA LDHC LHPP LHX9 MDH1 MDH2 ME1 ME2 MED24 MERTK MET MIF MIOX MPI MXI1 NANP NASP NDST3 NDUFV3 NOL3 NSDHL NT5E P4HA1 P4HA2 PAM PAXIP1 PC PDK3 PFKFB1 PFKP PGAM1 PGAM2 PGK1 PGLS PGM2 PHKA2 PKM2 PKP2 PLOD1 PLOD2 PMM2 POLR3K PPFIA4 PPIA PPP2CB PRPS1 PSMC4 PYGB PYGL QSOX1 RARS RBCK1 RPE RRAGD SAP30 SDC1 SDC2 SDC3 SDHC SLC16A3 SLC25A10 SLC25A13 SLC35A3 SLC37A4 SOD1 SOX9 SPAG4 SRD5A3 STC1 STC2 STMN1 TALDO1 TFF3 TGFA TGFBI TKTL1 TPBG TPI1 TPST1 TSTA3 TXN UGP2 VCAN VEGFA VLDLR XYLT2 ZNF292 +HALLMARK_HEDGEHOG_SIGNALING Genes up-regulated by activation of hedgehog signaling. ACHE AMOT CDK5R1 CDK6 CELSR1 CNTFR CRMP1 DPYSL2 ETS2 GLI1 GPR56 HEY1 HEY2 L1CAM LDB1 MYH9 NF1 NKX6-1 NRCAM NRP1 NRP2 OPHN1 PLG PML PTCH1 RASA1 RTN1 SCG2 SHH SLIT1 THY1 TLE1 TLE3 UNC5C VEGFA VLDLR +HALLMARK_HEME_METABOLISM Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. ABCB6 ABCG2 ACP5 ACSL6 ADD1 ADD2 ADIPOR1 AGPAT4 AHSP ALAD ALAS2 ALDH1L1 ALDH6A1 ANK1 AQP3 ARHGEF12 ARL2BP ASNS ATG4A ATP6V0A1 BACH1 BCAM BLVRA BLVRB BMP2K BNIP3L BPGM BSG BTG2 BTRC C3 CA1 CA2 CAST CAT CCDC28A CCND3 CDC27 CDR2 CIR1 CLCN3 CLIC2 CPOX CROCCP2 CTNS CTSB CTSE DAAM1 DARC DCAF10 DCAF11 DCUN1D1 E2F2 EIF2AK1 ELL2 ENDOD1 EPB41 EPB42 EPB49 EPOR ERMAP EZH1 FAM46C FBXO34 FBXO7 FBXO9 FECH FN3K FOXJ2 FOXO3 FTCD GAPVD1 GATA1 GCLC GCLM GDE1 GLRX5 GMPS GYPA GYPB GYPC GYPE H1F0 HAGH HBB HBBP1 HBD HBQ1 HBZ HDGF HEBP1 HIST1H4C HMBS HTATIP2 HTRA2 ICAM4 IGSF3 ISCA1 JHDM1D KAT2B KEL KHNYN KLF1 KLF3 LAMP2 LMO2 LPIN2 LRP10 MAP2K3 MARCH2 MARCH8 MARK3 MBOAT2 MFHAS1 MGST3 MINPP1 MKRN1 MOCOS MOSPD1 MPP1 MXI1 MYL4 NARF NCOA4 NEK7 NFE2 NFE2L1 NNT NR3C1 NUDT4 OPTN OSBP2 P4HA2 PC PDZK1IP1 PGLS PICALM PIGQ PPOX PPP2R5B PQLC1 PRDX2 PSMD9 RAD23A RANBP10 RAP1GAP RBM38 RBM5 RCL1 RHAG RHCE RHD RIOK3 RNF123 RNF19A SDCBP SEC14L1 SELENBP1 SIDT2 SLC10A3 SLC11A2 SLC22A4 SLC25A37 SLC25A38 SLC2A1 SLC30A1 SLC30A10 SLC4A1 SLC6A8 SLC6A9 SLC7A11 SMOX SNCA SPTA1 SPTB SYNJ1 TAL1 TCEA1 TFDP2 TFRC TMCC2 TMEM9B TNRC6B TNS1 TOP1 TRAK2 TRIM10 TRIM58 TSPAN5 TSPO2 TYR UBAC1 UCP2 UROD UROS USP15 VEZF1 XK XPO7 YPEL5 +HALLMARK_HYPOXIA Genes up-regulated in response to low oxygen levels (hypoxia). ADM ADORA2B AK4 AKAP12 ALDOA ALDOB ALDOC AMPD3 ANGPTL4 ANKZF1 ANXA2 ATF3 ATP7A B3GALT6 B4GALNT2 BCAN BCL2 BGN BHLHE40 BNIP3L BRS3 BTG1 CA12 CASP6 CAV1 CCNG2 CCRN4L CDKN1A CDKN1B CDKN1C CHST2 CHST3 CITED2 COL5A1 CP CSRP2 CTGF CXCR4 CXCR7 CYR61 DCN DDIT3 DDIT4 DPYSL4 DTNA DUSP1 EDN2 EFNA1 EFNA3 EGFR ENO1 ENO2 ENO3 ERO1L ERRFI1 ETS1 EXT1 F3 FAM162A FBP1 FOS FOSL2 FOXO3 GAA GALK1 GAPDH GAPDHS GBE1 GCK GCNT2 GLRX GPC1 GPC3 GPC4 GPI GRHPR GYS1 HAS1 HDLBP HEXA HK1 HK2 HMOX1 HOXB9 HS3ST1 HSPA5 IDS IER3 IGFBP1 IGFBP3 IL6 ILVBL INHA IRS2 ISG20 JMJD6 JUN KDELR3 KDM3A KIF5A KLF6 KLF7 KLHL24 LALBA LARGE LDHA LDHC LOX LXN MAFF MAP3K1 MIF MT1E MT2A MXI1 MYH9 NAGK NCAN NDRG1 NDST1 NDST2 NEDD4L NFIL3 NR3C1 P4HA1 P4HA2 PAM PCK1 PDGFB PDK1 PDK3 PFKFB3 PFKL PFKP PGAM2 PGF PGK1 PGM1 PGM2 PHKG1 PIM1 PKLR PKP1 PLAC8 PLAUR PLIN2 PNRC1 PPARGC1A PPFIA4 PPP1R15A PPP1R3C PRDX5 PRKCA PRKCDBP PTRF PYGM RBPJ RORA RRAGD S100A4 SAP30 SCARB1 SDC2 SDC3 SDC4 SELENBP1 SERPINE1 SIAH2 SLC25A1 SLC2A1 SLC2A3 SLC2A5 SLC37A4 SLC6A6 SRPX STBD1 STC1 STC2 SULT2B1 TES TGFB3 TGFBI TGM2 TIPARP TKTL1 TMEM45A TNFAIP3 TPBG TPD52 TPI1 TPST2 UGP2 VEGFA VHL VLDLR WISP2 WSB1 XPNPEP1 ZFP36 ZNF292 +HALLMARK_IL2_STAT5_SIGNALING Genes up-regulated by STAT5 in response to IL2 stimulation. ABCB1 ADAM19 AGER AHCY AHNAK AHR AKAP2 ALCAM AMACR ANXA4 APLP1 ARL4A BATF BATF3 BCL2 BCL2L1 BHLHE40 BMP2 BMPR2 CA2 CAPG CAPN3 CASP3 CCDC164 CCND2 CCND3 CCNE1 CCR4 CD44 CD48 CD79B CD81 CD83 CD86 CDC42SE2 CDC6 CDCP1 CDKN1C CISH CKAP4 COCH COL6A1 CSF1 CSF2 CST7 CTLA4 CTSZ CXCL10 CYFIP1 DCPS DENND5A DHRS3 ECM1 EMP1 ENO3 ENPP1 EOMES ETV4 F2RL2 FAH FAM126B FGL2 FLT3LG FURIN GABARAPL1 GADD45B GALM GATA1 GBP4 GLIPR2 GPR65 GPR83 GPX4 GSTO1 GUCY1B3 HIPK2 HK2 HOPX HUWE1 ICOS IFITM3 IFNGR1 IGF1R IGF2R IKZF2 IKZF4 IL10 IL10RA IL13 IL18R1 IL1R2 IL1RL1 IL2RA IL2RB IL3RA IL4R IRF4 IRF6 IRF8 ITGA6 ITGAE ITGAV ITIH5 KLF6 LCLAT1 LIF LRIG1 LRRC8C LTB MAFF MAP3K8 MAP6 MAPKAPK2 METTL20 MUC1 MXD1 MYC MYO1C MYO1E N6AMT2 NCOA3 NCS1 NDRG1 NFIL3 NFKBIZ NOP2 NRP1 NT5E ODC1 P2RX4 P4HA1 PDCD2L PENK PHLDA1 PHTF2 PIM1 PLAGL1 PLEC PLIN2 PLSCR1 PNP POU2F1 PPAP2A PRAF2 PRKCH PRNP PTCH1 PTGER2 PTH1R PTRH2 PUS1 RABGAP1L RGS16 RHOB RHOH RNH1 RORA RRAGD S100A1 SCN9A SELL SELP SERPINB6 SERPINC1 SH3BGRL2 SHE SLC1A5 SLC29A2 SLC2A3 SLC39A8 SMPDL3A SNX14 SNX9 SOCS1 SOCS2 SPP1 SPRED2 SPRY4 ST3GAL4 SWAP70 SYNGR2 SYT11 TGM2 TIAM1 TLR7 TNFRSF18 TNFRSF1B TNFRSF21 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF10 TNFSF11 TRAF1 TTC39B TWSG1 UCK2 UMPS WLS XBP1 +HALLMARK_IL6_JAK_STAT3_SIGNALING Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. A2M ACVR1B ACVRL1 BAK1 CBL CCL7 CCR1 CD14 CD36 CD38 CD44 CD9 CNTFR CRLF2 CSF1 CSF2 CSF2RA CSF2RB CSF3R CXCL1 CXCL10 CXCL11 CXCL13 CXCL3 CXCL9 DNTT EBI3 FAS GRB2 HAX1 HMOX1 IFNAR1 IFNGR1 IFNGR2 IL10RB IL12RB1 IL13RA1 IL15RA IL17RA IL17RB IL18R1 IL1B IL1R1 IL1R2 IL2RA IL2RG IL3RA IL4R IL6 IL6ST IL7 IL9R INHBE IRF1 IRF9 ITGA4 ITGB3 JUN LEPR LTB LTBR MAP3K8 MYD88 OSMR PDGFC PF4 PIK3R5 PIM1 PLA2G2A PTPN1 PTPN11 PTPN2 REG1A SOCS1 SOCS3 STAM2 STAT1 STAT2 STAT3 TGFB1 TLR2 TNF TNFRSF12A TNFRSF1A TNFRSF1B TNFRSF21 TYK2 +HALLMARK_INFLAMMATORY_RESPONSE Genes defining inflammatory response. ABCA1 ABI1 ACVR1B ACVR2A ADM ADORA2B ADRM1 AHR APLNR AQP9 ATP2A2 ATP2B1 ATP2C1 AXL BDKRB1 BEST1 BST2 BTG2 C3AR1 C5AR1 CALCRL CCL17 CCL2 CCL20 CCL22 CCL24 CCL5 CCL7 CCR7 CCRL2 CD14 CD40 CD48 CD55 CD69 CD70 CD82 CDKN1A CHST2 CLEC5A CMKLR1 CSF1 CSF3 CSF3R CX3CL1 CXCL10 CXCL11 CXCL6 CXCL9 CXCR6 CYBB DCBLD2 EBI3 EDN1 EIF2AK2 EMP3 EMR1 EREG F3 FFAR2 FPR1 FZD5 GABBR1 GCH1 GNA15 GNAI3 GP1BA GPC3 GPR132 GPR183 HAS2 HBEGF HIF1A HPN HRH1 ICAM1 ICAM4 ICOSLG IFITM1 IFNAR1 IFNGR2 IL10 IL10RA IL12B IL15 IL15RA IL18 IL18R1 IL18RAP IL1A IL1B IL1R1 IL2RB IL4R IL6 IL7R IL8 INHBA IRAK2 IRF1 IRF7 ITGA5 ITGB3 ITGB8 KCNA3 KCNJ2 KCNMB2 KIF1B KLF6 LAMP3 LCK LCP2 LDLR LIF LPAR1 LTA LY6E LYN MARCO MEFV MEP1A MET MMP14 MSR1 MXD1 MYC NAMPT NDP NFKB1 NFKBIA NLRP3 NMI NMUR1 NOD2 NPFFR2 OLR1 OPRK1 OSM OSMR P2RX4 P2RX7 P2RY2 PCDH7 PDE4B PDPN PIK3R5 PLAUR PROK2 PSEN1 PTAFR PTGER2 PTGER4 PTGIR PTPRE PVR RAF1 RASGRP1 RELA RGS1 RGS16 RHOG RIPK2 RNF144B ROS1 RTP4 SCARF1 SCN1B SELE SELL SELS SEMA4D SERPINE1 SGMS2 SLAMF1 SLC11A2 SLC1A2 SLC28A2 SLC31A1 SLC31A2 SLC4A4 SLC7A1 SLC7A2 SPHK1 SRI STAB1 TACR1 TACR3 TAPBP TIMP1 TLR1 TLR2 TLR3 TNFAIP6 TNFRSF1B TNFRSF9 TNFSF10 TNFSF15 TNFSF9 TPBG VIP +HALLMARK_INTERFERON_ALPHA_RESPONSE Genes up-regulated in response to alpha interferon proteins. ADAR B2M BATF2 BST2 C1S CASP1 CASP8 CCRL2 CD47 CD74 CMPK2 CNP CSF1 CXCL10 CXCL11 DDX60 DHX58 EIF2AK2 ELF1 EPSTI1 FAM125A FAM46A FTSJD2 GBP2 GBP4 GMPR HERC6 HLA-C IFI27 IFI30 IFI35 IFI44 IFI44L IFIH1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IL15 IL4R IL7 IRF1 IRF2 IRF7 IRF9 ISG15 ISG20 LAMP3 LAP3 LGALS3BP LPAR6 LY6E MOV10 MX1 NCOA7 NMI NUB1 OAS1 OASL OGFR PARP12 PARP14 PARP9 PLSCR1 PNPT1 PRIC285 PROCR PSMA3 PSMB8 PSMB9 PSME1 PSME2 RIPK2 RNF31 RSAD2 RTP4 SAMD9 SAMD9L SELL SLC25A28 SP110 STAT2 TAP1 TDRD7 TMEM140 TRAFD1 TRIM14 TRIM21 TRIM25 TRIM26 TRIM5 TXNIP UBA7 UBE2L6 USP18 WARS +HALLMARK_INTERFERON_GAMMA_RESPONSE Genes up-regulated in response to IFNG [GeneID=3458]. ADAR APOL6 ARID5B ARL4A AUTS2 B2M BANK1 BATF2 BPGM BST2 BTG1 C1R C1S CASP1 CASP3 CASP4 CASP7 CASP8 CCL2 CCL5 CCL7 CD274 CD38 CD40 CD69 CD74 CD86 CDKN1A CFB CFH CIITA CMKLR1 CMPK2 CSF2RB CXCL10 CXCL11 CXCL9 DDX58 DDX60 DHX58 EIF2AK2 EIF4E3 EPSTI1 FAS FCGR1A FGL2 FPR1 FTSJD2 GBP4 GBP6 GCH1 GPR18 GZMA HERC6 HIF1A HLA-A HLA-B HLA-DMA HLA-DQA1 HLA-DRB1 HLA-G ICAM1 IDO1 IFI27 IFI30 IFI35 IFI44 IFI44L IFIH1 IFIT1 IFIT2 IFIT3 IFITM2 IFITM3 IFNAR2 IL10RA IL15 IL15RA IL18BP IL2RB IL4R IL6 IL7 IRF1 IRF2 IRF4 IRF5 IRF7 IRF8 IRF9 ISG15 ISG20 ISOC1 ITGB7 JAK2 KLRK1 LAP3 LATS2 LCP2 LGALS3BP LY6E LYSMD2 MARCH1 METTL7B MT2A MTHFD2 MVP MX1 MX2 MYD88 NAMPT NCOA3 NFKB1 NFKBIA NLRC5 NMI NOD1 NUP93 OAS2 OAS3 OASL OGFR P2RY14 PARP12 PARP14 PDE4B PELI1 PFKP PIM1 PLA2G4A PLSCR1 PML PNP PNPT1 PRIC285 PSMA2 PSMA3 PSMB10 PSMB2 PSMB8 PSMB9 PSME1 PSME2 PTGS2 PTPN1 PTPN2 PTPN6 RAPGEF6 RBCK1 RIPK1 RIPK2 RNF213 RNF31 RSAD2 RTP4 SAMD9L SAMHD1 SECTM1 SELP SERPING1 SLAMF7 SLC25A28 SOCS1 SOCS3 SOD2 SP110 SPPL2A SRI SSPN ST3GAL5 ST8SIA4 STAT1 STAT2 STAT3 STAT4 TAP1 TAPBP TDRD7 TNFAIP2 TNFAIP3 TNFAIP6 TNFSF10 TOR1B TRAFD1 TRIM14 TRIM21 TRIM25 TRIM26 TXNIP UBE2L6 UPP1 USP18 VAMP5 VAMP8 VCAM1 WARS XAF1 XCL1 ZBP1 ZNFX1 +HALLMARK_KRAS_SIGNALING_DN Genes down-regulated by KRAS activation. ABCB11 ABCG4 ACTC1 ADCK3 ADRA2C AKR1B10 ALOX12B AMBN ARHGDIG ARPP21 ASB7 ATP4A ATP6V1B1 BARD1 BMPR1B BRDT BTG2 C5 CACNA1F CACNG1 CALCB CALML5 CAMK1D CAPN9 CCDC106 CCDC132 CCNA1 CCR8 CD207 CD40LG CD80 CDH16 CDKAL1 CELSR2 CHRNG CHST2 CKM CLDN16 CLDN8 CLPS CLSTN3 CNTFR COL2A1 COPZ2 CPA2 CPB1 CPEB3 CYP11B2 CYP39A1 DCC DLK2 DTNB EDAR EDN1 EDN2 EFHD1 EGF ENTPD7 EPHA5 FAM164C FAM46C FGF16 FGF22 FGFR3 FGGY FSHB GAMT GDNF GP1BA GP2 GPR19 GPR3 GPRC5C GRID2 GTF3C5 H2AFY2 HNF1A HSD11B2 HTR1B HTR1D IDUA IFI44L IFNG IGFBP2 IL12B IL5 INSL5 IRS4 ITGB1BP2 ITIH3 KCND1 KCNE2 KCNMB1 KCNN1 KCNQ2 KLHDC8A KLK7 KLK8 KRT1 KRT13 KRT15 KRT4 KRT5 LFNG LGALS7 LYPD3 MAGIX MAST3 MEFV MFSD6 MLL2 MSH5 MTHFR MX1 MYH7 MYO15A MYOT NGB NOS1 NPHS1 NR4A2 NR6A1 NRIP2 NTF3 NUDT11 ODZ2 OXT P2RX6 P2RY4 PARK2 PAX3 PAX4 PCDHB1 PDCD1 PDE6B PDK2 PKP1 PLAG1 PNMT PPYR1 PRODH PROP1 PTGFR PTPRJ RGS11 RIBC2 RSAD2 RYR1 RYR2 SCGB1A1 SCN10A SEPP1 SERPINA10 SERPINB2 SGK1 SHOX2 SIDT1 SKIL SLC12A3 SLC16A7 SLC25A23 SLC29A3 SLC30A3 SLC38A3 SLC5A5 SLC6A14 SLC6A3 SMPX SNCB SNN SOX10 SPHK2 SPRR3 SPTBN2 SSTR4 STAG3 SYNPO TAS2R4 TCF7L1 TCL1A TEX15 TFAP2B TFCP2L1 TFF2 TG TGFB2 TGM1 THNSL2 THRB TLX1 TNNI3 TSHB UGT2B17 UPK3B VPREB1 WNT16 YBX2 YPEL1 ZBTB16 ZFP112 +HALLMARK_KRAS_SIGNALING_UP Genes up-regulated by KRAS activation. ABCB1 ACE ADAM17 ADAM8 ADAMDEC1 AKAP12 AKT2 ALDH1A2 ALDH1A3 AMMECR1 ANGPTL4 ANKH ANO1 ANXA10 APOD ARG1 ATG10 AVL9 BIRC3 BMP2 BPGM BTBD3 BTC C3AR1 CA2 CAB39L CBL CBR4 CBX8 CCL20 CCND2 CD37 CDADC1 CFB CFH CFHR2 CIDEA CLEC4A CMKLR1 CPE CROT CSF2 CSF2RA CTSS CXCL10 CXCR4 DCBLD2 DNMBP DOCK2 DUSP6 ELTD1 EMP1 ENG EPB41L3 EPHB2 EREG ERO1L ETS1 ETV1 ETV4 ETV5 EVI5 F13A1 F2RL1 FAM190B FBXO4 FCER1G FGF9 FLT4 FUCA1 G0S2 GABRA3 GADD45G GALNT3 GFPT2 GLRX GNG11 GPNMB GPR124 GPRC5B GUCY1A3 GYPC HBEGF HDAC9 HIST1H2BB HKDC1 HOXD11 HSD11B1 ID2 IGF2 IGFBP3 IKZF1 IL10RA IL1B IL1RL2 IL2RG IL33 IL7R INHBA IRF8 ITGA2 ITGB2 ITGBL1 JUP KCNN4 KIF5C KLF4 LAPTM5 LAT2 LCP1 LIF LY96 MAFB MALL MAP3K1 MAP4K1 MAP7 MMD MMP10 MMP11 MMP9 MPZL2 MTMR10 MYCN NAP1L2 NGF NIN NR0B2 NR1H4 NRP1 PCP4 PCSK1N PDCD1LG2 PECAM1 PEG3 PIGR PLAT PLAU PLAUR PLEK2 PLVAP PPBP PPP1R15A PRDM1 PRKG2 PRRX1 PSMB8 PTBP2 PTCD2 PTGS2 PTPRR RABGAP1L RBM4 RBP4 RELN RETN RGS16 SATB1 SCG3 SCG5 SCN1B SDCCAG8 SEMA3B SERPINA3 SLMO2 SLPI SNAP25 SNAP91 SOX9 SPARCL1 SPON1 SPP1 SPRY2 ST6GAL1 STRN TFPI TLR8 TMEM100 TMEM158 TMEM176A TMEM176B TNFAIP3 TNFRSF1B TNNT2 TOR1AIP2 TPH1 TRAF1 TRIB1 TRIB2 TSPAN1 TSPAN13 TSPAN7 USH1C USP12 VWA5A WDR33 WNT7A YRDC ZNF277 ZNF639 +HALLMARK_MITOTIC_SPINDLE Genes important for mitotic spindle assembly. ABI1 ABL1 ABR ACTN4 AKAP13 ALMS1 ALS2 ANLN APC ARAP3 ARF6 ARFGEF1 ARFIP2 ARHGAP10 ARHGAP27 ARHGAP29 ARHGAP4 ARHGAP5 ARHGDIA ARHGEF11 ARHGEF12 ARHGEF2 ARHGEF3 ARHGEF7 ARL8A ATG4B AURKA AZI1 BCAR1 BCL2L11 BCR BIN1 BIRC5 BRCA2 BUB1 CAPZB CCDC88A CCNB2 CD2AP CDC27 CDC42 CDC42BPA CDC42EP1 CDC42EP2 CDC42EP4 CDK1 CDK5RAP2 CENPE CENPF CENPJ CEP192 CEP250 CEP57 CEP72 CKAP5 CLASP1 CLIP1 CLIP2 CNTRL CNTROB CRIPAK CSNK1D CTTN CYTH2 DLG1 DLGAP5 DOCK2 DOCK4 DST DYNC1H1 DYNLL2 ECT2 EPB41 EPB41L2 ESPL1 EZR FARP1 FBXO5 FGD4 FGD6 FLNA FLNB FSCN1 GEMIN4 GSN HDAC6 HOOK3 INCENP ITSN1 KATNA1 KATNB1 KIF11 KIF15 KIF1B KIF20B KIF22 KIF23 KIF2C KIF3B KIF3C KIF4A KIF5B KIFAP3 KLC1 KNTC1 KPTN LATS1 LLGL1 LMNB1 LRPPRC MAP1S MAP3K11 MAPRE1 MARCKS MARK4 MID1 MID1IP1 MYH10 MYH9 MYO1E MYO9B NCK1 NCK2 NDC80 NEDD9 NEK2 NET1 NF1 NIN NOTCH2 NUMA1 NUSAP1 OPHN1 PAFAH1B1 PALLD PCGF5 PCM1 PCNT PDLIM5 PIF1 PKD2 PLEKHG2 PLK1 PPP4R2 PRC1 PREX1 PXN RAB3GAP1 RABGAP1 RACGAP1 RALBP1 RANBP9 RAPGEF5 RAPGEF6 RASA1 RASA2 RASAL2 RFC1 RHOF RHOT2 RICTOR ROCK1 SAC3D1 SASS6 SEPT9 SHROOM1 SHROOM2 SMC1A SMC3 SMC4 SORBS2 SOS1 SPTAN1 SPTBN1 SSH2 STAU1 STK38L SUN2 SYNPO TAOK2 TBCD TIAM1 TLK1 TOP2A TPX2 TRIO TSC1 TTK TUBA4A TUBD1 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 UXT VCL WASF1 WASF2 WASL YWHAE +HALLMARK_MTORC1_SIGNALING Genes up-regulated through activation of mTORC1 complex. ABCF2 ACACA ACLY ACSL3 ACTR2 ACTR3 ADD3 ADIPOR2 AK4 ALDOA ARPC5L ASNS ATP2A2 ATP5G1 ATP6V1D AURKA BCAT1 BHLHE40 BTG2 BUB1 CACYBP CALR CANX CCNF CCNG1 CCT6A CD9 CDC25A CDKN1A CFP COPS5 CORO1A CTH CTSC CXCR4 CYB5B CYP51A1 DAPP1 DDIT3 DDIT4 DDX39A DHCR24 DHCR7 DHFR EBP EDEM1 EEF1E1 EGLN3 EIF2S2 ELOVL5 ELOVL6 ENO1 EPRS ERO1L ETF1 FADS1 FADS2 FAM129A FDXR FGL2 FKBP2 G6PD GAPDH GBE1 GCLC GGA2 GLA GLRX GMPS GOT1 GPI GSK3B GSR GTF2H1 HK2 HMBS HMGCR HMGCS1 HPRT1 HSP90B1 HSPA4 HSPA5 HSPA9 HSPD1 HSPE1 IDH1 IDI1 IFI30 IFRD1 IGFBP5 IMMT INSIG1 ITGB2 LDHA LDLR LGMN LTA4H M6PR MAP2K3 MCM2 MCM4 ME1 MLLT11 MTHFD2 MTHFD2L NAMPT NFIL3 NFKBIB NFYC NMT1 NUFIP1 NUP205 NUPR1 P4HA1 PDAP1 PDK1 PFKL PGK1 PGM1 PHGDH PIK3R3 PITPNB PLK1 PLOD2 PNO1 PNP POLR3G PPA1 PPIA PPP1R15A PRDX1 PSAT1 PSMA3 PSMA4 PSMB5 PSMC2 PSMC4 PSMC6 PSMD12 PSMD13 PSMD14 PSME3 PSMG1 PSPH QDPR RAB1A RDH11 RIT1 RPA1 RPN1 RRM2 RRP9 SC5DL SCD SDF2L1 SEC11A SERP1 SERPINH1 SHMT2 SKAP2 SLA SLC1A4 SLC1A5 SLC2A1 SLC2A3 SLC37A4 SLC6A6 SLC7A11 SLC7A5 SLC9A3R1 SORD SQLE SQSTM1 SRD5A1 SSR1 STARD4 STC1 STIP1 SYTL2 TBK1 TCEA1 TES TFRC TM7SF2 TMEM97 TOMM40 TPI1 TRIB3 TUBA4A TUBG1 TXNRD1 UBE2D3 UCHL5 UFM1 UNG USO1 VLDLR WARS XBP1 YKT6 +HALLMARK_MYC_TARGETS_V1 A subgroup of genes regulated by MYC - version 1 (v1). ABCE1 ACP1 AIMP2 AP3S1 APEX1 BUB3 C1QBP CAD CANX CBX3 CCNA2 CCT2 CCT3 CCT4 CCT5 CCT7 CDC20 CDC45 CDK2 CDK4 CLNS1A CNBP COPS5 COX5A CSTF2 CTPS CUL1 CYC1 DDX18 DDX21 DEK DHX15 DUT EEF1B2 EIF1AX EIF2S1 EIF2S2 EIF3B EIF3D EIF3J EIF4A1 EIF4E EIF4G2 EIF4H EPRS ERH ETF1 EXOSC7 FAM120A FBL G3BP1 GLO1 GNB2L1 GNL3 GOT2 GSPT1 H2AFZ HDAC2 HDDC2 HDGF HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPR HNRNPU HPRT1 HSP90AB1 HSPD1 HSPE1 IARS IFRD1 ILF2 IMPDH2 KARS KPNA2 KPNB1 LDHA LSM2 LSM7 MAD2L1 MCM2 MCM4 MCM5 MCM6 MCM7 MRPL23 MRPL9 MRPS18B MYC NAP1L1 NCBP1 NCBP2 NDUFAB1 NHP2 NME1 NOLC1 NOP16 NOP56 NPM1 ODC1 ORC2 PA2G4 PABPC1 PABPC4 PCBP1 PCNA PGK1 PHB PHB2 POLD2 POLE3 PPIA PPM1G PRDX3 PRDX4 PRPF31 PRPS2 PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB2 PSMB3 PSMC4 PSMC6 PSMD1 PSMD14 PSMD3 PSMD7 PSMD8 PTGES3 PWP1 RAD23B RAN RANBP1 RFC4 RNPS1 RPL14 RPL18 RPL22 RPL34 RPL6 RPLP0 RPS10 RPS2 RPS3 RPS5 RPS6 RRM1 RRP9 RSL1D1 RUVBL2 SERBP1 SET SF3A1 SF3B3 SLC25A3 SMARCC1 SNRPA SNRPA1 SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPG SRM SRPK1 SRSF1 SRSF2 SRSF3 SRSF7 SSB SSBP1 STARD7 SYNCRIP TARDBP TCP1 TFDP1 TOMM70A TRA2B TRIM28 TUFM TXNL4A TYMS U2AF1 UBA2 UBE2E1 UBE2L3 USP1 VBP1 VDAC1 VDAC3 XPO1 XPOT XRCC6 YWHAE YWHAQ +HALLMARK_MYC_TARGETS_V2 A subgroup of genes regulated by MYC - version 2 (v2). AIMP2 BYSL CBX3 CDK4 DCTPP1 DDX18 DUSP2 EXOSC5 FARSA GNL3 GRWD1 HK2 HSPD1 HSPE1 IMP4 IPO4 LAS1L MAP3K6 MCM4 MCM5 MPHOSPH10 MRTO4 MYBBP1A MYC NDUFAF4 NIP7 NOC4L NOLC1 NOP16 NOP2 NOP56 NPM1 PA2G4 PES1 PHB PLK1 PLK4 PPAN PPRC1 PRMT3 PUS1 RABEPK RCL1 RRP12 RRP9 SLC19A1 SLC29A2 SORD SRM SUPV3L1 TBRG4 TCOF1 TFB2M TMEM97 UNG UTP20 WDR43 WDR74 +HALLMARK_MYOGENESIS Genes involved in development of skeletal muscle (myogenesis). ABLIM1 ACHE ACSL1 ACTA1 ACTC1 ACTN2 ACTN3 ADAM12 ADCY9 AEBP1 AGL AGRN AK1 AKT2 ANKRD2 APLNR APOD APP ATP2A1 ATP6AP1 BAG1 BDKRB2 BHLHE40 BIN1 CACNA1H CACNG1 CAMK2B CASQ1 CASQ2 CAV3 CD36 CDH13 CDKN1A CFD CHRNA1 CHRNB1 CHRNG CKB CKM CKMT2 CLU CNN3 COL15A1 COL1A1 COL3A1 COL4A2 COL6A2 COL6A3 COX6A2 COX7A1 CRAT CRYAB CSRP3 CTF1 DAPK2 DES DMD DMPK DTNA EFS EIF4A2 ENO3 EPHB3 ERBB3 FABP3 FDPS FGF2 FHL1 FKBP1B FLII FOXO4 FST FXYD1 GAA GABARAPL2 GADD45B GJA5 GNAO1 GPX3 GSN HBEGF HDAC5 HRC HSPB2 HSPB8 IFRD1 IGF1 IGFBP3 IGFBP7 ITGA7 ITGB1 ITGB4 ITGB5 KCNH1 KCNH2 KIFC3 KLF5 LAMA2 LARGE LDB3 LPIN1 LSP1 MAPK12 MAPRE3 MB MEF2A MEF2C MEF2D MRAS MYBPC3 MYBPH MYF6 MYH1 MYH11 MYH2 MYH3 MYH4 MYH7 MYH8 MYH9 MYL1 MYL2 MYL3 MYL4 MYL6B MYL7 MYLK MYLPF MYO1C MYOG MYOM1 MYOM2 MYOZ1 NAV2 NCAM1 NOS1 NOTCH1 NQO1 OCEL1 PC PDE4DIP PDLIM7 PFKM PGAM2 PICK1 PKIA PLXNB2 PPFIA4 PPP1R3C PRNP PSEN2 PTGIS PTP4A3 PVALB PYGM RB1 REEP1 RIT1 RYR1 SCD SCHIP1 SGCA SGCD SGCG SH2B1 SH3BGR SIRT2 SLC6A8 SLN SMTN SOD3 SORBS1 SORBS3 SPARC SPDEF SPEG SPHK1 SPTAN1 SSPN ST5 STC2 SVIL SYNGR2 TAGLN TCAP TEAD4 TGFB1 TNNC1 TNNC2 TNNI1 TNNI2 TNNT1 TNNT2 TNNT3 TPD52L1 TPM2 TPM3 TSC2 VIPR1 WWTR1 +HALLMARK_NOTCH_SIGNALING Genes up-regulated by activation of Notch signaling. APH1A ARRB1 CCND1 CUL1 DLL1 DTX1 DTX2 DTX4 FBXW11 FZD1 FZD5 FZD7 HES1 HEYL JAG1 KAT2A LFNG MAML2 NOTCH1 NOTCH2 NOTCH3 PPARD PRKCA PSEN2 PSENEN RBX1 SAP30 SKP1 ST3GAL6 TCF7L2 WNT2 WNT5A +HALLMARK_OXIDATIVE_PHOSPHORYLATION Genes encoding proteins involved in oxidative phosphorylation. ABCB7 ACAA1 ACAA2 ACADM ACADSB ACADVL ACAT1 ACO2 AFG3L2 AIFM1 ALAS1 ALDH6A1 ATP1B1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6AP1 ATP6V0B ATP6V0C ATP6V0E1 ATP6V1C1 ATP6V1D ATP6V1E1 ATP6V1F ATP6V1G1 ATP6V1H BAX BCKDHA BDH2 BRP44L CASP7 COX10 COX11 COX15 COX17 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2 COX7A2L COX7B COX7C COX8A CPT1A CS CYB5A CYB5R3 CYC1 CYCS DECR1 DLAT DLD DLST ECH1 ECHS1 ECI1 ETFA ETFB ETFDH FDX1 FH FXN GLUD1 GOT2 GPI GPX4 GRPEL1 HADHA HADHB HCCS HSD17B10 HSPA9 HTRA2 IDH1 IDH2 IDH3A IDH3B IDH3G IMMT ISCA1 ISCU LDHA LDHB LRPPRC MAOB MDH1 MDH2 MFN2 MGST3 MRPL11 MRPL15 MRPL34 MRPL35 MRPS11 MRPS12 MRPS15 MRPS22 MRPS30 MTRF1 MTRR MTX2 NDUFA1 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NNT NQO2 OAT OGDH OPA1 OXA1L PDHA1 PDHB PDHX PDK4 PDP1 PHB2 PHYH PMPCA POLR2F POR PRDX3 RETSAT RHOT1 RHOT2 SDHA SDHB SDHC SDHD SLC25A11 SLC25A12 SLC25A20 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SUCLA2 SUCLG1 SUPV3L1 SURF1 TCIRG1 TIMM10 TIMM13 TIMM17A TIMM50 TIMM8B TIMM9 TOMM22 TOMM70A UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ VDAC1 VDAC2 VDAC3 +HALLMARK_P53_PATHWAY Genes involved in p53 pathways and networks. ABAT ABCC5 ABHD4 ACVR1B ADA ADCK3 AEN AK1 ALOX15B ANKRA2 APAF1 APP ATF3 BAIAP2 BAK1 BAX BLCAP BMP2 BTG1 BTG2 CASP1 CCND2 CCND3 CCNG1 CCNK CCP110 CD81 CD82 CDH13 CDK5R1 CDKN1A CDKN2A CDKN2AIP CDKN2B CEBPA CGRRF1 CLCA2 CSRNP2 CTSD CTSF CYFIP2 DCXR DDB2 DDIT3 DDIT4 DEF6 DGKA DNTTIP2 DRAM1 EI24 EPHA2 EPHX1 EPS8L2 ERCC5 F2R FAM162A FAS FBXW7 FDXR FGF13 FOS FOXO3 FUCA1 GADD45A GLS2 GM2A GNB2L1 GPX2 H2AFJ HBEGF HDAC3 HEXIM1 HINT1 HIST1H1C HIST3H2A HMOX1 HRAS HSPA4L IER3 IER5 IFI30 IKBKAP IL1A INHBB IP6K2 IRAK1 ISCU ITGB4 JAG2 JUN KIF13B KLF4 KLK8 KRT17 LDHB LIF LRMP MAPKAPK3 MDM2 MKNK2 MXD1 MXD4 NDRG1 NHLH2 NINJ1 NOL8 NOTCH1 NUDT15 NUPR1 OSGIN1 PCNA PDGFA PERP PHLDA3 PIDD PITPNC1 PLK2 PLK3 PLXNB2 PMM1 POLH POM121 PPM1D PPP1R15A PRKAB1 PRMT2 PROCR PTPN14 PTPRE PVT1 RAB40C RAD51C RAD9A RALGDS RAP2B RB1 RCHY1 RETSAT RGS16 RHBDF2 RNF19B RPL18 RPL36 RPS12 RPS27L RRAD RRP8 RXRA S100A10 S100A4 SAT1 SDC1 SEC61A1 SERPINB5 SERTAD3 SESN1 SFN SLC19A2 SLC35D1 SLC3A2 SLC7A11 SOCS1 SP1 SPHK1 ST14 STEAP3 STOM TAP1 TAX1BP3 TCHH TCN2 TGFA TGFB1 TM4SF1 TM7SF3 TNFSF9 TNNI1 TOB1 TP53 TP63 TPD52L1 TPRKB TRAF4 TRAFD1 TRIAP1 TRIB3 TSC22D1 TSPYL2 TXNIP UPP1 VAMP8 VDR VWA5A WRAP73 WWP1 XPC ZBTB16 ZFP36L1 ZMAT3 ZNF365 +HALLMARK_PANCREAS_BETA_CELLS Genes specifically up-regulated in pancreatic beta cells. ABCC8 AKT3 CHGA DCX DPP4 ELP4 FOXA2 FOXO1 G6PC2 GCG GCK HNF1A IAPP INS INSM1 ISL1 LMO2 MAFB NEUROD1 NEUROG3 NKX2-2 NKX6-1 PAK3 PAX4 PAX6 PCSK1 PCSK2 PDX1 PKLR SCGN SEC11A SLC2A2 SPCS1 SRP14 SRP9 SRPRB SST STXBP1 SYT13 VDR +HALLMARK_PEROXISOME Genes encoding components of peroxisome. ABCB1 ABCB4 ABCB9 ABCC5 ABCC8 ABCD1 ABCD2 ABCD3 ACAA1 ACOT8 ACOX1 ACSL1 ACSL4 ACSL5 ALB ALDH1A1 ALDH9A1 ATXN1 BCL10 CACNA1B CADM1 CAT CDK7 CEL CLN6 CLN8 CNBP CRABP1 CRABP2 CRAT CTBP1 CTPS DHCR24 DHRS3 DIO1 DLG4 ECH1 ECI2 EHHADH ELOVL5 EPHX2 ERCC1 ERCC3 ESR2 FABP6 FADS1 FDPS FIS1 GNPAT GSTK1 HAO2 HMGCL HRAS HSD11B2 HSD17B11 HSD17B4 HSD3B7 IDE IDH1 IDH2 IDI1 ISOC1 ITGB1BP1 LONP2 MLYCD MSH2 MVP NR1I2 NUDT19 PABPC1 PEX11A PEX11B PEX13 PEX14 PEX2 PEX5 PEX6 PRDX1 PRDX5 RDH11 RETSAT RXRG SCGB1A1 SCP2 SEMA3C SERPINA6 SIAH1 SLC23A2 SLC25A17 SLC25A19 SLC25A4 SLC27A2 SLC35B2 SMARCC1 SOD1 SOD2 STS SULT2B1 TOP2A TSPO TTR UGT2B17 VPS4B YWHAH +HALLMARK_PI3K_AKT_MTOR_SIGNALING Genes up-regulated by activation of the PI3K/AKT/mTOR pathway. ACACA ACTR2 ACTR3 ADCY2 ADRBK1 AKT1 AKT1S1 AP2M1 ARF1 ARHGDIA ARPC3 ATF1 CAB39 CAB39L CALR CAMK4 CDK1 CDK2 CDK4 CDKN1A CDKN1B CFL1 CLTC CSNK2B CXCR4 DAPP1 DDIT3 DUSP3 E2F1 ECSIT EGFR EIF4E FASLG FGF17 FGF22 FGF6 GNA14 GNGT1 GRB2 GSK3B HRAS HSP90B1 IL2RG IL4 IRAK4 ITPR2 LCK MAP2K3 MAP2K6 MAP3K7 MAPK1 MAPK10 MAPK8 MAPK9 MAPKAP1 MKNK1 MKNK2 MYD88 NCK1 NFKBIB NGF NOD1 PAK4 PDK1 PFN1 PIK3R3 PIKFYVE PIN1 PITX2 PLA2G12A PLCB1 PLCG1 PPP1CA PPP2R1B PRKAA2 PRKAG1 PRKAR2A PRKCB PTEN PTPN11 RAC1 RAF1 RALB RIPK1 RIT1 RPS6KA1 RPS6KA3 RPTOR SFN SLA SLC2A1 SMAD2 SQSTM1 STAT2 TBK1 THEM4 TIAM1 TNFRSF1A TRAF2 TRIB3 TSC2 UBE2D3 UBE2N VAV3 YWHAB +HALLMARK_PROTEIN_SECRETION Genes involved in protein secretion pathway. ABCA1 ADAM10 ANP32E AP1G1 AP2B1 AP2M1 AP2S1 AP3B1 AP3S1 ARCN1 ARF1 ARFGAP3 ARFGEF1 ARFGEF2 ARFIP1 ATP1A1 ATP6V1B1 ATP6V1H ATP7A BET1 BNIP3 CAV2 CD63 CLCN3 CLN5 CLTA CLTC COG2 COPB1 COPB2 COPE CTSC DNM1L DOPEY1 DST EGFR ERGIC3 GALC GBF1 GLA GNAS GOLGA4 GOSR2 ICA1 IGF2R KIF1B KRT18 LAMP2 LMAN1 M6PR MAPK1 MON2 NAPA NAPG OCRL PAM PPT1 RAB14 RAB22A RAB2A RAB5A RAB9A RER1 RPS6KA3 SCAMP1 SCAMP3 SCRN1 SEC22B SEC24D SEC31A SGMS1 SH3GL2 SNAP23 SNX2 SOD1 SSPN STAM STX12 STX16 STX7 TMED10 TMED2 TMX1 TOM1L1 TPD52 TSG101 TSPAN8 USO1 VAMP3 VAMP4 VAMP7 VPS45 VPS4B YIPF6 YKT6 ZW10 +HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY Genes up-regulated by reactive oxigen species (ROS). ABCC1 ATOX1 CAT CDKN2D EGLN2 ERCC2 FES FTL G6PD GCLC GCLM GLRX GLRX2 GPX3 GPX4 GSR HBXIP HHEX HMOX2 IPCEF1 JUNB LSP1 MBP MGST1 MPO MSRA NDUFA6 NDUFB4 NDUFS2 NQO1 OXSR1 PDLIM1 PFKP PPP2R4 PRDX1 PRDX2 PRDX4 PRDX6 PRNP SBNO2 SCAF4 SELS SOD1 SOD2 SRXN1 STK25 TXN TXNRD1 TXNRD2 +HALLMARK_SPERMATOGENESIS Genes up-regulated during production of male gametes (sperm), as in spermatogenesis. ACE ACRBP ACRV1 ACTL7B ADAD1 ADAM2 ADCYAP1 AGFG1 AKAP4 ALOX15 ARL4A ART3 AURKA BRAF BUB1 CAMK4 CCNA1 CCNB2 CCT6B CDK1 CDKN3 CFTR CHFR CHRM4 CLGN CLPB CLVS1 CNIH2 COIL CRISP2 CSNK2A2 CST8 DBF4 DCC DDX25 DDX4 DMC1 DMRT1 DNAJB8 DPEP3 ELOVL3 EZH2 FAM164C GAD1 GAPDHS GFI1 GMCL1 GPR182 GRM8 GSG1 GSTM3 HBZ HIST1H1T HOXB1 HSPA1L HSPA2 HSPA4L HTR5A IDE IFT88 IL12RB2 IL13RA2 IP6K1 JAM3 KIF2C LDHC LPIN1 MAP7 MAST2 MEP1B MLF1 MLLT10 MTNR1A MTOR NAA11 NCAPH NEFH NEK2 NF2 NOS1 NPHP1 NPY5R OAZ3 ODF1 PACRG PAPOLB PARP2 PCSK1N PCSK4 PDHA2 PEBP1 PGK2 PGS1 PHF7 PHKG2 PIAS2 POMC PRKAR2A PRM2 PSMG1 RAD17 RFC4 RPL39L SCG3 SCG5 SEPT4 SHE SIRT1 SLC12A2 SLC2A5 SNAP91 SPATA6 STAM2 STRBP SYCP1 TALDO1 TCP11 TEKT2 THEG TKTL1 TLE4 TNNI3 TNP1 TNP2 TOPBP1 TSN TSSK2 TTK TUBA3C TULP2 VDAC3 YBX2 ZC3H14 ZNRF4 ZPBP +HALLMARK_TGF_BETA_SIGNALING Genes up-regulated in response to TGFB1 [GeneID=7040]. ACVR1 APC ARID4B BCAR3 BMP2 BMPR1A BMPR2 CDH1 CDK9 CDKN1C CTNNB1 ENG FKBP1A FNTA FURIN HDAC1 HIPK2 ID1 ID2 ID3 IFNGR2 JUNB KLF10 LEFTY2 LTBP2 MAP3K7 NCOR2 NOG PMEPA1 PPM1A PPP1CA PPP1R15A RAB31 RHOA SERPINE1 SKI SKIL SLC20A1 SMAD1 SMAD3 SMAD6 SMAD7 SMURF1 SMURF2 SPTBN1 TGFB1 TGFBR1 TGIF1 THBS1 TJP1 TRIM33 UBE2D3 WWTR1 XIAP +HALLMARK_TNFA_SIGNALING_VIA_NFKB Genes regulated by NF-kB in response to TNF [GeneID=7124]. ABCA1 AREG ATF3 ATP2B1 B4GALT1 B4GALT5 BCL2A1 BCL3 BCL6 BHLHE40 BIRC2 BIRC3 BMP2 BTG1 BTG2 BTG3 CCL2 CCL20 CCL4 CCL5 CCND1 CCNL1 CCRL2 CD44 CD69 CD80 CD83 CDKN1A CEBPB CEBPD CFLAR CLCF1 CSF1 CSF2 CXCL1 CXCL10 CXCL11 CXCL2 CXCL3 CXCL6 CXCR7 CYR61 DDX58 DENND5A DNAJB4 DRAM1 DUSP1 DUSP2 DUSP4 DUSP5 EDN1 EFNA1 EGR1 EGR2 EGR3 EHD1 EIF1 ETS2 F2RL1 F3 FJX1 FOS FOSB FOSL1 FOSL2 FUT4 G0S2 GADD45A GADD45B GCH1 GEM GFPT2 GPR183 HBEGF HES1 ICAM1 ICOSLG ID2 IER2 IER3 IER5 IFIH1 IFIT2 IFNGR2 IL12B IL15RA IL18 IL1A IL1B IL23A IL6 IL6ST IL7R INHBA IRF1 IRS2 JAG1 JUN JUNB KDM6B KLF10 KLF2 KLF4 KLF6 KLF9 KYNU LAMB3 LDLR LIF LITAF MAFF MAP2K3 MAP3K8 MARCKS MCL1 MSC MXD1 MYC NAMPT NFAT5 NFE2L2 NFIL3 NFKB1 NFKB2 NFKBIA NFKBIE NINJ1 NR4A1 NR4A2 NR4A3 OLR1 PANX1 PDE4B PDLIM5 PER1 PFKFB3 PHLDA1 PHLDA2 PLAU PLAUR PLEK PLK2 PMEPA1 PNRC1 PPAP2B PPP1R15A PTGER4 PTGS2 PTPRE PTX3 RCAN1 REL RELA RELB RHOB RIPK2 RNF19B SAT1 SDC4 SERPINB2 SERPINB8 SERPINE1 SGK1 SIK1 SLC16A6 SLC2A3 SLC2A6 SMAD3 SNN SOCS3 SOD2 SPHK1 SPSB1 SQSTM1 STAT5A TANK TAP1 TGIF1 TIPARP TLR2 TNC TNF TNFAIP2 TNFAIP3 TNFAIP6 TNFAIP8 TNFRSF9 TNFSF9 TNIP1 TNIP2 TRAF1 TRIB1 TRIP10 TSC22D1 TUBB2A VEGFA YRDC ZBTB10 ZC3H12A ZFP36 +HALLMARK_UNFOLDED_PROTEIN_RESPONSE Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. ALDH18A1 ARFGAP1 ASNS ATF3 ATF4 ATF6 ATP6V0D1 BAG3 BANF1 CALR CCL2 CEBPB CEBPG CHAC1 CKS1B CNOT2 CNOT4 CNOT6 CXXC1 DCP1A DCP2 DCTN1 DDIT4 DDX10 DKC1 DNAJA4 DNAJB9 DNAJC3 EDC4 EDEM1 EEF2 EIF2AK3 EIF2S1 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4EBP1 EIF4G1 ERN1 ERO1L EXOC2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC9 FKBP14 FUS GEMIN4 GOSR2 H2AFX HERPUD1 HSP90B1 HSPA5 HSPA9 HYOU1 IARS IFIT1 IGFBP1 IMP3 KDELR3 KHSRP KIF5B LSM1 LSM4 MTHFD2 NFYA NFYB NHP2 NOLC1 NOP14 NOP56 NPM1 OBFC2A PAIP1 PARN PDIA5 PDIA6 POP4 PREB PSAT1 RPS14 RRP9 SDAD1 SEC11A SEC31A SERP1 SHC1 SKIV2L2 SLC1A4 SLC30A5 SLC7A5 SPCS1 SPCS3 SRPR SRPRB SSR1 STC2 TARS TATDN2 TSPYL2 TTC37 TUBB2A VEGFA WFS1 WIPI1 XBP1 XPOT YIF1A YWHAZ ZBTB17 +HALLMARK_UV_RESPONSE_DN Genes down-regulated in response to ultraviolet (UV) radiation. ABCC1 ACVR2A ADD3 ADORA2B AGGF1 AKT3 AMPH ANXA2 ANXA4 APBB2 ARHGEF9 ATP2B1 ATP2B4 ATP2C1 ATP5S ATRN ATRX ATXN1 BCKDHB BDNF BHLHE40 BMPR1A CACNA1A CAP2 CAV1 CDC42BPA CDK13 CDKN1B CDON CELF2 CITED2 COL11A1 COL1A1 COL1A2 COL3A1 COL5A2 CYR61 DAB2 DBP DDAH1 DLC1 DLG1 DUSP1 DYRK1A EFEMP1 ERBB2 F3 FAM179B FBLN5 FHL2 FYN FZD2 GCNT1 GJA1 GRK5 HAS2 ICA1 ID1 IGF1R IGFBP5 INPP4B INSIG1 IRS1 ITGB3 KALRN KCNMA1 KIT LAMC1 LDLR LPAR1 LPHN2 LTBP1 MAGI2 MAP1B MAP2K5 MAPK14 MET MGLL MGMT MIOS MMP16 MRPS31 MT1E MTA1 MYC NEK7 NFIB NFKB1 NIPBL NOTCH2 NR1D2 NR3C1 NRP1 PAPD7 PDGFRB PDLIM5 PEX14 PHF3 PIAS3 PIK3CD PIK3R3 PLCB4 PMP22 PPAP2B PPARG PRDM2 PRKAR2B PRKCA PRKCE PTEN PTGFR PTPN21 PTPRM RASA2 RBPMS RGS4 RND3 RUNX1 RXRA SCAF8 SCHIP1 SCN8A SDC2 SERPINE1 SFMBT1 SIPA1L1 SLC22A18 SLC7A1 SMAD3 SMAD7 SNAI2 SPOP SRI SYNE1 SYNJ2 TFPI TGFBR2 TGFBR3 TJP1 VAV2 VLDLR WDR37 YTHDC1 ZMIZ1 +HALLMARK_UV_RESPONSE_UP Genes up-regulated in response to ultraviolet (UV) radiation. ABCB1 ACAA1 ALAS1 ALDOA AMD1 AP2S1 APOM AQP3 ARRB2 ASNS ATF3 ATP6V1C1 ATP6V1F BAK1 BCL2L11 BID BMP2 BSG BTG1 BTG2 BTG3 C4BPB CA2 CASP3 CCK CCND3 CCNE1 CDC34 CDC5L CDK2 CDKN1C CDKN2B CDO1 CEBPG CHKA CHRNA5 CLCN2 CLTB CNP COL2A1 CREG1 CTSL2 CXCL2 CYB5B CYB5R1 CYP1A1 DDX21 DGAT1 DLG4 DNAJA1 DNAJB1 E2F5 EIF2C2 EIF2S3 EIF5 ENO2 EPCAM EPHX1 FEN1 FGF18 FKBP4 FMO1 FOS FOSB FURIN GAL GCH1 GGH GLS GPX3 GRINA GRPEL1 H2AFX HLA-F HMOX1 HNRNPU HSPA13 HSPA2 HTR7 HYAL2 ICAM1 IGFBP2 IL6 IL6ST IRF1 JUNB KCNH2 KLHDC3 LHX2 LYN MAOA MAPK8IP2 MARK2 MGAT1 MMP14 MRPL23 MSX1 NAT1 NFKBIA NKX2-5 NPTX2 NPTXR NR4A1 NTRK3 NUPL1 NXF1 OLFM1 ONECUT1 PARP2 PDAP1 PDLIM3 PLCL1 POLE3 POLG2 POLR2H PPAT PPIF PPP1R2 PPT1 PRKACA PRKCD PRPF3 PSMC3 PTPRD RAB27A RASGRP1 RET RFC4 RHOB RPN1 RRAD RXRB SEPW1 SHOX2 SIGMAR1 SLC25A4 SLC6A12 SLC6A8 SOD2 SPR SQSTM1 STARD3 STIP1 STK25 SULT1A1 TACR3 TAP1 TARS TCHH TFRC TGFBRAP1 TMBIM6 TST TUBA4A TYRO3 UROD WIZ YKT6 +HALLMARK_WNT_BETA_CATENIN_SIGNALING Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. ADAM17 AXIN1 AXIN2 CCND2 CSNK1E CTNNB1 CUL1 DKK1 DKK4 DLL1 DVL2 FRAT1 FZD1 FZD8 GNAI1 HDAC11 HDAC2 HDAC5 HEY1 HEY2 JAG1 JAG2 KAT2A LEF1 MAML1 MYC NCOR2 NCSTN NKD1 NOTCH1 NOTCH4 NUMB PPARD PSEN2 PTCH1 RBPJ SKP2 TCF7 TP53 WNT1 WNT5B WNT6 +HALLMARK_XENOBIOTIC_METABOLISM Genes encoding proteins involved in processing of drugs and other xenobiotics. ABCC2 ABCC3 ABCD2 ABHD6 ACO2 ACOX1 ACOX2 ACOX3 ACP1 ACP2 ACSM1 ADH1C ADH5 ADH7 AHCY AKR1C2 AKR1C3 ALAS1 ALDH2 ALDH3A1 ALDH9A1 ANGPTL3 AOX1 AP4B1 APOE AQP9 ARG1 ARG2 ARPP19 ASL ATOH8 ATP2A2 BCAR1 BCAT1 BLVRB BPHL CA2 CASP6 CAT CBR1 CCL25 CD36 CDA CDO1 CES1 CFB CNDP2 COMT CROT CRP CSAD CYB5A CYFIP2 CYP17A1 CYP1A1 CYP1A2 CYP26A1 CYP27A1 CYP2C18 CYP2E1 CYP2J2 CYP2S1 CYP4F2 DAK DCXR DDAH2 DDC DDT DHPS DHRS1 DHRS7 ECH1 ELOVL5 ENPEP ENTPD5 EPHA2 EPHX1 ESR1 ETFDH ETS2 F10 F11 FABP1 FAH FAS FBLN1 FBP1 FETUB FMO1 FMO3 G6PC GABARAPL1 GAD1 GART GCH1 GCKR GCLC GCNT2 GNMT GSR GSS GSTA3 GSTM4 GSTO1 GSTT2 HACL1 HES6 HGFAC HMOX1 HNF4A HPRT1 HRG HSD11B1 HSD17B2 ID2 IDH1 IGF1 IGFBP1 IGFBP4 IL1R1 IRF8 ITIH1 ITIH4 JUP KARS KYNU LCAT LEAP2 LONP1 LPIN2 MAN1A1 MAOA MARCH6 MBL2 MCCC2 MPP2 MT2A MTHFD1 NDRG2 NFS1 NINJ1 NMT1 NPC1 NQO1 PAPSS2 PC PDK4 PDLIM5 PEMT PGD PGRMC1 PINK1 PLG PMM1 POR PPARD PROS1 PSMB10 PTGDS PTGES PTGES3 PTGR1 PTS PYCR1 RAP1GAP RBP4 REG1A RETSAT SAR1B SERPINA6 SERPINE1 SERTAD1 SHMT2 SLC12A4 SLC1A5 SLC22A1 SLC35B1 SLC35D1 SLC46A3 SLC6A12 SLC6A6 SMOX SPINT2 SSR3 TAT TDO2 TGFB2 TMBIM6 TMEM176B TMEM97 TNFRSF1A TPST1 TTPA TYR UGDH UPB1 UPP1 VNN1 VTN XDHBIOCARTA_41BB_PATHWAY > The 4-1BB-dependent immune response ATF2 CHUK IFNG IKBKB IL2 IL4 JUN MAP3K1 MAP3K5 MAP4K5 MAPK14 MAPK8 NFKB1 NFKBIA RELA TNFRSF9 TRAF2 +BIOCARTA_ACE2_PATHWAY Angiotensin-converting enzyme 2 regulates heart function ACE ACE2 AGT AGTR1 AGTR2 CMA1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 REN +BIOCARTA_ACH_PATHWAY Role of nicotinic acetylcholine receptors in the regulation of apoptosis AKT1 BAD CHRNB1 CHRNG FASLG FOXO3 MUSK PIK3CA PIK3CG PIK3R1 PTK2 PTK2B RAPSN SRC TERT YWHAH +BIOCARTA_ACTINY_PATHWAY Y branching of actin filaments ABI2 ACTA1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 NCK1 NCKAP1 NTRK1 PIR PSMA7 RAC1 WASF1 WASF2 WASF3 WASL +BIOCARTA_AGPCR_PATHWAY Attenuation of GPCR Signaling ARRB1 GNAS GNB1 GNGT1 GRK4 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB +BIOCARTA_AGR_PATHWAY Agrin in Postsynaptic Differentiation ACTA1 CDC42 CHRM1 CHRNA1 CTTN DAG1 DMD DVL1 EGFR GIT2 ITGA1 ITGB1 JUN LAMA2 LAMA3 LAMA4 MAPK1 MAPK3 MAPK8 MUSK NRG1 NRG2 NRG3 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PTK2 PXN RAC1 RAPSN SP1 SRC UTRN +BIOCARTA_AHSP_PATHWAY Hemoglobin's Chaperone AHSP ALAD ALAS1 ALAS2 CPOX FECH GATA1 HBA1 HBA2 HBB HMBS UROD UROS +BIOCARTA_AKAP13_PATHWAY Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation AKAP13 GNA12 GNA13 LPAR1 LPAR2 LPAR3 PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B RHOA +BIOCARTA_AKAP95_PATHWAY AKAP95 role in mitosis and chromosome dynamics AKAP8 CCNB1 CDK1 DDX5 NCAPD2 PPP1CA PPP2CA PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B +BIOCARTA_AKAPCENTROSOME_PATHWAY Protein Kinase A at the Centrosome AKAP9 CDK1 MAP2 NUP85 PCNT PKN1 PPP1CA PPP2CA PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B PRKCE RHOA +BIOCARTA_AKT_PATHWAY AKT Signaling Pathway AKT1 BAD CASP9 CHUK FASLG FOXO1 FOXO3 FOXO4 GH1 GHR HSP90AA1 IKBKB IKBKG NFKB1 NFKBIA PDPK1 PIK3CA PIK3CG PIK3R1 PPP2CA RELA YWHAH +BIOCARTA_ALK_PATHWAY ALK in cardiac myocytes ACVR1 APC ATF2 AXIN1 BMP10 BMP2 BMP4 BMP5 BMP7 BMPR1A BMPR2 CHRD CTNNB1 DVL1 FZD1 GATA4 GSK3B HNF1A MAP3K7 MEF2C MYL2 NKX2-5 NOG NPPA NPPB RFC1 SMAD1 SMAD4 SMAD5 SMAD6 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 WNT1 +BIOCARTA_AMI_PATHWAY Acute Myocardial Infarction AHSP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F10 F2 F2R F7 FGA FGB FGG PLAT PLG PROC PROS1 SERPINC1 TFPI +BIOCARTA_ARAP_PATHWAY ADP-Ribosylation Factor ARF1 ARFGAP1 ARFGAP3 ARFGEF1 ARFGEF2 ASAP2 CLTB COP COPA CYTH1 CYTH2 CYTH3 CYTH4 GBF1 GPLD1 KDELR1 KDELR2 KDELR3 +BIOCARTA_ARENRF2_PATHWAY Oxidative Stress Induced Gene Expression Via Nrf2 CREB1 FOS FXYD2 JUN KEAP1 MAFF MAFG MAFK MAPK1 MAPK14 MAPK8 PRKCA PRKCB +BIOCARTA_ARF_PATHWAY Tumor Suppressor Arf Inhibits Ribosomal Biogenesis ABL1 CDKN2A E2F1 MDM2 MYC PIK3CA PIK3CG PIK3R1 POLR1A POLR1B POLR1C POLR1D RAC1 RB1 TBX2 TP53 TWIST1 +BIOCARTA_ASBCELL_PATHWAY Antigen Dependent B Cell Activation CD28 CD4 CD40 CD40LG CD80 FAS FASLG HLA-DRA HLA-DRB1 IL10 IL2 IL4 +BIOCARTA_AT1R_PATHWAY Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling AGT AGTR1 ATF2 CALM1 CALM2 CALM3 CYCSP35 EGFR ELK1 GNAQ GRB2 HRAS JUN LOC124827 LOC147908 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAPK1 MAPK3 MAPK8 MEF2A MEF2BNB-MEF2B MEF2C MEF2D PAK1 PRKCA PRKCB PTK2 PTK2B RAC1 RAF1 SHC1 SOS1 SRC +BIOCARTA_ATM_PATHWAY ATM Signaling Pathway ABL1 ATM BRCA1 CDKN1A CHEK1 CHEK2 GADD45A JUN MAPK8 MDM2 MRE11A NBN NFKB1 NFKBIA RAD50 RAD51 RBBP8 RELA TP53 TP73 +BIOCARTA_ATRBRCA_PATHWAY Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility ATM ATR BRCA1 BRCA2 CHEK1 CHEK2 FANCC FANCD2 FANCE FANCF FANCG HUS1 MRE11A NBN RAD1 RAD17 RAD50 RAD51 RAD9A TP53 TREX1 +BIOCARTA_BAD_PATHWAY Regulation of BAD phosphorylation ADCY1 AKT1 BAD BAX BCL2 BCL2L1 CSF2RB IGF1 IGF1R IL3 IL3RA KIT KITLG MAPK1 MAPK3 PIK3CA PIK3CG PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RPS6KA1 YWHAH +BIOCARTA_BARR_MAPK_PATHWAY Role of fl-arrestins in the activation and targeting of MAP kinases ADCY1 ARRB1 DNM1 GNAS GNB1 GNGT1 MAP2K1 MAP2K2 MAPK1 MAPK3 PLCB1 RAF1 +BIOCARTA_BARRESTIN_PATHWAY fl-arrestins in GPCR Desensitization ADCY1 AP2A1 AP2M1 ARRB1 DNM1 GNAS GNB1 GNGT1 PLCB1 PPARA +BIOCARTA_BARRESTIN_SRC_PATHWAY Roles of fl-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling ADCY1 ARRB1 DNM1 GNAS GNB1 GNGT1 HCK HRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PLCB1 RAF1 SRC +BIOCARTA_BCELLSURVIVAL_PATHWAY B Cell Survival Pathway AKT1 BIRC5 CASP3 CASP7 CCT4 DPF2 FOS ITGA1 ITGB1 JUND MTOR PIK3CA PIK3CG PIK3R1 XIAP ZBTB7A +BIOCARTA_BCR_PATHWAY BCR Signaling Pathway BLNK BTK CALM1 CALM2 CALM3 CD79A CD79B CYCSP35 ELK1 FOS GRB2 HRAS JUN LOC124827 LOC147908 LYN MAP2K1 MAP3K1 MAPK14 MAPK3 MAPK8 NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB RAC1 RAF1 SHC1 SOS1 SYK VAV1 +BIOCARTA_BIOPEPTIDES_PATHWAY Bioactive Peptide Induced Signaling Pathway AGT AGTR2 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CDK5 CYCSP35 F2 FYN GNA11 GNAI1 GNB1 GNGT1 GRB2 HRAS JAK2 KNG1 LOC124827 LOC147908 MAP2K1 MAP2K2 MAPK1 MAPK14 MAPK3 MAPK8 MAPT MYLK PLCG1 PRKCA PRKCB PTK2B RAF1 SHC1 SOS1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 +BIOCARTA_BLYMPHOCYTE_PATHWAY B Lymphocyte Cell Surface Molecules CD40 CD80 CR1 CR2 FCGR2B HLA-DRA HLA-DRB1 ICAM1 ITGAL ITGB2 PTPRC +BIOCARTA_CACAM_PATHWAY Ca++/ Calmodulin-dependent Protein Kinase Activation CALM1 CALM2 CALM3 CAMK1 CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 CYCSP35 LOC124827 LOC147908 +BIOCARTA_CALCINEURIN_PATHWAY Effects of calcineurin in Keratinocyte Differentiation CALM1 CALM2 CALM3 CDKN1A CYCSP35 GNAQ LOC124827 LOC147908 MARCKS NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB SP1 SP3 +BIOCARTA_CARDIACEGF_PATHWAY Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy ADAM12 AGT AGTR1 EDN1 EDNRA EDNRB EGF EGFR FOS HRAS JUN MYC NFKB1 PLCG1 PRKCA PRKCB RELA RHOA +BIOCARTA_CARM1_PATHWAY Transcription Regulation by Methyltransferase of CARM1 CARM1 CREB1 CREBBP EP300 NCOA3 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RARA RXRA +BIOCARTA_CARM_ER_PATHWAY CARM1 and Regulation of the Estrogen Receptor BRCA1 CARM1 CCND1 CREBBP EP300 ERCC3 ESR1 GRIP1 GTF2A1 GTF2E1 GTF2F1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HIST2H3C MED1 MEF2C NCOR2 NR0B1 NRIP1 PELP1 PHB2 POLR2A PPARGC1A SPEN SRA1 TBP +BIOCARTA_CASPASE_PATHWAY Caspase Cascade in Apoptosis APAF1 ARHGDIB BIRC2 BIRC3 CASP1 CASP10 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CYCS DFFA DFFB GZMB LMNA LMNB1 LMNB2 PARP1 PRF1 XIAP +BIOCARTA_CBL_PATHWAY CBL mediated ligand-induced downregulation of EGF receptors CBL CSF1R EGF EGFR GRB2 MET PDGFRA PRKCA PRKCB SH3GLB1 SH3GLB2 SH3KBP1 SRC +BIOCARTA_CCR3_PATHWAY CCR3 signaling in Eosinophils CCL11 CCR3 CFL1 GNAQ GNAS GNB1 GNGT1 HRAS LIMK1 MAP2K1 MAPK1 MAPK3 MYL2 NOX1 PIK3C2G PLCB1 PPP1R12B PRKCA PRKCB PTK2 RAF1 RHOA ROCK2 +BIOCARTA_CCR5_PATHWAY Pertussis toxin-insensitive CCR5 Signaling in Macrophage CALM1 CALM2 CALM3 CCL2 CCL4 CCR5 CXCL12 CXCR4 CYCSP35 FOS GNAQ JUN LOC124827 LOC147908 MAPK14 MAPK8 PLCG1 PRKCA PRKCB PTK2B +BIOCARTA_CD40_PATHWAY CD40L Signaling Pathway CD40 CD40LG CHUK DUSP1 IKBKAP IKBKB IKBKG MAP3K1 MAP3K14 NFKB1 NFKBIA RELA TNFAIP3 TRAF3 TRAF6 +BIOCARTA_CDC42RAC_PATHWAY Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 PAK1 PDGFRA PIK3CA PIK3R1 RAC1 RHOA WASL +BIOCARTA_CDK5_PATHWAY Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway CDK5 CDK5R1 EGR1 HRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NGFR RAF1 +BIOCARTA_CDMAC_PATHWAY Cadmium induces DNA synthesis and proliferation in macrophages CUZD1 FOS HRAS JUN MAP2K1 MAPK1 MAPK3 MYC NFKB1 NFKBIA PLCB1 PRKCA PRKCB RAF1 RELA TNF +BIOCARTA_CELL2CELL_PATHWAY Cell to Cell Adhesion Signaling ACTN1 ACTN2 ACTN3 BCAR1 CSK CTNNA1 CTNNA2 CTNNA3 CTNNB1 PECAM1 PTK2 PXN SRC VCL +BIOCARTA_CELLCYCLE_PATHWAY Cyclins and Cell Cycle Regulation CCNA1 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNH CDC25A CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D E2F1 RB1 RBL1 TFDP1 +BIOCARTA_CERAMIDE_PATHWAY Ceramide Signaling Pathway AIFM1 BAD BAX BCL2 CASP8 CYCS FADD MAP2K1 MAP2K4 MAP3K1 MAPK1 MAPK3 MAPK8 NFKB1 NSMAF RAF1 RELA RIPK1 SMPD1 TNFRSF1A TRADD TRAF2 +BIOCARTA_CFTR_PATHWAY Cystic Fibrosis Transmembrane Conductance Regulator And Beta 2 Adrenergic Receptor Pathway ADCY1 ADRB2 CFTR EZR GNAS PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B SLC9A3R1 +BIOCARTA_CHEMICAL_PATHWAY Apoptotic Signaling in Response to DNA Damage AKT1 APAF1 ATM BAD BAX BCL2 BCL2L1 BID CASP3 CASP6 CASP7 CASP9 CYCS EIF2S1 PARP1 PRKCA PRKCB PTK2 PXN STAT1 TLN1 TP53 +BIOCARTA_CHREBP2_PATHWAY Regulation And Function Of ChREBP in Liver ACACA FASN GCK MLX MLXIPL PKLR PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R2D PPP2R3A PPP2R3B PPP2R4 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +BIOCARTA_CK1_PATHWAY Regulation of ck1/cdk5 by type 1 glutamate receptors CDK5 CDK5R1 CSNK1D DRD1 DRD2 GRM1 PLCB1 PPP1CA PPP1R1B PPP2CA PPP3CA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +BIOCARTA_CLASSIC_PATHWAY Classical Complement Pathway C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C9 +BIOCARTA_COMP_PATHWAY Complement Pathway C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C9 CFB CFD MASP1 MASP2 MBL2 +BIOCARTA_CREB_PATHWAY Transcription factor CREB and its extracellular signals ADCY1 AKT1 CAMK2A CAMK2B CAMK2D CAMK2G CREB1 GNAS GRB2 HRAS MAPK1 MAPK14 MAPK3 PIK3CA PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB RAC1 RPS6KA1 RPS6KA5 SOS1 +BIOCARTA_CSK_PATHWAY Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor ADCY1 CD247 CD3D CD3E CD3G CD4 CREBBP CSK GNAS GNB1 GNGT1 HLA-DRA HLA-DRB1 LCK PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPRC TRA@ TRB@ ZAP70 +BIOCARTA_CTCF_PATHWAY CTCF: First Multivalent Nuclear Factor CD79A CD79B CDKN1B CDKN2A MDM2 MTOR MYC PIK3CA PIK3CG PIK3R1 PPP2CA PTEN RPS6KB1 SMAD1 SMAD4 SMAD5 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TP53 +BIOCARTA_CTL_PATHWAY CTL mediated immune response against target cells B2M CD247 CD3D CD3E CD3G FAS FASLG GZMB HLA-A ICAM1 ITGAL ITGB2 PRF1 TRA@ TRB@ +BIOCARTA_CTLA4_PATHWAY The Co-Stimulatory Signal During T-cell Activation CD247 CD28 CD3D CD3E CD3G CD80 CD86 CTLA4 GRB2 HLA-DRA HLA-DRB1 ICOS ICOSLG IL2 ITK LCK PIK3CA PIK3R1 PTPN11 TRA@ TRB@ +BIOCARTA_CXCR4_PATHWAY CXCR4 Signaling Pathway BCAR1 CRK CXCL12 CXCR4 GNAI1 GNAQ GNB1 GNGT1 HRAS MAP2K1 MAPK1 MAPK3 NFKB1 PIK3C2G PIK3CA PIK3R1 PLCG1 PRKCA PRKCB PTK2 PTK2B PXN RAF1 RELA +BIOCARTA_CYTOKINE_PATHWAY Cytokine Network IFNA1 IFNB1 IFNG IL10 IL12A IL12B IL13 IL14 IL15 IL16 IL17A IL18 IL1A IL2 IL3 IL4 IL5 IL6 IL8 IL9 LTA TNF +BIOCARTA_D4GDI_PATHWAY D4-GDI Signaling Pathway APAF1 ARHGAP5 ARHGDIB CASP1 CASP10 CASP3 CASP8 CASP9 CYCS GZMB JUN PARP1 PRF1 +BIOCARTA_DC_PATHWAY Dendritic cells in regulating TH1 and TH2 Development ANPEP CD2 CD33 CD40 CD5 CD7 CSF2 IFNA1 IFNB1 IFNG IL10 IL12A IL12B IL13 IL3 IL4 IL5 ITGAX TLR2 TLR4 TLR7 TLR9 +BIOCARTA_DEATH_PATHWAY Induction of apoptosis through DR3 and DR4/5 Death Receptors APAF1 BCL2 BID BIRC2 BIRC3 CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CFLAR CHUK CYCS DFFA DFFB FADD GAS2 LMNA MAP3K14 NFKB1 NFKBIA RELA RIPK1 SPTAN1 TNFRSF10A TNFRSF10B TNFRSF25 TNFSF10 TNFSF12 TRADD TRAF2 XIAP +BIOCARTA_DNAFRAGMENT_PATHWAY Apoptotic DNA fragmentation and tissue homeostasis CASP3 CASP7 DFFA DFFB ENDOG GZMB HMGB1 HMGB2 TOP2A TOP2B +BIOCARTA_DREAM_PATHWAY Repression of Pain Sensation by the Transcriptional Regulator DREAM CREB1 CREM FOS JUN KCNIP3 MAPK3 OPRK1 POLR2A PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +BIOCARTA_ECM_PATHWAY Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia ARHGAP5 DIAPH1 FYN GSN HRAS ITGA1 ITGB1 MAP2K1 MAPK1 MAPK3 MYL2 MYLK PFN1 PIK3CA PIK3CG PIK3R1 PTK2 PXN RAF1 RHOA ROCK1 SHC1 SRC TLN1 +BIOCARTA_EDG1_PATHWAY Phospholipids as signalling intermediaries ADCY1 AKT1 ASAH1 GNAI1 GNB1 GNGT1 ITGAV ITGB3 MAPK1 MAPK3 PDGFA PDGFRA PIK3CA PIK3CG PIK3R1 PLCB1 PRKCA PRKCB PTK2 RAC1 RHOA S1PR1 SMPD1 SMPD2 SPHK1 SPHKAP SRC +BIOCARTA_EGF_PATHWAY EGF Signaling Pathway CSNK2A1 EGF EGFR ELK1 FOS GRB2 HRAS JAK1 JUN MAP2K1 MAP2K4 MAP3K1 MAPK3 MAPK8 PIK3CA PIK3R1 PLCG1 PRKCA PRKCB RAF1 RASA1 SHC1 SOS1 SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 +BIOCARTA_EGFR_SMRTE_PATHWAY Map Kinase Inactivation of SMRT Corepressor EGF EGFR MAP2K1 MAP3K1 MAPK14 NCOR2 RARA RXRA THRA THRB ZBTB16 +BIOCARTA_EIF2_PATHWAY Regulation of eIF2 EIF2AK1 EIF2AK2 EIF2AK3 EIF2AK4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF5 GSK3B PPP1CA +BIOCARTA_EIF4_PATHWAY Regulation of eIF4e and p70 S6 Kinase AKT1 EIF4A1 EIF4A2 EIF4E EIF4EBP1 EIF4G1 EIF4G2 EIF4G3 GHR IRS1 MAPK1 MAPK14 MAPK3 MKNK1 MTOR PABPC1 PDK2 PDPK1 PIK3CA PIK3R1 PRKCA PRKCB PTEN RPS6KB1 +BIOCARTA_EIF_PATHWAY Eukaryotic protein translation EEF2 EEF2K EIF1 EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF4A1 EIF4A2 EIF4E EIF4G1 EIF4G2 EIF4G3 EIF5 EIF6 +BIOCARTA_EPHA4_PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1 EPHA4 EPHB1 FYN ITGA1 ITGB1 L1CAM LYN RAP1B SELP +BIOCARTA_EPO_PATHWAY EPO Signaling Pathway CSNK2A1 ELK1 EPO EPOR FOS GRB2 HRAS JAK2 JUN MAP2K1 MAPK3 MAPK8 PLCG1 PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B +BIOCARTA_EPONFKB_PATHWAY Erythropoietin mediated neuroprotection through NF-kB ARNT CDKN1A EPO EPOR GRIN1 HIF1A JAK2 NFKB1 NFKBIA RELA SOD2 +BIOCARTA_ERK5_PATHWAY Role of Erk5 in Neuronal Survival AKT1 CREB1 GRB2 HRAS MAPK1 MAPK3 MAPK7 MEF2A MEF2BNB-MEF2B MEF2C MEF2D NTRK1 PIK3CA PIK3CG PIK3R1 PLCG1 RPS6KA1 SHC1 +BIOCARTA_ERK_PATHWAY Erk1/Erk2 Mapk Signaling pathway EGFR ELK1 GNAS GNB1 GNGT1 GRB2 HRAS IGF1R ITGB1 MAP2K1 MAP2K2 MAPK1 MAPK3 MKNK1 MKNK2 MYC NGF NGFR PDGFRA PPP2CA PTPRR RAF1 RPS6KA1 RPS6KA5 SHC1 SOS1 SRC STAT3 +BIOCARTA_ERYTH_PATHWAY Erythrocyte Differentiation Pathway CCL3 CSF2 CSF3 EPO FLT3 IGF1 IL11 IL1A IL3 IL6 IL9 KITLG TGFB1 TGFB2 TGFB3 +BIOCARTA_ETC_PATHWAY Electron Transport Reaction in Mitochondria ATP5A1 COX1 CYCS GPD2 NDUFA1 SDHA SDHB SDHC SDHD SLC25A4 SLC25A6 UQCRC1 +BIOCARTA_ETS_PATHWAY METS affect on Macrophage Differentiation CSF1 CSF1R DDX20 E2F1 E2F4 ETS1 ETS2 ETV3 FOS HDAC2 HDAC5 HRAS JUN NCOR2 RBL1 RBL2 SIN3A SIN3B +BIOCARTA_EXTRINSIC_PATHWAY Extrinsic Prothrombin Activation Pathway F10 F2 F2R F3 F5 F7 FGA FGB FGG PROC PROS1 SERPINC1 TFPI +BIOCARTA_FAS_PATHWAY FAS signaling pathway ( CD95 ) ARHGDIB CASP10 CASP3 CASP6 CASP7 CASP8 CFLAR DAXX DFFA DFFB FADD FAF1 FAS FASLG JUN LMNA LMNB1 LMNB2 MAP2K4 MAP3K1 MAP3K7 MAPK8 PAK1 PAK2 PARP1 PRKDC PTPN13 RB1 RIPK2 SPTAN1 +BIOCARTA_FCER1_PATHWAY Fc Epsilon Receptor I Signaling in Mast Cells BTK CALM1 CALM2 CALM3 CYCSP35 ELK1 FCER1A FCER1G FOS GRB2 HRAS JUN LOC124827 LOC147908 LYN MAP2K1 MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK3 MAPK8 NFATC1 NFATC2 NFATC3 NFATC4 PAK2 PIK3CA PIK3CG PIK3R1 PLA2G4A PLCG1 PPP3CA PPP3CB PPP3CC PRKCB RAF1 SHC1 SOS1 SYK VAV1 +BIOCARTA_FEEDER_PATHWAY Feeder Pathways for Glycolysis HK1 KHK LCT MPI PGM1 PYGL PYGM TPI1 TREH +BIOCARTA_FIBRINOLYSIS_PATHWAY Fibrinolysis Pathway CPB2 F13A1 F2 F2R FGA FGB FGG PLAT PLAU PLG SERPINB2 SERPINE1 +BIOCARTA_FMLP_PATHWAY fMLP induced chemokine gene expression in HMC-1 cells CALM1 CALM2 CALM3 CAMK1 CAMK1G CYCSP35 ELK1 FPR1 GNA15 GNB1 GNGT1 HRAS LOC124827 LOC147908 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP3K1 MAPK1 MAPK14 MAPK3 NCF1C NCF2 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA PAK1 PIK3C2G PLCB1 PPP3CA PPP3CB PPP3CC RAC1 RAF1 RELA +BIOCARTA_FREE_PATHWAY Free Radical Induced Apoptosis GPX1 GSR GSS IL8 NFKB1 NOX1 RELA SOD1 TNF XDH +BIOCARTA_G1_PATHWAY Cell Cycle: G1/S Check Point ABL1 ATM ATR CCNA1 CCND1 CCNE1 CDC25A CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B DHFR E2F1 GSK3B HDAC1 RB1 SKP2 SMAD3 SMAD4 TFDP1 TGFB1 TGFB2 TGFB3 TP53 +BIOCARTA_G2_PATHWAY Cell Cycle: G2/M Checkpoint ATM ATR BRCA1 CCNB1 CDC25A CDC25B CDC25C CDC34 CDK1 CDKN1A CDKN2D CHEK1 CHEK2 EP300 GADD45A MDM2 MYT1 PLK1 PRKDC RPS6KA1 TP53 WEE1 YWHAH YWHAQ +BIOCARTA_GABA_PATHWAY Gamma-aminobutyric Acid Receptor Life Cycle DNM1 GABARAP GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GPHN SRC +BIOCARTA_GATA3_PATHWAY GATA3 participate in activating the Th2 cytokine genes expression GATA3 IL13 IL4 IL5 JUNB MAF MAP2K3 MAPK14 NFATC1 NFATC2 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +BIOCARTA_GCR_PATHWAY Corticosteroids and cardioprotection ADRB2 AKT1 ANXA1 CALM1 CALM2 CALM3 CORIN CYCSP35 GNAS GNB1 GNGT1 HSP90AA1 LOC124827 LOC147908 NFKB1 NOS3 NPPA NR3C1 PIK3CA PIK3CG PIK3R1 RELA +BIOCARTA_GH_PATHWAY Growth Hormone Signaling Pathway GH1 GHR GRB2 HNF1A HRAS INS INSR IRS1 JAK2 MAP2K1 MAPK1 MAPK3 PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB PTPN6 RAF1 RPS6KA1 SHC1 SLC2A4 SOCS1 SOS1 SRF STAT5A STAT5B +BIOCARTA_GLEEVEC_PATHWAY Inhibition of Cellular Proliferation by Gleevec AKT1 BAD BCR CRKL FOS GRB2 HRAS JAK2 JUN MAP2K1 MAP2K4 MAP3K1 MAPK3 MAPK8 MYC PIK3CA PIK3CG PIK3R1 RAF1 SOS1 STAT1 STAT5A STAT5B +BIOCARTA_GLYCOLYSIS_PATHWAY Glycolysis Pathway ALDOB ENO1 GAPDH GPI HK1 PFKL PGAM1 PGK1 PKLR TPI1 +BIOCARTA_GPCR_PATHWAY Signaling Pathway from G-Protein Families ADCY1 CALM1 CALM2 CALM3 CREB1 CYCSP35 ELK1 FOS GNAI1 GNAQ GNAS GNB1 GNGT1 HRAS JUN LOC124827 LOC147908 MAP2K1 MAPK3 NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB RAF1 RPS6KA3 +BIOCARTA_GRANULOCYTES_PATHWAY Adhesion and Diapedesis of Granulocytes C5 CSF3 ICAM1 IFNG IL1A IL8 ITGAL ITGAM ITGB2 PECAM1 SELL SELP SELPLG TNF +BIOCARTA_GSK3_PATHWAY Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages AKT1 APC AXIN1 CCND1 CD14 CTNNB1 DVL1 EIF2AK2 FZD1 GJA1 GNAI1 GSK3B IRAK1 LBP LEF1 LY96 MYD88 NFKB1 PDPK1 PIK3CA PIK3R1 PPP2CA RELA TIRAP TLR4 TOLLIP WNT1 +BIOCARTA_HCMV_PATHWAY Human Cytomegalovirus and Map Kinase Pathways AKT1 CREB1 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP3K1 MAPK1 MAPK14 MAPK3 NFKB1 PIK3CA PIK3CG PIK3R1 RB1 RELA SP1 +BIOCARTA_HDAC_PATHWAY Control of skeletal myogenesis by HDAC and calcium/calmodulin-dependent kinase (CaMK) AKT1 CABIN1 CALM1 CALM2 CALM3 CAMK1 CAMK1G CYCSP35 HDAC5 IGF1 IGF1R INS INSR LOC124827 LOC147908 MAP2K6 MAPK14 MAPK7 MEF2A MEF2BNB-MEF2B MEF2C MEF2D MYOD1 NFATC1 NFATC2 PIK3CA PIK3CG PIK3R1 PPP3CA PPP3CB PPP3CC YWHAH +BIOCARTA_HER2_PATHWAY Role of ERBB2 in Signal Transduction and Oncology CARM1 EGFR EP300 ERBB3 ERBB4 ESR1 GRB2 GRIP1 HRAS IL6 IL6R IL6ST MAP2K1 MAPK1 MAPK3 PIK3CA PIK3CG PIK3R1 RAF1 SHC1 SOS1 STAT3 +BIOCARTA_HIF_PATHWAY Hypoxia-Inducible Factor in the Cardiovascular System ARNT ASPH COPS5 CREB1 EDN1 EP300 EPO HIF1A HSP90AA1 JUN LDHA NOS3 P4HB VEGFA VHL +BIOCARTA_HIVNEF_PATHWAY HIV-I Nef: negative effector of Fas and TNF ACTG1 APAF1 ARHGDIB BAG4 BCL2 BID BIRC2 BIRC3 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CDK11A CDK11B CFLAR CHUK CRADD CYCS DAXX DFFA DFFB FADD FAS FASLG GSN LMNA LMNB1 LMNB2 MAP2K7 MAP3K1 MAP3K14 MAP3K5 MAPK8 MDM2 NFKB1 NFKBIA NUMA1 PAK2 PARP1 PRKCD PRKDC PSEN1 PSEN2 PTK2 RASA1 RB1 RELA RIPK1 SPTAN1 TNF TNFRSF1A TNFRSF1B TRADD TRAF1 TRAF2 XIAP +BIOCARTA_HSP27_PATHWAY Stress Induction of HSP Regulation ACTA1 APAF1 BCL2 CASP3 CASP9 CYCS DAXX FAS FASLG HSPB1 HSPB2 IL1A MAPKAPK2 MAPKAPK3 TNF +BIOCARTA_IGF1_PATHWAY IGF-1 Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS IGF1 IGF1R IRS1 JUN MAP2K1 MAPK3 MAPK8 PIK3CA PIK3CG PIK3R1 PTPN11 RAF1 RASA1 SHC1 SOS1 SRF +BIOCARTA_IGF1MTOR_PATHWAY Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway AKT1 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF4E EIF4EBP1 GSK3B IGF1 IGF1R INPPL1 MTOR PDK2 PDPK1 PIK3CA PIK3R1 PPP2CA PTEN RPS6 RPS6KB1 +BIOCARTA_IGF1R_PATHWAY Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation ADCY1 AKT1 BAD GRB2 HRAS IGF1R IRS1 MAP2K1 MAPK1 MAPK3 PIK3CA PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAF1 RPS6KA1 SHC1 SOS1 YWHAH +BIOCARTA_IL10_PATHWAY IL-10 Anti-inflammatory Signaling Pathway BLVRA BLVRB HMOX1 IL10 IL10RA IL10RB IL1A IL6 JAK1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TNF +BIOCARTA_IL12_PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5 CD247 CD3D CD3E CD3G CXCR3 ETV5 IFNG IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 JAK2 JUN MAP2K6 MAPK14 MAPK8 STAT4 TRA@ TRB@ TYK2 +BIOCARTA_IL17_PATHWAY IL 17 Signaling Pathway CD2 CD247 CD34 CD3D CD3E CD3G CD4 CD58 CD8A CSF3 IL17A IL3 IL6 IL8 KITLG TRA@ TRB@ +BIOCARTA_IL1R_PATHWAY Signal transduction through IL1R CHUK ECSIT IFNA1 IFNB1 IKBKB IL1A IL1B IL1R1 IL1RAP IL1RN IL6 IRAK1 IRAK2 IRAK3 JUN MAP2K3 MAP2K6 MAP3K1 MAP3K14 MAP3K7 MAPK14 MAPK8 MYD88 NFKB1 NFKBIA RELA TAB1 TGFB1 TGFB2 TGFB3 TNF TOLLIP TRAF6 +BIOCARTA_IL22BP_PATHWAY IL22 Soluble Receptor Signaling Pathway IL10RA IL22 IL22RA1 IL22RA2 JAK1 JAK2 JAK3 SOCS3 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TYK2 +BIOCARTA_IL2_PATHWAY IL 2 signaling pathway CSNK2A1 ELK1 FOS GRB2 HRAS IL2 IL2RA IL2RB IL2RG JAK1 JAK3 JUN LCK MAP2K1 MAPK3 MAPK8 RAF1 SHC1 SOS1 STAT5A STAT5B SYK +BIOCARTA_IL2RB_PATHWAY IL-2 Receptor Beta Chain in T cell Activation AKT1 BAD BCL2 BCL2L1 CBL CFLAR CRKL E2F1 FAS FASLG FOS GRB2 HRAS IKZF3 IL2RA IL2RB IL2RG IRS1 JAK1 JAK3 MAPK1 MAPK3 MYC NMI PIK3CA PIK3CG PIK3R1 PPIA PTPN6 RAF1 RPS6KB1 SHC1 SOCS1 SOCS3 SOS1 STAT5A STAT5B SYK +BIOCARTA_IL3_PATHWAY IL 3 signaling pathway CSF2RB FOS GRB2 HRAS IL3 IL3RA JAK2 MAP2K1 MAPK3 PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B +BIOCARTA_IL4_PATHWAY IL 4 signaling pathway AKT1 GRB2 IL2RG IL4 IL4R IRS1 JAK1 JAK3 RPS6KB1 SHC1 STAT6 +BIOCARTA_IL5_PATHWAY IL 5 Signaling Pathway CCL11 CCR3 CD4 HLA-DRA HLA-DRB1 IL1B IL4 IL5 IL5RA IL6 +BIOCARTA_IL6_PATHWAY IL 6 signaling pathway CEBPB CSNK2A1 ELK1 FOS GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 JAK3 JUN MAP2K1 MAPK3 PTPN11 RAF1 SHC1 SOS1 SRF STAT3 TYK2 +BIOCARTA_IL7_PATHWAY IL-7 Signal Transduction BCL2 CREBBP EP300 FYN IL2RG IL7 IL7R JAK1 JAK3 LCK NMI PIK3CA PIK3CG PIK3R1 PTK2B STAT5A STAT5B +BIOCARTA_INFLAM_PATHWAY Cytokines and Inflammatory Response CD4 CSF1 CSF2 CSF3 HLA-DRA HLA-DRB1 IFNA1 IFNB1 IFNG IL10 IL11 IL12A IL12B IL13 IL15 IL1A IL2 IL3 IL4 IL5 IL6 IL7 IL8 LTA PDGFA TGFB1 TGFB2 TGFB3 TNF +BIOCARTA_INSULIN_PATHWAY Insulin Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS INS INSR IRS1 JUN MAP2K1 MAPK3 MAPK8 PIK3CA PIK3CG PIK3R1 PTPN11 RAF1 RASA1 SHC1 SLC2A4 SOS1 SRF +BIOCARTA_INTEGRIN_PATHWAY Integrin Signaling Pathway ACTA1 ACTN1 ACTN2 ACTN3 BCAR1 BCR CAPN1 CAPNS1 CAPNS2 CAV1 CRKL CSK FYN GRB2 HRAS ITGA1 ITGB1 JUN MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK8 PPP1R12B PTK2 PXN RAF1 RAP1A RAPGEF1 RHOA ROCK1 SHC1 SOS1 SRC TLN1 TNS1 VCL ZYX +BIOCARTA_INTRINSIC_PATHWAY Intrinsic Prothrombin Activation Pathway COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F10 F11 F12 F2 F2R F5 F8 F9 FGA FGB FGG KLKB1 KNG1 PROC PROS1 SERPINC1 SERPING1 +BIOCARTA_KERATINOCYTE_PATHWAY Keratinocyte Differentiation BCL2 CEBPA CHUK DAXX EGF EGFR ETS1 ETS2 FAS FASLG FOS HOXA7 HRAS IKBKB JUN MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K14 MAP3K5 MAPK1 MAPK13 MAPK14 MAPK3 MAPK8 NFKB1 NFKBIA PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ RAF1 RELA RIPK1 SP1 TNF TNFRSF1A TNFRSF1B TRAF2 +BIOCARTA_KREB_PATHWAY The Citric Acid Cycle ACO2 CS FH IDH2 MDH1 OGDH SDHA SUCLA2 +BIOCARTA_LAIR_PATHWAY Cells and Molecules involved in local acute inflammatory response C3 C5 C6 C7 ICAM1 IL1A IL6 IL8 ITGA4 ITGAL ITGB1 ITGB2 KNG1 SELP SELPLG TNF VCAM1 +BIOCARTA_LECTIN_PATHWAY Lectin Induced Complement Pathway C2 C3 C4A C4B C5 C6 C7 C8A C9 MASP1 MASP2 MBL2 +BIOCARTA_LEPTIN_PATHWAY Reversal of Insulin Resistance by Leptin ACACA CPT1A LEP LEPR PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 +BIOCARTA_LONGEVITY_PATHWAY The IGF-1 Receptor and Longevity AKT1 CAT FOXO3 GH1 GHR HRAS IGF1 IGF1R PIK3CA PIK3CG PIK3R1 SHC1 SOD1 SOD2 SOD3 +BIOCARTA_LYM_PATHWAY Adhesion and Diapedesis of Lymphocytes CD34 ICAM1 IL1A IL8 ITGA4 ITGAL ITGB1 ITGB2 PECAM1 SELL VCAM1 +BIOCARTA_MAL_PATHWAY Role of MAL in Rho-Mediated Activation of SRF ACTA1 CDC42 DIAPH1 HNF1A HRAS LIMK1 MAL MAP2K1 MAP2K2 MAP3K1 MAP4K2 MAPK1 MAPK3 MAPK8 RAC1 RAF1 RHOA ROCK1 SRF +BIOCARTA_MAPK_PATHWAY MAPKinase Signaling Pathway ARAF ATF2 BRAF CEBPA CHUK CREB1 DAXX ELK1 FOS GRB2 HRAS IKBKB JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 MAP3K9 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAX MEF2A MEF2BNB-MEF2B MEF2C MEF2D MKNK1 MKNK2 MYC NFKB1 NFKBIA PAK1 PAK2 RAC1 RAF1 RAPGEF2 RELA RIPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KB1 RPS6KB2 SHC1 SP1 STAT1 TGFB1 TGFB2 TGFB3 TGFBR1 TRADD TRAF2 +BIOCARTA_MCALPAIN_PATHWAY mCalpain and friends in Cell motility ACTA1 CAPN1 CAPN2 CAPNS1 CAPNS2 CXCR3 EGF EGFR EZR HRAS ITGA1 ITGB1 MAPK1 MAPK3 MYL2 MYLK PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTK2 PXN TLN1 +BIOCARTA_MCM_PATHWAY CDK Regulation of DNA Replication CCNE1 CDC6 CDK2 CDKN1B CDT1 KITLG MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +BIOCARTA_MEF2D_PATHWAY Role of MEF2D in T-cell Apoptosis CABIN1 CALM1 CALM2 CALM3 CAPN2 CAPNS1 CAPNS2 CYCSP35 EP300 HDAC1 HDAC2 LOC124827 LOC147908 MEF2D NFATC1 NFATC2 PPP3CA PPP3CB PPP3CC PRKCA PRKCB TRA@ TRB@ +BIOCARTA_MET_PATHWAY Signaling of Hepatocyte Growth Factor Receptor ACTA1 CRK CRKL DOCK1 ELK1 FOS GAB1 GRB2 HGF HRAS ITGA1 ITGB1 JUN MAP2K1 MAP2K2 MAP4K1 MAPK1 MAPK3 MAPK8 MET PAK1 PIK3CA PIK3CG PIK3R1 PTEN PTK2 PTK2B PTPN11 PXN RAF1 RAP1A RAP1B RAPGEF1 RASA1 SOS1 SRC STAT3 +BIOCARTA_MITOCHONDRIA_PATHWAY Role of Mitochondria in Apoptotic Signaling AIFM1 APAF1 BAK1 BAX BCL2 BCL2L1 BID BIK BIRC2 BIRC3 CASP3 CASP6 CASP7 CASP8 CASP9 CYCS DFFA DFFB DIABLO ENDOG XIAP +BIOCARTA_MONOCYTE_PATHWAY Monocyte and its Surface Molecules CD44 ICAM1 ITGA4 ITGAL ITGAM ITGB1 ITGB2 PECAM1 SELE SELL SELP +BIOCARTA_MPR_PATHWAY How Progesterone Initiates Oocyte Membrane ACTA1 ACTR2 ACTR3 ADCY1 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CAP1 CCNB1 CDC25C CDK1 GNAI1 GNAS GNB1 GNGT1 HRAS MAPK1 MAPK3 MYT1 PAQR5 PAQR7 PGR PIN1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RPS6KA1 SRC +BIOCARTA_MTA3_PATHWAY Downregulated of MTA-3 in ER-negative Breast Tumors ALDOA CDH1 CTSD ESR1 GAPDH HDAC1 HSPB1 HSPB2 MBD3 MTA1 MTA3 PDZK1 SNAI1 SNAI2 TUBA1A TUBA1C TUBA3C TUBA4A TUBA4B +BIOCARTA_MTOR_PATHWAY mTOR Signaling Pathway AKT1 EIF3A EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4G2 EIF4G3 FKBP1A MKNK1 MTOR PDK2 PDPK1 PIK3CA PIK3R1 PPP2CA PTEN RPS6 RPS6KB1 TSC1 TSC2 +BIOCARTA_MYOSIN_PATHWAY PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase ARHGAP5 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 GNA12 GNA13 GNAQ GNB1 GNGT1 MYL2 MYL7 MYLK PKN1 PLCB1 PPP1R12B PRKCA PRKCB ROCK1 +BIOCARTA_NDKDYNAMIN_PATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH AP2A1 AP2M1 BIN1 CALM1 CALM2 CALM3 CYCSP35 DNM1 EPN1 EPS15 LOC124827 LOC147908 NME1 NME2 PICALM PPP3CA PPP3CB PPP3CC SYNJ1 SYNJ2 +BIOCARTA_NEUROTRANSMITTERS_PATHWAY Biosynthesis of neurotransmitters DBH GAD1 HDC PNMT TH TPH1 +BIOCARTA_NFAT_PATHWAY NFAT and Hypertrophy of the heart (Transcription in the broken heart) ACTA1 AGT AKT1 CALM1 CALM2 CALM3 CALR CAMK1 CAMK1G CAMK4 CREBBP CSNK1A1 CTF1 CYCSP35 EDN1 ELSPBP1 F2 FGF2 FKBP1A GATA4 GSK3B HAND1 HAND2 HBEGF HRAS IGF1 LIF LOC124827 LOC147908 MAP2K1 MAPK1 MAPK14 MAPK3 MAPK8 MEF2C MYH2 NFATC1 NFATC2 NFATC3 NFATC4 NKX2-5 NPPA PIK3CA PIK3CG PIK3R1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAF1 RPS6KB1 +BIOCARTA_NFKB_PATHWAY NF-kB Signaling Pathway CHUK FADD IKBKB IKBKG IL1A IL1R1 IRAK1 MAP3K1 MAP3K14 MAP3K7 MYD88 NFKB1 NFKBIA RELA RIPK1 TAB1 TLR4 TNF TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF6 +BIOCARTA_NGF_PATHWAY Nerve growth factor pathway (NGF) CSNK2A1 ELK1 FOS GRB2 HRAS JUN MAP2K1 MAPK3 MAPK8 NGF NGFR PIK3CA PIK3CG PIK3R1 PLCG1 RAF1 SHC1 SOS1 +BIOCARTA_NKCELLS_PATHWAY Ras-Independent pathway in NK cell-mediated cytotoxicity B2M HLA-A IL18 ITGB1 KLRC1 KLRC2 KLRC3 KLRC4 KLRD1 LAT MAP2K1 MAPK3 PAK1 PIK3CA PIK3R1 PTK2B PTPN6 RAC1 SYK VAV1 +BIOCARTA_NKT_PATHWAY Selective expression of chemokine receptors during T-cell polarization CCL3 CCL4 CCR1 CCR2 CCR3 CCR4 CCR5 CCR7 CD28 CD4 CD40LG CSF2 CXCR3 CXCR4 IFNG IFNGR1 IFNGR2 IL12A IL12B IL12RB1 IL12RB2 IL18R1 IL2 IL4 IL4R IL5 TGFB1 TGFB2 TGFB3 +BIOCARTA_NO1_PATHWAY Actions of Nitric Oxide in the Heart ACTA1 AKT1 BDKRB2 CALM1 CALM2 CALM3 CAV1 CHRM1 CHRNA1 CYCSP35 FLT1 FLT4 HSP90AA1 KDR KNG1 LOC124827 LOC147908 NOS3 PDE2A PDE3A PDE3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKG1 PRKG2 RYR2 SLC7A1 TNNI1 VEGFA +BIOCARTA_NO2IL12_PATHWAY NO2-dependent IL 12 Pathway in NK cells CCR5 CD2 CD247 CD3D CD3E CD3G CD4 CXCR3 IFNG IL12A IL12B IL12RB1 IL12RB2 JAK2 NOS2 STAT4 TYK2 +BIOCARTA_NOS1_PATHWAY Nitric Oxide Signaling Pathway CALM1 CALM2 CALM3 CYCSP35 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LOC124827 LOC147908 NOS1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB +BIOCARTA_NTHI_PATHWAY NFkB activation by Nontypeable Hemophilus influenzae CHUK CREBBP DUSP1 EP300 IKBKB IL1B IL8 MAP2K3 MAP2K6 MAP3K14 MAP3K7 MAPK11 MAPK14 MYD88 NFKB1 NFKBIA NR3C1 RELA SMAD3 SMAD4 TGFBR1 TGFBR2 TLR2 TNF +BIOCARTA_NUCLEARRS_PATHWAY Nuclear Receptors in Lipid Metabolism and Toxicity ABCB1 ABCB11 ABCB4 ABCC3 CYP1A2 CYP2E1 IDDM11 NR0B2 NR1H3 NR1H4 NR1I3 PPARA PPARD PPARG RARA +BIOCARTA_P27_PATHWAY Regulation of p27 Phosphorylation during Cell Cycle Progression CCNE1 CDK2 CDKN1B CKS1B CUL1 E2F1 NEDD8 RB1 RBX1 SKP1 SKP2 TFDP1 UBE2M +BIOCARTA_P35ALZHEIMERS_PATHWAY Deregulation of CDK5 in Alzheimers Disease APP CAPN1 CAPNS1 CAPNS2 CDK5 CDK5R1 CSNK1A1 CSNK1D GSK3B MAPT PPP2CA +BIOCARTA_P38MAPK_PATHWAY p38 MAPK Signaling Pathway ATF2 CDC42 CREB1 DAXX DDIT3 ELK1 GRB2 HMGN1 HRAS HSPB1 HSPB2 MAP2K4 MAP2K6 MAP3K1 MAP3K5 MAP3K7 MAP3K9 MAPK14 MAPKAPK2 MAPKAPK5 MAX MEF2A MEF2BNB-MEF2B MEF2C MEF2D MKNK1 MYC PLA2G4A RAC1 RAPGEF2 RIPK1 RPS6KA5 SHC1 STAT1 TGFB1 TGFB2 TGFB3 TGFBR1 TRADD TRAF2 +BIOCARTA_P53_PATHWAY p53 Signaling Pathway APAF1 ATM BAX BCL2 CCND1 CCNE1 CDK2 CDK4 CDKN1A E2F1 GADD45A MDM2 PCNA RB1 TIMP3 TP53 +BIOCARTA_P53HYPOXIA_PATHWAY Hypoxia and p53 in the Cardiovascular system ABCB1 AKT1 ATM BAX CDKN1A CSNK1A1 CSNK1D DNAJB1P1 EP300 FHL2 GADD45A HIC1 HIF1A HSP90AA1 HSPA1A IGFBP3 MAPK8 MDM2 NFKBIB NQO1 RPA1 TAF1 TP53 +BIOCARTA_PAR1_PATHWAY Thrombin signaling and protease-activated receptors ADCY1 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 F2 F2R F2RL3 GNA12 GNA13 GNAI1 GNAQ GNB1 GNGT1 MAP3K7 PIK3CA PIK3CG PIK3R1 PLCB1 PPP1R12B PRKCA PRKCB PTK2B RHOA ROCK1 +BIOCARTA_PARKIN_PATHWAY Role of Parkin in the Ubiquitin-Proteasomal Pathway GPR37 LOC93486 PARK2 SEPT5 SNCA SNCAIP SUMO1 UBE2E2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2L6 +BIOCARTA_PDGF_PATHWAY PDGF Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS JAK1 JUN MAP2K1 MAP2K4 MAP3K1 MAPK3 MAPK8 PDGFA PDGFRA PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB RAF1 RASA1 SHC1 SOS1 SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 +BIOCARTA_PGC1A_PATHWAY Regulation of PGC-1a CALM1 CALM2 CALM3 CAMK1 CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CYCSP35 ESRRA HDAC5 LOC124827 LOC147908 MEF2A MEF2BNB-MEF2B MEF2C MEF2D PPARA PPARGC1A PPP3CA PPP3CB PPP3CC SLC2A4 YWHAH +BIOCARTA_PITX2_PATHWAY Multi-step Regulation of Transcription by Pitx2 APC AXIN1 CREBBP CTNNB1 DVL1 EP300 FZD1 GSK3B HDAC1 LDB1 LEF1 MED1 PITX2 TRRAP WNT1 +BIOCARTA_PLATELETAPP_PATHWAY Platelet Amyloid Precursor Protein Pathway APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F11 F2 F9 PLAT PLAU PLG SERPINE1 +BIOCARTA_PLCE_PATHWAY Phospholipase C-epsilon pathway ADCY1 ADRB2 GNAS PLCE1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTGER1 RAP2B +BIOCARTA_PML_PATHWAY Regulation of transcriptional activity by PML CREBBP DAXX FAS FASLG HRAS PAX3 PML PRAM1 RARA RB1 SIRT1 SP100 SUMO1 TNF TNFRSF1A TNFRSF1B TP53 +BIOCARTA_PPARA_PATHWAY Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) ACOX1 APOA1 APOA2 CD36 CITED2 CPT1B CREBBP DUSP1 DUT EHHADH EP300 FABP1 FAT1 FRA8B HSD17B4 HSP90AA1 HSPA1A INS JUN LPL MAPK1 MAPK3 ME1 MED1 MRPL11 MYC NCOA1 NCOR1 NCOR2 NFKBIA NOS2 NR0B2 NR1H3 NR2F1 NRIP1 PDGFA PIK3CA PIK3CG PIK3R1 PPARA PPARGC1A PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PTGS2 RB1 RELA RXRA SP1 SRA1 STAT5A STAT5B TNF +BIOCARTA_PROTEASOME_PATHWAY Proteasome Complex PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC2 PSMC3 PSMC4 PSMC6 PSMD11 PSMD12 PSMD14 PSMD6 PSMD8 RPN1 RPN2 UBA1 UBE2A UBE3A +BIOCARTA_PS1_PATHWAY Presenilin action in Notch and Wnt signaling ADAM17 APC AXIN1 BTRC CTNNB1 DLL1 DVL1 FZD1 GSK3B HNF1A NOTCH1 PSEN1 RBPJ WNT1 +BIOCARTA_PTC1_PATHWAY Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle CCNB1 CCNH CDC25A CDC25B CDC25C CDK1 CDK7 MNAT1 PTCH1 SHH XPO1 +BIOCARTA_PTDINS_PATHWAY Phosphoinositides and their downstream targets. AKT1 AP2A1 AP2M1 ARF1 ARHGEF2 BAD BTK EEA1 GSK3A GSK3B JAG1 LYN PDPK1 PFKL PFKM PFKP PLCG1 PRKCE PRKCZ RAB5A RAC1 RPS6KB1 VAV2 +BIOCARTA_PTEN_PATHWAY PTEN dependent cell cycle arrest and apoptosis AKT1 BCAR1 CDKN1B FASLG FOXO3 GRB2 ILK ITGB1 MAPK1 MAPK3 PDK2 PDPK1 PIK3CA PIK3R1 PTEN PTK2 SHC1 SOS1 +BIOCARTA_PYK2_PATHWAY Links between Pyk2 and Map Kinases BCAR1 CALM1 CALM2 CALM3 CRKL CYCSP35 GNAQ GRB2 HRAS JUN LOC124827 LOC147908 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP3K1 MAPK1 MAPK14 MAPK3 MAPK8 PAK1 PLCG1 PRKCA PRKCB PTK2B RAC1 RAF1 SHC1 SOS1 SRC +BIOCARTA_RAB_PATHWAY Rab GTPases Mark Targets In The Endocytotic Machinery ACTA1 RAB11A RAB1A RAB27A RAB2A RAB3A RAB4A RAB5A RAB6A RAB7A RAB8A RAB9A +BIOCARTA_RAC1_PATHWAY Rac 1 cell motility signaling pathway ARFIP2 CDK5 CDK5R1 CFL1 CHN1 LIMK1 MAP3K1 MYL2 MYLK NCF2 PAK1 PDGFRA PIK3CA PIK3CG PIK3R1 PLD1 PPP1R12B RAC1 RALBP1 RPS6KB1 TRIO VAV1 WASF1 +BIOCARTA_RACCYCD_PATHWAY Influence of Ras and Rho proteins on G1 to S Transition AKT1 CCND1 CCNE1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CHUK E2F1 HRAS IKBKB IKBKG MAPK1 MAPK3 NFKB1 NFKBIA PAK1 PIK3CA PIK3R1 RAC1 RAF1 RB1 RELA RHOA TFDP1 +BIOCARTA_RANKL_PATHWAY Bone Remodelling EIF2AK2 FOS FOSL1 FOSL2 IFNAR1 IFNAR2 IFNB1 IRF9 MAPK8 NFKB1 RELA TNFRSF11A TNFSF11 TRAF6 +BIOCARTA_RANMS_PATHWAY Role of Ran in mitotic spindle regulation AURKA KIF15 KPNA2 KPNB1 NUMA1 RAN RANBP1 RANGAP1 RCC1 TPX2 +BIOCARTA_RARRXR_PATHWAY Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells ERCC3 GTF2A1 GTF2B GTF2E1 GTF2F1 HDAC3 KAT2B NCOA1 NCOA2 NCOA3 NCOR2 POLR2A RARA RXRA TBP +BIOCARTA_RAS_PATHWAY Ras Signaling Pathway AKT1 BAD BCL2L1 CASP9 CDC42 CHUK ELK1 FOXO4 HRAS MAP2K1 MAPK3 NFKB1 PIK3CA PIK3CG PIK3R1 PLD1 RAC1 RAF1 RALA RALBP1 RALGDS RELA RHOA +BIOCARTA_RB_PATHWAY RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage ATM CDC25B CDC25C CDK1 CDK2 CDK4 CHEK1 MAPK14 MYT1 RB1 TP53 WEE1 YWHAH +BIOCARTA_RELA_PATHWAY Acetylation and Deacetylation of RelA in The Nucleus CHUK CREBBP EP300 FADD HDAC3 IKBKB IKBKG NFKB1 NFKBIA RELA RIPK1 TNF TNFRSF1A TNFRSF1B TRADD TRAF6 +BIOCARTA_RHO_PATHWAY Rho cell motility signaling pathway ACTR2 ACTR3 ARHGAP1 ARHGAP4 ARHGAP5 ARHGAP6 ARHGEF1 ARHGEF11 ARHGEF5 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 CFL1 DIAPH1 GSN LIMK1 MYL2 MYLK OPHN1 PFN1 PIP5K1A PIP5K1B PPP1R12B RHOA ROCK1 SRC TLN1 VCL +BIOCARTA_RNA_PATHWAY Double Stranded RNA Induced Gene Expression CHUK DNAJC3 EIF2AK2 EIF2S1 EIF2S2 MAP3K14 NFKB1 NFKBIA RELA TP53 +BIOCARTA_SALMONELLA_PATHWAY How does salmonella hijack a cell ACTA1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 RAC1 WASF1 WASL +BIOCARTA_SARS_PATHWAY The SARS-coronavirus Life Cycle ANPEP CKM EIF4E FBL GPT LDHA LDHB LDHC MAPK14 NCL +BIOCARTA_SET_PATHWAY Granzyme A mediated Apoptosis Pathway ANP32A APEX1 CREBBP DFFA DFFB GZMA GZMB HMGB2 NME1 PRF1 SET +BIOCARTA_SHH_PATHWAY Sonic Hedgehog (Shh) Pathway DYRK1A DYRK1B GLI1 GLI2 GLI3 GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTCH1 SHH SMO SUFU +BIOCARTA_SKP2E2F_PATHWAY E2F1 Destruction Pathway CCNA1 CCNE1 CDC34 CDK2 CUL1 E2F1 RB1 SKP1 SKP2 TFDP1 +BIOCARTA_SODD_PATHWAY SODD/TNFR1 Signaling Pathway BAG4 BIRC3 CASP8 FADD RIPK1 TNF TNFRSF1A TNFRSF1B TRADD TRAF2 +BIOCARTA_SPPA_PATHWAY Aspirin Blocks Signaling Pathway Involved in Platelet Activation F2 F2R F2RL3 GNAI1 GNB1 GNGT1 HRAS ITGA1 ITGB1 MAP2K1 MAPK1 MAPK3 PLA2G4A PLCB1 PRKCA PRKCB PTGS1 PTK2 RAF1 SRC SYK TBXAS1 +BIOCARTA_SPRY_PATHWAY Sprouty regulation of tyrosine kinase signals CBL EGF EGFR GRB2 HRAS MAP2K1 MAPK1 MAPK3 PTPRB RAF1 RASA1 SHC1 SOS1 SPRY1 SPRY2 SPRY3 SPRY4 SRC +BIOCARTA_SRCRPTP_PATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1 CDC25A CDC25B CDC25C CDK1 CSK GRB2 PRKCA PRKCB PTPRA SRC +BIOCARTA_STATHMIN_PATHWAY Stathmin and breast cancer resistance to antimicrotubule agents CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CCNB1 CD2 CD247 CD3D CD3E CD3G CDK1 MAPK13 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +BIOCARTA_STEM_PATHWAY Regulation of hematopoiesis by cytokines CD4 CD8A CSF1 CSF2 CSF3 EPO IL11 IL2 IL3 IL4 IL5 IL6 IL7 IL8 IL9 +BIOCARTA_STRESS_PATHWAY TNF/Stress Related Signaling ATF1 CASP2 CHUK CRADD IKBKB IKBKG JUN LTA MAP2K3 MAP2K4 MAP2K6 MAP3K1 MAP3K14 MAP4K2 MAPK14 MAPK8 NFKB1 NFKBIA RELA RIPK1 TANK TNF TNFRSF1A TRADD TRAF2 +BIOCARTA_TALL1_PATHWAY TACI and BCMA stimulation of B cell immune responses. CHUK MAP3K14 MAPK14 MAPK8 NFKB1 RELA TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13 TNFSF13B TRAF2 TRAF3 TRAF5 TRAF6 +BIOCARTA_TCAPOPTOSIS_PATHWAY HIV Induced T Cell Apoptosis CCR5 CD247 CD28 CD3D CD3E CD3G CD4 FAS FASLG TRA@ TRB@ +BIOCARTA_TCR_PATHWAY T Cell Receptor Signaling Pathway CALM1 CALM2 CALM3 CD247 CD3D CD3E CD3G CYCSP35 ELK1 FOS FYN GRB2 HRAS JUN LAT LCK LOC124827 LOC147908 MAP2K1 MAP2K4 MAP3K1 MAPK3 MAPK8 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA PIK3CA PIK3CG PIK3R1 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB PTPN7 RAC1 RAF1 RASA1 RELA SHC1 SOS1 TRA@ TRB@ VAV1 ZAP70 +BIOCARTA_TCRA_PATHWAY Lck and Fyn tyrosine kinases in initiation of TCR Activation CD247 CD3D CD3E CD3G CD4 FYN HLA-DRA HLA-DRB1 LCK PTPRC TRA@ TRB@ ZAP70 +BIOCARTA_TCYTOTOXIC_PATHWAY T Cytotoxic Cell Surface Molecules CD2 CD247 CD28 CD3D CD3E CD3G CD8A ICAM1 ITGAL ITGB2 PTPRC THY1 TRA@ TRB@ +BIOCARTA_TEL_PATHWAY Telomeres, Telomerase, Cellular Aging, and Immortality AKT1 BCL2 EGFR HSP90AA1 IGF1R KRAS MYC POLR2A PPP2CA PRKCA RB1 TEP1 TERF1 TERT TNKS TP53 XRCC5 XRCC6 +BIOCARTA_TFF_PATHWAY Trefoil Factors Initiate Mucosal Healing AKT1 APAF1 BAD CASP9 CTNNB1 CYCS EGFR GH1 GHR GRB2 HRAS ITGB1 MAPK1 MAPK3 PIK3CA PIK3CG PIK3R1 PTK2 RHOA SHC1 SOS1 +BIOCARTA_TGFB_PATHWAY TGF beta signaling pathway APC CDH1 CREBBP EP300 MAP2K1 MAP3K7 MAPK3 SKIL SMAD2 SMAD3 SMAD4 SMAD7 TAB1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 ZFYVE9 +BIOCARTA_TH1TH2_PATHWAY Th1/Th2 Differentiation CD28 CD40 CD40LG CD86 HLA-DRA HLA-DRB1 IFNG IFNGR1 IFNGR2 IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IL2 IL2RA IL4 IL4R +BIOCARTA_THELPER_PATHWAY T Helper Cell Surface Molecules CD2 CD247 CD28 CD3D CD3E CD3G CD4 ICAM1 ITGAL ITGB2 PTPRC THY1 TRA@ TRB@ +BIOCARTA_TID_PATHWAY Chaperones modulate interferon Signaling Pathway DNAJA3 HSPA1A IFNG IFNGR1 IFNGR2 IKBKB JAK2 LIN7A NFKB1 NFKBIA RB1 RELA TAX1BP3 TNF TNFRSF1A TNFRSF1B TP53 USH1C WT1 +BIOCARTA_TNFR1_PATHWAY TNFR1 Signaling Pathway ARHGDIB BAG4 CASP2 CASP3 CASP8 CRADD DFFA DFFB FADD JUN LMNA LMNB1 LMNB2 MADD MAP2K4 MAP3K1 MAP3K7 MAPK8 PAK1 PAK2 PARP1 PRKDC RB1 RIPK1 SPTAN1 TNF TNFRSF1A TRADD TRAF2 +BIOCARTA_TNFR2_PATHWAY TNFR2 Signaling Pathway CHUK DUSP1 IKBKAP IKBKB IKBKG LTA MAP3K1 MAP3K14 NFKB1 NFKBIA RELA RIPK1 TANK TNFAIP3 TNFRSF1B TRAF1 TRAF2 TRAF3 +BIOCARTA_TOB1_PATHWAY Role of Tob in T-cell activation CD247 CD28 CD3D CD3E CD3G IFNG IL2 IL2RA IL4 SMAD3 SMAD4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TOB1 TOB2 TRA@ TRB@ +BIOCARTA_TOLL_PATHWAY Toll-Like Receptor Pathway CD14 CHUK ECSIT EIF2AK2 ELK1 FOS IKBKB IKBKG IRAK1 JUN LY96 MAP2K3 MAP2K4 MAP2K6 MAP3K1 MAP3K14 MAP3K7 MAPK14 MAPK8 MYD88 NFKB1 NFKBIA PGLYRP1 PPARA RELA TAB1 TAB2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR6 TLR7 TLR9 TOLLIP TRAF6 +BIOCARTA_TPO_PATHWAY TPO Signaling Pathway CSNK2A1 FOS GRB2 HRAS JAK2 JUN MAP2K1 MAPK3 MPL PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB RAF1 RASA1 SHC1 SOS1 STAT1 STAT3 STAT5A STAT5B THPO +BIOCARTA_TRKA_PATHWAY Trka Receptor Signaling Pathway AKT1 GRB2 HRAS NGF NTRK1 PIK3CA PIK3R1 PLCG1 PRKCA PRKCB SHC1 SOS1 +BIOCARTA_UCALPAIN_PATHWAY uCalpain and friends in Cell spread ACTA1 ACTN1 ACTN2 ACTN3 CAPN1 CAPNS1 CAPNS2 EZR ITGA1 ITGB1 ITGB3 PTK2 PXN RAC1 RHOA SPTAN1 SRC TLN1 +BIOCARTA_VDR_PATHWAY Control of Gene Expression by Vitamin D Receptor CARM1 CREBBP EP300 HDAC1 KAT2B MED1 NCOA1 NCOA2 NCOA3 NCOR1 RXRA TSC2 +BIOCARTA_VEGF_PATHWAY VEGF, Hypoxia, and Angiogenesis ARNT EIF1 EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 ELAVL1 FLT1 FLT4 HIF1A HRAS KDR NOS3 PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB PTK2 PXN SHC1 VEGFA VHL +BIOCARTA_VIP_PATHWAY Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells CALM1 CALM2 CALM3 CHUK CYCSP35 EGR2 EGR3 GNAQ LOC124827 LOC147908 MAP3K1 MYC NFATC1 NFATC2 NFKB1 NFKBIA PLCG1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RELA VIP VIPR2 +BIOCARTA_VITCB_PATHWAY Vitamin C in the Brain COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 P4HB SLC23A1 SLC23A2 SLC2A1 SLC2A3 +BIOCARTA_WNT_PATHWAY WNT Signaling Pathway APC AXIN1 BTRC CCND1 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTBP1 CTNNB1 DVL1 FRAT1 FZD1 GSK3B HDAC1 LEF1 MAP3K7 MYC NLK PPARD PPP2CA SMAD4 TAB1 TLE1 WIF1 WNT1 +KEGG_ABC_TRANSPORTERS ABC transporters ABCA1 ABCA10 ABCA12 ABCA13 ABCA2 ABCA3 ABCA4 ABCA5 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB11 ABCB4 ABCB5 ABCB6 ABCB7 ABCB8 ABCB9 ABCC1 ABCC10 ABCC11 ABCC12 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 ABCD2 ABCD3 ABCD4 ABCG1 ABCG2 ABCG4 ABCG5 ABCG8 CFTR TAP1 TAP2 +KEGG_ACUTE_MYELOID_LEUKEMIA Acute myeloid leukemia AKT1 AKT2 AKT3 ARAF BAD BRAF CCNA1 CCND1 CEBPA CHUK EIF4EBP1 FLT3 GRB2 HRAS IKBKB IKBKG JUP KIT KRAS LEF1 LOC652346 LOC652671 LOC652799 MAP2K1 MAP2K2 MAPK1 MAPK3 MTOR MYC NFKB1 NRAS PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIM1 PIM2 PML PPARD RAF1 RARA RELA RPS6KB1 RPS6KB2 RUNX1 RUNX1T1 SOS1 SOS2 SPI1 STAT3 STAT5A STAT5B TCF7 TCF7L1 TCF7L2 ZBTB16 +KEGG_ADHERENS_JUNCTION Adherens junction ACP1 ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 BAIAP2 CDC42 CDH1 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 EGFR EP300 ERBB2 FARP2 FER FGFR1 FYN IGF1R INSR IQGAP1 LEF1 LMO7 LOC100418883 LOC646821 MAP3K7 MAPK1 MAPK3 MET MLLT4 NLK PARD3 PTPN1 PTPN6 PTPRB PTPRF PTPRJ PTPRM PVRL1 PVRL2 PVRL3 PVRL4 RAC1 RAC2 RAC3 RHOA SMAD2 SMAD3 SMAD4 SNAI1 SNAI2 SORBS1 SRC SSX2IP TCF7 TCF7L1 TCF7L2 TGFBR1 TGFBR2 TJP1 VCL WAS WASF1 WASF2 WASF3 WASL YES1 +KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY Adipocytokine signaling pathway ACACB ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ADIPOQ ADIPOR1 ADIPOR2 AGRP AKT1 AKT2 AKT3 CAMKK1 CAMKK2 CD36 CHUK CPT1A CPT1B CPT1C G6PC G6PC2 IKBKB IKBKG IRS1 IRS2 IRS4 JAK2 LEP LEPR MAPK10 MAPK8 MAPK9 MTOR NFKB1 NFKBIA NFKBIB NFKBIE NPY PCK1 PCK2 POMC PPARA PPARGC1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKCQ PTPN11 RELA RXRA RXRB RXRG SLC2A1 SLC2A4 SOCS3 STAT3 STK11 TNF TNFRSF1A TNFRSF1B TRADD TRAF2 +KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM Alanine, aspartate and glutamate metabolism ABAT ACY3 ADSL ADSS ADSSL1 AGXT AGXT2 ALDH4A1 ALDH5A1 ASL ASNS ASPA ASS1 CAD CPS1 DDO GAD1 GAD2 GFPT1 GFPT2 GLS GLS2 GLUD1 GLUD2 GLUL GOT1 GOT2 GPT GPT2 IL4I1 NIT2 PPAT +KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION Aldosterone-regulated sodium reabsorption ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4 FXYD2 FXYD4 HSD11B1 HSD11B2 IGF1 INS INSR IRS1 IRS2 IRS4 KCNJ1 KRAS MAPK1 MAPK3 NEDD4L NR3C2 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PRKCA PRKCB PRKCG SCNN1A SCNN1B SCNN1G SFN SGK1 SLC9A3R2 +KEGG_ALLOGRAFT_REJECTION Allograft rejection CD28 CD40 CD40LG CD80 CD86 FAS FASLG GZMB HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G IFNG IL10 IL12A IL12B IL2 IL4 IL5 LOC652614 PRF1 TNF +KEGG_ALPHA_LINOLENIC_ACID_METABOLISM alpha-Linolenic acid metabolism ACOX1 ACOX3 FADS2 JMJD7-PLA2G4B PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 +KEGG_ALZHEIMERS_DISEASE Alzheimer's disease ADAM10 ADAM17 APAF1 APBB1 APH1A APOE APP ATF6 ATP2A1 ATP2A2 ATP2A3 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G1P5 ATP5G2 ATP5G3 ATP5H ATP5J ATP5O ATP6 ATP8 BACE1 BACE2 BAD BID CACNA1C CACNA1D CACNA1F CACNA1S CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAPN1 CAPN2 CASP3 CASP7 CASP8 CASP9 CDK5 CDK5R1 CHP CHP2 COX1 COX2 COX3 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX6CP3 COX7A1 COX7A2 COX7A2L COX7B COX7B2 COX7C COX8A COX8C CYC1 CYCS CYTB EIF2AK3 ERN1 FADD FAS GAPDH GNAQ GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GSK3B HSD17B10 IDE IL1B ITPR1 ITPR2 ITPR3 LOC100133737 LOC642502 LOC644310 LOC727947 LPL LRP1 MAPK1 MAPK3 MAPT MME NAE1 NCSTN NDUFA1 NDUFA10 NDUFA2 NDUFA3 NDUFA4 NDUFA4L2 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NOS1 PLCB1 PLCB2 PLCB3 PLCB4 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PSEN1 PSEN2 PSENEN RYR3 SDHA SDHB SDHC SDHD SNCA TNF TNFRSF1A UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM Amino sugar and nucleotide sugar metabolism AMDHD2 CHIA CHIT1 CMAS CYB5R1 CYB5R3 FPGT FUK GALE GALK1 GALK2 GALT GCK GFPT1 GFPT2 GMDS GMPPA GMPPB GNE GNPDA1 GNPDA2 GNPNAT1 GPI HEXA HEXB HK1 HK2 HK3 MPI NAGK NANP NANS NPL PGM1 PGM2 PGM3 PMM1 PMM2 RENBP TSTA3 UAP1 UGDH UGP2 UXS1 +KEGG_AMINOACYL_TRNA_BIOSYNTHESIS Aminoacyl-tRNA biosynthesis AARS AARS2 CARS CARS2 DARS DARS2 EARS2 EPRS FARS2 FARSA FARSB GARS HARS HARS2 IARS IARS2 KARS LARS LARS2 MARS MARS2 MTFMT NARS NARS2 PARS2 PSTK QARS RARS RARS2 SARS SARS2 SEPSECS TARS TARS2 TARSL2 VARS VARS2 WARS WARS2 YARS YARS2 +KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS Amyotrophic lateral sclerosis (ALS) ALS2 APAF1 BAD BAX BCL2 BCL2L1 BID CASP1 CASP3 CASP9 CAT CCS CHP CHP2 CYCS DAXX DERL1 GPX1 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D MAP2K3 MAP2K6 MAP3K5 MAPK11 MAPK12 MAPK13 MAPK14 NEFH NEFL NEFM NOS1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRPH PRPH2 RAB5A RAC1 SLC1A2 SOD1 TNF TNFRSF1A TNFRSF1B TOMM40 TOMM40L TP53 +KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION Antigen processing and presentation B2M CALR CANX CD4 CD74 CD8A CD8B CIITA CREB1 CTSB CTSL1 CTSS HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA5 HSPA6 HSPA8 IFI30 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DL5A KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DL2 KIR3DL3 KLRC1 KLRC2 KLRC3 KLRC4 KLRD1 LGMN LOC652614 LTA NFYA NFYB NFYC PDIA3 PSME1 PSME2 PSME3 RFX5 RFXANK RFXAP TAP1 TAP2 TAPBP +KEGG_APOPTOSIS Apoptosis AIFM1 AKT1 AKT2 AKT3 APAF1 ATM BAD BAX BCL2 BCL2L1 BID BIRC2 BIRC3 CAPN1 CAPN2 CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CFLAR CHP CHP2 CHUK CSF2RB CYCS DFFA DFFB ENDOD1 ENDOG EXOG FADD FAS FASLG IKBKB IKBKG IL1A IL1B IL1R1 IL1RAP IL3 IL3RA IRAK1 IRAK2 IRAK3 IRAK4 LOC651610 MAP3K14 MYD88 NFKB1 NFKBIA NGF NTRK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX RELA RIPK1 TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF1A TNFSF10 TP53 TRADD TRAF2 XIAP +KEGG_ARACHIDONIC_ACID_METABOLISM Arachidonic acid metabolism AKR1C3 ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 CBR1 CBR3 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2E1 CYP2J2 CYP2U1 CYP4A11 CYP4A22 CYP4F2 CYP4F3 EPHX2 GGT1 GGT5 GGT6 GGT7 GPX1 GPX2 GPX3 GPX4 GPX5 GPX6 GPX7 HPGDS JMJD7-PLA2G4B LTA4H LTC4S PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PTGDS PTGES PTGES2 PTGIS PTGS1 PTGS2 TBXAS1 +KEGG_ARGININE_AND_PROLINE_METABOLISM Arginine and proline metabolism ABP1 ACY1 ADC AGMAT ALDH18A1 ALDH1B1 ALDH2 ALDH3A2 ALDH4A1 ALDH7A1 ALDH9A1 AMD1 ARG1 ARG2 ASL ASS1 CKB CKM CKMT1A CKMT1B CKMT2 CPS1 DAO GAMT GATM GLS GLS2 GLUD1 GLUD2 GLUL GOT1 GOT2 LAP3 MAOA MAOB NAGS NOS1 NOS2 NOS3 OAT ODC1 OTC P4HA1 P4HA2 P4HA3 PRODH PRODH2 PYCR1 PYCR2 PYCRL SAT1 SAT2 SMS SRM +KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC Arrhythmogenic right ventricular cardiomyopathy (ARVC) ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 ATP2A2 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CDH2 CTNNA1 CTNNA2 CTNNA3 CTNNB1 DAG1 DES DMD DSC2 DSG2 DSP EMD GJA1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUP LAMA2 LEF1 LMNA LOC100418883 LOC646821 PKP2 RYR2 SGCA SGCB SGCD SGCG SLC8A1 TCF7 TCF7L1 TCF7L2 +KEGG_ASCORBATE_AND_ALDARATE_METABOLISM Ascorbate and aldarate metabolism ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 MIOX UGDH UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +KEGG_ASTHMA Asthma CCL11 CD40 CD40LG EPX FCER1A FCER1G HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL10 IL13 IL3 IL4 IL5 IL9 MS4A2 PRG2 RNASE3 TNF +KEGG_AUTOIMMUNE_THYROID_DISEASE Autoimmune thyroid disease CD28 CD40 CD40LG CD80 CD86 CGA CTLA4 FAS FASLG GZMB HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IL10 IL2 IL4 IL5 LOC652614 PRF1 TG TPO TSHB TSHR +KEGG_AXON_GUIDANCE Axon guidance ABL1 ABLIM1 ABLIM2 ABLIM3 ARHGEF12 CDC42 CDK5 CFL1 CFL2 CHP CHP2 CXCL12 CXCR4 DCC DPYSL2 DPYSL5 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FES FYN GNAI1 GNAI2 GNAI3 GSK3B HRAS ITGB1 KRAS L1CAM LIMK1 LIMK2 LRRC4C MAPK1 MAPK3 MET NCK1 NCK2 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NGEF NRAS NRP1 NTN1 NTN3 NTN4 NTNG1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PLXNA1 PLXNA2 PLXNA3 PLXNB1 PLXNB2 PLXNB3 PLXNC1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PTK2 RAC1 RAC2 RAC3 RASA1 RGS3 RHOA RHOD RND1 ROBO1 ROBO2 ROBO3 ROCK1 ROCK2 SEMA3A SEMA3B SEMA3C SEMA3D SEMA3E SEMA3F SEMA3G SEMA4A SEMA4B SEMA4C SEMA4D SEMA4F SEMA4G SEMA5A SEMA5B SEMA6A SEMA6B SEMA6C SEMA6D SEMA7A SLIT1 SLIT2 SLIT3 SRGAP1 SRGAP2 SRGAP3 UNC5A UNC5B UNC5C UNC5D +KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY B cell receptor signaling pathway AKT1 AKT2 AKT3 BCL10 BLNK BTK CARD11 CD19 CD22 CD72 CD79A CD79B CD81 CHP CHP2 CHUK CR2 DAPP1 FCGR2B FOS GRB2 GSK3B HRAS IFITM1 IKBKB IKBKG INPP5D JUN KRAS LILRB3 LYN MALT1 MAP2K1 MAP2K2 MAPK1 MAPK3 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCB PTPN6 RAC1 RAC2 RAC3 RAF1 RASGRP3 RELA SOS1 SOS2 SYK VAV1 VAV2 VAV3 +KEGG_BASAL_CELL_CARCINOMA Basal cell carcinoma APC APC2 AXIN1 AXIN2 BMP2 BMP4 CTNNB1 DVL1 DVL2 DVL3 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GLI1 GLI2 GLI3 GSK3B HHIP LEF1 PTCH1 PTCH2 SHH SMO STK36 SUFU TCF7 TCF7L1 TCF7L2 TP53 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +KEGG_BASAL_TRANSCRIPTION_FACTORS Basal transcription factors GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2I GTF2IRD1 LOC391764 STON1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1L TAF2 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF7L TAF9 TAF9B TBP TBPL1 TBPL2 +KEGG_BASE_EXCISION_REPAIR Base excision repair APEX1 APEX2 FEN1 HMGB1 HMGB1P1 HMGB1P40 LIG1 LIG3 MBD4 MPG MUTYH NEIL1 NEIL2 NEIL3 NTHL1 OGG1 PARP1 PARP2 PARP3 PARP4 PCNA POLB POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLL SMUG1 TDG UNG XRCC1 +KEGG_BETA_ALANINE_METABOLISM beta-Alanine metabolism ABAT ACADM ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 AOC2 AOC3 CNDP1 DPYD DPYS ECHS1 EHHADH GAD1 GAD2 HADHA HIBCH MLYCD SMS SRM UPB1 +KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS Biosynthesis of unsaturated fatty acids ACAA1 ACOT1 ACOT2 ACOT4 ACOT7 ACOX1 ACOX3 BAAT ELOVL2 ELOVL5 ELOVL6 FADS1 FADS2 HADHA HSD17B12 PECR PTPLA PTPLB SCD SCD5 TECR YOD1 +KEGG_BLADDER_CANCER Bladder cancer ARAF BRAF CCND1 CDH1 CDK4 CDKN1A CDKN2A DAPK1 DAPK2 DAPK3 E2F1 E2F2 E2F3 EGF EGFR ERBB2 FGFR3 FIGF HRAS IL8 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MDM2 MMP1 MMP2 MMP9 MYC NRAS PGF RAF1 RASSF1 RB1 RPS6KA5 THBS1 TP53 TYMP VEGFA VEGFB VEGFC +KEGG_BUTANOATE_METABOLISM Butanoate metabolism AACS ABAT ACADS ACAT1 ACAT2 ACSM1 ACSM2A ACSM3 ACSM4 ACSM5 AKR1B10 ALDH1B1 ALDH2 ALDH3A2 ALDH5A1 ALDH7A1 ALDH9A1 BDH1 BDH2 ECHS1 EHHADH GAD1 GAD2 HADH HADHA HMGCL HMGCS1 HMGCS2 L2HGDH OXCT1 OXCT2 PDHA1 PDHA2 PDHB +KEGG_CALCIUM_SIGNALING_PATHWAY Calcium signaling pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY7 ADCY8 ADCY9 ADORA2A ADORA2B ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 AGTR1 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 AVPR1A AVPR1B BDKRB1 BDKRB2 BST1 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CCKAR CCKBR CD38 CHP CHP2 CHRM1 CHRM2 CHRM3 CHRM5 CHRNA7 CYSLTR1 CYSLTR2 DRD1 DRD5 EDNRA EDNRB EGFR ERBB2 ERBB3 ERBB4 F2R GNA11 GNA14 GNA15 GNAL GNAQ GNAS GRIN1 GRIN2A GRIN2C GRIN2D GRM1 GRM5 GRPR HRH1 HRH2 HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 ITPKA ITPKB ITPR1 ITPR2 ITPR3 LHCGR LOC729317 LTB4R2 MYLK MYLK2 MYLK3 NOS1 NOS2 NOS3 NTSR1 OXTR P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 PDE1A PDE1B PDE1C PDGFRA PDGFRB PHKA1 PHKA2 PHKB PHKG1 PHKG2 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PLN PPID PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX PTAFR PTGER1 PTGER3 PTGFR PTK2B RYR1 RYR2 RYR3 SLC25A31 SLC25A4 SLC25A5 SLC25A6 SLC8A1 SLC8A2 SLC8A3 SPHK1 SPHK2 TACR1 TACR2 TACR3 TBXA2R TNNC1 TNNC2 TRHR TRPC1 VDAC1 VDAC2 VDAC3 +KEGG_CARDIAC_MUSCLE_CONTRACTION Cardiac muscle contraction ACTC1 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4 ATP2A2 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 COX1 COX2 COX3 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX6CP3 COX7A1 COX7A2 COX7A2L COX7B COX7B2 COX7C COX8A COX8C CYC1 CYTB FXYD2 LOC644310 LOC727947 MYH6 MYH7 MYL2 MYL3 RYR2 SLC8A1 SLC9A1 SLC9A6 TNNC1 TNNI3 TNNT2 TPM1 TPM2 TPM3 TPM4 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +KEGG_CELL_ADHESION_MOLECULES_CAMS Cell adhesion molecules (CAMs) ALCAM CADM1 CADM3 CD2 CD22 CD226 CD274 CD276 CD28 CD34 CD4 CD40 CD40LG CD58 CD6 CD80 CD86 CD8A CD8B CD99 CDH1 CDH15 CDH2 CDH3 CDH4 CDH5 CLDN1 CLDN10 CLDN11 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CNTN1 CNTN2 CNTNAP1 CNTNAP2 CTLA4 ESAM F11R GLG1 HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G ICAM1 ICAM2 ICAM3 ICOS ICOSLG ITGA4 ITGA6 ITGA8 ITGA9 ITGAL ITGAM ITGAV ITGB1 ITGB2 ITGB7 ITGB8 JAM2 JAM3 L1CAM LOC652614 MADCAM1 MAG MPZ MPZL1 NCAM1 NCAM2 NEGR1 NEO1 NFASC NLGN1 NLGN2 NLGN3 NLGN4X NRCAM NRXN1 NRXN2 NRXN3 OCLN PDCD1 PDCD1LG2 PECAM1 PTPRC PTPRF PTPRM PVR PVRL1 PVRL2 PVRL3 SDC1 SDC2 SDC3 SDC4 SELE SELL SELP SELPLG SIGLEC1 SPN VCAM1 VCAN +KEGG_CELL_CYCLE Cell cycle ABL1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ATM ATR BUB1 BUB1B BUB3 CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC14A CDC14B CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC27 CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CHEK1 CHEK2 CREBBP CUL1 DBF4 E2F1 E2F2 E2F3 E2F4 E2F5 EP300 ESPL1 FZR1 GADD45A GADD45B GADD45G GSK3B HDAC1 HDAC2 LOC650621 LOC651610 LOC728622 LOC731751 MAD1L1 MAD2L1 MAD2L2 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MDM2 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 PLK1 PRKDC PTTG1 PTTG2 RAD21 RB1 RBL1 RBL2 RBX1 SFN SKP1 SKP2 SMAD2 SMAD3 SMAD4 SMC1A SMC1B SMC3 STAG1 STAG2 TFDP1 TFDP2 TGFB1 TGFB2 TGFB3 TP53 TTK WEE1 WEE2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB17 +KEGG_CHEMOKINE_SIGNALING_PATHWAY Chemokine signaling pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 ADRBK2 AKT1 AKT2 AKT3 ARRB1 ARRB2 BCAR1 BRAF CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CDC42 CHUK CRK CRKL CSK CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DOCK2 ELMO1 FGR FOXO3 GNAI1 GNAI2 GNAI3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GRK1 GRK4 GRK5 GRK6 GRK7 GSK3A GSK3B HCK HRAS IKBKB IKBKG IL8 ITK JAK2 JAK3 KRAS LYN MAP2K1 MAPK1 MAPK3 NCF1 NFKB1 NFKBIA NFKBIB NRAS PAK1 PARD3 PF4 PF4V1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PPBP PPBPL1 PREX1 PRKACA PRKACB PRKACG PRKCB PRKCD PRKCZ PRKX PTK2 PTK2B PXN RAC1 RAC2 RAF1 RAP1A RAP1B RASGRP2 RELA RHOA ROCK1 ROCK2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 STAT1 STAT2 STAT3 STAT5B TIAM1 TIAM2 VAV1 VAV2 VAV3 WAS WASL XCL1 XCL2 XCR1 +KEGG_CHRONIC_MYELOID_LEUKEMIA Chronic myeloid leukemia ABL1 AKT1 AKT2 AKT3 ARAF BAD BCL2L1 BCR BRAF CBL CBLB CBLC CCND1 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CHUK CRK CRKL CTBP1 CTBP2 E2F1 E2F2 E2F3 GAB2 GRB2 HDAC1 HDAC2 HRAS IKBKB IKBKG KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MDM2 MECOM MYC NFKB1 NFKBIA NRAS PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTPN11 RAF1 RB1 RELA RUNX1 SHC1 SHC2 SHC3 SHC4 SMAD3 SMAD4 SOS1 SOS2 STAT5A STAT5B TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TP53 +KEGG_CIRCADIAN_RHYTHM_MAMMAL Circadian rhythm - mammal ARNTL BHLHE40 BHLHE41 CLOCK CRY1 CRY2 CSNK1D CSNK1E NPAS2 NR1D1 PER1 PER2 PER3 +KEGG_CITRATE_CYCLE_TCA_CYCLE Citrate cycle (TCA cycle) ACLY ACO1 ACO2 CS DLAT DLD DLST FH IDH1 IDH2 IDH3A IDH3B IDH3G LOC283398 LOC642502 MDH1 MDH2 OGDH OGDHL PC PCK1 PCK2 PDHA1 PDHA2 PDHB SDHA SDHB SDHC SDHD SUCLA2 SUCLG1 SUCLG2 +KEGG_COLORECTAL_CANCER Colorectal cancer AKT1 AKT2 AKT3 APC APC2 APPL1 ARAF AXIN1 AXIN2 BAD BAX BCL2 BIRC5 BRAF CASP3 CASP9 CCND1 CTNNB1 CYCS DCC FOS GSK3B JUN KRAS LEF1 MAP2K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MLH1 MSH2 MSH3 MSH6 MYC PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 RAC1 RAC2 RAC3 RAF1 RALGDS RHOA SMAD2 SMAD3 SMAD4 TCF7 TCF7L1 TCF7L2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TP53 +KEGG_COMPLEMENT_AND_COAGULATION_CASCADES Complement and coagulation cascades A2M BDKRB1 BDKRB2 C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4BPA C4BPB C5 C5AR1 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CFB CFD CFH CFI CPB2 CR1 CR2 F10 F11 F12 F13A1 F13B F2 F2R F3 F5 F7 F8 F9 FGA FGB FGG KLKB1 KNG1 MASP1 MASP2 MBL2 PLAT PLAU PLAUR PLG PROC PROS1 SERPINA1 SERPINA5 SERPINC1 SERPIND1 SERPINE1 SERPINF2 SERPING1 TFPI THBD VWF +KEGG_CYSTEINE_AND_METHIONINE_METABOLISM Cysteine and methionine metabolism ADI1 AHCY AHCYL1 AHCYL2 AMD1 APIP BHMT CBS CDO1 CTH DNMT1 DNMT3A DNMT3B DNMT3L ENOPH1 GOT1 GOT2 IL4I1 LDHA LDHAL6A LDHAL6B LDHB LDHC MAT1A MAT2A MAT2B MPST MTAP MTR SDS SMS SRM TAT TRDMT1 +KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Cytokine-cytokine receptor interaction ACVR1 ACVR1B ACVR2A ACVR2B ACVRL1 AMH AMHR2 BMP2 BMP7 BMPR1A BMPR1B BMPR2 CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CD27 CD40 CD40LG CD70 CLCF1 CNTF CNTFR CRLF2 CSF1 CSF1R CSF2 CSF2RA CSF2RB CSF3 CSF3R CTF1 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 EDA EDA2R EDAR EGF EGFR EPO EPOR FAS FASLG FIGF FLT1 FLT3 FLT3LG FLT4 GDF5 GH1 GH2 GHR HGF IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNE IFNG IFNGR1 IFNGR2 IFNK IFNW1 IL10 IL10RA IL10RB IL11 IL11RA IL12A IL12B IL12RB1 IL12RB2 IL13 IL13RA1 IL15 IL15RA IL17A IL17B IL17RA IL17RB IL18 IL18R1 IL18RAP IL19 IL1A IL1B IL1R1 IL1R2 IL1RAP IL2 IL20 IL20RA IL20RB IL21 IL21R IL22 IL22RA1 IL22RA2 IL23A IL23R IL24 IL25 IL26 IL28A IL28B IL28RA IL29 IL2RA IL2RB IL2RG IL3 IL3RA IL4 IL4R IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R IL8 IL9 IL9R INHBA INHBB INHBC INHBE KDR KIT KITLG LEP LEPR LIF LIFR LOC652799 LTA LTB LTBR MET MPL NGFR OSM OSMR PDGFA PDGFB PDGFC PDGFRA PDGFRB PF4 PF4V1 PLEKHO2 PPBP PPBPL1 PRL PRLR RELT TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11A TNFRSF11B TNFRSF12A TNFRSF13B TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFRSF4 TNFRSF6B TNFRSF8 TNFRSF9 TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 TPO TSLP VEGFA VEGFB VEGFC XCL1 XCL2 XCR1 +KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY Cytosolic DNA-sensing pathway ADAR AIM2 CASP1 CCL4 CCL4L1 CCL4L2 CCL5 CHUK CXCL10 DDX58 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IL18 IL1B IL33 IL6 IRF3 IRF7 MAVS NFKB1 NFKBIA NFKBIB POLR1C POLR1D POLR3A POLR3B POLR3C POLR3D POLR3F POLR3G POLR3GL POLR3H POLR3K PYCARD RELA RIPK1 RIPK3 TBK1 TMEM173 TREX1 ZBP1 +KEGG_DILATED_CARDIOMYOPATHY Dilated cardiomyopathy ACTB ACTC1 ACTG1 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB1 ATP2A2 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 DAG1 DES DMD EMD GNAS IGF1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 LAMA2 LMNA LOC100418883 LOC646821 MYBPC3 MYH6 MYH7 MYL2 MYL3 PLN PRKACA PRKACB PRKACG PRKX RYR2 SGCA SGCB SGCD SGCG SLC8A1 TGFB1 TGFB2 TGFB3 TNF TNNC1 TNNI3 TNNT2 TPM1 TPM2 TPM3 TPM4 TTN +KEGG_DNA_REPLICATION DNA replication DNA2 FEN1 LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RNASEH1 RNASEH2A RNASEH2B RNASEH2C RPA1 RPA2 RPA3 RPA4 SSBP1 +KEGG_DORSO_VENTRAL_AXIS_FORMATION Dorso-ventral axis formation CPEB1 EGFR ETS1 ETS2 ETV6 ETV7 FMN2 GRB2 KRAS LOC652554 MAP2K1 MAPK1 MAPK3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIWIL1 PIWIL2 PIWIL3 PIWIL4 SOS1 SOS2 SPIRE1 SPIRE2 +KEGG_DRUG_METABOLISM_CYTOCHROME_P450 Drug metabolism - cytochrome P450 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ALDH1A3 ALDH3A1 ALDH3B1 ALDH3B2 AOX1 CYP1A2 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 FMO1 FMO2 FMO3 FMO4 FMO5 GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTZ1 MAOA MAOB MGST1 MGST2 MGST3 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +KEGG_DRUG_METABOLISM_OTHER_ENZYMES Drug metabolism - other enzymes CDA CES1 CES2 CES5A CYP2A13 CYP2A6 CYP2A7 CYP3A4 CYP3A43 CYP3A5 CYP3A7 DPYD DPYS GMPS GUSB HPRT1 IMPDH1 IMPDH2 ITPA NAT1 NAT2 TK1 TK2 TPMT TYMP UCK1 UCK2 UCKL1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UMPS UPB1 UPP1 UPP2 XDH +KEGG_ECM_RECEPTOR_INTERACTION ECM-receptor interaction AGRN CD36 CD44 CD47 CHAD COL11A1 COL11A2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A4 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A6 COMP DAG1 FN1 GP1BA GP1BB GP5 GP6 GP9 HMMR HSPG2 IBSP ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 RELN SDC1 SDC2 SDC3 SDC4 SPP1 SV2A SV2B SV2C THBS1 THBS2 THBS3 THBS4 TNC TNN TNR TNXB VTN VWF +KEGG_ENDOCYTOSIS Endocytosis ACAP1 ACAP2 ACAP3 ADRB1 ADRB2 ADRB3 ADRBK1 ADRBK2 AGAP1 AGAP2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARAP1 ARAP2 ARAP3 ARF6 ARFGAP1 ARFGAP2 ARFGAP3 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 CBL CBLB CBLC CCR5 CDC42 CHMP1B CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CLTA CLTB CLTC CLTCL1 CSF1R CXCR1 CXCR2 CXCR4 DAB2 DNAJC6 DNM1 DNM1L DNM2 DNM3 EEA1 EGF EGFR EHD1 EHD2 EHD3 EHD4 EPN1 EPN2 EPN3 EPS15 ERBB3 ERBB4 F2R FAM125A FAM125B FGFR2 FGFR3 FGFR4 FLT1 GIT1 GIT2 GRK1 GRK4 GRK5 GRK6 GRK7 HGS HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HRAS HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IGF1R IL2RA IL2RB IL2RG IQSEC1 IQSEC2 IQSEC3 ITCH KDR KIT LDLR LDLRAP1 LOC652614 LOC652799 MDM2 MET NEDD4 NEDD4L NTRK1 PARD3 PARD6A PARD6B PARD6G PDCD6IP PDGFRA PIKFYVE PIP4K2B PIP5K1A PIP5K1B PIP5K1C PLD1 PLD2 PRKCI PRKCZ PSD PSD2 PSD3 PSD4 RAB11A RAB11B RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB22A RAB31 RAB4A RAB5A RAB5B RAB5C RABEP1 RET RNF41 RUFY1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SH3KBP1 SMAP1 SMAP2 SMURF1 SMURF2 SNF8 SRC STAM STAM2 STAMBP TFRC TRAF6 TSG101 USP8 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS45 VPS4A VPS4B VTA1 WWP1 ZFYVE20 +KEGG_ENDOMETRIAL_CANCER Endometrial cancer AKT1 AKT2 AKT3 APC APC2 ARAF AXIN1 AXIN2 BAD BRAF CASP9 CCND1 CDH1 CTNNA1 CTNNA2 CTNNA3 CTNNB1 EGF EGFR ELK1 ERBB2 FOXO3 GRB2 GSK3B HRAS ILK KRAS LEF1 MAP2K1 MAP2K2 MAPK1 MAPK3 MLH1 MYC NRAS PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTEN RAF1 SOS1 SOS2 TCF7 TCF7L1 TCF7L2 TP53 +KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Epithelial cell signaling in Helicobacter pylori infection ADAM10 ADAM17 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CASP3 CCL5 CDC42 CHUK CSK CXCL1 CXCR1 CXCR2 EGFR F11R GIT1 HBEGF IGSF5 IKBKB IKBKG IL8 JAM2 JAM3 JUN LYN MAP2K4 MAP3K14 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MET NFKB1 NFKBIA NOD1 PAK1 PLCG1 PLCG2 PTPN11 PTPRZ1 RAC1 RELA SRC TCIRG1 TJP1 +KEGG_ERBB_SIGNALING_PATHWAY ErbB signaling pathway ABL1 ABL2 AKT1 AKT2 AKT3 ARAF AREG BAD BRAF BTC CAMK2A CAMK2B CAMK2D CAMK2G CBL CBLB CBLC CDKN1A CDKN1B CRK CRKL EGF EGFR EIF4EBP1 ELK1 ERBB2 ERBB3 ERBB4 EREG GAB1 GRB2 GSK3B HBEGF HRAS JUN KRAS MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MTOR MYC NCK1 NCK2 NRAS NRG1 NRG2 NRG3 NRG4 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTK2 RAF1 RPS6KB1 RPS6KB2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 SRC STAT5A STAT5B TGFA +KEGG_ETHER_LIPID_METABOLISM Ether lipid metabolism AGPS CHPT1 ENPP2 ENPP6 JMJD7-PLA2G4B LPCAT1 LPCAT2 LPCAT4 PAFAH1B1 PAFAH1B2 PAFAH1B3 PAFAH2 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLA2G7 PLD1 PLD2 PPAP2A PPAP2B PPAP2C +KEGG_FATTY_ACID_METABOLISM Fatty acid metabolism ACAA1 ACAA2 ACADL ACADM ACADS ACADSB ACADVL ACAT1 ACAT2 ACOX1 ACOX3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 CPT1A CPT1B CPT1C CPT2 CYP4A11 CYP4A22 ECHS1 ECI1 ECI2 EHHADH GCDH HADH HADHA HADHB +KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY Fc epsilon RI signaling pathway AKT1 AKT2 AKT3 BTK CSF2 FCER1A FCER1G FYN GAB2 GRB2 HRAS IL13 IL3 IL4 IL5 INPP5D JMJD7-PLA2G4B KRAS LAT LCP2 LYN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MS4A2 NRAS PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE RAC1 RAC2 RAC3 RAF1 SOS1 SOS2 SYK TNF VAV1 VAV2 VAV3 +KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS Fc gamma R-mediated phagocytosis AKT1 AKT2 AKT3 AMPH ARF6 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L ASAP1 ASAP2 ASAP3 CDC42 CFL1 CFL2 CRK CRKL DNM1 DNM1L DNM2 DNM3 DOCK2 FCGR1A FCGR2A FCGR2B FCGR2C FCGR3A GAB2 GSN HCK INPP5D LAT LIMK1 LIMK2 LOC653888 LYN MAP2K1 MAPK1 MAPK3 MARCKS MARCKSL1 MYO10 NCF1 PAK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIKFYVE PIP4K2B PIP5K1A PIP5K1B PIP5K1C PLA2G4A PLA2G4B PLA2G4D PLA2G4E PLA2G4F PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PPAP2A PPAP2B PPAP2C PRKCA PRKCB PRKCD PRKCE PRKCG PTPRC RAC1 RAC2 RAF1 RPS6KB1 RPS6KB2 SCIN SPHK1 SPHK2 SYK VASP VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL +KEGG_FOCAL_ADHESION Focal adhesion ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 AKT1 AKT2 AKT3 ARHGAP35 ARHGAP5 BAD BCAR1 BCL2 BIRC2 BIRC3 BRAF CAPN2 CAV1 CAV2 CAV3 CCND1 CCND2 CCND3 CDC42 CHAD COL11A1 COL11A2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A4 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A6 COMP CRK CRKL CTNNB1 DIAPH1 DOCK1 EGF EGFR ELK1 ERBB2 FIGF FLNA FLNB FLNC FLT1 FLT4 FN1 FYN GRB2 GSK3B HGF HRAS IBSP IGF1 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUN KDR LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LOC100418883 LOC646821 MAP2K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MET MYL10 MYL12A MYL12B MYL2 MYL5 MYL7 MYL9 MYLK MYLK2 MYLK3 MYLPF PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PARVA PARVB PARVG PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDPK1 PGF PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIP5K1C PPP1CA PPP1CB PPP1CC PPP1R12A PRKCA PRKCB PRKCG PTEN PTK2 PXN RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RAPGEF1 RASGRF1 RELN RHOA ROCK1 ROCK2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 SPP1 SRC THBS1 THBS2 THBS3 THBS4 TLN1 TLN2 TNC TNN TNR TNXB VASP VAV1 VAV2 VAV3 VCL VEGFA VEGFB VEGFC VTN VWF XIAP ZYX +KEGG_FOLATE_BIOSYNTHESIS Folate biosynthesis ALPI ALPL ALPP ALPPL2 DHFR FPGS GCH1 GGH PTS QDPR SPR +KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM Fructose and mannose metabolism AKR1B1 AKR1B10 ALDOA ALDOB ALDOC FBP1 FBP2 FPGT FUK GMDS GMPPA GMPPB HK1 HK2 HK3 KHK MPI MTMR1 MTMR2 MTMR6 MTMR7 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PHPT1 PMM1 PMM2 SORD TPI1 TSTA3 +KEGG_GALACTOSE_METABOLISM Galactose metabolism AKR1B1 B4GALT1 B4GALT2 G6PC G6PC2 GAA GALE GALK1 GALK2 GALT GANC GCK GLA GLB1 HK1 HK2 HK3 LALBA LCT MGAM PFKL PFKM PFKP PGM1 PGM2 UGP2 +KEGG_GAP_JUNCTION Gap junction ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB1 CDK1 CSNK1D DRD1 DRD2 EGF EGFR GJA1 GJD2 GNA11 GNAI1 GNAI2 GNAI3 GNAQ GNAS GRB2 GRM1 GRM5 GUCY1A2 GUCY1A3 GUCY1B3 HRAS HTR2A HTR2B HTR2C ITPR1 ITPR2 ITPR3 KRAS LPAR1 MAP2K1 MAP2K2 MAP2K5 MAP3K2 MAPK1 MAPK3 MAPK7 NRAS PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKG1 PRKG2 PRKX RAF1 SOS1 SOS2 SRC TJP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 +KEGG_GLIOMA Glioma AKT1 AKT2 AKT3 ARAF BRAF CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CCND1 CDK4 CDK6 CDKN1A CDKN2A E2F1 E2F2 E2F3 EGF EGFR GRB2 HRAS IGF1 IGF1R KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MDM2 MTOR NRAS PDGFA PDGFB PDGFRA PDGFRB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTEN RAF1 RB1 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 TGFA TP53 +KEGG_GLUTATHIONE_METABOLISM Glutathione metabolism ANPEP G6PD GCLC GCLM GGCT GGT1 GGT5 GGT6 GGT7 GPX1 GPX2 GPX3 GPX4 GPX5 GPX6 GPX7 GSR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTZ1 IDH1 IDH2 LAP3 MGST1 MGST2 MGST3 ODC1 OPLAH PGD RRM1 RRM2 RRM2B SMS SRM TXNDC12 +KEGG_GLYCEROLIPID_METABOLISM Glycerolipid metabolism AGK AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT6 AGPAT9 AKR1A1 AKR1B1 ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 AWAT2 CEL DAK DGAT1 DGAT2 DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKQ DGKZ GK GK2 GLA GLYCTK GPAM GPAT2 LCLAT1 LIPC LIPF LIPG LPL MBOAT1 MBOAT2 MGLL PNLIP PNLIPRP1 PNLIPRP2 PNPLA3 PPAP2A PPAP2B PPAP2C +KEGG_GLYCEROPHOSPHOLIPID_METABOLISM Glycerophospholipid metabolism ACHE AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT6 AGPAT9 C17orf48 CDIPT CDS1 CDS2 CHAT CHKA CHKB CHPT1 CRLS1 DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKQ DGKZ ETNK1 ETNK2 GNPAT GPAM GPAT2 GPD1 GPD1L GPD2 JMJD7-PLA2G4B LCAT LCLAT1 LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LYPLA1 LYPLA2 MBOAT1 MBOAT2 MBOAT7 PCYT1A PCYT1B PCYT2 PEMT PGS1 PHOSPHO1 PISD PLA2G10 PLA2G12A PLA2G12B PLA2G15 PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLD1 PLD2 PPAP2A PPAP2B PPAP2C PTDSS1 PTDSS2 TAZ +KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM Glycine, serine and threonine metabolism AGXT AGXT2 ALAS1 ALAS2 AMT AOC2 AOC3 BHMT CBS CHDH CTH DAO DLD DMGDH GAMT GATM GCAT GLDC GLYCTK GNMT MAOA MAOB PHGDH PIPOX PSAT1 PSPH SARDH SDS SHMT1 SHMT2 SRR +KEGG_GLYCOLYSIS_GLUCONEOGENESIS Glycolysis / Gluconeogenesis ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AKR1A1 ALDH1A3 ALDH1B1 ALDH2 ALDH3A1 ALDH3A2 ALDH3B1 ALDH3B2 ALDH7A1 ALDH9A1 ALDOA ALDOB ALDOC BPGM DLAT DLD ENO1 ENO2 ENO3 FBP1 FBP2 G6PC G6PC2 GALM GAPDH GCK GPI HK1 HK2 HK3 LDHA LDHAL6A LDHAL6B LDHB LDHC PCK1 PCK2 PDHA1 PDHA2 PDHB PFKL PFKM PFKP PGAM1 PGAM2 PGAM4 PGK1 PGK2 PGM1 PGM2 PKLR PKM2 TPI1 +KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE Glycosaminoglycan biosynthesis - chondroitin sulfate B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 CHPF CHPF2 CHST11 CHST12 CHST13 CHST14 CHST15 CHST3 CHST7 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 DSE UST XYLT1 XYLT2 +KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE Glycosaminoglycan biosynthesis - heparan sulfate B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 EXT1 EXT2 EXTL1 EXTL2 EXTL3 GLCE HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST5 HS6ST1 HS6ST2 HS6ST3 NDST1 NDST2 NDST3 NDST4 XYLT1 XYLT2 +KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE Glycosaminoglycan biosynthesis - keratan sulfate B3GNT1 B3GNT2 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 CHST1 CHST2 CHST4 CHST6 FUT8 ST3GAL1 ST3GAL2 ST3GAL3 +KEGG_GLYCOSAMINOGLYCAN_DEGRADATION Glycosaminoglycan degradation ARSB GALNS GLB1 GNS GUSB HEXA HEXB HGSNAT HPSE HPSE2 HS3ST3A1 HS3ST3B1 HYAL1 HYAL2 HYAL3 HYAL4 IDS IDUA NAGLU SGSH SPAM1 +KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES Glycosphingolipid biosynthesis - ganglio series B3GALT4 B4GALNT1 GLB1 HEXA HEXB SLC33A1 ST3GAL1 ST3GAL2 ST3GAL5 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA5 +KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES Glycosphingolipid biosynthesis - globo series A4GALT B3GALNT1 B3GALT5 FUT1 FUT2 FUT9 GBGT1 GLA HEXA HEXB NAGA ST3GAL1 ST3GAL2 ST8SIA1 +KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES Glycosphingolipid biosynthesis - lacto and neolacto series ABO B3GALT1 B3GALT2 B3GALT5 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT5 B4GALT1 B4GALT2 B4GALT3 B4GALT4 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT9 GCNT2 ST3GAL3 ST3GAL4 ST3GAL6 ST8SIA1 +KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS Glycosylphosphatidylinositol(GPI)-anchor biosynthesis DPM2 GPAA1 GPLD1 PGAP1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PIGY PIGZ +KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Glyoxylate and dicarboxylate metabolism ACO1 ACO2 AFMID CS GLYCTK GRHPR HAO1 HAO2 HYI MDH1 MDH2 MTHFD1 MTHFD1L MTHFD2 MTHFD2L PGP +KEGG_GNRH_SIGNALING_PATHWAY GnRH signaling pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ATF4 CACNA1C CACNA1D CACNA1F CACNA1S CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CDC42 CGA EGFR ELK1 FSHB GNA11 GNAQ GNAS GNRH1 GNRH2 GNRHR GRB2 HBEGF HRAS ITPR1 ITPR2 ITPR3 JMJD7-PLA2G4B JUN KRAS LHB MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MMP14 MMP2 NRAS PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLCB1 PLCB2 PLCB3 PLCB4 PLD1 PLD2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKX PTK2B RAF1 SOS1 SOS2 SRC +KEGG_GRAFT_VERSUS_HOST_DISEASE Graft-versus-host disease CD28 CD80 CD86 FAS FASLG GZMB HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G IFNG IL1A IL1B IL2 IL6 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL5A KIR3DL1 KIR3DL2 KLRC1 KLRD1 LOC652614 PRF1 TNF +KEGG_HEDGEHOG_SIGNALING_PATHWAY Hedgehog signaling pathway BMP2 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B BTRC CSNK1A1 CSNK1A1L CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 DHH FBXW11 GAS1 GLI1 GLI2 GLI3 GSK3B HHIP IHH LRP2 PRKACA PRKACB PRKACG PRKX PTCH1 PTCH2 RAB23 SHH SMO STK36 SUFU WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B ZIC2 +KEGG_HEMATOPOIETIC_CELL_LINEAGE Hematopoietic cell lineage ANPEP CD14 CD19 CD1A CD1B CD1C CD1D CD1E CD2 CD22 CD33 CD34 CD36 CD37 CD38 CD3D CD3E CD3G CD4 CD44 CD5 CD55 CD59 CD7 CD8A CD8B CD9 CR1 CR2 CSF1 CSF1R CSF2 CSF2RA CSF3 CSF3R DNTT EPO EPOR FCER2 FCGR1A FLT3 FLT3LG GP1BA GP1BB GP5 GP9 GYPA HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL11 IL11RA IL1A IL1B IL1R1 IL1R2 IL2RA IL3 IL3RA IL4 IL4R IL5 IL5RA IL6 IL6R IL7 IL7R IL9R ITGA1 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGAM ITGB3 KIT KITLG LOC652799 MME MS4A1 TFRC THPO TNF TPO +KEGG_HISTIDINE_METABOLISM Histidine metabolism ABP1 ACY3 ALDH1A3 ALDH1B1 ALDH2 ALDH3A1 ALDH3A2 ALDH3B1 ALDH3B2 ALDH7A1 ALDH9A1 AMDHD1 ASPA CNDP1 DDC FTCD HAL HDC HEMK1 HNMT LCMT1 LCMT2 MAOA MAOB METTL2B METTL6 TRMT11 UROC1 WBSCR22 +KEGG_HOMOLOGOUS_RECOMBINATION Homologous recombination BLM BRCA2 EME1 MRE11A MUS81 NBN POLD1 POLD2 POLD3 POLD4 RAD50 RAD51 RAD51B RAD51C RAD51D RAD52 RAD54B RAD54L RPA1 RPA2 RPA3 RPA4 SHFM1 SSBP1 TOP3A TOP3B XRCC2 XRCC3 +KEGG_HUNTINGTONS_DISEASE Huntington's disease AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APAF1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G1P5 ATP5G2 ATP5G3 ATP5H ATP5J ATP5O ATP6 ATP8 BAX BBC3 BDNF CASP3 CASP8 CASP9 CLTA CLTB CLTC CLTCL1 COX1 COX2 COX3 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX6CP3 COX7A1 COX7A2 COX7A2L COX7B COX7B2 COX7C COX8A COX8C CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CREBBP CYC1 CYCS CYTB DCTN1 DCTN2 DCTN4 DLG4 DNAH1 DNAH2 DNAH3 DNAI1 DNAI2 DNAL1 DNAL4 DNALI1 EP300 GNAQ GPX1 GRIN1 GRIN2B GRM5 HAP1 HDAC1 HDAC2 HIP1 HTT IFT57 ITPR1 LOC100133737 LOC642502 LOC644310 LOC727947 LOC729317 NDUFA1 NDUFA10 NDUFA2 NDUFA3 NDUFA4 NDUFA4L2 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NRF1 PLCB1 PLCB2 PLCB3 PLCB4 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2J3 POLR2K POLR2L PPARG PPARGC1A PPID RCOR1 REST SDHA SDHB SDHC SDHD SIN3A SLC25A31 SLC25A4 SLC25A5 SLC25A6 SOD1 SOD2 SP1 TAF4 TAF4B TBP TBPL1 TBPL2 TFAM TGM2 TP53 UCP1 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ VDAC1 VDAC2 VDAC3 +KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM Hypertrophic cardiomyopathy (HCM) ACE ACTB ACTC1 ACTG1 ATP2A2 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 DAG1 DES DMD EMD IGF1 IL6 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 LAMA2 LMNA LOC100418883 LOC646821 MYBPC3 MYH6 MYH7 MYL2 MYL3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RYR2 SGCA SGCB SGCD SGCG SLC8A1 TGFB1 TGFB2 TGFB3 TNF TNNC1 TNNI3 TNNT2 TPM1 TPM2 TPM3 TPM4 TTN +KEGG_INOSITOL_PHOSPHATE_METABOLISM Inositol phosphate metabolism ALDH6A1 CDIPT IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5E INPP5J INPP5K INPPL1 IPMK IPPK ISYNA1 ITPK1 ITPKA ITPKB MINPP1 MIOX OCRL PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIKFYVE PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PTEN SYNJ1 SYNJ2 TPI1 +KEGG_INSULIN_SIGNALING_PATHWAY Insulin signaling pathway ACACA ACACB AKT1 AKT2 AKT3 ARAF BAD BRAF CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CBL CBLB CBLC CRK CRKL EIF4E EIF4E1B EIF4E2 EIF4EBP1 ELK1 EXOC7 FASN FBP1 FBP2 FLOT1 FLOT2 FOXO1 G6PC G6PC2 GCK GRB2 GSK3B GYS1 GYS2 HK1 HK2 HK3 HRAS IKBKB INPP5D INPP5K INS INSR IRS1 IRS2 IRS4 KRAS LIPE MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MKNK1 MKNK2 MTOR NRAS PCK1 PCK2 PDE3A PDE3B PDPK1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PKLR PPARGC1A PPP1CA PPP1CB PPP1CC PPP1R3A PPP1R3B PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCI PRKCZ PRKX PTPN1 PTPRF PYGB PYGL PYGM RAF1 RAPGEF1 RHEB RHOQ RPS6 RPS6KB1 RPS6KB2 RPTOR SH2B2 SHC1 SHC2 SHC3 SHC4 SLC2A4 SOCS1 SOCS2 SOCS3 SOCS4 SORBS1 SOS1 SOS2 SREBF1 TRIP10 TSC1 TSC2 +KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION Intestinal immune network for IgA production AICDA CCL25 CCL27 CCL28 CCR10 CCR9 CD28 CD40 CD40LG CD80 CD86 CXCL12 CXCR4 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICOS ICOSLG IL10 IL15 IL15RA IL2 IL4 IL5 IL6 ITGA4 ITGB7 LTBR MADCAM1 MAP3K14 PIGR TGFB1 TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13 TNFSF13B +KEGG_JAK_STAT_SIGNALING_PATHWAY Jak-STAT signaling pathway AKT1 AKT2 AKT3 BCL2L1 CBL CBLB CBLC CCND1 CCND2 CCND3 CISH CLCF1 CNTF CNTFR CREBBP CRLF2 CSF2 CSF2RA CSF2RB CSF3 CSF3R CSH1 CTF1 EP300 EPO EPOR GH1 GH2 GHR GRB2 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNE IFNG IFNGR1 IFNGR2 IFNK IFNW1 IL10 IL10RA IL10RB IL11 IL11RA IL12A IL12B IL12RB1 IL12RB2 IL13 IL13RA1 IL13RA2 IL15 IL15RA IL19 IL2 IL20 IL20RA IL20RB IL21 IL21R IL22 IL22RA1 IL22RA2 IL23A IL23R IL24 IL26 IL28A IL28B IL28RA IL29 IL2RA IL2RB IL2RG IL3 IL3RA IL4 IL4R IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R IL9 IL9R IRF9 JAK1 JAK2 JAK3 LEP LEPR LIF LIFR MPL MYC OSM OSMR PIAS1 PIAS2 PIAS3 PIAS4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIM1 PRL PRLR PTPN11 PTPN6 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS7 SOS1 SOS2 SPRED1 SPRED2 SPRY1 SPRY2 SPRY3 SPRY4 STAM STAM2 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TPO TSLP TYK2 +KEGG_LEISHMANIA_INFECTION Leishmania infection C3 CR1 CYBA ELK1 FCGR1A FCGR2A FCGR2C FCGR3A FCGR3B FOS HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IFNG IFNGR1 IFNGR2 IL10 IL12A IL12B IL1A IL1B IL4 IRAK1 IRAK4 ITGA4 ITGAM ITGB1 ITGB2 JAK1 JAK2 JUN MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MARCKSL1 MYD88 NCF1 NCF2 NCF4 NFKB1 NFKBIA NFKBIB NOS2 PRKCB PTGS2 PTPN6 RELA STAT1 TAB1 TAB2 TGFB1 TGFB2 TGFB3 TLR2 TLR4 TNF TRAF6 +KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Leukocyte transendothelial migration ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 ARHGAP35 ARHGAP5 BCAR1 CD99 CDC42 CDH5 CLDN1 CLDN10 CLDN11 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 CXCL12 CXCR4 CYBA CYBB ESAM EZR F11R GNAI1 GNAI2 GNAI3 ICAM1 ITGA4 ITGAL ITGAM ITGB1 ITGB2 ITK JAM2 JAM3 LOC100418883 LOC646821 MAPK11 MAPK12 MAPK13 MAPK14 MLLT4 MMP2 MMP9 MSN MYL10 MYL12A MYL12B MYL2 MYL5 MYL7 MYL9 MYLPF NCF1 NCF2 NCF4 NOX1 NOX3 OCLN PECAM1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTK2 PTK2B PTPN11 PXN RAC1 RAC2 RAP1A RAP1B RAPGEF3 RAPGEF4 RASSF5 RHOA RHOH ROCK1 ROCK2 SIPA1 THY1 TXK VASP VAV1 VAV2 VAV3 VCAM1 VCL +KEGG_LIMONENE_AND_PINENE_DEGRADATION Limonene and pinene degradation ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 ECHS1 EHHADH HADHA NAT6 YOD1 +KEGG_LINOLEIC_ACID_METABOLISM Linoleic acid metabolism AKR1B10 ALOX15 CYP1A2 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2E1 CYP2J2 CYP3A4 CYP3A43 CYP3A5 CYP3A7 JMJD7-PLA2G4B PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 +KEGG_LONG_TERM_DEPRESSION Long-term depression ARAF BRAF CACNA1A CRH CRHR1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS GNAZ GRIA1 GRIA2 GRIA3 GRID2 GRM1 GRM5 GUCY1A2 GUCY1A3 GUCY1B3 HRAS IGF1 IGF1R ITPR1 ITPR2 ITPR3 JMJD7-PLA2G4B KRAS LYN MAP2K1 MAP2K2 MAPK1 MAPK3 NOS1 NRAS PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLCB1 PLCB2 PLCB3 PLCB4 PPP1R17 PPP2CA PPP2CB PPP2R1A PPP2R1B PRKCA PRKCB PRKCG PRKG1 PRKG2 RAF1 RYR1 +KEGG_LONG_TERM_POTENTIATION Long-term potentiation ADCY1 ADCY8 ARAF ATF4 BRAF CACNA1C CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CHP CHP2 CREBBP EP300 GNAQ GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 GRM5 HRAS ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PLCB1 PLCB2 PLCB3 PLCB4 PPP1CA PPP1CB PPP1CC PPP1R12A PPP1R1A PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX RAF1 RAP1A RAP1B RAPGEF3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 +KEGG_LYSINE_DEGRADATION Lysine degradation AADAT AASDH AASDHPPT AASS ACAT1 ACAT2 ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 ASH1L BBOX1 DLST DOT1L ECHS1 EHHADH EHMT1 EHMT2 GCDH HADH HADHA NSD1 OGDH OGDHL PIPOX PLOD1 PLOD2 PLOD3 SETD1A SETD1B SETD2 SETD7 SETD8 SETDB1 SETDB2 SETMAR SUV39H1 SUV39H2 SUV420H1 SUV420H2 TMLHE WHSC1 WHSC1L1 +KEGG_LYSOSOME Lysosome ABCA2 ABCB9 ACP2 ACP5 AGA AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2 AP4B1 AP4E1 AP4M1 AP4S1 ARSA ARSB ARSG ASAH1 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V1H CD164 CD63 CD68 CLN3 CLN5 CLTA CLTB CLTC CLTCL1 CTNS CTSA CTSB CTSC CTSD CTSE CTSF CTSG CTSH CTSK CTSL1 CTSL2 CTSO CTSS CTSW CTSZ DNASE2 DNASE2B ENTPD4 FUCA1 GAA GALC GALNS GBA GGA1 GGA2 GGA3 GLA GLB1 GM2A GNPTAB GNPTG GNS GUSB HEXA HEXB HGSNAT HYAL1 IDS IDUA IGF2R LAMP1 LAMP2 LAMP3 LAPTM4A LAPTM4B LAPTM5 LGMN LIPA M6PR MAN2B1 MANBA MCOLN1 MFSD8 NAGA NAGLU NAGPA NAPSA NEU1 NPC1 NPC2 PLA2G15 PPT1 PPT2 PSAP PSAPL1 SCARB2 SGSH SLC11A1 SLC11A2 SLC17A5 SMPD1 SORT1 SUMF1 TCIRG1 TPP1 +KEGG_MAPK_SIGNALING_PATHWAY MAPK signaling pathway AKT1 AKT2 AKT3 ARRB1 ARRB2 ATF2 ATF4 BDNF BRAF CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CASP3 CD14 CDC25B CDC42 CHP CHP2 CHUK CRK CRKL DAXX DDIT3 DUSP1 DUSP10 DUSP14 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 ECSIT EGF EGFR ELK1 ELK4 FAS FASLG FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLNA FLNB FLNC FOS GADD45A GADD45B GADD45G GNA12 GNG12 GRB2 HRAS HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPB1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 JMJD7-PLA2G4B JUN JUND KRAS LAMTOR3 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MAX MECOM MEF2C MKNK1 MKNK2 MOS MRAS MYC NF1 NFATC2 NFATC4 NFKB1 NFKB2 NGF NLK NR4A1 NRAS NTF3 NTF4 NTRK1 NTRK2 PAK1 PAK2 PDGFA PDGFB PDGFRA PDGFRB PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PPM1A PPM1B PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PPP5C PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX PTPN5 PTPN7 PTPRR RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RAPGEF2 RASA1 RASA2 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RELA RELB RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS RRAS2 SOS1 SOS2 SRF STK3 STK4 STMN1 TAB1 TAB2 TAOK1 TAOK2 TAOK3 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TNF TNFRSF1A TP53 TRAF2 TRAF6 ZAK +KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG Maturity onset diabetes of the young BHLHA15 FOXA2 FOXA3 GCK HES1 HHEX HNF1A HNF1B HNF4A HNF4G IAPP INS MAFA MNX1 NEUROD1 NEUROG3 NKX2-2 NKX6-1 NR5A2 ONECUT1 PAX4 PAX6 PDX1 PKLR SLC2A2 +KEGG_MELANOGENESIS Melanogenesis ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ASIP CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREBBP