ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count	link
hsa05205	Proteoglycans in cancer	138/3197	204/8019	4.40601419206904e-16	1.4231425840383e-13	8.30185831979324e-14	TP53/AKT3/MAPK14/MAPK3/CCND1/TGFB2/WNT9B/PRKACB/RPS6/KRAS/FZD5/VEGFA/EGFR/PTCH1/GRB2/MMP2/CTNNB1/ESR1/MTOR/MAPK1/SOS1/AKT1/WNT5A/IGF2/SDC1/ITGA5/FZD4/MAP2K1/SRC/WNT7A/FLNA/ITGB1/IGF1/HOXD10/ITGA2/MMP9/FRS2/WNT4/CASP3/PTPN11/TGFB1/WNT7B/STAT3/HIF1A/HRAS/MDM2/CDKN1A/ACTB/TFAP4/PTPN6/MYC/RDX/CAMK2A/RPS6KB1/PPP1R12B/PPP1R12A/PPP1CB/TNF/SMAD2/TWIST1/FGFR1/FZD8/EZR/RAC1/CDC42/NRAS/ROCK1/CAV2/PLCE1/PPP1CC/BRAF/WNT16/IGF1R/ERBB2/KDR/ROCK2/PAK1/ERBB3/FAS/THBS1/TLR4/RRAS/IQGAP1/ERBB4/FN1/FGF2/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/TIAM1/CD44/HBEGF/TIMP3/PDCD4/FZD7/HGF/PDPK1/AKT2/PRKCB/RHOA/PIK3CA/CAMK2G/MRAS/ACTG1/RRAS2/PXN/COL1A1/GPC3/SDC4/HPSE/NUDT16L1/SOS2/PLCG1/PIK3R1/ITGB3/MSN/ELK1/NANOG/COL1A2/TLR2/WNT8B/FZD9/FZD1/VAV2/VAV3/DROSHA/WNT10A/ITPR2/ITPR1/EIF4B/FZD6/FZD2/PLCG2/PLAUR/PPP1R12C/ANK1	138	http://www.kegg.jp/kegg-bin/show_pathway?hsa05205/TP53/AKT3/MAPK14/MAPK3/CCND1/TGFB2/WNT9B/PRKACB/RPS6/KRAS/FZD5/VEGFA/EGFR/PTCH1/GRB2/MMP2/CTNNB1/ESR1/MTOR/MAPK1/SOS1/AKT1/WNT5A/IGF2/SDC1/ITGA5/FZD4/MAP2K1/SRC/WNT7A/FLNA/ITGB1/IGF1/HOXD10/ITGA2/MMP9/FRS2/WNT4/CASP3/PTPN11/TGFB1/WNT7B/STAT3/HIF1A/HRAS/MDM2/CDKN1A/ACTB/TFAP4/PTPN6/MYC/RDX/CAMK2A/RPS6KB1/PPP1R12B/PPP1R12A/PPP1CB/TNF/SMAD2/TWIST1/FGFR1/FZD8/EZR/RAC1/CDC42/NRAS/ROCK1/CAV2/PLCE1/PPP1CC/BRAF/WNT16/IGF1R/ERBB2/KDR/ROCK2/PAK1/ERBB3/FAS/THBS1/TLR4/RRAS/IQGAP1/ERBB4/FN1/FGF2/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/TIAM1/CD44/HBEGF/TIMP3/PDCD4/FZD7/HGF/PDPK1/AKT2/PRKCB/RHOA/PIK3CA/CAMK2G/MRAS/ACTG1/RRAS2/PXN/COL1A1/GPC3/SDC4/HPSE/NUDT16L1/SOS2/PLCG1/PIK3R1/ITGB3/MSN/ELK1/NANOG/COL1A2/TLR2/WNT8B/FZD9/FZD1/VAV2/VAV3/DROSHA/WNT10A/ITPR2/ITPR1/EIF4B/FZD6/FZD2/PLCG2/PLAUR/PPP1R12C/ANK1
hsa05210	Colorectal cancer	66/3197	86/8019	2.92460329979346e-12	4.72323432916643e-10	2.75528416138436e-10	TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/EGFR/LEF1/BCL2/GRB2/CTNNB1/MTOR/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/MLH1/MSH2/MAP2K1/BAX/BCL2L11/EREG/MSH6/MSH3/CASP3/TGFB1/FOS/APC/HRAS/GADD45A/CDKN1A/MYC/RPS6KB1/TCF7L2/MAPK10/SMAD3/JUN/SMAD2/RAC1/NRAS/TGFA/CYCS/BRAF/MAPK8/MAPK9/PIK3CB/PIK3R2/MAP2K2/AKT2/RHOA/PIK3CA/GSK3B/BIRC5/APC2/BBC3/SOS2/AXIN2/DCC/PIK3R1/CASP9/PMAIP1/APPL1/RALGDS	66	http://www.kegg.jp/kegg-bin/show_pathway?hsa05210/TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/EGFR/LEF1/BCL2/GRB2/CTNNB1/MTOR/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/MLH1/MSH2/MAP2K1/BAX/BCL2L11/EREG/MSH6/MSH3/CASP3/TGFB1/FOS/APC/HRAS/GADD45A/CDKN1A/MYC/RPS6KB1/TCF7L2/MAPK10/SMAD3/JUN/SMAD2/RAC1/NRAS/TGFA/CYCS/BRAF/MAPK8/MAPK9/PIK3CB/PIK3R2/MAP2K2/AKT2/RHOA/PIK3CA/GSK3B/BIRC5/APC2/BBC3/SOS2/AXIN2/DCC/PIK3R1/CASP9/PMAIP1/APPL1/RALGDS
hsa04110	Cell cycle	87/3197	124/8019	5.95570961603808e-12	6.41231401993433e-10	3.74060358340637e-10	TP53/CDC25B/BUB1/CCND1/TGFB2/PLK1/CDC25C/FZR1/ESPL1/E2F1/RAD21/SMC3/SMAD4/CCNE2/CCNE1/STAG2/CDC25A/CDKN1C/CDK2/ATM/SMC1A/CCNB1/CDKN1B/BUB3/TGFB1/HDAC2/PCNA/CHEK1/MAD2L2/CDC27/CDC23/ANAPC11/RB1/MAD2L1/CDC6/ANAPC1/EP300/MDM2/GADD45A/E2F4/CDKN1A/TFDP1/SFN/ORC1/CHEK2/CDKN2B/CDC45/WEE1/TFDP2/CDC14B/CCND3/CDK7/CCNA2/CDKN2A/CCND2/CDK4/CUL1/MYC/MCM4/RBL1/CDC7/MCM3/ORC4/MCM5/MCM2/ORC2/ORC5/MCM7/CDK6/YWHAE/SKP1/RBX1/YWHAG/HDAC1/SMAD3/E2F5/SMAD2/E2F2/CREBBP/E2F3/ABL1/YWHAB/GSK3B/CDC14A/YWHAH/YWHAZ/YWHAQ	87	http://www.kegg.jp/kegg-bin/show_pathway?hsa04110/TP53/CDC25B/BUB1/CCND1/TGFB2/PLK1/CDC25C/FZR1/ESPL1/E2F1/RAD21/SMC3/SMAD4/CCNE2/CCNE1/STAG2/CDC25A/CDKN1C/CDK2/ATM/SMC1A/CCNB1/CDKN1B/BUB3/TGFB1/HDAC2/PCNA/CHEK1/MAD2L2/CDC27/CDC23/ANAPC11/RB1/MAD2L1/CDC6/ANAPC1/EP300/MDM2/GADD45A/E2F4/CDKN1A/TFDP1/SFN/ORC1/CHEK2/CDKN2B/CDC45/WEE1/TFDP2/CDC14B/CCND3/CDK7/CCNA2/CDKN2A/CCND2/CDK4/CUL1/MYC/MCM4/RBL1/CDC7/MCM3/ORC4/MCM5/MCM2/ORC2/ORC5/MCM7/CDK6/YWHAE/SKP1/RBX1/YWHAG/HDAC1/SMAD3/E2F5/SMAD2/E2F2/CREBBP/E2F3/ABL1/YWHAB/GSK3B/CDC14A/YWHAH/YWHAZ/YWHAQ
hsa04010	MAPK signaling pathway	174/3197	295/8019	1.16491725702871e-11	9.40670685050684e-10	5.48737339495103e-10	TP53/AKT3/CDC25B/MAPK14/MAPK3/TGFB2/IL1B/DUSP1/PRKACB/TGFBR1/KRAS/VEGFA/EGFR/ARRB1/GRB2/PDGFRA/MAPK1/SOS1/AKT1/IGF2/CSF1/TGFBR2/KIT/PDGFB/MAP3K4/CRKL/MAP2K6/MAP2K1/FLNA/ARRB2/STK3/IGF1/HSPA2/PDGFRB/EREG/STK4/ANGPT2/KITLG/CASP3/TGFB1/MAPK8IP2/FOS/HRAS/MAP3K20/GADD45A/ATF2/TAOK1/MYC/PPP3CA/TNF/MAPK10/HSPA1A/TRAF6/MAP2K5/JUN/EFNA1/ELK4/MEF2C/FGFR1/SRF/PPM1A/NFATC3/MAP3K7/RASGRP1/RAC1/MAP4K2/CDC42/MAPK8IP3/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PDGFC/CACNA1A/IKBKG/DUSP6/BRAF/MAP2K4/DAXX/RAPGEF2/MAPK8/PAK2/IGF1R/ERBB2/KDR/IRAK4/PAK1/ERBB3/MAP3K13/RASGRP3/NLK/FGF19/MAP3K11/MAP3K8/FAS/IRAK1/MAP3K3/MAPK7/MAPK9/DUSP8/MAP2K7/TAB2/FLT1/MAP3K12/RRAS/ERBB4/DUSP16/RAP1B/DUSP7/CRK/DUSP3/FGF2/MET/FGF5/MAP3K2/MAPKAPK5/MAP3K5/PRKCA/MAP2K2/DUSP5/TAB1/FGFR3/MAP2K3/FGF7/RASA1/RAP1A/DUSP4/DUSP10/FGF23/PPP5C/FGFR4/MAPKAPK2/HGF/DUSP2/GNA12/HSPA1B/AKT2/RPS6KA2/PRKCB/HSPA8/RPS6KA4/MKNK2/MRAS/RPS6KA3/HSPA6/RPS6KA5/RRAS2/MAPT/EFNA5/STMN1/NFATC1/SOS2/EFNA3/BDNF/CACNG7/NGFR/ELK1/ATF4/NFKB2/CACNA1C/VEGFB/ANGPT4/PLA2G4A/IL1RAP/PPP3R1/TRADD/GNG12/CACNA1E/CACNG6/CACNG1/CACNG8/PLA2G4D/PPP5D1	174	http://www.kegg.jp/kegg-bin/show_pathway?hsa04010/TP53/AKT3/CDC25B/MAPK14/MAPK3/TGFB2/IL1B/DUSP1/PRKACB/TGFBR1/KRAS/VEGFA/EGFR/ARRB1/GRB2/PDGFRA/MAPK1/SOS1/AKT1/IGF2/CSF1/TGFBR2/KIT/PDGFB/MAP3K4/CRKL/MAP2K6/MAP2K1/FLNA/ARRB2/STK3/IGF1/HSPA2/PDGFRB/EREG/STK4/ANGPT2/KITLG/CASP3/TGFB1/MAPK8IP2/FOS/HRAS/MAP3K20/GADD45A/ATF2/TAOK1/MYC/PPP3CA/TNF/MAPK10/HSPA1A/TRAF6/MAP2K5/JUN/EFNA1/ELK4/MEF2C/FGFR1/SRF/PPM1A/NFATC3/MAP3K7/RASGRP1/RAC1/MAP4K2/CDC42/MAPK8IP3/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PDGFC/CACNA1A/IKBKG/DUSP6/BRAF/MAP2K4/DAXX/RAPGEF2/MAPK8/PAK2/IGF1R/ERBB2/KDR/IRAK4/PAK1/ERBB3/MAP3K13/RASGRP3/NLK/FGF19/MAP3K11/MAP3K8/FAS/IRAK1/MAP3K3/MAPK7/MAPK9/DUSP8/MAP2K7/TAB2/FLT1/MAP3K12/RRAS/ERBB4/DUSP16/RAP1B/DUSP7/CRK/DUSP3/FGF2/MET/FGF5/MAP3K2/MAPKAPK5/MAP3K5/PRKCA/MAP2K2/DUSP5/TAB1/FGFR3/MAP2K3/FGF7/RASA1/RAP1A/DUSP4/DUSP10/FGF23/PPP5C/FGFR4/MAPKAPK2/HGF/DUSP2/GNA12/HSPA1B/AKT2/RPS6KA2/PRKCB/HSPA8/RPS6KA4/MKNK2/MRAS/RPS6KA3/HSPA6/RPS6KA5/RRAS2/MAPT/EFNA5/STMN1/NFATC1/SOS2/EFNA3/BDNF/CACNG7/NGFR/ELK1/ATF4/NFKB2/CACNA1C/VEGFB/ANGPT4/PLA2G4A/IL1RAP/PPP3R1/TRADD/GNG12/CACNA1E/CACNG6/CACNG1/CACNG8/PLA2G4D/PPP5D1
