<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE216393"><a href="/geo/query/acc.cgi?acc=GSE216393" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE216393</a></strong></td>

<td></td>

<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE216393[Accession]">Query DataSets for GSE216393</a></td>

</tr></tbody></table></td></tr>

<tr valign="top"><td>Status</td>

<td>Public on Oct 31, 2022</td>

</tr>

<tr valign="top"><td nowrap="">Title</td>

<td style="text-align: justify">Gene expression profile of macrophages in aneurysm lesions at the growth phase.</td>

</tr>

<tr valign="top"><td nowrap="">Organism</td>

<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=10116" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Rattus norvegicus</a></td>

</tr>

<tr valign="top"><td nowrap="">Experiment type</td>

<td>Expression profiling by high throughput sequencing<br></td>

</tr>

<tr valign="top"><td nowrap="">Summary</td>

<td style="text-align: justify">Recent experimental studies have defined intracranial aneurysms as a macrophage-mediated chronic inflammatory disease affecting intracranial arteries. We used single cell RNA sequencing (scRNA-seq) to analyze the population of macrophages in aneurysm lesions at the growth phase.<br></td>

</tr>

<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

</tr>

<tr valign="top"><td nowrap="">Overall design</td>

<td style="text-align: justify">The previously-established aneurysm model of rats was used. Macrophages were labeled with the fluorescent protein and isolated by a laser-microdissection method and analyzed using scRNAseq.<br></td>

</tr>

<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

</tr>

<tr valign="top"><td>Contributor(s)</td>

<td><a href="/pubmed/?term=Tomohiro A[Author]">Tomohiro A</a></td>

</tr>

<tr valign="top"><td nowrap="">Citation(s)</td>

<td><span class="pubmed_id" id="36323172"><!--?xml version="1.0" encoding="UTF-8"?-->

<div class="PubmedCitation"><ul><li><span class="authors">Okada A, Koseki H, Ono I, Kayahara T et al. </span><span class="title">Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase. </span><span class="source">J Stroke Cerebrovasc Dis</span> 2022 Dec;31(12):106848. PMID:&nbsp;<a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/36323172">36323172</a></li></ul></div>

</span></td>

</tr>

<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr>

<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>

<td>Oct 24, 2022</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>

<td>Jan 30, 2023</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>

<td>Akihiro Okada</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td>

<td><a href="mailto:aokada6@kuhp.kyoto-u.ac.jp">aokada6@kuhp.kyoto-u.ac.jp</a><br></td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>

<td style="text-align: justify">National Cerebral and Cardiovascular Center<br></td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Department</td>

<td style="text-align: justify">Department of Molecular Pharmacology<br></td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>

<td style="text-align: justify">6-1 Kishibe-Shinmachi<br></td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>

<td style="text-align: justify">Suita City</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">State/province</td>

<td style="text-align: justify">Osaka</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>

<td style="text-align: justify">564-8565</td>

</tr>

<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>

<td style="text-align: justify">Japan</td>

</tr>

<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

</tr>

<tr valign="top"><td>Platforms (1)</td>

<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL20084" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL20084</a></td>

<td valign="top">Illumina NextSeq 500 (Rattus norvegicus)</td>

</tr></tbody></table></td>

</tr>

</tbody></table>