CTNNB1 DCT DVL1 DVL2 DVL3 EDN1 EDNRB EP300 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS GSK3B HRAS KIT KITLG KRAS LEF1 LOC652799 MAP2K1 MAP2K2 MAPK1 MAPK3 MC1R MITF NRAS PLCB1 PLCB2 PLCB3 PLCB4 POMC PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX RAF1 TCF7 TCF7L1 TCF7L2 TYR TYRP1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +KEGG_MELANOMA Melanoma AKT1 AKT2 AKT3 ARAF BAD BRAF CCND1 CDH1 CDK4 CDK6 CDKN1A CDKN2A E2F1 E2F2 E2F3 EGF EGFR FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 HGF HRAS IGF1 IGF1R KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MDM2 MET MITF NRAS PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTEN RAF1 RB1 TP53 +KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Metabolism of xenobiotics by cytochrome P450 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AKR1C1 AKR1C2 AKR1C3 AKR1C4 ALDH1A3 ALDH3A1 ALDH3B1 ALDH3B2 CYP1A1 CYP1A2 CYP1B1 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2E1 CYP2F1 CYP2S1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 DHDH EPHX1 GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTZ1 MGST1 MGST2 MGST3 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +KEGG_MISMATCH_REPAIR Mismatch repair EXO1 LIG1 MLH1 MLH3 MSH2 MSH3 MSH6 PCNA PMS2 POLD1 POLD2 POLD3 POLD4 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 SSBP1 +KEGG_MTOR_SIGNALING_PATHWAY mTOR signaling pathway AKT1 AKT2 AKT3 BRAF CAB39 CAB39L DDIT4 EIF4B EIF4E EIF4E1B EIF4E2 EIF4EBP1 FIGF HIF1A IGF1 INS MAPK1 MAPK3 MLST8 MTOR PDPK1 PGF PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PRKAA1 PRKAA2 RHEB RICTOR RPS6 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KB1 RPS6KB2 RPTOR STK11 STRADA TSC1 TSC2 ULK1 ULK2 ULK3 VEGFA VEGFB VEGFC +KEGG_N_GLYCAN_BIOSYNTHESIS N-Glycan biosynthesis ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 DAD1 DDOST DOLPP1 DPAGT1 DPM1 DPM2 DPM3 FUT8 GANAB MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT5 MGAT5B MOGS RFT1 RPN1 RPN2 ST6GAL1 STT3A STT3B TUSC3 +KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Natural killer cell mediated cytotoxicity ARAF BID BRAF CASP3 CD244 CD247 CD48 CHP CHP2 CSF2 FAS FASLG FCER1G FCGR3A FCGR3B FYN GRB2 GZMB HCST HLA-A HLA-B HLA-C HLA-E HLA-G HRAS ICAM1 ICAM2 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 ITGAL ITGB2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DL5A KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DL2 KLRC1 KLRC2 KLRC3 KLRD1 KLRK1 KRAS LAT LCK LCP2 MAP2K1 MAP2K2 MAPK1 MAPK3 MICA MICB NCR1 NCR2 NCR3 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NRAS PAK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRF1 PRKCA PRKCB PRKCG PTK2B PTPN11 PTPN6 RAC1 RAC2 RAC3 RAET1E RAET1G RAET1L RAF1 SH2D1A SH2D1B SH3BP2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 SYK TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFSF10 TYROBP ULBP1 ULBP2 ULBP3 VAV1 VAV2 VAV3 ZAP70 +KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Neuroactive ligand-receptor interaction ADCYAP1R1 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 AGTR2 APLNR AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3AR1 C5AR1 CALCR CALCRL CCKAR CCKBR CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CHRNA1 CHRNA10 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB1 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG CNR1 CNR2 CRHR1 CRHR2 CSH1 CTSG CYSLTR1 CYSLTR2 DRD1 DRD2 DRD3 DRD4 DRD5 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FPR1 FPR2 FPR3 FSHB FSHR GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GABRR1 GABRR2 GALR1 GALR2 GALR3 GCGR GH1 GH2 GHR GHRHR GHSR GIPR GLP1R GLP2R GLRA1 GLRA2 GLRA3 GLRB GNRHR GPR156 GPR35 GPR50 GPR83 GRIA1 GRIA2 GRIA3 GRIA4 GRID1 GRID2 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRPR GZMA HCRTR1 HCRTR2 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 KISS1R LEP LEPR LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MAS1 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLNR MTNR1A MTNR1B NMBR NMUR1 NMUR2 NPBWR1 NPBWR2 NPFFR1 NPFFR2 NPY1R NPY2R NPY5R NR3C1 NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 OXTR P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 P2RY1 P2RY10 P2RY11 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P2RY8 PARD3 PLG PPYR1 PRL PRLHR PRLR PRSS1 PRSS2 PRSS3 PTAFR PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH1R PTH2R RXFP1 RXFP2 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SCTR SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 TACR1 TACR2 TACR3 TBXA2R THRA THRB TRHR TRPV1 TSHB TSHR TSPO UTS2R VIPR1 VIPR2 +KEGG_NEUROTROPHIN_SIGNALING_PATHWAY Neurotrophin signaling pathway ABL1 AKT1 AKT2 AKT3 ARHGDIA ARHGDIB ATF4 BAD BAX BCL2 BDNF BRAF CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CDC42 CRK CRKL CSK FASLG FOXO3 FRS2 GAB1 GRB2 GSK3B HRAS IKBKB IRAK1 IRAK2 IRAK3 IRAK4 IRS1 IRS2 IRS4 JUN KIDINS220 KRAS MAGED1 MAP2K1 MAP2K2 MAP2K5 MAP2K7 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NFKBIA NFKBIB NFKBIE NGF NGFR NGFRAP1 NRAS NTF3 NTF4 NTRK1 NTRK2 NTRK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PRDM4 PRKCD PSEN1 PTPN11 RAC1 RAF1 RAP1A RAP1B RAPGEF1 RELA RHOA RIPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SH2B1 SH2B2 SH2B3 SHC1 SHC2 SHC3 SHC4 SORT1 SOS1 SOS2 TP53 TP73 TRAF6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZNF274 +KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Nicotinate and nicotinamide metabolism AOX1 BST1 C9orf95 CD38 ENPP1 ENPP3 NADK NADSYN1 NAMPT NMNAT1 NMNAT2 NMNAT3 NNMT NNT NT5C NT5C1A NT5C1B NT5C2 NT5C3 NT5E NT5M NUDT12 PNP QPRT +KEGG_NITROGEN_METABOLISM Nitrogen metabolism AMT ASNS CA1 CA12 CA13 CA14 CA2 CA3 CA4 CA5A CA5B CA6 CA7 CA8 CA9 CPS1 CTH GLS GLS2 GLUD1 GLUD2 GLUL HAL +KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY NOD-like receptor signaling pathway BIRC2 BIRC3 CARD18 CARD6 CARD8 CARD9 CASP1 CASP5 CASP8 CCL11 CCL13 CCL2 CCL5 CCL7 CCL8 CHUK CXCL1 CXCL2 ERBB2IP HSP90AA1 HSP90AB1 HSP90B1 IKBKB IKBKG IL18 IL1B IL6 IL8 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MEFV NAIP NFKB1 NFKBIA NFKBIB NLRC4 NLRP1 NLRP3 NOD1 NOD2 PSTPIP1 PYCARD PYDC1 RELA RIPK2 SUGT1 TAB1 TAB2 TAB3 TNF TNFAIP3 TRAF6 TRIP6 XIAP +KEGG_NON_HOMOLOGOUS_END_JOINING Non-homologous end-joining DCLRE1C DNTT FEN1 LIG4 LOC731751 MRE11A NHEJ1 POLL POLM PRKDC RAD50 XRCC4 XRCC5 XRCC6 +KEGG_NON_SMALL_CELL_LUNG_CANCER Non-small cell lung cancer AKT1 AKT2 AKT3 ARAF BAD BRAF CASP9 CCND1 CDK4 CDK6 CDKN2A E2F1 E2F2 E2F3 EGF EGFR ERBB2 FHIT FOXO3 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCG RAF1 RARB RASSF1 RASSF5 RB1 RXRA RXRB RXRG SOS1 SOS2 STK4 TGFA TP53 +KEGG_NOTCH_SIGNALING_PATHWAY Notch signaling pathway ADAM17 APH1A CIR1 CREBBP CTBP1 CTBP2 DLL1 DLL3 DLL4 DTX1 DTX2 DTX3 DTX3L DTX4 DVL1 DVL2 DVL3 EP300 HDAC1 HDAC2 HES1 HES5 JAG1 JAG2 KAT2A KAT2B LFNG MAML1 MAML2 MAML3 MFNG NCOR2 NCSTN NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUMB NUMBL PSEN1 PSEN2 PSENEN PTCRA RBPJ RBPJL RFNG SNW1 +KEGG_NUCLEOTIDE_EXCISION_REPAIR Nucleotide excision repair CCNH CDK7 CETN2 CUL4A CUL4B DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 LIG1 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 RAD23A RAD23B RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 XPA XPC +KEGG_O_GLYCAN_BIOSYNTHESIS O-Glycan biosynthesis B3GNT6 B4GALT5 C1GALT1 C1GALT1C1 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL1 GALNTL2 GALNTL4 GALNTL5 GALNTL6 GCNT1 GCNT3 GCNT4 ST3GAL1 ST3GAL2 ST6GALNAC1 WBSCR17 +KEGG_OLFACTORY_TRANSDUCTION Olfactory transduction ADCY3 ADRBK2 ARRB2 CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CLCA1 CLCA2 CLCA4 CNGA3 CNGA4 CNGB1 GNAL GUCA1A GUCA1B GUCA1C GUCY2D OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AD1 OR10AG1 OR10C1 OR10G2 OR10G3 OR10G4 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J5 OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10X1 OR10Z1 OR11A1 OR11G2 OR11H1 OR11H4 OR11H6 OR11L1 OR12D2 OR12D3 OR13A1 OR13C2 OR13C3 OR13C4 OR13C5 OR13C8 OR13C9 OR13D1 OR13F1 OR13G1 OR13H1 OR13J1 OR14A16 OR14C36 OR14I1 OR14J1 OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1F1 OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A42 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AG2 OR2AK2 OR2AT4 OR2B11 OR2B2 OR2B3 OR2B6 OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2H2 OR2J2 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T4 OR2T5 OR2T6 OR2T8 OR2V2 OR2W1 OR2W3 OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR4A15 OR4A16 OR4A47 OR4A5 OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C45 OR4C46 OR4C6 OR4D1 OR4D10 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E2 OR4F15 OR4F16 OR4F17 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N4 OR4N5 OR4P4 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F1 OR51F2 OR51G1 OR51G2 OR51I1 OR51I2 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A5 OR52B2 OR52B4 OR52B6 OR52D1 OR52E2 OR52E4 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52R1 OR52W1 OR56A1 OR56A3 OR56A4 OR56A5 OR56B1 OR56B4 OR5A1 OR5A2 OR5AC2 OR5AK2 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B21 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5L1 OR5L2 OR5M1 OR5M10 OR5M11 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6C6 OR6C65 OR6C68 OR6C70 OR6C74 OR6C75 OR6C76 OR6F1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7E24 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8G1 OR8G2 OR8G5 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR9A2 OR9A4 OR9G1 OR9G4 OR9I1 OR9K2 OR9Q1 OR9Q2 PDC PDE1C PRKACA PRKACB PRKACG PRKG1 PRKG2 PRKX +KEGG_ONE_CARBON_POOL_BY_FOLATE One carbon pool by folate ALDH1L1 AMT ATIC DHFR FTCD GART MTFMT MTHFD1 MTHFD1L MTHFD2 MTHFD2L MTHFR MTHFS MTR SHMT1 SHMT2 TYMS +KEGG_OOCYTE_MEIOSIS Oocyte meiosis ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AR AURKA BTRC BUB1 CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CCNB1 CCNB2 CCNE1 CCNE2 CDC16 CDC20 CDC23 CDC25C CDC26 CDC27 CDK1 CDK2 CHP CHP2 CPEB1 CUL1 ESPL1 FBXO43 FBXO5 FBXW11 IGF1 IGF1R INS ITPR1 ITPR2 ITPR3 LOC650621 LOC728622 MAD2L1 MAD2L2 MAP2K1 MAPK1 MAPK12 MAPK3 MOS PGR PKMYT1 PLCZ1 PLK1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKX PTTG1 PTTG2 RBX1 REC8 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 SGOL1 SKP1 SLK SMC1A SMC1B SMC3 SPDYA SPDYC STAG3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +KEGG_OTHER_GLYCAN_DEGRADATION Other glycan degradation AGA ENGASE FUCA1 FUCA2 GBA GLB1 HEXA HEXB MAN2B1 MAN2B2 MAN2C1 MANBA NEU1 NEU2 NEU3 NEU4 +KEGG_OXIDATIVE_PHOSPHORYLATION Oxidative phosphorylation ATP12A ATP4A ATP4B ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G1P5 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATP8 COX1 COX10 COX11 COX15 COX17 COX2 COX3 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX6CP3 COX7A1 COX7A2 COX7A2L COX7B COX7B2 COX7C COX8A COX8C CYC1 CYTB LHPP LOC100133737 LOC642502 LOC644310 LOC727947 ND1 ND2 ND3 ND4 ND4L ND5 ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA2 NDUFA3 NDUFA4 NDUFA4L2 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 PPA1 PPA2 SDHA SDHB SDHC SDHD TCIRG1 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +KEGG_P53_SIGNALING_PATHWAY p53 signaling pathway APAF1 ATM ATR BAI1 BAX BBC3 BID CASP3 CASP8 CASP9 CCNB1 CCNB2 CCNB3 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNG1 CCNG2 CD82 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CHEK1 CHEK2 CYCS DDB2 EI24 FAS GADD45A GADD45B GADD45G GTSE1 IGF1 IGFBP3 LOC651610 MDM2 MDM4 PERP PIDD PMAIP1 PPM1D PTEN RCHY1 RFWD2 RPRM RRM2 RRM2B SERPINB5 SERPINE1 SESN1 SESN2 SESN3 SFN SHISA5 SIAH1 STEAP3 THBS1 TNFRSF10B TP53 TP53AIP1 TP53I3 TP73 TSC2 ZMAT3 +KEGG_PANCREATIC_CANCER Pancreatic cancer AKT1 AKT2 AKT3 ARAF ARHGEF6 BAD BCL2L1 BRAF BRCA2 CASP9 CCND1 CDC42 CDK4 CDK6 CDKN2A CHUK E2F1 E2F2 E2F3 EGF EGFR ERBB2 FIGF IKBKB IKBKG JAK1 KRAS MAP2K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NFKB1 PGF PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLD1 RAC1 RAC2 RAC3 RAD51 RAF1 RALA RALB RALBP1 RALGDS RB1 RELA SMAD2 SMAD3 SMAD4 STAT1 STAT3 TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TP53 VEGFA VEGFB VEGFC +KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS Pantothenate and CoA biosynthesis BCAT1 BCAT2 COASY DPYD DPYS ENPP1 ENPP3 PANK1 PANK2 PANK3 PANK4 PPCDC PPCS UPB1 VNN1 VNN2 +KEGG_PARKINSONS_DISEASE Parkinson's disease APAF1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G1P5 ATP5G2 ATP5G3 ATP5H ATP5J ATP5O ATP6 ATP8 CASP3 CASP9 COX1 COX2 COX3 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX6CP3 COX7A1 COX7A2 COX7A2L COX7B COX7B2 COX7C COX8A COX8C CYC1 CYCS CYTB GPR37 HTRA2 LOC100133737 LOC642502 LOC644310 LOC727947 LOC729317 LRRK2 ND1 ND2 ND3 ND4 ND4L ND5 ND6 NDUFA1 NDUFA10 NDUFA2 NDUFA3 NDUFA4 NDUFA4L2 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 PARK2 PARK7 PINK1 PPID SDHA SDHB SDHC SDHD SEPT5 SLC18A1 SLC18A2 SLC25A31 SLC25A4 SLC25A5 SLC25A6 SLC6A3 SNCA SNCAIP TH UBA1 UBA7 UBB UBE2G1 UBE2G2 UBE2J1 UBE2J2 UBE2L3 UBE2L6 UCHL1 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ VDAC1 VDAC2 VDAC3 +KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION Pathogenic Escherichia coli infection ABL1 ACTB ACTG1 ARHGEF2 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L CD14 CDC42 CDH1 CLDN1 CTNNB1 CTTN EZR FYN HCLS1 ITGB1 KRT18 LOC100418883 LOC646821 LOC653888 LY96 NCK1 NCK2 NCL OCLN PRKCA RHOA ROCK1 ROCK2 TLR4 TLR5 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 WAS WASL YWHAQ YWHAZ +KEGG_PATHWAYS_IN_CANCER Pathways in cancer ABL1 AKT1 AKT2 AKT3 APC APC2 APPL1 AR ARAF ARNT ARNT2 AXIN1 AXIN2 BAD BAX BCL2 BCL2L1 BCR BID BIRC2 BIRC3 BIRC5 BMP2 BMP4 BRAF BRCA2 CASP3 CASP8 CASP9 CBL CBLB CBLC CCDC6 CCNA1 CCND1 CCNE1 CCNE2 CDC42 CDH1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CEBPA CHUK CKS1B COL4A1 COL4A2 COL4A4 COL4A6 CREBBP CRK CRKL CSF1R CSF2RA CSF3R CTBP1 CTBP2 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CUL2 CYCS DAPK1 DAPK2 DAPK3 DCC DVL1 DVL2 DVL3 E2F1 E2F2 E2F3 EGF EGFR EGLN1 EGLN2 EGLN3 EP300 EPAS1 ERBB2 ETS1 FADD FAS FASLG FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FH FIGF FLT3 FLT3LG FN1 FOS FOXO1 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GLI1 GLI2 GLI3 GRB2 GSK3B GSTP1 HDAC1 HDAC2 HGF HHIP HIF1A HRAS HSP90AA1 HSP90AB1 HSP90B1 IGF1 IGF1R IKBKB IKBKG IL6 IL8 ITGA2 ITGA2B ITGA3 ITGA6 ITGAV ITGB1 JAK1 JUN JUP KIT KITLG KLK3 KRAS LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LEF1 LOC652346 LOC652671 LOC652799 MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MAX MDM2 MECOM MET MITF MLH1 MMP1 MMP2 MMP9 MSH2 MSH3 MSH6 MTOR MYC NCOA4 NFKB1 NFKB2 NFKBIA NKX3-1 NOS2 NRAS NTRK1 PAX8 PDGFA PDGFB PDGFRA PDGFRB PGF PIAS1 PIAS2 PIAS3 PIAS4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PLCG2 PLD1 PML PPARD PPARG PRKCA PRKCB PRKCG PTCH1 PTCH2 PTEN PTGS2 PTK2 RAC1 RAC2 RAC3 RAD51 RAF1 RALA RALB RALBP1 RALGDS RARA RARB RASSF1 RASSF5 RB1 RBX1 RELA RET RHOA RUNX1 RUNX1T1 RXRA RXRB RXRG SHH SKP2 SLC2A1 SMAD2 SMAD3 SMAD4 SMO SOS1 SOS2 SPI1 STAT1 STAT3 STAT5A STAT5B STK36 STK4 SUFU TCEB1 TCEB2 TCF7 TCF7L1 TCF7L2 TFG TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TP53 TPM3 TPR TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 VEGFA VEGFB VEGFC VHL WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XIAP ZBTB16 +KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Pentose and glucuronate interconversions AKR1B1 CRYL1 DCXR DHDH GUSB LOC729020 RPE UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 XYLB +KEGG_PENTOSE_PHOSPHATE_PATHWAY Pentose phosphate pathway ALDOA ALDOB ALDOC DERA FBP1 FBP2 G6PD GPI H6PD LOC729020 PFKL PFKM PFKP PGD PGLS PGM1 PGM2 PRPS1 PRPS1L1 PRPS2 RBKS RPE RPIA TALDO1 TKT TKTL1 TKTL2 +KEGG_PEROXISOME Peroxisome ABCD1 ABCD2 ABCD3 ABCD4 ACAA1 ACOT8 ACOX1 ACOX2 ACOX3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPS AGXT AMACR BAAT CAT CRAT CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EHHADH EPHX2 FAR1 FAR2 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HSD17B4 IDH1 IDH2 MLYCD MPV17 MPV17L MVK NOS2 NUDT12 NUDT19 PAOX PECR PEX1 PEX10 PEX11A PEX11B PEX11G PEX12 PEX13 PEX14 PEX16 PEX19 PEX2 PEX26 PEX3 PEX5 PEX6 PEX7 PHYH PIPOX PMVK PRDX1 PRDX5 PXMP2 PXMP4 SCP2 SLC25A17 SLC27A2 SOD1 SOD2 XDH +KEGG_PHENYLALANINE_METABOLISM Phenylalanine metabolism ALDH1A3 ALDH3A1 ALDH3B1 ALDH3B2 AOC2 AOC3 DDC GOT1 GOT2 HPD IL4I1 MAOA MAOB MIF NAT6 PAH PRDX6 TAT +KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Phosphatidylinositol signaling system CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CDIPT CDS1 CDS2 DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKQ DGKZ IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5D INPP5E INPP5J INPP5K INPPL1 IPPK ITPK1 ITPKA ITPKB ITPR1 ITPR2 ITPR3 OCRL PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIKFYVE PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKCA PRKCB PRKCG PTEN SYNJ1 SYNJ2 +KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Porphyrin and chlorophyll metabolism ALAD ALAS1 ALAS2 BLVRA BLVRB COX10 COX15 CP CPOX EARS2 EPRS FECH FTH1 FTMT GUSB HCCS HMBS HMOX1 HMOX2 MMAB PPOX UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UROD UROS +KEGG_PPAR_SIGNALING_PATHWAY PPAR signaling pathway ACAA1 ACADL ACADM ACOX1 ACOX2 ACOX3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ADIPOQ ANGPTL4 APOA1 APOA2 APOA5 APOC3 AQP7 CD36 CPT1A CPT1B CPT1C CPT2 CYP27A1 CYP4A11 CYP4A22 CYP7A1 CYP8B1 DBI EHHADH FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 FADS2 GK GK2 HMGCS2 ILK LPL ME1 MMP1 NR1H3 OLR1 PCK1 PCK2 PDPK1 PLIN1 PLTP PPARA PPARD PPARG RXRA RXRB RXRG SCD SCD5 SCP2 SLC27A1 SLC27A2 SLC27A4 SLC27A5 SLC27A6 SORBS1 UBC UCP1 +KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS Primary bile acid biosynthesis ACOX2 AKR1C4 AKR1D1 AMACR BAAT CH25H CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 SCP2 SLC27A5 +KEGG_PRIMARY_IMMUNODEFICIENCY Primary immunodeficiency ADA AICDA AIRE BLNK BTK CD19 CD3D CD3E CD4 CD40 CD40LG CD79A CD8A CD8B CIITA DCLRE1C ICOS IGLL1 IKBKG IL2RG IL7R JAK3 LCK PTPRC RAG1 RAG2 RFX5 RFXANK RFXAP TAP1 TAP2 TNFRSF13B TNFRSF13C UNG ZAP70 +KEGG_PRION_DISEASES Prion diseases BAX C1QA C1QB C1QC C5 C6 C7 C8A C8B C8G C9 CCL5 EGR1 ELK1 FYN HSPA1A HSPA5 IL1A IL1B IL6 LAMC1 MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NCAM2 NOTCH1 PRKACA PRKACB PRKACG PRKX PRNP SOD1 STIP1 +KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION Progesterone-mediated oocyte maturation ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 AKT2 AKT3 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ARAF BRAF BUB1 CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CDC16 CDC23 CDC25A CDC25B CDC25C CDC26 CDC27 CDK1 CDK2 CPEB1 FZR1 GNAI1 GNAI2 GNAI3 HSP90AA1 HSP90AB1 IGF1 IGF1R INS KRAS LOC650621 MAD2L1 MAD2L2 MAP2K1 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MOS PDE3A PDE3B PGR PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PKMYT1 PLK1 PRKACA PRKACB PRKACG PRKX RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 SPDYA SPDYC +KEGG_PROPANOATE_METABOLISM Propanoate metabolism ABAT ACACA ACACB ACADM ACAT1 ACAT2 ACSS1 ACSS2 ACSS3 ALDH1B1 ALDH2 ALDH3A2 ALDH6A1 ALDH7A1 ALDH9A1 ECHS1 EHHADH HADHA HIBCH LDHA LDHAL6A LDHAL6B LDHB LDHC LOC283398 MCEE MLYCD MUT PCCA PCCB SUCLA2 SUCLG1 SUCLG2 +KEGG_PROSTATE_CANCER Prostate cancer AKT1 AKT2 AKT3 AR ARAF ATF4 BAD BCL2 BRAF CASP9 CCND1 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B CHUK CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CREBBP CTNNB1 E2F1 E2F2 E2F3 EGF EGFR EP300 ERBB2 FGFR1 FGFR2 FOXO1 GRB2 GSK3B GSTP1 HRAS HSP90AA1 HSP90AB1 HSP90B1 IGF1 IGF1R IKBKB IKBKG INS INSRR KLK3 KRAS LEF1 MAP2K1 MAP2K2 MAPK1 MAPK3 MDM2 MTOR NFKB1 NFKBIA NKX3-1 NRAS PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTEN RAF1 RB1 RELA SOS1 SOS2 SRD5A2 TCF7 TCF7L1 TCF7L2 TGFA TP53 +KEGG_PROTEASOME Proteasome IFNG LOC100132108 LOC652826 POMP PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA6P4 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC1P4 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSME1 PSME2 PSME3 PSME4 PSMF1 SHFM1 +KEGG_PROTEIN_EXPORT Protein export HSPA5 IMMP1L IMMP2L OXA1L SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SEC62 SEC63 SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRP9P1 SRPR SRPRB +KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION Proximal tubule bicarbonate reclamation AQP1 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4 CA2 CA4 FXYD2 GLS GLS2 GLUD1 GLUD2 MDH1 PCK1 PCK2 SLC25A10 SLC38A3 SLC4A4 SLC9A3 +KEGG_PURINE_METABOLISM Purine metabolism ADA ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADK ADSL ADSS ADSSL1 AK1 AK2 AK4 AK5 AK7 ALLC AMPD1 AMPD2 AMPD3 APRT ATIC C17orf48 CANT1 DCK DGUOK ENPP1 ENPP3 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD8 FHIT GART GDA GMPR GMPR2 GMPS GUCY1A2 GUCY1A3 GUCY1B3 GUCY2C GUCY2D GUCY2F GUK1 HPRT1 IMPDH1 IMPDH2 ITPA NME1 NME1-NME2 NME2 NME3 NME4 NME5 NME6 NME7 NPR1 NPR2 NT5C NT5C1A NT5C1B NT5C2 NT5C3 NT5E NT5M NUDT2 NUDT5 NUDT9 PAICS PAPSS1 PAPSS2 PDE10A PDE11A PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE6A PDE6B PDE6C PDE6D PDE6G PDE6H PDE7A PDE7B PDE8A PDE8B PDE9A PFAS PKLR PKM2 PNP PNPT1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2J3 POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3F POLR3G POLR3GL POLR3H POLR3K PPAT PRHOXNB PRIM1 PRIM2 PRPS1 PRPS1L1 PRPS2 PRUNE RRM1 RRM2 RRM2B XDH ZNRD1 +KEGG_PYRIMIDINE_METABOLISM Pyrimidine metabolism AK3 CAD CANT1 CDA CMPK1 CMPK2 CTPS CTPS2 DCK DCTD DHODH DPYD DPYS DTYMK DUT ENTPD1 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD8 ITPA NME1 NME1-NME2 NME2 NME3 NME4 NME5 NME6 NME7 NT5C NT5C1A NT5C1B NT5C2 NT5C3 NT5E NT5M NUDT2 PNP PNPT1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2J3 POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3F POLR3G POLR3GL POLR3H POLR3K PRIM1 PRIM2 RRM1 RRM2 RRM2B TK1 TK2 TXNRD1 TXNRD2 TYMP TYMS UCK1 UCK2 UCKL1 UMPS UPB1 UPP1 UPP2 UPRT ZNRD1 +KEGG_PYRUVATE_METABOLISM Pyruvate metabolism ACACA ACACB ACAT1 ACAT2 ACOT12 ACSS1 ACSS2 ACYP1 ACYP2 AKR1B1 ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 DLAT DLD GLO1 GRHPR HAGH HAGHL LDHA LDHAL6A LDHAL6B LDHB LDHC LDHD MDH1 MDH2 ME1 ME2 ME3 PC PCK1 PCK2 PDHA1 PDHA2 PDHB PKLR PKM2 +KEGG_REGULATION_OF_ACTIN_CYTOSKELETON Regulation of actin cytoskeleton ABI2 ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 APC APC2 ARAF ARHGAP35 ARHGEF1 ARHGEF12 ARHGEF4 ARHGEF6 ARHGEF7 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L BAIAP2 BCAR1 BDKRB1 BDKRB2 BRAF BRK1 CD14 CDC42 CFL1 CFL2 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRK CRKL CSK CYFIP1 CYFIP2 DIAPH1 DIAPH2 DIAPH3 DOCK1 EGF EGFR ENAH EZR F2 F2R FGD1 FGD3 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FN1 GIT1 GNA12 GNA13 GNG12 GSN HRAS INS INSRR IQGAP1 IQGAP2 IQGAP3 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KRAS LIMK1 LIMK2 LOC100418883 LOC646821 LOC653888 MAP2K1 MAP2K2 MAPK1 MAPK3 MOS MRAS MSN MYH10 MYH14 MYH9 MYL10 MYL12A MYL12B MYL2 MYL5 MYL7 MYL9 MYLK MYLK2 MYLK3 MYLPF NCKAP1 NCKAP1L NRAS PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PFN1 PFN2 PFN3 PFN4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIKFYVE PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PPP1CA PPP1CB PPP1CC PPP1R12A PTK2 PXN RAC1 RAC2 RAC3 RAF1 RDX RHOA ROCK1 ROCK2 RRAS RRAS2 SCIN SLC9A1 SOS1 SOS2 SSH1 SSH2 SSH3 TIAM1 TIAM2 TMSB4X TMSB4Y TMSL3 VAV1 VAV2 VAV3 VCL WAS WASF1 WASF2 WASL +KEGG_REGULATION_OF_AUTOPHAGY Regulation of autophagy ATG12 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 BECN1 BECN1P1 GABARAP GABARAPL1 GABARAPL2 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNG INS PIK3C3 PIK3R4 PRKAA1 PRKAA2 ULK1 ULK2 ULK3 +KEGG_RENAL_CELL_CARCINOMA Renal cell carcinoma AKT1 AKT2 AKT3 ARAF ARNT ARNT2 BRAF CDC42 CREBBP CRK CRKL CUL2 EGLN1 EGLN2 EGLN3 EP300 EPAS1 ETS1 FH FIGF FLCN GAB1 GRB2 HGF HIF1A HRAS JUN KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MET NRAS PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PDGFB PGF PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTPN11 RAC1 RAF1 RAP1A RAP1B RAPGEF1 RBX1 SLC2A1 SOS1 SOS2 TCEB1 TCEB2 TGFA TGFB1 TGFB2 TGFB3 VEGFA VEGFB VEGFC VHL +KEGG_RENIN_ANGIOTENSIN_SYSTEM Renin-angiotensin system ACE ACE2 AGT AGTR1 AGTR2 ANPEP CMA1 CPA3 CTSA CTSG ENPEP LNPEP MAS1 MME NLN REN THOP1 +KEGG_RETINOL_METABOLISM Retinol metabolism ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ALDH1A1 ALDH1A2 AWAT2 BCMO1 CYP1A1 CYP1A2 CYP26A1 CYP26B1 CYP26C1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP4A11 CYP4A22 DGAT1 DGAT2 DHRS3 DHRS4 DHRS4L2 DHRS9 LRAT PNPLA4 RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RETSAT RPE65 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +KEGG_RIBOFLAVIN_METABOLISM Riboflavin metabolism ACP1 ACP2 ACP5 ACP6 ACPP ACPT ENPP1 ENPP3 FLAD1 MTMR1 MTMR2 MTMR6 MTMR7 PHPT1 RFK TYR +KEGG_RIBOSOME Ribosome FAU MRPL13 RPL10 RPL10A RPL10L RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL36AL RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RSL24D1 RSL24D1P11 UBA52 +KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY RIG-I-like receptor signaling pathway ATG12 ATG5 AZI2 CASP10 CASP8 CHUK CXCL10 CYLD DAK DDX3X DDX3Y DDX58 DHX58 FADD IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNE IFNK IFNW1 IKBKB IKBKE IKBKG IL12A IL12B IL8 IRF3 IRF7 ISG15 MAP3K1 MAP3K7 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAVS NFKB1 NFKBIA NFKBIB NLRX1 OTUD5 PIN1 RELA RIPK1 RNF125 SIKE1 TANK TBK1 TBKBP1 TMEM173 TNF TRADD TRAF2 TRAF3 TRAF6 TRIM25 +KEGG_RNA_DEGRADATION RNA degradation C1D C1DP2 C1DP3 CNOT1 CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 DCP1A DCP1B DCP2 DCPS DDX6 DIS3 EDC3 EDC4 ENO1 ENO2 ENO3 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HSPA9 HSPD1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MPHOSPH6 NAA38 PAPD7 PAPOLA PAPOLB PAPOLG PARN PATL1 PNPT1 RQCD1 SKIV2L SKIV2L2 TTC37 WDR61 XRN1 XRN2 ZCCHC7 +KEGG_RNA_POLYMERASE RNA polymerase POLR1A POLR1B POLR1C POLR1D POLR1E POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2J3 POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3F POLR3G POLR3GL POLR3H POLR3K ZNRD1 +KEGG_SELENOAMINO_ACID_METABOLISM Selenoamino acid metabolism AHCY AHCYL1 AHCYL2 CBS CTH GGT1 GGT5 GGT6 GGT7 HEMK1 LCMT1 LCMT2 MARS MARS2 MAT1A MAT2A MAT2B METTL2B METTL6 PAPSS1 PAPSS2 SCLY SEPHS1 SEPHS2 TRMT11 WBSCR22 +KEGG_SMALL_CELL_LUNG_CANCER Small cell lung cancer AKT1 AKT2 AKT3 APAF1 BCL2 BCL2L1 BIRC2 BIRC3 CASP9 CCND1 CCNE1 CCNE2 CDK2 CDK4 CDK6 CDKN1B CDKN2B CHUK CKS1B COL4A1 COL4A2 COL4A4 COL4A6 CYCS E2F1 E2F2 E2F3 FHIT FN1 IKBKB IKBKG ITGA2 ITGA2B ITGA3 ITGA6 ITGAV ITGB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 MAX MYC NFKB1 NFKBIA NOS2 PIAS1 PIAS2 PIAS3 PIAS4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PTEN PTGS2 PTK2 RARB RB1 RELA RXRA RXRB RXRG SKP2 TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 XIAP +KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT SNARE interactions in vesicular transport BET1 BET1L BNIP1 GOSR1 GOSR2 SEC22B SNAP23 SNAP25 SNAP29 SNAP47 STX10 STX11 STX12 STX16 STX17 STX18 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 TSNARE1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VTI1A VTI1B YKT6 +KEGG_SPHINGOLIPID_METABOLISM Sphingolipid metabolism ACER1 ACER2 ACER3 ARSA ASAH1 ASAH2 ASAH2C B4GALT6 CERK DEGS1 DEGS2 ENPP7 GAL3ST1 GALC GBA GLA GLB1 KDSR NEU1 NEU2 NEU3 NEU4 PPAP2A PPAP2B PPAP2C SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPTLC1 SPTLC2 UGCG UGT8 +KEGG_SPLICEOSOME Spliceosome ACIN1 AQR BCAS2 BUD31 CCDC12 CDC40 CDC5L CHERP CRNKL1 CTNNBL1 CWC15 DDX23 DDX39B DDX42 DDX46 DDX5 DHX15 DHX16 DHX38 DHX8 EFTUD2 EIF4A3 HNRNPA1 HNRNPA1L2 HNRNPA3 HNRNPC HNRNPK HNRNPM HNRNPU HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 ISY1 LOC120364 LOC653884 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGOH MAGOHB NAA38 NCBP1 NCBP2 NHP2L1 PCBP1 PHF5A PLRG1 PPIE PPIH PPIL1 PQBP1 PRPF18 PRPF19 PRPF3 PRPF31 PRPF38A PRPF38B PRPF4 PRPF40A PRPF40B PRPF6 PRPF8 PUF60 RBM17 RBM22 RBM25 RBM8A RBMX SART1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SLU7 SMNDC1 SNRNP200 SNRNP27 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNW1 SRSF1 SRSF10 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 SYF2 TCERG1 THOC1 THOC2 THOC3 THOC4 TRA2A TRA2B TXNL4A U2AF1 U2AF2 U2SURP USP39 WBP11 XAB2 ZMAT2 +KEGG_STARCH_AND_SUCROSE_METABOLISM Starch and sucrose metabolism AGL AMY1A AMY1B AMY1C AMY2A AMY2B ENPP1 ENPP3 G6PC G6PC2 GAA GANC GBA3 GBE1 GCK GPI GUSB GYS1 GYS2 HK1 HK2 HK3 MGAM PGM1 PGM2 PGM2L1 PYGB PYGL PYGM SI TREH UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UXS1 +KEGG_STEROID_BIOSYNTHESIS Steroid biosynthesis CEL CYP27B1 CYP51A1 DHCR24 DHCR7 EBP FDFT1 HSD17B7 LIPA LSS MSMO1 NSDHL SC5DL SOAT1 SOAT2 SQLE TM7SF2 +KEGG_STEROID_HORMONE_BIOSYNTHESIS Steroid hormone biosynthesis AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 COMT CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1B1 CYP21A2 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP7A1 CYP7B1 HSD11B1 HSD11B2 HSD17B1 HSD17B12 HSD17B2 HSD17B3 HSD17B6 HSD17B7 HSD17B8 HSD3B1 HSD3B2 SRD5A1 SRD5A2 SRD5A3 STS SULT1E1 SULT2B1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +KEGG_SULFUR_METABOLISM Sulfur metabolism BPNT1 CHST11 CHST12 CHST13 PAPSS1 PAPSS2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1E1 SULT2B1 SUOX +KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS Systemic lupus erythematosus ACTN1 ACTN2 ACTN3 ACTN4 C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C8B C8G C9 CD28 CD40 CD40LG CD80 CD86 CTSG ELANE FCGR1A FCGR2A FCGR2B FCGR2C FCGR3A FCGR3B GRIN2A GRIN2B H2AFB1 H2AFB2 H2AFB3 H2AFJ H2AFV H2AFX H2AFY H2AFY2 H2AFZ H2BFM H2BFWT H3.X H3.Y H3F3A H3F3B H3F3C HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H2APS6 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4G HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IFNG IL10 LOC644950 SNRPB SNRPD1 SNRPD3 SSB TNF TRIM21 TROVE2 +KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY T cell receptor signaling pathway AKT1 AKT2 AKT3 BCL10 CARD11 CBL CBLB CBLC CD247 CD28 CD3D CD3E CD3G CD4 CD40LG CD8A CD8B CDC42 CDK4 CHP CHP2 CHUK CSF2 CTLA4 DLG1 FOS FYN GRAP2 GRB2 GSK3B HRAS ICOS IFNG IKBKB IKBKG IL10 IL2 IL4 IL5 ITK JUN KRAS LAT LCK LCP2 MALT1 MAP2K1 MAP2K2 MAP2K7 MAP3K14 MAP3K7 MAP3K8 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK9 NCK1 NCK2 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PDCD1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCG1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ PTPN6 PTPRC RAF1 RASGRP1 RELA RHOA SOS1 SOS2 TEC TNF VAV1 VAV2 VAV3 ZAP70 +KEGG_TASTE_TRANSDUCTION Taste transduction ACCN1 ADCY4 ADCY6 ADCY8 CACNA1A CACNA1B GNAS GNAT3 GNB1 GNB3 GNG13 GNG3 GRM4 ITPR3 KCNB1 PDE1A PLCB2 PRKACA PRKACB PRKACG PRKX SCNN1A SCNN1B SCNN1G TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TRPM5 +KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM Taurine and hypotaurine metabolism ADO BAAT CDO1 CSAD GAD1 GAD2 GGT1 GGT5 GGT6 GGT7 +KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS Terpenoid backbone biosynthesis ACAT1 ACAT2 DHDDS FDPS GGPS1 HMGCR HMGCS1 HMGCS2 IDI1 IDI2 MVD MVK PDSS1 PDSS2 PMVK +KEGG_TGF_BETA_SIGNALING_PATHWAY TGF-beta signaling pathway ACVR1 ACVR1C ACVR2A ACVR2B ACVRL1 AMH AMHR2 BMP2 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B BMPR1A BMPR1B BMPR2 CDKN2B CHRD COMP CREBBP CUL1 DCN E2F4 E2F5 EP300 FST GDF5 GDF6 GDF7 ID1 ID2 ID3 ID4 IFNG INHBA INHBB INHBC INHBE LEFTY1 LEFTY2 LOC728622 LTBP1 MAPK1 MAPK3 MYC NODAL NOG PITX2 PPP2CA PPP2CB PPP2R1A PPP2R1B RBL1 RBL2 RBX1 RHOA ROCK1 ROCK2 RPS6KB1 RPS6KB2 SKP1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 SP1 TFDP1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 THBS1 THBS2 THBS3 THBS4 TNF ZFYVE16 ZFYVE9 +KEGG_THYROID_CANCER Thyroid cancer BRAF CCDC6 CCND1 CDH1 CTNNB1 HRAS KRAS LEF1 MAP2K1 MAP2K2 MAPK1 MAPK3 MYC NCOA4 NRAS NTRK1 PAX8 PPARG RET RXRA RXRB RXRG TCF7 TCF7L1 TCF7L2 TFG TP53 TPM3 TPR +KEGG_TIGHT_JUNCTION Tight junction ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 AKT1 AKT2 AKT3 AMOTL1 ASH1L CASK CDC42 CDK4 CGN CLDN1 CLDN10 CLDN11 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 CSDA CSNK2A1 CSNK2A2 CSNK2B CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTTN EPB41 EPB41L1 EPB41L2 EPB41L3 EXOC3 EXOC4 F11R GNAI1 GNAI2 GNAI3 HCLS1 HRAS IGSF5 INADL JAM2 JAM3 KRAS LLGL1 LLGL2 LOC100418883 LOC646821 MAGI1 MAGI2 MAGI3 MLLT4 MPDZ MPP5 MRAS MYH1 MYH10 MYH11 MYH13 MYH14 MYH15 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYL10 MYL12A MYL12B MYL2 MYL5 MYL7 MYL9 MYLPF NRAS OCLN PARD3 PARD6A PARD6B PARD6G PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R2D PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PTEN RAB13 RAB3B RHOA RRAS RRAS2 SPTAN1 SRC SYMPK TJAP1 TJP1 TJP2 TJP3 VAPA YES1 ZAK +KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Toll-like receptor signaling pathway AKT1 AKT2 AKT3 CASP8 CCL3 CCL4 CCL5 CD14 CD40 CD80 CD86 CHUK CTSK CXCL10 CXCL11 CXCL9 FADD FOS IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IKBKB IKBKE IKBKG IL12A IL12B IL1B IL6 IL8 IRAK1 IRAK4 IRF3 IRF5 IRF7 JUN LBP LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 RAC1 RELA RIPK1 SPP1 STAT1 TAB1 TAB2 TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TOLLIP TRAF3 TRAF6 +KEGG_TRYPTOPHAN_METABOLISM Tryptophan metabolism AADAT AANAT ABP1 ACAT1 ACAT2 ACMSD AFMID ALDH1B1 ALDH2 ALDH3A2 ALDH7A1 ALDH9A1 AOX1 ASMT CAT CYP1A1 CYP1A2 CYP1B1 DDC ECHS1 EHHADH GCDH HAAO HADH HADHA IDO1 IDO2 IL4I1 INMT KMO KYNU MAOA MAOB OGDH OGDHL TDO2 TPH1 TPH2 WARS WARS2 +KEGG_TYPE_I_DIABETES_MELLITUS Type I diabetes mellitus CD28 CD80 CD86 CPE FAS FASLG GAD1 GAD2 GZMB HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G HSPD1 ICA1 IFNG IL12A IL12B IL1A IL1B IL2 INS LOC652614 LTA PRF1 PTPRN PTPRN2 TNF +KEGG_TYPE_II_DIABETES_MELLITUS Type II diabetes mellitus ABCC8 ADIPOQ CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1G GCK HK1 HK2 HK3 IKBKB INS INSR IRS1 IRS2 IRS4 KCNJ11 MAFA MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MTOR PDX1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PKLR PKM2 PRKCD PRKCE PRKCZ SLC2A2 SLC2A4 SOCS1 SOCS2 SOCS3 SOCS4 TNF +KEGG_TYROSINE_METABOLISM Tyrosine metabolism ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ALDH1A3 ALDH3A1 ALDH3B1 ALDH3B2 AOC2 AOC3 AOX1 COMT DBH DCT DDC FAH GOT1 GOT2 GSTZ1 HEMK1 HGD HPD IL4I1 LCMT1 LCMT2 MAOA MAOB METTL2B METTL6 MIF NAT6 PNMT TAT TH TPO TRMT11 TYR TYRP1 WBSCR22 +KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS Ubiquitin mediated proteolysis AIRE ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BIRC2 BIRC3 BIRC6 BRCA1 BTRC CBL CBLB CBLC CDC16 CDC20 CDC23 CDC26 CDC27 CDC34 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 DDB1 DDB2 DET1 ERCC8 FANCL FBXO2 FBXO4 FBXW11 FBXW7 FBXW8 FZR1 HERC1 HERC2 HERC3 HERC4 HUWE1 ITCH KEAP1 KLHL13 KLHL9 LOC650621 LOC652346 LOC652671 LOC728622 MAP3K1 MDM2 MGRN1 MID1 NEDD4 NEDD4L NHLRC1 PARK2 PIAS1 PIAS2 PIAS3 PIAS4 PML PPIL2 PRPF19 RBX1 RCHY1 RFWD2 RHOBTB2 RNF7 SAE1 SIAH1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 STUB1 SYVN1 TCEB1 TCEB2 TRAF6 TRIM32 TRIM37 TRIP12 UBA1 UBA2 UBA3 UBA6 UBA7 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2I UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2NL UBE2O UBE2Q1 UBE2Q2 UBE2QL1 UBE2R2 UBE2S UBE2U UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBE4B UBOX5 UBR5 VHL WWP1 WWP2 XIAP +KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Valine, leucine and isoleucine biosynthesis BCAT1 BCAT2 IARS IARS2 LARS LARS2 PDHA1 PDHA2 PDHB VARS VARS2 +KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Valine, leucine and isoleucine degradation ABAT ACAA1 ACAA2 ACAD8 ACADM ACADS ACADSB ACAT1 ACAT2 ALDH1B1 ALDH2 ALDH3A2 ALDH6A1 ALDH7A1 ALDH9A1 AOX1 AUH BCAT1 BCAT2 BCKDHA BCKDHB DBT DLD ECHS1 EHHADH HADH HADHA HADHB HIBADH HIBCH HMGCL HMGCS1 HMGCS2 HSD17B10 IL4I1 IVD MCCC1 MCCC2 MCEE MUT OXCT1 OXCT2 PCCA PCCB +KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION Vascular smooth muscle contraction ACTA2 ACTG2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2A ADORA2B ADRA1A ADRA1B ADRA1D AGTR1 ARAF ARHGEF1 ARHGEF11 ARHGEF12 AVPR1A AVPR1B BRAF CACNA1C CACNA1D CACNA1F CACNA1S CALCRL CALD1 CALM1 CALM2 CALM3 CALML3 CALML5 CALML6 CYP4A11 CYP4A22 EDNRA GNA11 GNA12 GNA13 GNAQ GNAS GUCY1A2 GUCY1A3 GUCY1B3 ITPR1 ITPR2 ITPR3 JMJD7-PLA2G4B KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 MAP2K1 MAP2K2 MAPK1 MAPK3 MRVI1 MYH11 MYL6 MYL6B MYL9 MYLK MYLK2 MYLK3 NPR1 NPR2 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLCB1 PLCB2 PLCB3 PLCB4 PPP1CA PPP1CB PPP1CC PPP1R12A PPP1R12B PPP1R14A PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKG1 PRKX PTGIR RAF1 RAMP1 RAMP2 RAMP3 RHOA ROCK1 ROCK2 +KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION Vasopressin-regulated water reabsorption ADCY3 ADCY6 ADCY9 AQP2 AQP3 AQP4 ARHGDIA ARHGDIB AVP AVPR2 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 DCTN1 DCTN2 DCTN4 DCTN5 DCTN6 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 GNAS NSF PRKACA PRKACB PRKACG PRKX RAB11A RAB11B RAB5A RAB5B RAB5C STX4 VAMP2 +KEGG_VEGF_SIGNALING_PATHWAY VEGF signaling pathway AKT1 AKT2 AKT3 BAD CASP9 CDC42 CHP CHP2 HRAS HSPB1 JMJD7-PLA2G4B KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NOS3 NRAS PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4E PLA2G5 PLA2G6 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCG PTGS2 PTK2 PXN RAC1 RAC2 RAC3 RAF1 SH2D2A SHC2 SPHK1 SPHK2 SRC VEGFA +KEGG_VIBRIO_CHOLERAE_INFECTION Vibrio cholerae infection ACTB ACTG1 ADCY3 ADCY9 ARF1 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CFTR ERO1L GNAS KCNQ1 KDELR1 KDELR2 KDELR3 LOC100418883 LOC646821 MUC2 PDIA4 PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX SEC61A1 SEC61A2 SEC61B SEC61G SLC12A2 TCIRG1 TJP1 TJP2 +KEGG_VIRAL_MYOCARDITIS Viral myocarditis ABL1 ABL2 ACTB ACTG1 BID CASP3 CASP8 CASP9 CAV1 CCND1 CD28 CD40 CD40LG CD55 CD80 CD86 CXADR CYCS DAG1 DMD EIF4G1 EIF4G2 EIF4G3 FYN HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G ICAM1 ITGAL ITGB2 LAMA2 LOC100418883 LOC646821 LOC652614 MYH1 MYH10 MYH11 MYH13 MYH14 MYH15 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 PRF1 RAC1 RAC2 RAC3 SGCA SGCB SGCD SGCG +KEGG_WNT_SIGNALING_PATHWAY Wnt signaling pathway APC APC2 AXIN1 AXIN2 BTRC CACYBP CAMK2A CAMK2B CAMK2D CAMK2G CCND1 CCND2 CCND3 CER1 CHD8 CHP CHP2 CREBBP CSNK1A1 CSNK1A1L CSNK1E CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTBP2 CTNNB1 CTNNBIP1 CUL1 CXXC4 DAAM1 DAAM2 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FBXW11 FOSL1 FRAT1 FRAT2 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GSK3B JUN LEF1 LOC728622 LRP5 LRP6 MAP3K7 MAPK10 MAPK8 MAPK9 MMP7 MYC NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NKD1 NKD2 NLK PLCB1 PLCB2 PLCB3 PLCB4 PORCN PPARD PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRICKLE1 PRICKLE2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PRKX PSEN1 RAC1 RAC2 RAC3 RBX1 RHOA ROCK1 ROCK2 RUVBL1 SENP2 SFRP1 SFRP2 SFRP4 SFRP5 SIAH1 SKP1 SMAD2 SMAD3 SMAD4 SOX17 TBL1X TBL1XR1 TBL1Y TCF7 TCF7L1 TCF7L2 TP53 VANGL1 VANGL2 WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B +NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes AGRN COL15A1 COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COLQ HMCN1 HSPG2 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 NID1 NID2 NPNT NTN1 NTN3 NTN4 NTN5 NTNG1 NTNG2 PAPLN USH2A +NABA_COLLAGENS Genes encoding collagen proteins COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 +NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans ABI3BP ACAN ADIPOQ AEBP1 AGRN AMBN AMELX AMELY ASPN BCAN BGLAP BGN BMPER BSPH1 CDCP2 CHAD CHADL CILP CILP2 COCH COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLQ COMP CRELD1 CRELD2 CRIM1 CRISPLD1 CRISPLD2 CTGF CTHRC1 CYR61 DCN DDX26B DMBT1 DMP1 DPT DSPP ECM1 ECM2 EDIL3 EFEMP1 EFEMP2 EGFLAM ELN ELSPBP1 EMID1 EMILIN1 EMILIN2 EMILIN3 EPYC ESM1 EYS FBLN1 FBLN2 FBLN5 FBLN7 FBN1 FBN2 FBN3 FGA FGB FGG FGL1 FGL2 FMOD FN1 FNDC1 FNDC7 FNDC8 FRAS1 GAS6 GLDN HAPLN1 HAPLN2 HAPLN3 HAPLN4 HMCN1 HMCN2 HSPG2 IBSP IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGFBPL1 IGSF10 IMPG1 IMPG2 KAL1 KCP KERA LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LGI1 LGI2 LGI3 LGI4 LRG1 LTBP1 LTBP2 LTBP3 LTBP4 LUM MATN1 MATN2 MATN3 MATN4 MEPE MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 MFGE8 MGP MMRN1 MMRN2 MXRA5 NCAN NDNF NELL1 NELL2 NID1 NID2 NOV NPNT NTN1 NTN3 NTN4 NTN5 NTNG1 NTNG2 NYX OGN OIT3 OMD OPTC OTOG OTOL1 PAPLN PCOLCE PCOLCE2 PODN PODNL1 POMZP3 POSTN PRELP PRG2 PRG3 PRG4 PXDN PXDNL RELN RSPO1 RSPO2 RSPO3 RSPO4 SBSPON SLIT1 SLIT2 SLIT3 SMOC1 SMOC2 SNED1 SPARC SPARCL1 SPOCK1 SPOCK2 SPOCK3 SPON1 SPON2 SPP1 SRGN SRPX SRPX2 SSPO SVEP1 TECTA TECTB TGFBI THBS1 THBS2 THBS3 THBS4 THSD4 TINAG TINAGL1 TNC TNFAIP6 TNN TNR TNXB TSKU TSPEAR USH2A VCAN VIT VTN VWA1 VWA2 VWA3A VWA3B VWA5A VWA5B1 VWA5B2 VWA7 VWA9 VWCE VWDE VWF WISP1 WISP2 WISP3 ZP1 ZP2 ZP3 ZP4 ZPLD1 +NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins ANXA1 ANXA10 ANXA11 ANXA13 ANXA2 ANXA3 ANXA4 ANXA5 ANXA6 ANXA7 ANXA8 ANXA8L1 ANXA9 C1QA C1QB C1QC C1QL1 C1QL2 C1QL3 C1QL4 C1QTNF1 C1QTNF2 C1QTNF3 C1QTNF4 C1QTNF5 C1QTNF6 C1QTNF7 C1QTNF8 C1QTNF9 CD209 CLC CLEC10A CLEC11A CLEC12A CLEC12B CLEC14A CLEC17A CLEC18A CLEC18B CLEC18C CLEC19A CLEC1A CLEC1B CLEC2A CLEC2B CLEC2D CLEC2L CLEC3A CLEC3B CLEC4A CLEC4C CLEC4D CLEC4E CLEC4F CLEC4G CLEC4M CLEC5A CLEC6A CLEC7A CLEC9A COLEC10 COLEC11 COLEC12 CSPG4 CSPG5 ELFN1 ELFN2 EMCN FCN1 FCN2 FCN3 FREM1 FREM2 FREM3 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GREM1 GRIFIN HPX ITLN1 ITLN2 LGALS1 LGALS12 LGALS13 LGALS14 LGALS16 LGALS2 LGALS3 LGALS4 LGALS7 LGALS8 LGALS9 LGALS9B LGALS9C LGALSL LMAN1 LMAN1L MBL2 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC22 MUC3A MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUCL1 OVGP1 PARM1 PLXDC1 PLXDC2 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB2 PLXNB3 PLXNC1 PLXND1 PROL1 REG1A REG1B REG3A REG3G REG4 SDC1 SDC2 SDC3 SDC4 SEMA3A SEMA3B SEMA3C SEMA3D SEMA3E SEMA3F SEMA3G SEMA4A SEMA4B SEMA4C SEMA4D SEMA4F SEMA4G SEMA5A SEMA5B SEMA6A SEMA6B SEMA6C SEMA6D SEMA7A SFTA2 SFTA3 SFTPA1 SFTPA2 SFTPB SFTPC SFTPD +NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins ABI3BP ADIPOQ AEBP1 AGRN AMBN AMELX AMELY BGLAP BMPER BSPH1 CDCP2 CILP CILP2 COCH COLQ COMP CRELD1 CRELD2 CRIM1 CRISPLD1 CRISPLD2 CTGF CTHRC1 CYR61 DDX26B DMBT1 DMP1 DPT DSPP ECM1 ECM2 EDIL3 EFEMP1 EFEMP2 EGFLAM ELN ELSPBP1 EMID1 EMILIN1 EMILIN2 EMILIN3 EYS FBLN1 FBLN2 FBLN5 FBLN7 FBN1 FBN2 FBN3 FGA FGB FGG FGL1 FGL2 FN1 FNDC1 FNDC7 FNDC8 FRAS1 GAS6 GLDN HMCN1 HMCN2 IBSP IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGFBPL1 IGSF10 KAL1 KCP LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LGI1 LGI2 LGI3 LGI4 LRG1 LTBP1 LTBP2 LTBP3 LTBP4 MATN1 MATN2 MATN3 MATN4 MEPE MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 MFGE8 MGP MMRN1 MMRN2 MXRA5 NDNF NELL1 NELL2 NID1 NID2 NOV NPNT NTN1 NTN3 NTN4 NTN5 NTNG1 NTNG2 OIT3 OTOG OTOL1 PAPLN PCOLCE PCOLCE2 POMZP3 POSTN PXDN PXDNL RELN RSPO1 RSPO2 RSPO3 RSPO4 SBSPON SLIT1 SLIT2 SLIT3 SMOC1 SMOC2 SNED1 SPARC SPARCL1 SPON1 SPON2 SPP1 SRPX SRPX2 SSPO SVEP1 TECTA TECTB TGFBI THBS1 THBS2 THBS3 THBS4 THSD4 TINAG TINAGL1 TNC TNFAIP6 TNN TNR TNXB TSKU TSPEAR USH2A VIT VTN VWA1 VWA2 VWA3A VWA3B VWA5A VWA5B1 VWA5B2 VWA7 VWA9 VWCE VWDE VWF WISP1 WISP2 WISP3 ZP1 ZP2 ZP3 ZP4 ZPLD1 +NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix A2M A2ML1 ADAM10 ADAM11 ADAM12 ADAM15 ADAM17 ADAM18 ADAM19 ADAM2 ADAM20 ADAM21 ADAM22 ADAM23 ADAM28 ADAM29 ADAM30 ADAM32 ADAM33 ADAM7 ADAM8 ADAM9 ADAMDEC1 ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 AGT AMBP ASTL BMP1 C17orf58 CD109 CELA1 CELA2A CELA2B CELA3A CELA3B CPAMD8 CPN2 CST1 CST11 CST2 CST3 CST4 CST5 CST6 CST7 CST8 CST9 CST9L CSTA CSTB CSTL1 CTSA CTSB CTSC CTSD CTSE CTSF CTSG CTSH CTSK CTSL CTSO CTSS CTSV CTSW CTSZ EGLN1 EGLN2 EGLN3 ELANE F10 F12 F13A1 F13B F2 F7 F9 FAM20A FAM20B FAM20C HABP2 HMSD HPSE HPSE2 HRG HTRA1 HTRA3 HTRA4 HYAL1 HYAL2 HYAL3 HYAL4 ITIH1 ITIH2 ITIH3 ITIH4 ITIH5 ITIH6 KAZALD1 KNG1 KY LOX LOXL1 LOXL2 LOXL3 LOXL4 LPA MASP1 MASP2 MEP1A MEP1B MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 NGLY1 OGFOD1 OGFOD2 P3H1 P3H2 P3H3 P4HA1 P4HA2 P4HA3 P4HTM PAMR1 PAPPA PAPPA2 PCSK5 PCSK6 PI3 PLAT PLAU PLG PLOD1 PLOD2 PLOD3 PRSS1 PRSS12 PRSS2 PRSS3 PZP SERPINA1 SERPINA10 SERPINA11 SERPINA12 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA9 SERPINB1 SERPINB10 SERPINB11 SERPINB12 SERPINB13 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE3 SERPINF1 SERPINF2 SERPING1 SERPINH1 SERPINI1 SERPINI2 SLPI SPAM1 ST14 SULF1 SULF2 TGM1 TGM2 TGM3 TGM4 TGM5 TGM6 TGM7 TIMP1 TIMP2 TIMP3 TIMP4 TLL1 TLL2 TMPRSS15 +NABA_MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins A2M A2ML1 ABI3BP ACAN ADAM10 ADAM11 ADAM12 ADAM15 ADAM17 ADAM18 ADAM19 ADAM2 ADAM20 ADAM21 ADAM22 ADAM23 ADAM28 ADAM29 ADAM30 ADAM32 ADAM33 ADAM7 ADAM8 ADAM9 ADAMDEC1 ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADIPOQ AEBP1 AGRN AGT AMBN AMBP AMELX AMELY AMH ANGPT1 ANGPT2 ANGPT4 ANGPTL1 ANGPTL2 ANGPTL3 ANGPTL4 ANGPTL5 ANGPTL6 ANGPTL7 ANXA1 ANXA10 ANXA11 ANXA13 ANXA2 ANXA3 ANXA4 ANXA5 ANXA6 ANXA7 ANXA8 ANXA8L1 ANXA9 AREG ARTN ASPN ASTL BCAN BDNF BGLAP BGN BMP1 BMP10 BMP15 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B BMPER BRINP2 BRINP3 BSPH1 BTC C17orf58 C1QA C1QB C1QC C1QL1 C1QL2 C1QL3 C1QL4 C1QTNF1 C1QTNF2 C1QTNF3 C1QTNF4 C1QTNF5 C1QTNF6 C1QTNF7 C1QTNF8 C1QTNF9 C1QTNF9B CBLN1 CBLN2 CBLN3 CBLN4 CCBE1 CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CD109 CD209 CDCP2 CELA1 CELA2A CELA2B CELA3A CELA3B CFC1 CFC1B CHAD CHADL CHRD CHRDL1 CHRDL2 CILP CILP2 CLC CLCF1 CLEC10A CLEC11A CLEC12A CLEC12B CLEC14A CLEC17A CLEC18A CLEC18B CLEC18C CLEC19A CLEC1A CLEC1B CLEC2A CLEC2B CLEC2D CLEC2L CLEC3A CLEC3B CLEC4A CLEC4C CLEC4D CLEC4E CLEC4F CLEC4G CLEC4M CLEC5A CLEC6A CLEC7A CLEC9A CNTF COCH COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLEC10 COLEC11 COLEC12 COLQ COMP CPAMD8 CPN2 CRELD1 CRELD2 CRHBP CRIM1 CRISPLD1 CRISPLD2 CRLF1 CRLF3 CRNN CSF1 CSF2 CSF3 CSH1 CSH2 CSHL1 CSPG4 CSPG5 CST1 CST11 CST2 CST3 CST4 CST5 CST6 CST7 CST8 CST9 CST9L CSTA CSTB CSTL1 CTF1 CTGF CTHRC1 CTSA CTSB CTSC CTSD CTSE CTSF CTSG CTSH CTSK CTSL CTSO CTSS CTSV CTSW CTSZ CX3CL1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CYR61 DCN DDX26B DHH DMBT1 DMP1 DPT DSPP EBI3 ECM1 ECM2 EDA EDIL3 EFEMP1 EFEMP2 EGF EGFL6 EGFL7 EGFL8 EGFLAM EGLN1 EGLN2 EGLN3 ELANE ELFN1 ELFN2 ELN ELSPBP1 EMCN EMID1 EMILIN1 EMILIN2 EMILIN3 EPGN EPO EPYC EREG ESM1 EYS F10 F12 F13A1 F13B F2 F7 F9 FAM20A FAM20B FAM20C FASLG FBLN1 FBLN2 FBLN5 FBLN7 FBN1 FBN2 FBN3 FCN1 FCN2 FCN3 FGA FGB FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FGG FGL1 FGL2 FIGF FLG FLG2 FLT3LG FMOD FN1 FNDC1 FNDC7 FNDC8 FRAS1 FREM1 FREM2 FREM3 FRZB FST FSTL1 FSTL3 GAS6 GDF1 GDF10 GDF11 GDF15 GDF2 GDF3 GDF5 GDF6 GDF7 GDF9 GDNF GH1 GH2 GLDN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GREM1 GRIFIN HABP2 HAPLN1 HAPLN2 HAPLN3 HAPLN4 HBEGF HCFC1 HCFC2 HGF HGFAC HHIP HMCN1 HMCN2 HMSD HPSE HPSE2 HPX HRG HRNR HSPG2 HTRA1 HTRA3 HTRA4 HYAL1 HYAL2 HYAL3 HYAL4 IBSP IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNE IFNG IFNK IFNW1 IGF1 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGFBPL1 IGSF10 IHH IL10 IL11 IL12A IL12B IL13 IL15 IL16 IL17A IL17B IL17C IL17D IL17F IL18 IL19 IL1A IL1B IL1F10 IL1RN IL2 IL20 IL22 IL23A IL24 IL25 IL26 IL3 IL34 IL36A IL36B IL36G IL36RN IL37 IL4 IL5 IL6 IL7 IL9 IMPG1 IMPG2 INHA INHBA INHBB INHBC INHBE INS INS-IGF2 INSL3 INSL5 INSL6 ISM1 ISM2 ITIH1 ITIH2 ITIH3 ITIH4 ITIH5 ITIH6 ITLN1 ITLN2 KAL1 KAZALD1 KCP KERA KITLG KNG1 KY LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LEFTY1 LEFTY2 LEP LGALS1 LGALS12 LGALS13 LGALS14 LGALS16 LGALS2 LGALS3 LGALS4 LGALS7 LGALS8 LGALS9 LGALS9B LGALS9C LGALSL LGI1 LGI2 LGI3 LGI4 LIF LMAN1 LMAN1L LOX LOXL1 LOXL2 LOXL3 LOXL4 LPA LRG1 LTA LTB LTBP1 LTBP2 LTBP3 LTBP4 LUM MASP1 MASP2 MATN1 MATN2 MATN3 MATN4 MBL2 MDK MEGF10 MEGF11 MEGF6 MEGF8 MEGF9 MEP1A MEP1B MEPE MFAP1 MFAP2 MFAP3 MFAP4 MFAP5 MFGE8 MGP MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 MMRN1 MMRN2 MST1 MST1L MSTN MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC22 MUC3A MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUCL1 MXRA5 NCAN NDNF NELL1 NELL2 NGF NGLY1 NID1 NID2 NODAL NOV NPNT NRG1 NRG2 NRG3 NRG4 NRTN NTF3 NTF4 NTN1 NTN3 NTN4 NTN5 NTNG1 NTNG2 NYX OGFOD1 OGFOD2 OGN OIT3 OMD OPTC OSM OTOG OTOL1 OVGP1 P3H1 P3H2 P3H3 P4HA1 P4HA2 P4HA3 P4HTM PAMR1 PAPLN PAPPA PAPPA2 PARM1 PCOLCE PCOLCE2 PCSK5 PCSK6 PDGFA PDGFB PDGFC PDGFD PF4 PF4V1 PGF PI3 PIK3IP1 PLAT PLAU PLG PLOD1 PLOD2 PLOD3 PLXDC1 PLXDC2 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB2 PLXNB3 PLXNC1 PLXND1 PODN PODNL1 POMZP3 POSTN PPBP PRELP PRG2 PRG3 PRG4 PRL PROL1 PRSS1 PRSS12 PRSS2 PRSS3 PSPN PTN PXDN PXDNL PZP REG1A REG1B REG3A REG3G REG4 RELN RPTN RSPO1 RSPO2 RSPO3 RSPO4 S100A1 S100A10 S100A11 S100A12 S100A13 S100A14 S100A16 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7 S100A7A S100A7L2 S100A8 S100A9 S100B S100G S100P S100Z SBSPON SCUBE1 SCUBE2 SCUBE3 SDC1 SDC2 SDC3 SDC4 SEMA3A SEMA3B SEMA3C SEMA3D SEMA3E SEMA3F SEMA3G SEMA4A SEMA4B SEMA4C SEMA4D SEMA4F SEMA4G SEMA5A SEMA5B SEMA6A SEMA6B SEMA6C SEMA6D SEMA7A SERPINA1 SERPINA10 SERPINA11 SERPINA12 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA9 SERPINB1 SERPINB10 SERPINB11 SERPINB12 SERPINB13 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE3 SERPINF1 SERPINF2 SERPING1 SERPINH1 SERPINI1 SERPINI2 SFRP1 SFRP2 SFRP4 SFRP5 SFTA2 SFTA3 SFTPA1 SFTPA2 SFTPB SFTPC SFTPD SHH SLIT1 SLIT2 SLIT3 SLPI SMOC1 SMOC2 SNED1 SPAM1 SPARC SPARCL1 SPOCK1 SPOCK2 SPOCK3 SPON1 SPON2 SPP1 SRGN SRPX SRPX2 SSPO ST14 SULF1 SULF2 SVEP1 TCHH TCHHL1 TDGF1 TECTA TECTB TGFA TGFB1 TGFB2 TGFB3 TGFBI TGM1 TGM2 TGM3 TGM4 TGM5 TGM6 TGM7 THBS1 THBS2 THBS3 THBS4 THPO THSD4 TIMP1 TIMP2 TIMP3 TIMP4 TINAG TINAGL1 TLL1 TLL2 TMPRSS15 TNC TNF TNFAIP6 TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 TNN TNR TNXB TPO TSKU TSPEAR USH2A VCAN VEGFA VEGFB VEGFC VIT VTN VWA1 VWA2 VWA3A VWA3B VWA5A VWA5B1 VWA5B2 VWA7 VWA9 VWC2 VWC2L VWCE VWDE VWF WFIKKN1 WFIKKN2 WIF1 WISP1 WISP2 WISP3 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 ZFP91 ZP1 ZP2 ZP3 ZP4 ZPLD1 +NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors A2M A2ML1 ADAM10 ADAM11 ADAM12 ADAM15 ADAM17 ADAM18 ADAM19 ADAM2 ADAM20 ADAM21 ADAM22 ADAM23 ADAM28 ADAM29 ADAM30 ADAM32 ADAM33 ADAM7 ADAM8 ADAM9 ADAMDEC1 ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 AGT AMBP AMH ANGPT1 ANGPT2 ANGPT4 ANGPTL1 ANGPTL2 ANGPTL3 ANGPTL4 ANGPTL5 ANGPTL6 ANGPTL7 ANXA1 ANXA10 ANXA11 ANXA13 ANXA2 ANXA3 ANXA4 ANXA5 ANXA6 ANXA7 ANXA8 ANXA8L1 ANXA9 AREG ARTN ASTL BDNF BMP1 BMP10 BMP15 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B BRINP2 BRINP3 BTC C17orf58 C1QA C1QB C1QC C1QL1 C1QL2 C1QL3 C1QL4 C1QTNF1 C1QTNF2 C1QTNF3 C1QTNF4 C1QTNF5 C1QTNF6 C1QTNF7 C1QTNF8 C1QTNF9 C1QTNF9B CBLN1 CBLN2 CBLN3 CBLN4 CCBE1 CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CD109 CD209 CELA1 CELA2A CELA2B CELA3A CELA3B CFC1 CFC1B CHRD CHRDL1 CHRDL2 CLC CLCF1 CLEC10A CLEC11A CLEC12A CLEC12B CLEC14A CLEC17A CLEC18A CLEC18B CLEC18C CLEC19A CLEC1A CLEC1B CLEC2A CLEC2B CLEC2D CLEC2L CLEC3A CLEC3B CLEC4A CLEC4C CLEC4D CLEC4E CLEC4F CLEC4G CLEC4M CLEC5A CLEC6A CLEC7A CLEC9A CNTF COLEC10 COLEC11 COLEC12 CPAMD8 CPN2 CRHBP CRLF1 CRLF3 CRNN CSF1 CSF2 CSF3 CSH1 CSH2 CSHL1 CSPG4 CSPG5 CST1 CST11 CST2 CST3 CST4 CST5 CST6 CST7 CST8 CST9 CST9L CSTA CSTB CSTL1 CTF1 CTSA CTSB CTSC CTSD CTSE CTSF CTSG CTSH CTSK CTSL CTSO CTSS CTSV CTSW CTSZ CX3CL1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 DHH EBI3 EDA EGF EGFL6 EGFL7 EGFL8 EGLN1 EGLN2 EGLN3 ELANE ELFN1 ELFN2 EMCN EPGN EPO EREG F10 F12 F13A1 F13B F2 F7 F9 FAM20A FAM20B FAM20C FASLG FCN1 FCN2 FCN3 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FIGF FLG FLG2 FLT3LG FREM1 FREM2 FREM3 FRZB FST FSTL1 FSTL3 GDF1 GDF10 GDF11 GDF15 GDF2 GDF3 GDF5 GDF6 GDF7 GDF9 GDNF GH1 GH2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GREM1 GRIFIN HABP2 HBEGF HCFC1 HCFC2 HGF HGFAC HHIP HMSD HPSE HPSE2 HPX HRG HRNR HTRA1 HTRA3 HTRA4 HYAL1 HYAL2 HYAL3 HYAL4 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNE IFNG IFNK IFNW1 IGF1 IGF2 IHH IL10 IL11 IL12A IL12B IL13 IL15 IL16 IL17A IL17B IL17C IL17D IL17F IL18 IL19 IL1A IL1B IL1F10 IL1RN IL2 IL20 IL22 IL23A IL24 IL25 IL26 IL3 IL34 IL36A IL36B IL36G IL36RN IL37 IL4 IL5 IL6 IL7 IL9 INHA INHBA INHBB INHBC INHBE INS INS-IGF2 INSL3 INSL5 INSL6 ISM1 ISM2 ITIH1 ITIH2 ITIH3 ITIH4 ITIH5 ITIH6 ITLN1 ITLN2 KAZALD1 KITLG KNG1 KY LEFTY1 LEFTY2 LEP LGALS1 LGALS12 LGALS13 LGALS14 LGALS16 LGALS2 LGALS3 LGALS4 LGALS7 LGALS8 LGALS9 LGALS9B LGALS9C LGALSL LIF LMAN1 LMAN1L LOX LOXL1 LOXL2 LOXL3 LOXL4 LPA LTA LTB MASP1 MASP2 MBL2 MDK MEGF10 MEGF11 MEGF6 MEGF8 MEGF9 MEP1A MEP1B MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 MST1 MST1L MSTN MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC22 MUC3A MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUCL1 NGF NGLY1 NODAL NRG1 NRG2 NRG3 NRG4 NRTN NTF3 NTF4 OGFOD1 OGFOD2 OSM OVGP1 P3H1 P3H2 P3H3 P4HA1 P4HA2 P4HA3 P4HTM PAMR1 PAPPA PAPPA2 PARM1 PCSK5 PCSK6 PDGFA PDGFB PDGFC PDGFD PF4 PF4V1 PGF PI3 PIK3IP1 PLAT PLAU PLG PLOD1 PLOD2 PLOD3 PLXDC1 PLXDC2 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB2 PLXNB3 PLXNC1 PLXND1 PPBP PRL PROL1 PRSS1 PRSS12 PRSS2 PRSS3 PSPN PTN PZP REG1A REG1B REG3A REG3G REG4 RPTN S100A1 S100A10 S100A11 S100A12 S100A13 S100A14 S100A16 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7 S100A7A S100A7L2 S100A8 S100A9 S100B S100G S100P S100Z SCUBE1 SCUBE2 SCUBE3 SDC1 SDC2 SDC3 SDC4 SEMA3A SEMA3B SEMA3C SEMA3D SEMA3E SEMA3F SEMA3G SEMA4A SEMA4B SEMA4C SEMA4D SEMA4F SEMA4G SEMA5A SEMA5B SEMA6A SEMA6B SEMA6C SEMA6D SEMA7A SERPINA1 SERPINA10 SERPINA11 SERPINA12 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA9 SERPINB1 SERPINB10 SERPINB11 SERPINB12 SERPINB13 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE3 SERPINF1 SERPINF2 SERPING1 SERPINH1 SERPINI1 SERPINI2 SFRP1 SFRP2 SFRP4 SFRP5 SFTA2 SFTA3 SFTPA1 SFTPA2 SFTPB SFTPC SFTPD SHH SLPI SPAM1 ST14 SULF1 SULF2 TCHH TCHHL1 TDGF1 TGFA TGFB1 TGFB2 TGFB3 TGM1 TGM2 TGM3 TGM4 TGM5 TGM6 TGM7 THPO TIMP1 TIMP2 TIMP3 TIMP4 TLL1 TLL2 TMPRSS15 TNF TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 TPO VEGFA VEGFB VEGFC VWC2 VWC2L WFIKKN1 WFIKKN2 WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 ZFP91 +NABA_PROTEOGLYCANS Genes encoding proteoglycans ACAN ASPN BCAN BGN CHAD CHADL DCN EPYC ESM1 FMOD HAPLN1 HAPLN2 HAPLN3 HAPLN4 HSPG2 IMPG1 IMPG2 KERA LUM NCAN NYX OGN OMD OPTC PODN PODNL1 PRELP PRG2 PRG3 PRG4 SPOCK1 SPOCK2 SPOCK3 SRGN VCAN +NABA_SECRETED_FACTORS Genes encoding secreted soluble factors AMH ANGPT1 ANGPT2 ANGPT4 ANGPTL1 ANGPTL2 ANGPTL3 ANGPTL4 ANGPTL5 ANGPTL6 ANGPTL7 AREG ARTN BDNF BMP10 BMP15 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B BRINP2 BRINP3 BTC C1QTNF9B CBLN1 CBLN2 CBLN3 CBLN4 CCBE1 CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CFC1 CFC1B CHRD CHRDL1 CHRDL2 CLCF1 CNTF CRHBP CRLF1 CRLF3 CRNN CSF1 CSF2 CSF3 CSH1 CSH2 CSHL1 CTF1 CX3CL1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 DHH EBI3 EDA EGF EGFL6 EGFL7 EGFL8 EPGN EPO EREG FASLG FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FIGF FLG FLG2 FLT3LG FRZB FST FSTL1 FSTL3 GDF1 GDF10 GDF11 GDF15 GDF2 GDF3 GDF5 GDF6 GDF7 GDF9 GDNF GH1 GH2 HBEGF HCFC1 HCFC2 HGF HGFAC HHIP HRNR IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNE IFNG IFNK IFNW1 IGF1 IGF2 IHH IL10 IL11 IL12A IL12B IL13 IL15 IL16 IL17A IL17B IL17C IL17D IL17F IL18 IL19 IL1A IL1B IL1F10 IL1RN IL2 IL20 IL22 IL23A IL24 IL25 IL26 IL3 IL34 IL36A IL36B IL36G IL36RN IL37 IL4 IL5 IL6 IL7 IL9 INHA INHBA INHBB INHBC INHBE INS INS-IGF2 INSL3 INSL5 INSL6 ISM1 ISM2 KITLG LEFTY1 LEFTY2 LEP LIF LTA LTB MDK MEGF10 MEGF11 MEGF6 MEGF8 MEGF9 MST1 MST1L MSTN NGF NODAL NRG1 NRG2 NRG3 NRG4 NRTN NTF3 NTF4 OSM PDGFA PDGFB PDGFC PDGFD PF4 PF4V1 PGF PIK3IP1 PPBP PRL PSPN PTN RPTN S100A1 S100A10 S100A11 S100A12 S100A13 S100A14 S100A16 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7 S100A7A S100A7L2 S100A8 S100A9 S100B S100G S100P S100Z SCUBE1 SCUBE2 SCUBE3 SFRP1 SFRP2 SFRP4 SFRP5 SHH TCHH TCHHL1 TDGF1 TGFA TGFB1 TGFB2 TGFB3 THPO TNF TNFSF10 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF4 TNFSF8 TNFSF9 TPO VEGFA VEGFB VEGFC VWC2 VWC2L WFIKKN1 WFIKKN2 WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 ZFP91 +PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling AKT1 CASP7 CD9 CDH1 COL17A1 EGF EGFR ERBB2 ERBB3 GRB2 HRAS IL1A ITGA6 ITGB1 ITGB4 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 MET MST1 MST1R PIK3CA PIK3R1 PMP22 PRKCA RAC1 RPS6KB1 RXRA RXRB RXRG SFN SHC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly ABL1 ADAM10 ARF6 BDNF CABLES1 CASP3 CBLL1 CDC42 CDH1 CDH2 CREBBP CTNNA1 CTNNB1 CTNND1 DNM2 DSP EGF EGFR FYN GDNF GFRA1 GNA12 GNA13 HGS HRAS IGF1R IGF2 IQGAP1 JUP MEP1B MET MMP3 MMP7 NME1 NTRK2 PTPN1 PTPN6 RAB5A RAB7A RAC1 RET RIN2 ROBO1 SLIT1 SNX1 SRC TIAM1 ZBTB33 +PID_ALK1_PATHWAY ALK1 signaling events ACVR1 ACVR2A ACVR2B ACVRL1 ARRB2 BMPR2 CAV1 CSNK2B ENG FKBP1A GDF2 ID1 INHBA MAPK1 MAPK3 PPP1CA SMAD1 SMAD4 SMAD5 SMAD7 SMAD9 TGFB1 TGFB3 TGFBR1 TGFBR2 TLX2 +PID_ALK2_PATHWAY ALK2 signaling events ACVR1 AMH AMHR2 BMP7 BMPR2 FKBP1A SMAD1 SMAD4 SMAD5 SMAD9 TLX2 +PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling BAD BLK CSNK2A1 FGR FKBP1A FYN GRK5 HCK KLK6 LCK LYN MAOB MAPK1 MAPK3 PARK2 PARK7 PLCB2 PLD1 PLD2 PPP2R5D PRKCD PTK2B SLC6A3 SNCA SNCAIP SRC STUB1 SYK TH TOR1A UBE2L3 UCHL1 YES1 +PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling AGER AKT1 APOB BLK CTGF FGR FYN HCK HMGB1 ICAM1 IL6 ITGAM ITGB2 JAM2 JAM3 LCK LPA LRP1 LYN MMP2 MMP9 MST1 MST1R MYH2 NFKB1 PLAT PLAU PLAUR PLG PRKCZ RAP1A RAP1B RHOA ROCK1 SELP SELPLG SRC THY1 TLN1 TNF YES1 +PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling AGTR1 AKT1 ANGPT1 ANGPT2 ANGPT4 BMX CDKN1A CRK DOK2 ELF1 ELF2 ELK1 ETS1 F2 FES FGF2 FN1 FOXO1 FYN GRB14 GRB2 GRB7 ITGA5 ITGB1 MAPK1 MAPK14 MAPK3 MAPK8 MMP2 NCK1 NFKB1 NOS3 PAK1 PIK3CA PIK3R1 PLD2 PLG PTK2 PTPN11 PXN RAC1 RASA1 RELA RPS6KB1 SHC1 STAT5A STAT5B TEK TNF TNIP2 +PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin ANTXR1 ANTXR2 CASP1 IL18 IL1B MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK1 MAPK3 NLRP1 PGR TNF VCAM1 +PID_AP1_PATHWAY AP-1 transcription factor network ACTA1 AGT ATF2 ATF3 BAG1 BCL2L11 CBFB CCL2 CCND1 CDK1 CDKN1B CDKN2A COL1A2 COPS5 CREB1 CRTC1 CSF2 CTNNB1 CYR61 DMP1 DMTF1 DUSP1 EDN1 EGR1 ELF1 EP300 ESR1 ETS1 FABP4 FOS FOSB FOSL1 FOSL2 GATA2 GJA1 HIF1A HLA-A IFNG IL10 IL2 IL4 IL5 IL6 IL8 JUN JUNB JUND MAF MAFG MMP1 MMP9 MT2A MYB MYC NFATC1 NFATC2 NFATC3 NPPA NR3C1 NTS PENK PLAU PTEN SP1 TCF7L2 TGFB1 TH TIMP1 TP53 TRIP6 +PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling AKT1 AR CDC42 CREB1 FOS GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNG2 GNRH1 HRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PELP1 PIK3CA PIK3R1 PLCB1 PLCB2 PLCB3 PLCG1 PLCG2 PTK2 RAC1 RAF1 SHBG SRC +PID_AR_PATHWAY Coregulation of Androgen receptor activity AKT1 APPL1 AR BRCA1 CARM1 CASP8 CCND1 CCND3 CDK11B CDK6 CDKN2A CMTM2 CTDSP1 CTDSP2 CTNNB1 FHL2 FKBP4 GSN HIP1 HNRNPA1 KDM1A KDM3A KDM4C KLK2 KLK3 LATS2 MAK MED1 NCOA2 NCOA4 NCOA6 NKX3-1 NRIP1 PA2G4 PATZ1 PAWR PELP1 PIAS1 PIAS3 PIAS4 PRDX1 PRKDC PTK2B RANBP9 RPS6KA3 SNURF SRF SVIL TCF4 TGFB1I1 TGIF1 TMF1 TMPRSS2 UBA3 UBE2I UBE3A VAV3 XRCC5 XRCC6 ZMIZ1 ZNF318 +PID_AR_TF_PATHWAY Regulation of Androgen receptor activity APPBP2 AR CARM1 CEBPA CREBBP DNAJA1 EGR1 EHMT2 EP300 FOXO1 GATA2 GNB2L1 GSK3B HDAC1 HDAC7 HOXB13 HSP90AA1 JUN KAT2B KAT5 KAT7 KLK2 KLK3 MAP2K4 MAP2K6 MAPK14 MAPK8 MDM2 NCOA1 NCOA2 NR0B1 NR2C1 NR2C2 NR3C1 PDE9A PKN1 POU2F1 RCHY1 REL RXRA RXRB RXRG SENP1 SIRT1 SMARCA2 SMARCC1 SMARCE1 SPDEF SRC SRY TMPRSS2 TRIM24 ZMIZ2 +PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway ARF1 ARF6 KALRN MAPK1 MAPK3 NME1 PIP5K1A PLAUR PLD1 PLD2 RAB11A RAB11FIP3 RAC1 RHOA TIAM1 +PID_ARF6_PATHWAY Arf6 signaling events ACAP1 ACAP2 ADAP1 ADRB2 AGTR1 ARAP2 ARF6 ARRB1 ARRB2 CYTH2 CYTH3 EFNA1 EGF EGFR EPHA2 FBXO8 GIT1 GNA11 GNA14 GNA15 GNAQ GULP1 HGF IPCEF1 IQSEC1 ITGA2B ITGB3 KIF13B LHCGR MET NCK1 PXN SRC TSHR USP6 +PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events ACAP1 ADRB2 AGTR1 ARF6 ASAP2 AVPR2 BIN1 CDH1 CLTC CPE CTNNA1 CTNNB1 CTNND1 DNM2 EDNRB EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 IL2RA INS ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 KLC1 MAPK8IP3 NME1 PIP5K1C PLD1 PLD2 RALA SCAMP2 SLC2A4 SPAG9 TSHR VAMP3 +PID_ARF_3PATHWAY Arf1 pathway AP2A1 AP2M1 ARF1 ARFGAP1 ARFIP2 ASAP1 CD4 CLTA CLTB COPA CYTH2 GBF1 GGA3 GOSR2 KDELR1 PIP5K1A PLD2 RAC1 USO1 +PID_ATF2_PATHWAY ATF-2 transcription factor network ACHE ARG1 ATF2 ATF3 BCL2 BCL2L1 BRCA1 CBFB CCNA2 CCND1 CDK4 COL24A1 CREB1 CSRP2 CUL3 DDIT3 DUSP1 DUSP10 DUSP5 DUSP8 EP300 ESR1 FOS GADD45A H2AFY HBG2 HES1 HRK IFNG IL23A IL6 IL8 INS JDP2 JUN JUNB JUND KAT5 MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MMP2 NF1 NOS2 PDGFRA PLAU POU2F1 PPARGC1A PRKCA RB1 RUVBL2 SELE SERPINB5 SOCS3 TGFB2 TH +PID_ATM_PATHWAY ATM pathway ABL1 ATM BID BLM BRCA1 CDC25A CDC25C CHEK2 CTBP1 DCLRE1C FAM175A FANCD2 H2AFX KAT5 MDC1 MDM2 MRE11A NBN RAD17 RAD50 RAD9A RBBP8 RFWD2 RNF8 SMC1A SMC3 TERF2 TOP3A TP53BP1 TRIM28 UBE2N UIMC1 XRCC4 YWHAB +PID_ATR_PATHWAY ATR signaling pathway ATR ATRIP BRCA2 CCNA2 CDC25A CDC25C CDC6 CDK2 CEP164 CHEK1 CLSPN FANCD2 FBXW11 HUS1 MCM2 MCM7 MDM2 NBN PLK1 PPP2CA PPP2R1A PPP2R2B RAD1 RAD17 RAD51 RAD9A RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 SMARCAL1 SSPO TIMELESS TIPIN TOPBP1 YWHAB YWHAZ +PID_AURORA_A_PATHWAY Aurora A signaling AKT1 ARHGEF7 AURKA AURKAIP1 AURKB BIRC5 BRCA1 CDC25B CENPA CKAP5 CPEB1 DLGAP5 FZR1 GADD45A GIT1 GSK3B JUB MDM2 NDEL1 NFKBIA OAZ1 PAK1 PPP2R5D PRKACA RAN RASA1 TACC1 TACC3 TDRD7 TP53 TPX2 +PID_AURORA_B_PATHWAY Aurora B signaling AURKA AURKB AURKC BIRC5 BUB1 CBX5 CDCA8 CENPA CUL3 DES EVI5 INCENP KIF20A KIF23 KIF2C KLHL13 KLHL9 MYLK NCAPD2 NCAPG NCAPH NCL NDC80 NPM1 NSUN2 PEBP1 PPP1CC PPP2R5D PSMA3 RACGAP1 RASA1 RHOA SEPT1 SGOL1 SMC2 SMC4 STMN1 TACC1 VIM +PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis AKT1 ANGPTL3 BCAR1 CASP8 CBL CDKN1B COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 CSF1 CSF1R EDIL3 F11R FGF2 FN1 GPR124 HSP90AA1 IGF1 IGF1R ILK IRS1 ITGAV ITGB3 KDR MAPK1 MAPK3 MFGE8 PI4KA PI4KB PIK3C2A PIK3CA PIK3R1 PTK2 PTK2B PTPN11 PXN RAC1 RHOA ROCK1 RPS6KB1 SDC1 SPP1 SRC TGFBR2 TLN1 VAV3 VCL VEGFA VTN +PID_AVB3_OPN_PATHWAY Osteopontin-mediated events BCAR1 CD44 CDC42 CHUK FOS GSN ILK ITGAV ITGB3 JUN MAP3K1 MAP3K14 MAPK1 MAPK3 MAPK8 MMP2 MMP9 NFKB1 NFKBIA PIK3CA PIK3R1 PIP5K1A PLAU PTK2B RAC1 RELA RHOA ROCK2 SPP1 SYK VAV3 +PID_BARD1_PATHWAY BARD1 signaling events ATM ATR BARD1 BRCA1 CCNE1 CDK2 CSTF1 EWSR1 FANCA FANCC FANCD2 FANCE FANCF FANCG FANCL MRE11A NBN NPM1 PCNA PRKDC RAD50 RAD51 RBBP8 TOPBP1 TP53 UBE2D3 UBE2L3 XRCC5 XRCC6 +PID_BCR_5PATHWAY BCR signaling pathway AKT1 BCL10 BCL2A1 BLNK BTK CAMK2G CARD11 CD19 CD22 CD72 CD79A CD79B CHUK CSK CSNK2A1 DAPP1 DOK1 ELK1 ETS1 FCGR2B FOS GRB2 HRAS IBTK IKBKB IKBKG INPP5D JUN LYN MALT1 MAP2K1 MAP3K1 MAP3K7 MAP4K1 MAPK1 MAPK14 MAPK3 MAPK8 NFATC1 NFKB1 NFKBIA NFKBIB PAG1 PDPK1 PIK3AP1 PIK3CA PIK3R1 PLCG2 POU2F2 PPP3CA PPP3CB PPP3CC PTEN PTPN6 PTPRC RAC1 RAF1 RASA1 RELA SH3BP5 SHC1 SOS1 SYK TRAF6 VAV2 +PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin APC AXIN1 AXIN2 CSNK1A1 CSNK1D CSNK1E CTNNB1 CUL1 DVL1 DVL2 DVL3 FZD5 GSK3A GSK3B LRP6 SKP1 SSPO WNT3A +PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription ADCY7 AES APC AR AXIN2 BCL9 CACNA1G CAMK4 CBY1 CCND1 CCND2 CDH1 CDKN2A CDX1 CDX4 CHD8 COX2 CTBP1 CTNNB1 CTNNBIP1 CUL1 CYR61 DKK1 DKK4 DVL3 EP300 FGF4 HBP1 HDAC1 HDAC2 ID2 IGF2BP1 IL8 INCENP JUN KCNIP4 KLF4 KRT1 LEF1 MDFIC MED12 MITF MMP2 MMP9 MYC MYF5 MYOG NCOA2 NEUROG1 PITX2 RUVBL2 SALL4 SFN SKP1 SMARCA4 SNAI2 SP5 SSPO T TBL1X TBL1XR1 TCF4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE4 TNIK TRRAP VCAN XPO1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZCCHC12 +PID_BMP_PATHWAY BMP receptor signaling AHSG BAMBI BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B BMPR2 CER1 CHRD CHRDL1 CTDSP1 CTDSP2 CTDSPL FST GREM1 GSK3B HFE2 MAP3K7 MAPK1 NOG NUP214 PPM1A PPP1CA PPP1R15A RGMA RGMB SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 SOSTDC1 TAB1 TAB2 XIAP ZFYVE16 +PID_CASPASE_PATHWAY Caspase cascade in apoptosis ACTA1 APAF1 APP ARHGDIB BAX BCL2 BID BIRC2 BIRC3 CASP1 CASP10 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CFL2 CRADD CYCS DFFA DFFB DIABLO GAS2 GSN GZMB KRT18 LIMK1 LMNA LMNB1 LMNB2 MADD MAP3K1 NUMA1 PARP1 PIDD PRF1 PTK2 RIPK1 SATB1 SLK SPTAN1 SREBF1 TFAP2A TNF TNFRSF1A TOP1 TRADD TRAF2 VIM XIAP +PID_CD40_PATHWAY CD40/CD40L signaling AKT1 BCL2L1 BIRC2 BIRC3 C4BPA CBLB CD40 CD40LG FCAMR IL4 JAK3 JUN MAP2K4 MAP3K1 MAP3K14 MAPK10 MAPK11 MAPK14 MAPK8 MAPK9 MYC NFKB1 NFKBIA RELA STAT5A TDP2 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF6 +PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells B2M BRAF CD247 CD3D CD3E CD3G CD8A CD8B EGR1 EGR4 ELK1 EOMES FASLG FOS FOSL1 GZMB HLA-A HRAS IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNG IL2 IL2RA IL2RB IL2RG JUN JUNB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK8 MAPK9 NFATC1 NFATC2 NFATC3 NRAS PPP3CA PPP3CB PPP3R1 PRF1 PRKCA PRKCB PRKCE PRKCQ PTPN7 RAF1 STAT4 TNF TNFRSF18 TNFRSF4 TNFRSF9 +PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells AKT1 B2M BCL10 CARD11 CBL CD247 CD28 CD3D CD3E CD3G CD80 CD86 CD8A CD8B CHUK CSK FYN GRAP2 GRB2 HLA-A HRAS IKBKB IKBKG KRAS LAT LCK LCP2 MALT1 MAP3K14 MAP3K8 NRAS ORAI1 PAG1 PDPK1 PLCG1 PRF1 PRKCA PRKCB PRKCE PRKCQ PTPN6 PTPRC RAP1A RASGRP1 RASGRP2 RASSF5 SHC1 SOS1 STIM1 TRAF6 TRPV6 VAV1 ZAP70 +PID_CDC42_PATHWAY CDC42 signaling events ACTR2 ACTR3 APC ARHGDIA ARHGEF6 ARHGEF7 ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF2 BAIAP2 BCAR1 BRAF CBL CDC42 CDC42BPA CDH1 CFL1 CTNNA1 CTNNB1 DIAPH3 DLG1 ENAH EPS8 EXOC7 F2RL2 GSK3B HES5 HRAS IQGAP1 IQGAP3 JUN LIMK1 LIMK2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K11 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 MTOR MYL2 PAK1 PAK2 PAK4 PARD6A PAX6 PIK3CA PIK3R1 PLD1 PRKCE PRKCZ RAC1 RAF1 RASGRF1 RPS6KB1 SEPT2 SRC TIAM1 TNK2 VAV2 WASL YES1 +PID_CDC42_REG_PATHWAY Regulation of CDC42 activity APC ARHGAP1 ARHGAP17 ARHGDIA ARHGEF25 ARHGEF6 ARHGEF7 ARHGEF9 BCAR3 CDC42 DNMBP DOCK10 DOCK11 DOCK6 DOCK9 FARP2 FGD1 GIT1 ITSN1 ITSN2 MCF2 MCF2L NGEF NME1 PLCG1 RACGAP1 RALBP1 SPATA13 VAV2 VAV3 +PID_CERAMIDE_PATHWAY Ceramide signaling pathway AIFM1 AKT1 ASAH1 BAD BAG4 BAX BCL2 BID BIRC3 CASP8 CRADD CTSD CYCS EGF EIF2A EIF2AK2 FADD IGF1 KSR1 MADD MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAP4K4 MAPK1 MAPK3 MAPK8 MYC NFKB1 NFKBIA NSMAF PAWR PDGFA PRKCD PRKCZ PRKRA RAF1 RB1 RELA RIPK1 SMPD1 SMPD3 SPHK2 TNF TNFRSF1A TRADD TRAF2 +PID_CIRCADIAN_PATHWAY Circadian rhythm pathway ARNTL ATR BHLHE40 CHEK1 CLOCK CRY1 CRY2 CSNK1E DEC1 NONO NPAS2 NR1D1 PER1 PER2 TIMELESS WDR5 +PID_CMYB_PATHWAY C-MYB transcription factor network ADA ADORA2B ANPEP ATP2B1 BCL2 BIRC3 CA1 CASP6 CBX4 CCNA1 CCNB1 CCND1 CD34 CD4 CDK6 CDKN1A CDKN1B CDKN2A CEBPA CEBPB CEBPD CLTA COL1A2 COPA CREBBP CSF1R ELANE EP300 ETS1 ETS2 GATA1 GATA3 GSTM1 H2AFZ HES1 HIPK2 HRAS HSPA8 IQGAP1 KIT KITLG KRAS LECT2 LEF1 LYZ MAD1L1 MAF MAP3K7 MAT2A MCM4 MPO MYB MYC MYF6 MYOD1 NCOR1 NLK NRAS PAX5 PIAS3 PIM1 PPID PPP3CA PRTN3 PTCRA PTGS2 RAG2 SIN3A SKI SLC25A3 SMARCA2 SND1 SP1 SPI1 TAB1 TAB2 TFEC TOM1 TRIM28 UBE2I WNT1 YEATS4 ZFHX3 ZFPM1 +PID_CONE_PATHWAY Visual signal transduction: Cones ARR3 CNGA3 CNGB3 GNAT2 GNB3 GNB5 GNGT2 GRK1 GRK7 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F LRAT PDE6C PDE6H RDH12 RDH5 RGS9 RGS9BP RPE65 SLC24A2 +PID_CXCR3_PATHWAY CXCR3-mediated signaling events AKT1 ARRB1 CCL11 CXCL10 CXCL11 CXCL13 CXCL9 CXCR3 DNM1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNG2 HRAS ITGAL ITGB2 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK11 MAPK14 MAPK3 MAPKAP1 MLST8 MTOR NRAS PDPK1 PF4 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAF1 RICTOR SRC +PID_CXCR4_PATHWAY CXCR4-mediated signaling events ADRBK1 AKT1 ARR3 ARRB2 BAD BCAR1 BLK CD247 CD3D CD3E CD3G CD4 CDC42 CFL1 CRK CSK CXCL12 CXCR4 DNM1 FGR FOXO1 FYN GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2L1 GNG2 GRK6 HCK HGS HLA-DRA HLA-DRB1 INPP5D ITCH ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 JAK2 LCK LIMK1 LYN MAPKAP1 MLST8 MMP9 MTOR PAG1 PAK1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 PRKCZ PTEN PTK2 PTK2B PTPN11 PTPN6 PTPRC PXN RAC1 RALB RAP1B RGS1 RHOA RHOB RHOC RICTOR SRC SSH1 STAT1 STAT2 STAT3 STAT5A STAT5B UBQLN1 VAV1 VPS4A VPS4B YES1 +PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms ADA ADRM1 ATM AXL BDKRB2 BRCA2 CCNB2 CDKN2A CEBPD COL5A1 DLX5 DLX6 FASN FBXW7 FOSL2 GNB2L1 GPX2 GSK3B HBP1 HELLS HES1 IGFBP3 IL1A ITCH ITGA3 KRT14 KRT5 MDM2 MRE11A NOTCH1 NRG1 PERP POU2F2 PPP2R5A RAB38 RRAD RUNX1 SEC14L2 SFN STXBP4 T TCF7L1 TOP2A TP63 VDR WWP1 YAP1 +PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining APLF APTX CSNK2A1 CSNK2A2 CSNK2B DCLRE1C DNTT LIG4 NHEJ1 PNKP POLL POLM PRKDC XRCC4 XRCC5 XRCC6 +PID_E2F_PATHWAY E2F transcription factor network APAF1 ATM BRCA1 CASP7 CBX5 CCNA2 CCND3 CCNE1 CCNE2 CDC25A CDC6 CDK1 CDK2 CDKN1A CDKN1B CDKN2A CDKN2C CEBPA CES1 CES1P1 CES2 CES3 CES4A CES5A CREBBP DHFR E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 E2F7 EP300 HBP1 HDAC1 HIC1 KAT2A KAT2B MCL1 MCM3 MYBL2 MYC ORC1 PLAU POLA1 PRMT5 RANBP1 RB1 RBBP4 RBBP8 RBL1 RBL2 RRM1 RRM2 RYBP SERPINE1 SIRT1 SMARCA2 SP1 SULT2A1 TFDP1 TFDP2 TFE3 TK1 TOPBP1 TP73 TRIM28 TRRAP TYMS UXT WASF1 XRCC1 YY1 +PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes AKT1 AKT2 CASR CDH1 CTNNA1 CTNNB1 CTNND1 EGFR FMN1 FYN JUB JUP PIK3CA PIK3R1 PIP5K1A PLCG1 RAC1 RHOA SRC VASP ZYX +PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction ABI1 AKT1 AP1M1 ARF6 CCND1 CDC42 CDH1 CRK CSNK2A1 CSNK2A2 CSNK2B CTNNA1 CTNNB1 CTNND1 CTTN CYFIP2 DLG1 ENAH IQGAP1 ITGAE ITGB7 JUP KLHL20 MLLT4 NCKAP1 NME1 PIK3CA PIK3R1 PIP5K1C RAC1 RAP1A RAP1B RAPGEF1 RHOA SRC TIAM1 TJP1 VAV2 WASF2 +PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction ABI1 ACTN1 AQP3 AQP5 ARF6 CAMSAP3 CDH1 CTNNA1 CTNNB1 CTNND1 CYFIP2 DIAPH1 EFNA1 EGF EGFR ENAH EPHA2 EXOC3 EXOC4 GIT1 HGF IGF1 IGF1R KIFC3 LIMA1 LPP MET MGAT3 MLLT4 MYL2 MYO6 NCK1 NCKAP1 PIP5K1C PLEKHA7 PVRL2 RHOA ROCK1 STX4 VASP VCL ZYX +PID_ENDOTHELIN_PATHWAY Endothelins ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 BCAR1 CDC42 COL1A2 COL3A1 CRK CYSLTR1 CYSLTR2 EDN1 EDN2 EDN3 EDNRA EDNRB FOS GNA11 GNA12 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAZ HRAS JAK2 JUN MAP2K1 MAP2K2 MAPK1 MAPK14 MAPK3 MAPK8 MMP1 PLA2G4A PLCB1 PLCB2 PLCB3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PTK2B RAC1 RAF1 RHOA SLC9A1 SLC9A3 SRC TRPC6 +PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling ACP1 ARHGAP35 BCAR1 CBL EFNA1 EPHA2 GRB2 INPPL1 PAK1 PIK3CA PIK3R1 PTK2 RAC1 RHOA SHC1 SRC TIAM1 VAV2 VAV3 +PID_EPHA_FWDPATHWAY EPHA forward signaling ARHGEF15 BLK CBL CDK5 CRK CRKL EFNA1 EFNA2 EFNA3 EFNA5 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 FGR FYN HCK LCK LYN NGEF PIK3CG PIK3R5 PIK3R6 PLCG1 RHOA ROCK1 SRC VAV2 VAV3 YES1 +PID_EPHB_FWD_PATHWAY EPHB forward signaling CDC42 CRK DNM1 EFNA5 EFNB1 EFNB2 EFNB3 EPHB1 EPHB2 EPHB3 EPHB4 GRB2 GRB7 GRIA1 HRAS ITSN1 KALRN KRAS MAP2K1 MAP4K4 MAPK1 MAPK3 NCK1 NRAS PAK1 PIK3CA PIK3R1 PTK2 PXN RAC1 RAP1A RAP1B RASA1 ROCK1 RRAS SHC1 SRC SYNJ1 TF WASL +PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling BLK CXCR4 DNM1 EFNB1 EFNB2 EPHB1 EPHB2 EPHB4 FGA FGB FGG FGR FYN HCK ITGA2B ITGB3 LCK LYN MAP2K4 MAP3K7 MAPK8 NCK2 PIK3CA PIK3R1 PTPN13 RAC1 RGS3 SRC TIAM1 YES1 +PID_EPO_PATHWAY EPO signaling pathway BCL2 BCL2L1 BTK CBL CRKL EPO EPOR GAB1 GRB2 HRAS INPP5D IRS2 JAK2 LYN MAPK14 MAPK8 NFKB1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RAP1A RAPGEF1 SH2B3 SHC1 SOCS3 SOS1 STAT1 STAT5A STAT5B TEC TRPC6 VAV2 +PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling AKT1 BCAR1 ESR1 ESR2 GNA11 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAZ GNB1 GNG2 GRB2 HBEGF HRAS IGF1 IGF1R KRAS MAPK11 MMP2 MMP9 MSN NOS3 NRAS PELP1 PIK3CA PIK3R1 PLCB1 PLCB2 PLCB3 RHOA ROCK2 SHC1 SOS1 SRC STRN +PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network ABCA3 ANP32A AP1B1 APBB1 ATP5J AXIN2 BRCA1 C3 CALCOCO1 CCND1 CD82 CEBPB CHUK COL18A1 CTSD DDX17 DDX54 DSCAM EBAG9 EP300 ESR1 ESR2 GREB1 HDAC1 HDAC4 HSF2 JUN KLRC3 LCOR LMO4 MED1 MPG MTA1 MYC NCOA1 NCOA2 NCOA3 NCOA7 NCOR1 NCOR2 NDUFV3 NEDD8 NR0B1 NR0B2 NRIP1 PCNA PDIA2 PGR PHB2 POU4F1 POU4F2 PRDM15 PRL SAFB SET SMAD4 SOD1 SRA1 STAT5A TFF1 TRIM59 UBA3 UBE2M VTLGL1 XBP1 +PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network C3 DDX54 ESR2 NCOA1 NCOA2 NCOA3 NEDD8 NR0B1 NR0B2 SMARCA4 SMARCB1 SMARCE1 UBA3 UBE2M ZNF14 +PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling ABI1 ACTR2 ACTR3 AKT1 ARF4 ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF1 ATF2 BAD BAIAP2 BCL2L1 BRAF BRK1 CAPN2 CDC42 CHN2 CREB1 CYFIP2 DIAPH3 DUSP1 DUSP6 EGF EGFR EGR1 ELK1 EPS8 F2RL2 FOS GAB1 GRB2 HRAS IQGAP1 JUN KRAS KSR1 MAP2K1 MAP2K2 MAP2K4 MAP2K5 MAP3K1 MAP3K2 MAPK1 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAP1 MEF2C MLST8 MTOR MYLPF NCKAP1 NRAS PDPK1 PEBP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLD1 PLD2 PPP2CA PPP2R1A PPP2R2A PPP5C PRKCA PRKCD PRKCZ RAB5A RAC1 RAF1 RALA RALGDS RICTOR RIN1 RPS6 RPS6KA3 RPS6KA4 RPS6KA5 SFN SH2D2A SLC9A1 SMAD1 SOS1 SRC SRF STAT1 STAT3 USP6NL VAV2 WASF2 WASL YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFP36 +PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1 AMPH ARHGEF7 CBL CBLB CDC42 CHMP3 DNM1 EGF EGFR EPN1 EPS15 GRB2 HGS HRAS ITSN1 KRAS LRIG1 NRAS PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTK2 RAB5A RAF1 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY2 SRC STAMBP SYNJ1 TSG101 UBE2D1 UBE2D2 UBE2D3 USP8 ZFYVE28 +PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway EGF EGFR GAB1 GNAI1 GNAI3 GRB2 GSN HRAS KRAS MAPK1 MAPK3 NCK1 NCK2 NRAS PAK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP5K1C PLCG1 PTK2 PTPN1 PTPN11 PTPN6 RASA1 SHC1 SOS1 SRC STAT1 STAT3 TLN1 WASL +PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events AKT1 BAD CDC42 CHRNA1 CHRNE DOCK7 ERBB2 ERBB3 FOS GRB2 HRAS JAK2 JUN KRAS MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MTOR NF2 NFATC4 NRAS NRG1 NRG2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP3CB PRKACA PTPN11 RAC1 RAF1 RNF41 SHC1 SOS1 SRC STAT3 USP8 +PID_ERBB4_PATHWAY ErbB4 signaling events ADAM17 BTC CBFA2T3 DLG4 ERBB2 ERBB4 EREG FYN GRB2 GRIN2B HBEGF ITCH JAK2 LRIG1 MAPK1 MAPK3 MDM2 NCOR1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRL PRLR SHC1 STAT5A STAT5B TAB2 WWOX WWP1 YAP1 +PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network AREG BTC EGF EGFR ERBB2 ERBB3 ERBB4 EREG HBEGF HSP90AA1 NRG1 NRG2 NRG3 NRG4 TGFA +PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase ACTA1 ACTN1 ARHGAP26 ARHGAP35 ARHGEF11 ARHGEF7 ASAP1 BCAR1 BMX BRAF CAPN2 CCND1 CRK DOCK1 ELMO1 ETS1 FYN GIT2 GRB2 GRB7 ITGA5 ITGAV ITGB1 ITGB5 JUN KLF8 MAP2K1 MAP2K4 MAPK1 MAPK8 MAPK8IP3 MAPK9 MMP14 NCK1 NCK2 PAK1 PIK3CA PIK3R1 PLCG1 PTK2 PTPN21 PXN RAC1 RAF1 RAP1A RAP1B RAPGEF1 RASA1 RGNEF RHOA ROCK2 RRAS SH3GL1 SOS1 SRC TLN1 VCL WASL YES1 +PID_FANCONI_PATHWAY Fanconi anemia pathway APITD1 ATM ATR ATRIP BLM BRCA1 BRCA2 BRIP1 C17orf70 C19orf40 CHEK1 FAN1 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM FBXW11 H2AFX HES1 HUS1 MRE11A NBN PALB2 RAD1 RAD17 RAD50 RAD9A RFC2 RFC3 RFC4 RFC5 RMI1 RPA1 RPA2 SSPO TOP3A TOPBP1 UBE2T USP1 WDR48 XRCC3 +PID_FAS_PATHWAY FAS (CD95) signaling pathway AKT1 BID BIRC2 BIRC3 BTK CASP10 CASP3 CASP8 CFLAR CHUK CLTC EZR FADD FAIM2 FAS FASLG IKBKB IKBKG MAP2K6 MAP2K7 MAP3K1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK9 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RFC1 RIPK1 SMPD1 SRC SYK +PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells AKT1 BTK CBL CBLB CHUK DOK1 DUSP1 FCER1A FCER1G FCGR2B FER FOS FYN GAB2 GRB2 HCLS1 HRAS IGHE IKBKB IKBKG INPP5D ITK JUN KLRG1 LAT LAT2 LCP2 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK3 MAPK8 MS4A2 NFATC2 NFKB1 PAK2 PIK3CA PIK3R1 PLA2G1B PLA2G4A PLCG1 PLD2 PPAP2A PRKCB PTK2 PTPN11 PTPN13 PXN RAF1 RASA1 RELA S1PR1 SHC1 SOS1 SPHK1 SYK VAV1 WIPF1 +PID_FGF_PATHWAY FGF signaling pathway AKT1 BGLAP CAMK2A CBL CDH1 CDH2 CTNND1 CTTN FGF1 FGF17 FGF18 FGF19 FGF2 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOS FRS2 GAB1 GRB2 HGF IL17RD JUN KLB MAPK1 MAPK3 MET MMP9 NCAM1 PAK4 PDPK1 PIK3CA PIK3R1 PLAU PLAUR PLCG1 PTK2B PTPN11 RPS6KA1 RUNX2 SDC2 SHC1 SOS1 SPP1 SPRY2 SRC SSH1 STAT1 STAT5B +PID_FOXM1_PATHWAY FOXM1 transcription factor network AURKB BIRC5 BRCA2 CCNA2 CCNB1 CCNB2 CCND1 CCNE1 CDC25B CDK1 CDK2 CDK4 CDKN2A CENPA CENPB CENPF CHEK2 CKS1B CREBBP EP300 ESR1 ETV5 FOS FOXM1 GAS1 GSK3A HIST1H2BA LAMA4 MAP2K1 MMP2 MYC NEK2 NFATC3 ONECUT1 PLK1 RB1 SKP2 SP1 TGFA XRCC1 +PID_FOXO_PATHWAY FoxO family signaling AKT1 BCL2L11 BCL6 CAT CCNB1 CDK2 CDKN1B CHUK CREBBP CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CTNNB1 EP300 FASLG FBXO32 FOXO1 FOXO3 FOXO4 G6PC GADD45A IKBKB KAT2B MAPK10 MAPK8 MAPK9 MST1 PLK1 RALA RALB RAN RBL2 SFN SGK1 SIRT1 SKP2 SOD2 USP7 XPO1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 +PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2 ATF4 BGLAP CCL2 CCNA2 CCND1 CDKN2A COL1A2 DCN DMTF1 EP300 FOSL1 FOSL2 GJA1 HMOX1 IL6 IL8 ITGB4 IVL JUN JUNB JUND LAMA3 LIF MGP MMP1 MMP2 MMP9 NFATC1 NFATC2 NFATC3 NOS3 PLAU PLAUR SP1 THBD TXLNG USF2 +PID_GLYPICAN_1PATHWAY Glypican 1 network APP BLK FGF2 FGFR1 FGR FLT1 FYN GPC1 HCK LAMA1 LCK LYN NRG1 PLA2G2A PRNP SERPINC1 SLIT2 SMAD2 SRC TDGF1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 VEGFA YES1 +PID_GMCSF_PATHWAY GMCSF-mediated signaling events CCL2 CISH CSF2 CSF2RA CSF2RB FOS GAB2 GRB2 HRAS IKBKB INPP5D IRF8 JAK2 KRAS LYN MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS OSM PIK3CA PIK3R1 PIM1 PRKACA PRKACB PRKACG PTPN11 RAF1 SHC1 SOS1 STAT1 STAT3 STAT5A STAT5B SYK YWHAZ +PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I CHD3 CHD4 CREBBP EP300 FKBP3 GATA1 GATA2 GATAD2A GATAD2B HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 KAT2B MAX MBD2 MBD3 MBD3L2 MTA2 MXD1 NCOR1 NCOR2 NFKB1 NFKBIA NR2C1 PPARG PRKACA PRMT5 RAN RANBP2 RANGAP1 RBBP4 RBBP7 RELA SAP18 SAP30 SIN3A SIN3B SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 SMAD7 SMG5 SMURF1 SSPO STAT3 SUMO1 TFCP2 TNF TNFRSF1A UBE2I WDR77 XPO1 YY1 ZFPM1 +PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II ADRBK1 ANKRA2 BCL6 BCOR CAMK4 ESR1 GATA1 GATA2 GNB1 GNG2 HDAC10 HDAC11 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HSP90AA1 MEF2C NCOR2 NR3C1 RAN RANBP2 RANGAP1 RFXANK SRF SUMO1 TUBA1B TUBB2A UBE2I XPO1 YWHAB YWHAE +PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III ACSS1 ACSS2 BAX CDKN1A CREBBP EP300 FHL2 FOXO1 FOXO3 FOXO4 HDAC4 HIST1H1E HOXA10 KAT2B MEF2D MYOD1 PPARGC1A SIRT1 SIRT2 SIRT3 SIRT7 TP53 TUBA1B TUBB2A XRCC6 +PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family ADRBK1 AKT1 ARRB2 BOC CDON DHH GAS1 GLI2 HHAT HHIP IHH LRP2 LRPAP1 PIK3CA PIK3R1 PTCH1 PTCH2 PTHLH SHH SMO STIL TGFB2 +PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins AKT1 ARRB2 CREBBP CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 FBXW11 FOXA2 GLI1 GLI2 GLI3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNG2 GSK3B HDAC1 HDAC2 IFT172 IFT88 KIF3A LGALS3 MAP2K1 MTSS1 PIAS1 PRKACA PRKCD PTCH1 RAB23 RBBP4 RBBP7 SAP18 SAP30 SHH SIN3A SIN3B SMO SPOP SSPO STK36 SUFU XPO1 +PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network AR ARNT ASCL1 BGLAP CAMK2D CD4 CDKN1B CREBBP CTBP1 E2F1 EP300 GAA GATA1 GATA4 GATA6 GHR HDAC1 HES1 HES6 HEY1 HEY2 HIF1A ID1 JAK2 KDM1A KDR MAML1 MAML2 MYB MYOD1 NCOA1 NCOR1 NCOR2 NEUROG3 NOTCH1 PARP1 PTF1A RB1 RBBP8 RBPJ RCAN1 RUNX2 SPEN STAT3 TCF3 TLE1 TWIST1 YY1 +PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network ABCB1 ABCG2 ADM AKT1 ALDOA ARNT BHLHE40 BHLHE41 BNIP3 CA9 CITED2 COPS5 CP CREB1 CREBBP CXCL12 CXCR4 EDN1 EGLN1 EGLN3 ENG ENO1 EP300 EPO ETS1 FECH FOS FURIN GATA2 GCK HDAC7 HIF1A HK1 HK2 HMOX1 HNF4A ID2 IGFBP1 ITGB2 JUN LDHA LEP MCL1 NCOA1 NCOA2 NDRG1 NOS2 NPM1 NT5E PFKFB3 PFKL PGK1 PGM1 PKM2 PLIN2 RORA SERPINE1 SLC2A1 SMAD3 SMAD4 SP1 TERT TF TFF3 TFRC VEGFA +PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ARNT CDKN2A COPS5 CUL2 EGLN1 EGLN2 EGLN3 GNB2L1 HIF1A HIF1AN HIF3A HSP90AA1 NAA10 OS9 RBX1 TCEB1 TCEB2 TP53 VHL +PID_HIF2PATHWAY HIF-2-alpha transcription factor network ABCG2 ADORA2A APEX1 ARNT BHLHE40 CITED2 CREBBP EFNA1 EGLN1 EGLN2 EGLN3 EIF3E ELK1 EP300 EPAS1 EPO ETS1 FLT1 FXN HIF1AN KDR MMP14 PGK1 POU5F1 SERPINE1 SIRT1 SLC11A2 SLC2A1 SP1 TCEB1 TCEB2 TWIST1 VEGFA VHL +PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha APAF1 BAG4 BCL2 BID BIRC3 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CD247 CFLAR CHUK CRADD CYCS DAXX DFFA DFFB FADD FAS FASLG MAP2K7 MAP3K14 MAP3K5 MAPK8 NFKB1 NFKBIA RELA RIPK1 TNF TNFRSF1A TRADD TRAF1 TRAF2 +PID_HNF3A_PATHWAY FOXA1 transcription factor network AP1B1 APOB AR ATP5J BRCA1 C4BPB CDKN1B CEBPB COL18A1 CREBBP CYP2C18 DSCAM EP300 ESR1 FOS FOXA1 FOXA2 FOXA3 GCG INS JUN KLK3 NCOA3 NDUFV3 NFIA NFIB NFIC NKX3-1 NR2F2 NRIP1 PISD POU2F1 PRDM15 SCGB1A1 SERPINA1 SFTPA1 SFTPA2 SFTPD SHH SOD1 SP1 TFF1 VTN XBP1 +PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks ABCC8 ACADM ACADVL AFP AKT1 ALAS1 ALB ALDOB APOA1 BDH1 CEBPA CEBPB CEBPD CPT1A CPT1B CPT1C CREB1 DLK1 F2 FOXA1 FOXA2 FOXA3 FOXF1 G6PC GCK HADH HMGCS1 HNF1A HNF1B HNF4A IGFBP1 INS KCNJ11 NF1 NKX2-1 NR3C1 PCK1 PDX1 PKLR SLC2A2 SP1 TAT TFRC TTR UCP2 +PID_IFNG_PATHWAY IFN-gamma pathway AKT1 CAMK2A CAMK2B CAMK2D CAMK2G CASP1 CBL CEBPB CREBBP CRKL DAPK1 EP300 IFNG IFNGR1 IL1B IRF1 IRF9 JAK1 JAK2 MAP2K1 MAP3K1 MAP3K11 MAPK1 MAPK3 MTOR PIAS1 PIAS4 PIK3CA PIK3R1 PRKCD PTGES2 PTPN11 PTPN2 RAP1A RAP1B RAPGEF1 SMAD7 SOCS1 STAT1 STAT3 +PID_IGF1_PATHWAY IGF1 pathway AKT1 BAD BCAR1 CRK CRKL GNB2L1 GRB10 GRB2 HRAS IGF1 IGF1R IRS1 IRS2 NCK2 PDPK1 PIK3CA PIK3R1 PRKCD PRKCZ PRKD1 PTK2 PTPN1 PTPN11 PXN RAF1 RPS6KB1 SHC1 SOS1 YWHAE YWHAZ +PID_IL12_2PATHWAY IL12-mediated signaling events ATF2 B2M CCL3 CCL4 CCR5 CD247 CD3D CD3E CD3G CD4 CD8A CD8B EOMES FASLG FOS GADD45B GADD45G GZMA GZMB HLA-A HLA-DRA HLA-DRB1 HLX IFNG IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IL18RAP IL1B IL1R1 IL2 IL2RA IL2RB IL2RG IL4 JAK2 LCK MAP2K3 MAP2K6 MAPK14 MTOR NFKB1 NFKB2 NOS2 PPP3CA PPP3CB PPP3R1 RAB7A RELA RELB RIPK2 SOCS1 SPHK2 STAT1 STAT3 STAT4 STAT5A STAT6 TBX21 TYK2 +PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CREBBP ETV5 FOS HLA-DRA HLA-DRB1 IFNG IL13 IL18 IL18R1 IL18RAP IL2 IL2RA IRF1 JUN MAPK8 MAPK9 PIAS2 PPP3CA PPP3CB PPP3R1 PRF1 STAT3 STAT4 TBX21 TGFB1 +PID_IL1_PATHWAY IL1-mediated signaling events CASP1 CHUK ERC1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK3 IRAK4 JUN MAP2K6 MAP3K3 MAP3K7 MAPK8 MYD88 NFKB1 PIK3CA PIK3R1 PRKCI PRKCZ RELA SQSTM1 TAB1 TAB2 TICAM2 TOLLIP TRAF6 UBE2N UBE2V1 +PID_IL23_PATHWAY IL23-mediated signaling events ALOX12B CCL2 CD3E CD4 CXCL1 CXCL9 IFNG IL12B IL12RB1 IL17A IL17F IL18 IL18R1 IL18RAP IL19 IL1B IL2 IL23A IL23R IL24 IL6 ITGA3 JAK2 MPO NFKB1 NFKBIA NOS2 PIK3CA PIK3R1 RELA SOCS3 STAT1 STAT3 STAT4 STAT5A TNF TYK2 +PID_IL27_PATHWAY IL27-mediated signaling events EBI3 GATA3 IFNG IL12A IL12B IL12RB1 IL12RB2 IL17A IL18 IL1B IL2 IL27 IL27RA IL6 IL6ST JAK1 JAK2 STAT1 STAT2 STAT3 STAT4 STAT5A TBX21 TGFB1 TNF TYK2 +PID_IL2_1PATHWAY IL2-mediated signaling events BCL2 CDK2 CISH DOK2 FOS FYN GAB2 GRB2 HRAS IFNG IKZF3 IL2 IL2RA IL2RB IL2RG IRS1 IRS2 JAK1 JAK3 JUN KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MYC NRAS PIK3CA PIK3R1 PPP2R5D PRKCB PRKCE PTK2B PTPN11 RAF1 RASA1 RHOA SHC1 SOCS1 SOCS2 SOCS3 SOS1 STAM STAM2 STAT1 STAT3 STAT5A STAT5B SYK +PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K AKT1 BCL2 BCL2L1 E2F1 EIF3A FOXO3 GAB2 GRB2 HSP90AA1 IL2 IL2RA IL2RB IL2RG JAK1 JAK3 LCK MTOR MYB MYC NFKB1 PIK3CA PIK3R1 PRKCZ PTPN11 RAC1 RELA RPS6 RPS6KB1 SGMS1 SHC1 SMPD1 SOS1 TERT UGCG +PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5 BCL2 BCL2L1 CCNA2 CCND2 CCND3 CDK6 ELF1 FASLG FOXP3 GAB2 GRB2 IL2 IL2RA IL2RB IL2RG IL4 JAK1 JAK3 LCK LTA MYC PIK3CA PIK3R1 PRF1 PTPN11 SHC1 SOS1 SP1 STAT5A STAT5B +PID_IL3_PATHWAY IL3-mediated signaling events BCL2L1 CEBPB CISH CNKSR1 CSF2RB GAB2 GRB2 HDAC1 ID1 IL3 IL3RA INPP5D JAK2 OSM PIK3CA PIK3R1 PIM1 PRKACA PRKACB PRKACG PTPN11 SHC1 SRP9 STAT5A STAT5B YWHAG YWHAZ +PID_IL4_2PATHWAY IL4-mediated signaling events AICDA AKT1 ALOX15 ARG1 BCL2L1 BCL6 CBL CCL11 CCL17 CCL26 CD40LG CEBPB COL1A1 COL1A2 DOK2 EGR2 ETS1 FCER2 FES GRB2 GTF3A HMGA1 IGHE IGHG1 IGHG3 IL10 IL13RA1 IL13RA2 IL2RG IL4 IL4R IL5 INPP5D IRF4 IRS1 IRS2 ITGB3 JAK1 JAK2 JAK3 LTA MAPK14 MTOR MYB MYBL1 OPRM1 PARP14 PIGR PIK3CA PIK3R1 PTPN6 RETNLB RPS6KB1 SELP SHC1 SOCS1 SOCS3 SOCS5 SP1 SPI1 STAT5A STAT5B STAT6 TFF3 THY1 +PID_IL5_PATHWAY IL5-mediated signaling events CISH CSF2RB GRB2 IL5 IL5RA JAK2 LYN PIK3CA PIK3R1 PIM1 PTPN11 SDCBP STAT5A STAT5B +PID_IL6_7_PATHWAY IL6-mediated signaling events A2M AKT1 BCL2L1 CEBPB CEBPD CRP FGG FOS FOXO1 GAB1 GAB2 GRB2 HCK HSP90B1 IL6 IL6R IL6ST IRF1 JAK1 JAK2 JUN JUNB LBP LMO4 MAP2K4 MAP2K6 MAPK11 MAPK14 MCL1 MITF MYC PIAS1 PIAS3 PIK3CA PIK3R1 PRKCD PTPN11 PTPRE RAC1 SOCS3 SOS1 STAT1 STAT3 TIMP1 TNFSF11 TYK2 VAV1 +PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events ADRBK1 AKT1 ARRB1 ARRB2 CBL CXCR1 DNM1 FGR GNA14 GNA15 GNAI2 GNB1 GNG2 HCK IL8 LYN PDPK1 PIK3CG PIK3R6 PLCB1 PLCB2 PLCB3 PLD1 PRKCA PRKCB PRKCE PRKCG RAB5A +PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events AKT1 ARRB1 ARRB2 CBL CXCR2 DNM1 DOCK2 ELMO1 FGR GNA14 GNA15 GNAI2 GNB1 GNG2 HCK IL8 LYN PDPK1 PIK3CG PIK3R6 PLCB1 PLCB2 PLCB3 PLD2 PPP2CA PPP2R1A PRKCA PRKCB PRKCG RAB11A RAB5A RAB7A RAC2 VASP +PID_ILK_PATHWAY Integrin-linked kinase signaling ACTN1 AKT1 ARHGEF6 ARHGEF7 AURKA CCND1 CDC37 CDC42 CKAP5 CREB1 CTNNB1 DIAPH1 ELMO2 GIT2 GSK3B HSP90AA1 ILK ILKAP IQGAP1 JUN LIMS1 LIMS2 MYL9 NACA NCK2 PARP1 PARVA PARVB PARVG PPP1R12A PPP1R14A PPP1R14B PPP1R14C PXN RAC1 RHOG RICTOR RUVBL1 RUVBL2 SNAI1 TACC3 TNS1 XPO1 ZEB1 ZYX +PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport AKT1 AKT2 ASIP GSK3B GYS1 INS INSR LNPEP PPP1CC PPP1R3A PRKCI PRKCZ RHOQ SFN SLC2A4 STX4 STXBP4 TBC1D4 TRIP10 VAMP2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_INSULIN_PATHWAY Insulin Pathway AKT1 AKT2 CAV1 CBL CRK DOK1 EIF4EBP1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 F2RL2 FOXO3 GRB10 GRB14 GRB2 HRAS INPP5D INS INSR IRS1 NCK1 NCK2 PARD6A PDPK1 PIK3CA PIK3R1 PRKCI PRKCZ PTPN1 PTPN11 PTPRA RAPGEF1 RASA1 RHOQ RPS6KB1 SGK1 SH2B2 SHC1 SORBS1 SOS1 TRIP10 +PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions CD14 CD81 COL11A1 COL11A2 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL7A1 CSPG4 F13A1 FBN1 FGA FGB FGG FN1 IGSF8 ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 JAM2 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 MDK NID1 NPNT PLAU PLAUR SPP1 TGFBI TGM2 THBS1 THBS2 TNC VCAM1 VEGFA VTN +PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions C3 CD40LG CYR61 F10 F11R FCGR2A FGA FGB FGG GP1BA ICAM1 ICAM2 ICAM3 ICAM4 ITGAD ITGAL ITGAM ITGAX ITGB2 JAM3 KNG1 PLAT PLAU PLAUR PROC SPON2 TGFBI THY1 VCAM1 +PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions CD47 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 CYR61 EDIL3 F11R FBN1 FGA FGB FGG FN1 HMGB1 IBSP ITGA2B ITGAV ITGB3 KDR L1CAM LAMA4 LAMB1 LAMC1 PDGFB PDGFRB PECAM1 PLAU PLAUR PVR SDC1 SDC4 SPHK1 SPP1 TGFBI TGFBR2 THBS1 THY1 TNC VEGFA VTN +PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions ITGA6 ITGB4 LAMA1 LAMA2 LAMA3 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 +PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions CYR61 EDIL3 FBN1 FN1 ITGA4 ITGAV ITGB5 ITGB6 ITGB7 ITGB8 MADCAM1 PLAU PLAUR SDC1 TGFBR1 VCAM1 VTN +PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events ABI1 ADAM28 AMICA1 ARF6 BCAR1 CD14 CD81 CRK DOCK1 FN1 GIT1 IGSF8 ITGA4 ITGB1 JAM2 MDK MYH2 PRKACA PRKACB PRKAR1A PRKAR1B PTK2 PTK2B PTPRA PXN RAC1 SPP1 SRC THBS1 THBS2 TLN1 VCAM1 YWHAZ +PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events ADAM12 ADAM15 ADAM2 ADAM8 BCAR1 CSF2 CSF2RA F13A1 FIGF FN1 ITGA9 ITGB1 KCNJ15 NOS2 PAOX PXN RAC1 SAT1 SPP1 SRC TGM2 TNC VCAM1 VEGFA VEGFC +PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 +PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit) AKT1 BAD BCL2 CBL CREBBP CRKL DOK1 EPO EPOR FER FOXO3 GAB1 GRAP2 GRB10 GRB2 GSK3B HRAS JAK2 KIT KITLG LYN MAP2K1 MAP2K2 MAP4K1 MAPK3 MAPK8 MATK MITF PDPK1 PIK3C2B PIK3CA PIK3R1 PTEN PTPN11 PTPN6 PTPRO RAF1 RPS6KB1 SH2B2 SH2B3 SHC1 SNAI2 SOCS1 SOS1 SPRED1 SPRED2 STAP1 STAT1 STAT3 STAT5A TEC VAV1 +PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development ABL1 CDC42 CDK5 CDK5R1 CDK5R2 CLIP1 CSNK2A1 DAB1 DCX DYNC1H1 DYNLT1 IQGAP1 KATNA1 LRP8 LRPAP1 MAP1B NDEL1 NUDC PAFAH1B1 PAFAH1B2 PAFAH1B3 PLA2G7 PPP2R5D RAC1 RELN RHOA VLDLR YWHAE +PID_LKB1_PATHWAY LKB1 signaling events AKT1S1 BRSK1 BRSK2 CAB39 CDC37 CREB1 CRTC2 CTSD ESR1 ETV4 EZR GSK3B HSP90AA1 MAP2 MAPT MARK2 MARK4 MLST8 MST4 MTOR MYC PRKAA1 PRKAA2 PRKAB1 PRKACA PRKAG1 PSEN2 RPTOR SFN SIK1 SIK2 SIK3 SMAD4 SMARCD3 STK11 STK11IP STRADA STRADB TP53 TSC1 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_LPA4_PATHWAY LPA4-mediated signaling events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CREB1 GNAL LPAR4 PRKACA PRKCE RPS6KA5 +PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium AKT1 COL1A1 COL1A2 CREB1 CRK FIGF FLT4 FN1 GRB2 ITGA1 ITGA2 ITGA4 ITGA5 ITGB1 MAP2K4 MAPK1 MAPK11 MAPK14 MAPK3 PIK3CA PIK3R1 RPS6KA1 SHC1 SOS1 VEGFC +PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA1B AKT1 ARHGEF1 BCAR1 CASP3 CRK EGFR FOS GAB1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ GNB1 GNG2 GSK3B HBEGF HRAS IL6 IL8 JUN LPAR1 LPAR2 LPAR3 LPAR4 LYN MAGI3 MAPT MMP2 MMP9 NFKB1 NFKBIA PIK3CB PIK3R1 PLCB3 PLCG1 PLD2 PRKCD PRKCE PRKD1 PTK2 PTK2B PXN RAC1 RELA RHOA SLC9A3R2 SRC TIAM1 TRIP6 +PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway BRAF CDK5 CDK5R1 CREB1 EGR1 EHD4 ELK1 FOS HRAS KRAS MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K2 MAPK1 MAPK14 MAPK3 MAPK7 MAPKAPK2 MEF2C NRAS NTF3 PRKCD RAF1 RAP1A RAP1B RIT1 RIT2 RPS6KA1 RPS6KA5 RUSC1 SRF TRPV1 +PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) AKT1 AKT1S1 AKT2 APC ARF6 ARHGEF4 BAD BCAR1 CBL CDC42 CDH1 CRK CRKL CTNNA1 CTNNB1 DEPTOR EGR1 EIF4E EIF4EBP1 EPS15 ETS1 F2RL2 GAB1 GAB2 GRB2 HGF HGS HRAS INPP5D INPPL1 JUN KPNB1 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAPK1 MAPK3 MAPK8 MET MLST8 MTOR MUC20 NCK1 NCK2 NUMB PAK1 PAK2 PAK4 PARD6A PDPK1 PIK3CA PIK3R1 PLCG1 PRKCI PRKCZ PTK2 PTPN1 PTPN11 PTPN2 PTPRJ PXN RAB5A RAC1 RAF1 RANBP10 RANBP9 RAP1A RAP1B RAPGEF1 RHOA RIN2 RPTOR SH3GL2 SH3KBP1 SHC1 SNAI1 SOS1 SRC WASL +PID_MTOR_4PATHWAY mTOR signaling pathway AKT1 AKT1S1 ATG13 BNIP3 BRAF CCNE1 CDK2 CLIP1 CYCS DDIT4 DEPTOR EEF2 EEF2K EIF4A1 EIF4B EIF4E EIF4EBP1 FBXW11 HRAS IKBKB IRS1 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MLST8 MTOR NRAS PDCD4 PDPK1 PLD1 PLD2 PML POLDIP3 PPARGC1A PRKCA PRR5 PXN RAC1 RAF1 RB1CC1 RHEB RHOA RICTOR RPS6KA1 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD RRN3 SFN SGK1 SREBF1 SSPO TSC1 TSC2 ULK1 ULK2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 +PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation ACTL6A BAX BCAT1 BIRC5 BMI1 CAD CCNB1 CCND2 CDC25A CDCA7 CDK4 CREBBP DDX18 E2F3 EIF2S1 EIF4A1 EIF4E EIF4G1 ENO1 EP300 FOSL1 GAPDH GPAM HMGA1 HSP90AA1 HSPA4 HSPD1 HUWE1 ID2 IREB2 KAT2A KAT5 KIR3DL1 LDHA LIN28B MAX MINA MMP9 MTA1 MTDH MYC MYCT1 NBN NCL NDUFAF2 NME1 NME2 NPM1 ODC1 PDCD10 PEG10 PFKM PIM1 PMAIP1 POLR3D PRDX3 PTMA RCC1 RPL11 RUVBL1 RUVBL2 SERPINI1 SHMT1 SLC2A1 SMAD3 SMAD4 SNAI1 SUPT3H SUPT7L TAF10 TAF12 TAF4B TAF9 TERT TFRC TK1 TP53 TRRAP UBTF +PID_MYC_PATHWAY C-MYC pathway ACTL6A AXIN1 CDKN2A FBXW7 GSK3B HBP1 KAT2A KAT5 MAX MYC PAK2 PIN1 PML PPP2CA PPP2R5A RUVBL1 RUVBL2 SKP2 SUPT3H SUPT7L TAF10 TAF12 TAF9 TRRAP ZBTB17 +PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression ALDH9A1 BCL2 BRCA1 CCL5 CCND1 CDKN1A CDKN1B CDKN2B CEBPA CEBPD CFLAR CLU COL1A2 CREB1 CSDE1 DDIT3 DKK1 DNMT3A DNTT EP300 ERBB2 FOXO3 FTH1 GADD45A GFI1 GTF2H2 HDAC1 HDAC3 HMGCS2 ID2 IRF8 ITGA6 ITGB1 ITGB4 LGALS1 MAX MXD4 MYC NDRG1 NDRG2 NFYA NFYB NFYC PDGFRB PPP2R4 RBL1 S100A7 SFRP1 SFXN3 SLC11A1 SMAD2 SMAD3 SMAD4 SP1 SPI1 TBP TJP2 TMEFF2 TMEM126A TSC2 WNT5A ZBTB17 ZFP36L1 +PID_NCADHERIN_PATHWAY N-cadherin signaling events AXIN1 CAMK2G CDC42 CDH2 CNR1 CTNNA1 CTNNB1 CTNND1 CTTN DAGLA DAGLB DCTN1 FER FGFR1 GAP43 GJA1 GRIA2 GSN JUP KIF5B LRP5 MAPK8 MAPRE1 MYL2 PIK3CA PIK3R1 PIP5K1C PLCG1 PTPN1 PTPN11 RAC1 RHOA ROCK1 +PID_NECTIN_PATHWAY Nectin adhesion pathway CDC42 CDH1 CLDN1 CRK CTNNA1 CTNNB1 F11R FARP2 IQGAP1 ITGAV ITGB3 MLLT4 PDGFB PDGFRB PIK3CA PIK3R1 PIP5K1C PTK2 PTPRM PVR PVRL1 PVRL2 PVRL3 RAC1 RAP1A RAP1B RAPGEF1 SRC TLN1 VAV2 +PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte AKT1 ARRB2 BAD CD2AP F2RL2 FYN GRB2 JUN KIRREL MAP2K4 MAPK10 MAPK8 MAPK9 NCK1 NCK2 NPHS1 NPHS2 PARD6A PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKCI PRKCZ RAC1 TJP1 TRPC6 WASL +PID_NETRIN_PATHWAY Netrin-mediated signaling events AGAP2 BCAR1 CAMK2A CDC42 DAPK1 DCC DOCK1 ELMO1 FYN MAP1B MAP2K1 MAP2K2 MAPK1 MAPK3 MYO10 NCK1 NTN1 PAK1 PIK3CA PIK3R1 PITPNA PLCG1 PTK2 RAC1 RHOA SRC TRIO UNC5A UNC5B UNC5C WASL YES1 +PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes AKAP5 BAD BAX BCL2 BCL2L1 CABIN1 CAMK4 CASP3 CHP CREBBP CSNK1A1 CSNK2A1 EP300 FKBP1A FKBP8 GSK3B KPNA2 KPNB1 MAP3K1 MAP3K8 MAPK14 MAPK3 MAPK8 MAPK9 MEF2D NFATC1 NFATC2 NFATC3 NR4A1 NUP214 PIM1 PPP3CA PPP3CB PPP3R1 PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RAN RCAN1 RCAN2 SFN XPO1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes BATF3 CASP3 CBLB CD40LG CDK4 CREM CSF2 CTLA4 DGKA E2F1 EGR1 EGR2 EGR3 EGR4 FASLG FOS FOSL1 FOXP3 GATA3 GBP3 IFNG IKZF1 IL2 IL2RA IL3 IL4 IL5 IL8 IRF4 ITCH JUN JUNB MAF NFATC1 NFATC2 NFATC3 POU2F1 PPARG PRKCQ PTGS2 PTPN1 PTPRK RNF128 SLC3A2 TBX21 TLE4 TNF +PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway ARRB2 BCL3 CSNK2A1 CSNK2A2 CSNK2B IKBKB LCK MAPK14 NFKB1 NFKBIA PIK3CA PIK3R1 REL RELA SRC SSPO SYK +PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway ATM BCL10 BIRC2 CHUK CYLD ERC1 IKBKB IKBKG MALT1 NFKB1 NFKBIA NOD2 PRKCA RAN RELA RIPK2 SSPO TNF TNFAIP3 TNFRSF1A TRAF6 UBE2D3 XPO1 +PID_NOTCH_PATHWAY Notch signaling pathway ADAM10 ADAM12 APH1A APH1B CBL CCND1 CDKN1A CNTN1 CNTN6 CTBP1 CUL1 DLK1 DLL1 DLL3 DLL4 DNER DNM1 DTX1 ENO1 EP300 EPS15 FBXW7 FURIN GATA3 HDAC1 IL4 ITCH JAG1 JAG2 KDM1A LNX1 MAML1 MAML2 MARK2 MFAP2 MFAP5 MIB1 MYC MYCBP NCOR1 NCOR2 NCSTN NEURL NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUMB PSEN1 PSENEN PTCRA RAB11A RBBP8 RBPJ SKP1 SKP2 SPEN SSPO YY1 +PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta ATF1 ATF2 ATF6 CEBPB CREB1 CSNK2A1 CSNK2A2 CSNK2B DDIT3 EIF4E EIF4EBP1 ELK4 ESR1 GDI1 HBP1 HSPB1 JUN KRT19 KRT8 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MEF2A MEF2C MITF MKNK1 NOS2 PLA2G4A PPARGC1A PTGS2 RAB5A RPS6KA4 RPS6KA5 SLC9A1 TP53 USF1 +PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta BLK CCM2 CDC42 DUSP1 DUSP10 DUSP16 DUSP8 FGR FYN HCK LCK LYN MAP2K3 MAP2K4 MAP2K6 MAP3K12 MAP3K3 MAPK11 MAPK14 PAK1 PAK2 PAK3 PRKG1 RAC1 RALA RALB RIPK1 SRC TAB1 TRAF6 YES1 +PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta CCND1 EEF2K MAP2K3 MAP2K6 MAPK12 MAPK13 MAPT PKN1 SNTA1 STMN1 ZAK +PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases CDC25B CREB1 ETV1 HSPB1 LSP1 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 RAF1 SFN SRF TCF3 TH TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway ATM CAMK2B CCM2 GADD45A GADD45B GADD45G MAP2K3 MAP2K6 MAP3K1 MAP3K10 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAPK11 MAPK14 RAC1 TAB1 TAB2 TAOK1 TAOK2 TAOK3 TRAF2 TRAF6 TXN +PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors AFP AIFM2 APAF1 APC ARID3A ATF3 BAK1 BAX BBC3 BCL2 BCL2A1 BCL2L1 BCL2L14 BCL2L2 BCL6 BDKRB2 BID BNIP3L BTG2 C12orf5 C13orf15 CARM1 CASP1 CASP10 CASP6 CAV1 CCNB1 CCNG1 CCNK CD82 CDKN1A CEBPZ COL18A1 CREBBP CSE1L CTSD CX3CL1 DDB2 DDIT4 DDX5 DGCR8 DKK1 DROSHA DUSP1 DUSP5 E2F1 E2F2 E2F3 EDN2 EGFR EP300 EPHA2 FAS FDXR FOXA1 GADD45A GDF15 GPX1 HDAC2 HGF HIC1 HTT IGFBP3 IRF5 JMY JUN KAT2A LIF MAP4K4 MCL1 MDM2 MET MLH1 MMP2 MSH2 NDRG1 NFYA NFYB NFYC NLRC4 PCBP4 PCNA PERP PIDD PLK3 PMAIP1 PML PMS2 POU4F1 POU4F2 PPM1J PPP1R13B PRDM1 PRKAB1 PRMT1 PTEN PYCARD RB1 RCHY1 RFWD2 RNF144B RPS27L RRM2B S100A2 SCN3B SERPINB5 SERPINE1 SESN1 SFN SH2D1A SMARCA4 SNAI2 SP1 SPP1 STEAP3 TADA2B TAF9 TAP1 TFDP1 TGFA TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TP53 TP53BP2 TP53I3 TP53INP1 TP63 TP73 TRIAP1 TRRAP TSC2 TYRP1 VCAN VDR ZNF385A +PID_P53_REGULATION_PATHWAY p53 pathway ABL1 AKT1 ATM ATR CCNA2 CCNG1 CDK2 CDKN2A CHEK1 CHEK2 CREBBP CSE1L CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 DAXX DYRK2 E4F1 EP300 FBXO11 GSK3B HIPK2 HUWE1 KAT2B KAT5 KAT8 MAPK14 MAPK8 MAPK9 MDM2 MDM4 NEDD8 PIN1 PPM1D PPP1R13L PPP2CA PPP2R4 PRKCD PRMT5 RASSF1 RCHY1 RFWD2 RPL11 RPL23 RPL5 SETD7 SETD8 SKP2 SMYD2 TP53 TP53AIP1 TRIM28 TTC5 UBE2D1 USP7 YY1 +PID_P73PATHWAY p73 transcription factor network ABL1 ADA AEN AFP BAK1 BAX BBC3 BCL2L11 BIN1 BRCA2 BUB1 BUB3 CASP2 CCNA2 CCNB1 CCNE2 CDK1 CDK2 CDK6 CDKN1A CHEK1 CLCA2 D4S234E DCP1B DEDD EP300 FAS FASN FBXO45 FLOT2 FOXO3 GATA1 GDF15 GNB2L1 GRAMD4 HAGH HEY2 HSF1 IL1RAP IL4R ITCH JAG2 JAK1 KAT5 MAPK11 MAPK14 MDM2 MYC NDUFS2 NEDD4L NTRK1 PEA15 PFDN5 PIN1 PLK1 PLK3 PML PPAP2A PRKACB RAD51 RB1 RCHY1 RELA RNF43 S100A2 SERPINA1 SERPINE1 SFN SIRT1 SP1 TP53AIP1 TP53I3 TP63 TP73 TUBA1A UBE4B WT1 WWOX YAP1 +PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling ADAM17 AKT1 APAF1 APH1A APH1B APP ARHGDIA BAD BCL2L11 BDNF BEX1 BIRC2 BIRC3 CASP3 CASP6 CASP9 CHUK CYCS DIABLO E2F1 FURIN IKBKB IKBKG IRAK1 LINGO1 MAG MAGED1 MAGEH1 MAPK10 MAPK8 MAPK9 MMP3 MMP7 MYD88 NCSTN NDN NDNL2 NGF NGFR NGFRAP1 NTF3 NTF4 NTRK1 OMG PIK3CA PIK3R1 PLG PRDM4 PRKACB PRKCI PRKCZ PSEN1 PSENEN RAC1 RHOA RHOB RHOC RIPK2 RTN4 RTN4R SHC1 SMPD2 SORT1 SQSTM1 TP53 TRAF6 XIAP YWHAE ZNF274 +PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway CAV1 CAV3 CRK CRKL CSNK2A1 ELK1 FOS GRB2 IFNG ITGAV JAK1 JUN PDGFRA PIK3CA PIK3R1 PLCG1 RAPGEF1 SHB SHC1 SHF SOS1 SRF +PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway ABI1 ABL1 ACTA2 ACTN4 ACTR2 ACTR3 ARAP1 ARHGAP35 ARHGDIA ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BCAR1 BLK BRAF BRK1 CBL CRK CSK CTTN CYFIP2 DNM2 DOCK4 DOK1 EIF2AK2 ELK1 EPS8 FGR FOS FYN GAB1 GRB10 GRB2 HCK HRAS IQGAP1 ITGAV ITGB3 JAK2 JUN JUND KRAS KSR1 LCK LRP1 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MLLT4 MYC MYOCD NCK1 NCK2 NCKAP1 NRAS PAG1 PAK1 PDGFB PDGFRB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIN1 PLA2G4A PLCG1 PPP2CA PPP2R1A PPP2R2B PRKCA PRKCD PRKCE PTEN PTPN1 PTPN11 PTPN2 PTPRJ RAB4A RAB5A RAC1 RAF1 RAP1A RAP1B RAPGEF1 RASA1 RHOA RPS6KA3 S1PR1 SFN SHC1 SIPA1 SLA SLC9A3R1 SLC9A3R2 SOS1 SPHK1 SRC SRF STAT1 STAT3 STAT5A STAT5B TAGLN USP6NL VAV2 WASF2 WASL YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma AGAP2 AKT1 BAD CAMK2A CAMK4 CCND1 CREB1 EGR1 EPB41L1 FOXO3 GAB1 GRB2 GSK3B HRAS KRAS NGF NRAS NTRK1 PDPK1 PIK3CA PIK3R1 PLCG1 PRKCD SFN SHC1 SOS1 SRC STAT5A TRPC3 TRPV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt AKT1 AKT2 AKT3 BAD BCL2L1 CASP9 CDKN1A CDKN1B CHUK FOXO1 FOXO3 FOXO4 GSK3A GSK3B HSP90AA1 KPNA1 MAP3K5 MAPKAP1 MLST8 MTOR PDPK1 PRKACA PRKDC RAF1 RICTOR SFN SLC2A4 SRC TBC1D4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +PID_PI3KCI_PATHWAY Class I PI3K signaling events ADAP1 ARAP3 ARF1 ARF5 ARF6 BLK BLNK BTK CYTH1 CYTH2 CYTH3 DAPP1 FGR FOXO3 FYN HCK HRAS HSP90AA1 INPP5D INPPL1 ITK KRAS LAT LCK LYN NRAS PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCG1 PLCG2 PLEKHA1 PLEKHA2 PTEN RAC1 RAP1A RHOA SGK1 SRC SYK YES1 ZAP70 +PID_PLK1_PATHWAY PLK1 signaling events AURKA BORA BUB1 BUB1B CCNB1 CDC14B CDC20 CDC25B CDC25C CDK1 CENPE CLSPN ECT2 ERCC6L FBXO5 FBXW11 FZR1 GOLGA2 GORASP1 INCENP KIF20A KIF2A MLF1IP NDC80 NINL NUDC ODF2 PAK1 PLK1 PLK1S1 PPP1CB PPP1R12A PPP2CA PPP2R1A PRC1 RAB1A RHOA ROCK2 SGOL1 SPC24 SSPO STAG2 TPT1 TPX2 TUBG1 WEE1 +PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL AGT ATF5 BCAR1 CCNA2 CCNE1 CDK2 CDKN1A EGR1 ITGA1 ITGB1 MAPK1 MAPK3 PTP4A1 PTP4A2 PTP4A3 RABGGTA RABGGTB RAC1 RHOA RHOC ROCK1 SRC TUBA1B +PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling ADAM10 AES APC APH1A APH1B AXIN1 CCND1 CREBBP CSNK1A1 CSNK2A1 CTBP1 CTNNB1 DKK1 DKK2 DLL1 DTX1 DVL1 FBXW11 FOS FRAT1 FZD1 GSK3B HDAC1 HNF1A JUN KREMEN2 LRP6 MAP3K7 MAPK1 MAPK3 MYC NCSTN NEDD4 NKD1 NLK NOTCH1 PPARD PPP2R5D PSEN1 PSENEN RBPJ SSPO TAB1 TLE1 WIF1 WNT1 +PID_PTP1B_PATHWAY Signaling events mediated by PTP1B AKT1 BCAR1 BLK CAPN1 CAV1 CDH2 CRK CSF1 CSF1R CSK CSN2 DOK1 EGF EGFR FCGR2A FER FGR FYN GRB2 HCK INS INSR IRS1 ITGA2B ITGB3 JAK2 LAT LCK LEP LEPR LYN NOX4 PDGFB PDGFRB PIK3CA PIK3R1 PRL PRLR PTPN1 RHOA SHC1 SOCS3 SPRY2 SRC STAT3 STAT5A STAT5B TRPV6 TXN TYK2 YBX1 YES1 +PID_RAC1_PATHWAY RAC1 signaling pathway ABI1 ABI2 ACTR2 ACTR3 ARHGAP5 ARHGDIA ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF2 BAIAP2 BCAR1 BRK1 CDH1 CFL1 CRK CTNNA1 CTNNB1 CYBA CYBB CYFIP2 IQGAP1 IQGAP3 JUN LIMK1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K11 MAPK14 MAPK8 MAPK9 NCF1 NCF2 NCKAP1 NOX1 NOXA1 NOXO1 PAK1 PAK2 PIP5K1A PIP5K1B PIP5K1C PLCB2 RAC1 RACGAP1 STAT3 STAT5A WASF1 WASF2 +PID_RAC1_REG_PATHWAY Regulation of RAC1 activity ABI1 ABR ARHGAP1 ARHGAP17 ARHGAP9 ARHGDIA ARHGEF2 ARHGEF25 ARHGEF6 ARHGEF7 BCR CHN1 CHN2 DEF6 DOCK1 DOCK2 DOCK6 ELMO1 EPS8 KALRN MCF2 NGEF PREX1 PREX2 RAC1 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 SOS1 SPATA13 TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 +PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression HDAC1 HDAC4 MDM2 PIAS1 PIAS2 RAN RANBP2 RANGAP1 SUMO1 UBE2I XPO1 +PID_RAS_PATHWAY Regulation of Ras family activation CAMK2B DAB2IP GRB2 HRAS KRAS LGALS1 LGALS3 NF1 NRAS PLCE1 PRKCA PRKCB PRKCE PRKCZ RABGEF1 RASA1 RASA2 RASA4 RASAL1 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RIN1 RRAS SOS1 SOS2 SYNGAP1 +PID_RB_1PATHWAY Regulation of retinoblastoma protein AATF ABL1 ATF2 ATF7 BGLAP BRD2 CBX4 CCNA2 CCND1 CCND2 CCND3 CCNE1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CEBPA CEBPB CEBPD CKM CREBBP CSF2 CTBP1 DNMT1 E2F1 E2F2 E2F3 E2F4 ELF1 EP300 GSC HDAC1 HDAC3 JUN MAPK11 MAPK14 MAPK9 MDM2 MEF2C MET MITF MYOD1 PAX3 PPARG PPP2CA PPP2R3B RAF1 RB1 RBBP4 RBP2 RUNX2 SFTPD SIRT1 SKP2 SMARCA4 SMARCB1 SPI1 SUV39H1 TAF1 TBP TFDP1 TGFB2 UBTF +PID_REELIN_PATHWAY Reelin signaling pathway AKT1 ARHGEF2 CBL CDK5 CDK5R1 CRKL DAB1 FYN GRIN2A GRIN2B GSK3B ITGA3 ITGB1 LRP8 LRPAP1 MAP1B MAP2K7 MAP3K11 MAPK8 MAPK8IP1 MAPT NCK2 PAFAH1B1 PIK3CA PIK3R1 RAP1A RAPGEF1 RELN VLDLR +PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network AFP AKT1 BAX BGLAP CDK5 CDK5R1 CDKN1A CGA CREB1 CREBBP CSF2 CSN2 EGR1 EP300 FGG FKBP4 FKBP5 FOS GATA3 GSK3B HDAC1 HDAC2 HSP90AA1 ICAM1 IFNG IL13 IL2 IL4 IL5 IL6 IL8 IRF1 JUN KRT14 KRT17 KRT5 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MDM2 MMP1 NCOA1 NCOA2 NFATC1 NFKB1 NR1I3 NR3C1 NR4A1 PBX1 PCK2 POMC POU1F1 POU2F1 PPP5C PRKACA PRKACB PRKACG PRL RELA SELE SFN SGK1 SMARCA4 SMARCC1 SMARCC2 SMARCD1 SPI1 STAT1 STAT5A STAT5B SUMO2 SUV420H1 TBP TBX21 TP53 TSG101 VIPR1 YWHAH +PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase BCAR1 CREB1 CRK DOK1 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 HRAS IRS1 IRS2 JUN MAPK1 MAPK3 MAPK8 NCK1 PDLIM7 PIK3CA PIK3R1 PRKACA PRKCA PTK2 PTPN11 PXN RAC1 RAP1A RASA1 RET RHOA SHANK3 SHC1 SOS1 SRC +PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling AKT1 CCNH CDK1 CDK7 CREBBP EP300 HDAC1 HDAC3 KAT2B MAPK1 MAPK14 MAPK3 MAPK8 MNAT1 NCOA1 NCOA2 NCOA3 NCOR2 NRIP1 PRKACA PRKCA PRKCG RARA RARB RARG RBP1 RXRA RXRB RXRG VDR +PID_RHOA_PATHWAY RhoA signaling pathway ACTA1 ATF2 CDC42 CDKN1B CFL1 CIT CYR61 DIAPH1 EZR F2RL2 FOS ITGB1 JUN LIMK1 LIMK2 MAP2K3 MAP2K4 MAP2K6 MAPK12 MAPK8 MKL1 MSN MYL2 PARD6A PIP5K1A PIP5K1B PIP5K1C PKN1 PKN2 PLD1 PLD2 PPP1R12A PRKCZ PTEN RDX RHOA ROCK1 ROCK2 SCAI SH3GL2 SLC9A1 SLC9A3 SRF TLN1 VCL +PID_RHOA_REG_PATHWAY Regulation of RhoA activity ABR AKAP13 ARAP1 ARAP3 ARHGAP35 ARHGAP4 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF5 BCR CDKN1B DEF6 DLC1 ECT2 FARP1 MCF2 MCF2L MYO9B NET1 NGEF OBSCN OPHN1 PLEKHG6 RGNEF RHOA SRGAP1 TRIO VAV1 VAV2 VAV3 +PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods CNGA1 CNGB1 GNAT1 GNB1 GNB5 GNGT1 GRK1 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F LRAT PDE6A PDE6B PDE6G RDH12 RDH5 RGS9 RGS9BP RHO RPE65 SAG SLC24A1 +PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor ABCA1 BCL2 FAM120B MED1 NCOA1 NCOR2 NR1H2 NR1H3 NR1H4 NR4A1 PPARA PPARD PPARG RARA RARB RARG RPS6KB1 RXRA RXRB RXRG SREBF1 TGFB1 THRA THRB TNF VDR +PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway ABCC1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SGPL1 SGPP1 SPHK1 SPHK2 +PID_S1P_S1P1_PATHWAY S1P1 pathway ABCC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ ITGAV ITGB3 KDR MAPK1 MAPK3 PDGFB PDGFRB PLCB2 PLCG1 PTGS2 RAC1 RHOA S1PR1 SPHK1 VEGFA +PID_S1P_S1P2_PATHWAY S1P2 pathway CDH5 ELK1 FOS GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ IRS1 JUN MAPK1 MAPK14 MAPK3 MAPK8 PAK1 RAC1 RHOA S1PR2 +PID_S1P_S1P3_PATHWAY S1P3 pathway AKT1 AKT3 CXCR4 FLT1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ ITGAV ITGB3 JAK2 MAPK1 MAPK3 PDGFB PDGFRB RAC1 RHOA S1PR1 S1PR2 S1PR3 SRC VEGFA +PID_S1P_S1P4_PATHWAY S1P4 pathway CDC42 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ MAPK1 MAPK3 PLCG1 RHOA S1PR4 S1PR5 +PID_SHP2_PATHWAY SHP2 signaling ANGPT1 ARHGAP35 BDNF EGF EGFR FRS2 FRS3 GAB1 GAB2 GNAI1 GNAI3 GRB2 HRAS IFNG IFNGR1 IGF1 IGF1R IL2 IL2RA IL2RB IL2RG IL6 IL6R IL6ST IRS1 JAK1 JAK2 JAK3 KDR KRAS LCK LMO4 MAP2K1 MAP2K2 MLLT4 NGF NOS3 NRAS NTF3 NTF4 NTRK1 NTRK2 NTRK3 PAG1 PDGFB PDGFRB PIK3CA PIK3R1 PRKACA PTPN11 RAF1 RHOA SDC2 SHC1 SOS1 STAT1 TEK VEGFA +PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling AKT1 AR ATF2 ATF3 CBFB CDK2 CDK4 CDKN1A CDKN2B CEBPB CITED1 COL1A2 CREB1 CREBBP CTBP1 DCP1A DLX1 E2F4 E2F5 EP300 ESR1 FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GATA3 GSC HDAC1 HDAC2 HNF4A HSPA8 IFNB1 IGHA1 IL10 IL5 IRF7 ITGB5 JUN KAT2A KAT2B LAMC1 MAX MED15 MEF2C MYC MYOD1 NCOA1 NCOA2 NCOR1 NKX2-5 NR3C1 PIAS3 PIAS4 RBBP4 RBBP7 RBL1 RUNX1 RUNX2 RUNX3 SAP18 SAP30 SERPINE1 SIN3A SIN3B SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SP1 SP3 TCF3 TFDP1 TFE3 TGIF1 TGIF2 VDR ZBTB17 +PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling CTDSP1 CTDSP2 CTDSPL KPNA2 KPNB1 MAP3K1 MAPK1 MAPK3 NUP153 NUP214 PIAS4 PPM1A SMAD2 SMAD3 SMAD4 TGFBRAP1 UBE2I +PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events BSG CASK CCL5 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 HGF HPSE LAMA5 MAPK1 MAPK3 MET MMP1 MMP7 MMP9 PPIB PRKACA SDC1 SDCBP TGFB1 +PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events BAX CASK CASP3 CAV2 CSF2 EPB41 EPHB2 EZR FN1 GNB2L1 HRAS IL8 ITGA2 ITGA5 ITGB1 KNG1 LAMA1 LAMA3 MAPK1 MAPK3 MAPK8 MMP2 NF1 PRKACA PRKCD RASA1 RHOA SDC2 SDCBP SRC TGFB1 TNFRSF13B TRAPPC4 +PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events AGRP APH1A APH1B CASK CTTN EGFR FYN IL8 MC4R NCAN NCSTN POMC PSEN1 PSENEN PTN SDC3 SRC +PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events ACTN1 ADAM12 CCL5 CXCL12 CXCR4 DNM2 F2 FGF2 FGF6 FGFR1 FN1 FZD7 GIPC1 ITGA5 ITGB1 LAMA1 LAMA3 MDK MMP9 NUDT16L1 PLG PRKCA PRKCD PTK2 RAC1 RHOA SDC4 SDCBP TFPI THBS1 TNC TNFRSF13B +PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms ABL1 ADA AEN BAX BBC3 CABLES1 CDKN1A CDKN2A CHUK CLCA2 DHRS3 DICER1 DST EGR2 EP300 EVPL FAS FDXR FLOT2 GADD45A GDF15 GPX2 HBP1 IGFBP3 IKBKB ITCH ITGA3 ITGB4 JAG1 MDM2 MFGE8 NOC2L NQO1 OGG1 PERP PLK1 PMAIP1 PML PRKCD S100A2 SERPINB5 SHH SMARCD3 SP1 SPATA18 SSPO SSRP1 TFAP2C TP53I3 TP63 TRAF4 VDR WWP1 YWHAQ +PID_TCPTP_PATHWAY Signaling events mediated by TCPTP ATR CREBBP CSF1 CSF1R EGF EGFR EIF2A EIF2AK2 GAB1 GRB2 HGF INS INSR ITGA1 ITGB1 JAK1 JAK3 KDR KPNA2 KPNB1 LMAN1 MET PDGFB PDGFRB PIAS1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN1 PTPN2 RAB4A SHC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 VEGFA +PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway AKAP5 BATF3 CABIN1 CD40LG CHP CREM CSF2 FASLG FKBP1A FOS FOSL1 IFNG IL2 IL2RA IL3 IL4 JUN JUNB NFATC1 NFATC2 NFATC3 POU2F1 PPP3CA PPP3CB PPP3R1 PRKACA PTGS2 RCAN1 RCAN2 +PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway CRK CRKL DBNL GRAP2 JUN LAT LCP2 MAP2K4 MAP3K1 MAP3K7 MAP3K8 MAP4K1 MAPK8 PRKCB +PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells AKT1 BCL10 CARD11 CBL CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDC42 CHUK CSK DBNL FLNA FYB FYN GAB2 GRAP2 GRB2 HLA-DRA HLA-DRB1 HRAS IKBKB IKBKG INPP5D ITK KRAS LAT LCK LCP2 MALT1 MAP3K14 MAP3K8 MAP4K1 NCK1 NRAS ORAI1 PAG1 PDPK1 PLCG1 PRKCA PRKCB PRKCE PRKCQ PTEN PTPN11 PTPN6 PTPRC RAP1A RASGRP1 RASGRP2 RASSF5 SH3BP2 SHC1 SLA2 SOS1 STIM1 STK39 TRAF6 TRPV6 VAV1 WAS ZAP70 +PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway BRAF ELK1 FOS HRAS KRAS MAP2K1 MAP3K8 MAPK1 MAPK3 NRAS PRKCA PRKCB PTPN7 RAF1 +PID_TELOMERASE_PATHWAY Regulation of Telomerase ABL1 ACD AKT1 ATM BLM CCND1 CDKN1B DKC1 E2F1 EGF EGFR ESR1 FOS HDAC1 HDAC2 HNRNPC HSP90AA1 HUS1 IFNAR2 IFNG IL2 IRF1 JUN MAPK1 MAPK3 MAX MRE11A MTOR MXD1 MYC NBN NCL NFKB1 NR2F2 PARP2 PIF1 PINX1 POT1 PTGES3 RAD1 RAD50 RAD9A RBBP4 RBBP7 RPS6KB1 SAP18 SAP30 SIN3A SIN3B SMAD3 SMG5 SMG6 SP1 SP3 TERF1 TERF2 TERF2IP TERT TGFB1 TINF2 TNKS UBE3A WRN WT1 XRCC5 XRCC6 YWHAE ZNFX1 +PID_TGFBR_PATHWAY TGF-beta receptor signaling ARRB2 AXIN1 BAMBI CAMK2A CAV1 CTGF CTNNB1 DAB2 DACT2 DAXX DYNLRB1 EIF2A FKBP1A GRB2 ITCH MAP3K7 NEDD4L OCLN PARD6A PDPK1 PML PPP1CA PPP1R15A PPP2CA PPP2CB PPP2R2A RHOA RNF111 RPS6KB1 SHC1 SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SOS1 SPTBN1 STRAP TAB1 TAB2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TGFBRAP1 WWP1 XIAP YAP1 YWHAE ZFYVE16 ZFYVE9 +PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events ADRBK2 AKAP13 ARHGDIA ARHGEF1 ARRB1 DNM1 DNM2 F2 F2R F2RL2 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ GNB1 GNG2 MYL2 NOS3 PIK3CA PIK3R1 PKN1 PLCB1 PLCB2 PLCB3 PRKCA PRKCB PRKCD PRKCG RHOA ROCK1 ROCK2 SNX1 SNX2 TRPC6 VASP ZYX +PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events F2 F2RL2 F2RL3 GNA11 GNA13 GNA14 GNA15 GNAQ GNB1 GNG2 MYL2 PLCB2 RHOA ROCK1 ROCK2 +PID_TNF_PATHWAY TNF receptor signaling pathway ADAM17 BAG4 BIRC2 BIRC3 CASP8 CAV1 CHUK CYLD FADD GNB2L1 IKBKB IKBKG MADD MAP2K3 MAP2K7 MAP3K1 MAP3K3 MAP3K5 MAP3K7 MAP4K2 MAP4K3 MAP4K4 MAP4K5 NFKB1 NRK NSMAF PRKCI PRKCZ RELA RFFL RIPK1 SMPD1 SMPD2 SQSTM1 STAT1 TAB1 TAB2 TNF TNFAIP3 TNFRSF1A TNFRSF1B TNIK TRADD TRAF1 TRAF2 TXN +PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling BGN CD14 CHUK HMGB1 HSPD1 IKBKB IKBKG IRAK1 IRAK2 IRAK4 LY96 MYD88 RHOA S100A8 S100A9 SAA1 SFTPA1 TICAM1 TIRAP TLR1 TLR2 TLR3 TLR4 TLR6 VCAN +PID_TRAIL_PATHWAY TRAIL signaling pathway CASP10 CASP8 CFLAR CHUK DAP3 FADD IKBKB IKBKG MAP2K4 MAP3K1 MAPK1 MAPK3 MAPK8 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RIPK1 SMPD1 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFSF10 TRADD TRAF2 +PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling ABL1 ARHGAP32 BDNF CCND1 CDC42 CRK CRKL DNAJA3 DNM1 DOCK1 DYNLT1 EHD4 ELMO1 FAIM FRS2 FRS3 GAB1 GAB2 GIPC1 GRB2 HRAS KRAS MAGED1 MAP2K1 MAPK1 MAPK3 MATK MCF2L NEDD4L NGF NGFR NRAS NTF3 NTF4 NTRK1 NTRK2 NTRK3 PIK3CA PIK3R1 PLCG1 PRKCI PRKCZ PTPN11 RAC1 RAP1A RAP1B RAPGEF1 RASA1 RASGRF1 RGS19 RHOA RHOG RIT1 RIT2 SH2B1 SHC1 SHC2 SHC3 SOS1 SQSTM1 STAT3 TIAM1 +PID_TXA2PATHWAY Thromboxane A2 receptor signaling ADRBK1 ADRBK2 AKT1 ARHGEF1 ARR3 ARRB2 BLK DNM1 EGF EGFR FGR FYN GNA11 GNA12 GNA13 GNA14 GNA15 GNAI2 GNAQ GNB1 GNB5 GNG2 HCK ICAM1 LCK LYN MAPK11 MAPK14 NOS3 PIK3CG PIK3R5 PIK3R6 PLCB2 PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ PRKG1 PTGDR PTGIR RAB11A RAC1 RHOA ROCK1 SELE SLC9A3R1 SRC SYK TBXA2R TGM2 VCAM1 YES1 +PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling BCAR1 CRK CTRC CTSG DOCK1 EGFR ELANE FGA FGB FGG FN1 FPR1 FPR2 FPR3 GPLD1 HGF ITGA3 ITGA5 ITGAM ITGAV ITGB1 ITGB2 ITGB3 ITGB5 KLK4 LRP1 MMP12 MMP13 MMP3 MMP9 NCL PDGFD PDGFRB PLAU PLAUR PLG RAC1 SERPINE1 SRC TGFB1 VLDLR VTN +PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network FIGF FLT1 FLT4 KDR NRP1 NRP2 PGF VEGFA VEGFB VEGFC +PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2 AKAP1 AKT1 ARF1 BRAF CAMKK2 CAV1 CBL CDC42 CDH5 CTNNA1 CTNNB1 DNM2 FBXW11 FES FLT1 FYN GAB1 GRB10 GRB2 HGS HSP90AA1 HSP90AB1 IQGAP1 ITGAV ITGB3 KDR MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK11 MAPK14 MAPK3 MAPKAPK2 MYOF NCK1 NCK2 NEDD4 NOS3 PAK2 PDPK1 PIK3CA PIK3R1 PLCG1 PRKAA1 PRKAA2 PRKAB1 PRKACA PRKAG1 