hsa05132	Salmonella infection	132/3197	214/8019	5.60044714409619e-11	3.37593791459132e-09	1.96934295816147e-09	AKT3/MAPK14/MAPK3/BAK1/MYH9/IL1B/TNFSF10/LEF1/BCL2/CTNNB1/CASP8/MAPK1/AKT1/HSP90AB1/DNM2/MAP2K6/MAP2K1/FLNA/BAX/BIRC3/BIRC2/CASP3/FOS/PTPRC/KPNA1/PIK3C3/RAB5A/DYNC1LI1/HRAS/ACTB/MYC/HSP90AA1/SKP1/DYNC1H1/TCF7L2/TNF/MAPK10/TRAF6/JUN/TXN/MAP3K7/RAC1/NLRP3/CDC42/PYCARD/ARF1/M6PR/CYTH2/CYTH3/EXOC2/EXOC7/EXOC5/MYH14/MYH2/MYO6/WASL/VPS18/IKBKG/CYCS/MAP2K4/PAK3/MAPK8/ROCK2/IRAK4/PAK1/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/RRAS/TLR6/MAP2K2/TAB1/TIRAP/MAP2K3/IL18/RPS3/NAIP/AKT2/MYH11/RHOA/RAB5B/RAB5C/RHOH/HSP90B1/ARF6/GAPDH/RHOG/RHOB/ACTG1/PFN1/DYNC1LI2/RAB9B/SNX9/SNX33/KPNA4/VPS39/FYCO1/ANXA2/VPS33A/PLEKHM1/CYFIP2/ARHGEF26/FGD4/WASF3/ARPC2/S100A10/NCKAP1/TLR2/PFN2/CXCL8/PODXL/MYL12A/ARPC5/TLR5/TNFRSF10B/TNFRSF10A/TRADD/ARPC1B/ARPC4/DYNLL2/KLC2/KPNA3/ARPC5L/DYNC2LI1/CSE1L/AHNAK2/PFN4/PLEKHM2/CASP7/CASP5	132	http://www.kegg.jp/kegg-bin/show_pathway?hsa05132/AKT3/MAPK14/MAPK3/BAK1/MYH9/IL1B/TNFSF10/LEF1/BCL2/CTNNB1/CASP8/MAPK1/AKT1/HSP90AB1/DNM2/MAP2K6/MAP2K1/FLNA/BAX/BIRC3/BIRC2/CASP3/FOS/PTPRC/KPNA1/PIK3C3/RAB5A/DYNC1LI1/HRAS/ACTB/MYC/HSP90AA1/SKP1/DYNC1H1/TCF7L2/TNF/MAPK10/TRAF6/JUN/TXN/MAP3K7/RAC1/NLRP3/CDC42/PYCARD/ARF1/M6PR/CYTH2/CYTH3/EXOC2/EXOC7/EXOC5/MYH14/MYH2/MYO6/WASL/VPS18/IKBKG/CYCS/MAP2K4/PAK3/MAPK8/ROCK2/IRAK4/PAK1/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/RRAS/TLR6/MAP2K2/TAB1/TIRAP/MAP2K3/IL18/RPS3/NAIP/AKT2/MYH11/RHOA/RAB5B/RAB5C/RHOH/HSP90B1/ARF6/GAPDH/RHOG/RHOB/ACTG1/PFN1/DYNC1LI2/RAB9B/SNX9/SNX33/KPNA4/VPS39/FYCO1/ANXA2/VPS33A/PLEKHM1/CYFIP2/ARHGEF26/FGD4/WASF3/ARPC2/S100A10/NCKAP1/TLR2/PFN2/CXCL8/PODXL/MYL12A/ARPC5/TLR5/TNFRSF10B/TNFRSF10A/TRADD/ARPC1B/ARPC4/DYNLL2/KLC2/KPNA3/ARPC5L/DYNC2LI1/CSE1L/AHNAK2/PFN4/PLEKHM2/CASP7/CASP5
hsa05211	Renal cell carcinoma	54/3197	69/8019	7.58260125456461e-11	3.37593791459132e-09	1.96934295816147e-09	AKT3/FLCN/MAPK3/TGFB2/KRAS/VEGFA/GRB2/MAPK1/SOS1/AKT1/ETS1/PDGFB/SLC2A1/CRKL/MAP2K1/EPAS1/ARNT/PTPN11/TGFB1/HIF1A/HRAS/EP300/CDKN1A/CUL2/RBX1/JUN/VHL/CREBBP/RAC1/CDC42/NRAS/TGFA/ELOB/BRAF/PAK3/PAK2/PAK4/PAK1/RAP1B/CRK/MET/PIK3CB/PIK3R2/MAP2K2/RAP1A/HGF/RAPGEF1/AKT2/PIK3CA/SOS2/PIK3R1/TFE3/EGLN3/ELOC	54	http://www.kegg.jp/kegg-bin/show_pathway?hsa05211/AKT3/FLCN/MAPK3/TGFB2/KRAS/VEGFA/GRB2/MAPK1/SOS1/AKT1/ETS1/PDGFB/SLC2A1/CRKL/MAP2K1/EPAS1/ARNT/PTPN11/TGFB1/HIF1A/HRAS/EP300/CDKN1A/CUL2/RBX1/JUN/VHL/CREBBP/RAC1/CDC42/NRAS/TGFA/ELOB/BRAF/PAK3/PAK2/PAK4/PAK1/RAP1B/CRK/MET/PIK3CB/PIK3R2/MAP2K2/RAP1A/HGF/RAPGEF1/AKT2/PIK3CA/SOS2/PIK3R1/TFE3/EGLN3/ELOC
hsa04218	Cellular senescence	104/3197	160/8019	8.00739783198223e-11	3.37593791459132e-09	1.96934295816147e-09	TP53/AKT3/MAPK14/MAPK3/CCND1/TGFB2/SIRT1/TGFBR1/KRAS/MRE11/FOXO3/E2F1/MTOR/MAPK1/AKT1/ETS1/CCNE2/VDAC2/TGFBR2/CCNE1/PTEN/CDC25A/MAP2K6/MAP2K1/ZFP36L1/CDK2/ATM/CCNB1/TGFB1/CHEK1/RB1/HRAS/MDM2/GADD45A/E2F4/CDKN1A/CHEK2/CDKN2B/CCND3/CCNA2/CDKN2A/CCND2/CDK4/MYC/RBL1/PPP3CA/EIF4EBP1/CDK6/FBXW11/CALM3/BTRC/PPP1CB/FOXM1/RBBP4/FOXO1/SMAD3/NFATC2/E2F5/SMAD2/SQSTM1/E2F2/NFATC3/E2F3/HIPK2/HLA-A/HLA-B/HLA-C/HLA-E/NRAS/PPP1CC/RRAS/CALM1/PIK3CB/HIPK3/PIK3R2/MAP2K2/MAP2K3/IGFBP3/MAPKAPK2/ZFP36L2/AKT2/PIK3CA/TRPM7/MRAS/HIPK1/RRAS2/MYBL2/NFATC1/SLC25A6/CAPN1/VDAC1/PIK3R1/CALM2/LIN54/SERPINE1/CXCL8/ITPR2/ITPR1/TRAF3IP2/PPP3R1/MCU/RASSF5/CALML4/LIN52	104	http://www.kegg.jp/kegg-bin/show_pathway?hsa04218/TP53/AKT3/MAPK14/MAPK3/CCND1/TGFB2/SIRT1/TGFBR1/KRAS/MRE11/FOXO3/E2F1/MTOR/MAPK1/AKT1/ETS1/CCNE2/VDAC2/TGFBR2/CCNE1/PTEN/CDC25A/MAP2K6/MAP2K1/ZFP36L1/CDK2/ATM/CCNB1/TGFB1/CHEK1/RB1/HRAS/MDM2/GADD45A/E2F4/CDKN1A/CHEK2/CDKN2B/CCND3/CCNA2/CDKN2A/CCND2/CDK4/MYC/RBL1/PPP3CA/EIF4EBP1/CDK6/FBXW11/CALM3/BTRC/PPP1CB/FOXM1/RBBP4/FOXO1/SMAD3/NFATC2/E2F5/SMAD2/SQSTM1/E2F2/NFATC3/E2F3/HIPK2/HLA-A/HLA-B/HLA-C/HLA-E/NRAS/PPP1CC/RRAS/CALM1/PIK3CB/HIPK3/PIK3R2/MAP2K2/MAP2K3/IGFBP3/MAPKAPK2/ZFP36L2/AKT2/PIK3CA/TRPM7/MRAS/HIPK1/RRAS2/MYBL2/NFATC1/SLC25A6/CAPN1/VDAC1/PIK3R1/CALM2/LIN54/SERPINE1/CXCL8/ITPR2/ITPR1/TRAF3IP2/PPP3R1/MCU/RASSF5/CALML4/LIN52
hsa05215	Prostate cancer	70/3197	97/8019	9.11428017319207e-11	3.37593791459132e-09	1.96934295816147e-09	TP53/AKT3/MAPK3/CCND1/AR/KRAS/EGFR/LEF1/BCL2/GRB2/PDGFRA/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/CCNE2/CCNE1/PTEN/PDGFB/HSP90AB1/MAP2K1/CDK2/IGF1/PDGFRB/CDKN1B/MMP9/ETV5/RB1/HRAS/EP300/MDM2/CDKN1A/HSP90AA1/TCF7L2/FOXO1/E2F2/FGFR1/ZEB1/CREBBP/E2F3/CREB3/NRAS/TGFA/PDGFA/PDGFD/PDGFC/IKBKG/BRAF/IGF1R/ERBB2/PIK3CB/PIK3R2/MAP2K2/GSTP1/PDPK1/AKT2/PIK3CA/HSP90B1/GSK3B/CREB1/SOS2/CREB3L2/PIK3R1/CASP9/ERG/ATF4/CREB5/PLAT	70	http://www.kegg.jp/kegg-bin/show_pathway?hsa05215/TP53/AKT3/MAPK3/CCND1/AR/KRAS/EGFR/LEF1/BCL2/GRB2/PDGFRA/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/CCNE2/CCNE1/PTEN/PDGFB/HSP90AB1/MAP2K1/CDK2/IGF1/PDGFRB/CDKN1B/MMP9/ETV5/RB1/HRAS/EP300/MDM2/CDKN1A/HSP90AA1/TCF7L2/FOXO1/E2F2/FGFR1/ZEB1/CREBBP/E2F3/CREB3/NRAS/TGFA/PDGFA/PDGFD/PDGFC/IKBKG/BRAF/IGF1R/ERBB2/PIK3CB/PIK3R2/MAP2K2/GSTP1/PDPK1/AKT2/PIK3CA/HSP90B1/GSK3B/CREB1/SOS2/CREB3L2/PIK3R1/CASP9/ERG/ATF4/CREB5/PLAT
