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<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE272079"><a href="/geo/query/acc.cgi?acc=GSE272079" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE272079</a></strong></td> |
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<td></td> |
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<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE272079[Accession]">Query DataSets for GSE272079</a></td> |
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</tr></tbody></table></td></tr> |
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<tr valign="top"><td>Status</td> |
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<td>Public on Oct 25, 2024</td> |
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</tr> |
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<tr valign="top"><td nowrap="">Title</td> |
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<td style="text-align: justify">miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke</td> |
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</tr> |
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<tr valign="top"><td nowrap="">Organism</td> |
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<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td> |
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</tr> |
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<tr valign="top"><td nowrap="">Experiment type</td> |
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<td>Non-coding RNA profiling by high throughput sequencing<br></td> |
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<tr valign="top"><td nowrap="">Summary</td> |
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<td style="text-align: justify">Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, and immune regulation, and monitor disease development. We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). Clean data (15.48 Gb) were obtained for lncRNAs and mRNAs. Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified. Finally, gene expression profiles and differentially expressed genes were analysed in 20 samples. In the plasma samples, 74 miRNAs, 12 lncRNAs, and 693 mRNAs were identified. Tumour-derived tissue samples contained 61 miRNAs, 67 lncRNAs, and 433 mRNAs. This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS versus CM without stroke.<br></td> |
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</tr> |
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<tr valign="top"><td nowrap=""> </td> |
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<td></td> |
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</tr> |
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<tr valign="top"><td nowrap="">Overall design</td> |
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<td style="text-align: justify">We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).<br></td> |
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</tr> |
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<tr valign="top"><td nowrap=""> </td> |
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<td></td> |
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</tr> |
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<tr valign="top"><td>Contributor(s)</td> |
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<td><a href="/pubmed/?term=Ma L[Author]">Ma L</a>, <a href="/pubmed/?term=Liu G[Author]">Liu G</a></td> |
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</tr> |
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<tr valign="top"><td nowrap="">Citation(s)</td> |
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<td><span class="pubmed_id" id="39820519"><!--?xml version="1.0" encoding="UTF-8"?--> |
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<div class="PubmedCitation"><ul><li><span class="authors">Ma L, Liu YH, Liu C, Wang SQ et al. </span><span class="title">lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke. </span><span class="source">Sci Data</span> 2025 Jan 16;12(1):91. PMID: <a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/39820519">39820519</a></li></ul></div> |
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</span></td> |
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</tr> |
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<tr valign="top"><td nowrap="">BioProject</td> |
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<td><span class="gp_id" id="PRJNA1111286"><ul><li><a href="/bioproject/PRJNA1111286">PRJNA1111286</a> miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke</li></ul></span></td> |
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</tr> |
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<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr> |
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<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td> |
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<td>Jul 11, 2024</td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td> |
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<td>Feb 14, 2025</td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td> |
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<td>Lin Ma</td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td> |
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<td><a href="mailto:linma0720@aliyun.com">linma0720@aliyun.com</a><br></td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td> |
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<td style="text-align: justify">Beijing Anzhen Hospital<br></td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td> |
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<td style="text-align: justify">No. 2 Anzhen Rd District, Beijing, China<br></td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td> |
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<td style="text-align: justify">Beijing</td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td> |
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<td style="text-align: justify">100029</td> |
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</tr> |
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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td> |
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<td style="text-align: justify">China</td> |
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</tr> |
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<tr valign="top"><td nowrap=""> </td> |
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<td></td> |
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</tr> |
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<tr valign="top"><td>Platforms (1)</td> |
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<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL24676" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL24676</a></td> |
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<td valign="top">Illumina NovaSeq 6000 (Homo sapiens)</td> |
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</tr></tbody></table></td> |
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</tr> |
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<tr valign="top"><td>Samples (20)<div id="L532478163divshown" name="L532478163divshown" style="display: none"><a href="javascript:HandleVisibilityChangeL532478163()"><img alt="Less..." border="0" src="/geo/img/minus_close.gif"> Less...</a> </div> |
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<div id="L532478163divhidden" name="L532478163divhidden" style="display: block"><a href="javascript:HandleVisibilityChangeL532478163()"><img alt="More..." border="0" src="/geo/img/plus_small.gif"> More...</a></div> |
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</td> |
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<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392622" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392622</a></td> |
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<td valign="top">A1, mi, non-IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392623" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392623</a></td> |
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<td valign="top">A3, mi, non-IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392624" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392624</a></td> |
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<td valign="top">A4, mi, non-IS</td> |
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</tr> |
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</tbody></table> |
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<script language="Javascript" type="text/javascript"> |
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<!-- |
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function HandleVisibilityChangeL532478163(){if(document.getElementById("L532478163div").style.display == "block"){document.getElementById("L532478163div").style.display = "none";document.getElementById("L532478163divhidden").style.display = "block";document.getElementById("L532478163divshown").style.display = "none";}else{document.getElementById("L532478163div").style.display = "block";document.getElementById("L532478163divhidden").style.display = "none";document.getElementById("L532478163divshown").style.display = "block";}} |
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--> |