PRKCA PRKCB PRKCD PTK2 PTK2B PTPN11 PTPN2 PTPN6 PTPRJ PXN RAF1 RHOA ROCK1 SH2D2A SHB SRC VCL VEGFA VTN +PID_VEGFR1_PATHWAY VEGFR1 specific signals AKT1 CAV1 CBL CD2AP FLT1 HIF1A HSP90AA1 MAPK1 MAPK3 NCK1 NOS3 NRP1 NRP2 PDPK1 PGF PIK3CA PIK3R1 PLCG1 PRKACA PRKCA PRKCB PTPN11 RASA1 SHC2 VEGFA VEGFB +PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway APC AXIN1 CAV1 CSNK1G1 CTNNB1 CUL3 DVL1 DVL2 DVL3 FZD5 GSK3A GSK3B KLHL12 LRP6 NKD2 PI4K2A PIP5K1B PPP2R5A RANBP3 WNT3A +PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway ARRB2 CAMK2A CDC42 CHD7 CSNK1A1 CTHRC1 DAAM1 DVL1 DVL2 DVL3 FLNA FZD2 FZD5 FZD6 FZD7 MAP3K7 MAPK10 MAPK8 MAPK9 NFATC2 NLK PPARG PRKCZ RAC1 RHOA ROCK1 ROR2 SETDB1 TAB1 TAB2 WNT5A YES1 +PID_WNT_SIGNALING_PATHWAY Wnt signaling network ATP6AP2 CTHRC1 DKK1 FZD1 FZD10 FZD2 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 IGFBP4 KREMEN1 KREMEN2 LRP5 LRP6 ROR2 RSPO1 RYK WIF1 WNT1 WNT2 WNT3 WNT3A WNT5A WNT7A WNT7B +REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3FP3 EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H FAM153A FAU LOC641895 LOC646184 LOC647074 LOC649602 LOC651825 LOC651894 LOC652607 LOC653881 LOC653994 LOC730343 PABPC1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 UBA52 +REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GXYLT1 GXYLT2 HSPG2 NCAN SDC1 SDC2 SDC3 SDC4 VCAN +REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism ABCB1 ABCG2 ADAL ADH1A GUK1 NT5C2 PCK1 SLC22A1 SLC22A2 SLC22A3 +REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport ABCA10 ABCA12 ABCA2 ABCA3 ABCA4 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB5 ABCB6 ABCC1 ABCC11 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 ABCD1P5 ABCD2 ABCD3 ABCG1 ABCG4 ABCG5 ABCG8 APOA1 CFTR PEX19 PEX3 +REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis ABCA10 ABCA12 ABCA2 ABCA3 ABCA6 ABCA7 ABCA9 ABCD1 ABCD1P5 ABCD2 ABCD3 ABCG1 ABCG4 ABCG5 ABCG8 APOA1 PEX19 PEX3 +REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat COBRA1 CTDP1 GTF2F1 GTF2F2 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RDBP SUPT4H1 SUPT5H TH1L WHSC2 +REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG LOC732445 +REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle CHAT RAB3A RIMS1 SLC18A3 SLC5A7 SNAP25 STX1A STXBP1 SYT1 VAMP2 +REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle ACACB ACSL1 CAB39 CAB39L CPT1A CPT1B CPT2 LOC644462 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 SLC25A20 STK11 STRADA STRADB +REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CNTN1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 JAG1 JAG2 MIB1 MIB2 NCSTN NEURL NUMB PSEN1 PSEN2 PSENEN RPS27A RPS27AP11 UBA52 +REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2 FGF1 FGF10 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 +REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation IKBKG IRAK1 IRAK2 LOC650832 MAP2K3 MAP2K6 MAP3K7 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TRAF6 +REACTOME_ACTIVATED_TLR4_SIGNALLING Genes involved in Activated TLR4 signalling AGER APP ATF1 ATF2 BTK CD14 CDK1 CHUK CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 JUN LOC650832 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK1 RIPK2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR TAB1 TAB2 TAB3 TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR2 TLR3 TLR4 TLR6 TMEM189-UBE2V1 TRAF3 TRAF6 UBA52 UBE2N +REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress ATR ATRIP CDC25A CDC25C CDC45 CDC6 CDC7 CDK2 CHEK1 DBF4 HUS1 LOC645084 LOC648152 LOC651921 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RAD1 RAD17 RAD9A RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins AKT1 BAD BBC3 BCL2 BCL2L11 BID BMF DYNLL1 DYNLL2 E2F1 LOC441488 MAPK8 PMAIP1 PPP3R1 TFDP1 TP53 YWHAB +REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha ATF4 ATF4P3 ATF6 CALR DDIT3 HSP90B1 HSPA5 LOC730136 NFYA NFYB XBP1 +REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S) ACADVL ADD1 ARFGAP1 ATP6V0D1 C19orf10 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DDX12P DNAJB11 DNAJB9 DNAJC3 EDEM1 EXTL3 FKBP14 GOSR2 GSK3A HDGF HYOU1 KDELR3 KLHDC3 LMNA PDIA5 PDIA6 PPP2R5B PREB SEC31A SERP1 SHC1 SRPR SRPRB SSR1 SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha ATF4 ATF4P3 ATF6 CALR DDIT3 HSP90B1 HSPA5 LOC730136 MBTPS1 MBTPS2 NFYA NFYB XBP1 +REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4 ASNS ATF3 ATF4 ATF4P3 ATF6 CCL2 DCP2 DDIT3 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 IGFBP1 IL8 KHSRP LOC730136 NFYA NFYB PARN +REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon CD14 IKBKE IRF3 IRF7 LY96 RPS27A RPS27AP11 TBK1 TICAM1 TICAM2 TLR3 TLR4 TRAF3 UBA52 +REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding CALM1 CALM2 CALM3 DLG1 DLG3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD PLCB1 PLCB2 PLCB3 +REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells BCL10 BTRC CARD11 CHUK CUL1 FBXW11 IKBKB IKBKG LOC646626 LOC652826 MALT1 MAP3K7 NFKBIA NFKBIB NFKBIE PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 REL RELA RPS27A RPS27AP11 SKP1 UBA52 +REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events ACTN2 ADCY1 ADCY3 ADCY8 AKAP9 BRAF CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK4 CAMKK1 CREB1 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 PRKACB RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac GPC1 LOC729030 NCK1 NCK2 PAK1 PAK2 PAK4 PAK6 PAK7 RAC1 ROBO1 SLIT2 SOS1 SOS2 +REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors ATF2 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 +REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3FP3 EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H FAU LOC651894 LOC652607 LOC653994 PABPC1 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 +REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 LOC645084 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 RPA1 RPA2 RPA3 RPA4 +REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC LPCAT1 LPCAT2 LPCAT3 LPCAT4 MBOAT2 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLA2G6 PLBD1 PNPLA8 +REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE LPCAT3 LPCAT4 MBOAT1 MBOAT2 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLA2G6 PLBD1 PNPLA8 +REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG CRLS1 LPCAT1 LPCAT4 LPGAT1 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4D PLA2G4F PLA2G5 +REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI MBOAT7 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLBD1 +REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS LPCAT3 LPCAT4 MBOAT1 PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4D PLA2G4F PLA2G5 +REACTOME_ADAPTIVE_IMMUNE_SYSTEM Genes involved in Adaptive Immune System ACTR1A ACTR1B AKT1 AKT1S1 AKT2 AKT3 AMICA1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ARIH2 ASB1 ASB11 ASB12 ASB13 ASB15 ASB16 ASB17 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 B2M BAD BCL10 BLK BLMH BLNK BTK BTLA BTRC C3 CALM1 CALM2 CALM3 CALR CANX CARD11 CASP9 CBL CBLB CD160 CD19 CD200R1 CD207 CD226 CD247 CD274 CD28 CD34 CD36 CD3D CD3E CD3G CD4 CD40 CD40LG CD74 CD79A CD79B CD80 CD81 CD86 CD8A CD8B CD96 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDC34 CDC42 CDH1 CDKN1A CDKN1B CHUK CLTA CLTC CREB1 CRTAM CSK CTLA4 CTSA CTSB CTSC CTSD CTSF CTSH CTSK CTSL1 CTSL2 CTSO CTSS CUL1 CUL2 CUL3 CUL5 CUL7 CXADR CYBA CYBB DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DET1 DNM1 DNM2 DTX3L DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DZIP3 ENAH ERAP1 EVL FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCGR1A FCGR1B FCGR2B FCGR3A FOXO1 FOXO3 FOXO4 FYB FYN GAN GRAP2 GRB2 GSK3A HCST HECTD3 HERC2 HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 HLA-F HLA-G HLA-K HRAS HSPA5 HUWE1 ICAM1 ICAM2 ICAM3 ICAM4 ICOS ICOSLG IFITM1 IKBKB IKBKG ITGAL ITGAV ITGB1 ITGB2 ITGB5 ITGB7 ITK ITPR2 ITPR3 KEAP1 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIFAP3 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR3DL1 KIR3DL2 KLC1 KLC2 KLC3 KLC4 KLHL13 KLHL20 KLHL9 KLRC1 KLRD1 KLRK1 KRAS LAT LCK LCP2 LGMN LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LNPEP LOC644006 LOC646626 LOC647654 LOC648998 LOC649620 LOC650621 LOC651536 LOC651763 LOC652578 LOC652626 LOC652826 LOC653879 LOC729120 LOC730418 LOC730594 LOC731049 LOC731066 LOC731292 LOC731429 LRR1 LRRC41 LRSAM1 LYN MALT1 MAP3K14 MAP3K7 MAP3K8 MAPKAP1 MDM2 MKRN1 MLST8 MRC1 MRC2 MTOR NCF2 NCF4 NCK1 NEDD4 NFKBIA NFKBIB NFKBIE NPEPPS NR4A1 NRAS ORAI1 OSBPL1A PAG1 PAK1 PAK2 PARK2 PDCD1 PDCD1LG2 PDIA3 PDPK1 PHLPP1 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PJA1 PJA2 PLCG1 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKACA PRKACB PRKACG PRKCB PRKCQ PRKG1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTEN PTPN6 PTPRC PVR PVRL2 RAB7A RAC1 RACGAP1 RAET1E RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RASGRP3 RBCK1 RBX1 RCHY1 REL RELA RICTOR RILP RIPK2 RNF123 RNF138 RNF144B RNF182 RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS27AP11 RPS6KB2 SAE1 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SELL SH3GL2 SH3KBP1 SHC1 SIPA1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SOS1 SPSB1 SPSB2 SPSB4 SPTBN2 SRC STIM1 STUB1 SYK TAB2 TAP1 TAP2 TCEB1 TCEB1P3 TCEB2 THEM4 TMEM189-UBE2V1 TNFRSF14 TPP2 TRAF6 TRAT1 TRIB3 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 TSC2 TYROBP UBA1 UBA2 UBA3 UBA5 UBA52 UBA6 UBA7 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2HP1 UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 ULBP1 ULBP2 ULBP3 VASP VAV1 VCAM1 VHL VPRBP WAS WSB1 WWP1 YES1 YWHAB YWHAZ ZAP70 ZBTB16 +REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAL +REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAI1 GNAI2 GNAI3 GNAL +REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions CADM1 CADM2 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CTNNA1 CTNNB1 CTNND1 JUP PVR PVRL1 PVRL2 PVRL3 PVRL4 +REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1 GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK14 P2RY1 PLA2G4A SRC +REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12 GNAI1 GNAI2 GNAI3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 P2RY12 +REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling AGER APP CAPZA1 CAPZA2 DDOST HMGB1 LGALS3 MAPK1 MAPK3 PRKCSH S100A12 S100B SAA1 +REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK GSK3A MDM2 TSC2 +REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism ABCD1 ABCD1P5 ACAA1 ACOT8 ACOX1 ACSL1 ELOVL2 ELOVL5 FADS1 FADS2 HSD17B4 SCP2 +REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters RHAG RHCG SLC14A1 SLC14A2 SLC18A1 SLC18A2 SLC22A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones AANAT CGA DBH DDC DIO1 DIO2 DIO3 IYD PNMT SLC5A5 TH TPH1 TPH2 TPO TSHB +REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM5 DRD1 DRD2 DRD3 DRD5 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 LOC730413 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 +REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A10 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC25A10 SLC32A1 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC5A5 SLC5A8 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 +REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination) ALDH18A1 ASNS CCBL1 GLS GLS2 GLUD1 GLUL GOT1 GOT2 GPT GPT2 LOC643554 OAT PHGDH PSAT1 PSPH PYCR1 +REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane SLC16A10 SLC1A4 SLC1A5 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 +REACTOME_AMYLOIDS Genes involved in Amyloids APCS APOA1 APP B2M CALCA CST3 FGA GSN H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HSPG2 IAPP INS ITM2B LOC728320 LOC731820 LTF LYZ MFGE8 NPPA ODAM PRL SAA1 SEMG1 SNCA TGFBI TTR +REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis CGA CYP17A1 HSD17B3 HSD3B1 HSD3B2 LHB POMC SRD5A1 SRD5A2 SRD5A3 +REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers BLK BLNK BTK CALM1 CALM2 CALM3 CBL CBLB CD19 CD79A CD79B FYN GRB2 ITPR2 ITPR3 LYN NCK1 ORAI1 PIK3AP1 PIK3CD PIK3R1 PLCG1 PLCG2 SH3KBP1 SHC1 SOS1 STIM1 SYK VAV1 +REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC B2M CALR CANX ERAP1 HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K HSPA5 PDIA3 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A TAP1 TAP2 +REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation B2M CALR CD207 CD36 CTSS CYBA CYBB FCGR1A FCGR1B HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K ITGAV ITGB5 LNPEP LOC648998 LOC652826 MRC1 MRC2 NCF2 NCF4 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 SEC61A1 SEC61A2 SEC61B SEC61G TAP1 TAP2 UBA52 +REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ARIH2 ASB1 ASB11 ASB12 ASB13 ASB15 ASB16 ASB17 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 BLMH BTRC CBLB CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDC34 CUL1 CUL2 CUL3 CUL5 CUL7 DET1 DTX3L DZIP3 FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 GAN HECTD3 HERC2 HUWE1 KEAP1 KLHL13 KLHL20 KLHL9 LNPEP LOC644006 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 LOC731049 LOC731429 LRR1 LRRC41 LRSAM1 MKRN1 NEDD4 NPEPPS PARK2 PJA1 PJA2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBCK1 RBX1 RCHY1 RNF123 RNF138 RNF144B RNF182 RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS27AP11 SAE1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SPSB1 SPSB2 SPSB4 STUB1 TCEB1 TCEB1P3 TCEB2 TMEM189-UBE2V1 TPP2 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 UBA1 UBA2 UBA3 UBA5 UBA52 UBA6 UBA7 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2HP1 UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 VHL VPRBP WSB1 WWP1 ZBTB16 +REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes AAAS ARIH1 DDX58 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FLNB HERC5 IFIT1 IRF3 ISG15 JAK1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNB1 MAPK3 MX1 MX2 NEDD4 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PIN1 PLCG1 POM121 PPM1B RAE1 RANBP2 RPS27A RPS27AP11 SEH1L STAT1 TPR TRIM25 UBA52 UBA7 UBE2E1 UBE2L6 UBE2N USP18 +REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDK1 LOC647654 LOC649620 LOC650621 LOC651763 LOC730594 RPS27A RPS27AP11 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDK1 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 MAD2L1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTTG1 RPS27A RPS27AP11 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTTG1 RPS27A RPS27AP11 SKP2 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 LOC647654 LOC649620 LOC650621 LOC651763 LOC730594 MAD2L1 NEK2 RPS27A RPS27AP11 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection APOBEC3G BANF1 HMGA1 LOC128192 LOC131691 LOC643997 LOC645870 LOC654188 PPIA PPIAP22 PPIAP8 PSIP1 +REACTOME_APOPTOSIS Genes involved in Apoptosis ACIN1 ADD1 AKT1 APAF1 APC APPL1 ARHGAP10 BAD BAK1 BAX BBC3 BCAP31 BCL2 BCL2L1 BCL2L11 BID BIRC2 BMF BMX CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CDH1 CFLAR CTNNB1 CYCS DAPK1 DAPK2 DAPK3 DBNL DCC DFFA DFFB DIABLO DNM1L DSG1 DSG2 DSG3 DSP DYNLL1 DYNLL2 E2F1 FADD FAS FASLG FNTA GAS2 GSN GZMB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 LMNA LMNB1 LOC441488 LOC647859 LOC652460 LOC652826 MAGED1 MAPK8 MAPT MST4 NMT1 OCLN PAK2 PKP1 PLEC PMAIP1 PPP3R1 PRKCD PRKCQ PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTK2 RIPK1 ROCK1 ROCK1P1 RPS27A RPS27AP11 SATB1 SPTAN1 STK24 TFDP1 TJP1 TJP2 TNF TNFRSF10B TNFRSF1A TNFSF10 TP53 TRADD TRAF2 UBA52 UNC5A UNC5B VIM XIAP YWHAB +REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation CASP3 DFFA DFFB H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 +REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins CASP3 CDH1 CTNNB1 DSG1 DSG2 DSG3 DSP LOC647859 OCLN PKP1 TJP1 TJP2 +REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins ACIN1 ADD1 APC BCAP31 BIRC2 BMX CASP3 CASP6 CASP7 CASP8 CDH1 CTNNB1 DBNL DSG1 DSG2 DSG3 DSP FNTA GAS2 GSN LMNA LMNB1 LOC647859 LOC652460 MAPT MST4 OCLN PKP1 PLEC PRKCD PRKCQ PTK2 ROCK1 ROCK1P1 SATB1 SPTAN1 STK24 TJP1 TJP2 VIM +REACTOME_APOPTOTIC_EXECUTION_PHASE Genes involved in Apoptotic execution phase ACIN1 ADD1 APC BCAP31 BIRC2 BMX CASP3 CASP6 CASP7 CASP8 CDH1 CTNNB1 DBNL DFFA DFFB DNM1L DSG1 DSG2 DSG3 DSP FNTA GAS2 GSN H1F0 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGB1 HMGB2 KPNA1 KPNB1 LMNA LMNB1 LOC647859 LOC652460 MAPT MST4 OCLN PAK2 PKP1 PLEC PRKCD PRKCQ PTK2 ROCK1 ROCK1P1 SATB1 SPTAN1 STK24 TJP1 TJP2 VIM +REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP10 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 LOC730418 MIP MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 +REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation BRAF CDK1 CRK HRAS KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 RAF1 RAP1A RAPGEF1 YWHAB +REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CALR CANX DAD1 DDOST DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 FUT8 GANAB GFPT2 GMPPA GMPPB GNPNAT1 LMAN1 LOC285407 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPI PDIA3 PGM3 PMM1 PMM2 PREB PRKCSH RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 STT3A TUSC3 UGGT1 UGGT2 +REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Assembly of the pre-replicative complex CDC6 CDT1 E2F1 E2F2 E2F3 GMNN LOC652826 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 +REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex CDC6 CDT1 E2F1 E2F2 E2F3 GMNN ORC1 ORC2 ORC3 ORC4 ORC5 RPS27A RPS27AP11 UBA52 +REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis AP3M1 ARFGEF2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 FBXL3 FBXL5 FBXO4 FBXO6 FBXW2 FBXW4 FBXW5 FBXW7 FKBP9 KIF13A KIFC3 LOC732391 LONP2 NOP56 SPHK1 TCP1 USP11 XRN2 +REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC23 CDC26 CDC26P1 CDC27 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RPS27A RPS27AP11 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 ATM LOC651610 LOC652826 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RFWD2 RFWD2P1 RPS27A RPS27AP11 TP53 UBA52 +REACTOME_AXON_GUIDANCE Genes involved in Axon guidance ABL1 ABL2 ABLIM1 ABLIM3 AGRN ALCAM ANK1 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGAP35 ARHGEF11 ARHGEF12 ARTN CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CAP1 CAP2 CD24 CD72 CDC42 CDK1 CDK5 CDK5R1 CFL1 CLASP1 CLTA CLTC CNTN1 CNTN2 CNTN6 CNTNAP1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 CREB1 CRMP1 CSNK2A1 CSNK2A2 CSNK2B DCC DCX DLG1 DLG3 DNM1 DNM2 DOCK1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 EGFR ENAH ERBB2 EVL EZR FARP2 FES FGFR1 FYN GDNF GFRA1 GFRA2 GFRA4 GPC1 GRB2 HFE2 HRAS HSP90AA1 HSP90AB1 ITGA1 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 KCNQ2 KCNQ3 KIAA1598 KIF4A KIF4B KRAS L1CAM LAMA1 LAMB1 LAMC1 LIMK1 LIMK2 LOC642076 LOC644816 LOC650400 LOC729030 LOC730030 LOC730221 LOC730335 LOC731231 MAP2K1 MAP2K2 MAPK1 MAPK3 MET MSN MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL8P MYL9 MYO10 NCAM1 NCAN NCK1 NCK2 NEO1 NRAS NRCAM NRP1 NRP2 NRTN NTN1 NTN4 NUMB PAK1 PAK2 PAK4 PAK6 PAK7 PFN1 PFN2 PIP5K1C PITPNA PLCG1 PLXNA1 PLXNA2 PLXNA3 PLXNB1 PLXNB3 PLXNC1 PLXND1 PRKCQ PRNP PSPN PTK2 PTPRC RAC1 RAC2 RAF1 RANBP9 RDX RGMA RGMB RHOA RHOB RHOC RHOG RND1 ROBO1 ROBO2 ROBO3 ROCK1 ROCK1P1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS SCN1B SCN2A SCN2B SCN3B SCN4A SCN5A SCN7A SCN8A SDCBP SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A SH3GL2 SIAH1 SIAH2 SLIT1 SLIT2 SLIT3 SOS1 SOS2 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC SRGAP1 SRGAP2 SRGAP3 ST8SIA2 ST8SIA4 STIP1 TLN1 TREM2 TRIO TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TYROBP UNC5A UNC5B UNC5C UNC5D VASP WASL YWHAB +REACTOME_BASE_EXCISION_REPAIR Genes involved in Base Excision Repair APEX1 CCNO FEN1 LIG1 LIG3 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG XRCC1 +REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway APEX1 CCNO MBD4 MPG MUTYH NTHL1 OGG1 POLB SMUG1 TDG +REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions ATP1B1 ATP1B2 ATP1B3 BSG CAV1 ITGA3 ITGB1 L1CAM LOC128192 LOC131691 LOC643997 LOC654188 MAG MMP1 PPIA PPIAP22 PPIAP8 PPIL2 SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SPN +REACTOME_BETA_DEFENSINS Genes involved in Beta defensins CCR2 CCR6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B LOC729523 LOC731949 TLR1 TLR2 +REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM Genes involved in Bile acid and bile salt metabolism ABCB11 ABCC3 ACOT8 ACOX2 AKR1C4 AKR1D1 ALB AMACR BAAT CH25H CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 FABP6 HSD17B4 HSD3B7 SCP2 SLC10A1 SLC10A2 SLC27A2 SLC27A5 SLCO1A2 SLCO1B1 SLCO1B3 +REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters SLC10A6 SLC13A1 SLC13A2 SLC13A3 SLC13A5 SLC16A1 SLC16A3 SLC16A7 SLC16A8 SLC47A1 SLC47A2 +REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion CCR5 CD4 CXCR4 LOC128192 LOC131691 LOC643997 LOC654188 PPIA PPIAP22 PPIAP8 +REACTOME_BIOLOGICAL_OXIDATIONS Genes involved in Biological oxidations ACSM1 ACSM2B ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 AHCY ALDH1A1 ALDH2 BPNT1 CNDP2 COMT CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FMO1 FMO2 FMO3 GCLC GCLM GGCT GGT1 GGT5 GGT7 GLYAT GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 LOC648338 LOC731992 MAOA MAOB MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR NAT1 NAT2 NNMT OPLAH PAOX PAPSS1 PAPSS2 POMC PTGIS PTGS1 PTGS2 SLC35D1 SMOX SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TBXAS1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 GFPT2 GMPPA GMPPB GNPNAT1 LOC285407 MPI PGM3 PMM1 PMM2 RFT1 +REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression ARNTL ARNTL2 AVP BHLHE40 BHLHE41 CCRN4L CLOCK CREBBP CRY1 CRY2 DBP EP300 F7 HDAC3 MED1 NAMPT NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NPAS2 NR1D1 NR3C1 PER1 PER2 PPARA PPARGC1A PRIC285 RORA RXRA SERPINE1 SMARCD3 TBL1X TBL1XR1 TGS1 +REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity LOC642105 SNAP25 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 SYT1 SYT2 VAMP1 VAMP2 +REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism ACAD8 ACADSB ACAT1 ALDH6A1 AUH BCAT1 BCAT2 BCKDHA BCKDHB DBT DLD HIBADH HIBCH HSD17B10 IVD MCCC1 MCCC2 +REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CALM2 CALM3 CAMK4 CREB1 LOC730418 MAPK1 PDE1A PDE1B PLA2G4A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle CALR CANX EDEM1 EDEM2 EDEM3 GANAB MAN1B1 PDIA3 PRKCSH UGGT1 UGGT2 +REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins ADD1 CASP3 CASP6 CASP7 CASP8 DBNL GAS2 GSN LOC652460 MAPT PLEC SPTAN1 VIM +REACTOME_CD28_CO_STIMULATION Genes involved in CD28 co-stimulation AKT1 AKT2 AKT3 CD28 CD80 CD86 CDC42 FYN GRAP2 GRB2 LCK LOC729120 LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 RAC1 RICTOR SRC THEM4 TRIB3 VAV1 YES1 +REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling AKT1 AKT2 AKT3 CD28 CD80 CD86 FYN LCK LOC729120 MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 RICTOR THEM4 TRIB3 +REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway CD28 CD80 CD86 CDC42 FYN GRB2 LCK PAK1 PAK2 RAC1 VAV1 +REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex CDC6 E2F1 E2F2 E2F3 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 LOC652826 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 +REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex CDC6 CDT1 GMNN LOC652826 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 +REACTOME_CELL_CELL_COMMUNICATION Genes involved in Cell-Cell communication ACTN1 ACTN2 ACTN4 ARHGEF6 CADM1 CADM2 CD151 CD2AP CD47 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL17A1 CRB3 CTNNA1 CTNNB1 CTNND1 DCC DSCAM DSCAML1 F11R FBLIM1 FERMT2 FLNC FYB FYN GRB2 ILK INADL IQGAP1 ITGB1 ITGB4 JUP KIRREL2 KIRREL3 LAMA3 LAMB3 LAMC2 LIMS1 LIMS3 LOC652460 LOC729030 MAGI2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MPP5 NCK1 NCK2 NPHS1 NTN1 PAK1 PARD3 PARD6A PARD6B PARD6G PARVA PARVB PIK3CA PIK3CB PIK3R1 PIK3R2 PLEC PRKCI PTK2 PTK2B PTPN6 PVR PVRL1 PVRL2 PVRL3 PVRL4 RAC1 RSU1 SIRPA SIRPB1 SIRPG SKAP2 SPTAN1 SPTBN1 SRC TESK1 TYROBP VASP WASL +REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization CADM1 CADM2 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 CTNNA1 CTNNB1 CTNND1 F11R INADL JUP MPP5 PARD3 PARD6A PARD6B PARD6G PRKCI PVR PVRL1 PVRL2 PVRL3 PVRL4 +REACTOME_CELL_CYCLE Genes involved in Cell Cycle ACD ACTR1A AHCTF1 AKAP9 ALMS1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APITD1 ATM ATR ATRIP AURKA AURKB AZI1 B9D2 BIRC5 BRCA1 BTRC BUB1 BUB1B BUB3 CASC5 CCDC99 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC14A CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC26P1 CDC27 CDC45 CDC6 CDC7 CDCA8 CDK1 CDK2 CDK4 CDK5RAP2 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CENPA CENPC1 CENPH CENPI CENPJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CEP135 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CETN2 CHEK1 CHEK2 CKAP5 CKS1B CLASP1 CLIP1 CNTRL CSNK1D CSNK1E CUL1 DBF4 DCTN1 DCTN2 DCTN3 DHFR DHFRP1 DIDO1 DKC1 DNA2 DSN1 DYNC1H1 DYNC1I2 DYNLL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 ERCC6L FBXO5 FEN1 FGFR1OP FKBP6 GINS1 GINS2 GINS4 GMNN GORASP1 H2AFX H2AFZ HAUS2 HDAC1 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HJURP HSP90AA1 HSPA2 HUS1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LIG1 LIN37 LIN52 LIN54 LIN9 LMNA LMNB1 LOC440577 LOC440917 LOC441488 LOC645084 LOC647654 LOC648152 LOC649620 LOC650621 LOC651610 LOC651763 LOC651921 LOC652826 LOC729964 LOC730418 LOC730594 MAD1L1 MAD2L1 MAPRE1 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MDM2 MIS12 MIS18A MIS18BP1 MLF1IP MNAT1 MYBL2 MYC NDC80 NDEL1 NEDD1 NEK2 NHP2 NINL NPM1 NSL1 NUDC NUF2 NUMA1 NUP107 NUP133 NUP37 NUP43 NUP85 OFD1 OIP5 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PCM1 PCNA PCNT PKMYT1 PLK1 PLK4 PMF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POT1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRIM1 PRIM2 PRKACA PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTTG1 RAD1 RAD17 RAD21 RAD9A RANBP2 RANGAP1 RB1 RBBP4 RBBP4P1 RBBP7 RBL1 RBL2 RCC2 REC8 RFC2 RFC3 RFC4 RFC5 RFWD2 RFWD2P1 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RPS27AP11 RRM2 RSF1 RUVBL1 RUVBL2 SDCCAG8 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SKA2L SKP1 SKP2 SMARCA5 SMC1A SMC1B SMC3 SPC24 SPC25 SSNA1 STAG1 STAG2 STAG3 SUN2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TAOK1 TERF1 TERF2 TERF2IP TERT TEX12 TFDP1 TINF2 TK2 TP53 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBBP2 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 TYMS UBA52 UBE2C UBE2D1 UBE2E1 UBE2I WEE1 WRAP53 XPO1 YWHAE YWHAG ZW10 ZWILCH ZWINT +REACTOME_CELL_CYCLE_CHECKPOINTS Genes involved in Cell Cycle Checkpoints ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ATM ATR ATRIP BUB1B BUB3 CCNB1 CCNB2 CCNE1 CCNE2 CDC16 CDC20 CDC23 CDC25A CDC25C CDC26 CDC26P1 CDC27 CDC45 CDC6 CDC7 CDK1 CDK2 CDKN1A CDKN1B CHEK1 CHEK2 DBF4 HUS1 LOC645084 LOC647654 LOC648152 LOC649620 LOC650621 LOC651610 LOC651763 LOC651921 LOC652826 LOC730594 MAD1L1 MAD2L1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MDM2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAD1 RAD17 RAD9A RFC2 RFC3 RFC4 RFC5 RFWD2 RFWD2P1 RPA1 RPA2 RPA3 RPS27A RPS27AP11 TP53 UBA52 UBE2C UBE2D1 UBE2E1 WEE1 +REACTOME_CELL_CYCLE_MITOTIC Genes involved in Cell Cycle, Mitotic ACTR1A AHCTF1 AKAP9 ALMS1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APITD1 AURKA AURKB AZI1 B9D2 BIRC5 BTRC BUB1 BUB1B BUB3 CASC5 CCDC99 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC14A CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC26P1 CDC27 CDC45 CDC6 CDC7 CDCA8 CDK1 CDK2 CDK4 CDK5RAP2 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CENPA CENPC1 CENPH CENPI CENPJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CEP135 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CETN2 CKAP5 CKS1B CLASP1 CLIP1 CNTRL CSNK1D CSNK1E CUL1 DBF4 DCTN1 DCTN2 DCTN3 DHFR DHFRP1 DNA2 DSN1 DYNC1H1 DYNC1I2 DYNLL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 ERCC6L FBXO5 FEN1 FGFR1OP GINS1 GINS2 GINS4 GMNN GORASP1 HAUS2 HDAC1 HSP90AA1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LIG1 LIN37 LIN52 LIN54 LIN9 LOC440917 LOC441488 LOC645084 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC729964 LOC730418 LOC730594 MAD1L1 MAD2L1 MAPRE1 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MIS12 MLF1IP MNAT1 MYBL2 MYC NDC80 NDEL1 NEDD1 NEK2 NINL NSL1 NUDC NUF2 NUMA1 NUP107 NUP133 NUP37 NUP43 NUP85 OFD1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PCM1 PCNA PCNT PKMYT1 PLK1 PLK4 PMF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRIM1 PRIM2 PRKACA PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTTG1 RAD21 RANBP2 RANGAP1 RB1 RBBP4 RBBP4P1 RBL1 RBL2 RCC2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RPS27AP11 RRM2 SDCCAG8 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SKA2L SKP1 SKP2 SMC1A SMC3 SPC24 SPC25 SSNA1 STAG1 STAG2 TAOK1 TFDP1 TK2 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBBP2 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 TYMS UBA52 UBE2C UBE2D1 UBE2E1 WEE1 XPO1 YWHAE YWHAG ZW10 ZWILCH ZWINT +REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE AATF ABR AKAP13 APH1A APH1B ARHGAP4 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 BAD BCL2L11 CASP2 CASP3 ECT2 FGD1 FGD2 FGD3 FGD4 ITGB3BP ITSN1 KALRN LOC440917 MAGED1 MAPK8 MCF2 NCSTN NET1 NGEF NGF NGFR NGFRAP1 OBSCN PLEKHG2 PREX1 PSEN1 PSEN2 PSENEN RAC1 RASGRF1 RASGRF2 RPS27A RPS27AP11 SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 VAV1 VAV3 YWHAE +REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions ACTN1 ARHGEF6 FBLIM1 FERMT2 FLNC ILK ITGB1 LIMS1 LIMS3 PARVA PARVB RSU1 TESK1 VASP +REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization ACTN1 ARHGEF6 CADM1 CADM2 CD151 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH18 CDH2 CDH24 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL17A1 CRB3 CTNNA1 CTNNB1 CTNND1 F11R FBLIM1 FERMT2 FLNC ILK INADL ITGB1 ITGB4 JUP LAMA3 LAMB3 LAMC2 LIMS1 LIMS3 LOC652460 MPP5 PARD3 PARD6A PARD6B PARD6G PARVA PARVB PLEC PRKCI PVR PVRL1 PVRL2 PVRL3 PVRL4 RSU1 TESK1 VASP +REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall AMICA1 ANGPT1 ANGPT2 ANGPT4 APOB ATP1B1 ATP1B2 ATP1B3 BSG CAV1 CD2 CD47 CD48 CD58 COL1A1 COL1A2 CXADR DOK2 ESAM F11R F2 FCER1G FN1 FYN GRB14 GRB2 GRB7 HRAS ITGA3 ITGA5 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 JAM2 JAM3 KRAS L1CAM LCK LOC128192 LOC131691 LOC643997 LOC652612 LOC654188 LYN MAG MERTK MMP1 NRAS OLR1 PECAM1 PF4 PF4V1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPIA PPIAP22 PPIAP8 PPIL2 PROC PROS1 PTPN6 SELL SELP SHC1 SIRPA SIRPG SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SOS1 SPN SRC TEK THBD TREM1 YES1 +REACTOME_CGMP_EFFECTS Genes involved in cGMP effects KCNMB1 KCNMB2 KCNMB3 KCNMB4 MRVI1 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE6A PDE6B PDE6G PDE9A PRKG1 PRKG2 +REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines CCBP2 CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL1P1 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 IL8 LOC728830 PF4 PPBP XCL1 XCL2 XCR1 +REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis CYP51A1 DHCR24 DHCR7 EBP FDFT1 FDPS GGPS1 HMGCR HMGCS1 HSD17B7 IDI1 IDI2 LBR LOC651621 LOC730412 LSS MSMO1 MVD MVK NSDHL PMVK SC5DL SQLE TM7SF2 +REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 DCN LOC644504 LOC644691 NCAN VCAN +REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST14 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 DCN DSE GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GXYLT1 GXYLT2 HEXA HEXB HSPG2 HYAL1 IDS IDUA LOC644504 LOC644691 NCAN SDC1 SDC2 SDC3 SDC4 UST VCAN +REACTOME_CHROMOSOME_MAINTENANCE Genes involved in Chromosome Maintenance ACD ATR BRCA1 CASC5 CENPA CENPH CENPI CENPK CENPN CENPO CENPP CENPQ DIDO1 DKC1 DNA2 FEN1 FKBP6 H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HJURP HSPA2 ITGB3BP LIG1 LMNA LMNB1 LOC440577 LOC648152 LOC651921 MIS18A MIS18BP1 MLF1IP NHP2 NPM1 OIP5 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POT1 PRIM1 PRIM2 RAD21 RBBP4 RBBP4P1 RBBP7 REC8 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RSF1 RUVBL1 RUVBL2 SMARCA5 SMC1A SMC1B SMC3 STAG1 STAG2 STAG3 SUN2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TERT TEX12 TINF2 UBE2I WRAP53 +REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport APOA1 APOA2 APOA5 APOB APOC2 APOC3 APOE HSPG2 LDLR LDLRAP1 LIPC LPL MTTP P4HB SAR1B SDC1 +REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock ARNTL ARNTL2 ATF2 AVP BHLHE40 BHLHE41 BTRC CCRN4L CLOCK CPT1A CREB1 CREBBP CRY1 CRY2 CSNK1D CSNK1E CUL1 DBP ELOVL3 EP300 F7 FBXL3 HDAC3 HIF1A MED1 MEF2C MEF2D NAMPT NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NPAS2 NR1D1 NR3C1 PER1 PER2 PPARA PPARGC1A PRIC285 RORA RPS27A RPS27AP11 RXRA SERPINE1 SKP1 SMARCD3 SREBF1 TBL1X TBL1XR1 TGS1 UBA52 +REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA ARNTL CLOCK CREBBP ELOVL3 EP300 HDAC3 MED1 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NPAS2 NR1D1 PPARA PPARGC1A PRIC285 RORA RXRA SMARCD3 TBL1X TBL1XR1 TGS1 +REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle) ACO2 CS DLD DLST FH IDH2 IDH3A IDH3B IDH3G LOC283398 LOC646675 LOC646677 LOC650667 LOC650674 LOC651820 MDH2 NNT OGDH SDHA SDHB SDHC SDHD SUCLA2 SUCLA2P1 SUCLG1 SUCLG2 +REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors) ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 ANXA1 APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CCBP2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL1P1 CGA CHRM1 CHRM2 CHRM3 CHRM5 CNR1 CNR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 CYSLTR1 CYSLTR2 DARC DRD1 DRD2 DRD3 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR1 FPR2 FPR3 FSHB FSHR GAL GALR1 GALR2 GALR3 GAST GHRL GHSR GNRH1 GNRH2 GNRHR GPBAR1 GPER GPR132 GPR17 GPR18 GPR39 GPR4 GPR44 GPR55 GPR65 GPR68 GPR77 GRP GRPR HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IL8 INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LOC652222 LOC653879 LOC728830 LOC730002 LOC730413 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MTNR1A MTNR1B NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY5R NTS NTSR1 NTSR2 O3FAR1 OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PPYR1 PRLH PRLHR PROK1 PROKR1 PROKR2 PTAFR PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PYY QRFP QRFPR RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TSHB TSHR UTS2 UTS2D UTS2R XCL1 XCL2 XCR1 +REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors) ADCYAP1 ADCYAP1R1 ADM ADM2 CALCA CALCB CALCRL CD55 CD97 CRH CRHR2 DHH EMR1 EMR2 EMR3 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IAPP IHH LOC649279 PTCH1 PTCH2 PTH PTH1R PTH2 PTH2R PTHLH RAMP1 RAMP2 RAMP3 SCT SCTR SHH SMO VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8B WNT9A WNT9B +REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) CASR GABBR1 GABBR2 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 LOC652292 TAS1R1 TAS1R2 TAS1R3 +REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ARIH2 ASB1 ASB11 ASB12 ASB13 ASB15 ASB16 ASB17 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATG7 B2M BLMH BTRC CALR CANX CBLB CD207 CD36 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDC34 CTSS CUL1 CUL2 CUL3 CUL5 CUL7 CYBA CYBB DET1 DTX3L DZIP3 ERAP1 FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCGR1A FCGR1B GAN HECTD3 HERC2 HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K HSPA5 HUWE1 ITGAV ITGB5 KEAP1 KLHL13 KLHL20 KLHL9 LNPEP LOC644006 LOC647654 LOC648998 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 LOC731049 LOC731429 LRR1 LRRC41 LRSAM1 MKRN1 MRC1 MRC2 NCF2 NCF4 NEDD4 NPEPPS PARK2 PDIA3 PJA1 PJA2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBCK1 RBX1 RCHY1 RNF123 RNF138 RNF144B RNF182 RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS27AP11 SAE1 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS3 SPSB1 SPSB2 SPSB4 STUB1 TAP1 TAP2 TCEB1 TCEB1P3 TCEB2 TMEM189-UBE2V1 TPP2 TRIM11 TRIM21 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 UBA1 UBA2 UBA3 UBA5 UBA52 UBA6 UBA7 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2HP1 UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 VHL VPRBP WSB1 WWP1 ZBTB16 +REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 LOC643446 LSM10 LSM11 MAGOH NCBP1 NCBP2 NFX1 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 THOC4 U2AF1 U2AF2 UPF3B ZNF473 +REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation ADAMTS14 ADAMTS2 ADAMTS3 BMP1 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL19A1 COL1A1 COL1A2 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 CRTAP GLT25D1 GLT25D2 LEPREL1 LEPREL2 P4HB PCOLCE PCOLCE2 PLOD1 PLOD2 PLOD3 PPIB SERPINH1 TLL1 TLL2 +REACTOME_COMMON_PATHWAY Genes involved in Common Pathway F10 F13A1 F13B F2 F5 FGA FGB FGG PF4 PF4V1 PROC PROS1 SERPINC1 THBD +REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade C1QA C1QB C1QC C1S C2 C3 C4A C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CD46 CD55 CFB CFD CFH CFHR3 CFI CR1 CRP LOC651536 LOC653879 LOC731066 MASP1 MASP2 MBL2 PROS1 +REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC14A CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 LOC647654 LOC649620 LOC650621 LOC651763 LOC730594 UBE2C UBE2D1 UBE2E1 +REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport ARCN1 ARF1 ARFGAP1 COPA COPB1 COPB2 COPE COPG COPZ1 GBF1 +REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY Genes involved in Costimulation by the CD28 family AKT1 AKT2 AKT3 BTLA CD247 CD274 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDC42 CSK CTLA4 FYN GRAP2 GRB2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 ICOS ICOSLG LCK LOC729120 LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PDCD1 PDCD1LG2 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN6 RAC1 RICTOR SRC THEM4 TNFRSF14 TRIB3 VAV1 YES1 +REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators C1QA C1QB C1QC C1S CRP LOC651536 LOC731066 MASP1 MASP2 MBL2 +REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII ACTN2 AKAP9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CREB1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL +REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras ACTN2 AKAP9 BRAF CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CREB1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling CDK5 CDK5R1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 FES FYN NRP1 PLXNA1 PLXNA2 PLXNA3 SEMA3A +REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) CD207 FCGR1A FCGR1B LOC652826 MRC1 MRC2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 +REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation ARSB BCAN BGN CSPG4 DCN HEXA HEXB HYAL1 IDS IDUA NCAN VCAN +REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling AKT1 AKT2 AKT3 CD80 CD86 CTLA4 FYN LCK LYN PDPK1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E SRC YES1 +REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade APC AXIN1 CSNK1A1 CTNNB1 FAM123B FRAT1 FRAT2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E +REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition CCNA1 CCNA2 CCNB1 CCNB2 CCNH CDC25A CDC25B CDC25C CDK1 CDK7 MNAT1 PKMYT1 PLK1 WEE1 XPO1 +REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition CCNA1 CCNA2 CCNE1 CCNE2 CCNH CDC25A CDK2 CDK7 CDKN1A CDKN1B CKS1B CUL1 LOC652826 LOC729964 MAX MNAT1 MYC PKMYT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RB1 RPS27A RPS27AP11 SKP1 SKP2 UBA52 WEE1 +REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 LOC731992 POMC PTGIS TBXAS1 +REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM Genes involved in Cytokine Signaling in Immune system AAAS ADAM17 ADAR ARIH1 B2M BLNK BTRC CAMK2A CAMK2B CAMK2D CASP1 CBL CD44 CDK1 CHUK CIITA CISH CRK CRKL CSF2 CSF2RA CSF2RB CSH1 CUL1 DDX58 EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FCGR1A FCGR1B FLNB FYN GAB2 GBP1 GBP2 GBP4 GBP5 GBP6 GBP7 GH1 GH2 GHR GRB2 HCK HERC5 HGF HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 HLA-F HLA-G HLA-K HRAS ICAM1 IFI27 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IKBKB IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPPL1 IP6K2 IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 IRS1 IRS2 ISG15 ISG20 JAK1 JAK2 JAK3 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNB1 KRAS LCK LOC144383 LOC441019 LOC646981 LOC649891 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK3 MT2A MX1 MX2 MYD88 NCAM1 NEDD4 NFKB2 NOD1 NOD2 NRAS NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL PELI1 PELI2 PELI3 PIAS1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIN1 PLCG1 PML POM121 PPM1B PRKACB PRKCD PRL PRLR PSMB8 PTAFR PTK2B PTPN1 PTPN2 PTPN6 RAE1 RAF1 RANBP2 RAPGEF1 RBX1 RELA RIPK2 RNASEL RPS27A RPS27AP11 SEH1L SH2B1 SHC1 SKP1 SOCS1 SOCS2 SOCS3 SOS1 SP100 SQSTM1 STAT1 STAT2 STAT3 STAT5A STAT5B SUMO1 SYK TAB1 TAB2 TAB3 TEC TMEM189-UBE2V1 TNIP2 TOLLIP TPR TRAF6 TRIM25 TYK2 UBA52 UBA7 UBE2E1 UBE2L6 UBE2N USP18 VAV1 VCAM1 XAF1 YES1 YWHAB YWHAZ +REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules BPNT1 PAPSS1 PAPSS2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 +REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation AARS AIMP1 AIMP2 CARS DARS EEF1E1 EPRS FARSA FARSB GARS HARS IARS KARS LARS MARS NARS PPA1 QARS RARS SARS TARS VARS WARS YARS +REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CALM2 CALM3 CAMK4 CREB1 ITPR2 ITPR3 LOC730418 PDE1A PDE1B PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events CALM1 CALM2 CALM3 CDK5 LOC730418 PDE4B PDE4C PDE4D PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling ABLIM1 ABLIM3 CDC42 DCC DOCK1 FYN NCK1 NTN1 PTK2 RAC1 SRC TRIO WASL +REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY Genes involved in Deadenylation-dependent mRNA decay C2orf29 CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT7 CNOT8 DCP1A DCP1B DCP2 DCPS DDX6 DIS3 EDC3 EDC4 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 LOC645139 LOC645947 LOC651789 LOC652607 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 PABPC1 PAIP1 PARN PATL1 RQCD1 TNKS1BP1 XRN1 +REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA C2orf29 CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT7 CNOT8 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 LOC645139 LOC651789 LOC652607 PABPC1 PAIP1 PARN RQCD1 TNKS1BP1 +REACTOME_DEFENSINS Genes involved in Defensins ART1 CCR2 CCR6 CD4 DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B LOC729523 LOC731949 PRSS2 TLR1 TLR2 +REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix CMA1 CTRB1 CTRB2 CTSG ELANE FURIN KLK2 KLKB1 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 PLG PRSS1 PRSS2 TIMP1 TIMP2 TPSAB1 +REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere CASC5 CENPA CENPH CENPI CENPK CENPN CENPO CENPP CENPQ H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HJURP ITGB3BP LOC440577 MIS18A MIS18BP1 MLF1IP NPM1 OIP5 RBBP4 RBBP4P1 RBBP7 RSF1 RUVBL1 SMARCA5 +REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) EIF4G1 HNRNPD HSPA1B HSPA8 HSPB1 LOC652607 LOC652826 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 +REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) AKT1 DCP1A DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MAPKAPK2 XRN1 YWHAB ZFP36L1 +REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP AKT1 DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KHSRP MAPK11 MAPK14 PARN YWHAZ +REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) DCP1A DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MAPKAPK2 TNPO1 XRN1 YWHAB ZFP36 +REACTOME_DEVELOPMENTAL_BIOLOGY Genes involved in Developmental Biology ABL1 ABL2 ABLIM1 ABLIM3 ACVR1B ACVR1C ACVR2A ACVR2B ADIPOQ AGRN AKT1 AKT2 AKT3 ALCAM ANGPTL4 ANK1 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGAP35 ARHGEF11 ARHGEF12 ARTN BNIP2 BOC CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CAP1 CAP2 CCNC CCND3 CD24 CD36 CD72 CDC42 CDH15 CDH2 CDH4 CDK1 CDK19 CDK4 CDK5 CDK5R1 CDK8 CDON CEBPB CEBPD CER1 CFL1 CLASP1 CLTA CLTC CNTN1 CNTN2 CNTN6 CNTNAP1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 CREB1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CSNK2B CTNNA1 CTNNB1 DCC DCX DLG1 DLG3 DNM1 DNM2 DOCK1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 DRAP1 EBF1 EGFR EGR2 ENAH EP300 ERBB2 EVL EZR FABP4 FARP2 FES FGF10 FGFR1 FOXA2 FOXA3 FOXH1 FOXO1 FOXO3 FURIN FYN GCK GDF1 GDNF GFRA1 GFRA2 GFRA4 GPC1 GRB2 HDAC3 HES1 HFE2 HNF1A HNF1B HNF4A HNF4G HRAS HSP90AA1 HSP90AB1 IAPP INS INSM1 ITGA1 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 KCNQ2 KCNQ3 KIAA1598 KIF4A KIF4B KLF4 KLF5 KRAS L1CAM LAMA1 LAMB1 LAMC1 LEFTY1 LEFTY2 LEP LIMK1 LIMK2 LOC642076 LOC644816 LOC650400 LOC729030 LOC730030 LOC730221 LOC730335 LOC731231 LPL MAFA MAP2K1 MAP2K2 MAP2K6 MAPK1 MAPK11 MAPK12 MAPK14 MAPK3 MED1 MED10 MED11 MED12 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MEF2A MEF2BNB MEF2BNB-MEF2B MEF2C MEF2D MET MSN MYF5 MYF6 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL8P MYL9 MYO10 MYOD1 MYOG NCAM1 NCAN NCK1 NCK2 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NEO1 NEUROD1 NEUROG3 NKX2-2 NKX6-1 NODAL NR2F2 NR5A2 NRAS NRCAM NRP1 NRP2 NRTN NTN1 NTN3 NTN4 NUMB ONECUT1 ONECUT3 PAK1 PAK2 PAK4 PAK6 PAK7 PAX6 PCK1 PCSK6 PDX1 PFN1 PFN2 PIP5K1C PITPNA PKLR PLCG1 PLIN1 PLXNA1 PLXNA2 PLXNA3 PLXNB1 PLXNB3 PLXNC1 PLXND1 PPARA PPARG PPARGC1A PRIC285 PRKCQ PRNP PSPN PTF1A PTK2 PTPRC RAC1 RAC2 RAF1 RANBP9 RBPJ RDX RELA RGMA RGMB RHOA RHOB RHOC RHOG RND1 ROBO1 ROBO2 ROBO3 ROCK1 ROCK1P1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS RXRA SCN1B SCN2A SCN2B SCN3B SCN4A SCN5A SCN7A SCN8A SDCBP SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A SH3GL2 SIAH1 SIAH2 SLC2A2 SLC2A4 SLIT1 SLIT2 SLIT3 SMAD2 SMAD3 SMAD4 SMARCD3 SOS1 SOS2 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC SREBF1 SRGAP1 SRGAP2 SRGAP3 ST8SIA2 ST8SIA4 STIP1 TBL1X TBL1XR1 TCF12 TCF3 TCF4 TDGF1 TGFB1 TGS1 TLN1 TNF TREM2 TRIO TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TYROBP UNC5A UNC5B UNC5C UNC5D VASP WASL WNT1 WNT10B YWHAB +REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways ACADVL ADD1 ARFGAP1 ASNS ATF3 ATF4 ATF4P3 ATF6 ATP6V0D1 BCHE C19orf10 CALR CCL2 CPE CTDSP2 CTSG CUL7 CXXC1 DCP2 DCTN1 DDIT3 DDX11 DDX12P DIS3 DNAJB11 DNAJB9 DNAJC3 EDEM1 EIF2AK3 EIF2S1 ERN1 ERO1L EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC8 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXTL3 F2 FKBP14 GCG GH1 GHRL GOSR2 GSK3A HDGF HERPUD1 HSP90B1 HSPA5 HYOU1 IGF2 IGF2BP1 IGF2BP2 IGF2BP3 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IL8 INS KDELR3 KHSRP KIF5B KLF4 KLHDC3 KLK3 LEP LMNA LOC644556 LOC653566 LOC730136 MBOAT4 MBTPS1 MBTPS2 MMP1 MMP2 MYO5A NFYA NFYB PAPPA PAPPA2 PARN PCSK1 PCSK2 PDIA5 PDIA6 PLA2G7 PLG PPP2R5B PREB RAB27A SEC11A SEC11C SEC31A SERP1 SHC1 SLC30A5 SLC30A7 SNAP25 SPCS1 SPCS2 SPCS3 SRPR SRPRB SSR1 STX1A SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 VAMP2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate AMY1A AMY1B AMY1C AMY2A AMY2B LCT LOC648749 LOC652899 LOC730924 MGAM SI TREH +REACTOME_DNA_REPAIR Genes involved in DNA Repair ALKBH2 ALKBH3 APEX1 ATM ATR BRCA1 BRCA2 BRIP1 C17orf70 C19orf40 CCNH CCNO CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCL FANCM FEN1 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 H2AFX LIG1 LIG3 LIG4 LOC389901 LOC648152 LOC651610 LOC651921 LOC652672 LOC652857 MAD2L2 MBD4 MDC1 MGMT MNAT1 MPG MRE11A MUTYH NBN NTHL1 OGG1 PALB2 PCNA POLB POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRKDC RAD23B RAD50 RAD51 RAD52 REV1 REV3L RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A RPS27AP11 SMUG1 TCEA1 TDG TDP1 TP53BP1 UBA52 UBE2T USP1 XAB2 XPA XPC XRCC1 XRCC4 XRCC5 XRCC6 ZBTB32 +REACTOME_DNA_REPLICATION Genes involved in DNA Replication AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CCDC99 CCNA1 CCNA2 CDC20 CDC45 CDC6 CDC7 CDCA8 CDK2 CDKN1A CDKN1B CDT1 CENPA CENPC1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CKAP5 CLASP1 CLIP1 DBF4 DNA2 DSN1 E2F1 E2F2 E2F3 ERCC6L FBXO5 FEN1 GINS1 GINS2 GINS4 GMNN GORASP1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LIG1 LOC645084 LOC652826 MAD1L1 MAD2L1 MAPRE1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MIS12 MLF1IP NDC80 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP37 NUP43 NUP85 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PCNA PLK1 PMF1 POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAD21 RANBP2 RANGAP1 RB1 RCC2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RPS27AP11 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SKA2L SMC1A SMC3 SPC24 SPC25 STAG1 STAG2 TAOK1 UBA52 XPO1 ZW10 ZWILCH ZWINT +REACTOME_DNA_STRAND_ELONGATION Genes involved in DNA strand elongation CDC45 DNA2 FEN1 GINS1 GINS2 GINS4 LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle RAB3A RIMS1 SLC18A2 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 VAMP2 +REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair ATM BRCA1 BRCA2 BRIP1 H2AFX LIG1 LIG4 LOC389901 LOC651610 MDC1 MRE11A NBN PRKDC RAD50 RAD51 RAD52 RPA1 RPA2 RPA3 TDP1 TP53BP1 XRCC4 XRCC5 XRCC6 +REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling AKT1 AKT2 AKT3 ERBB2 ERBB3 NRG1 NRG2 RNF41 RPS27A RPS27AP11 UBA52 USP8 +REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity HDAC1 NCOR1 NCOR2 PARP1 PPM1A RPS27A RPS27AP11 SKI SKIL SMAD2 SMAD3 SMAD4 SMURF2 TGIF1 TGIF2 TRIM33 UBA52 UBE2D1 UBE2D3 USP9X +REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling LOC731429 MTMR4 PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A RPS27AP11 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA52 UCHL5 XPO1 ZFYVE9 +REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD BCAR1 CALM1 CALM2 CALM3 CAMK4 CASP9 CDK1 CDKN1A CDKN1B CHUK CREB1 CRK CRKL FOXO1 FOXO3 FOXO4 GRB2 GRB7 GSK3A HRAS ITPR2 ITPR3 KRAS LOC729030 LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MTOR NCK1 NCK2 NR4A1 NRAS PDE1A PDE1B PDGFA PDGFB PDGFRA PDGFRB PDPK1 PHLPP1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RAPGEF1 RASA1 RICTOR RPS6KB2 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THEM4 TRIB3 TSC2 YWHAB +REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) AKT1 AKT1S1 AKT2 AKT3 BAD BCL10 BTRC CARD11 CASP9 CDKN1A CDKN1B CHUK CREB1 CUL1 FBXW11 FOXO1 FOXO3 FOXO4 GSK3A HRAS IKBKB IKBKG KRAS LOC646626 LOC652826 LOC729120 LOC731292 MALT1 MAP3K7 MAPKAP1 MDM2 MLST8 MTOR NFKBIA NFKBIB NFKBIE NR4A1 NRAS PDPK1 PHLPP1 PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTEN RASGRP1 RASGRP3 REL RELA RICTOR RPS27A RPS27AP11 RPS6KB2 SKP1 THEM4 TRIB3 TSC2 UBA52 +REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR Genes involved in Downstream signaling of activated FGFR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD CALM1 CALM2 CALM3 CAMK4 CASP9 CDK1 CDKN1A CDKN1B CHUK CREB1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 GAB1 GRB2 GSK3A HRAS ITPR2 ITPR3 KL KLB KRAS LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MTOR NR4A1 NRAS PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3R1 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RICTOR RPS6KB2 SHC1 SOS1 THEM4 TRIB3 TSC2 YWHAB +REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling BCL10 CARD11 CD247 CD3D CD3E CD3G CD4 CHUK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 IKBKB IKBKG LCK LOC646626 LOC731292 MALT1 MAP3K7 NFKBIA PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKCQ PTEN RELA RIPK2 TAB2 TMEM189-UBE2V1 TRAF6 TRAT1 UBE2N +REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions DCC DSCAM DSCAML1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 NTN1 PAK1 RAC1 +REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation CCNB1 CDC25A CDK1 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 +REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION Genes involved in E2F mediated regulation of DNA replication CCNA1 CCNB1 CCNE1 CDC25A CDC45 CDC6 CDK1 CDT1 DHFR DHFRP1 E2F1 FBXO5 LOC441488 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 RRM2 TFDP1 TK2 TYMS +REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle BANF1 CCR5 CD4 CXCR4 FEN1 HMGA1 LIG1 LIG4 LOC128192 LOC131691 LOC389901 LOC643997 LOC645870 LOC654188 PPIA PPIAP22 PPIAP8 PSIP1 XRCC4 XRCC5 XRCC6 +REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ ITPR2 ITPR3 LOC730221 LOC730335 MGLL PRKCD PRKCE PRKCH PRKCQ RASGRP1 RASGRP2 TRPC3 TRPC6 TRPC7 +REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CBL CDC42 CLTA CLTC EGF EGFR EPN1 EPS15 EPS15L1 GRB2 HGS RPS27A RPS27AP11 SH3GL2 SH3KBP1 SPRY1 SPRY2 STAM STAM2 UBA52 +REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors CYSLTR1 CYSLTR2 GPR17 GPR44 LOC730002 LTB4R LTB4R2 OXER1 PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R +REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels ITPR2 ITPR3 LOC730221 LOC730335 ORAI1 P2RX1 STIM1 TRPC3 TRPC6 TRPC7 +REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery CCNT1 CCNT2 CDK9 COBRA1 CTDP1 ELL GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RDBP SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L WHSC2 +REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1B1 CYP21A2 CYP27A1 CYP39A1 CYP46A1 CYP51A1 CYP7A1 CYP7B1 CYP8B1 POMC +REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 HGS RPS27A RPS27AP11 SNF8 STAM STAM2 TSG101 UBA52 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 +REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway B2M CTSS HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K LNPEP +REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK CAB39 CAB39L LOC644462 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPTOR STK11 STRADA STRADB TSC1 TSC2 +REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation AKT1 CALM1 CALM2 CALM3 CAV1 DHFR DHFRP1 DNM2 GCH1 GCHFR HSP90AA1 LYPLA1 NOS3 NOSIP NOSTRIN PRKG2 PTS SPR WASL ZDHHC21 +REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway B2M CALR HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K LOC652826 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 SEC61A1 SEC61A2 SEC61B SEC61G TAP1 TAP2 UBA52 +REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets DUSP3 DUSP4 DUSP6 DUSP7 ELK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated DUSP3 DUSP4 DUSP6 DUSP7 MAPK1 MAPK3 MAPK7 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D +REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 +REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres DKC1 DNA2 FEN1 LIG1 NHP2 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RUVBL1 RUVBL2 TERT WRAP53 +REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization ADAMTS14 ADAMTS2 ADAMTS3 BMP1 CMA1 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL19A1 COL1A1 COL1A2 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 CRTAP CTRB1 CTRB2 CTSG ELANE FURIN GLT25D1 GLT25D2 KLK2 KLKB1 LEPREL1 LEPREL2 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 P4HB PCOLCE PCOLCE2 PLG PLOD1 PLOD2 PLOD3 PPIB PRSS1 PRSS2 SERPINH1 TIMP1 TIMP2 TLL1 TLL2 TPSAB1 +REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis CASP10 CASP8 CFLAR FADD FAS FASLG RIPK1 TNF TNFRSF10B TNFRSF1A TNFSF10 TRADD TRAF2 +REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 +REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production ABL1 AK3 AKAP1 AKAP10 CABLES1 CABLES2 CAPZA1 CAPZA2 CBX5 CDC42 CDK2 CDK5 CREBBP DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK8 DOCK9 EHD1 EHD2 EP300 GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 H3F3A H3F3AP5 H3F3AP6 H3F3B HBB HBD HBE1 HBG2 HDAC1 HDAC2 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HMG20B IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IRF1 IRF2 IRF3 IRF7 ITPK1 JAK2 JMJD1C KDM1A KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 LOC441511 LOC730418 LOC731820 MAFF MAFG MAFK MFN1 MFN2 MYB NFE2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB5A RAC1 RACGAP1 RAD51B RAD51C RCOR1 SH2B1 SH2B2 SH2B3 SIN3A TP53 VPS45 WEE1 ZFPM1 ZFPM2 ZFYVE20 +REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway ATM ATR BRCA1 BRCA2 C17orf70 C19orf40 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCL FANCM LOC648152 LOC651610 LOC651921 PALB2 RPS27A RPS27AP11 UBA52 UBE2T USP1 ZBTB32 +REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism ABCA1 ABCB4 ACACA ACACB ACADL ACADM ACADS ACADVL ACAT1 ACLY ACOX1 