hsa05225	Hepatocellular carcinoma	108/3197	168/8019	9.40663815211203e-11	3.37593791459132e-09	1.96934295816147e-09	TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/WNT9B/TGFBR1/KRAS/FZD5/EGFR/LEF1/GRB2/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/SMAD4/WNT5A/IGF2/TGFBR2/LRP6/PTEN/BCL2L1/FZD4/MAP2K1/SMARCA2/WNT7A/BAX/WNT4/TGFB1/WNT7B/ARID1A/TERT/RB1/APC/HRAS/GADD45A/CDKN1A/ACTB/CDKN2A/CDK4/MYC/RPS6KB1/CDK6/BRD7/TCF7L2/SMAD3/SMARCA4/SMAD2/E2F2/FZD8/E2F3/ACTL6A/DPF3/DPF1/NRAS/TGFA/BRAF/WNT16/IGF1R/DVL3/SHC3/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/GSTP1/DVL2/FZD7/HGF/AKT2/PRKCB/PIK3CA/CSNK1A1/ACTG1/GSK3B/APC2/SMARCD2/ARID1B/SMARCD1/SMARCB1/SMARCC2/LRP5/NFE2L2/SOS2/AXIN2/PLCG1/PIK3R1/ELK1/ARID2/WNT8B/FZD9/FZD1/WNT10A/GSTM4/FZD6/FZD2/PLCG2/GSTM3/GSTO1/MGST3/SHC4/GSTO2/FRAT2	108	http://www.kegg.jp/kegg-bin/show_pathway?hsa05225/TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/WNT9B/TGFBR1/KRAS/FZD5/EGFR/LEF1/GRB2/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/SMAD4/WNT5A/IGF2/TGFBR2/LRP6/PTEN/BCL2L1/FZD4/MAP2K1/SMARCA2/WNT7A/BAX/WNT4/TGFB1/WNT7B/ARID1A/TERT/RB1/APC/HRAS/GADD45A/CDKN1A/ACTB/CDKN2A/CDK4/MYC/RPS6KB1/CDK6/BRD7/TCF7L2/SMAD3/SMARCA4/SMAD2/E2F2/FZD8/E2F3/ACTL6A/DPF3/DPF1/NRAS/TGFA/BRAF/WNT16/IGF1R/DVL3/SHC3/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/GSTP1/DVL2/FZD7/HGF/AKT2/PRKCB/PIK3CA/CSNK1A1/ACTG1/GSK3B/APC2/SMARCD2/ARID1B/SMARCD1/SMARCB1/SMARCC2/LRP5/NFE2L2/SOS2/AXIN2/PLCG1/PIK3R1/ELK1/ARID2/WNT8B/FZD9/FZD1/WNT10A/GSTM4/FZD6/FZD2/PLCG2/GSTM3/GSTO1/MGST3/SHC4/GSTO2/FRAT2
hsa04933	AGE-RAGE signaling pathway in diabetic complications	71/3197	100/8019	2.26140738870424e-10	6.94999099873596e-09	4.05425578873631e-09	AKT3/MAPK14/MAPK3/CCND1/TGFB2/IL1B/TGFBR1/KRAS/VEGFA/BCL2/MMP2/MAPK1/AKT1/SMAD4/TGFBR2/ICAM1/EGR1/EDN1/PLCD1/BAX/CDKN1B/CASP3/PLCD3/TGFB1/STAT3/HRAS/CDK4/CCL2/TNF/MAPK10/FOXO1/SMAD3/JUN/STAT1/SMAD2/RAC1/CDC42/NRAS/PLCE1/MAPK8/PRKCD/MAPK9/FN1/PIK3CB/JAK2/PRKCA/PIK3R2/AKT2/PRKCB/PIK3CA/PIM1/CYBB/NFATC1/COL1A1/PLCG1/DIAPH1/PIK3R1/COL4A4/STAT5A/COL1A2/COL3A1/COL4A1/SERPINE1/CXCL8/VEGFB/COL4A2/F3/VCAM1/PLCG2/SELE/COL4A5	71	http://www.kegg.jp/kegg-bin/show_pathway?hsa04933/AKT3/MAPK14/MAPK3/CCND1/TGFB2/IL1B/TGFBR1/KRAS/VEGFA/BCL2/MMP2/MAPK1/AKT1/SMAD4/TGFBR2/ICAM1/EGR1/EDN1/PLCD1/BAX/CDKN1B/CASP3/PLCD3/TGFB1/STAT3/HRAS/CDK4/CCL2/TNF/MAPK10/FOXO1/SMAD3/JUN/STAT1/SMAD2/RAC1/CDC42/NRAS/PLCE1/MAPK8/PRKCD/MAPK9/FN1/PIK3CB/JAK2/PRKCA/PIK3R2/AKT2/PRKCB/PIK3CA/PIM1/CYBB/NFATC1/COL1A1/PLCG1/DIAPH1/PIK3R1/COL4A4/STAT5A/COL1A2/COL3A1/COL4A1/SERPINE1/CXCL8/VEGFB/COL4A2/F3/VCAM1/PLCG2/SELE/COL4A5
hsa05161	Hepatitis B	104/3197	162/8019	2.36686999956952e-10	6.94999099873596e-09	4.05425578873631e-09	TP53/AKT3/MAPK14/MAPK3/TGFB2/TGFBR1/KRAS/BCL2/GRB2/CASP8/E2F1/MAPK1/SOS1/AKT1/SMAD4/CCNE2/TGFBR2/CCNE1/MAP2K6/MAP2K1/SRC/CDK2/DDX3X/BAX/MMP9/CASP3/TGFB1/STAT3/FOS/PCNA/ATP6AP1/RB1/HRAS/EP300/CDKN1A/ATF2/CCNA2/MYC/BID/TNF/MAPK10/SMAD3/TRAF6/NFATC2/JUN/STAT1/E2F2/CREBBP/NFATC3/E2F3/MAP3K7/CREB3/NRAS/DDB1/IKBKG/CYCS/BRAF/MAP2K4/MAPK8/YWHAB/IRAK4/FAS/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/TAB1/TIRAP/MAP2K3/AKT2/PRKCB/PIK3CA/APAF1/TBK1/BIRC5/CREB1/NFATC1/STAT2/IFNAR1/SOS2/CREB3L2/PIK3R1/CASP9/EGR2/ATF6B/ELK1/ATF4/STAT5A/EGR3/CREB5/TLR2/TICAM1/CXCL8/IFNB1/YWHAZ/TRAF3/MAVS/YWHAQ	104	http://www.kegg.jp/kegg-bin/show_pathway?hsa05161/TP53/AKT3/MAPK14/MAPK3/TGFB2/TGFBR1/KRAS/BCL2/GRB2/CASP8/E2F1/MAPK1/SOS1/AKT1/SMAD4/CCNE2/TGFBR2/CCNE1/MAP2K6/MAP2K1/SRC/CDK2/DDX3X/BAX/MMP9/CASP3/TGFB1/STAT3/FOS/PCNA/ATP6AP1/RB1/HRAS/EP300/CDKN1A/ATF2/CCNA2/MYC/BID/TNF/MAPK10/SMAD3/TRAF6/NFATC2/JUN/STAT1/E2F2/CREBBP/NFATC3/E2F3/MAP3K7/CREB3/NRAS/DDB1/IKBKG/CYCS/BRAF/MAP2K4/MAPK8/YWHAB/IRAK4/FAS/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/TAB1/TIRAP/MAP2K3/AKT2/PRKCB/PIK3CA/APAF1/TBK1/BIRC5/CREB1/NFATC1/STAT2/IFNAR1/SOS2/CREB3L2/PIK3R1/CASP9/EGR2/ATF6B/ELK1/ATF4/STAT5A/EGR3/CREB5/TLR2/TICAM1/CXCL8/IFNB1/YWHAZ/TRAF3/MAVS/YWHAQ
hsa01521	EGFR tyrosine kinase inhibitor resistance	59/3197	79/8019	2.90622975944595e-10	7.82260176917536e-09	4.56329058720023e-09	AKT3/MAPK3/RPS6/KRAS/VEGFA/EGFR/BCL2/AXL/FOXO3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/PTEN/PDGFB/BCL2L1/MAP2K1/SRC/BAX/BCL2L11/IGF1/PDGFRB/STAT3/HRAS/EIF4E/RPS6KB1/EIF4EBP1/NRAS/TGFA/PDGFA/PDGFD/PDGFC/BRAF/IGF1R/ERBB2/KDR/ERBB3/SHC3/FGF2/MET/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/FGFR3/HGF/AKT2/PRKCB/PIK3CA/GSK3B/SOS2/PLCG1/PIK3R1/IL6R/PLCG2/SHC4	59	http://www.kegg.jp/kegg-bin/show_pathway?hsa01521/AKT3/MAPK3/RPS6/KRAS/VEGFA/EGFR/BCL2/AXL/FOXO3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/PTEN/PDGFB/BCL2L1/MAP2K1/SRC/BAX/BCL2L11/IGF1/PDGFRB/STAT3/HRAS/EIF4E/RPS6KB1/EIF4EBP1/NRAS/TGFA/PDGFA/PDGFD/PDGFC/BRAF/IGF1R/ERBB2/KDR/ERBB3/SHC3/FGF2/MET/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/FGFR3/HGF/AKT2/PRKCB/PIK3CA/GSK3B/SOS2/PLCG1/PIK3R1/IL6R/PLCG2/SHC4
