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<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE159610"><a href="/geo/query/acc.cgi?acc=GSE159610" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE159610</a></strong></td>
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<td></td>
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<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE159610[Accession]">Query DataSets for GSE159610</a></td>
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</tr></tbody></table></td></tr>
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<tr valign="top"><td>Status</td>
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<td>Public on Oct 22, 2020</td>
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</tr>
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<tr valign="top"><td nowrap="">Title</td>
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<td style="text-align: justify">Whole blood transcriptomes of patients receiving digital subtraction angiography</td>
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<tr valign="top"><td nowrap="">Organism</td>
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<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td>
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<tr valign="top"><td nowrap="">Experiment type</td>
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<td>Expression profiling by high throughput sequencing<br></td>
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<tr valign="top"><td nowrap="">Summary</td>
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<td style="text-align: justify">Circulating whole blood transcriptomes can detect the presence of unruptured cerebral aneurysms. Pending additional testing in larger cohorts, this could serve as a foundation to develop a simple blood-based test to facilitate screening and early detection of cerebral aneurysms.<br></td>
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<tr valign="top"><td nowrap="">&nbsp;</td>
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<td></td>
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<tr valign="top"><td nowrap="">Overall design</td>
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<td style="text-align: justify">We subjected RNA from peripheral whole blood of 47 patients undergoing cerebral digital subtraction angiogrpahy to next-generation RNA sequencing.<br></td>
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<tr valign="top"><td nowrap="">&nbsp;</td>
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<td></td>
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<tr valign="top"><td>Contributor(s)</td>
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<td><a href="/pubmed/?term=Poppenberg KE[Author]">Poppenberg KE</a>, <a href="/pubmed/?term=Tutino VM[Author]">Tutino VM</a></td>
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<tr valign="top"><td nowrap="">Citation(s)</td>
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<td><span class="pubmed_id" id="33156839,34441376"><!--?xml version="1.0" encoding="UTF-8"?-->
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<div class="PubmedCitation"><ul><li><span class="authors">Poppenberg KE, Li L, Waqas M, Paliwal N et al. </span><span class="title">Whole blood transcriptome biomarkers of unruptured intracranial aneurysm. </span><span class="source">PLoS One</span> 2020;15(11):e0241838. PMID:&nbsp;<a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/33156839">33156839</a></li><li><span class="authors">Tutino VM, Lu Y, Ishii D, Poppenberg KE et al. </span><span class="title">Aberrant Whole Blood Gene Expression in the Lumen of Human Intracranial Aneurysms. </span><span class="source">Diagnostics (Basel)</span> 2021 Aug 10;11(8). PMID:&nbsp;<a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/34441376">34441376</a></li></ul></div>
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</span></td>
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<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>
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<td>Oct 19, 2020</td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>
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<td>Aug 31, 2021</td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>
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<td>Kerry E Poppenberg</td>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>
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<td style="text-align: justify">University at Buffalo<br></td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>
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<td style="text-align: justify">875 Ellicott St<br></td>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>
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<td style="text-align: justify">BUFFALO</td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">State/province</td>
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<td style="text-align: justify">NY</td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>
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<td style="text-align: justify">14203</td>
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</tr>
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>
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<td style="text-align: justify">USA</td>
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</tr>
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<tr valign="top"><td nowrap="">&nbsp;</td>
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<td></td>
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<tr valign="top"><td>Platforms (1)</td>
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<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL16791" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL16791</a></td>
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<td valign="top">Illumina HiSeq 2500 (Homo sapiens)</td>
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</tr></tbody></table></td>
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</tbody></table>