Time series of epileptic seizures in a 8yo male on a cannabidiol trial

Creators

Barry, Dwight

Description

Time series of epileptic seizures in a 8yo male with idiopathic catastrophic epilepsy (probably of mitochondrial origin) in a cannabidiol (CBD) trial.

The data are of observed seizures during each day by the patient's parents and caregivers and thus are not exact values for total daily seizure activity; the values in this dataset are best considered a lower bound. However, observation effort was essentially constant over the time series, so the data likely reflect overall trends even though precise daily seizure counts are not available.

The time series includes a 21-day baseline period and a 36-day trial period. The CBD was administered via g-tube in an olive oil base. Dosage was approximately 7.5 mg/kg/day for two weeks, and approximately 8 mg/kg/day for three weeks.

Each 1ml of oil contained 10.00mg of total CBD and 0.42mg of total THC, for a CBD:THC ratio of approximately 20:1 (analysis by HPLC).

Data Dictionary:
* Date: YYYY-MM-DD
* Tonic: tonic seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-seizures)
* Tonic-Clonic: tonic-clonic (aka "grand mal") seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-clonic-seizures)
* Spasms: myoclonic seizure count (http://www.epilepsy.com/learn/types-seizures/myoclonic-seizures)
* Total: total number of seizures (sum of above)
* Notes: notes by parents