hsa04510	Focal adhesion	122/3197	199/8019	5.29356250322514e-10	1.31524668349363e-08	7.67245091560567e-09	AKT3/MAPK3/CCND1/VEGFA/EGFR/BCL2/GRB2/PDGFRA/CTNNB1/MAPK1/SOS1/AKT1/PTEN/PDGFB/ITGA5/CRKL/MAP2K1/SRC/FLNA/ITGB1/IGF1/PDGFRB/ITGB8/TNC/BIRC3/ITGA3/ITGA2/BIRC2/HRAS/ACTB/CCND3/CCND2/PPP1R12B/PPP1R12A/PPP1CB/MAPK10/JUN/ARHGAP35/RAC1/CDC42/ROCK1/PDGFA/PDGFD/CAV2/PDGFC/PPP1CC/BRAF/PAK3/MAPK8/PAK2/IGF1R/ERBB2/KDR/ROCK2/PAK4/PAK1/ITGA1/THBS1/MAPK9/FLT1/SHC3/FN1/RAP1B/CRK/MET/FYN/PIK3CB/PRKCA/PIK3R2/RAP1A/HGF/RAPGEF1/ILK/PDPK1/AKT2/PRKCB/RHOA/PIK3CA/MYLK3/ACTG1/GSK3B/MYLK4/XIAP/PXN/COL1A1/COL6A1/SOS2/LAMA2/ITGA7/DIAPH1/VCL/PIK3R1/PARVB/DOCK1/TNR/LAMC1/ACTN4/COL4A4/ITGA8/ITGB3/VASP/ACTN1/ELK1/COL1A2/COL4A1/COL9A2/ITGA11/VEGFB/THBS2/COL4A2/VAV2/VAV3/BCAR1/ITGB4/LAMA4/ZYX/TLN1/MYL12A/ITGA9/SHC4/COL4A5/PPP1R12C	122	http://www.kegg.jp/kegg-bin/show_pathway?hsa04510/AKT3/MAPK3/CCND1/VEGFA/EGFR/BCL2/GRB2/PDGFRA/CTNNB1/MAPK1/SOS1/AKT1/PTEN/PDGFB/ITGA5/CRKL/MAP2K1/SRC/FLNA/ITGB1/IGF1/PDGFRB/ITGB8/TNC/BIRC3/ITGA3/ITGA2/BIRC2/HRAS/ACTB/CCND3/CCND2/PPP1R12B/PPP1R12A/PPP1CB/MAPK10/JUN/ARHGAP35/RAC1/CDC42/ROCK1/PDGFA/PDGFD/CAV2/PDGFC/PPP1CC/BRAF/PAK3/MAPK8/PAK2/IGF1R/ERBB2/KDR/ROCK2/PAK4/PAK1/ITGA1/THBS1/MAPK9/FLT1/SHC3/FN1/RAP1B/CRK/MET/FYN/PIK3CB/PRKCA/PIK3R2/RAP1A/HGF/RAPGEF1/ILK/PDPK1/AKT2/PRKCB/RHOA/PIK3CA/MYLK3/ACTG1/GSK3B/MYLK4/XIAP/PXN/COL1A1/COL6A1/SOS2/LAMA2/ITGA7/DIAPH1/VCL/PIK3R1/PARVB/DOCK1/TNR/LAMC1/ACTN4/COL4A4/ITGA8/ITGB3/VASP/ACTN1/ELK1/COL1A2/COL4A1/COL9A2/ITGA11/VEGFB/THBS2/COL4A2/VAV2/VAV3/BCAR1/ITGB4/LAMA4/ZYX/TLN1/MYL12A/ITGA9/SHC4/COL4A5/PPP1R12C
hsa05214	Glioma	56/3197	75/8019	8.41395400482111e-10	1.94121938825516e-08	1.1324043359872e-08	TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/GRB2/PDGFRA/E2F1/MTOR/MAPK1/SOS1/AKT1/PTEN/PDGFB/MAP2K1/BAX/IGF1/PDGFRB/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/CAMK2A/CDK6/CALM3/E2F2/E2F3/NRAS/TGFA/PDGFA/BRAF/IGF1R/SHC3/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/AKT2/PRKCB/PIK3CA/CAMK2G/CAMK4/CAMK1D/SOS2/PLCG1/PIK3R1/CALM2/PLCG2/SHC4/CALML4	56	http://www.kegg.jp/kegg-bin/show_pathway?hsa05214/TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/GRB2/PDGFRA/E2F1/MTOR/MAPK1/SOS1/AKT1/PTEN/PDGFB/MAP2K1/BAX/IGF1/PDGFRB/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/CAMK2A/CDK6/CALM3/E2F2/E2F3/NRAS/TGFA/PDGFA/BRAF/IGF1R/SHC3/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/AKT2/PRKCB/PIK3CA/CAMK2G/CAMK4/CAMK1D/SOS2/PLCG1/PIK3R1/CALM2/PLCG2/SHC4/CALML4
hsa04068	FoxO signaling pathway	86/3197	131/8019	1.68739802487769e-09	3.63353041356997e-08	2.11960874703935e-08	AKT3/MAPK14/MAPK3/CCND1/TGFB2/TNFSF10/PLK1/SIRT1/TGFBR1/KRAS/EGFR/FOXO3/GRB2/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/PTEN/MAP2K1/CDK2/ATM/STK11/BCL2L11/IGF1/CCNB1/CDKN1B/STK4/PRKAG1/BCL6/TGFB1/STAT3/IL7R/GABARAPL1/GABARAP/ATG12/HRAS/EP300/MDM2/GADD45A/CDKN1A/CDKN2B/FOXO4/CCND2/CSNK1E/MAPK10/FOXO1/SMAD3/FOXO6/KLF2/CREBBP/NRAS/FBXO32/FBXO25/BRAF/MAPK8/IGF1R/NLK/MAPK9/IRS2/PIK3CB/PIK3R2/MAP2K2/IRS1/PRKAA1/PDPK1/AKT2/PIK3CA/SGK3/C8orf44-SGK3/PCK1/SGK1/PRKAA2/BNIP3/G6PC/SOD2/USP7/SOS2/PIK3R1/S1PR1/PRKAB1/PRKAB2/RAG1/HOMER2/SETD7/IRS4	86	http://www.kegg.jp/kegg-bin/show_pathway?hsa04068/AKT3/MAPK14/MAPK3/CCND1/TGFB2/TNFSF10/PLK1/SIRT1/TGFBR1/KRAS/EGFR/FOXO3/GRB2/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/PTEN/MAP2K1/CDK2/ATM/STK11/BCL2L11/IGF1/CCNB1/CDKN1B/STK4/PRKAG1/BCL6/TGFB1/STAT3/IL7R/GABARAPL1/GABARAP/ATG12/HRAS/EP300/MDM2/GADD45A/CDKN1A/CDKN2B/FOXO4/CCND2/CSNK1E/MAPK10/FOXO1/SMAD3/FOXO6/KLF2/CREBBP/NRAS/FBXO32/FBXO25/BRAF/MAPK8/IGF1R/NLK/MAPK9/IRS2/PIK3CB/PIK3R2/MAP2K2/IRS1/PRKAA1/PDPK1/AKT2/PIK3CA/SGK3/C8orf44-SGK3/PCK1/SGK1/PRKAA2/BNIP3/G6PC/SOD2/USP7/SOS2/PIK3R1/S1PR1/PRKAB1/PRKAB2/RAG1/HOMER2/SETD7/IRS4
hsa04520	Adherens junction	53/3197	71/8019	2.43663370462599e-09	4.91895429121372e-08	2.86945679689508e-08	MAPK3/TGFBR1/EGFR/LEF1/CTNNA1/CTNNB1/MAPK1/SMAD4/TGFBR2/SNAI1/NECTIN3/SRC/NECTIN1/EP300/ACTB/PTPN6/CSNK2A1/TCF7L2/SMAD3/FGFR1/CREBBP/SNAI2/MAP3K7/RAC1/CDC42/WASL/IGF1R/ERBB2/NLK/PTPRJ/IQGAP1/MET/FYN/PTPN1/RHOA/YES1/FER/ACTG1/SSX2IP/PARD3/VCL/CDH1/WASF3/ACTN4/BAIAP2/WASF2/ACTN1/CTNNA3/PTPRB/TJP1/PTPRF/ACP1/CTNND1	53	http://www.kegg.jp/kegg-bin/show_pathway?hsa04520/MAPK3/TGFBR1/EGFR/LEF1/CTNNA1/CTNNB1/MAPK1/SMAD4/TGFBR2/SNAI1/NECTIN3/SRC/NECTIN1/EP300/ACTB/PTPN6/CSNK2A1/TCF7L2/SMAD3/FGFR1/CREBBP/SNAI2/MAP3K7/RAC1/CDC42/WASL/IGF1R/ERBB2/NLK/PTPRJ/IQGAP1/MET/FYN/PTPN1/RHOA/YES1/FER/ACTG1/SSX2IP/PARD3/VCL/CDH1/WASF3/ACTN4/BAIAP2/WASF2/ACTN1/CTNNA3/PTPRB/TJP1/PTPRF/ACP1/CTNND1
hsa01522	Endocrine resistance	68/3197	98/8019	2.63797115329595e-09	5.01214519126231e-08	2.92381942068097e-08	TP53/AKT3/MAPK14/MAPK3/CCND1/PRKACB/KRAS/EGFR/BCL2/GRB2/MMP2/E2F1/ESR1/MTOR/MAPK1/SOS1/AKT1/MAP2K1/SRC/BAX/IGF1/NOTCH1/CDKN1B/MMP9/JAG2/FOS/RB1/HRAS/MDM2/CDKN1A/CARM1/CDKN2A/CDK4/RPS6KB1/NCOR1/MAPK10/JUN/NOTCH3/ESR2/E2F2/E2F3/DLL4/NOTCH2/NRAS/GPER1/BRAF/MAPK8/IGF1R/ERBB2/MAPK9/SHC3/PIK3CB/PIK3R2/MAP2K2/HBEGF/GNAS/AKT2/ADCY9/PIK3CA/ABCB11/ADCY2/ADCY5/NCOA3/SP1/SOS2/PIK3R1/JAG1/SHC4	68	http://www.kegg.jp/kegg-bin/show_pathway?hsa01522/TP53/AKT3/MAPK14/MAPK3/CCND1/PRKACB/KRAS/EGFR/BCL2/GRB2/MMP2/E2F1/ESR1/MTOR/MAPK1/SOS1/AKT1/MAP2K1/SRC/BAX/IGF1/NOTCH1/CDKN1B/MMP9/JAG2/FOS/RB1/HRAS/MDM2/CDKN1A/CARM1/CDKN2A/CDK4/RPS6KB1/NCOR1/MAPK10/JUN/NOTCH3/ESR2/E2F2/E2F3/DLL4/NOTCH2/NRAS/GPER1/BRAF/MAPK8/IGF1R/ERBB2/MAPK9/SHC3/PIK3CB/PIK3R2/MAP2K2/HBEGF/GNAS/AKT2/ADCY9/PIK3CA/ABCB11/ADCY2/ADCY5/NCOA3/SP1/SOS2/PIK3R1/JAG1/SHC4
