|
| Status |
Public on Oct 31, 2022 |
| Title |
Gene expression profile of macrophages in aneurysm lesions at the growth phase. |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Recent experimental studies have defined intracranial aneurysms as a macrophage-mediated chronic inflammatory disease affecting intracranial arteries. We used single cell RNA sequencing (scRNA-seq) to analyze the population of macrophages in aneurysm lesions at the growth phase.
|
| |
|
| Overall design |
The previously-established aneurysm model of rats was used. Macrophages were labeled with the fluorescent protein and isolated by a laser-microdissection method and analyzed using scRNAseq.
|
| |
|
| Contributor(s) |
Tomohiro A |
| Citation(s) |
- Okada A, Koseki H, Ono I, Kayahara T et al. Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase. J Stroke Cerebrovasc Dis 2022 Dec;31(12):106848. PMID: 36323172
|
| |
| Submission date |
Oct 24, 2022 |
| Last update date |
Jan 30, 2023 |
| Contact name |
Akihiro Okada |
| E-mail(s) |
aokada6@kuhp.kyoto-u.ac.jp
|
| Organization name |
National Cerebral and Cardiovascular Center
|
| Department |
Department of Molecular Pharmacology
|
| Street address |
6-1 Kishibe-Shinmachi
|
| City |
Suita City |
| State/province |
Osaka |
| ZIP/Postal code |
564-8565 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
|