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 AGT ALAS1 ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARNTL BDH1 CCNC CD36 CDK19 CDK8 CLOCK CPT1A CPT1B CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 DECR1 DGAT1 DGAT2 ECHS1 ECI1 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 EP300 ESRRA FABP1 FADS1 FASN FDFT1 FHL2 G0S2 GK GLIPR1 GPAM GPAT2 GPD1 GPD1L GPD2 GRHL1 HADH HADHA HADHB HDAC3 HMGCL HMGCR HMGCS1 HMGCS2 HSD17B12 LCLAT1 LPCAT1 LPCAT4 LPIN1 LPIN2 LPIN3 MCEE ME1 MED1 MED10 MED11 MED12 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MUT NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NFYA NFYB NPAS2 NR1D1 NRF1 OXCT1 PCCA PCCB PEX11A PLIN2 PPARA PPARG PPARGC1A PPARGC1B PRIC285 PRKAA2 PRKAB2 PRKAG2 RORA RXRA SIN3A SIN3B SLC25A1 SLC25A20 SLC27A1 SMARCD3 SREBF1 SREBF2 SULT2A1 TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TECR TGS1 TIAM2 TNFRSF21 TRIB3 TXNRD1 UGT1A9 WWTR1 YAP1 +REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis ACACA ACLY ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 FASN HSD17B12 SLC25A1 TECR +REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 +REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation FGF1 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR2 +REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation FGF1 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 +REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR ligand binding and activation FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 KL KLB +REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6 ATP8 LOC642727 +REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade) A2M C1QBP F10 F11 F12 F13A1 F13B F2 F3 F5 F7 F8 F9 FGA FGB FGG GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PF4 PF4V1 PRCP PROC PROS1 SERPINC1 SERPING1 TFPI THBD VWF +REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652672 LOC652857 MNAT1 RAD23B RPA1 RPA2 RPA3 XPA XPC +REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex CCNH CCNT1 CCNT2 CDK7 CDK9 COBRA1 CTDP1 ELL ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RDBP SSRP1 SUPT16H SUPT4H1 SUPT5H TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L WHSC2 +REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex CCNH CDK7 COBRA1 CTDP1 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RDBP SUPT4H1 SUPT5H TH1L WHSC2 +REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3FP3 EIF3G EIF3H EIF3I EIF3J EIF3K FAU LOC651894 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 +REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex CCNH CDK7 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TCEA1 XAB2 +REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 LOC654264 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 +REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade CDK1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 FRS3 GRB2 HRAS KL KLB KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 SOS1 YWHAB +REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1 CCNA1 CCNA2 CCNE1 CCNE2 CDC25A CDC6 CDK1 CDK2 DYRK1A E2F1 E2F4 E2F5 HDAC1 LIN37 LIN52 LIN54 LIN9 LOC441488 MYBL2 PCNA RBBP4 RBBP4P1 RBL1 RBL2 TFDP1 +REACTOME_G1_PHASE Genes involved in G1 Phase CCND1 CCND2 CCND3 CCNH CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CKS1B CUL1 E2F1 E2F2 E2F3 E2F4 E2F5 LOC441488 LOC729964 MNAT1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B RB1 RBL1 RBL2 RPS27A RPS27AP11 SKP1 SKP2 TFDP1 UBA52 +REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription CCNA1 CCNE1 CDC25A CDC45 CDC6 CDK1 CDT1 DHFR DHFRP1 E2F1 FBXO5 LOC441488 ORC1 PCNA POLA1 RRM2 TFDP1 TK2 TYMS +REACTOME_G1_S_TRANSITION Genes involved in G1/S Transition CCNA1 CCNA2 CCNB1 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DBF4 DHFR DHFRP1 E2F1 FBXO5 LOC441488 LOC645084 LOC652826 LOC729964 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 POLA1 POLA2 POLE POLE2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RB1 RPA1 RPA2 RPA3 RPA4 RPS27A RPS27AP11 RRM2 SKP1 SKP2 TFDP1 TK2 TYMS UBA52 WEE1 +REACTOME_G2_M_CHECKPOINTS Genes involved in G2/M Checkpoints ATM ATR ATRIP CCNB1 CCNB2 CDC25A CDC25C CDC45 CDC6 CDC7 CDK1 CDK2 CHEK1 CHEK2 DBF4 HUS1 LOC645084 LOC648152 LOC651610 LOC651921 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RAD1 RAD17 RAD9A RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 WEE1 +REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint ATM ATR ATRIP CCNB1 CDC25C CDK1 CHEK1 CHEK2 LOC648152 LOC651610 LOC651921 WEE1 +REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events ABR ADRA1A ADRA1B ADRA1D AKAP13 ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 CDC42 ECT2 FGD1 FGD2 FGD3 FGD4 GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITSN1 KALRN MCF2 NET1 NGEF OBSCN PIK3CA PIK3R1 PIK3R2 PIK3R3 PLEKHG2 PLXNB1 PREX1 RAC1 RAC2 RASGRF1 RASGRF2 RHOA RHOB RHOC RHOG ROCK1 ROCK1P1 ROCK2 SOS1 SOS2 TBXA2R TIAM1 TIAM2 TRIO VAV1 VAV3 +REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA1 ADORA3 ADRA2A ADRA2B AGT AGTR2 ANXA1 APLNR APP BDKRB1 BDKRB2 C3 C3AR1 C5 C5AR1 CASR CCL16 CCL19 CCL20 CCL21 CCL25 CCL27 CCL28 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CHRM2 CNR1 CNR2 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 DRD2 DRD3 FPR1 FPR2 FPR3 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GNAI1 GNAI2 GNAI3 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPER GPR17 GPR18 GPR44 GPR55 HCAR2 HCAR3 HEBP1 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR5A IL8 INSL5 KNG1 LOC652222 LOC653879 LPAR1 LPAR2 LPAR3 MCHR1 MCHR2 MTNR1A MTNR1B NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPW NPY NPY1R NPY2R NPY5R OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 P2RY12 P2RY13 P2RY14 P2RY4 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PPYR1 PTGER3 PYY RGR RGS1 RGS11 RGS12 RGS18 RGS19 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RLN3 RRH RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 +REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events ADRA1A ADRA1B ADRA1D ADRBK1 AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 CASR CCK CCKAR CCKBR CHRM1 CHRM3 CHRM5 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPR132 GPR17 GPR4 GPR65 GPR68 GPRC6A GRK5 GRP GRPR HCRT HCRTR1 HCRTR2 HRH1 HTR2A HTR2B HTR2C ITPR2 ITPR3 KALRN KISS1 KISS1R KNG1 LOC730221 LOC730335 LOC730413 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MCHR1 MCHR2 MGLL MLN MLNR NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PRKCD PRKCE PRKCH PRKCQ PROK1 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RASGRP1 RASGRP2 RGS18 RGS19 RGS2 RGS21 SAA1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO TRPC3 TRPC6 TRPC7 UTS2 UTS2D UTS2R XCL1 XCL2 XCR1 +REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA2A ADORA2B ADRB1 ADRB2 ADRB3 AVP AVPR2 CALCA CALCB CALCRL CGA CRH CRHR2 DRD1 DRD5 FSHB FSHR GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAI1 GNAI2 GNAI3 GNAS GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPBAR1 HRH2 HTR4 HTR6 HTR7 IAPP INSL3 LHB LHCGR LOC730002 MC1R MC2R MC3R MC4R MC5R NPS NPSR1 P2RY11 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B POMC PTGDR PTGER2 PTGER4 PTGIR PTH PTH1R PTH2 PTH2R PTHLH RAMP1 RAMP2 RAMP3 RLN2 RLN3 RXFP1 RXFP2 SCT SCTR TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TSHB TSHR VIP VIPR1 VIPR2 +REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A ADRA2B GNAI1 GNAI2 GNAI3 GNAS GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ RGS17 RGS19 RGS20 RGS4 +REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma AKT1 AKT2 AKT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PDPK1 PIK3CG PIK3R5 PIK3R6 RHOA +REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PLCB1 PLCB2 PLCB3 +REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation GNAI1 GNAI2 GNAI3 GNAO1 GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 OPRM1 PDYN POMC +REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING Genes involved in G-protein beta:gamma signalling AKT1 AKT2 AKT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PDPK1 PIK3CG PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 RHOA +REACTOME_GAB1_SIGNALOSOME Genes involved in GAB1 signalosome AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 CSK EGF EGFR FOXO1 FOXO3 FOXO4 GAB1 GRB2 GSK3A LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NR4A1 PAG1 PDPK1 PHLPP1 PIK3CA PIK3R1 PTEN RICTOR RPS6KB2 SRC THEM4 TRIB3 TSC2 +REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation ARHGEF9 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 +REACTOME_GABA_B_RECEPTOR_ACTIVATION Genes involved in GABA B receptor activation ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GABBR1 GABBR2 GNAI1 GNAI2 GNAI3 GNAL GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +REACTOME_GABA_RECEPTOR_ACTIVATION Genes involved in GABA receptor activation ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ARHGEF9 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GNAI1 GNAI2 GNAI3 GNAL GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation ABAT ALDH5A1 DNAJC5 GAD1 GAD2 HSPA8 RAB3A RIMS1 SLC32A1 SLC6A1 SLC6A11 SLC6A12 SNAP25 STX1A STXBP1 SYT1 VAMP2 +REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F10 F2 F7 F9 FURIN GGCX LOC652612 PROC PROS1 PROZ VKORC1 +REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD4 +REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 MYO6 +REACTOME_GAP_JUNCTION_TRAFFICKING Genes involved in Gap junction trafficking AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD4 MYO6 +REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK ADRA1A ADRA1B ADRA1D ADRBK1 AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 CASR CCK CCKAR CCKBR CDK1 CHRM1 CHRM3 CHRM5 CREB1 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ EDN1 EDN2 EDN3 EDNRA EDNRB EGFR F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPR132 GPR17 GPR4 GPR65 GPR68 GPRC6A GRB2 GRK5 GRP GRPR HBEGF HCRT HCRTR1 HCRTR2 HRAS HRH1 HTR2A HTR2B HTR2C ITPR2 ITPR3 KALRN KISS1 KISS1R KNG1 KRAS LOC730221 LOC730335 LOC730413 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK7 MCHR1 MCHR2 MGLL MLN MLNR MMP3 NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NRAS NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PRKCA PRKCD PRKCE PRKCH PRKCQ PROK1 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RAF1 RASGRP1 RASGRP2 RGS18 RGS19 RGS2 RGS21 RPS6KA1 RPS6KA2 RPS6KA3 SAA1 SOS1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO TRPC3 TRPC6 TRPC7 UTS2 UTS2D UTS2R XCL1 XCL2 XCR1 YWHAB +REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules CD247 CD3D CD3E CD3G CD4 ENAH EVL FYB GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 ITK LAT LCK LCP2 NCK1 PAK1 PAK2 PLCG1 VASP WAS ZAP70 +REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway AR CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CREBBP CTGF E2F4 E2F5 ESR1 ESR2 ESRRA ESRRB ESRRG HDAC1 HNF4A HNF4G JUNB KAT2A KAT2B LOC100287908 LOC100288042 LOC441488 LOC728030 LOC728381 LOC731106 LOC731863 MAML1 MAML2 MAML3 MAMLD1 MED1 MED10 MED12 MED14 MED15 MED16 MED17 MED20 MED23 MED24 MED25 MED26 MED27 MED30 MED31 MED4 MED6 MED7 MED8 MEN1 MYC NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NOTCH2 NOTCH3 NOTCH4 NPPA NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1I2 NR1I3 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 PARP1 PGR PPARA PPARD PPARG PPM1A PRIC285 RARA RARG RBL1 RBPJ RORA RORB RORC RPS27A RPS27AP11 RUNX2 RXRA RXRB RXRG SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMARCD3 SMURF2 SNW1 SP1 TBL1X TBL1XR1 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 TFDP1 TGIF1 TGIF2 TGS1 THRA THRB TRIM28 TRIM33 UBA52 UBE2D1 UBE2D3 USP9X VDR WWTR1 YAP1 ZFP1 ZFP112 ZFP2 ZFP28 ZFP37 ZFP90 ZIK1 ZIM2 ZIM3 ZKSCAN1 ZKSCAN3 ZKSCAN4 ZKSCAN5 ZNF10 ZNF100 ZNF101 ZNF114 ZNF12 ZNF136 ZNF138 ZNF14 ZNF140 ZNF141 ZNF154 ZNF155 ZNF157 ZNF160 ZNF167 ZNF169 ZNF17 ZNF175 ZNF18 ZNF180 ZNF184 ZNF189 ZNF19 ZNF192 ZNF197 ZNF2 ZNF20 ZNF200 ZNF202 ZNF205 ZNF208 ZNF211 ZNF212 ZNF213 ZNF214 ZNF215 ZNF221 ZNF222 ZNF223 ZNF224 ZNF225 ZNF226 ZNF227 ZNF23 ZNF230 ZNF234 ZNF235 ZNF248 ZNF25 ZNF250 ZNF254 ZNF256 ZNF26 ZNF263 ZNF264 ZNF266 ZNF267 ZNF273 ZNF274 ZNF28 ZNF282 ZNF285 ZNF286A ZNF287 ZNF3 ZNF30 ZNF300 ZNF304 ZNF311 ZNF317 ZNF320 ZNF324 ZNF331 ZNF333 ZNF334 ZNF337 ZNF33A ZNF33B ZNF343 ZNF347 ZNF350 ZNF354A ZNF354B ZNF354C ZNF37A ZNF382 ZNF383 ZNF394 ZNF398 ZNF415 ZNF416 ZNF417 ZNF418 ZNF419 ZNF420 ZNF425 ZNF426 ZNF43 ZNF430 ZNF431 ZNF432 ZNF433 ZNF434 ZNF436 ZNF439 ZNF440 ZNF441 ZNF442 ZNF443 ZNF445 ZNF446 ZNF45 ZNF454 ZNF460 ZNF468 ZNF471 ZNF473 ZNF479 ZNF480 ZNF483 ZNF484 ZNF485 ZNF490 ZNF492 ZNF493 ZNF496 ZNF498 ZNF500 ZNF506 ZNF510 ZNF514 ZNF517 ZNF519 ZNF528 ZNF529 ZNF530 ZNF540 ZNF543 ZNF544 ZNF546 ZNF547 ZNF548 ZNF551 ZNF552 ZNF555 ZNF556 ZNF557 ZNF558 ZNF559 ZNF560 ZNF561 ZNF563 ZNF564 ZNF565 ZNF566 ZNF567 ZNF569 ZNF570 ZNF571 ZNF577 ZNF582 ZNF583 ZNF584 ZNF585A ZNF585B ZNF587 ZNF589 ZNF595 ZNF596 ZNF597 ZNF599 ZNF600 ZNF605 ZNF606 ZNF607 ZNF610 ZNF611 ZNF613 ZNF614 ZNF615 ZNF616 ZNF619 ZNF620 ZNF621 ZNF624 ZNF625 ZNF627 ZNF641 ZNF642 ZNF643 ZNF649 ZNF655 ZNF658 ZNF658B ZNF708 ZNF773 ZNF806 ZNF92 ZNF98 +REACTOME_GLOBAL_GENOMIC_NER_GG_NER Genes involved in Global Genomic NER (GG-NER) CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LIG1 LOC652672 LOC652857 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RAD23B RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 XPA XPC +REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION Genes involved in Glucagon signaling in metabolic regulation ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GCG GCGR GNAS GNB1 GNB2 GNB3 GNB4 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 LOC730418 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors ADCYAP1 ADCYAP1R1 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 SCT SCTR VIP VIPR1 VIPR2 +REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis ALDOA ALDOB ALDOC ENO1 ENO2 ENO3 FBP1 FBP2 GAPDH GAPDHS GOT1 GOT2 GPI LOC642969 LOC730418 MDH1 MDH2 PC PCK1 PCK2 PFKFB1 PGAM1 PGAM2 PGK1 PRKACA PRKACB PRKACG SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 TPI1 TPI1P1 +REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism AGL ALDOA ALDOB ALDOC CALM1 CALM2 CALM3 ENO1 ENO2 ENO3 FBP1 FBP2 GAPDH GAPDHS GBE1 GOT1 GOT2 GPI GYG1 GYG2 GYS1 GYS2 LOC642969 LOC650556 LOC730418 MDH1 MDH2 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PGM1 PGM2 PHKA1 PHKA1P1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG PYGB PYGL PYGM SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 TPI1 TPI1P1 UGP2 +REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport AAAS G6PC G6PC2 G6PC3 GCK GCKR HK1 HK2 HK3 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC37A4 TPR +REACTOME_GLUCURONIDATION Genes involved in Glucuronidation SLC35D1 UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle GLS GLS2 RAB3A RIMS1 SLC17A7 SLC1A1 SLC1A6 SLC1A7 SLC38A2 SNAP25 STX1A STXBP1 SYT1 UNC13B VAMP2 +REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation CNDP2 GCLC GCLM GGCT GGT1 GGT5 GGT7 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 MGST1 MGST2 MGST3 OPLAH +REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis ACHE AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 CDIPT CDS1 CDS2 CEPT1 CHAT CHKA CHKB CHPT1 CRLS1 DGAT1 DGAT2 EPT1 ETNK1 ETNK2 GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L HADHA HADHB LCLAT1 LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 MBOAT1 MBOAT2 MBOAT7 MGLL PCYT1A PCYT1B PCYT2 PEMT PGS1 PHOSPHO1 PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLA2G6 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PNPLA2 PNPLA3 PNPLA8 PTDSS1 PTDSS2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 TAZ +REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis) AGL CALM1 CALM2 CALM3 GYG1 GYG2 LOC650556 PGM1 PGM2 PHKA1 PHKA1P1 PHKA2 PHKB PHKG1 PHKG2 PYGB PYGL PYGM +REACTOME_GLYCOLYSIS Genes involved in Glycolysis ALDOA ALDOB ALDOC ENO1 ENO2 ENO3 GAPDH GAPDHS GPI LOC642969 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PKLR PKM2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D TPI1 TPI1P1 +REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones CGA CGB CGB5 CGB8 FSHB INHA INHBA INHBB INHBC INHBE LHB TSHB +REACTOME_GLYCOSAMINOGLYCAN_METABOLISM Genes involved in Glycosaminoglycan metabolism ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CD44 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 DCN DSE EXT1 EXT2 FMOD GLB1 GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HAS1 HAS2 HAS3 HEXA HEXB HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST1P1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 IDS IDUA KERA LOC644504 LOC644691 LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PRELP SDC1 SDC2 SDC3 SDC4 SGSH SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL6 STAB2 UST VCAN +REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C CERK CTSA ENPP7 GAL3ST1 GALC GBA GBA2 GBA3 GLA GLB1 GM2A HEXA HEXB NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 UGCG +REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 CLTA CLTC CNO CPD DNAJC6 DNM2 DTNBP1 FTH1 FTL GAK HIP1R HSPA8 IGF2R LOC643454 NAPA NECAP1 OCRL PICALM PIK3C2A PLDN PUM1 RAB5C SH3D19 SH3GL2 SNAPIN SNX2 SNX5 SNX9 SORT1 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 +REACTOME_GPCR_DOWNSTREAM_SIGNALING Genes involved in GPCR downstream signaling ABR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRB1 ADRB2 ADRB3 ADRBK1 AGT AGTR1 AGTR2 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLNR APP ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CALCA CALCB CALCRL CASR CCK CCKAR CCKBR CCL16 CCL19 CCL20 CCL21 CCL25 CCL27 CCL28 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CDC42 CGA CHRM1 CHRM2 CHRM3 CHRM5 CNR1 CNR2 CRH CRHR2 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DRD1 DRD2 DRD3 DRD5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FGD1 FGD2 FGD3 FGD4 FPR1 FPR2 FPR3 FSHB FSHR GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPBAR1 GPER GPR132 GPR17 GPR18 GPR4 GPR44 GPR55 GPR65 GPR68 GPRC6A GRK5 GRP GRPR HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IL8 INSL3 INSL5 ITPR2 ITPR3 ITSN1 KALRN KISS1 KISS1R KNG1 LHB LHCGR LOC652222 LOC652692 LOC653879 LOC730002 LOC730221 LOC730335 LOC730413 LOC730421 LOC730808 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCF2 MCHR1 MCHR2 MGLL MLN MLNR MTNR1A MTNR1B NET1 NGEF NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY5R NTS NTSR1 NTSR2 OBSCN OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AD1 OR10AG1 OR10C1 OR10G2 OR10G3 OR10G4 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J5 OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR14A16 OR14C36 OR14J1 OR14K1 OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1F1 OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A42 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AK2 OR2B11 OR2B2 OR2B3 OR2B6 OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2V2 OR2W1 OR2W3 OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A5 OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C6 OR4D1 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E2 OR4F15 OR4F16 OR4F17 OR4F29 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N3P OR4N4 OR4N5 OR4P4 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F2 OR51G1 OR51G2 OR51I1 OR51I2 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A5 OR52B4 OR52B6 OR52D1 OR52E2 OR52E4 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52R1 OR52W1 OR56A1 OR56A3 OR56A4 OR56B1 OR56B4 OR5A1 OR5A2 OR5AC2 OR5AK2 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5L1 OR5L2 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6F1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 OXER1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLXNB1 PMCH PNOC POMC PPBP PPY PPYR1 PREX1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PROK1 PROKR1 PROKR2 PTAFR PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAC1 RAC2 RAMP1 RAMP2 RAMP3 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS11 RGS12 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RHOA RHOB RHOC RHOG RLN2 RLN3 ROCK1 ROCK1P1 ROCK2 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SOS1 SOS2 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR UTS2 UTS2D UTS2R VAV1 VAV3 VIP VIPR1 VIPR2 XCL1 XCL2 XCR1 +REACTOME_GPCR_LIGAND_BINDING Genes involved in GPCR ligand binding ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 ANXA1 APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CALCA CALCB CALCRL CASR CCBP2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL1P1 CD55 CD97 CGA CHRM1 CHRM2 CHRM3 CHRM5 CNR1 CNR2 CRH CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 CYSLTR1 CYSLTR2 DARC DHH DRD1 DRD2 DRD3 DRD5 EDN1 EDN2 EDN3 EDNRA EDNRB EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPBAR1 GPER GPR132 GPR17 GPR18 GPR39 GPR4 GPR44 GPR55 GPR65 GPR68 GPR77 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 GRP GRPR HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH IL8 INSL3 INSL5 KISS1 KISS1R KNG1 LHB LHCGR LOC649279 LOC652222 LOC652292 LOC653879 LOC728830 LOC730002 LOC730413 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MTNR1A MTNR1B NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY5R NTS NTSR1 NTSR2 O3FAR1 OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PPYR1 PRLH PRLHR PROK1 PROKR1 PROKR2 PTAFR PTCH1 PTCH2 PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RGR RHO RLN2 RLN3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHH SMO SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TBXA2R TRH TRHR TSHB TSHR UTS2 UTS2D UTS2R VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 +REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade AKT1 AKT2 AKT3 CDC42 COL1A1 COL1A2 FCER1G FYN LAT LCK LCP2 LYN PDPK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLCG2 PRKCZ RAC1 RAC2 RHOA RHOB RHOG SYK VAV1 VAV3 +REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling BTC CDK1 EGF EGFR ERBB2 ERBB4 EREG GRB2 HBEGF HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS NRG1 NRG2 NRG4 RAF1 SOS1 YWHAB +REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins APBB1IP FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PTK2 RAP1A RAP1B SOS1 SRC TLN1 VWF +REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling ADAM17 CISH CSH1 GH1 GH2 GHR IRS1 IRS2 JAK2 LYN MAPK1 MAPK3 PRL PRLR PTPN1 PTPN6 SH2B1 SOCS1 SOCS2 SOCS3 STAT1 STAT3 STAT5A STAT5B +REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport A2M ABCA1 ABCG1 ALB AMN APOA1 APOC2 APOC3 APOE BMP1 CETP CUBN LCAT PLTP SCARB1 +REACTOME_HEMOSTASIS Genes involved in Hemostasis A2M ABCC4 ABL1 ACTN1 ACTN2 ACTN4 ADRA2A ADRA2B AK3 AKAP1 AKAP10 AKT1 AKT2 AKT3 ALB ALDOA AMICA1 ANGPT1 ANGPT2 ANGPT4 APBB1IP APOA1 APOB APP ARRB1 ARRB2 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 BCAR1 BRPF3 BSG C1QBP CABLES1 CABLES2 CALM1 CALM2 CALM3 CALU CAP1 CAPZA1 CAPZA2 CAV1 CBX5 CD2 CD36 CD47 CD48 CD58 CD63 CD9 CDC42 CDK2 CDK5 CFD CFL1 CLU COL1A1 COL1A2 CREBBP CRK CSK CXADR DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK8 DOCK9 DOK2 EGF EHD1 EHD2 EP300 ESAM F10 F11 F11R F12 F13A1 F13B F2 F2R F2RL2 F2RL3 F3 F5 F7 F8 F9 FCER1G FGA FGB FGG FGR FIGF FN1 FYN GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GP1BA GP1BB GP5 GP9 GRB14 GRB2 GRB7 GUCY1A2 GUCY1A3 GUCY1B3 H3F3A H3F3AP5 H3F3AP6 H3F3B HABP4 HBB HBD HBE1 HBG2 HDAC1 HDAC2 HGF HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HMG20B HRAS HRG HSPA5 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IRF1 IRF2 IRF3 IRF7 ITGA2 ITGA2B ITGA3 ITGA5 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITPK1 ITPR2 ITPR3 JAK2 JAM2 JAM3 JMJD1C KCNMB1 KCNMB2 KCNMB3 KCNMB4 KDM1A KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 KLKB1 KNG1 KRAS L1CAM LAMP2 LAT LCK LCP2 LEFTY2 LOC128192 LOC131691 LOC441511 LOC643997 LOC652612 LOC654188 LOC727848 LOC730221 LOC730335 LOC730418 LOC731820 LRP8 LYN MAFF MAFG MAFK MAG MAPK1 MAPK14 MAPK3 MERTK MFN1 MFN2 MGLL MMP1 MMRN1 MPL MRVI1 MYB NFE2 NOS1 NOS2 NOS3 NRAS OLR1 ORAI1 P2RX1 P2RY1 P2RY12 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE6A PDE6B PDE6G PDE9A PDGFA PDGFB PDPK1 PECAM1 PF4 PF4V1 PFN1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLAT PLAU PLAUR PLCG1 PLCG2 PLEK PLG POTEM PPBP PPIA PPIAP22 PPIAP8 PPIL2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRCP PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ PRKG1 PRKG2 PROC PROS1 PSAP PTGIR PTK2 PTPN1 PTPN6 RAB5A RAC1 RAC2 RACGAP1 RAD51B RAD51C RAF1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RCOR1 RHOA RHOB RHOG SCG3 SELL SELP SERPINA1 SERPINB2 SERPINC1 SERPINE1 SERPINF2 SERPING1 SH2B1 SH2B2 SH2B3 SHC1 SIN3A SIRPA SIRPG SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SOD1 SOS1 SPARC SPN SRC SRGN STIM1 STX4 STXBP3 SYK TBXA2R TEK TF TFPI TGFB1 TGFB2 TGFB3 THBD THBS1 THPO TIMP1 TLN1 TMSB4X TP53 TREM1 TRPC3 TRPC6 TRPC7 TUBA4A VAV1 VAV3 VCL VEGFA VEGFB VEGFC VPS45 VWF WDR1 WEE1 YES1 YWHAZ ZFPM1 ZFPM2 ZFYVE20 +REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 DCN EXT1 EXT2 GLB1 GLCE GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB GXYLT1 GXYLT2 HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST1P1 HS6ST2 HS6ST3 HSPG2 IDS IDUA NAGLU NCAN NDST1 NDST2 NDST3 NDST4 SDC1 SDC2 SDC3 SDC4 SGSH VCAN +REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 LOC732445 +REACTOME_HIV_INFECTION Genes involved in HIV Infection AAAS AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOBEC3G ARF1 ATP6V1H B2M BANF1 BTRC CCNH CCNT1 CCNT2 CCR5 CD247 CD28 CD4 CD8B CDK7 CDK9 COBRA1 CTDP1 CUL5 CXCR4 DOCK2 ELL ELMO1 ERCC2 ERCC3 FEN1 FYN GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 HCK HLA-A HLA-K HMGA1 KPNA1 KPNB1 LCK LIG1 LIG4 LOC128192 LOC131691 LOC389901 LOC440577 LOC643997 LOC645870 LOC652826 LOC652857 LOC654188 MNAT1 NCBP1 NCBP2 NMT1 NMT2 NPM1 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PACS1 PAK2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PPIA PPIAP22 PPIAP8 PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAC1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RBX1 RCC1 RDBP RNGTT RNMT RPS27A RPS27AP11 SEH1L SKP1 SLC25A4 SLC25A5 SLC25A6 SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L TPR TSG101 UBA52 VPS28 VPS37A VPS37B VPS37C VPS37D WHSC2 XPO1 XRCC4 XRCC5 XRCC6 +REACTOME_HIV_LIFE_CYCLE Genes involved in HIV Life Cycle AAAS BANF1 CCNH CCNT1 CCNT2 CCR5 CD4 CDK7 CDK9 COBRA1 CTDP1 CXCR4 ELL ERCC2 ERCC3 FEN1 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 HMGA1 LIG1 LIG4 LOC128192 LOC131691 LOC389901 LOC643997 LOC645870 LOC652857 LOC654188 MNAT1 NCBP1 NCBP2 NMT1 NMT2 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PPIA PPIAP22 PPIAP8 PSIP1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 RDBP RNGTT RNMT RPS27A RPS27AP11 SEH1L SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L TPR TSG101 UBA52 VPS28 VPS37A VPS37B VPS37C VPS37D WHSC2 XPO1 XRCC4 XRCC5 XRCC6 +REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks ATM BRCA1 BRCA2 BRIP1 H2AFX LIG1 LOC651610 MDC1 MRE11A NBN RAD50 RAD51 RAD52 RPA1 RPA2 RPA3 TP53BP1 +REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors CGA FSHB FSHR GNRH1 GNRH2 GNRHR LHB LHCGR TSHB TSHR +REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis ABHD5 CAV1 FABP4 LIPE LOC730418 MGLL PLIN1 PPP1CA PPP1CB PPP1CC PRKACA PRKACB PRKACG +REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors AAAS AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOBEC3G ARF1 ATP6V1H B2M BANF1 BTRC CCNT1 CD247 CD28 CD4 CD8B CDK9 CUL5 DOCK2 ELMO1 FYN HCK HLA-A HLA-K HMGA1 KPNA1 KPNB1 LCK LOC128192 LOC131691 LOC440577 LOC643997 LOC645870 LOC652826 LOC654188 NPM1 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PACS1 PAK2 POM121 PPIA PPIAP22 PPIAP8 PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAC1 RAE1 RAN RANBP1 RANBP2 RANGAP1 RBX1 RCC1 RPS27A RPS27AP11 SEH1L SKP1 SLC25A4 SLC25A5 SLC25A6 TCEB1 TCEB1P3 TCEB2 TPR UBA52 XPO1 +REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis AGRN EXT1 EXT2 GLCE GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST1P1 HS6ST2 HS6ST3 HSPG2 NDST1 NDST2 NDST3 NDST4 SDC1 SDC2 SDC3 SDC4 +REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation AGRN GLB1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB HPSE HPSE2 HSPG2 IDS IDUA NAGLU SDC1 SDC2 SDC3 SDC4 SGSH +REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism ABCC5 CD44 GUSB HAS1 HAS2 HAS3 HEXA HEXB HMMR HYAL1 HYAL2 LYVE1 SLC9A1 STAB2 +REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation CD44 GUSB HEXA HEXB HMMR HYAL1 HYAL2 LYVE1 SLC9A1 STAB2 +REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1 CD14 CHUK IKBKB IKBKG LY96 RIPK1 TICAM1 TICAM2 TLR3 TLR4 +REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling BTRC CHUK CUL1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 MAP2K1 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MYD88 NOD1 NOD2 PELI1 PELI2 PELI3 RBX1 RIPK2 SKP1 SQSTM1 TAB1 TAB2 TAB3 TMEM189-UBE2V1 TNIP2 TOLLIP TRAF6 UBE2N +REACTOME_IL_2_SIGNALING Genes involved in Interleukin-2 signaling CDK1 CSF2 CSF2RA CSF2RB GAB2 GRB2 HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPPL1 JAK1 JAK2 JAK3 KRAS LCK MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTK2B PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B SYK YWHAB +REACTOME_IL_3_5_AND_GM_CSF_SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling BLNK CBL CRK CRKL CSF2 CSF2RA CSF2RB FYN GAB2 GRB2 HCK HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPPL1 JAK1 JAK2 JAK3 LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACB PTPN6 RAPGEF1 SHC1 SOS1 STAT5A STAT5B SYK TEC VAV1 YES1 YWHAZ +REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling CBL IL6 IL6R IL6ST JAK1 JAK2 LOC649891 SOCS3 STAT1 STAT3 TYK2 +REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling HGF IL2RG IL7 IL7R JAK1 JAK3 PIK3R1 PIK3R2 PIK3R3 STAT5A STAT5B +REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling CSF2 CSF2RA CSF2RB GAB2 GRB2 HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPPL1 JAK1 JAK2 JAK3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN6 SHC1 SOS1 +REACTOME_IMMUNE_SYSTEM Genes involved in Immune System AAAS ACTR1A ACTR1B ADAM17 ADAR AGER AIM2 AKT1 AKT1S1 AKT2 AKT3 AMICA1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APP ARF1 ARIH1 ARIH2 ART1 ASB1 ASB11 ASB12 ASB13 ASB15 ASB16 ASB17 ASB2 ASB3 ASB4 ASB5 ASB6 ASB7 ASB8 ASB9 ATF1 ATF2 ATG12 ATG5 ATG7 B2M BAD BCL10 BCL2 BCL2L1 BIRC2 BIRC3 BLK BLMH BLNK BTK BTLA BTRC C1QA C1QB C1QC C1S C2 C3 C4A C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CALM1 CALM2 CALM3 CALR CAMK2A CAMK2B CAMK2D CANX CAPZA1 CAPZA2 CARD11 CARD9 CASP1 CASP10 CASP2 CASP4 CASP8 CASP9 CBL CBLB CCR2 CCR6 CD14 CD160 CD180 CD19 CD200R1 CD207 CD226 CD247 CD274 CD28 CD34 CD36 CD3D CD3E CD3G CD4 CD40 CD40LG CD44 CD46 CD55 CD74 CD79A CD79B CD80 CD81 CD86 CD8A CD8B CD96 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDC34 CDC42 CDH1 CDK1 CDKN1A CDKN1B CFB CFD CFH CFHR3 CFI CHUK CIITA CISH CLTA CLTC CNPY3 CR1 CREB1 CREBBP CRK CRKL CRP CRTAM CSF2 CSF2RA CSF2RB CSH1 CSK CTLA4 CTSA CTSB CTSC CTSD CTSF CTSH CTSK CTSL1 CTSL2 CTSO CTSS CUL1 CUL2 CUL3 CUL5 CUL7 CXADR CYBA CYBB CYLD DAK DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DDOST DDX58 DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B DET1 DHX58 DNM1 DNM2 DTX3L DUSP3 DUSP4 DUSP6 DUSP7 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DZIP3 ECSIT EEA1 EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 ELK1 ENAH EP300 ERAP1 EVL FADD FBXO17 FBXO2 FBXO27 FBXO3 FBXO4 FBXO44 FBXO6 FBXW11 FBXW7 FBXW8 FCGR1A FCGR1B FCGR2B FCGR3A FLNB FOS FOXO1 FOXO3 FOXO4 FYB FYN GAB2 GAN GBP1 GBP2 GBP4 GBP5 GBP6 GBP7 GH1 GH2 GHR GRAP2 GRB2 GSK3A HCK HCST HECTD3 HERC2 HERC5 HGF HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 HLA-F HLA-G HLA-K HMGB1 HRAS HSP90AB1 HSP90B1 HSPA5 HUWE1 ICAM1 ICAM2 ICAM3 ICAM4 ICOS ICOSLG IFI27 IFI35 IFI6 IFIH1 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IKBKB IKBKE IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPPL1 IP6K2 IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 IRS1 IRS2 ISG15 ISG20 ITGAL ITGAV ITGB1 ITGB2 ITGB5 ITGB7 ITK ITPR2 ITPR3 JAK1 JAK2 JAK3 JUN KEAP1 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIFAP3 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR3DL1 KIR3DL2 KLC1 KLC2 KLC3 KLC4 KLHL13 KLHL20 KLHL9 KLRC1 KLRD1 KLRK1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNB1 KRAS LAT LBP LCK LCP2 LGALS3 LGMN LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LNPEP LOC144383 LOC441019 LOC644006 LOC644816 LOC646626 LOC646981 LOC647654 LOC648998 LOC649620 LOC649891 LOC650621 LOC650832 LOC651536 LOC651763 LOC652578 LOC652626 LOC652826 LOC653879 LOC729120 LOC729523 LOC730418 LOC730594 LOC731049 LOC731066 LOC731292 LOC731429 LOC731949 LRR1 LRRC41 LRSAM1 LY86 LY96 LYN MALT1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K14 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAP1 MAPKAPK2 MAPKAPK3 MASP1 MASP2 MAVS MBL2 MDM2 MEF2A MEF2C MEFV MKRN1 MLST8 MRC1 MRC2 MT2A MTOR MX1 MX2 MYD88 NCAM1 NCF2 NCF4 NCK1 NEDD4 NFKB2 NFKBIA NFKBIB NFKBIE NLRC4 NLRC5 NLRP1 NLRP3 NLRX1 NOD1 NOD2 NPEPPS NR4A1 NRAS NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL ORAI1 OSBPL1A OTUD5 P2RX7 PAG1 PAK1 PAK2 PANX1 PARK2 PCBP2 PDCD1 PDCD1LG2 PDIA3 PDPK1 PELI1 PELI2 PELI3 PHLPP1 PIAS1 PIK3AP1 PIK3C3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIN1 PJA1 PJA2 PLCG1 PLCG2 PML POM121 PPM1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKACA PRKACB PRKACG PRKCB PRKCD PRKCQ PRKCSH PRKG1 PRL PRLR PROS1 PRSS2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PSTPIP1 PTAFR PTEN PTK2B PTPN1 PTPN2 PTPN6 PTPRC PVR PVRL2 PYCARD RAB7A RAC1 RACGAP1 RAE1 RAET1E RAF1 RANBP2 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF1 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RASGRP3 RBCK1 RBX1 RCHY1 REL RELA RICTOR RILP RIPK1 RIPK2 RIPK3 RNASEL RNF123 RNF125 RNF135 RNF138 RNF144B RNF182 RNF220 RNF25 RNF34 RNF4 RNF41 RNF6 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 S100A12 S100B SAA1 SAE1 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SEH1L SELL SH2B1 SH3GL2 SH3KBP1 SHC1 SIGIRR SIKE1 SIPA1 SKP1 SKP2 SMURF1 SMURF2 SOCS1 SOCS2 SOCS3 SOS1 SP100 SPSB1 SPSB2 SPSB4 SPTBN2 SQSTM1 SRC STAT1 STAT2 STAT3 STAT5A STAT5B STIM1 STUB1 SUMO1 SYK TAB1 TAB2 TAB3 TANK TAP1 TAP2 TAX1BP1 TBK1 TCEB1 TCEB1P3 TCEB2 TEC THEM4 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMEM189-UBE2V1 TNFAIP3 TNFRSF14 TNIP2 TOLLIP TPP2 TPR TRAF2 TRAF3 TRAF6 TRAT1 TRIB3 TRIM11 TRIM21 TRIM25 TRIM32 TRIM36 TRIM37 TRIM63 TRIM9 TRIP12 TSC2 TXN TXNIP TYK2 TYROBP UBA1 UBA2 UBA3 UBA5 UBA52 UBA6 UBA7 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2HP1 UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE4A UBOX5 UBR1 UBR2 UBR4 ULBP1 ULBP2 ULBP3 UNC93B1 UNC93B2 UNC93B6 USP18 VASP VAV1 VCAM1 VHL VPRBP WAS WSB1 WWP1 XAF1 YES1 YWHAB YWHAZ ZAP70 ZBP1 ZBTB16 ZFYVE20 +REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell AMICA1 B2M C3 CD160 CD19 CD200R1 CD226 CD247 CD34 CD3D CD3E CD3G CD40 CD40LG CD81 CD8A CD8B CD96 CDH1 CRTAM CXADR FCGR2B FCGR3A HCST HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K ICAM1 ICAM2 ICAM3 ICAM4 IFITM1 ITGAL ITGB1 ITGB2 ITGB7 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DS1 KIR2DS2 KIR3DL1 KIR3DL2 KLRC1 KLRD1 KLRK1 LILRA1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LOC651536 LOC652578 LOC652626 LOC653879 LOC731066 PVR PVRL2 RAET1E SELL TYROBP ULBP1 ULBP2 ULBP3 VCAM1 +REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation CDX2 CTNNB1 DPP4 FFAR1 GATA4 GCG GIP GNB3 GNG13 GPR119 GRP ISL1 LEP LOC653566 O3FAR1 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +REACTOME_INFLAMMASOMES Genes involved in Inflammasomes AIM2 APP BCL2 BCL2L1 CASP1 HSP90AB1 LOC644816 MEFV NLRC4 NLRP1 NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD TXN TXNIP +REACTOME_INFLUENZA_LIFE_CYCLE Genes involved in Influenza Life Cycle AAAS CALR CANX CLTA CLTC DNAJC3 FAM153A FAU GRSF1 GTF2F1 GTF2F2 HSP90AA1 HSPA1B IPO5 KPNA1 KPNB1 LOC641895 LOC646184 LOC647074 LOC649602 LOC651825 LOC651894 LOC653881 LOC730343 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP2 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 SEH1L TPR UBA52 XPO1 +REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication DNAJC3 FAM153A FAU GRSF1 GTF2F1 GTF2F2 HSP90AA1 IPO5 LOC641895 LOC646184 LOC647074 LOC649602 LOC651825 LOC651894 LOC653881 LOC730343 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 UBA52 +REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline ADCY5 ADCY6 ADRA2A CACNB2 CACNB3 GNAI1 GNAI2 GNAO1 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 +REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 E2F1 LOC441488 POLA1 POLA2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 RB1 TFDP1 +REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 LOC647654 LOC649620 LOC650621 LOC651763 LOC730594 MAD2L1 UBE2C UBE2D1 UBE2E1 +REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 +REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement C1QA C1QB C1QC C1S C2 C3 C4A CFB CFD CRP LOC651536 LOC653879 LOC731066 MASP1 MASP2 MBL2 +REACTOME_INNATE_IMMUNE_SYSTEM Genes involved in Innate Immune System AGER AIM2 APP ART1 ATF1 ATF2 ATG12 ATG5 BCL2 BCL2L1 BIRC2 BIRC3 BTK C1QA C1QB C1QC C1S C2 C3 C4A C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CAPZA1 CAPZA2 CARD9 CASP1 CASP10 CASP2 CASP4 CASP8 CASP9 CCR2 CCR6 CD14 CD180 CD4 CD46 CD55 CDK1 CFB CFD CFH CFHR3 CFI CHUK CNPY3 CR1 CREB1 CREBBP CRP CTSB CTSK CTSL1 CTSS CYLD DAK DDOST DDX58 DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB110 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130 DEFB131 DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B DHX58 DNM1 DNM2 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT EEA1 ELK1 EP300 FADD FOS HERC5 HMGB1 HSP90AB1 HSP90B1 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF7 ISG15 JUN LBP LGALS3 LGMN LOC644816 LOC650832 LOC651536 LOC653879 LOC729523 LOC731066 LOC731949 LY86 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MASP1 MASP2 MAVS MBL2 MEF2A MEF2C MEFV MYD88 NFKB2 NFKBIA NFKBIB NLRC4 NLRC5 NLRP1 NLRP3 NLRX1 NOD1 NOD2 OTUD5 P2RX7 PANX1 PCBP2 PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PIN1 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKCSH PROS1 PRSS2 PSTPIP1 PYCARD RELA RIPK1 RIPK2 RIPK3 RNF125 RNF135 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR SIKE1 TAB1 TAB2 TAB3 TANK TAX1BP1 TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMEM189-UBE2V1 TNFAIP3 TRAF2 TRAF3 TRAF6 TRIM25 TXN TXNIP UBA52 UBA7 UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 UBE2N UNC93B1 UNC93B2 UNC93B6 ZBP1 ZFYVE20 +REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H INS INSR TCIRG1 +REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE Genes involved in Insulin receptor signalling cascade AKT2 CAB39 CAB39L CDK1 CRK DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB10 GRB2 HRAS INS INSR IRS1 IRS2 KL KLB KRAS LOC644462 LOC729120 LOC730244 MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 YWHAB +REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing CPE ERO1L EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC8 INS KIF5B LOC644556 MYO5A PCSK1 PCSK2 RAB27A SLC30A5 SLC30A7 SNAP25 STX1A VAMP2 +REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism ABCC8 ACACA ACACB ACLY ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A AGPAT1 AKAP5 CACNA1A CACNB2 CACNB3 CDX2 CHRM3 CTNNB1 DPP4 FASN FFAR1 GATA4 GCG GCGR GIP GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAO1 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPR119 GRP INS IQGAP1 ISL1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 LEP LOC653566 LOC730413 LOC730418 MARCKS MLX MLXIPL O3FAR1 PAX6 PCSK1 PFKFB1 PKLR PLCB1 PLCB2 PLCB3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAP1B RAPGEF3 RAPGEF4 SEC11A SEC11C SLC25A4 SLC25A5 SLC25A6 SLC2A1 SLC2A2 SNAP25 SPCS1 SPCS2 SPCS3 STK11 STX1A STXBP1 SYT5 TALDO1 TKT VAMP2 +REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus BANF1 HMGA1 LIG4 LOC128192 LOC131691 LOC389901 LOC643997 LOC645870 LOC654188 PPIA PPIAP22 PPIAP8 PSIP1 XRCC4 XRCC5 XRCC6 +REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling AKT1 APBB1IP BCAR1 CRK CSK FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK TLN1 VWF +REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions AKT1 AMICA1 APBB1IP BCAR1 BSG CDH1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 CRK CSK F11R FBN1 FGA FGB FGG FN1 GRB2 IBSP ICAM1 ICAM2 ICAM3 ICAM4 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA5 ITGA8 ITGA9 ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JAM2 JAM3 LAMA1 LAMA2 LAMA5 LAMB1 LAMB2 LAMC1 PDPK1 PECAM1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SPP1 SRC SYK THBS1 TLN1 TNC VCAM1 VTN VWF +REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins ANK1 ANK3 KCNQ2 KCNQ3 L1CAM LOC650400 LOC731231 NRCAM SCN1B SCN2A SCN2B SCN3B SCN4A SCN5A SCN7A SCN8A SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 +REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins AAAS BANF1 HMGA1 KPNA1 LOC645870 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 PSIP1 RAE1 RANBP2 SEH1L SLC25A4 SLC25A5 SLC25A6 TPR +REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling ADAR EGR1 GBP2 HLA-A HLA-B HLA-C HLA-F HLA-G HLA-K IFI27 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 JAK1 LOC144383 MX1 MX2 OAS1 OAS2 OAS3 OASL PSMB8 PTPN1 PTPN6 RNASEL SOCS1 SOCS3 STAT1 STAT2 TYK2 USP18 XAF1 +REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling B2M CAMK2A CAMK2B CAMK2D CD44 CIITA FCGR1A FCGR1B GBP1 GBP2 GBP4 GBP5 GBP6 GBP7 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 HLA-F HLA-G HLA-K ICAM1 IFNG IFNGR1 IFNGR2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 JAK1 JAK2 LOC441019 LOC646981 MT2A NCAM1 OAS1 OAS2 OAS3 OASL PIAS1 PML PRKCD PTAFR PTPN1 PTPN2 PTPN6 SOCS1 SOCS3 SP100 STAT1 SUMO1 VCAM1 +REACTOME_INTERFERON_SIGNALING Genes involved in Interferon Signaling AAAS ADAR ARIH1 B2M CAMK2A CAMK2B CAMK2D CD44 CIITA DDX58 EGR1 EIF2AK2 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4E2 EIF4E3 EIF4G1 EIF4G2 EIF4G3 FCGR1A FCGR1B FLNB GBP1 GBP2 GBP4 GBP5 GBP6 GBP7 HERC5 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 HLA-F HLA-G HLA-K ICAM1 IFI27 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 JAK1 JAK2 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNB1 LOC144383 LOC441019 LOC646981 MAPK3 MT2A MX1 MX2 NCAM1 NEDD4 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 OAS1 OAS2 OAS3 OASL PIAS1 PIN1 PLCG1 PML POM121 PPM1B PRKCD PSMB8 PTAFR PTPN1 PTPN2 PTPN6 RAE1 RANBP2 RNASEL RPS27A RPS27AP11 SEH1L SOCS1 SOCS3 SP100 STAT1 STAT2 SUMO1 TPR TRIM25 TYK2 UBA52 UBA7 UBE2E1 UBE2L6 UBE2N USP18 VCAM1 XAF1 +REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway A2M C1QBP F10 F11 F12 F2 F8 F9 GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PRCP SERPING1 VWF +REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis AKT1 APAF1 BAD BAK1 BAX BBC3 BCL2 BCL2L1 BCL2L11 BID BMF CASP3 CASP7 CASP8 CASP9 CYCS DIABLO DYNLL1 DYNLL2 E2F1 GZMB LOC441488 MAPK8 NMT1 PMAIP1 PPP3R1 TFDP1 TP53 XIAP YWHAB +REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels ABCC8 ABCC9 GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 +REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport ARHGEF9 ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B3 ATP8B4 ATP9A ATP9B FXYD2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GLRA1 GLRA2 GLRA3 GLRB HTR3A HTR3B HTR3C LOC644732 +REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B3 ATP8B4 ATP9A ATP9B FXYD2 LOC644732 +REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors CALM1 CALM2 CALM3 DLG1 DLG3 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD +REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex CHUK IKBKB IKBKG IRAK1 PELI1 PELI2 PELI3 TMEM189-UBE2V1 TRAF6 UBE2N +REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IRAK2 MAP3K7 RPS27A RPS27AP11 TAB1 TAB2 TAB3 TRAF6 UBA52 +REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport ABCG2 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CP CYBRD1 FLVCR1 FTH1 FTL HEPH HMOX1 HMOX2 MCOLN1 SLC40A1 SLC46A1 STEAP3 TCIRG1 TF TFRC +REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IKBKG IRAK1 IRAK2 MAP2K4 MAP2K7 MAP3K7 MAPK10 MAPK8 MAPK9 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TRAF6 +REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis ACAN B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CHST1 CHST2 CHST5 CHST6 FMOD KERA LUM OGN OMD PRELP ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL6 +REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation ACAN FMOD GLB1 GNS HEXA HEXB KERA LUM OGN OMD PRELP +REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism ACAN B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 CHST1 CHST2 CHST5 CHST6 FMOD GLB1 GNS HEXA HEXB KERA LUM OGN OMD PRELP ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL6 +REACTOME_KINESINS Genes involved in Kinesins KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF9 KIFAP3 KIFC1 KLC1 KLC2 KLC3 KLC4 RACGAP1 +REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions ALCAM ANK1 ANK3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CD24 CLTA CLTC CNTN1 CNTN2 CNTN6 CNTNAP1 CSNK2A1 CSNK2A2 CSNK2B DCX DLG1 DLG3 DNM1 DNM2 DPYSL2 EGFR EZR FGFR1 ITGA1 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 KCNQ2 KCNQ3 KIAA1598 KIF4A KIF4B L1CAM LAMA1 LAMB1 LAMC1 LOC650400 LOC731231 MAP2K1 MAP2K2 MAPK1 MAPK3 MSN NCAM1 NCAN NRCAM NRP1 NRP2 NUMB PAK1 RAC1 RANBP9 RDX RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SCN1B SCN2A SCN2B SCN3B SCN4A SCN5A SCN7A SCN8A SDCBP SH3GL2 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC STIP1 +REACTOME_LAGGING_STRAND_SYNTHESIS Genes involved in Lagging Strand Synthesis DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle AAAS CCNH CCNT1 CCNT2 CDK7 CDK9 COBRA1 CTDP1 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 NCBP1 NCBP2 NMT1 NMT2 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP1 RANBP2 RANGAP1 RCC1 RDBP RNGTT RNMT RPS27A RPS27AP11 SEH1L SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L TPR TSG101 UBA52 VPS28 VPS37A VPS37B VPS37C VPS37D WHSC2 XPO1 +REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CAMP CYBA CYBB LOC648998 LOC728320 LTF NCF2 NCF4 NOS1 NOS2 NOS3 SLC11A1 TCIRG1 +REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport ARHGEF9 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GLRA1 GLRA2 GLRA3 GLRB HTR3A HTR3B HTR3C +REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport A2M ABCA1 ABCG1 ABCG5 ABCG8 ABHD5 ALB AMN APOA1 APOA2 APOA5 APOB APOC2 APOC3 APOE BMP1 CAV1 CETP CLPS CUBN FABP4 HSPG2 LCAT LDLR LDLRAP1 LIPC LIPE LOC730418 LPA LPL MGLL MTTP P4HB PLIN1 PLTP PNLIP PNLIPRP2 PPP1CA PPP1CB PPP1CC PRKACA PRKACB PRKACG SAR1B SCARB1 SDC1 +REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism A2M ABCA1 ABCG1 ALB AMN APOA1 APOA2 APOA5 APOB APOC2 APOC3 APOE BMP1 CETP CUBN HSPG2 LCAT LDLR LDLRAP1 LIPC LPA LPL MTTP P4HB PLTP SAR1B SCARB1 SDC1 +REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes ACTR1A AKAP9 ALMS1 AZI1 CDK1 CDK5RAP2 CENPJ CEP135 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 LOC440917 LOC730418 MAPRE1 NEDD1 NEK2 NINL OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBBP2 TUBG1 YWHAE YWHAG +REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 ARF1 ARRB1 BLOC1S1 CLTA CLTC CTSZ DNAJC6 DNASE2 DNM2 GNS HSPA8 M6PR SH3GL2 TXNDC5 VAMP2 VAMP7 VAMP8 +REACTOME_M_G1_TRANSITION Genes involved in M/G1 Transition CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 E2F1 E2F2 E2F3 GMNN LOC645084 LOC652826 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPA1 RPA2 RPA3 RPA4 RPS27A RPS27AP11 UBA52 +REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE Genes involved in MAP kinase activation in TLR cascade ATF1 ATF2 CDK1 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS IKBKG IRAK1 IRAK2 JUN LOC650832 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RIPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 TAB1 TAB2 TAB3 TRAF6 +REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases ATF1 ATF2 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +REACTOME_MEIOSIS Genes involved in Meiosis ACD ATM ATR BLM BRCA1 BRCA2 CDK2 CDK4 DIDO1 DMC1 FKBP6 H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HSPA2 LMNA LMNB1 LOC648152 LOC651610 LOC651921 LOC731820 MLH1 MLH3 MND1 MRE11A MSH4 MSH5 NBN POT1 PRDM9 RAD21 RAD50 RAD51 RAD51C RBBP8 REC8 RPA1 RPA2 RPA3 SMC1A SMC1B SMC3 SPO11 STAG1 STAG2 STAG3 SUN2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TEX15 TINF2 TOP3A UBE2I +REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination ATM BLM BRCA1 BRCA2 CDK2 CDK4 DMC1 H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 LOC651610 LOC731820 MLH1 MLH3 MND1 MRE11A MSH4 MSH5 NBN PRDM9 RAD50 RAD51 RAD51C RBBP8 RPA1 RPA2 RPA3 SPO11 TEX15 TOP3A +REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis ACD ATR BRCA1 DIDO1 FKBP6 H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HSPA2 LMNA LMNB1 LOC648152 LOC651921 POT1 RAD21 REC8 SMC1A SMC1B SMC3 STAG1 STAG2 STAG3 SUN2 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TINF2 UBE2I +REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins NMT2 RPS27A RPS27AP11 TSG101 UBA52 VPS28 VPS37A VPS37B VPS37C VPS37D +REACTOME_MEMBRANE_TRAFFICKING Genes involved in Membrane Trafficking AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2M1 AP3B1 AP3S1 AP4B1 AP4E1 ARCN1 ARF1 ARFGAP1 ARRB1 BLOC1S1 BLOC1S3 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CLTA CLTB CLTC CLTCL1 CNO COPA COPB1 COPB2 COPE COPG COPZ1 CPD CTSZ DAB2 DNAJC6 DNASE2 DNM1 DNM2 DTNBP1 FTH1 FTL GAK GBF1 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD4 GNS HGS HIP1R HSPA8 IGF2R LOC643454 M6PR MYO6 NAPA NECAP1 OCRL PICALM PIK3C2A PLDN PREB PUM1 RAB5C RPS27A RPS27AP11 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SH3D19 SH3GL2 SNAP23 SNAPIN SNF8 SNX2 SNX5 SNX9 SORT1 SRC STAM STAM2 STX4 TBC1D8B TFRC TGOLN2 TJP1 TPD52 TPD52L1 TSG101 TXNDC5 UBA52 VAMP2 VAMP7 VAMP8 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D VPS4A VPS4B VTA1 YIPF6 +REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives AADAT AANAT AASS ACAD8 ACADSB ACAT1 ACMSD ADC ADI1 AFMID AGMAT AGXT AGXT2 AHCY ALDH18A1 ALDH4A1 ALDH6A1 ALDH7A1 ALDH9A1 AMD1 AMDHD1 APIP ARG1 ARG2 ASL ASNS ASS1 AUH AZIN1 BBOX1 BCAT1 BCAT2 BCKDHA BCKDHB BHMT CBS CCBL1 CCBL2 CDO1 CGA CGB CGB5 CGB8 CKB CKM CKMT1A CKMT1B CKMT2 CNDP2 CPS1 CSAD CTH DAO DBH DBT DDC DIO1 DIO2 DIO3 DLD DLST ENOPH1 ETHE1 FAH FSHB FTCD GAMT GATM GCDH GCLC GCLM GLS GLS2 GLUD1 GLUL GOT1 GOT2 GPT GPT2 GRHPR GSTZ1 HAAO HAL HAO1 HDC HGD HIBADH HIBCH HPD HSD17B10 IDO1 IDO2 INHA INHBA INHBB INHBC INHBE IVD IYD KMO KYNU LHB LOC643554 LOC648605 LOC652826 LOC731026 MAT1A MAT2A MAT2B MCCC1 MCCC2 MRI1 MTAP MTR NAGS NQO1 OAT OAZ1 OAZ2 OAZ3 ODC1 OGDH OTC PAH PAOX PCBD1 PCSK1 PHGDH PNMT POMC PRODH PSAT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PSPH PYCR1 QDPR SAT1 SHMT1 SLC25A10 SLC25A15 SLC25A2 SLC25A21 SLC5A5 SLC6A8 SMOX SMS SQRDL SRM SUOX TAT TDO2 TH TMLHE TPH1 TPH2 TPO TSHB TST UROC1 +REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates AAAS ABCC5 ACAN AGL AGRN ALDOA ALDOB ALDOC AMY1A AMY1B AMY1C AMY2A AMY2B ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 BCAN BGN CALM1 CALM2 CALM3 CD44 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 DCN DSE ENO1 ENO2 ENO3 EXT1 EXT2 FBP1 FBP2 FMOD G6PC G6PC2 G6PC3 G6PD GALE GALK1 GALT GAPDH GAPDHS GBE1 GCK GCKR GLB1 GLCE GNS GOT1 GOT2 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPI GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GYS2 HAS1 HAS2 HAS3 HEXA HEXB HK1 HK2 HK3 HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST1P1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 IDS IDUA KERA KHK LCT LOC642969 LOC644504 LOC644691 LOC648749 LOC650556 LOC652899 LOC729020 LOC730418 LOC730924 LUM LYVE1 MDH1 MDH2 MGAM NAGLU NCAN NDST1 NDST2 NDST3 NDST4 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 OGN OMD PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGLS PGM1 PGM2 PHKA1 PHKA1P1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM2 POM121 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKACA PRKACB PRKACG PRPS1 PRPS1L1 PRPS2 PYGB PYGL PYGM RAE1 RANBP2 RPE RPIA SDC1 SDC2 SDC3 SDC4 SEH1L SGSH SI SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC37A4 SLC5A1 SLC9A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL6 STAB2 TALDO1 TKT TPI1 TPI1P1 TPR TREH UGP2 UST VCAN +REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins A2M ABCA1 ABCB11 ABCB4 ABCC3 ABCD1 ABCD1P5 ABCG1 ABCG5 ABCG8 ABHD5 ACAA1 ACACA ACACB ACADL ACADM ACADS ACADVL ACAT1 ACER1 ACER2 ACER3 ACHE ACLY ACOT8 ACOX1 ACOX2 ACOX3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 AGPS AGT AKR1B1 AKR1C4 AKR1D1 ALAS1 ALB AMACR AMN ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 APOB APOC2 APOC3 APOE ARF1 ARF3 ARNTL ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C BAAT BCMO1 BDH1 BMP1 CAV1 CCNC CD36 CDIPT CDK19 CDK8 CDS1 CDS2 CEPT1 CERK CERS2 CERS3 CERS4 CERS5 CERS6 CETP CGA CH25H CHAT CHKA CHKB CHPT1 CLOCK CLPS COL4A3BP CPT1A CPT1B CPT2 CRAT CREBBP CRLS1 CROT CSNK1G2 CTGF CTSA CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP21A2 CYP24A1 CYP27A1 CYP27B1 CYP2R1 CYP39A1 CYP46A1 CYP4A11 CYP51A1 CYP7A1 CYP7B1 CYP8B1 DECR1 DEGS1 DEGS2 DGAT1 DGAT2 DHCR24 DHCR7 EBP ECHS1 ECI1 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 ENPP7 EP300 EPT1 ESRRA ETNK1 ETNK2 FABP1 FABP4 FABP6 FADS1 FADS2 FAR1 FAR2 FASN FDFT1 FDPS FHL2 FIG4 G0S2 GAL3ST1 GALC GBA GBA2 GBA3 GC GGPS1 GK GLA GLB1 GLIPR1 GM2A GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L GPD2 GRHL1 HACL1 HADH HADHA HADHB HDAC3 HEXA HEXB HMGCL HMGCR HMGCS1 HMGCS2 HSD11B1 HSD17B1 HSD17B12 HSD17B3 HSD17B4 HSD17B7 HSD3B1 HSD3B2 HSD3B7 HSPG2 IDH1 IDI1 IDI2 INPP4B INPP5E INPP5J INPP5K INPPL1 KDSR LBR LCAT LCLAT1 LDLR LDLRAP1 LGMN LHB LIPC LIPE LOC651621 LOC729155 LOC730412 LOC730418 LOC731292 LPA LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 LPL LRAT LRP2 LSS MBOAT1 MBOAT2 MBOAT7 MCEE ME1 MED1 MED10 MED11 MED12 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MGLL MSMO1 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 MTTP MUT MVD MVK NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NEU1 NEU2 NEU3 NEU4 NFYA NFYB NPAS2 NR1D1 NRF1 NSDHL OCRL OSBP OXCT1 P4HB PCCA PCCB PCYT1A PCYT1B PCYT2 PEMT PEX11A PGS1 PHOSPHO1 PHYH PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1B PIP5K1C PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLA2G6 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PLIN1 PLIN2 PLTP PMVK PNLIP PNLIPRP2 PNPLA2 PNPLA3 PNPLA8 POMC PPAP2A PPAP2B PPAP2C PPARA PPARG PPARGC1A PPARGC1B PPM1L PPP1CA PPP1CB PPP1CC PRIC285 PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKD1 PSAP PTDSS1 PTDSS2 PTEN RBP2 RDH11 RORA RXRA SACM1L SAR1B SC5DL SCARB1 SCP2 SDC1 SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SIN3A SIN3B SLC10A1 SLC10A2 SLC25A1 SLC25A17 SLC25A20 SLC27A1 SLC27A2 SLC27A5 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLCO1A2 SLCO1B1 SLCO1B3 SMARCD3 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPTLC1 SPTLC2 SQLE SRD5A1 SRD5A2 SRD5A3 SREBF1 SREBF2 STAR STARD4 STARD5 STARD6 STS SULT2A1 SUMF1 SUMF2 SYNJ1 SYNJ2 TAZ TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TECR TGS1 TIAM2 TM7SF2 TNFRSF21 TPTE2 TRIB3 TXNRD1 UGCG UGT1A9 VAC14 VAPA VAPB WWTR1 YAP1 +REACTOME_METABOLISM_OF_MRNA Genes involved in Metabolism of mRNA AKT1 ANP32A C2orf29 CASC3 CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT7 CNOT8 DCP1A DCP1B DCP2 DCPS DDX6 DIS3 EDC3 EDC4 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 ELAVL1 ETF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM153A FAU GSPT2 HNRNPD HSPA1B HSPA8 HSPB1 KHSRP LOC641895 LOC643446 LOC645139 LOC645947 LOC646184 LOC647074 LOC649602 LOC651789 LOC651825 LOC651894 LOC652607 LOC652826 LOC653881 LOC730343 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 MAGOH MAPK11 MAPK14 MAPKAPK2 NCBP1 NCBP2 NUP214 PABPC1 PAIP1 PARN PATL1 PPP2CA PPP2R1A PPP2R2A PRKCA PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBM8A RNPS1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 RQCD1 SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 