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+This DATSETNAMEreadme.txt file was generated on 2022-05-18 by Li Liu
+
+GENERAL INFORMATION
+
+1. Title of Dataset: Datasets used in the manuscript "Early detection of cerebrovascular pathology and protective antiviral immunity by MRI"
+
+2. Author Information
+	A. Principal Investigator Contact Information
+		Name: Li Liu
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA
+		Email: li.liu3@nih.gov
+
+		Name: Alan P. Koretsky
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA
+		Email: koretskya@ninds.nih.gov
+
+	B. Associate or Co-investigator Contact Information
+		Name: Stephen Dodd
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: doddst@ninds.nih.gov
+
+		Name: Ryan D. Hunt
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: Ryan.Hunt@uvm.edu
+
+		Name: Nikorn Pothayee
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: nikorn.pothayee@nih.gov
+
+		Name: Tatjana Atanasijevic
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: tatjana.atanasijevic@nih.gov
+
+		Name: Nadia Bouraoud
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: Nadia.Bouraoud@nih.gov
+
+		Name: Dragan Maric
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: maricd@ninds.nih.gov
+
+		Name: E. Ashley Moseman
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: ashley.moseman@duke.edu
+
+		Name: Selamawit Gossa
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: selamawit.gossa@nih.gov
+
+		Name: Dorian B. McGavern
+		Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
+		Address: 10 Center Drive, Building 10, Bethesda, MD 20892, USA 
+		Email: mcgavernd@ninds.nih.gov
+
+	C. Alternate Contact Information
+		Name: E. Ashley Moseman
+		Institution: Duke University School of Medicine
+		Address: Durham, NC 27710, USA 
+		Email: ashley.moseman@duke.edu
+
+3. Date of data collection: From 2017-12-01 to 2022-03-02
+
+4. Geographic location of data collection: Bethesda, MD, USA
+
+5. Information about funding sources that supported the collection of the data: 
+	The Intramural Program of the National Institute of Neurological Disorders and Stroke (1ZIANS003047-15) for Alan P Koretsky
+	The Intramural Program of the National Institute of Neurological Disorders and Stroke (1ZIANS003112-13) for Dorian B McGavern
+
+DATA & FILE OVERVIEW
+File List: 
+	Method of Data Collection.docx - Description of experimental methodology that used in this study.
+	Source Data Fig 1.xlsx - Quantification of volume of hypointensity in the turbinates and numbers of hypointensity spots in the OB on day 4, 6, and 11. 
+	Source Data Fig 2.xlsx - Quantification of numbers of hypointensity spots in the brain (not including OB) on day 4, 6, and 11.
+	Source Data Fig 3.xlsx - Quantification of IHC staining showed increased expression of endothelial VCAM-1 and ICAM-1 in the OB on day 6 of infection. Quantification of the volume of bleeding in the turbinates and the numbers of hypointensity spots in the OB and brain on day 6, in the isotype control group and anti-LFA-1/VLA-4 antibodies treated group.
+	Source Data Fig 5.xlsx - Quantification of volume of bleeding in the turbinates and numbers of hypointensity spots in the OB and brain without or with T cells early and late transfer 
+	Source Data Fig 6.xlsx - Quantification of IHC study verified that antiviral CD8 T cells reduced VSV-induced brain bleeding.
+	Source Data Fig 8.xlsx - Quantification of IHC study showing the activation of vessel endothelium cells and microglia were found at the ONL/GL and MCL/GCL on day 1. 
+	Source Data Figure 3-figure supplement 1.xlsx - Quantification of IHC staining showed increased expression of endothelial VCAM-1 and ICAM-1 in the OB and thalamus on day 6 of infection.
+	Source Data Figure 6-figure supplement 1.xlsx - Quantification of bleeding volume in turbinates, and number of hypointensity spots in OB and brain without or with T cell transfer (5 x 105 T cells, and 3 x 106 T cells) on day 11.
+	Source Data Figure 8-figure supplement 2.xlsx - Quantification of the number of hypointensity spots in OB and brain on day 6 and 11, upon transfer of unlabeled CD8 T cells or MPIO-labeled CD8 T cells.
+
+METHODOLOGICAL INFORMATION
+	Method of Data Collection.docx
+