hsa04722	Neurotrophin signaling pathway	79/3197	119/8019	3.57927130953232e-09	6.42280351654965e-08	3.74672259886716e-08	TP53/AKT3/MAPK14/MAPK3/KRAS/BCL2/FOXO3/GRB2/MAPK1/SOS1/AKT1/CRKL/MAP2K1/BAX/FRS2/PTPN11/PSEN1/HRAS/CAMK2A/YWHAE/CALM3/MAPK10/TRAF6/MAP2K5/JUN/RAC1/CDC42/NRAS/NTRK2/SORT1/ABL1/BRAF/MAPK8/IRAK4/SH2B3/PRKCD/IRAK1/MAP3K3/MAPK7/MAPK9/NTRK3/MAP2K7/SHC3/RAP1B/CRK/IRAK2/CALM1/PIK3CB/MAP3K5/PIK3R2/MAP2K2/RAP1A/IRS1/MAGED1/MAPKAPK2/RAPGEF1/PDPK1/AKT2/RPS6KA2/RHOA/PIK3CA/CAMK2G/RPS6KA3/RPS6KA5/GSK3B/CAMK4/SOS2/PLCG1/PIK3R1/BDNF/ARHGDIA/NGFR/CALM2/PRDM4/ATF4/PLCG2/SHC4/BEX3/CALML4	79	http://www.kegg.jp/kegg-bin/show_pathway?hsa04722/TP53/AKT3/MAPK14/MAPK3/KRAS/BCL2/FOXO3/GRB2/MAPK1/SOS1/AKT1/CRKL/MAP2K1/BAX/FRS2/PTPN11/PSEN1/HRAS/CAMK2A/YWHAE/CALM3/MAPK10/TRAF6/MAP2K5/JUN/RAC1/CDC42/NRAS/NTRK2/SORT1/ABL1/BRAF/MAPK8/IRAK4/SH2B3/PRKCD/IRAK1/MAP3K3/MAPK7/MAPK9/NTRK3/MAP2K7/SHC3/RAP1B/CRK/IRAK2/CALM1/PIK3CB/MAP3K5/PIK3R2/MAP2K2/RAP1A/IRS1/MAGED1/MAPKAPK2/RAPGEF1/PDPK1/AKT2/RPS6KA2/RHOA/PIK3CA/CAMK2G/RPS6KA3/RPS6KA5/GSK3B/CAMK4/SOS2/PLCG1/PIK3R1/BDNF/ARHGDIA/NGFR/CALM2/PRDM4/ATF4/PLCG2/SHC4/BEX3/CALML4
hsa05167	Kaposi sarcoma-associated herpesvirus infection	113/3197	186/8019	4.90873697059987e-09	8.34485285001978e-08	4.86794414258935e-08	TP53/AKT3/MAPK14/UBB/MAPK3/CCND1/BAK1/KRAS/VEGFA/PTGS2/CTNNB1/CASP8/E2F1/MTOR/MAPK1/AKT1/ICAM1/PDGFB/MAP2K6/MAP2K1/SRC/BAX/ANGPT2/CASP3/STAT3/FOS/HIF1A/GABARAPL1/BECN1/PIK3C3/GABARAP/ATG14/RB1/HRAS/EP300/CDKN1A/CDK4/MYC/BID/PPP3CA/CDK6/CALM3/MAPK10/NFATC2/JUN/STAT1/E2F2/CREBBP/ZFP36/NFATC3/E2F3/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/NRAS/IKBKG/CYCS/MAP2K4/MAPK8/CCR5/FAS/PIK3CG/MAPK9/MAP2K7/FGF2/EIF2AK2/SYK/CALM1/PIK3CB/JAK2/PIK3R2/MAP2K2/LYN/MAPKAPK2/AKT2/PIK3CA/GSK3B/TBK1/CREB1/NFATC1/STAT2/C3/GNB4/GNB2/IFNAR1/PLCG1/PIK3R1/CASP9/CALM2/MICB/GNG2/IL6ST/TICAM1/CXCL8/GNG4/CCR4/CXCL1/CXCL3/ITPR2/ITPR1/PLCG2/IFNB1/MICA/TRAF3/PPP3R1/TRADD/IFNAR2/GNG12/GNB5/GNG5/CALML4	113	http://www.kegg.jp/kegg-bin/show_pathway?hsa05167/TP53/AKT3/MAPK14/UBB/MAPK3/CCND1/BAK1/KRAS/VEGFA/PTGS2/CTNNB1/CASP8/E2F1/MTOR/MAPK1/AKT1/ICAM1/PDGFB/MAP2K6/MAP2K1/SRC/BAX/ANGPT2/CASP3/STAT3/FOS/HIF1A/GABARAPL1/BECN1/PIK3C3/GABARAP/ATG14/RB1/HRAS/EP300/CDKN1A/CDK4/MYC/BID/PPP3CA/CDK6/CALM3/MAPK10/NFATC2/JUN/STAT1/E2F2/CREBBP/ZFP36/NFATC3/E2F3/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/NRAS/IKBKG/CYCS/MAP2K4/MAPK8/CCR5/FAS/PIK3CG/MAPK9/MAP2K7/FGF2/EIF2AK2/SYK/CALM1/PIK3CB/JAK2/PIK3R2/MAP2K2/LYN/MAPKAPK2/AKT2/PIK3CA/GSK3B/TBK1/CREB1/NFATC1/STAT2/C3/GNB4/GNB2/IFNAR1/PLCG1/PIK3R1/CASP9/CALM2/MICB/GNG2/IL6ST/TICAM1/CXCL8/GNG4/CCR4/CXCL1/CXCL3/ITPR2/ITPR1/PLCG2/IFNB1/MICA/TRAF3/PPP3R1/TRADD/IFNAR2/GNG12/GNB5/GNG5/CALML4
hsa04140	Autophagy - animal	88/3197	137/8019	5.54398237827087e-09	8.95353154090745e-08	5.22301497742361e-08	AKT3/ATG7/MAPK3/PRKACB/KRAS/BCL2/CTSB/MTOR/MAPK1/AKT1/PTEN/VMP1/BCL2L1/MAP2K1/STK11/HIF1A/RAB1A/GABARAPL1/BECN1/RB1CC1/PIK3C3/GABARAP/ATG9A/ULK1/SH3GLB1/TP53INP2/MTMR3/WIPI2/ATG12/ATG14/ATG2A/RAB33B/AMBRA1/STX17/SMCR8/ATG2B/ULK2/EIF2AK4/HRAS/RPS6KB1/HMGB1/MAPK10/TRAF6/SQSTM1/SUPT20H/MAP3K7/NRAS/RAB8A/DAPK1/UVRAG/PPP2CB/MAPK8/IGF1R/CAMKK2/PRKCD/MAPK9/IRS2/RRAS/PIK3CB/PIK3R2/MAP2K2/IRS1/PRKAA1/PDPK1/AKT2/PIK3CA/RRAGD/MRAS/RAB39B/RRAGB/RRAS2/PRKAA2/RRAGC/TBK1/BNIP3/LAMP1/RUBCN/VAMP8/PIK3R1/ITPR1/DDIT4/MTMR14/DEPTOR/AKT1S1/TANK/IRS4/EIF2S1/NRBF2	88	http://www.kegg.jp/kegg-bin/show_pathway?hsa04140/AKT3/ATG7/MAPK3/PRKACB/KRAS/BCL2/CTSB/MTOR/MAPK1/AKT1/PTEN/VMP1/BCL2L1/MAP2K1/STK11/HIF1A/RAB1A/GABARAPL1/BECN1/RB1CC1/PIK3C3/GABARAP/ATG9A/ULK1/SH3GLB1/TP53INP2/MTMR3/WIPI2/ATG12/ATG14/ATG2A/RAB33B/AMBRA1/STX17/SMCR8/ATG2B/ULK2/EIF2AK4/HRAS/RPS6KB1/HMGB1/MAPK10/TRAF6/SQSTM1/SUPT20H/MAP3K7/NRAS/RAB8A/DAPK1/UVRAG/PPP2CB/MAPK8/IGF1R/CAMKK2/PRKCD/MAPK9/IRS2/RRAS/PIK3CB/PIK3R2/MAP2K2/IRS1/PRKAA1/PDPK1/AKT2/PIK3CA/RRAGD/MRAS/RAB39B/RRAGB/RRAS2/PRKAA2/RRAGC/TBK1/BNIP3/LAMP1/RUBCN/VAMP8/PIK3R1/ITPR1/DDIT4/MTMR14/DEPTOR/AKT1S1/TANK/IRS4/EIF2S1/NRBF2
hsa05224	Breast cancer	93/3197	147/8019	6.42851019631765e-09	9.88766092100286e-08	5.76793646687148e-08	TP53/AKT3/MAPK3/CCND1/BAK1/WNT9B/KRAS/FZD5/EGFR/LEF1/HEY1/GRB2/CTNNB1/E2F1/ESR1/MTOR/MAPK1/SOS1/AKT1/WNT5A/KIT/LRP6/PTEN/FZD4/MAP2K1/WNT7A/BAX/IGF1/NOTCH1/HES1/WNT4/HEY2/JAG2/WNT7B/FOS/RB1/APC/HRAS/GADD45A/CDKN1A/CDK4/MYC/RPS6KB1/CDK6/TCF7L2/JUN/NOTCH3/ESR2/E2F2/FGFR1/FZD8/HEYL/E2F3/DLL4/NOTCH2/NRAS/BRAF/WNT16/IGF1R/ERBB2/DVL3/FGF19/SHC3/FGF2/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/DVL2/FGF23/FZD7/AKT2/PIK3CA/CSNK1A1/GSK3B/APC2/NCOA3/SP1/LRP5/SOS2/AXIN2/PIK3R1/NFKB2/WNT8B/FZD9/FZD1/JAG1/WNT10A/FZD6/FZD2/SHC4/FRAT2	93	http://www.kegg.jp/kegg-bin/show_pathway?hsa05224/TP53/AKT3/MAPK3/CCND1/BAK1/WNT9B/KRAS/FZD5/EGFR/LEF1/HEY1/GRB2/CTNNB1/E2F1/ESR1/MTOR/MAPK1/SOS1/AKT1/WNT5A/KIT/LRP6/PTEN/FZD4/MAP2K1/WNT7A/BAX/IGF1/NOTCH1/HES1/WNT4/HEY2/JAG2/WNT7B/FOS/RB1/APC/HRAS/GADD45A/CDKN1A/CDK4/MYC/RPS6KB1/CDK6/TCF7L2/JUN/NOTCH3/ESR2/E2F2/FGFR1/FZD8/HEYL/E2F3/DLL4/NOTCH2/NRAS/BRAF/WNT16/IGF1R/ERBB2/DVL3/FGF19/SHC3/FGF2/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/DVL2/FGF23/FZD7/AKT2/PIK3CA/CSNK1A1/GSK3B/APC2/NCOA3/SP1/LRP5/SOS2/AXIN2/PIK3R1/NFKB2/WNT8B/FZD9/FZD1/JAG1/WNT10A/FZD6/FZD2/SHC4/FRAT2
hsa04390	Hippo signaling pathway	98/3197	157/8019	7.08426155154702e-09	1.03598025326978e-07	6.04335881816168e-08	CCND1/TGFB2/WNT9B/TGFBR1/FZD5/LEF1/CTNNA1/CTNNB1/SMAD4/WNT5A/TGFBR2/GLI2/BMPR2/FZD4/WNT7A/BMP7/STK3/PPP2R1A/BIRC3/BIRC2/WNT4/TGFB1/WNT7B/BMPR1A/AMH/APC/ACTB/CCND3/CCND2/LATS2/MYC/ID2/YWHAE/CSNK1E/FBXW11/CSNK1D/BTRC/PPP2R2A/PPP1CB/YWHAG/TCF7L2/SMAD3/BMP2/SMAD2/SMAD7/FZD8/WWC1/SOX2/WWTR1/SNAI2/ID1/PPP2R2D/PPP2R1B/NKD1/PPP2CB/PPP1CC/WNT16/YWHAB/NF2/DVL3/BMP8A/DLG3/DLG4/DVL2/BMP8B/FZD7/ACTG1/GSK3B/BIRC5/APC2/PARD6B/PARD3/BBC3/AXIN2/CDH1/YAP1/YWHAH/FRMD6/WTIP/LIMD1/TEAD1/WNT8B/SERPINE1/FZD9/FZD1/CTNNA3/AMOT/DLG5/WNT10A/FZD6/FZD2/YWHAZ/TP53BP2/YWHAQ/MOB1B/MPP5/MOB1A/PATJ	98	http://www.kegg.jp/kegg-bin/show_pathway?hsa04390/CCND1/TGFB2/WNT9B/TGFBR1/FZD5/LEF1/CTNNA1/CTNNB1/SMAD4/WNT5A/TGFBR2/GLI2/BMPR2/FZD4/WNT7A/BMP7/STK3/PPP2R1A/BIRC3/BIRC2/WNT4/TGFB1/WNT7B/BMPR1A/AMH/APC/ACTB/CCND3/CCND2/LATS2/MYC/ID2/YWHAE/CSNK1E/FBXW11/CSNK1D/BTRC/PPP2R2A/PPP1CB/YWHAG/TCF7L2/SMAD3/BMP2/SMAD2/SMAD7/FZD8/WWC1/SOX2/WWTR1/SNAI2/ID1/PPP2R2D/PPP2R1B/NKD1/PPP2CB/PPP1CC/WNT16/YWHAB/NF2/DVL3/BMP8A/DLG3/DLG4/DVL2/BMP8B/FZD7/ACTG1/GSK3B/BIRC5/APC2/PARD6B/PARD3/BBC3/AXIN2/CDH1/YAP1/YWHAH/FRMD6/WTIP/LIMD1/TEAD1/WNT8B/SERPINE1/FZD9/FZD1/CTNNA3/AMOT/DLG5/WNT10A/FZD6/FZD2/YWHAZ/TP53BP2/YWHAQ/MOB1B/MPP5/MOB1A/PATJ
