Summary Statistics: Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

Creators

• Mitchell, Jonathan

Contributors

Researchers:

• Camacho, Niedzica
• Shea, Patrick
• Stopsack, Konrad
• Joseph, Vijai
• Burren, Oliver
• Dhindsa, Ryan
• Nag, Abhishek
• Berchuck, Jacob
• O'Neill, Amanda
• Abbasi, Ali
• Zoghbi, Anthony
• Alegre-Díaz, Jesus
• Kuri-Morales, Pablo
• Berumen, Jaime
• Tapia-Conyer, Roberto
• Emberson, Jonathan
• Torres, Jason
• Collins, Rory
• Wang, Quanli
• Goldstein, David
• Matakidou, Athena
• Haefliger, Carolina
• Anderson-Dring, Lauren
• March, Ruth
• Jobanputra, Vaidehi
• Dougherty, Brian
• Carss, Keren
• Petrovski, Slavé
• Kantoff, Philip
• Offit, Kenneth
• Mucci, Lorelei
• Pomerantz, Mark
• Fabre, Margarete

Description

Exome-wide gene and single variant level summary statistics associated with the Nature Communications article "Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases".

Gene Level Association Files

• gene_level_prostate_cancer_risk.txt: Gene-level summary statistics for association with prostate cancer risk (case vs controls)
• gene_level_prostate_cancer_severity.txt: Gene-level summary statistics for association with prostate cancer severity (aggressive prostate cancer vs non-aggressive prostate cancer)
• gene_level_prostate_cancer_agg_ctrl.txt: Gene-level summary statistics for association of aggressive prostate cancer vs controls

Columns

• Gene Name
• Gene ENSG - Ensembl gene ID
• CA_model - collapsing analysis qualifying variant model (as in Supplementary Data 1 of article)
• CMH_P - meta analysis P-value
• CMH_OR - meta analysis odds ratio
• CMH_OR_LCI - meta analysis odds ratio lower confidence interval
• CMH_OR_UCI - meta analysis odds ratio upper confidence interval
• Total Qual Cases - number of cases carrying a qualifying variant
• Total Unqual Cases - number of cases not carrying a qualifying variant
• Total Qual Ctrls - number of controls carrying a qualifying variant
• Total Unqual Ctrls - number of controls not carrying a qualifying variant

Single Variant Level Association File

• single_variant_prostate_cancer_risk.txt: Single variant level summary statistics for association with prostate cancer risk (case vs controls)

Columns

• chr - chromosome
• pos - genomic position
• effect_allele
• other_allele
• P - meta analysis P-value
• direction - direction of effect in individual cohorts (100KGP, MCPS, UKB_SAS, UKB_AFR, UKB_EUR, FinnGen)