TNFSF13 TNKS1BP1 TNPO1 UBA52 UPF2 UPF3A UPF3B XPO1 XRN1 YWHAB YWHAZ ZFP36 ZFP36L1 +REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA AAAS CLNS1A DDX20 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PHAX POM121 PRMT5 RAE1 RANBP2 SEH1L SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SNUPN TGS1 TPR WDR77 +REACTOME_METABOLISM_OF_NUCLEOTIDES Genes involved in Metabolism of nucleotides ADA ADAL ADK ADSL ADSS ADSSL1 AGXT2 AK1 AK2 AK5 AMPD1 AMPD2 AMPD3 APRT ATIC CAD CAT CDA CMPK1 CTPS CTPS2 DCK DCTD DGUOK DHODH DPYD DPYS DTYMK DUT GART GDA GLRX GMPR GMPR2 GMPS GPX1 GSR GUK1 HPRT1 IMPDH1 IMPDH2 NME1 NME1-NME2 NME2 NME4 NT5C NT5C1A NT5C1B NT5C2 NT5C3 NT5E NT5M PAICS PFAS PNP PPAT RRM1 RRM2 RRM2B TK1 TK2 TXN TXNRD1 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 XDH +REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines ADC ADI1 AGMAT AMD1 APIP ENOPH1 GOT1 MRI1 MTAP ODC1 PAOX SAT1 SMOX SMS SRM +REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins ALAD ALAS1 ALAS2 BLVRA BLVRB CPOX FECH HMBS HMOX1 HMOX2 PPOX UGT1A1 UROD UROS +REACTOME_METABOLISM_OF_PROTEINS Genes involved in Metabolism of proteins ACO2 ACTB ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 AP3M1 ARFGEF2 ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ATP5A1 ATP5B ATP5G1 B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 BCS1L C18orf55 C1GALT1 C1GALT1C1 CALR CANX CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CHCHD4 COQ2 COX17 CS CYC1 DAD1 DDOST DHPS DNAJC19 DOHH DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 EEF1A1 EEF1B2 EEF1D EEF1DP1 EEF1G EEF2 EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3FP3 EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5A EIF5A2 EIF5B ETF1 F10 F2 F7 F9 FAM153A FAU FBXL3 FBXL5 FBXO4 FBXO6 FBXW2 FBXW4 FBXW5 FBXW7 FKBP9 FURIN FUT8 FXC1 FXN GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT2 GALNT3 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL1 GALNTL2 GALNTL4 GALNTL5 GALNTL6 GANAB GCNT1 GCNT3 GCNT4 GCNT6 GFER GFPT2 GGCX GMPPA GMPPB GNPNAT1 GPAA1 GRPEL1 GRPEL2 GSPT2 HSCB HSPA9 HSPD1 IDH3G KIF13A KIFC3 LDHD LMAN1 LOC285407 LOC440490 LOC641895 LOC642727 LOC644589 LOC646184 LOC646675 LOC646677 LOC647030 LOC647074 LOC649602 LOC650638 LOC650667 LOC650674 LOC651825 LOC651894 LOC652607 LOC652612 LOC652741 LOC653566 LOC653881 LOC653994 LOC654264 LOC729998 LOC730343 LOC732162 LOC732391 LONP2 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPI MTX1 MTX2 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC21 MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 NOP56 PABPC1 PAM16 PDIA3 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 PGAP1 PGM3 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLAUR PMM1 PMM2 PMPCA PMPCB PREB PRKCSH PROC PROS1 PROZ RFT1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 SAMM50 SAR1B SEC11A SEC11C SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SEMA6D SLC25A12 SLC25A13 SLC25A4 SLC25A6 SPCS1 SPCS2 SPCS3 SPHK1 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRP9P1 SRPR SRPRB SSR1 SSR2 SSR3 SSR4 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST8SIA2 ST8SIA3 ST8SIA6 STS STT3A SUMF1 SUMF2 TAZ TBCA TBCB TBCC TBCD TBCE TCP1 TIMM10 TIMM13 TIMM17A TIMM17B TIMM22 TIMM23B TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TOMM20 TOMM22 TOMM40 TOMM5 TOMM7 TOMM70A TRAM1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUSC3 UBA52 UGGT1 UGGT2 USP11 VBP1 VDAC1 VKORC1 WBSCR17 XRN2 +REACTOME_METABOLISM_OF_RNA Genes involved in Metabolism of RNA AAAS AKT1 ANP32A C2orf29 CASC3 CLNS1A CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT7 CNOT8 DCP1A DCP1B DCP2 DCPS DDX20 DDX6 DIS3 EDC3 EDC4 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 ELAVL1 ETF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM153A FAU GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GSPT2 HNRNPD HSPA1B HSPA8 HSPB1 KHSRP LOC641895 LOC643446 LOC645139 LOC645947 LOC646184 LOC647074 LOC649602 LOC651789 LOC651825 LOC651894 LOC652607 LOC652826 LOC653881 LOC730343 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 MAGOH MAPK11 MAPK14 MAPKAPK2 NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PABPC1 PAIP1 PARN PATL1 PHAX POM121 PPP2CA PPP2R1A PPP2R2A PRKCA PRKCD PRMT5 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAE1 RANBP2 RBM8A RNPS1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 RQCD1 SEH1L SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SNUPN TGS1 TNFSF13 TNKS1BP1 TNPO1 TPR UBA52 UPF2 UPF3A UPF3B WDR77 XPO1 XRN1 YWHAB YWHAZ ZFP36 ZFP36L1 +REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D AKR1B1 BCMO1 CGA CLPS CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 CYP24A1 CYP27B1 CYP2R1 GC HSD11B1 HSD17B1 HSD17B3 HSD3B1 HSD3B2 LGMN LHB LRAT LRP2 PNLIP POMC RBP2 RDH11 SRD5A1 SRD5A2 SRD5A3 STAR STARD4 STARD5 STARD6 +REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors AASDHPPT ACP5 COASY CYB5A CYB5R3 DHFR DHFRP1 ENPP1 FASN FLAD1 FPGS GPHN GSTO1 GSTO2 MOCOS MOCS1 MOCS2 MOCS3 MTHFD1 MTHFR NADK NADSYN1 NAMPT NFS1 NMNAT1 NMNAT2 NMNAT3 PANK1 PANK2 PANK3 PANK4 PDXK PNPO PPCDC PPCS QPRT RFK SHMT1 SLC19A1 SLC19A2 SLC19A3 SLC23A1 SLC23A2 SLC25A16 SLC25A32 SLC2A1 SLC2A3 SLC46A1 SLC5A6 THTPA TPK1 +REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters CP HEPH SLC11A1 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A7 SLC30A8 SLC31A1 SLC39A1 SLC39A10 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC40A1 SLC41A1 SLC41A2 +REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation ACTR1A ACTR1B AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 CANX CD74 CLTA CLTC CTSA CTSB CTSC CTSD CTSF CTSH CTSK CTSL1 CTSL2 CTSO CTSS DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DNM1 DNM2 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 KIF11 KIF15 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2A KIF2B KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIFAP3 KLC1 KLC2 KLC3 KLC4 LGMN OSBPL1A RAB7A RACGAP1 RILP SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SH3GL2 SPTBN2 +REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis DGCR8 DICER1 DROSHA EIF2C1 EIF2C2 EIF2C3 EIF2C4 LOC643631 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RAN TARBP2 XPO5 +REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation ACADL ACADM ACADS ACADVL DECR1 ECHS1 ECI1 HADH HADHA HADHB MCEE MUT PCCA PCCB +REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import ACO2 ATP5A1 ATP5B ATP5G1 BCS1L C18orf55 CHCHD4 COQ2 COX17 CS CYC1 DNAJC19 FXC1 FXN GFER GRPEL1 GRPEL2 HSCB HSPA9 HSPD1 IDH3G LDHD LOC440490 LOC642727 LOC644589 LOC646675 LOC646677 LOC650667 LOC650674 MTX1 MTX2 PAM16 PMPCA PMPCB SAMM50 SLC25A12 SLC25A13 SLC25A4 SLC25A6 TAZ TIMM10 TIMM13 TIMM17A TIMM17B TIMM22 TIMM23B TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TOMM20 TOMM22 TOMM40 TOMM5 TOMM7 TOMM70A VDAC1 +REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation AARS2 CARS2 DARS2 EARS2 FARS2 GARS HARS2 IARS2 KARS LARS2 MARS2 NARS2 PARS2 PPA2 QARS RARS2 SARS2 TARS2 VARS2 WARS2 YARS2 +REACTOME_MITOTIC_G1_G1_S_PHASES Genes involved in Mitotic G1-G1/S phases CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CKS1B CUL1 DBF4 DHFR DHFRP1 DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 FBXO5 HDAC1 LIN37 LIN52 LIN54 LIN9 LOC441488 LOC645084 LOC652826 LOC729964 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYBL2 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 POLA1 POLA2 POLE POLE2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RB1 RBBP4 RBBP4P1 RBL1 RBL2 RPA1 RPA2 RPA3 RPA4 RPS27A RPS27AP11 RRM2 SKP1 SKP2 TFDP1 TK2 TYMS UBA52 WEE1 +REACTOME_MITOTIC_G2_G2_M_PHASES Genes involved in Mitotic G2-G2/M phases ACTR1A AKAP9 ALMS1 AZI1 CCNA1 CCNA2 CCNB1 CCNB2 CCNH CDC25A CDC25B CDC25C CDK1 CDK2 CDK5RAP2 CDK7 CENPJ CEP135 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 E2F1 E2F3 FGFR1OP HAUS2 HSP90AA1 LOC440917 LOC730418 MAPRE1 MNAT1 NEDD1 NEK2 NINL NUMA1 OFD1 PAFAH1B1 PCM1 PCNT PKMYT1 PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBBP2 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 WEE1 XPO1 YWHAE YWHAG +REACTOME_MITOTIC_M_M_G1_PHASES Genes involved in Mitotic M-M/G1 phases AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CCDC99 CDC20 CDC45 CDC6 CDC7 CDCA8 CDK2 CDT1 CENPA CENPC1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CKAP5 CLASP1 CLIP1 DBF4 DSN1 E2F1 E2F2 E2F3 ERCC6L FBXO5 GMNN GORASP1 INCENP ITGB3BP KIF18A KIF20A KIF23 KIF2A KIF2B KIF2C KNTC1 LOC645084 LOC652826 MAD1L1 MAD2L1 MAPRE1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MIS12 MLF1IP NDC80 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP37 NUP43 NUP85 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAFAH1B1 PLK1 PMF1 POLA1 POLA2 POLE POLE2 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RAD21 RANBP2 RANGAP1 RCC2 RPA1 RPA2 RPA3 RPA4 RPS27 RPS27A RPS27AP11 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SKA2L SMC1A SMC3 SPC24 SPC25 STAG1 STAG2 TAOK1 UBA52 XPO1 ZW10 ZWILCH ZWINT +REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CASC5 CCDC99 CDC20 CDCA8 CENPA CENPC1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CKAP5 CLASP1 CLIP1 DSN1 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 MLF1IP NDC80 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP37 NUP43 NUP85 PAFAH1B1 PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAD21 RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEH1L SGOL1 SGOL2 SKA1 SKA2 SKA2L SMC1A SMC3 SPC24 SPC25 STAG1 STAG2 TAOK1 XPO1 ZW10 ZWILCH ZWINT +REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DHX38 LOC643446 MAGOH NCBP1 NCBP2 NFX1 NUDT21 PABPN1 PAPOLA PCF11 RBM8A RNPS1 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 THOC4 U2AF1 U2AF2 UPF3B +REACTOME_MRNA_CAPPING Genes involved in mRNA Capping CCNH CDK7 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT RNMT SUPT5H +REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease DCPS DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 +REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease DCP1A DCP1B DCP2 DDX6 EDC3 EDC4 LOC645947 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 PATL1 XRN1 +REACTOME_MRNA_PROCESSING Genes involved in mRNA Processing A1CF AAAS ADAR ADARB1 APOBEC1 CCAR1 CCNH CD2BP2 CDC40 CDK7 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 EIF4E ERCC2 ERCC3 FUS GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 LOC643446 LOC652147 LOC652857 LOC653889 LSM10 LSM11 LSM2 MAGOH METTL3 MNAT1 NCBP1 NCBP2 NFX1 NHP2L1 NUDT21 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 NXF1 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PRPF4 PRPF6 PRPF8 PTBP1 RAE1 RANBP2 RBM5 RBM8A RBMX RNGTT RNMT RNPS1 SEH1L SF3A1 SF3A2 SF3A3 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SLBP SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 SUPT5H THOC4 TPR TXNL4A U2AF1 U2AF2 UPF3B YBX1 ZNF473 +REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing CCAR1 CD2BP2 CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 FUS GTF2F1 GTF2F2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 LOC643446 LOC652147 LOC653889 LSM2 MAGOH NCBP1 NCBP2 NFX1 NHP2L1 NUDT21 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRPF4 PRPF6 PRPF8 PTBP1 RBM5 RBM8A RBMX RNPS1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 THOC4 TXNL4A U2AF1 U2AF2 UPF3B YBX1 +REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway DDX23 EFTUD2 GTF2F1 GTF2F2 LOC652147 LOC653889 LSM2 NCBP1 NCBP2 NHP2L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PRPF6 PRPF8 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SNRNP200 SNRNP40 SNRPB SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SRSF1 SRSF2 SRSF6 SRSF7 TXNL4A +REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 MLST8 MTOR RHEB RPS6 RPS6KB1 RPTOR +REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction ACTA2 ACTG2 ACTN2 CALD1 CALM1 CALM2 CALM3 DES DMD ITGA1 ITGB5 LMOD1 LOC642076 MYBPC1 MYBPC2 MYH11 MYH3 MYH6 MYH8 MYL1 MYL12B MYL2 MYL3 MYL4 MYL6 MYL6B MYL8P MYL9 MYLK NEB SORBS1 SORBS3 TCAP TLN1 TMOD1 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TPM1 TPM2 TPM3 TPM4 VCL VIM +REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane AGER APP ATF1 ATF2 BTK CDK1 CHUK CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IRAK1 IRAK2 IRAK3 IRAK4 JUN LOC650832 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR TAB1 TAB2 TAB3 TIRAP TLR1 TLR2 TLR4 TLR6 TMEM189-UBE2V1 TRAF6 UBA52 UBE2N +REACTOME_MYOGENESIS Genes involved in Myogenesis ABL1 BNIP2 BOC CDC42 CDH15 CDH2 CDH4 CDON CTNNA1 CTNNB1 MAP2K6 MAPK11 MAPK12 MAPK14 MEF2A MEF2BNB MEF2BNB-MEF2B MEF2C MEF2D MYF5 MYF6 MYOD1 MYOG NEO1 NTN3 TCF12 TCF3 TCF4 +REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 MGAT4A MGAT4B MGAT4C MGAT5 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 FUT8 MAN2A1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle CALR CANX EDEM1 EDEM2 EDEM3 GANAB MAN1B1 MLEC MOGS PDIA3 PRKCSH UGGT1 UGGT2 +REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters SLC18A1 SLC18A2 SLC22A2 SLC6A1 SLC6A11 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions AGRN ARTN CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CNTN2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 GDNF GFRA1 GFRA2 GFRA4 NCAM1 NCAN NRTN PRNP PSPN ST8SIA2 ST8SIA4 +REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth AGRN ARTN CACNA1G CACNA1H CACNA1I CACNA1S CACNB1 CACNB2 CACNB3 CACNB4 CDK1 CNTN2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 CREB1 FGFR1 FYN GDNF GFRA1 GFRA2 GFRA4 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NCAN NRAS NRTN PRNP PSPN PTK2 RAF1 RPS6KA5 SOS1 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC ST8SIA2 ST8SIA4 YWHAB +REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 B2M HLA-A HLA-K PACS1 +REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD28 CD4 CD8B HLA-A HLA-K LCK PACS1 +REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING Genes involved in Negative regulation of FGFR signaling BRAF CBL FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GRB2 KL KLB MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A RPS27A RPS27AP11 SPRY2 SRC UBA52 +REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network AKT1 AKT2 AKT3 LOC729120 LOC731292 PHLPP1 PTEN THEM4 TRIB3 +REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling ATG12 ATG5 CYLD DDX58 HERC5 IFIH1 IKBKE IRF3 ISG15 MAVS NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RNF125 RNF135 RPS27A RPS27AP11 TAX1BP1 TBK1 TNFAIP3 TRAF3 TRIM25 UBA52 UBA7 UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 +REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery AAAS NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 RAE1 RAN RANBP2 SEH1L TPR XPO1 +REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions ACTN1 ACTN2 ACTN4 CD2AP FYN IQGAP1 KIRREL2 KIRREL3 LOC729030 MAGI2 NCK1 NCK2 NPHS1 PIK3CA PIK3CB PIK3R1 PIK3R2 SPTAN1 SPTBN1 WASL +REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling ABLIM1 ABLIM3 CDC42 DCC DOCK1 EZR FYN HFE2 LOC730030 LOC730221 LOC730335 MYO10 NCK1 NEO1 NTN1 NTN4 PITPNA PLCG1 PRKCQ PTK2 RAC1 RGMA RGMB ROBO1 SIAH1 SIAH2 SLIT1 SLIT2 SLIT3 SRC TRIO TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 UNC5A UNC5B UNC5C UNC5D WASL +REACTOME_NEURONAL_SYSTEM Genes involved in Neuronal System ABAT ABCC8 ABCC9 ACHE ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 ALDH2 ALDH5A1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BRAF CACNA1A CACNA1B CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK4 CAMKK1 CHAT CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG COMT CREB1 DLG1 DLG3 DNAJC5 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GAD1 GAD2 GJA10 GJC1 GJD2 GLS GLS2 GLUL GNAI1 GNAI2 GNAI3 GNAL GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP2 HCN1 HCN2 HCN3 HCN4 HRAS HSPA8 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 LOC642105 LOC651907 LOC732445 MAOA MAPK1 MDM2 MYO6 NCALD NEFL NSF PANX1 PANX2 PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PRKACB PRKCA PRKCB PRKCG RAB3A RAF1 RASGRF1 RASGRF2 RIMS1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC22A2 SLC32A1 SLC38A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A3 SNAP25 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 SYN1 SYN2 SYN3 SYT1 SYT2 UNC13B VAMP1 VAMP2 +REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL Genes involved in Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BRAF CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK4 CAMKK1 CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG CREB1 DLG1 DLG3 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GNAI1 GNAI2 GNAI3 GNAL GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP2 HRAS KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 LOC651907 LOC732445 MAPK1 MDM2 MYO6 NCALD NEFL NSF PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PRKACB PRKCA PRKCB PRKCG RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Neurotransmitter Release Cycle ABAT ALDH5A1 CHAT DNAJC5 GAD1 GAD2 GLS GLS2 HSPA8 MAOA RAB3A RIMS1 SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A6 SLC1A7 SLC22A2 SLC32A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 CASP10 CASP8 CHUK DDX58 FADD IFIH1 IKBKB IKBKG MAVS RIPK1 RNF135 TRIM25 +REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire AGER APP ATF1 ATF2 CD14 CDK1 CHUK CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS HMGB1 IKBKB IKBKG IRAK1 IRAK2 JUN LOC650832 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK1 RIPK2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TICAM1 TICAM2 TLR3 TLR4 TRAF6 UBA52 +REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival IKBKB IRAK1 NFKBIA NGF NGFR RELA RPS27A RPS27AP11 SQSTM1 TRAF6 UBA52 +REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADORA2A ADRBK1 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ATF1 BAD BRAF CALM1 CALM2 CALM3 CAMK4 CASP9 CDK1 CDKN1A CDKN1B CHUK CLTA CLTC CREB1 CRK DNAL4 DNM1 DNM2 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOXO1 FOXO3 FOXO4 FRS2 GRB2 GSK3A HRAS IRS1 IRS2 ITPR2 ITPR3 KIDINS220 KRAS LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAP1 MAPKAPK2 MAPKAPK3 MDM2 MEF2A MEF2C MLST8 MTOR NGF NR4A1 NRAS NTRK1 NTRK2 PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RHOA RICTOR RIT1 RIT2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 SH3GL2 SHC1 SHC2 SHC3 SOS1 SRC STAT3 THEM4 TRIB3 TSC2 YWHAB +REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase GUCY1A2 GUCY1A3 GUCY1B3 KCNMB1 KCNMB2 KCNMB3 KCNMB4 MRVI1 NOS1 NOS2 NOS3 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE6A PDE6B PDE6G PDE9A PRKG1 PRKG2 +REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD IKBKB IKBKG IRAK1 IRAK2 MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 NOD1 NOD2 RIPK2 TAB1 TAB2 TAB3 TMEM189-UBE2V1 TNFAIP3 TRAF6 UBE2N +REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex CASC3 EIF4A3 EIF4G1 ETF1 FAM153A FAU GSPT2 LOC641895 LOC643446 LOC646184 LOC647074 LOC649602 LOC651825 LOC651894 LOC652607 LOC653881 LOC730343 MAGOH NCBP1 NCBP2 PABPC1 PPP2CA PPP2R1A PPP2R2A RBM8A RNPS1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 UBA52 UPF2 UPF3A UPF3B +REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle MAOA RAB3A RIMS1 SLC18A2 SLC22A2 SNAP25 STX1A STXBP1 SYT1 VAMP2 +REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription CCNC CDK8 CREBBP CUL1 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A KAT2A KAT2B LOC728030 MAML1 MAML2 MAML3 MAMLD1 MYC NCOR1 NCOR2 RBPJ RBX1 RPS27A RPS27AP11 SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 +REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway CREBBP KAT2A KAT2B LOC728030 MAML1 MAML2 MAML3 MAMLD1 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 +REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK AATF ABR AKAP13 ARHGAP4 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 BAD BCL2L11 ECT2 FGD1 FGD2 FGD3 FGD4 ITSN1 KALRN MAGED1 MAPK8 MCF2 NET1 NGEF NGF NGFR OBSCN PLEKHG2 PREX1 RAC1 RASGRF1 RASGRF2 SOS1 SOS2 TIAM1 TIAM2 TRIO VAV1 VAV3 +REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus APH1A APH1B ITGB3BP MAPK8 NCSTN NGF NGFR PSEN1 PSEN2 PSENEN RPS27A RPS27AP11 SQSTM1 TRAF6 UBA52 +REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation) ATF1 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MAPKAPK2 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 +REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway AR ESR1 ESR2 ESRRA ESRRB ESRRG HNF4A HNF4G LOC728381 LOC731106 MED1 NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1I2 NR1I3 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 PGR PPARA PPARD PPARG RARA RARG RORA RORB RORC RXRA RXRB RXRG THRA THRB VDR +REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4 ADAM17 APH1A APH1B BTC BTRC CSH1 CSN2 CUL1 CXCL12 ERBB4 EREG ESR1 GFAP GH1 GH2 GHR HBEGF JAK2 NCOR1 NCSTN NRG1 NRG2 NRG4 PGR PRL PRLR PSEN1 PSEN2 PSENEN RBX1 S100B SH2B1 SKP1 STAT5A STAT5B TAB2 WWOX YAP1 +REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways AIM2 APP BCL2 BCL2L1 BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD HSP90AB1 IKBKB IKBKG IRAK1 IRAK2 LOC644816 MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 MEFV NLRC4 NLRP1 NLRP3 NOD1 NOD2 P2RX7 PANX1 PSTPIP1 PYCARD RIPK2 TAB1 TAB2 TAB3 TMEM189-UBE2V1 TNFAIP3 TRAF6 TXN TXNIP UBE2N +REACTOME_NUCLEOTIDE_EXCISION_REPAIR Genes involved in Nucleotide Excision Repair CCNH CDK7 DDB1 DDB2 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LIG1 LOC652672 LOC652857 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RAD23B RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 TCEA1 XAB2 XPA XPC +REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors ADORA1 ADORA2A ADORA2B ADORA3 GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 +REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT5 C1GALT1 C1GALT1C1 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT2 GALNT3 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL1 GALNTL2 GALNTL4 GALNTL5 GALNTL6 GCNT1 GCNT3 GCNT4 GCNT6 LOC652741 LOC732162 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC21 MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 WBSCR17 +REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway GNAL GNB1 GNGT1 LOC652692 LOC730421 LOC730808 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AD1 OR10AG1 OR10C1 OR10G2 OR10G3 OR10G4 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J5 OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR14A16 OR14C36 OR14J1 OR14K1 OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1F1 OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A42 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AK2 OR2B11 OR2B2 OR2B3 OR2B6 OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2V2 OR2W1 OR2W3 OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A5 OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C6 OR4D1 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E2 OR4F15 OR4F16 OR4F17 OR4F29 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N3P OR4N4 OR4N5 OR4P4 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F2 OR51G1 OR51G2 OR51I1 OR51I2 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A5 OR52B4 OR52B6 OR52D1 OR52E2 OR52E4 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52R1 OR52W1 OR56A1 OR56A3 OR56A4 OR56B1 OR56B4 OR5A1 OR5A2 OR5AC2 OR5AK2 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5L1 OR5L2 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6F1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 +REACTOME_OPIOID_SIGNALLING Genes involved in Opioid Signalling ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CALM2 CALM3 CAMK4 CDK5 CREB1 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR2 ITPR3 LOC730418 MAPK1 OPRM1 PDE1A PDE1B PDE4B PDE4C PDE4D PDYN PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 POMC PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +REACTOME_OPSINS Genes involved in Opsins OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN4 OPN5 RGR RHO RRH +REACTOME_ORC1_REMOVAL_FROM_CHROMATIN Genes involved in Orc1 removal from chromatin CCNA1 CCNA2 CDC6 CDK2 CDKN1A CDKN1B CDT1 LOC652826 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RB1 RPS27A RPS27AP11 UBA52 +REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 +REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions ITGA1 ITGB1 PLXNA1 PLXNA2 PLXNB3 PLXNC1 PLXND1 SEMA3E SEMA4A SEMA5A SEMA6A SEMA6D SEMA7A TREM2 TYROBP +REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha CUL2 EGLN1 EGLN2 EGLN3 EPAS1 HIF1A HIF3A RBX1 RPS27A RPS27AP11 TCEB1 TCEB1P3 TCEB2 UBA52 UBE2D1 UBE2D2 UBE2D3 VHL +REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins APBB1IP BCAR1 CRK FGA FGB FGG FN1 ITGA2B ITGB3 PTK2 RAP1A RAP1B SRC TLN1 VWF +REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 +REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events HRAS KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 NRAS RALA RALB RALGDS SRC +REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response ATM CCNE1 CCNE2 CDK2 CDKN1A CDKN1B LOC651610 LOC652826 MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RFWD2 RFWD2P1 RPS27A RPS27AP11 TP53 UBA52 +REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint ATM CDC25A CHEK1 CHEK2 LOC651610 LOC652826 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 +REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling AATF ABR ADAM17 AKAP13 APH1A APH1B ARHGAP4 ARHGDIA ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 BAD BCL2L11 CASP2 CASP3 ECT2 FGD1 FGD2 FGD3 FGD4 HDAC1 HDAC2 HDAC3 IKBKB IRAK1 ITGB3BP ITSN1 KALRN LINGO1 LOC440917 MAG MAGED1 MAPK8 MCF2 MYD88 NCSTN NET1 NFKBIA NGEF NGF NGFR NGFRAP1 OBSCN OMG PLEKHG2 PRDM4 PREX1 PRKCI PSEN1 PSEN2 PSENEN RAC1 RASGRF1 RASGRF2 RELA RHOA RIPK2 RPS27A RPS27AP11 RTN4 SMPD2 SORCS3 SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 VAV1 VAV3 YWHAE +REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES Genes involved in p75NTR recruits signalling complexes IKBKB IRAK1 MYD88 NGF NGFR PRKCI RIPK2 RPS27A RPS27AP11 SQSTM1 TRAF6 UBA52 +REACTOME_P75NTR_SIGNALS_VIA_NFKB Genes involved in p75NTR signals via NF-kB IKBKB IRAK1 MYD88 NFKBIA NGF NGFR PRKCI RELA RIPK2 RPS27A RPS27AP11 SQSTM1 TRAF6 UBA52 +REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends ACD H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 POT1 TERF1 TERF2 TERF2IP TINF2 +REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins AQP1 AQP10 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 MIP +REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling CD247 CD274 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 LCK PDCD1 PDCD1LG2 PTPN6 +REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions FYN ITGAV ITGB3 LCK LYN PECAM1 PLCG1 PTPN6 SRC YES1 +REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation EEF1A1 EEF2 FAM153A FAU LOC641895 LOC646184 LOC647074 LOC649602 LOC651825 LOC651894 LOC653881 LOC730343 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 UBA52 +REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis CGA CGB CGB5 CGB8 FSHB INHA INHBA INHBB INHBC INHBE LHB PCSK1 POMC TSHB +REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors AGT AGTR1 AGTR2 ANXA1 APLNR APP AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CCBP2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL1P1 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 DARC EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FPR1 FPR2 FPR3 GAL GALR1 GALR2 GALR3 GAST GHRL GHSR GPER GPR77 GRP GRPR HCRT HCRTR1 HCRTR2 HEBP1 IL8 INSL3 INSL5 KISS1 KISS1R KNG1 LOC652222 LOC653879 LOC728830 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY5R NTS NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 OXT OXTR PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PPYR1 PRLH PRLHR PROK1 PROKR1 PROKR2 PYY QRFP QRFPR RLN2 RLN3 RXFP1 RXFP2 RXFP3 RXFP4 SAA1 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAC1 TAC3 TACR1 TACR2 TACR3 TRH TRHR UTS2 UTS2D UTS2R XCL1 XCL2 XCR1 +REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression ASNS ATF3 ATF4 ATF4P3 ATF6 CCL2 DCP2 DDIT3 DIS3 EIF2AK3 EIF2S1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 HSPA5 IGFBP1 IL8 KHSRP LOC730136 NFYA NFYB PARN +REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism ABCD1 ABCD1P5 ACAA1 ACOT8 ACOX1 ACOX2 ACOX3 AGPS AMACR CRAT CROT FAR1 FAR2 GNPAT HACL1 HSD17B4 IDH1 PHYH SCP2 SLC25A17 SLC27A2 +REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F3 CYP4F8 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FMO1 FMO2 FMO3 LOC731992 MAOA MAOB PAOX POMC PTGIS PTGS1 PTGS2 SMOX TBXAS1 +REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation ACSM1 ACSM2B AHCY BPNT1 CNDP2 COMT CYP1A2 GCLC GCLM GGCT GGT1 GGT5 GGT7 GLYAT GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 LOC648338 MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR NAT1 NAT2 NNMT OPLAH PAPSS1 PAPSS2 SLC35D1 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TPMT UGDH UGP2 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B10 UGT2B11 UGT2B17 UGT2B28 UGT2B4 UGT2B7 +REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE Genes involved in Phospholipase C-mediated cascade ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CALM2 CALM3 CAMK4 CREB1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 ITPR2 ITPR3 KL KLB LOC730418 PDE1A PDE1B PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG +REACTOME_PHOSPHOLIPID_METABOLISM Genes involved in Phospholipid metabolism ACER1 ACER2 ACER3 ACHE AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 ARF1 ARF3 ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C CDIPT CDS1 CDS2 CEPT1 CERK CERS2 CERS3 CERS4 CERS5 CERS6 CHAT CHKA CHKB CHPT1 COL4A3BP CRLS1 CSNK1G2 CTSA DEGS1 DEGS2 DGAT1 DGAT2 ENPP7 EPT1 ETNK1 ETNK2 FIG4 GAL3ST1 GALC GBA GBA2 GBA3 GLA GLB1 GM2A GNPAT GPAM GPAT2 GPCPD1 GPD1 GPD1L HADHA HADHB HEXA HEXB INPP4B INPP5E INPP5J INPP5K INPPL1 KDSR LCLAT1 LOC729155 LOC731292 LPCAT1 LPCAT2 LPCAT3 LPCAT4 LPGAT1 LPIN1 LPIN2 LPIN3 MBOAT1 MBOAT2 MBOAT7 MGLL MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 NEU1 NEU2 NEU3 NEU4 OCRL OSBP PCYT1A PCYT1B PCYT2 PEMT PGS1 PHOSPHO1 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1B PIP5K1C PITPNB PLA2G10 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4F PLA2G5 PLA2G6 PLBD1 PLD1 PLD2 PLD3 PLD4 PLD6 PNPLA2 PNPLA3 PNPLA8 PPAP2A PPAP2B PPAP2C PPM1L PRKD1 PSAP PTDSS1 PTDSS2 PTEN SACM1L SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPTLC1 SPTLC2 STS SUMF1 SUMF2 SYNJ1 SYNJ2 TAZ TPTE2 UGCG VAC14 VAPA VAPB +REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains CD247 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 LCK PAG1 PTPRC +REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC23 CDC26 CDC26P1 CDC27 CDK1 LOC647654 LOC649620 LOC650621 LOC651763 LOC730594 PLK1 UBE2C UBE2D1 UBE2E1 +REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 FOXO1 FOXO3 FOXO4 GSK3A IRS1 IRS2 LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NGF NR4A1 NTRK1 PDPK1 PHLPP1 PIK3CA PIK3CB PIK3R1 PIK3R2 PTEN RHOA RICTOR RPS6KB2 THEM4 TRIB3 TSC2 +REACTOME_PI3K_CASCADE Genes involved in PI3K Cascade AKT2 CAB39 CAB39L DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 INS INSR IRS1 IRS2 KL KLB LOC644462 LOC729120 LOC730244 MLST8 MTOR PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPS6 RPS6KB1 RPTOR STK11 STRADA STRADB THEM4 TLR9 TRIB3 TSC1 TSC2 +REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING Genes involved in PI3K events in ERBB2 signaling AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CDKN1A CDKN1B CHUK CREB1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FOXO1 FOXO3 FOXO4 GAB1 GRB2 GSK3A HBEGF LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NR4A1 NRG1 NRG2 NRG4 PDPK1 PHLPP1 PIK3CA PIK3R1 PTEN RICTOR RPS6KB2 THEM4 TRIB3 TSC2 +REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Genes involved in PI3K events in ERBB4 signaling AKT1 AKT1S1 AKT2 AKT3 BAD BTC CASP9 CDKN1A CDKN1B CHUK CREB1 ERBB4 EREG FOXO1 FOXO3 FOXO4 GSK3A HBEGF LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NR4A1 NRG1 NRG2 NRG4 PDPK1 PHLPP1 PIK3CA PIK3R1 PTEN RICTOR RPS6KB2 THEM4 TRIB3 TSC2 +REACTOME_PI_3K_CASCADE Genes involved in PI-3K cascade AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 GAB1 GRB2 GSK3A KL KLB LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NR4A1 PDPK1 PHLPP1 PIK3CA PIK3R1 PTEN RICTOR RPS6KB2 THEM4 TRIB3 TSC2 +REACTOME_PI_METABOLISM Genes involved in PI Metabolism ARF1 ARF3 FIG4 INPP4B INPP5E INPP5J INPP5K INPPL1 LOC731292 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP5K1B PIP5K1C PITPNB PTEN SACM1L SYNJ1 SYNJ2 TPTE2 VAC14 +REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 FOXO1 FOXO3 FOXO4 GSK3A LOC729120 LOC731292 MAPKAP1 MDM2 MLST8 MTOR NR4A1 PDPK1 PHLPP1 PTEN RICTOR RPS6KB2 THEM4 TRIB3 TSC2 +REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CREB1 LOC730418 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B +REACTOME_PKB_MEDIATED_EVENTS Genes involved in PKB-mediated events AKT2 CAB39 CAB39L EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 LOC644462 MLST8 MTOR PDE3B PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPS6 RPS6KB1 RPTOR STK11 STRADA STRADB TSC1 TSC2 +REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION Genes involved in Platelet activation, signaling and aggregation A2M ABCC4 ACTN1 ACTN2 ACTN4 ADRA2A ADRA2B AKT1 AKT2 AKT3 ALB ALDOA APBB1IP APOA1 APP ARRB1 ARRB2 BCAR1 BRPF3 CALM1 CALM2 CALM3 CALU CAP1 CD36 CD63 CD9 CDC42 CFD CFL1 CLU COL1A1 COL1A2 CRK CSK DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ EGF F13A1 F2 F2R F2RL2 F2RL3 F5 F8 FCER1G FGA FGB FGG FIGF FN1 FYN GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GP1BA GP1BB GP5 GP9 GRB2 HABP4 HGF HRG HSPA5 ITGA2B ITGB3 ITPR2 ITPR3 KNG1 LAMP2 LAT LCK LCP2 LEFTY2 LOC128192 LOC131691 LOC643997 LOC652612 LOC654188 LOC727848 LOC730221 LOC730335 LYN MAPK1 MAPK14 MAPK3 MGLL MMRN1 MPL P2RY1 P2RY12 PDGFA PDGFB PDPK1 PECAM1 PF4 PFN1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCG2 PLEK PLG POTEM PPBP PPIA PPIAP22 PPIAP8 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ PROS1 PSAP PTK2 PTPN1 RAC1 RAC2 RAF1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 RHOA RHOB RHOG SCG3 SELP SERPINA1 SERPINE1 SERPINF2 SERPING1 SHC1 SOD1 SOS1 SPARC SRC SRGN STX4 STXBP3 SYK TBXA2R TF TGFB1 TGFB2 TGFB3 THBS1 THPO TIMP1 TLN1 TMSB4X TRPC3 TRPC6 TRPC7 TUBA4A VAV1 VAV3 VCL VEGFA VEGFB VEGFC VWF WDR1 YWHAZ +REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen COL1A1 COL1A2 FCER1G FYN GP1BA GP1BB GP5 GP9 ITGA2 ITGB1 LYN VWF +REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION Genes involved in Platelet Aggregation (Plug Formation) ADRA2A ADRA2B AKT1 APBB1IP BCAR1 CRK CSK F2 FGA FGB FGG FN1 GP1BA GP1BB GP5 GP9 GRB2 ITGA2B ITGB3 MPL PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK THPO TLN1 VWF +REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 ITPR2 ITPR3 LOC730221 LOC730335 ORAI1 P2RX1 SLC8A1 SLC8A2 SLC8A3 STIM1 TRPC3 TRPC6 TRPC7 +REACTOME_PLATELET_HOMEOSTASIS Genes involved in Platelet homeostasis APOB ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 FGR GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GUCY1A2 GUCY1A3 GUCY1B3 ITPR2 ITPR3 KCNMB1 KCNMB2 KCNMB3 KCNMB4 LOC730221 LOC730335 LRP8 MAPK14 MRVI1 NOS1 NOS2 NOS3 ORAI1 P2RX1 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE5A PDE6A PDE6B PDE6G PDE9A PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKG1 PRKG2 PTGIR PTPN6 SLC8A1 SLC8A2 SLC8A3 STIM1 TRPC3 TRPC6 TRPC7 +REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL APOB FGR LRP8 MAPK14 PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN6 +REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 CALM1 CALM2 CALM3 CAMK4 CREB1 GNAI1 GNAI2 GNAI3 GNAO1 GNAT1 GNAT2 GNAZ ITPR2 ITPR3 LOC730418 MAPK1 PDE1A PDE1B PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG +REACTOME_POL_SWITCHING Genes involved in Polymerase switching PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC2 RFC3 RFC4 RFC5 +REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway LOC654264 TBCA TBCB TBCC TBCD TBCE TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 +REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events ACTN2 ADCY1 ADCY3 ADCY8 AKAP9 BRAF CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK4 CAMKK1 CREB1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS MAPK1 NEFL PDPK1 PRKACB RAF1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS +REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins DPM1 DPM2 DPM3 GPAA1 PGAP1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLAUR SEMA6D +REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION Genes involved in Post-translational protein modification ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 B3GNT9 B3GNTL1 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 C1GALT1 C1GALT1C1 CALR CANX DAD1 DDOST DHPS DOHH DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 EDEM1 EDEM2 EDEM3 EIF5A EIF5A2 F10 F2 F7 F9 FURIN FUT8 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT2 GALNT3 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNTL1 GALNTL2 GALNTL4 GALNTL5 GALNTL6 GANAB GCNT1 GCNT3 GCNT4 GCNT6 GFPT2 GGCX GMPPA GMPPB GNPNAT1 GPAA1 LMAN1 LOC285407 LOC652612 LOC652741 LOC732162 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 MLEC MOGS MPI MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC21 MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 PDIA3 PGAP1 PGM3 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PLAUR PMM1 PMM2 PREB PRKCSH PROC PROS1 PROZ RFT1 RPN1 RPN2 SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A SEMA6D ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST8SIA2 ST8SIA3 ST8SIA6 STS STT3A SUMF1 SUMF2 TUSC3 UGGT1 UGGT2 VKORC1 WBSCR17 +REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels ABCC8 ABCC9 GABBR1 GABBR2 GNB1 GNB2 GNB3 GNG10 GNG12 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HCN1 HCN2 HCN3 HCN4 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 +REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression ABCA1 ABCB4 ACADM ACOX1 ACSL1 AGT ALAS1 ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARNTL CCNC CD36 CDK19 CDK8 CLOCK CPT1A CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 EP300 ESRRA FABP1 FADS1 FDFT1 FHL2 G0S2 GLIPR1 GRHL1 HDAC3 HMGCR HMGCS1 HMGCS2 ME1 MED1 MED10 MED11 MED12 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NFYA NFYB NPAS2 NR1D1 NRF1 PEX11A PLIN2 PPARA PPARG PPARGC1A PPARGC1B PRIC285 RORA RXRA SLC27A1 SMARCD3 SREBF1 SREBF2 SULT2A1 TBL1X TBL1XR1 TEAD1 TEAD2 TEAD3 TEAD4 TGS1 TIAM2 TNFRSF21 TRIB3 TXNRD1 UGT1A9 WWTR1 YAP1 +REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Genes involved in Pre-NOTCH Expression and Processing ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCND1 CREBBP E2F1 E2F3 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EP300 FURIN JUN KAT2A KAT2B LFNG LOC441488 LOC728030 MAML1 MAML2 MAML3 MAMLD1 MFNG MOV10 NOTCH2 NOTCH3 NOTCH4 POFUT1 POGLUT1 RAB6A RBPJ RFNG SEL1L SNW1 ST3GAL3 ST3GAL6 TFDP1 TMED2 TNRC6A TNRC6B TNRC6C TP53 +REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi ATP2A1 ATP2A2 ATP2A3 B4GALT1 FURIN LFNG MFNG NOTCH2 NOTCH3 NOTCH4 RAB6A RFNG SEL1L ST3GAL3 ST3GAL6 TMED2 +REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation CCND1 CREBBP E2F1 E2F3 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EP300 JUN KAT2A KAT2B LOC441488 LOC728030 MAML1 MAML2 MAML3 MAMLD1 MOV10 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 TFDP1 TNRC6A TNRC6B TNRC6C TP53 +REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 LOC654264 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 +REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG +REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA AAAS CCAR1 CD2BP2 CDC40 CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 DDX23 DHX38 DHX9 DNAJC8 EFTUD2 EIF4E FUS GTF2F1 GTF2F2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 LOC643446 LOC652147 LOC653889 LSM2 MAGOH METTL3 NCBP1 NCBP2 NFX1 NHP2L1 NUDT21 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 NXF1 PABPN1 PAPOLA PCBP1 PCBP2 PCF11 PHF5A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PRPF4 PRPF6 PRPF8 PTBP1 RAE1 RANBP2 RBM5 RBM8A RBMX RNPS1 SEH1L SF3A1 SF3A2 SF3A3 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SLBP SMC1A SNRNP200 SNRNP40 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD2P1 SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SUGP1 THOC4 TPR TXNL4A U2AF1 U2AF2 UPF3B YBX1 +REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 LSM10 LSM11 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs CLP1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 +REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RPA1 RPA2 RPA3 +REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling BTRC CSH1 CUL1 GH1 GH2 GHR JAK2 PRL PRLR RBX1 SH2B1 SKP1 STAT5A STAT5B +REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events BRAF CDK1 CRK FRS2 HRAS KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 PLCG1 RAF1 RAP1A RAPGEF1 YWHAB +REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PTGIR +REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors GPR44 LOC730002 PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR TBXA2R +REACTOME_PROTEIN_FOLDING Genes involved in Protein folding ACTB AP3M1 ARFGEF2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 FBXL3 FBXL5 FBXO4 FBXO6 FBXW2 FBXW4 FBXW5 FBXW7 FKBP9 KIF13A KIFC3 LOC654264 LOC732391 LONP2 NOP56 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 SPHK1 TBCA TBCB TBCC TBCD TBCE TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 USP11 VBP1 XRN2 +REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins LOC642105 SNAP25 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 VAMP1 VAMP2 +REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK DHPS DOHH EIF5A EIF5A2 F10 F2 F7 F9 FURIN GGCX LOC652612 PROC PROS1 PROZ STS SUMF1 SUMF2 VKORC1 +REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism CAT GDA GPX1 NT5C NT5C1A NT5C1B NT5C2 NT5E PNP XDH +REACTOME_PURINE_METABOLISM Genes involved in Purine metabolism ADA ADAL ADK ADSL ADSS ADSSL1 AMPD1 AMPD2 AMPD3 APRT ATIC CAT DCK DGUOK GART GDA GMPR GMPR2 GMPS GPX1 HPRT1 IMPDH1 IMPDH2 NT5C NT5C1A NT5C1B NT5C2 NT5E PAICS PFAS PNP PPAT XDH +REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis ADSL ADSS ADSSL1 ATIC GART GMPS IMPDH1 IMPDH2 PAICS PFAS PPAT +REACTOME_PURINE_SALVAGE Genes involved in Purine salvage ADA ADAL ADK AMPD1 AMPD2 AMPD3 APRT DCK DGUOK GMPR GMPR2 HPRT1 PNP +REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism AGXT2 DPYD DPYS NT5C NT5C1A NT5C3 NT5E NT5M TYMP UPB1 UPP1 UPP2 +REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism AGXT2 CAD CDA DCK DCTD DHODH DPYD DPYS DUT NT5C NT5C1A NT5C3 NT5E NT5M TK1 TK2 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 +REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism BSG DLAT DLD LDHA LDHB LOC650883 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR SLC16A1 SLC16A3 SLC16A8 +REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle ACO2 ADHFE1 BSG CS D2HGDH DLAT DLD DLST FH IDH1 IDH2 IDH3A IDH3B IDH3G L2HGDH LDHA LDHB LOC283398 LOC646675 LOC646677 LOC650667 LOC650674 LOC650883 LOC651820 MDH2 NNT OGDH PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR SDHA SDHB SDHC SDHD SLC16A1 SLC16A3 SLC16A8 SUCLA2 SUCLA2P1 SUCLG1 SUCLG2 +REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade CDK1 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 YWHAB +REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling LOC730418 PRKACA PRKACB PRKACG PRKG1 RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SIPA1 YWHAB YWHAZ +REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor ACTN2 AKAP9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS NEFL RASGRF1 RASGRF2 +REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 NOTCH2 NOTCH3 NOTCH4 RPS27A RPS27AP11 UBA52 +REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes ACTR1A AKAP9 ALMS1 AZI1 CCNB1 CDK1 CDK5RAP2 CENPJ CEP135 CEP164 CEP192 CEP250 CEP290 CEP41 CEP57 CEP63 CEP70 CEP72 CEP76 CETN2 CKAP5 CLASP1 CNTRL CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FGFR1OP HAUS2 HSP90AA1 LOC440917 LOC730418 MAPRE1 NEDD1 NEK2 NINL NUMA1 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBBP2 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 YWHAE YWHAG +REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes CCNB1 CDK1 NEDD1 NUMA1 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 +REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts ABCB11 ABCC3 ALB BAAT FABP6 SLC10A1 SLC10A2 SLC27A5 SLCO1A2 SLCO1B1 SLCO1B3 +REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTC DNM1 DNM2 DPYSL2 EZR KIAA1598 KIF4A KIF4B L1CAM MAPK1 MSN NUMB RDX RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SH3GL2 SRC +REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR ADAM17 APH1A APH1B NCSTN NGFR PSEN1 PSEN2 PSENEN RELA TRAF6 +REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1 CAB39 CAB39L LOC644462 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 STRADA STRADB +REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis APPL1 ARHGAP10 CASP3 CASP9 DAPK1 DAPK2 DAPK3 DCC LOC652826 MAGED1 PAK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 UBA52 UNC5A UNC5B +REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development AKT1 AKT2 AKT3 FGF10 FOXA2 FOXA3 FOXO1 GCK HES1 HNF1A HNF1B HNF4A HNF4G IAPP INS INSM1 MAFA NEUROD1 NEUROG3 NKX2-2 NKX6-1 NR5A2 ONECUT1 ONECUT3 PAX6 PDX1 PKLR PTF1A RBPJ SLC2A2 +REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade C2 C3 C4A C4BPA C4BPB CD46 CD55 CFB CFH CFHR3 CFI CR1 LOC653879 PROS1 +REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells AKT1 AKT2 AKT3 FOXA2 FOXA3 FOXO1 GCK HNF1A HNF4A HNF4G IAPP INS MAFA NEUROD1 NKX2-2 NKX6-1 PAX6 PDX1 PKLR SLC2A2 +REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein AAAS GCK GCKR NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L TPR +REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen ARNT CA9 CREBBP CUL2 EGLN1 EGLN2 EGLN3 EP300 EPAS1 EPO HIF1A HIF1AN HIF3A RBX1 RPS27A RPS27AP11 TCEB1 TCEB1P3 TCEB2 UBA52 UBE2D1 UBE2D2 UBE2D3 VEGFA VHL +REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 JAK1 PTPN1 PTPN6 SOCS1 SOCS3 STAT1 STAT2 TYK2 USP18 +REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling IFNG IFNGR1 IFNGR2 JAK1 JAK2 LOC646981 PIAS1 PTPN1 PTPN2 PTPN6 SOCS1 SOCS3 STAT1 SUMO1 +REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) CTSG F2 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 KLK3 MMP1 MMP2 PAPPA PAPPA2 PLG +REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion ABCC8 ADCY5 ADCY6 ADCY8 ADRA2A AKAP5 CACNA1A CACNB2 CACNB3 CDX2 CHRM3 CTNNB1 DPP4 FFAR1 GATA4 GCG GIP GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAO1 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPR119 GRP INS IQGAP1 ISL1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 LEP LOC653566 LOC730413 LOC730418 MARCKS O3FAR1 PAX6 PCSK1 PLCB1 PLCB2 PLCB3 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAP1B RAPGEF3 RAPGEF4 SEC11A SEC11C SLC25A4 SLC25A5 SLC25A6 SLC2A1 SLC2A2 SNAP25 SPCS1 SPCS2 SPCS3 STX1A STXBP1 SYT5 VAMP2 +REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine CHRM3 GNA11 GNA14 GNA15 GNAQ LOC730413 MARCKS PLCB1 PLCB2 PLCB3 PRKCA +REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 ADCY5 ADCY6 ADCY8 AKAP5 GCG GLP1R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IQGAP1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNS3 LOC730418 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAP1A RAP1B RAPGEF3 RAPGEF4 +REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling CBL FYN GRB2 KIT KITLG LCK LOC653882 LYN PRKCA PTPN6 SH2B2 SH2B3 SOCS1 SOCS6 SOS1 SRC YES1 +REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE Genes involved in Regulation of mitotic cell cycle ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC14A CDC16 CDC20 CDC23 CDC26 CDC26P1 CDC27 CDK1 CDK2 CUL1 FBXO5 LOC647654 LOC649620 LOC650621 LOC651763 LOC652826 LOC730594 MAD2L1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTTG1 RPS27A RPS27AP11 SKP1 SKP2 UBA52 UBE2C UBE2D1 UBE2E1 +REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements AKT1 ANP32A DCP1A DCP2 DIS3 EIF4G1 ELAVL1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HNRNPD HSPA1B HSPA8 HSPB1 KHSRP LOC652607 LOC652826 MAPK11 MAPK14 MAPKAPK2 NUP214 PABPC1 PARN PRKCA PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 TNFSF13 TNPO1 UBA52 XPO1 XRN1 YWHAB YWHAZ ZFP36 ZFP36L1 +REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC) AZIN1 LOC652826 NQO1 OAZ1 OAZ2 OAZ3 ODC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 +REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex DLAT DLD LOC650883 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR +REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB TSC1 TSC2 +REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL BLNK CBL CRK CRKL FYN GRB2 HCK LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAPGEF1 SYK VAV1 YES1 +REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway ATM ATR FANCD2 LOC648152 LOC651610 LOC651921 RPS27A RPS27AP11 UBA52 USP1 ZBTB32 +REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP2 AQP3 AQP4 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 LOC730418 MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 +REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways DGCR8 DICER1 DROSHA EIF2C1 EIF2C2 EIF2C3 EIF2C4 LOC643631 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RAN TARBP2 TNRC6A TNRC6B TNRC6C XPO5 +REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand DNA2 FEN1 PCNA POLD1 POLD2 POLD3 POLD4 RPA1 RPA2 RPA3 +REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 +REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway APEX1 CCNO FEN1 LIG1 MBD4 MPG MUTYH NTHL1 OGG1 PCNA POLB POLD1 POLD2 POLD3 POLD4 SMUG1 TDG +REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway APEX1 CCNO LIG3 MBD4 MPG MUTYH NTHL1 OGG1 POLB SMUG1 TDG XRCC1 +REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport COX1 COX2 COX3 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CYC1 CYCS CYTB ETFA ETFB ETFDH LOC651820 LOC727947 MTND5P10 ND1 ND2 ND3 ND4 ND4L ND5 ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 SDHA SDHB SDHC SDHD UQCR11 UQCRB UQCRBP1 UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6 ATP8 COX1 COX2 COX3 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CYC1 CYCS CYTB ETFA ETFB ETFDH LOC642727 LOC651820 LOC727947 MTND5P10 ND1 ND2 ND3 ND4 ND4L ND5 ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 SDHA SDHB SDHC SDHD UCP1 UCP2 UCP3 UQCR11 UQCRB UQCRBP1 UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+ A2M ABCC4 ACTN1 ACTN2 ACTN4 ALB ALDOA APOA1 APP BRPF3 CALM1 CALM2 CALM3 CALU CAP1 CD36 CD63 CD9 CFD CFL1 CLU EGF F13A1 F5 F8 FGA FGB FGG FIGF FN1 HABP4 HGF HRG HSPA5 ITGA2B ITGB3 KNG1 LAMP2 LEFTY2 LOC128192 LOC131691 LOC643997 LOC652612 LOC654188 LOC727848 MMRN1 PDGFA PDGFB PECAM1 PF4 PFN1 PLEK PLG POTEM PPBP PPIA PPIAP22 PPIAP8 PRKCA PRKCB PRKCG PROS1 PSAP SCG3 SELP SERPINA1 SERPINE1 SERPINF2 SERPING1 SOD1 SPARC SRGN STX4 STXBP3 TF TGFB1 TGFB2 TGFB3 THBS1 TIMP1 TLN1 TMSB4X TUBA4A VCL VEGFA VEGFB VEGFC VWF WDR1 +REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTC DNAL4 DNM1 DNM2 NGF NTRK1 SH3GL2 +REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide CA1 CA12 CA13 CA14 CA2 CA3 CA4 CA5A CA5B CA6 CA7 CA9 +REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways AGER APP ATG12 ATG5 CASP10 CASP8 CHUK CREBBP CYLD DAK DDX58 DHX58 EP300 FADD HERC5 HMGB1 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IRF1 IRF2 IRF3 IRF7 ISG15 MAP3K1 MAVS NFKB2 NFKBIA NFKBIB NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RELA RIPK1 RNF125 RNF135 RPS27A RPS27AP11 S100A12 S100B SAA1 SIKE1 TANK TAX1BP1 TBK1 TNFAIP3 TRAF2 TRAF3 TRAF6 TRIM25 UBA52 UBA7 UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 +REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI AGER APP CHUK HMGB1 IKBKB IKBKG NFKB2 NFKBIA NFKBIB RELA RIPK1 RIPK3 S100A12 S100B SAA1 TICAM1 TLR3 ZBP1 +REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 LOC731820 MAPK3 MBD2 UBTF +REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription BRF1 BRF2 CBX3 CCNH CDK7 EHMT2 ERCC2 ERCC3 ERCC6 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 KAT2B LOC652857 LOC653972 LOC731820 LZTS1 MAPK3 MBD2 MNAT1 MTERF NFIB POLR1A POLR1B POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K POLRMT POU2F1 PTRF RRN3 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TAF1A TAF1B TAF1C TBP TFAM TFB2M UBTF ZNF143 +REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription CBX3 CCNH CDK7 EHMT2 ERCC2 ERCC3 ERCC6 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 KAT2B LOC652857 LOC653972 LOC731820 MAPK3 MBD2 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR2H POLR2K PTRF RRN3 TAF1A TAF1B TAF1C UBTF +REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation CCNH CDK7 EHMT2 ERCC2 ERCC3 ERCC6 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 KAT2B LOC652857 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR2H POLR2K RRN3 TAF1A TAF1B TAF1C UBTF +REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination CCNH CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR2H POLR2K PTRF TAF1A TAF1B TAF1C UBTF +REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events CCNH CCNT1 CCNT2 CDK7 CDK9 COBRA1 CTDP1 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RDBP SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L WHSC2 +REACTOME_RNA_POL_II_TRANSCRIPTION Genes involved in RNA Polymerase II Transcription CCNH CCNT1 CCNT2 CDC40 CDK7 CDK9 CLP1 COBRA1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTDP1 DHX38 ELL ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC643446 LOC652857 LSM10 LSM11 MAGOH MNAT1 NCBP1 NCBP2 NFX1 NUDT21 PABPN1 PAPOLA PCF11 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBM8A RDBP RNGTT RNMT RNPS1 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TH1L THOC4 U2AF1 U2AF2 UPF3B WHSC2 ZNF473 +REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LOC652857 MNAT1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L TAF1 TAF10 TAF11 TAF12 TAF13 TAF4 TAF4B TAF5 TAF6 TAF9 TBP +REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation LZTS1 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K +REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription BRF1 BRF2 GTF3C2 GTF3C3 GTF3C4 GTF3C5 LZTS1 NFIB POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TBP ZNF143 +REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter BRF1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 LZTS1 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K TBP +REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter BRF2 LZTS1 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 TBP ZNF143 +REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination LZTS1 NFIB POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K SSB +REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis APPL1 CASP3 CASP9 DAPK1 DAPK2 DAPK3 DCC MAGED1 UNC5A UNC5B +REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling DCC LOC730221 LOC730335 NTN1 PITPNA PLCG1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 +REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression ARNTL CLOCK CPT1A CREBBP EP300 HDAC3 MED1 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NPAS2 NR1D1 PPARA PPARGC1A PRIC285 RORA RXRA SMARCD3 SREBF1 TBL1X TBL1XR1 TGS1 +REACTOME_S_PHASE Genes involved in S Phase CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CCNH CDC25A CDC25B CDC45 CDC6 CDK2 CDK4 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DNA2 FEN1 GINS1 GINS2 GINS4 LIG1 LOC652826 LOC729964 MAX MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RB1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A RPS27AP11 SKP1 SKP2 UBA52 WEE1 +REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1 BTRC CDC20 CUL1 FBXO5 LOC652826 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 SKP1 UBA52 +REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21 CCNA1 CCNA2 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B CKS1B CUL1 LOC652826 LOC729964 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 RPS27A RPS27AP11 SKP1 SKP2 UBA52 +REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion CFL1 FES FYN HSP90AA1 HSP90AB1 LIMK1 LOC644816 NRP1 PAK1 PAK2 PLXNA1 PLXNA2 PLXNA3 RAC1 SEMA3A +REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion FARP2 FES FYN NRP1 PIP5K1C PLXNA1 PLXNA2 PLXNA3 RAC1 RND1 RRAS SEMA3A TLN1 +REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling ARHGAP35 ARHGEF11 ARHGEF12 CD72 CDC42 ERBB2 LIMK1 LIMK2 LOC642076 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL8P MYL9 PLXNB1 PTPRC RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK1P1 ROCK2 RRAS SEMA4D +REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse ARHGEF11 ARHGEF12 CDC42 ERBB2 LIMK1 LIMK2 LOC642076 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL8P MYL9 PLXNB1 RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK1P1 ROCK2 SEMA4D +REACTOME_SEMAPHORIN_INTERACTIONS Genes involved in Semaphorin interactions ARHGAP35 ARHGEF11 ARHGEF12 CD72 CDC42 CDK5 CDK5R1 CFL1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 ERBB2 FARP2 FES FYN HSP90AA1 HSP90AB1 ITGA1 ITGB1 LIMK1 LIMK2 LOC642076 LOC644816 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL8P MYL9 NRP1 PAK1 PAK2 PIP5K1C PLXNA1 PLXNA2 PLXNA3 PLXNB1 PLXNB3 PLXNC1 PLXND1 PTPRC RAC1 RAC2 RHOA RHOB RHOC RHOG RND1 ROCK1 ROCK1P1 ROCK2 RRAS SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A TLN1 TREM2 TYROBP +REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 +REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling CDK1 EGF EGFR GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 SHC1 SOS1 YWHAB +REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling BTC CDK1 ERBB4 EREG GRB2 HBEGF HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS NRG1 NRG2 NRG4 RAF1 SHC1 SOS1 YWHAB +REACTOME_SHC_MEDIATED_CASCADE Genes involved in SHC-mediated cascade FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 GRB2 HRAS KL KLB KRAS NRAS SHC1 SOS1 +REACTOME_SHC_MEDIATED_SIGNALLING Genes involved in SHC-mediated signalling CDK1 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 SHC1 SHC2 SHC3 SOS1 YWHAB +REACTOME_SHC_RELATED_EVENTS Genes involved in SHC-related events CDK1 GRB2 HRAS INS INSR KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 SHC1 SHC2 SHC3 SOS1 YWHAB +REACTOME_SIGNAL_AMPLIFICATION Genes involved in Signal amplification GNA11 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK14 P2RY1 P2RY12 PLA2G4A SRC TBXA2R +REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation CRK DOK1 GRB10 GRB2 INS INSR IRS1 IRS2 LOC730244 MAPK3 SHC1 SHC2 SHC3 SOS1 +REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions CD47 FYB GRB2 PTK2 PTK2B PTPN6 SIRPA SIRPB1 SIRPG SKAP2 SRC TYROBP +REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTC CSNK2A1 CSNK2A2 CSNK2B EGFR FGFR1 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 L1CAM MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NRP1 PAK1 RAC1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 SH3GL2 +REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 +REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP ACVR2A ACVR2B BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GREM2 LOC731429 NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMURF1 SMURF2 UBE2D1 UBE2D3 ZFYVE16 +REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A RPS27AP11 SHC1 SOS1 UBA52 +REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer ADAM10 ADAM12 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 BAD CALM1 CALM2 CALM3 CAMK4 CASP9 CBL CDC37 CDC42 CDK1 CDKN1A CDKN1B CHUK CLTA CLTC CREB1 CSK EGF EGFR EPN1 EPS15 EPS15L1 FOXO1 FOXO3 FOXO4 GAB1 GRB2 GSK3A HGS HRAS HSP90AA1 ITPR2 ITPR3 KRAS LOC729120 LOC730418 LOC731292 LRIG1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MTOR NR4A1 NRAS PAG1 PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3R1 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RICTOR RPS27A RPS27AP11 RPS6KB2 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 THEM4 TRIB3 TSC2 UBA52 YWHAB +REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD BTC CALM1 CALM2 CALM3 CAMK4 CASP9 CDC37 CDK1 CDKN1A CDKN1B CHUK CREB1 CUL5 EGF EGFR ERBB2 ERBB3 ERBB4 EREG FOXO1 FOXO3 FOXO4 FYN GAB1 GRB2 GRB7 GSK3A HBEGF HRAS HSP90AA1 ITPR2 ITPR3 KRAS LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MATK MDM2 MLST8 MTOR NR4A1 NRAS NRG1 NRG2 NRG4 PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3R1 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RICTOR RNF41 RPS27A RPS27AP11 RPS6KB2 SHC1 SOS1 SRC STUB1 THEM4 TRIB3 TSC2 UBA52 USP8 YES1 YWHAB +REACTOME_SIGNALING_BY_ERBB4 Genes involved in Signaling by ERBB4 ADAM17 AKT1 AKT1S1 AKT2 AKT3 APH1A APH1B BAD BTC BTRC CASP9 CDK1 CDKN1A CDKN1B CHUK CREB1 CSH1 CSN2 CUL1 CXCL12 EGF EGFR ERBB3 ERBB4 EREG ESR1 FOXO1 FOXO3 FOXO4 GFAP GH1 GH2 GHR GRB2 GSK3A HBEGF HRAS JAK2 KRAS LOC729120 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MTOR NCOR1 NCSTN NEDD4 NR4A1 NRAS NRG1 NRG2 NRG4 PDPK1 PGR PHLPP1 PIK3CA PIK3R1 PRL PRLR PSEN1 PSEN2 PSENEN PTEN RAF1 RBX1 RICTOR RPS27A RPS27AP11 RPS6KB2 S100B SH2B1 SHC1 SKP1 SOS1 STAT5A STAT5B TAB2 THEM4 TRIB3 TSC2 UBA52 WWOX WWP1 YAP1 YWHAB +REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD BRAF CALM1 CALM2 CALM3 CAMK4 CASP9 CBL CDK1 CDKN1A CDKN1B CHUK CREB1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 GAB1 GRB2 GSK3A HRAS IL17RD ITPR2 ITPR3 KL KLB KRAS LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MKNK1 MLST8 MTOR NR4A1 NRAS PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3R1 PLCG1 PPP2CA PPP2CB PPP2R1A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RICTOR RPS27A RPS27AP11 RPS6KB2 SHC1 SOS1 SPRY2 SRC THEM4 TRIB3 TSC2 UBA52 YWHAB +REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants BCR CNTRL CPSF6 CUX1 FGFR1OP FGFR1OP2 GAB2 GRB2 LOC732425 MYO18A PIK3CA PIK3R1 PLCG1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +REACTOME_SIGNALING_BY_FGFR1_MUTANTS Genes involved in Signaling by FGFR1 mutants BCR CNTRL CPSF6 CUX1 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 GAB2 GRB2 LOC732425 MYO18A PIK3CA PIK3R1 PLCG1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants FGF1 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 +REACTOME_SIGNALING_BY_FGFR_IN_DISEASE Genes involved in Signaling by FGFR in disease ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD BCR BRAF CALM1 CALM2 CALM3 CAMK4 CASP9 CBL CDK1 CDKN1A CDKN1B CHUK CNTRL CPSF6 CREB1 CUX1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FGFR2 FGFR3 FGFR4 FOXO1 FOXO3 FOXO4 FRS2 FRS3 GAB1 GAB2 GRB2 GSK3A HRAS IL17RD ITPR2 ITPR3 KL KLB KRAS LOC729120 LOC730418 LOC731292 LOC732425 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MKNK1 MLST8 MTOR MYO18A NR4A1 NRAS PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3R1 PLCG1 PPP2CA PPP2CB PPP2R1A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RICTOR RPS27A RPS27AP11 RPS6KB2 SHC1 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B THEM4 TRIB3 TRIM24 TSC2 UBA52 YWHAB ZMYM2 +REACTOME_SIGNALING_BY_FGFR_MUTANTS Genes involved in Signaling by FGFR mutants BCR CNTRL CPSF6 CUX1 FGF1 FGF10 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GAB2 GRB2 HRAS KRAS LOC732425 MYO18A NRAS PIK3CA PIK3R1 PLCG1 SOS1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 +REACTOME_SIGNALING_BY_GPCR Genes involved in Signaling by GPCR ABR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRB1 ADRB2 ADRB3 ADRBK1 AGT AGTR1 AGTR2 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLNR APP ARHGAP4 ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 CALCA CALCB CALCRL CALM1 CALM2 CALM3 CAMK4 CASR CCBP2 CCK CCKAR CCKBR CCL11 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL1P1 CD55 CD97 CDC42 CDK1 CDK5 CGA CHRM1 CHRM2 CHRM3 CHRM5 CNR1 CNR2 CREB1 CRH CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 CYSLTR1 CYSLTR2 DAGLA DAGLB DARC DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DHH DRD1 DRD2 DRD3 DRD5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB EGFR EMR1 EMR2 EMR3 F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FGD1 FGD2 FGD3 FGD4 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPBAR1 GPER GPR132 GPR17 GPR18 GPR39 GPR4 GPR44 GPR55 GPR65 GPR68 GPR77 GPRC6A GRB2 GRK5 GRM1 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 GRP GRPR HBEGF HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRAS HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH IL8 INSL3 INSL5 ITPR2 ITPR3 ITSN1 KALRN KISS1 KISS1R KNG1 KRAS LHB LHCGR LOC649279 LOC652222 LOC652292 LOC652692 LOC653879 LOC728830 LOC730002 LOC730221 LOC730335 LOC730413 LOC730418 LOC730421 LOC730808 LOC731823 LPAR1 LPAR2 LPAR3 LPAR4 LPAR6 LTB4R LTB4R2 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK7 MC1R MC2R MC3R MC4R MC5R MCF2 MCHR1 MCHR2 MGLL MLN MLNR MMP3 MTNR1A MTNR1B NET1 NGEF NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY5R NRAS NTS NTSR1 NTSR2 O3FAR1 OBSCN OPN1LW OPN1MW OPN1MW2 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A3 OR10A4 OR10A5 OR10A6 OR10A7 OR10AD1 OR10AG1 OR10C1 OR10G2 OR10G3 OR10G4 OR10G7 OR10G8 OR10G9 OR10H1 OR10H2 OR10H3 OR10H4 OR10H5 OR10J1 OR10J3 OR10J5 OR10K1 OR10K2 OR10P1 OR10Q1 OR10R2 OR10S1 OR10T2 OR10V1 OR10W1 OR10X1 OR10Z1 OR11A1 OR11G2 OR14A16 OR14C36 OR14J1 OR14K1 OR1A1 OR1A2 OR1B1 OR1C1 OR1D2 OR1D4 OR1D5 OR1E1 OR1E2 OR1F1 OR1G1 OR1I1 OR1J1 OR1J2 OR1J4 OR1K1 OR1L1 OR1L3 OR1L4 OR1L6 OR1L8 OR1M1 OR1N1 OR1N2 OR1Q1 OR1S1 OR1S2 OR2A1 OR2A12 OR2A14 OR2A2 OR2A25 OR2A4 OR2A42 OR2A5 OR2A7 OR2AE1 OR2AG1 OR2AK2 OR2B11 OR2B2 OR2B3 OR2B6 OR2C1 OR2C3 OR2D2 OR2D3 OR2F1 OR2F2 OR2G2 OR2G3 OR2G6 OR2H1 OR2J3 OR2K2 OR2L13 OR2L2 OR2L3 OR2L8 OR2M2 OR2M3 OR2M4 OR2M5 OR2M7 OR2S2 OR2T1 OR2T10 OR2T11 OR2T12 OR2T2 OR2T27 OR2T29 OR2T3 OR2T33 OR2T34 OR2T35 OR2T4 OR2T5 OR2V2 OR2W1 OR2W3 OR2Y1 OR2Z1 OR3A1 OR3A2 OR3A3 OR3A4P OR4A15 OR4A16 OR4A47 OR4A5 OR4B1 OR4C11 OR4C12 OR4C13 OR4C15 OR4C16 OR4C3 OR4C6 OR4D1 OR4D11 OR4D2 OR4D5 OR4D6 OR4D9 OR4E2 OR4F15 OR4F16 OR4F17 OR4F29 OR4F3 OR4F4 OR4F5 OR4F6 OR4K1 OR4K13 OR4K14 OR4K15 OR4K17 OR4K2 OR4K5 OR4L1 OR4M1 OR4M2 OR4N2 OR4N3P OR4N4 OR4N5 OR4P4 OR4Q3 OR4S1 OR4S2 OR4X1 OR4X2 OR51A2 OR51A4 OR51A7 OR51B2 OR51B4 OR51B5 OR51B6 OR51D1 OR51E1 OR51E2 OR51F2 OR51G1 OR51G2 OR51I1 OR51I2 OR51L1 OR51M1 OR51Q1 OR51S1 OR51T1 OR51V1 OR52A1 OR52A5 OR52B4 OR52B6 OR52D1 OR52E2 OR52E4 OR52E6 OR52E8 OR52H1 OR52I1 OR52I2 OR52J3 OR52K1 OR52K2 OR52L1 OR52M1 OR52N1 OR52N2 OR52N4 OR52N5 OR52R1 OR52W1 OR56A1 OR56A3 OR56A4 OR56B1 OR56B4 OR5A1 OR5A2 OR5AC2 OR5AK2 OR5AN1 OR5AP2 OR5AR1 OR5AS1 OR5AU1 OR5B12 OR5B17 OR5B2 OR5B3 OR5C1 OR5D13 OR5D14 OR5D16 OR5D18 OR5F1 OR5H2 OR5H6 OR5I1 OR5J2 OR5K1 OR5K2 OR5L1 OR5L2 OR5M3 OR5M8 OR5M9 OR5P2 OR5P3 OR5R1 OR5T1 OR5T2 OR5T3 OR5V1 OR5W2 OR6A2 OR6B1 OR6B2 OR6B3 OR6C1 OR6C2 OR6C3 OR6C4 OR6F1 OR6K2 OR6K3 OR6K6 OR6M1 OR6N1 OR6N2 OR6Q1 OR6S1 OR6T1 OR6V1 OR6X1 OR6Y1 OR7A10 OR7A17 OR7A5 OR7C1 OR7C2 OR7D2 OR7D4 OR7G1 OR7G2 OR7G3 OR8A1 OR8B12 OR8B3 OR8B4 OR8B8 OR8D1 OR8D2 OR8D4 OR8H1 OR8H2 OR8H3 OR8I2 OR8J1 OR8J3 OR8K1 OR8K3 OR8K5 OR8S1 OR8U1 OR8U8 OR8U9 OR9A2 OR9A4 OR9G1 OR9G4 OR9G9 OR9I1 OR9K2 OR9Q1 OR9Q2 OXER1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLXNB1 PMCH PNOC POMC PPBP PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3R1 PPY PPYR1 PREX1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRLH PRLHR PROK1 PROKR1 PROKR2 PTAFR PTCH1 PTCH2 PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAC1 RAC2 RAF1 RAMP1 RAMP2 RAMP3 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS11 RGS12 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS4 RGS6 RGS7 RGS8 RGS9 RHO RHOA RHOB RHOC RHOG RLN2 RLN3 ROCK1 ROCK1P1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHH SMO SOS1 SOS2 SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR UTS2 UTS2D UTS2R VAV1 VAV3 VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 YWHAB +REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo AMOT AMOTL1 AMOTL2 CASP3 DVL2 LATS1 LATS2 LOC440917 LOC646561 MOB1A MOB1B NPHP4 SAV1 STK3 STK4 TJP1 TJP2 WWC1 WWTR1 YAP1 YWHAB YWHAE +REACTOME_SIGNALING_BY_ILS Genes involved in Signaling by Interleukins BLNK BTRC CASP1 CBL CDK1 CHUK CRK CRKL CSF2 CSF2RA CSF2RB CUL1 FYN GAB2 GRB2 HCK HGF HRAS IKBKB IKBKG IL18 IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R INPPL1 IRAK1 IRAK2 IRAK3 IRAK4 JAK1 JAK2 JAK3 KRAS LCK LOC649891 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK3 MYD88 NFKB2 NOD1 NOD2 NRAS PELI1 PELI2 PELI3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACB PTK2B PTPN6 RAF1 RAPGEF1 RBX1 RELA RIPK2 SHC1 SKP1 SOCS3 SOS1 SQSTM1 STAT1 STAT3 STAT5A STAT5B SYK TAB1 TAB2 TAB3 TEC TMEM189-UBE2V1 TNIP2 TOLLIP TRAF6 TYK2 UBE2N VAV1 YES1 YWHAB YWHAZ +REACTOME_SIGNALING_BY_INSULIN_RECEPTOR Genes involved in Signaling by Insulin receptor AKT2 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CAB39 CAB39L CDK1 CRK DOK1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FGF1 FGF10 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB10 GRB2 HRAS INS INSR IRS1 IRS2 KL KLB KRAS LOC644462 LOC729120 LOC730244 MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAF1 RHEB RPS6 RPS6KB1 RPTOR SHC1 SHC2 SHC3 SOS1 STK11 STRADA STRADB TCIRG1 THEM4 TLR9 TRIB3 TSC1 TSC2 YWHAB +REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL ACVR1B ACVR1C ACVR2A ACVR2B CER1 DRAP1 FOXH1 FOXO3 FURIN GDF1 LEFTY1 LEFTY2 NODAL PCSK6 SMAD2 SMAD3 SMAD4 TDGF1 +REACTOME_SIGNALING_BY_NOTCH Genes involved in Signaling by NOTCH ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCNC CCND1 CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 E2F1 E2F3 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EP300 FBXW7 FURIN HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A JAG1 JAG2 JUN KAT2A KAT2B LFNG LOC441488 LOC728030 MAML1 MAML2 MAML3 MAMLD1 MFNG MIB1 MIB2 MOV10 MYC NCOR1 NCOR2 NCSTN NEURL NOTCH2 NOTCH3 NOTCH4 NUMB POFUT1 POGLUT1 PSEN1 PSEN2 PSENEN RAB6A RBPJ RBX1 RFNG RPS27A RPS27AP11 SEL1L SKP1 SNW1 ST3GAL3 ST3GAL6 TBL1X TBL1XR1 TFDP1 TLE1 TLE2 TLE3 TLE4 TMED2 TNRC6A TNRC6B TNRC6C TP53 UBA52 +REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1 ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A JAG1 JAG2 KAT2A KAT2B LOC728030 MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL NUMB PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A RPS27AP11 SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 +REACTOME_SIGNALING_BY_NOTCH2 Genes involved in Signaling by NOTCH2 ADAM10 APH1A APH1B DLL1 DLL4 JAG1 JAG2 NCSTN NOTCH2 PSEN1 PSEN2 PSENEN +REACTOME_SIGNALING_BY_NOTCH3 Genes involved in Signaling by NOTCH3 ADAM10 APH1A APH1B DLL1 DLL4 JAG1 JAG2 NCSTN NOTCH3 PSEN1 PSEN2 PSENEN +REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4 ADAM10 APH1A APH1B DLL1 DLL4 JAG1 JAG2 NCSTN NOTCH4 PSEN1 PSEN2 PSENEN +REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRBK1 AKT1 AKT1S1 AKT2 AKT3 BAD BCAR1 CALM1 CALM2 CALM3 CAMK4 CASP9 CDK1 CDKN1A CDKN1B CHUK COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 CREB1 CRK CRKL FOXO1 FOXO3 FOXO4 FURIN GRB2 GRB7 GSK3A HRAS ITPR2 ITPR3 KRAS LOC729030 LOC729120 LOC730418 LOC731292 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MTOR NCK1 NCK2 NR4A1 NRAS PDE1A PDE1B PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDPK1 PHLPP1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLAT PLCG1 PLG PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PTEN RAF1 RAPGEF1 RASA1 RICTOR RPS6KB2 SOS1 SPP1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THBS1 THBS2 THBS3 THBS4 THEM4 TRIB3 TSC2 YWHAB +REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases A2M ABR AKAP13 ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP22 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP35 ARHGAP36 ARHGAP4 ARHGAP40 ARHGAP44 ARHGAP6 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 BCR CDC42 CHN1 CHN2 DEPDC1B DEPDC7 DLC1 ECT2 FAM13A FAM13B FGD1 FGD2 FGD3 FGD4 G3BP2 GDI1 GDI2 GMIP HMHA1 ITSN1 KALRN LOC732425 MCF2 MYO9B NET1 NGEF OBSCN OCRL OPHN1 PIK3R2 PLEKHG2 PREX1 PRR5-ARHGAP8 RAC1 RAC2 RAC3 RACGAP1 RALBP1 RASGRF1 RASGRF2 RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOT1 RHOT2 RHOV SOS1 SOS2 SRGAP1 SRGAP2 SRGAP3 STARD13 STARD8 SYDE1 SYDE2 TAGAP TIAM1 TIAM2 TRIO VAV1 VAV3 +REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor ABL1 ABL2 CAP1 CAP2 CDC42 CLASP1 ENAH EVL GPC1 LOC729030 NCK1 NCK2 PAK1 PAK2 PAK4 PAK6 PAK7 PFN1 PFN2 RAC1 ROBO1 ROBO2 ROBO3 SLIT2 SOS1 SOS2 SRGAP1 SRGAP2 SRGAP3 VASP +REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CBL CDK1 CDKN1A CDKN1B CHEK1 CHUK CMA1 CREB1 FER FES FOXO1 FOXO3 FOXO4 FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 GSK3A HRAS JAK2 KIT KITLG KRAS LCK LOC653882 LOC729120 LOC731292 LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MAPKAP1 MDM2 MLST8 MMP9 MTOR NR4A1 NRAS PDPK1 PHLPP1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PRKCA PTEN PTPN6 RAC1 RAF1 RICTOR RPS6KB2 SH2B2 SH2B3 SOCS1 SOCS6 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC THEM4 TRIB3 TSC2 VAV1 YES1 YWHAB +REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX Genes involved in Signaling by TGF-beta Receptor Complex ARHGEF18 CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B CGN E2F4 E2F5 F11R FKBP1A FURIN HDAC1 JUNB LOC441488 LOC731429 MEN1 MTMR4 MYC NCOR1 NCOR2 PARD3 PARD6A PARP1 PMEPA1 PPM1A PPP1CA PPP1CB PPP1CC PPP1R15A PRKCZ RBL1 RHOA RPS27A RPS27AP11 SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SP1 STRAP STUB1 TFDP1 TGFB1 TGFBR1 TGFBR2 TGIF1 TGIF2 TRIM33 UBA52 UBE2D1 UBE2D3 UCHL5 USP9X WWTR1 XPO1 ZFYVE9 +REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR Genes involved in Signaling by the B Cell Receptor (BCR) AKT1 AKT1S1 AKT2 AKT3 BAD BCL10 BLK BLNK BTK BTRC CALM1 CALM2 CALM3 CARD11 CASP9 CBL CBLB CD19 CD79A CD79B CDKN1A CDKN1B CHUK CREB1 CUL1 FBXW11 FOXO1 FOXO3 FOXO4 FYN GRB2 GSK3A HRAS IKBKB IKBKG ITPR2 ITPR3 KRAS LOC646626 LOC652826 LOC729120 LOC731292 LYN MALT1 MAP3K7 MAPKAP1 MDM2 MLST8 MTOR NCK1 NFKBIA NFKBIB NFKBIE NR4A1 NRAS ORAI1 PDPK1 PHLPP1 PIK3AP1 PIK3CD PIK3R1 PLCG1 PLCG2 PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTEN RASGRP1 RASGRP3 REL RELA RICTOR RPS27A RPS27AP11 RPS6KB2 SH3KBP1 SHC1 SKP1 SOS1 STIM1 SYK THEM4 TRIB3 TSC2 UBA52 VAV1 +REACTOME_SIGNALING_BY_WNT Genes involved in Signaling by Wnt APC AXIN1 BTRC CSNK1A1 CTNNB1 CUL1 FAM123B FRAT1 FRAT2 LOC652826 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RPS27AP11 SKP1 UBA52 +REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF AATF ABR ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADORA2A ADRBK1 AKAP13 AKT1 AKT1S1 AKT2 AKT3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B ARHGAP4 ARHGDIA ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF6 ARHGEF9 ATF1 BAD BCL2L11 BRAF CALM1 CALM2 CALM3 CAMK4 CASP2 CASP3 CASP9 CDK1 CDKN1A CDKN1B CHUK CLTA CLTC CREB1 CRK DNAL4 DNM1 DNM2 DUSP3 DUSP4 DUSP6 DUSP7 ECT2 ELK1 FGD1 FGD2 FGD3 FGD4 FOXO1 FOXO3 FOXO4 FRS2 FURIN GRB2 GSK3A HDAC1 HDAC2 HDAC3 HRAS IKBKB IRAK1 IRS1 IRS2 ITGB3BP ITPR2 ITPR3 ITSN1 KALRN KIDINS220 KRAS LINGO1 LOC440917 LOC729120 LOC730418 LOC731292 MAG MAGED1 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPKAP1 MAPKAPK2 MAPKAPK3 MCF2 MDM2 MEF2A MEF2C MLST8 MTOR MYD88 NCSTN NET1 NFKBIA NGEF NGF NGFR NGFRAP1 NR4A1 NRAS NTRK1 NTRK2 OBSCN OMG PCSK5 PCSK6 PDE1A PDE1B PDPK1 PHLPP1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLEKHG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRDM4 PREX1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PRKCI PSEN1 PSEN2 PSENEN PTEN RAC1 RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RASGRF1 RASGRF2 RELA RHOA RICTOR RIPK2 RIT1 RIT2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KB2 RTN4 SH3GL2 SHC1 SHC2 SHC3 SMPD2 SORCS3 SOS1 SOS2 SQSTM1 SRC STAT3 THEM4 TIAM1 TIAM2 TRAF6 TRIB3 TRIO TSC2 UBA52 VAV1 VAV3 YWHAB YWHAE +REACTOME_SIGNALLING_TO_ERKS Genes involved in Signalling to ERKs BRAF CDK1 CRK FRS2 GRB2 HRAS KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 PLCG1 RAF1 RALA RALB RALGDS RAP1A RAPGEF1 RIT1 RIT2 SHC1 SHC2 SHC3 SOS1 SRC YWHAB +REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN BRAF CDK1 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NRAS NTRK1 RAF1 RIT1 RIT2 YWHAB +REACTOME_SIGNALLING_TO_RAS Genes involved in Signalling to RAS CDK1 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 RAF1 RALA RALB RALGDS SHC1 SHC2 SHC3 SOS1 SRC YWHAB +REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs LSM10 LSM11 NCBP1 NCBP2 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 +REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT Genes involved in SLC-mediated transmembrane transport AAAS ALB AVP CP G6PC G6PC2 G6PC3 GCK GCKR HEPH HK1 HK2 HK3 LOC652661 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 RAE1 RANBP2 RHAG RHCG SEH1L SLC10A6 SLC11A1 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC13A1 SLC13A2 SLC13A3 SLC13A5 SLC14A1 SLC14A2 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A1 SLC16A10 SLC16A3 SLC16A7 SLC16A8 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC18A1 SLC18A2 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A6 SLC26A7 SLC26A9 SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A7 SLC30A8 SLC31A1 SLC32A1 SLC33A1 SLC34A1 SLC34A2 SLC34A3 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC36A1 SLC36A2 SLC37A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC39A1 SLC39A10 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC3A1 SLC3A2 SLC40A1 SLC41A1 SLC41A2 SLC43A1 SLC43A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC47A1 SLC47A2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC6A1 SLC6A11 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 TPR +REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B E2F4 E2F5 HDAC1 JUNB LOC441488 MEN1 MYC RBL1 RPS27A RPS27AP11 SERPINE1 SMAD2 SMAD3 SMAD4 SMAD7 SP1 TFDP1 TGIF1 TGIF2 UBA52 WWTR1 +REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction ACTA2 ACTG2 CALD1 CALM1 CALM2 CALM3 ITGA1 ITGB5 LMOD1 LOC642076 MYH11 MYL12B MYL6 MYL6B MYL8P MYL9 MYLK SORBS1 SORBS3 TLN1 TPM1 TPM2 TPM3 TPM4 VCL +REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling CDK1 GRB2 HRAS IRS1 IRS2 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS RAF1 SOS1 YWHAB +REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis ACER1 ACER2 ACER3 CERS2 CERS3 CERS4 CERS5 CERS6 COL4A3BP CSNK1G2 DEGS1 DEGS2 KDSR LOC729155 OSBP PPAP2A PPAP2B PPAP2C PPM1L PRKD1 SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SPHK1 SPHK2 SPTLC1 SPTLC2 VAPA VAPB +REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism ACER1 ACER2 ACER3 ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 ASAH2C CERK CERS2 CERS3 CERS4 CERS5 CERS6 COL4A3BP CSNK1G2 CTSA DEGS1 DEGS2 ENPP7 GAL3ST1 GALC GBA GBA2 GBA3 GLA GLB1 GM2A HEXA HEXB KDSR LOC729155 NEU1 NEU2 NEU3 NEU4 OSBP PPAP2A PPAP2B PPAP2C PPM1L PRKD1 PSAP SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPTLC1 SPTLC2 STS SUMF1 SUMF2 UGCG VAPA VAPB +REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling BRAF CBL GRB2 MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A RPS27A RPS27AP11 SPRY2 SRC UBA52 +REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane DDOST FAM153A FAU LOC641895 LOC646184 LOC647074 LOC649602 LOC650638 LOC651825 LOC651894 LOC653566 LOC653881 LOC730343 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRP9P1 SRPR SRPRB SSR1 SSR2 SSR3 SSR4 TRAM1 UBA52 +REACTOME_STEROID_HORMONES Genes involved in Steroid hormones AKR1B1 CGA CUBN CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 CYP24A1 CYP27B1 CYP2R1 GC HSD11B1 HSD17B1 HSD17B3 HSD3B1 HSD3B2 LGMN LHB LRP2 POMC SRD5A1 SRD5A2 SRD5A3 STAR STARD4 STARD5 STARD6 +REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction ACTN2 DES DMD MYBPC1 MYBPC2 MYH3 MYH6 MYH8 MYL1 MYL2 MYL3 MYL4 NEB TCAP TMOD1 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TPM1 TPM2 TPM3 TPM4 VIM +REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism ADI1 AHCY APIP BHMT CBS CDO1 CNDP2 CSAD CTH ENOPH1 ETHE1 GCLC GCLM GOT1 MAT1A MAT2A MAT2B MRI1 MTAP MTR SLC25A10 SQRDL SUOX TST +REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates AK1 AK2 AK5 CMPK1 CTPS CTPS2 DTYMK GLRX GSR GUK1 NME1 NME1-NME2 NME2 NME4 RRM1 RRM2 RRM2B TXN TXNRD1 +REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS Genes involved in Synthesis of bile acids and bile salts ABCB11 ACOT8 ACOX2 AKR1C4 AKR1D1 AMACR BAAT CH25H CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 SCP2 SLC27A2 SLC27A5 +REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol AKR1C4 AKR1D1 AMACR CYP27A1 CYP39A1 CYP46A1 CYP8B1 HSD3B7 SLC27A2 SLC27A5 +REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol ABCB11 ACOT8 ACOX2 AKR1C4 AKR1D1 AMACR BAAT CYP27A1 CYP7A1 CYP8B1 HSD17B4 HSD3B7 SCP2 SLC27A2 SLC27A5 +REACTOME_SYNTHESIS_OF_DNA Genes involved in Synthesis of DNA CCNA1 CCNA2 CDC45 CDC6 CDK2 CDKN1A CDKN1B CDT1 DNA2 FEN1 GINS1 GINS2 GINS4 LIG1 LOC652826 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RB1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A RPS27AP11 UBA52 +REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) DPM2 PIGA PIGB PIGC PIGF PIGG PIGH PIGL PIGM PIGN PIGO PIGP PIGQ PIGV PIGW PIGX SEMA6D +REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 GNPAT GPAM GPAT2 GPD1 GPD1L LCLAT1 LPCAT1 LPCAT4 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4D PLA2G5 PLD1 PLD2 +REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC ACHE CEPT1 CHAT CHKA CHKB CHPT1 LPIN1 LPIN2 LPIN3 PCYT1A PCYT1B PEMT PHOSPHO1 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 +REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE CEPT1 CHKA CHKB EPT1 ETNK1 ETNK2 LPIN1 LPIN2 LPIN3 PCYT2 PHOSPHO1 +REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane FIG4 INPP4B MTM1 MTMR2 MTMR4 PI4K2A PI4K2B PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 +REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane ARF1 ARF3 FIG4 INPP5E OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2G PIK3C3 PIK3R4 PIKFYVE SACM1L TPTE2 VAC14 +REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane FIG4 MTM1 MTMR2 MTMR4 MTMR7 PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 +REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane INPP4B INPP5J INPP5K INPPL1 LOC731292 MTM1 MTMR1 MTMR14 MTMR3 MTMR6 PI4K2A PI4K2B PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP5K1B PIP5K1C PTEN SYNJ1 SYNJ2 +REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis ALG5 DOLK DOLPP1 DPM1 DPM2 DPM3 GFPT2 GMPPA GMPPB GNPNAT1 MPI PGM3 PMM1 PMM2 +REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 HSD17B12 TECR +REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin BCHE GCG GH1 GHRL INS KLF4 LEP LOC653566 MBOAT4 PCSK1 PLA2G7 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) DPP4 FFAR1 GATA4 GIP GPR119 ISL1 LOC653566 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) CDX2 CTNNB1 DPP4 FFAR1 GCG GNB3 GNG13 GPR119 GRP LEP LOC653566 O3FAR1 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 +REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex AGER APP CHUK HMGB1 IKBKB IKBKG IRAK1 IRAK2 MAP3K7 NFKB2 NFKBIA NFKBIB NOD1 NOD2 RELA RIPK2 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TRAF6 +REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels KCNK1 KCNK10 KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK6 KCNK7 KCNK9 +REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport ACO2 ADHFE1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6 ATP8 BSG COX1 COX2 COX3 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2L COX7B COX7C COX8A CS CYC1 CYCS CYTB D2HGDH DLAT DLD DLST ETFA ETFB ETFDH FH IDH1 IDH2 IDH3A IDH3B IDH3G L2HGDH LDHA LDHB LOC283398 LOC642727 LOC646675 LOC646677 LOC650667 LOC650674 LOC650883 LOC651820 LOC727947 MDH2 MTND5P10 ND1 ND2 ND3 ND4 ND4L ND5 ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB10 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NNT OGDH PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR SDHA SDHB SDHC SDHD SLC16A1 SLC16A3 SLC16A8 SUCLA2 SUCLA2P1 SUCLG1 SUCLG2 UCP1 UCP2 UCP3 UQCR11 UQCRB UQCRBP1 UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ +REACTOME_TCR_SIGNALING Genes involved in TCR signaling BCL10 CARD11 CD247 CD3D CD3E CD3G CD4 CHUK CSK ENAH EVL FYB GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 IKBKB IKBKG ITK LAT LCK LCP2 LOC646626 LOC731292 MALT1 MAP3K7 NCK1 NFKBIA PAG1 PAK1 PAK2 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKCQ PTEN PTPRC RELA RIPK2 TAB2 TMEM189-UBE2V1 TRAF6 TRAT1 UBE2N VASP WAS ZAP70 +REACTOME_TELOMERE_MAINTENANCE Genes involved in Telomere Maintenance ACD DKC1 DNA2 FEN1 H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 LIG1 NHP2 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POT1 PRIM1 PRIM2 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RUVBL1 RUVBL2 TERF1 TERF2 TERF2IP TERT TINF2 WRAP53 +REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis LOC652741 LOC732162 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC21 MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 +REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation AKT1 CALM1 CALM2 CALM3 DHFR DHFRP1 GCH1 GCHFR HSP90AA1 NOS3 PRKG2 PTS SPR +REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS Genes involved in TGF-beta receptor signaling activates SMADs FKBP1A FURIN LOC731429 MTMR4 PMEPA1 PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A RPS27AP11 SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA52 UCHL5 XPO1 ZFYVE9 +REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) ARHGEF18 CGN F11R FKBP1A LOC731429 PARD3 PARD6A PRKCZ RHOA RPS27A RPS27AP11 SMURF1 TGFB1 TGFBR1 TGFBR2 UBA52 +REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases ARSA ARSB ARSE ARSF ARSG ARSH ARSI ARSJ ARSK STS SUMF1 SUMF2 +REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome APP CASP1 HSP90AB1 LOC644816 MEFV NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD TXN TXNIP +REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD247 CD28 CD4 CD8B DOCK2 ELMO1 FYN HCK HLA-A HLA-K LCK PACS1 PAK2 RAC1 +REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs) ARRB1 ARRB2 F2 F2R F2RL2 F2RL3 GNA11 GNA12 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK1 MAPK3 SRC +REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor GNA11 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 TBXA2R +REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling ANGPT1 ANGPT2 ANGPT4 DOK2 GRB14 GRB2 GRB7 HRAS KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 SHC1 SOS1 TEK +REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 F11R INADL MPP5 PARD3 PARD6A PARD6B PARD6G PRKCI +REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades AGER APP ATF1 ATF2 BTK CD14 CD180 CDK1 CHUK CNPY3 CREB1 CTSB CTSK CTSL1 CTSS DNM1 DNM2 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT EEA1 ELK1 FOS HMGB1 HSP90B1 IKBKB IKBKE IKBKG IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 JUN LBP LGMN LOC650832 LY86 LY96 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PIK3C3 PIK3R4 PLCG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK1 RIPK2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 SIGIRR TAB1 TAB2 TAB3 TBK1 TICAM1 TICAM2 TIRAP TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TMEM189-UBE2V1 TRAF3 TRAF6 UBA52 UBE2N UNC93B1 UNC93B2 UNC93B6 ZFYVE20 +REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway CREBBP DDX58 EP300 IFIH1 IFNB1 IKBKE IRF3 IRF7 MAVS RNF135 SIKE1 TBK1 TRAF3 TRIM25 +REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ECSIT ELK1 FOS HMGB1 IKBKB IKBKG IRAK1 IRAK2 IRAK4 JUN LOC650832 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MYD88 NFKB2 NFKBIA NFKBIB NOD1 NOD2 PELI1 PELI2 PELI3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK2 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TLR7 TLR8 TLR9 TMEM189-UBE2V1 TRAF6 UBA52 UBE2N +REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex CD14 LY96 MAP3K7 RPS27A RPS27AP11 TAB1 TAB2 TAB3 TICAM1 TICAM2 TLR3 TLR4 TRAF6 UBA52 +REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation CREBBP DDX58 EP300 IFIH1 IFNA1 IFNA10 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKE IRF1 IRF2 IRF3 IRF7 MAVS RNF135 SIKE1 TANK TBK1 TRAF2 TRAF6 TRIM25 +REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 IRAK4 IRF7 MYD88 TLR7 TLR8 TLR9 TMEM189-UBE2V1 TRAF6 UBE2N +REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation AGER APP CHUK DDX58 HMGB1 IFIH1 IKBKB IKBKG MAP3K1 MAVS NFKB2 NFKBIA NFKBIB RELA RNF135 S100A12 S100B SAA1 TRAF2 TRAF6 TRIM25 +REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR CNPY3 CTSB CTSK CTSL1 CTSS HSP90B1 LGMN TLR3 TLR7 TLR8 TLR9 UNC93B1 UNC93B2 UNC93B6 +REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors AKAP5 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CACNG2 CACNG3 CACNG4 CACNG8 CAMK2A CAMK2B CAMK2D DLG1 EPB41L1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP2 LOC651907 MDM2 MYO6 NSF PICK1 PRKCA PRKCB PRKCG +REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP2 LOC651907 NSF PICK1 PRKCA PRKCB PRKCG +REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING Genes involved in trans-Golgi Network Vesicle Budding AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP3B1 AP3S1 AP4B1 AP4E1 ARF1 ARRB1 BLOC1S1 BLOC1S3 CLTA CLTC CNO CPD CTSZ DNAJC6 DNASE2 DNM2 DTNBP1 FTH1 FTL GAK GBF1 GNS HIP1R HSPA8 IGF2R LOC643454 M6PR NAPA NECAP1 OCRL PICALM PIK3C2A PLDN PUM1 RAB5C SH3D19 SH3GL2 SNAP23 SNAPIN SNX2 SNX5 SNX9 SORT1 STX4 TBC1D8B TFRC TGOLN2 TPD52 TPD52L1 TXNDC5 VAMP2 VAMP7 VAMP8 YIPF6 +REACTOME_TRANSCRIPTION Genes involved in Transcription BRF1 BRF2 CBX3 CCNH CCNT1 CCNT2 CDC40 CDK7 CDK9 CLP1 COBRA1 CPSF1 CPSF2 CPSF3 CPSF7 CSTF1 CSTF2 CSTF3 CTDP1 DHX38 EHMT2 ELL ERCC2 ERCC3 ERCC6 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H2AFX H2AFZ H3F3A H3F3AP5 H3F3AP6 H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 KAT2B LOC643446 LOC652857 LOC653972 LOC731820 LSM10 LSM11 LZTS1 MAGOH MAPK3 MBD2 MNAT1 MTERF NCBP1 NCBP2 NFIB NFX1 NUDT21 PABPN1 PAPOLA PCF11 POLR1A POLR1B POLR1C POLR1D POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3GL POLR3H POLR3K POLRMT POU2F1 PTRF RBM8A RDBP RNGTT RNMT RNPS1 RRN3 SLBP SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SSB SSRP1 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF4 TAF4B TAF5 TAF6 TAF9 TBP TCEA1 TCEB1 TCEB1P3 TCEB2 TCEB3 TFAM TFB2M TH1L THOC4 U2AF1 U2AF2 UBTF UPF3B WHSC2 ZNF143 ZNF473 +REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER Genes involved in Transcription-coupled NER (TC-NER) CCNH CDK7 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 GTF2H1 GTF2H2 GTF2H2B GTF2H3 GTF2H4 LIG1 LOC652857 MNAT1 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 TCEA1 XAB2 +REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer CCNC CCNT1 CCNT2 CDK8 CDK9 CDKN2B E2F4 E2F5 HDAC1 JUNB LOC441488 MEN1 MYC NCOR1 NCOR2 PARP1 PPM1A RBL1 RPS27A RPS27AP11 SERPINE1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SP1 TFDP1 TGIF1 TGIF2 TRIM33 UBA52 UBE2D1 UBE2D3 USP9X WWTR1 +REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation ADIPOQ ANGPTL4 CCNC CCND3 CD36 CDK19 CDK4 CDK8 CEBPB CEBPD CREBBP EBF1 EGR2 EP300 FABP4 HDAC3 KLF4 KLF5 LEP LPL MED1 MED10 MED11 MED12 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F2 PCK1 PLIN1 PPARA PPARG PPARGC1A PRIC285 RELA RXRA SLC2A4 SMARCD3 SREBF1 TBL1X TBL1XR1 TGFB1 TGS1 TNF WNT1 WNT10B +REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H MCOLN1 STEAP3 TCIRG1 TF TFRC +REACTOME_TRANSLATION Genes involved in Translation DDOST EEF1A1 EEF1B2 EEF1D EEF1DP1 EEF1G EEF2 EIF1AX EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3FP3 EIF3G EIF3H EIF3I EIF3J EIF3K EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H EIF5 EIF5B ETF1 FAM153A FAU GSPT2 LOC641895 LOC646184 LOC647030 LOC647074 LOC649602 LOC650638 LOC651825 LOC651894 LOC652607 LOC653566 LOC653881 LOC653994 LOC729998 LOC730343 PABPC1 RPL10 RPL10A RPL10P16 RPL10P9 RPL11 RPL12 RPL12P2 RPL13 RPL13A RPL14 RPL15 RPL15P17 RPL17 RPL17P36 RPL17P6 RPL18 RPL18A RPL19 RPL19P9 RPL21 RPL21P119 RPL21P134 RPL21P16 RPL21P29 RPL21P75 RPL22 RPL22P11 RPL23 RPL23A RPL23AP18 RPL23AP2 RPL23AP42 RPL23AP63 RPL23AP74 RPL24 RPL26 RPL26L1 RPL26P22 RPL26P24 RPL26P30 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL31P17 RPL31P31 RPL32 RPL32P16 RPL34 RPL34P27 RPL34P31 RPL35 RPL35A RPL36 RPL36A RPL36AP23 RPL36AP31 RPL36AP37 RPL36AP51 RPL36AP8 RPL36P14 RPL37 RPL37A RPL38 RPL39 RPL3L RPL4 RPL41 RPL5 RPL5P1 RPL6 RPL6P19 RPL7 RPL7A RPL7AP27 RPL7AP66 RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPS10 RPS10P9 RPS11 RPS12 RPS12P22 RPS12P4 RPS13 RPS13P8 RPS14 RPS15 RPS15A RPS15AP11 RPS15P5 RPS16 RPS17 RPS18 RPS18P10 RPS18P5 RPS19 RPS19P3 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS26P10 RPS26P20 RPS26P25 RPS26P28 RPS26P35 RPS26P50 RPS26P7 RPS27 RPS27A RPS27AP11 RPS28 RPS28P4 RPS28P7 RPS28P9 RPS29 RPS29P3 RPS3 RPS3A RPS4X RPS4Y1 RPS5 RPS6 RPS7 RPS8 RPS8P10 RPS9 RPSA RPSAP12 RPSAP9 SEC11A SEC11C SEC61A1 SEC61A2 SEC61B SEC61G SPCS1 SPCS2 SPCS3 SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRP9P1 SRPR SRPRB SSR1 SSR2 SSR3 SSR4 TRAM1 UBA52 +REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse CD247 CD3D CD3E CD3G CD4 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DRB1 HLA-DRB3 HLA-DRB5 LCK ZAP70 +REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES Genes involved in Transmembrane transport of small molecules AAAS ABCA10 ABCA12 ABCA2 ABCA3 ABCA4 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB5 ABCB6 ABCC1 ABCC11 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 ABCD1P5 ABCD2 ABCD3 ABCG1 ABCG2 ABCG4 ABCG5 ABCG8 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ALB APOA1 AQP1 AQP10 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 ARHGEF9 ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B2 ATP2B3 ATP2C1 ATP2C2 ATP4A ATP4B ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B3 ATP8B4 ATP9A ATP9B AVP AVPR2 CFTR CP CYBRD1 FLVCR1 FTH1 FTL FXYD2 G6PC G6PC2 G6PC3 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GCK GCKR GLRA1 GLRA2 GLRA3 GLRB GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HEPH HK1 HK2 HK3 HMOX1 HMOX2 HTR3A HTR3B HTR3C LOC644732 LOC652661 LOC730418 MCOLN1 MIP MYO5B NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 PEX19 PEX3 POM121 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 RAE1 RANBP2 RHAG RHCG SEH1L SLC10A6 SLC11A1 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC13A1 SLC13A2 SLC13A3 SLC13A5 SLC14A1 SLC14A2 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A1 SLC16A10 SLC16A3 SLC16A7 SLC16A8 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC18A1 SLC18A2 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A6 SLC26A7 SLC26A9 SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A7 SLC30A8 SLC31A1 SLC32A1 SLC33A1 SLC34A1 SLC34A2 SLC34A3 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC36A1 SLC36A2 SLC37A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC39A1 SLC39A10 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC3A1 SLC3A2 SLC40A1 SLC41A1 SLC41A2 SLC43A1 SLC43A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC46A1 SLC47A1 SLC47A2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC6A1 SLC6A11 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 STEAP3 TCIRG1 TF TFRC TPR +REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses ABAT ACHE ACTN2 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP5 AKAP9 ALDH2 ALDH5A1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARHGEF9 BRAF CACNA1A CACNA1B CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG3 CACNG4 CACNG8 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK4 CAMKK1 CHAT CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG COMT CREB1 DLG1 DLG3 DNAJC5 EPB41L1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRR1 GABRR2 GAD1 GAD2 GLS GLS2 GLUL GNAI1 GNAI2 GNAI3 GNAL GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIP2 HRAS HSPA8 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 LOC651907 LOC732445 MAOA MAPK1 MDM2 MYO6 NCALD NEFL NSF PDPK1 PICK1 PLCB1 PLCB2 PLCB3 PRKACB PRKCA PRKCB PRKCG RAB3A RAF1 RASGRF1 RASGRF2 RIMS1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RRAS SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC22A2 SLC32A1 SLC38A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A3 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 UNC13B VAMP2 +REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds CP HEPH RHAG RHCG SLC10A6 SLC11A1 SLC13A1 SLC13A2 SLC13A3 SLC13A5 SLC14A1 SLC14A2 SLC16A1 SLC16A3 SLC16A7 SLC16A8 SLC18A1 SLC18A2 SLC22A1 SLC22A11 SLC22A12 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC2A1 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A7 SLC30A8 SLC31A1 SLC39A1 SLC39A10 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC40A1 SLC41A1 SLC41A2 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 SLC47A1 SLC47A2 SLC5A1 SLC5A11 SLC5A2 SLC5A3 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 +REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides LOC652661 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC15A1 SLC15A2 SLC15A3 SLC15A4 SLC16A10 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 SLC20A1 SLC20A2 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6 SLC25A10 SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A6 SLC26A7 SLC26A9 SLC32A1 SLC34A1 SLC34A2 SLC34A3 SLC36A1 SLC36A2 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 SLC5A5 SLC5A8 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A2 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 +REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript AAAS CPSF1 CPSF2 CPSF3 EIF4E NCBP1 NCBP2 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 SEH1L THOC4 TPR +REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm AAAS CDC40 CPSF1 CPSF2 CPSF3 DHX38 EIF4E LOC643446 MAGOH NCBP1 NCBP2 NFX1 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 NXF1 POM121 RAE1 RANBP2 RBM8A RNPS1 SEH1L SLBP SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 THOC4 TPR U2AF1 U2AF2 UPF3B +REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions ALB AVP SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 +REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus AAAS KPNA1 KPNB1 NUP107 NUP133 NUP153 NUP155 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUPL1 NUPL2 POM121 RAE1 RANBP2 SEH1L TPR +REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules ALB AVP SLC27A1 SLC27A4 SLC27A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4 SLC33A1 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B4 SLC35C1 SLC35D1 SLC35D2 SLC5A6 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 +REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 FUT8 LMAN1 MAN1A1 MAN1A2 MAN1C1 MAN2A1 MANEA MCFD2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT4C MGAT5 PREB SAR1B SEC13 SEC23A SEC24B SEC24C SEC24D SEC31A ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6 +REACTOME_TRIF_MEDIATED_TLR3_SIGNALING Genes involved in TRIF mediated TLR3 signaling AGER APP ATF1 ATF2 CDK1 CHUK CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS HMGB1 IKBKB IKBKE IKBKG IRAK1 IRAK2 IRF3 IRF7 JUN LOC650832 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NFKB2 NFKBIA NFKBIB NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RELA RIPK1 RIPK2 RIPK3 RPS27A RPS27AP11 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A12 S100B SAA1 TAB1 TAB2 TAB3 TBK1 TICAM1 TLR3 TRAF6 UBA52 ZBP1 +REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis ACACA ACLY ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT9 DGAT1 DGAT2 ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 FASN GK GPAM GPAT2 GPD1 GPD1L HSD17B12 LCLAT1 LPCAT1 LPCAT4 LPIN1 LPIN2 LPIN3 SLC25A1 TECR +REACTOME_TRNA_AMINOACYLATION Genes involved in tRNA Aminoacylation AARS AARS2 AIMP1 AIMP2 CARS CARS2 DARS DARS2 EARS2 EEF1E1 EPRS FARS2 FARSA FARSB GARS HARS HARS2 IARS IARS2 KARS LARS LARS2 MARS MARS2 NARS NARS2 PARS2 PPA1 PPA2 QARS RARS RARS2 SARS SARS2 TARS TARS2 VARS VARS2 WARS WARS2 YARS YARS2 +REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism AADAT ACMSD AFMID CCBL1 CCBL2 HAAO IDO1 IDO2 KMO KYNU TDO2 +REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation ACTN2 AKAP9 CAMK2A CAMK2B CAMK2D GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL +REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response ACADVL ADD1 ARFGAP1 ASNS ATF3 ATF4 ATF4P3 ATF6 ATP6V0D1 C19orf10 CALR CCL2 CTDSP2 CUL7 CXXC1 DCP2 DCTN1 DDIT3 DDX11 DDX12P DIS3 DNAJB11 DNAJB9 DNAJC3 EDEM1 EIF2AK3 EIF2S1 ERN1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXTL3 FKBP14 GOSR2 GSK3A HDGF HERPUD1 HSP90B1 HSPA5 HYOU1 IGFBP1 IL8 KDELR3 KHSRP KLHDC3 LMNA LOC730136 MBTPS1 MBTPS2 NFYA NFYB PARN PDIA5 PDIA6 PPP2R5B PREB SEC31A SERP1 SHC1 SRPR SRPRB SSR1 SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 +REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA CDC45 GINS1 GINS2 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 +REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions FIGF FLT1 FLT4 KDR NRP1 NRP2 PDGFC VEGFA VEGFB VEGFC +REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G APOBEC3G CUL5 LOC652826 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RBX1 RPS27A RPS27AP11 TCEB1 TCEB1P3 TCEB2 UBA52 +REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis GTF2F1 GTF2F2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L +REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism AASDHPPT COASY FASN PANK1 PANK2 PANK3 PANK4 PPCDC PPCS SLC25A16 SLC5A6 +REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 +REACTOME_XENOBIOTICS Genes involved in Xenobiotics CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP3A4 CYP3A5 CYP3A7 LOC731992 +REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression CREBBP CTGF KAT2B MED1 NCOA1 NCOA2 NCOA3 NCOA6 NPPA PPARA PRIC285 RUNX2 RXRA SMARCD3 TBL1X TBL1XR1 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 TGS1 WWTR1 YAP1 +REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A7 SLC30A8 SLC39A1 SLC39A10 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 +SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2 BCR BLNK ELK1 FOS GRB2 HRAS JUN LYN MAP2K1 MAP3K1 MAPK1 MAPK3 MAPK8IP3 PAPPA RAC1 RPS6KA1 RPS6KA3 SHC1 SOS1 SYK VAV1 VAV2 VAV3 +SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. APAF1 BIRC2 BIRC3 CASP10 CASP3 CASP7 CASP8 CASP9 DFFA DFFB FAS FASLG GZMB PARP1 PRF1 SCAP SREBF1 SREBF2 XIAP +SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2 CASP3 CASP8 CFL1 CFLAR ENDOU FAS FASLG PDE6D +SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1 ARF3 CCND1 CDK2 CDK4 CDKN1A CDKN1B CDKN2A CFL1 E2F1 E2F2 MDM2 NXT1 PRB1 TP53 +SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC25A CDC25B CDK1 CDK7 CDKN1A CHEK1 NEK1 WEE1 +SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE CD44 CSF1 FCGR3A IL1B IL6R SELL SPN TGFB1 TGFB2 TNF TNFRSF1A TNFRSF1B TNFRSF8 TNFSF8 +SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1 BAD BAK1 BAX BCL10 BCL2 BCL2L1 BCL2L11 BID CASP8AP2 CASP9 CES1 +SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1 AKT2 AKT3 BPNT1 GRB2 ILK IPCEF1 MAPK1 MAPK3 PDPK1 PIK3CA PIK3CD PTEN PTK2B RBL2 SHC1 SOS1 +SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CDK2 CDK4 CDKN1B CDKN2A E2F1 E2F2 E2F4 PRB1 +SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1 AKT2 AKT3 CDKN1A ELK1 GRB2 HRAS MAP2K1 MAP2K2 NGF NGFR NTRK1 PIK3CA PIK3CD RHOA SHC1 SOS1 +SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1 AKT2 AKT3 BAD BCL2 BCR BLNK BTK CD19 CD22 CD81 CR2 CSK DAG1 FLOT1 FLOT2 GRB2 GSK3A GSK3B INPP5D ITPR1 ITPR2 ITPR3 LYN MAP4K1 MAPK1 MAPK3 NFATC1 NFATC2 NR0B2 PDPK1 PIK3CA PIK3CD PIK3R1 PLCG2 PPP1R13B PPP3CA PPP3CB PPP3CC PTPRC RAF1 SHC1 SOS1 SOS2 SYK VAV1 +SIG_CD40PATHWAYMAP Genes related to CD40 signaling CD40 DUSP1 GORASP1 IKBKG MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPKAPK5 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 PIK3CA PIK3CD PIK3R1 SYT1 TONSL TRAF2 TRAF3 TRAF5 TRAF6 +SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2 ACTR3 AKT1 AKT2 AKT3 ANGPTL2 ARHGAP1 ARHGAP4 ARHGEF11 BTK CDC42 CFL1 CFL2 GDI1 GDI2 INPPL1 ITPR1 ITPR2 ITPR3 LIMK1 MYLK MYLK2 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PDPK1 PIK3CA PIK3CD PIK3CG PIK3R1 PIK3R5 PITX2 PPP1R13B PTEN RACGAP1 RHO ROCK1 ROCK2 RPS4X SAG WASF1 WASL +SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1 AKT2 AKT3 BAD BCL2 GRB2 GSK3A GSK3B IL4R IRS1 IRS2 JAK1 JAK3 MAP4K1 MAPK1 MAPK3 PDPK1 PIK3CA PIK3CD PIK3R1 PPP1R13B RAF1 SHC1 SOCS1 SOS1 SOS2 STAT6 +SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1 AKT2 AKT3 BRD4 CAP1 CBL CDC42 CDKN2A CYTH3 F2RL2 FLOT1 FLOT2 FOXO1 GRB2 GSK3A GSK3B IGFBP1 INPPL1 IRS1 IRS2 IRS4 LNPEP MAPK1 MAPK3 PARD3 PARD6A PDPK1 PIK3CA PIK3CD PIK3R1 PPYR1 PTEN PTPN1 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SERPINB6 SFN SHC1 SLC2A4 SORBS1 SOS1 SOS2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1 AKT2 AKT3 BCR BTK CD19 CDKN2A CYTH3 DAPP1 FLOT1 FLOT2 FOXO3 GAB1 ITPR1 ITPR2 ITPR3 LYN NR0B2 NR4A3 PDPK1 PHF11 PIK3CA PIK3R5 PITX2 PLCG2 PPP1R13B PREX1 PTEN PTPRC RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SAG SYK VAV1 +SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1 AKT2 AKT3 BAD BCL2L1 CDC42 CDK2 CDKN1B CDKN2A CREB1 CREB3 CREB5 CYTH3 EBP ERBB4 F2RL2 FOXO3 GAB1 GADD45A GRB2 GSK3A GSK3B IFI27 IGF1 IGFBP1 INPPL1 IRS1 IRS2 IRS4 MET MTOR MYC NOLC1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PARD3 PARD6A PDPK1 PIK3CA PIK3CD PIK3R5 PPP1R13B PREX1 PTEN PTK2 PTPN1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SFN SHC1 SLC2A4 SOS1 SOS2 TSC1 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1 ACTG2 ACTR2 ACTR3 AKT1 ANGPTL2 CDC42 CFL1 CFL2 FLNA FLNC FSCN1 FSCN2 FSCN3 GDI1 GDI2 LIMK1 MYH2 MYLK MYLK2 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PFN1 PFN2 RHO ROCK1 ROCK2 RPS4X VASP WASF1 WASL +ST_ADRENERGIC Adrenergic Pathway AKT1 APC AR ASAH1 BRAF CAMP CCL13 CCL15 CCL16 CFB DAG1 EGFR GAST GNA11 GNA15 GNAI1 GNAQ ITPKA ITPKB ITPR1 ITPR2 ITPR3 KCNJ3 KCNJ5 KCNJ9 MAPK1 MAPK10 MAPK14 PHKA2 PIK3CA PIK3CD PIK3R1 PITX2 PTX3 RAF1 SRC +ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor AKT1 AKT2 AKT3 BAD BCR BLNK BTK CD19 CSK DAG1 EPHB2 GRB2 ITPKA ITPKB LYN MAP2K1 MAP2K2 MAPK1 NFAT5 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 PI3 PIK3CA PIK3CD PIK3R1 PLCG2 PPP1R13B PRDX1 RAF1 SERPINA4 SHC1 SOS1 SOS2 SYK TONSL VAV1 +ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. AKT1 ASAH1 ATF1 BRAF CAMP CREB1 CREB3 CREB5 CREBBP CRKL DAG1 EGR1 EGR2 EGR3 EGR4 ELK1 FRS2 GAST GNAQ JUN MAP1B MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 NTRK1 OPN1LW PIK3C2G PIK3CA PIK3CD PIK3R1 PTPN11 RASGRF2 RPS6KA3 SHC1 SRC TERF2IP TH TUBA1A +ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway ARAF ATF1 BAD BRAF CREB1 CREB3 CREB5 DUSP4 DUSP6 DUSP9 EEF2K EIF4E GRB2 KAT5 KLF6 MAP2K1 MAP2K2 MAP3K8 MAPK1 MAPK3 MKNK1 MKNK2 MOS NFKB1 RAP1A RPS6KA1 RPS6KA2 RPS6KA3 SHC1 SOS1 SOS2 TRAF3 +ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway AGFG1 ALG2 BAK1 BAX BFAR BTK CAD CASP10 CASP3 CASP8 CASP8AP2 CD7 CDK2AP1 CSNK1A1 DAXX DEDD DEDD2 DFFA DIABLO EGFR EPHB2 EZR FADD FAF1 FAIM2 FAS HSPB1 IL1A IL8 MAP2K4 MAP2K7 MAP3K1 MAP3K5 MAPK1 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MET NCS1 NFAT5 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 NR0B2 PARP1 PFN1 PFN2 PTPN13 RALBP1 RIPK1 ROCK1 SMPD1 TNFRSF6B TONSL TP53 TPX2 TRAF2 TUFM XIAP +ST_G_ALPHA_I_PATHWAY G alpha i Pathway AKT1 AKT2 AKT3 ASAH1 BRAF CFB DAG1 DRD2 EGFR EPHB2 GRB2 ITPKA ITPKB ITPR1 ITPR2 ITPR3 KCNJ3 KCNJ5 KCNJ9 MAPK1 PI3 PIK3CB PITX2 PLCB1 PLCB2 PLCB3 PLCB4 RAF1 RGS20 SHC1 SOS1 SOS2 SRC STAT3 TERF2IP +ST_G_ALPHA_S_PATHWAY G alpha s Pathway ASAH1 BFAR BRAF CAMP CFB CREB1 CREB3 CREB5 GAST MAPK1 RAF1 RAPGEF3 RASGRF2 SNX13 SRC TERF2IP +ST_GA12_PATHWAY G alpha 12 Pathway BTK CFB DLG4 EPHB2 F2 F2RL1 F2RL2 F2RL3 JUN MAP2K5 MAPK1 MAPK7 MAPK8 MYEF2 NR4A3 PLD1 PLD2 PLD3 PTK2 RAF1 RASAL1 SRC VAV1 +ST_GA13_PATHWAY G alpha 13 Pathway AKT1 AKT2 AKT3 ARHGEF11 BCL2 CDC42 CFB DLG4 GNA13 IKBKG LPA MAP2K4 MAP3K1 MAP3K5 MAPK8 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 PDPK1 PHKA2 PI3 PIK3CB PLD1 PLD2 PLD3 PRKD1 PTK2 RDX ROCK1 ROCK2 SERPINA4 SRF TBXA2R TONSL +ST_GAQ_PATHWAY G alpha q Pathway ADRBK1 AKT1 AKT2 AKT3 CFB DAG1 GNAQ IKBKG ITPKA ITPKB ITPR1 ITPR2 ITPR3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 PDPK1 PHKA2 PIK3CB PITX2 PLD1 PLD2 PLD3 TONSL VN1R1 +ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. APC ASAH1 CAMP CASP3 CERK CREB1 CREB3 CREB5 CXCL2 CXCR2 DAG1 EPHB2 FOS GNAQ ITPKA ITPKB JUN MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 PARP1 +ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway IL13 IL13RA1 IL13RA2 IL4R JAK1 JAK2 TYK2 +ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway ABL1 ACTN1 ACTR2 ACTR3 AKT1 AKT2 AKT3 ANGPTL2 ARHGAP26 ARHGAP35 ARHGEF6 ARHGEF7 ASAP1 BCAR1 BRAF CAV1 CDC42 CDKN2A CRK CSE1L DOCK1 EPHB2 FYN GRB2 GRB7 ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGB3BP MAP2K4 MAP2K7 MAP3K11 MAPK1 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MRAS MYLK MYLK2 P4HB PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PIK3CA PIK3CB PKLR PLCG1 PLCG2 PTEN PTK2 RAF1 RALA RASGRF2 RHO ROCK1 ROCK2 SHC1 SOS1 SOS2 SRC TERF2IP TLN1 TLN2 TNK2 VASP WAS ZYX +ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway. CISH ELP2 IFNG IFNGR1 JAK1 JAK2 PLA2G2A PTPRU REG1A STAT1 +ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway AKT1 AKT2 AKT3 CISH GRB2 IARS IL13RA1 IL2RG IL4 IL4R INPP5D JAK1 JAK2 JAK3 NR0B2 PI3 PIK3CA PPP1R13B RPS6KB1 SERPINA4 SHC1 SOS1 SOS2 SRC STAT6 TYK2 +ST_JAK_STAT_PATHWAY Jak-STAT Pathway CISH JAK1 JAK2 JAK3 PIAS1 PIAS3 PTPRU REG1A SOAT1 +ST_JNK_MAPK_PATHWAY JNK MAPK Pathway AKT1 ATF2 CDC42 DLD DUSP10 DUSP4 DUSP8 GAB1 GADD45A GCK IL1R1 JUN MAP2K4 MAP2K5 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K9 MAPK10 MAPK7 MAPK8 MAPK9 MYEF2 NFATC3 NR2C2 PAPPA SHC1 TAB1 TAB2 TP53 TRAF6 ZAK +ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. ADRB1 AKT1 APC ASAH1 CAMP CAV3 CFB DAG1 DLG4 EPHB2 GAST GNAI1 GNAQ ITPR1 ITPR2 ITPR3 KAT5 KCNJ3 KCNJ5 KCNJ9 MAPK1 PITX2 PLN PTX3 RAC1 RHO RYR1 +ST_P38_MAPK_PATHWAY p38 MAPK Pathway AKT1 ATF1 CDC42 CREB1 CREB3 CREB5 DUSP1 DUSP10 EEF2K EIF4E ELK1 GADD45A HSPB1 IL1R1 MAP2K3 MAP2K4 MAP2K6 MAP3K10 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK5 MKNK1 MKNK2 MYEF2 NFKB1 NR2C2 SRF TAB1 TAB2 TRAF6 +ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway ASAH1 CAMP DAG1 GAST GNAQ ITPKA ITPKB +ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway A1BG AKT1 AKT2 AKT3 BAD BTK CD55 CDKN2A CYTH3 DAPP1 EXOSC1 FOXO1 GRB2 GSK3A GSK3B IARS IGFBP1 INPP5D NR4A3 PDPK1 PIK3CA PPP1R13B PTEN RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SFN SHC1 SOS1 SOS2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ +ST_STAT3_PATHWAY STAT3 Pathway CISH IL6 IL6R JAK1 JAK2 JAK3 PIAS3 PTPRU REG1A SRC STAT3 +ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction CBL CD28 CD3D CSK CTLA4 DAG1 DTYMK EPHB2 FBXW7 GRAP2 GRB2 ITK ITPKA ITPKB LAT LCK LCP2 MAPK1 NCK1 NFAT5 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PLCG1 PRDX1 PTPRC RAF1 RASGRP1 RASGRP2 RASGRP3 RASGRP4 SOS1 SOS2 TONSL VAV1 ZAP70 +ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway. AGFG1 BAG4 BIRC2 BIRC3 CASP3 CASP8 CFLAR FADD IKBKG JUN MAP2K4 MAP3K3 MAP3K7 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 NR2C2 RALBP1 RIPK1 TNF TNFAIP3 TNFRSF1A TNFRSF1B TONSL TRADD TRAF2 +ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway IFNAR1 IFNB1 IRF9 JAK1 PTPRU REG1A STAT1 STAT2 TYK2 +ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway AKT1 AKT2 AKT3 ANKRD6 APC AXIN1 AXIN2 CBY1 CER1 CSNK1A1 CTNNB1 CXXC4 DACT1 DKK1 DKK2 DKK3 DKK4 DVL1 FRAT1 FSTL1 GSK3A GSK3B LRP1 MVP NKD1 NKD2 PIN1 PSEN1 PTPRA RPSA SENP2 SFRP1 TSHB WIF1 +ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling. CAMK2A CAMK2B CAMK2D CAMK2G CFB DAG1 ITPKA ITPKB ITPR1 ITPR2 ITPR3 NFAT5 PDE6A PDE6B PDE6C PDE6D PDE6G PDE6H SLC6A13 TF +WNT_SIGNALING Genes related to Wnt-mediated signal transduction ACTB AES APC AXIN1 B2M BCL9 BTRC CCND1 CCND2 CCND3 CSNK1A1 CSNK1D CSNK1G1 CSNK2A1 CTBP1 CTBP2 CTNNB1 CTNNBIP1 CXXC4 DAAM1 DIXDC1 DKK1 DVL1 DVL2 EP300 FBXW11 FBXW2 FBXW4 FGF4 FOSL1 FOXN1 FRAT1 FRZB FSHB FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 GAPDH GSK3A GSK3B HPRT1 JUN KREMEN1 LEF1 LRP5 LRP6 MYC NKD1 NLK PITX2 PORCN PPP2CA PPP2R1A PYGO1 RHOU RPL13A SENP2 SFRP1 SFRP4 SLC9A3R1 SOX17 T TCF7 TCF7L1 TLE1 TLE2 WIF1 WISP1 WNT1 WNT10A WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT9A