--- a +++ b/README.MD @@ -0,0 +1,31 @@ +# Title of Dataset: Radiation therapy induces innate immune responses in patients treated for prostate cancers +--- + +Following radiation therapy, proteomic and metabolomic profiles reveal a robust immune activation that correlate with prostate cancer remission + + +## Description of the Data and file structure + +Protein quantities were recorded as relative fluorescent units (RFU), which can be converted to concentrations with standard curves. The samples were batch processed using the SOMAscan Version 3 assays according to the manufacturer’s instructions. This assay is commercially available and has been used to investigate other disease systems including lung cancer. + +Mass spectrometry was performed on a performed on a Q-TOF instrument (Xevo G2 QTOF, Waters Corp, USA) operating in either negative (ESI-) or positive (ESI+) electrospray ionization mode with a capillary voltage of 3200 V in positive mode and 2800 V in negative mode, and a sampling cone voltage of 30 V in both positive and negative modes. + +- somalogicfulldata.xlsx contains the proteomics data +- Normalized_NEG_MODE_AKC.xlsx contains the metabolomics negative mode data +- Normalized_POS_MODE_AKC.xlsx contains the metabolomics positive mode data + +Sample collection times are defined using colors from top left to right: + +- Green represenets for the sample collected pre-treatment. +- Yellow represents for the sample collected 24 hours post treatment. +- Blue represents for the sample collected 1 month post treatment. +- Pink represents for the sample collected 3 months post treatment. +- Brown represents for the sample collected 6 months post treatment. +- Orange represents for the sample collected after 6 months post treatment. + +## Sharing/access Information + +Links to other publicly accessible locations of the data: + +Was data derived from another source? no +If yes, list source(s): \ No newline at end of file