hsa05165	Human papillomavirus infection	182/3197	330/8019	7.37694917189009e-09	1.03598025326978e-07	6.04335881816168e-08	TP53/AKT3/MAPK3/CCND1/BAK1/WNT9B/PRKACB/KRAS/FZD5/VEGFA/EGFR/PTGS2/HEY1/GRB2/CTNNB1/CASP8/E2F1/MTOR/UBE3A/MAPK1/SOS1/AKT1/CCNE2/WNT5A/CCNE1/TUBG1/PTEN/ITGA5/FZD4/MAP2K1/WNT7A/CDK2/ITGB1/ATM/PPP2R1A/BAX/PDGFRB/TBP/ITGB8/NOTCH1/CDKN1B/TNC/HES1/ITGA3/ITGA2/WNT4/CASP3/HEY2/TBPL1/WNT7B/HDAC2/RBPJ/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/PSEN1/TERT/RB1/APC/HRAS/EP300/MDM2/CDKN1A/CCND3/CCNA2/CCND2/CDK4/RBL1/RPS6KB1/EIF4EBP1/CDK6/PPP2R2A/HDAC1/CHD4/TCF7L2/TNF/FOXO1/HES7/STAT1/NOTCH3/HES2/FZD8/CREBBP/NFX1/HEYL/TBPL2/HLA-A/HLA-B/HLA-C/HLA-E/CDC42/CREB3/NOTCH2/NRAS/IKBKG/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/WNT16/DVL3/FAS/ITGA1/THBS1/FN1/DLG3/EIF2AK2/PIK3CB/PIK3R2/MAP2K2/DVL2/FZD7/GNAS/AKT2/PIK3CA/CSNK1A1/PKM/MX1/GSK3B/TBK1/APC2/PARD6B/PARD3/PPP2R3C/CREB1/IRF1/STAT2/PXN/COL1A1/COL6A1/IFNAR1/SOS2/CREB3L2/AXIN2/LAMA2/ITGA7/PIK3R1/TNR/LAMC1/COL4A4/ITGA8/ITGB3/RBPJL/CREB5/COL1A2/COL4A1/WNT8B/COL9A2/ITGA11/FZD9/FZD1/JAG1/TICAM1/THBS2/COL4A2/ITGB4/LAMA4/WNT10A/FZD6/FZD2/IFNB1/UBR4/TRAF3/TRADD/IFNAR2/MPP5/MAML1/ITGA9/COL4A5/MAML3/PATJ	182	http://www.kegg.jp/kegg-bin/show_pathway?hsa05165/TP53/AKT3/MAPK3/CCND1/BAK1/WNT9B/PRKACB/KRAS/FZD5/VEGFA/EGFR/PTGS2/HEY1/GRB2/CTNNB1/CASP8/E2F1/MTOR/UBE3A/MAPK1/SOS1/AKT1/CCNE2/WNT5A/CCNE1/TUBG1/PTEN/ITGA5/FZD4/MAP2K1/WNT7A/CDK2/ITGB1/ATM/PPP2R1A/BAX/PDGFRB/TBP/ITGB8/NOTCH1/CDKN1B/TNC/HES1/ITGA3/ITGA2/WNT4/CASP3/HEY2/TBPL1/WNT7B/HDAC2/RBPJ/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/PSEN1/TERT/RB1/APC/HRAS/EP300/MDM2/CDKN1A/CCND3/CCNA2/CCND2/CDK4/RBL1/RPS6KB1/EIF4EBP1/CDK6/PPP2R2A/HDAC1/CHD4/TCF7L2/TNF/FOXO1/HES7/STAT1/NOTCH3/HES2/FZD8/CREBBP/NFX1/HEYL/TBPL2/HLA-A/HLA-B/HLA-C/HLA-E/CDC42/CREB3/NOTCH2/NRAS/IKBKG/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/WNT16/DVL3/FAS/ITGA1/THBS1/FN1/DLG3/EIF2AK2/PIK3CB/PIK3R2/MAP2K2/DVL2/FZD7/GNAS/AKT2/PIK3CA/CSNK1A1/PKM/MX1/GSK3B/TBK1/APC2/PARD6B/PARD3/PPP2R3C/CREB1/IRF1/STAT2/PXN/COL1A1/COL6A1/IFNAR1/SOS2/CREB3L2/AXIN2/LAMA2/ITGA7/PIK3R1/TNR/LAMC1/COL4A4/ITGA8/ITGB3/RBPJL/CREB5/COL1A2/COL4A1/WNT8B/COL9A2/ITGA11/FZD9/FZD1/JAG1/TICAM1/THBS2/COL4A2/ITGB4/LAMA4/WNT10A/FZD6/FZD2/IFNB1/UBR4/TRAF3/TRADD/IFNAR2/MPP5/MAML1/ITGA9/COL4A5/MAML3/PATJ
hsa04012	ErbB signaling pathway	60/3197	85/8019	8.15504304957053e-09	1.09753287708803e-07	6.40242414856634e-08	AKT3/MAPK3/KRAS/EGFR/GRB2/MTOR/MAPK1/SOS1/AKT1/CRKL/MAP2K1/SRC/EREG/CDKN1B/HRAS/CDKN1A/MYC/CAMK2A/RPS6KB1/EIF4EBP1/MAPK10/JUN/NCK2/NRAS/TGFA/ABL1/BRAF/MAP2K4/PAK3/MAPK8/PAK2/ERBB2/PAK4/PAK1/ERBB3/NRG4/MAPK9/MAP2K7/SHC3/ERBB4/CRK/PIK3CB/PRKCA/PIK3R2/MAP2K2/HBEGF/AKT2/PRKCB/PIK3CA/CAMK2G/ABL2/GSK3B/SOS2/PLCG1/PIK3R1/ELK1/STAT5A/PLCG2/CBLB/SHC4	60	http://www.kegg.jp/kegg-bin/show_pathway?hsa04012/AKT3/MAPK3/KRAS/EGFR/GRB2/MTOR/MAPK1/SOS1/AKT1/CRKL/MAP2K1/SRC/EREG/CDKN1B/HRAS/CDKN1A/MYC/CAMK2A/RPS6KB1/EIF4EBP1/MAPK10/JUN/NCK2/NRAS/TGFA/ABL1/BRAF/MAP2K4/PAK3/MAPK8/PAK2/ERBB2/PAK4/PAK1/ERBB3/NRG4/MAPK9/MAP2K7/SHC3/ERBB4/CRK/PIK3CB/PRKCA/PIK3R2/MAP2K2/HBEGF/AKT2/PRKCB/PIK3CA/CAMK2G/ABL2/GSK3B/SOS2/PLCG1/PIK3R1/ELK1/STAT5A/PLCG2/CBLB/SHC4
hsa04810	Regulation of actin cytoskeleton	125/3197	213/8019	1.5013953577532e-08	1.90181689581073e-07	1.10941901368786e-07	MAPK3/MYH9/KRAS/EGFR/PDGFRA/MAPK1/SOS1/PDGFB/ITGA5/CRKL/MAP2K1/SRC/ITGB1/PDGFRB/ITGB8/ITGA3/ITGA2/DIAPH2/PIP4K2C/PIKFYVE/APC/HRAS/ACTB/RDX/PPP1R12B/PPP1R12A/PPP1CB/ARHGAP35/FGFR1/EZR/RAC1/CDC42/NRAS/ROCK1/PDGFA/PDGFD/PDGFC/MYH14/WASL/PPP1CC/BRAF/PAK3/PAK2/ROCK2/PAK4/PAK1/FGF19/ARHGEF6/ITGA1/CXCR4/RRAS/IQGAP1/FN1/CRK/FGF2/FGF5/PIK3CB/PIK3R2/MAP2K2/FGFR3/FGF7/TIAM1/FGF23/FGFR4/GNA12/PIP5K1A/RHOA/PIK3CA/MRAS/GNA13/MYLK3/ACTG1/RRAS2/PFN1/LIMK1/MYLK4/APC2/PXN/SOS2/ITGA7/DIAPH1/VCL/CYFIP2/PIK3R1/DOCK1/SSH2/SSH1/CXCL12/ACTN4/ABI2/BAIAP2/ITGA8/ENAH/ARPC2/ITGB3/WASF2/ACTN1/MSN/F2/NCKAP1/GSN/ITGA11/PFN2/CHRM2/VAV2/VAV3/ITGAX/BCAR1/BDKRB2/ITGB4/TMSB4X/SPATA13/MYL12A/IQGAP2/ARPC5/GNG12/ARPC1B/ARPC4/ITGA9/CHRM3/ARPC5L/LPAR2/CFL2/PPP1R12C/PFN4	125	http://www.kegg.jp/kegg-bin/show_pathway?hsa04810/MAPK3/MYH9/KRAS/EGFR/PDGFRA/MAPK1/SOS1/PDGFB/ITGA5/CRKL/MAP2K1/SRC/ITGB1/PDGFRB/ITGB8/ITGA3/ITGA2/DIAPH2/PIP4K2C/PIKFYVE/APC/HRAS/ACTB/RDX/PPP1R12B/PPP1R12A/PPP1CB/ARHGAP35/FGFR1/EZR/RAC1/CDC42/NRAS/ROCK1/PDGFA/PDGFD/PDGFC/MYH14/WASL/PPP1CC/BRAF/PAK3/PAK2/ROCK2/PAK4/PAK1/FGF19/ARHGEF6/ITGA1/CXCR4/RRAS/IQGAP1/FN1/CRK/FGF2/FGF5/PIK3CB/PIK3R2/MAP2K2/FGFR3/FGF7/TIAM1/FGF23/FGFR4/GNA12/PIP5K1A/RHOA/PIK3CA/MRAS/GNA13/MYLK3/ACTG1/RRAS2/PFN1/LIMK1/MYLK4/APC2/PXN/SOS2/ITGA7/DIAPH1/VCL/CYFIP2/PIK3R1/DOCK1/SSH2/SSH1/CXCL12/ACTN4/ABI2/BAIAP2/ITGA8/ENAH/ARPC2/ITGB3/WASF2/ACTN1/MSN/F2/NCKAP1/GSN/ITGA11/PFN2/CHRM2/VAV2/VAV3/ITGAX/BCAR1/BDKRB2/ITGB4/TMSB4X/SPATA13/MYL12A/IQGAP2/ARPC5/GNG12/ARPC1B/ARPC4/ITGA9/CHRM3/ARPC5L/LPAR2/CFL2/PPP1R12C/PFN4