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</script> |
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<div id="L532478163div" name="L532478163div" style="display: none"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392625" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392625</a></td> |
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<td valign="top">A5, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392626" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392626</a></td> |
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<td valign="top">A6, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392627" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392627</a></td> |
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<td valign="top">A7, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392628" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392628</a></td> |
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<td valign="top">A8, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392629" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392629</a></td> |
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<td valign="top">A9, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392630" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392630</a></td> |
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<td valign="top">A10, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392631" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392631</a></td> |
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<td valign="top">A11, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392632" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392632</a></td> |
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<td valign="top">B1, mi, non-IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392633" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392633</a></td> |
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<td valign="top">B3, mi, non-IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392634" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392634</a></td> |
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<td valign="top">B4, mi, non-IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392635" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392635</a></td> |
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<td valign="top">B5, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392636" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392636</a></td> |
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<td valign="top">B6, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392637" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392637</a></td> |
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<td valign="top">B7, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392638" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392638</a></td> |
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<td valign="top">B8, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392639" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392639</a></td> |
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<td valign="top">B9, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392640" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392640</a></td> |
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<td valign="top">B10, mi, IS</td> |
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</tr> |
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<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8392641" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8392641</a></td> |
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<td valign="top">B11, mi, IS</td> |
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</tr> |
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</tbody></table></div> |
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</td> |
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</tr> |
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</tbody></table> |
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<br><span id="gdv"></span><table cellspacing="3" width="600"><tbody><tr bgcolor="#eeeeee"><td><strong>Download family</strong></td> |
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<td><strong>Format</strong></td> |
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</tr> |
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<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/soft/" target="_blank">SOFT formatted family file(s)</a></td> |
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<td>SOFT<a href="javascript:RPopUpWindow_Set(geoaxema_famsoft,260,120,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td> |
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</tr> |
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<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/miniml/" target="_blank">MINiML formatted family file(s)</a></td> |
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<td>MINiML<a href="javascript:RPopUpWindow_Set(geoaxema_famminiml,260,120,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td> |
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</tr> |
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<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/matrix/" target="_blank">Series Matrix File(s)</a></td> |
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<td>TXT<a href="javascript:RPopUpWindow_Set(geoaxema_fammatrix,260,210,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td> |
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</tr> |
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</tbody></table> |
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<br><table cellpadding="2" cellspacing="2" width="600"><tbody><tr bgcolor="#eeeeee" valign="top"><td align="middle" bgcolor="#CCCCCC"><strong>Supplementary file</strong></td> |
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<td align="middle" bgcolor="#CCCCCC"><strong>Size</strong></td> |
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<td align="middle" bgcolor="#CCCCCC"><strong>Download</strong></td> |
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<td align="middle" bgcolor="#CCCCCC"><strong>File type/resource</strong></td> |
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</tr> |
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<tr valign="top"><td bgcolor="#DEEBDC">GSE272079_All_miRNA_UMI.TPM.list.txt.gz</td> |
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<td bgcolor="#DEEBDC" title="45227">44.2 Kb</td> |
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<td bgcolor="#DEEBDC"><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/suppl/GSE272079%5FAll%5FmiRNA%5FUMI%2ETPM%2Elist%2Etxt%2Egz">(ftp)</a><a href="/geo/download/?acc=GSE272079&format=file&file=GSE272079%5FAll%5FmiRNA%5FUMI%2ETPM%2Elist%2Etxt%2Egz">(http)</a></td> |
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<td bgcolor="#DEEBDC">TXT</td> |
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</tr> |
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<tr valign="top"><td bgcolor="#EEEEEE">GSE272079_differential_analysis_table_of_miRNA_in_plasma_exosomes.DEG_final.txt.gz</td> |
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<td bgcolor="#EEEEEE" title="4333">4.2 Kb</td> |
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<td bgcolor="#EEEEEE"><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/suppl/GSE272079%5Fdifferential%5Fanalysis%5Ftable%5Fof%5FmiRNA%5Fin%5Fplasma%5Fexosomes%2EDEG%5Ffinal%2Etxt%2Egz">(ftp)</a><a href="/geo/download/?acc=GSE272079&format=file&file=GSE272079%5Fdifferential%5Fanalysis%5Ftable%5Fof%5FmiRNA%5Fin%5Fplasma%5Fexosomes%2EDEG%5Ffinal%2Etxt%2Egz">(http)</a></td> |
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<td bgcolor="#EEEEEE">TXT</td> |
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</tr> |
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<tr valign="top"><td bgcolor="#DEEBDC">GSE272079_differential_analysis_table_of_miRNA_in_tumor_exosomes.DEG_final.txt.gz</td> |
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<td bgcolor="#DEEBDC" title="3940">3.8 Kb</td> |
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<td bgcolor="#DEEBDC"><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272079/suppl/GSE272079%5Fdifferential%5Fanalysis%5Ftable%5Fof%5FmiRNA%5Fin%5Ftumor%5Fexosomes%2EDEG%5Ffinal%2Etxt%2Egz">(ftp)</a><a href="/geo/download/?acc=GSE272079&format=file&file=GSE272079%5Fdifferential%5Fanalysis%5Ftable%5Fof%5FmiRNA%5Fin%5Ftumor%5Fexosomes%2EDEG%5Ffinal%2Etxt%2Egz">(http)</a></td> |
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<td bgcolor="#DEEBDC">TXT</td> |
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</tr> |
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<tr><td><a href="/Traces/study/?acc=PRJNA1111286">SRA Run Selector</a><a href="javascript:RPopUpWindow_Set(geoaxema_srarun,260,120,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td></tr> |
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<tr><td class="message">Raw data are available in SRA</td></tr> |
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</tbody></table> |
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<span id="customDlArea"></span><br></td></tr></tbody></table> |