hsa04668	TNF signaling pathway	74/3197	112/8019	1.53087428145756e-08	1.90181689581073e-07	1.10941901368786e-07	AKT3/MAPK14/MAPK3/IL1B/PTGS2/CASP8/MAPK1/AKT1/SOCS3/CSF1/ICAM1/EDN1/MAP2K6/MAP2K1/LIF/BIRC3/JUNB/MMP9/BIRC2/CASP3/FOS/CEBPB/MMP14/ATF2/TNFAIP3/CCL2/TNF/MAPK10/JUN/MAP3K7/CREB3/DNM1L/IKBKG/MAP2K4/MAPK8/CCL5/MAP3K8/FAS/MAPK9/MAP2K7/TAB2/PIK3CB/MAP3K5/PIK3R2/TAB1/MAP2K3/ITCH/AKT2/PIK3CA/RPS6KA4/RPS6KA5/CREB1/IRF1/CXCL10/CREB3L2/PIK3R1/ATF6B/ATF4/CREB5/JAG1/BCL3/PGAM5/CXCL5/CXCL1/CXCL3/VCAM1/BAG4/IFNB1/TNFRSF1B/TRAF3/TRADD/TRAF1/SELE/CASP7	74	http://www.kegg.jp/kegg-bin/show_pathway?hsa04668/AKT3/MAPK14/MAPK3/IL1B/PTGS2/CASP8/MAPK1/AKT1/SOCS3/CSF1/ICAM1/EDN1/MAP2K6/MAP2K1/LIF/BIRC3/JUNB/MMP9/BIRC2/CASP3/FOS/CEBPB/MMP14/ATF2/TNFAIP3/CCL2/TNF/MAPK10/JUN/MAP3K7/CREB3/DNM1L/IKBKG/MAP2K4/MAPK8/CCL5/MAP3K8/FAS/MAPK9/MAP2K7/TAB2/PIK3CB/MAP3K5/PIK3R2/TAB1/MAP2K3/ITCH/AKT2/PIK3CA/RPS6KA4/RPS6KA5/CREB1/IRF1/CXCL10/CREB3L2/PIK3R1/ATF6B/ATF4/CREB5/JAG1/BCL3/PGAM5/CXCL5/CXCL1/CXCL3/VCAM1/BAG4/IFNB1/TNFRSF1B/TRAF3/TRADD/TRAF1/SELE/CASP7
hsa05213	Endometrial cancer	44/3197	58/8019	2.45530885845129e-08	2.93727689362877e-07	1.71345140609271e-07	TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/LEF1/CTNNA1/FOXO3/GRB2/CTNNB1/MAPK1/SOS1/AKT1/PTEN/MLH1/MAP2K1/BAX/APC/HRAS/GADD45A/CDKN1A/MYC/TCF7L2/NRAS/BRAF/ERBB2/PIK3CB/PIK3R2/MAP2K2/ILK/PDPK1/AKT2/PIK3CA/GSK3B/APC2/SOS2/AXIN2/CDH1/PIK3R1/CASP9/ELK1/CTNNA3	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa05213/TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/LEF1/CTNNA1/FOXO3/GRB2/CTNNB1/MAPK1/SOS1/AKT1/PTEN/MLH1/MAP2K1/BAX/APC/HRAS/GADD45A/CDKN1A/MYC/TCF7L2/NRAS/BRAF/ERBB2/PIK3CB/PIK3R2/MAP2K2/ILK/PDPK1/AKT2/PIK3CA/GSK3B/APC2/SOS2/AXIN2/CDH1/PIK3R1/CASP9/ELK1/CTNNA3
hsa04550	Signaling pathways regulating pluripotency of stem cells	89/3197	142/8019	2.62690721762521e-08	3.03032511176051e-07	1.76773079682298e-07	AKT3/MAPK14/MAPK3/WNT9B/KRAS/FZD5/GRB2/CTNNB1/MAPK1/AKT1/SMAD4/WNT5A/ACVR1B/ID4/BMPR2/INHBA/FZD4/MAP2K1/WNT7A/LIF/TBX3/IGF1/ACVR1/HAND1/SKIL/SMAD5/WNT4/WNT7B/STAT3/NODAL/BMPR1A/RIF1/APC/HRAS/MYC/KLF4/ID2/SMAD3/POU5F1/TCF3/SMAD2/ZFHX3/ACVR2B/FGFR1/FZD8/JARID2/SOX2/BMI1/REST/ID1/LEFTY1/KAT6A/NRAS/PCGF3/PCGF5/WNT16/IGF1R/DVL3/FGF2/PIK3CB/JAK2/PIK3R2/MAP2K2/FGFR3/DVL2/FZD7/FGFR4/AKT2/PIK3CA/GSK3B/APC2/AXIN2/PIK3R1/MEIS1/OTX1/NANOG/LHX5/POU5F1B/HOXA1/ONECUT1/WNT8B/FZD9/FZD1/IL6ST/WNT10A/FZD6/FZD2/LIFR/COMMD3-BMI1	89	http://www.kegg.jp/kegg-bin/show_pathway?hsa04550/AKT3/MAPK14/MAPK3/WNT9B/KRAS/FZD5/GRB2/CTNNB1/MAPK1/AKT1/SMAD4/WNT5A/ACVR1B/ID4/BMPR2/INHBA/FZD4/MAP2K1/WNT7A/LIF/TBX3/IGF1/ACVR1/HAND1/SKIL/SMAD5/WNT4/WNT7B/STAT3/NODAL/BMPR1A/RIF1/APC/HRAS/MYC/KLF4/ID2/SMAD3/POU5F1/TCF3/SMAD2/ZFHX3/ACVR2B/FGFR1/FZD8/JARID2/SOX2/BMI1/REST/ID1/LEFTY1/KAT6A/NRAS/PCGF3/PCGF5/WNT16/IGF1R/DVL3/FGF2/PIK3CB/JAK2/PIK3R2/MAP2K2/FGFR3/DVL2/FZD7/FGFR4/AKT2/PIK3CA/GSK3B/APC2/AXIN2/PIK3R1/MEIS1/OTX1/NANOG/LHX5/POU5F1B/HOXA1/ONECUT1/WNT8B/FZD9/FZD1/IL6ST/WNT10A/FZD6/FZD2/LIFR/COMMD3-BMI1
hsa05220	Chronic myeloid leukemia	54/3197	76/8019	3.18033201190136e-08	3.54223186153151e-07	2.06635001862194e-07	TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/GRB2/E2F1/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/CRKL/BCL2L1/MAP2K1/BAX/CDKN1B/PTPN11/TGFB1/HDAC2/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/MYC/CDK6/HDAC1/CTBP1/SMAD3/RUNX1/E2F2/E2F3/NRAS/ABL1/IKBKG/BRAF/SHC3/CRK/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/SOS2/PIK3R1/GAB2/STAT5A/SHC4	54	http://www.kegg.jp/kegg-bin/show_pathway?hsa05220/TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/GRB2/E2F1/MAPK1/SOS1/AKT1/SMAD4/TGFBR2/CRKL/BCL2L1/MAP2K1/BAX/CDKN1B/PTPN11/TGFB1/HDAC2/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/MYC/CDK6/HDAC1/CTBP1/SMAD3/RUNX1/E2F2/E2F3/NRAS/ABL1/IKBKG/BRAF/SHC3/CRK/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/SOS2/PIK3R1/GAB2/STAT5A/SHC4
hsa05226	Gastric cancer	92/3197	149/8019	4.39882368672131e-08	4.73606683603661e-07	2.76276996464251e-07	TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/WNT9B/TGFBR1/KRAS/FZD5/EGFR/LEF1/BCL2/CTNNA1/GRB2/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/SMAD4/CCNE2/WNT5A/TGFBR2/LRP6/CCNE1/RXRA/MLH1/FZD4/MAP2K1/WNT7A/CDK2/CDX2/BAX/CDKN1B/WNT4/TGFB1/WNT7B/TERT/RB1/APC/HRAS/GADD45A/CDKN1A/CDKN2B/MYC/RPS6KB1/TCF7L2/SMAD3/SMAD2/E2F2/FZD8/E2F3/NRAS/BRAF/WNT16/ERBB2/DVL3/FGF19/SHC3/FGF2/MET/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/DVL2/FGF23/FZD7/HGF/AKT2/PIK3CA/CSNK1A1/GSK3B/APC2/LRP5/SOS2/AXIN2/CDH1/PIK3R1/WNT8B/FZD9/FZD1/CTNNA3/JUP/WNT10A/FZD6/FZD2/SHC4/FRAT2	92	http://www.kegg.jp/kegg-bin/show_pathway?hsa05226/TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/WNT9B/TGFBR1/KRAS/FZD5/EGFR/LEF1/BCL2/CTNNA1/GRB2/CTNNB1/E2F1/MTOR/MAPK1/SOS1/AKT1/SMAD4/CCNE2/WNT5A/TGFBR2/LRP6/CCNE1/RXRA/MLH1/FZD4/MAP2K1/WNT7A/CDK2/CDX2/BAX/CDKN1B/WNT4/TGFB1/WNT7B/TERT/RB1/APC/HRAS/GADD45A/CDKN1A/CDKN2B/MYC/RPS6KB1/TCF7L2/SMAD3/SMAD2/E2F2/FZD8/E2F3/NRAS/BRAF/WNT16/ERBB2/DVL3/FGF19/SHC3/FGF2/MET/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/DVL2/FGF23/FZD7/HGF/AKT2/PIK3CA/CSNK1A1/GSK3B/APC2/LRP5/SOS2/AXIN2/CDH1/PIK3R1/WNT8B/FZD9/FZD1/CTNNA3/JUP/WNT10A/FZD6/FZD2/SHC4/FRAT2
hsa05219	Bladder cancer	33/3197	41/8019	1.18718474573308e-07	1.23696991248963e-06	7.2158257890058e-07	TP53/MAPK3/CCND1/KRAS/VEGFA/EGFR/MMP2/E2F1/MAPK1/MAP2K1/SRC/MMP9/RB1/HRAS/MDM2/CDKN1A/CDKN2A/CDK4/MYC/E2F2/E2F3/NRAS/DAPK1/BRAF/ERBB2/THBS1/MAP2K2/FGFR3/HBEGF/RPS6KA5/CDH1/CXCL8/MMP1	33	http://www.kegg.jp/kegg-bin/show_pathway?hsa05219/TP53/MAPK3/CCND1/KRAS/VEGFA/EGFR/MMP2/E2F1/MAPK1/MAP2K1/SRC/MMP9/RB1/HRAS/MDM2/CDKN1A/CDKN2A/CDK4/MYC/E2F2/E2F3/NRAS/DAPK1/BRAF/ERBB2/THBS1/MAP2K2/FGFR3/HBEGF/RPS6KA5/CDH1/CXCL8/MMP1
hsa05230	Central carbon metabolism in cancer	49/3197	69/8019	1.42549000067575e-07	1.42814463681621e-06	8.3310376402184e-07	TP53/AKT3/MAPK3/KRAS/EGFR/PDGFRA/MTOR/MAPK1/AKT1/KIT/PTEN/SLC2A1/MAP2K1/PDGFRB/HIF1A/SCO2/HRAS/MYC/FGFR1/NRAS/ERBB2/NTRK3/MET/PIK3CB/PIK3R2/MAP2K2/FGFR3/SIRT3/HK1/AKT2/PFKP/LDHA/PIK3CA/PDK1/PFKM/LDHB/G6PD/GCK/PKM/HK2/TIGAR/PIK3R1/SLC1A5/PGAM1/SLC7A5/SLC16A3/PDHA1/PDHB/PGAM4	49	http://www.kegg.jp/kegg-bin/show_pathway?hsa05230/TP53/AKT3/MAPK3/KRAS/EGFR/PDGFRA/MTOR/MAPK1/AKT1/KIT/PTEN/SLC2A1/MAP2K1/PDGFRB/HIF1A/SCO2/HRAS/MYC/FGFR1/NRAS/ERBB2/NTRK3/MET/PIK3CB/PIK3R2/MAP2K2/FGFR3/SIRT3/HK1/AKT2/PFKP/LDHA/PIK3CA/PDK1/PFKM/LDHB/G6PD/GCK/PKM/HK2/TIGAR/PIK3R1/SLC1A5/PGAM1/SLC7A5/SLC16A3/PDHA1/PDHB/PGAM4
hsa05135	Yersinia infection	76/3197	120/8019	1.45909513978127e-07	1.42814463681621e-06	8.3310376402184e-07	AKT3/MAPK14/MAPK3/IL1B/MAPK1/AKT1/ITGA5/CRKL/MAP2K6/MAP2K1/SRC/ITGB1/ACTR2/FOS/ACTB/CCL2/TNF/MAPK10/TRAF6/NFATC2/JUN/NFATC3/MAP3K7/RAC1/NLRP3/CDC42/PYCARD/ROCK1/WASL/WIPF2/IKBKG/MAP2K4/MAPK8/ROCK2/IRAK4/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/FN1/CRK/PIK3CB/PIK3R2/MAP2K2/TAB1/MAP2K3/IL18/PIP5K1A/AKT2/RPS6KA2/RHOA/PIK3CA/ARF6/RPS6KA3/ACTG1/GSK3B/ACTR3B/LIMK1/TBK1/NFATC1/PXN/PLCG1/PIK3R1/DOCK1/BAIAP2/WASF2/TICAM1/CXCL8/VAV2/VAV3/BCAR1/IFNB1/SKAP2/FYB1/GIT2	76	http://www.kegg.jp/kegg-bin/show_pathway?hsa05135/AKT3/MAPK14/MAPK3/IL1B/MAPK1/AKT1/ITGA5/CRKL/MAP2K6/MAP2K1/SRC/ITGB1/ACTR2/FOS/ACTB/CCL2/TNF/MAPK10/TRAF6/NFATC2/JUN/NFATC3/MAP3K7/RAC1/NLRP3/CDC42/PYCARD/ROCK1/WASL/WIPF2/IKBKG/MAP2K4/MAPK8/ROCK2/IRAK4/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/FN1/CRK/PIK3CB/PIK3R2/MAP2K2/TAB1/MAP2K3/IL18/PIP5K1A/AKT2/RPS6KA2/RHOA/PIK3CA/ARF6/RPS6KA3/ACTG1/GSK3B/ACTR3B/LIMK1/TBK1/NFATC1/PXN/PLCG1/PIK3R1/DOCK1/BAIAP2/WASF2/TICAM1/CXCL8/VAV2/VAV3/BCAR1/IFNB1/SKAP2/FYB1/GIT2
hsa05131	Shigellosis	133/3197	236/8019	1.53541675379264e-07	1.45864591610301e-06	8.50896591111092e-07	TP53/AKT3/MAPK14/UBB/MAPK3/IL1B/EGFR/BCL2/FOXO3/MTOR/MAPK1/AKT1/ITGA5/CRKL/BCL2L1/PLCD1/SRC/ITGB1/ATM/BAX/GJA1/PLCD3/GABARAPL1/BECN1/PIK3C3/GABARAP/WIPI2/ATG12/ATG14/MDM2/FOXO4/ACTB/CUL1/RPS6KB1/FBXW11/BTRC/SKP1/RBX1/TNF/MAPK10/FOXO1/TRAF6/UBE2D1/JUN/FOXO6/SQSTM1/UBE2D3/MAP3K7/ARHGEF2/RAC1/NLRP3/CDC42/PYCARD/ROCK1/ARF1/PLCE1/WASL/ABL1/UBE2D4/UBE2D2/IKBKG/UBE2V1/UBE2N/CYCS/MAPK8/ROCK2/CCL5/PRKCD/MAPK9/TLR4/TAB2/CRK/TNIP1/PIK3CB/PIK3R2/TAB1/CD44/IL18/ILK/HK1/NAIP/AKT2/RHOA/PIK3CA/RRAGD/RRAGB/RPS6KA5/ACTG1/GSK3B/HK2/RRAGC/PFN1/TBK1/UBE2V2/CBX3/BNIP3/PXN/CAPN1/C3/FNBP1/TECPR1/BCL10/CALCOCO2/VDAC1/PLCG1/DIAPH1/VCL/PIK3R1/DOCK1/ACTN4/ARPC2/WASF2/ACTN1/PFN2/CXCL8/MALT1/ITPR2/ITPR1/TLN1/PLCG2/IFNB1/MYL12A/ARPC5/TLR5/AKT1S1/TRADD/CAST/ARPC1B/ARPC4/FNBP1L/ARPC5L/CAPNS1/PFN4	133	http://www.kegg.jp/kegg-bin/show_pathway?hsa05131/TP53/AKT3/MAPK14/UBB/MAPK3/IL1B/EGFR/BCL2/FOXO3/MTOR/MAPK1/AKT1/ITGA5/CRKL/BCL2L1/PLCD1/SRC/ITGB1/ATM/BAX/GJA1/PLCD3/GABARAPL1/BECN1/PIK3C3/GABARAP/WIPI2/ATG12/ATG14/MDM2/FOXO4/ACTB/CUL1/RPS6KB1/FBXW11/BTRC/SKP1/RBX1/TNF/MAPK10/FOXO1/TRAF6/UBE2D1/JUN/FOXO6/SQSTM1/UBE2D3/MAP3K7/ARHGEF2/RAC1/NLRP3/CDC42/PYCARD/ROCK1/ARF1/PLCE1/WASL/ABL1/UBE2D4/UBE2D2/IKBKG/UBE2V1/UBE2N/CYCS/MAPK8/ROCK2/CCL5/PRKCD/MAPK9/TLR4/TAB2/CRK/TNIP1/PIK3CB/PIK3R2/TAB1/CD44/IL18/ILK/HK1/NAIP/AKT2/RHOA/PIK3CA/RRAGD/RRAGB/RPS6KA5/ACTG1/GSK3B/HK2/RRAGC/PFN1/TBK1/UBE2V2/CBX3/BNIP3/PXN/CAPN1/C3/FNBP1/TECPR1/BCL10/CALCOCO2/VDAC1/PLCG1/DIAPH1/VCL/PIK3R1/DOCK1/ACTN4/ARPC2/WASF2/ACTN1/PFN2/CXCL8/MALT1/ITPR2/ITPR1/TLN1/PLCG2/IFNB1/MYL12A/ARPC5/TLR5/AKT1S1/TRADD/CAST/ARPC1B/ARPC4/FNBP1L/ARPC5L/CAPNS1/PFN4
hsa01524	Platinum drug resistance	51/3197	73/8019	1.8451393339815e-07	1.7028000139315e-06	9.93323130173499e-07	TP53/AKT3/MAPK3/BAK1/BCL2/CASP8/MAPK1/AKT1/BCL2L1/MLH1/MSH2/ATM/BAX/MSH6/ERCC1/BIRC3/MSH3/BIRC2/CASP3/ATP7A/SLC31A1/ATP7B/MDM2/CDKN1A/CDKN2A/BID/XPA/CYCS/ERBB2/FAS/PIK3CB/MAP3K5/PIK3R2/GSTP1/PDPK1/AKT2/PIK3CA/REV3L/APAF1/XIAP/BIRC5/BBC3/POLH/PIK3R1/CASP9/PMAIP1/GSTM4/GSTM3/GSTO1/MGST3/GSTO2	51	http://www.kegg.jp/kegg-bin/show_pathway?hsa01524/TP53/AKT3/MAPK3/BAK1/BCL2/CASP8/MAPK1/AKT1/BCL2L1/MLH1/MSH2/ATM/BAX/MSH6/ERCC1/BIRC3/MSH3/BIRC2/CASP3/ATP7A/SLC31A1/ATP7B/MDM2/CDKN1A/CDKN2A/BID/XPA/CYCS/ERBB2/FAS/PIK3CB/MAP3K5/PIK3R2/GSTP1/PDPK1/AKT2/PIK3CA/REV3L/APAF1/XIAP/BIRC5/BBC3/POLH/PIK3R1/CASP9/PMAIP1/GSTM4/GSTM3/GSTO1/MGST3/GSTO2
hsa05223	Non-small cell lung cancer	47/3197	66/8019	2.24299780665346e-07	2.01246747652519e-06	1.17396668827769e-06	TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/FOXO3/GRB2/E2F1/MAPK1/SOS1/AKT1/RXRA/MAP2K1/BAX/STK4/STAT3/RB1/HRAS/GADD45A/CDKN1A/CDKN2A/CDK4/CDK6/E2F2/E2F3/NRAS/TGFA/BRAF/ERBB2/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/AKT2/PRKCB/PIK3CA/FHIT/SOS2/PLCG1/PIK3R1/CASP9/STAT5A/PLCG2/RASSF5	47	http://www.kegg.jp/kegg-bin/show_pathway?hsa05223/TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/FOXO3/GRB2/E2F1/MAPK1/SOS1/AKT1/RXRA/MAP2K1/BAX/STK4/STAT3/RB1/HRAS/GADD45A/CDKN1A/CDKN2A/CDK4/CDK6/E2F2/E2F3/NRAS/TGFA/BRAF/ERBB2/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/AKT2/PRKCB/PIK3CA/FHIT/SOS2/PLCG1/PIK3R1/CASP9/STAT5A/PLCG2/RASSF5
hsa04150	mTOR signaling pathway	93/3197	155/8019	2.58427942058095e-07	2.25600608877743e-06	1.3160341857297e-06	AKT3/FLCN/SESN2/MAPK3/WNT9B/RPS6/KRAS/FZD5/GRB2/MTOR/MAPK1/SOS1/AKT1/WNT5A/LRP6/PTEN/FZD4/MAP2K1/WNT7A/STK11/IGF1/WNT4/WNT7B/ATP6V1B2/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V1G3/ATP6V1B1/ATP6V1G1/NPRL3/ULK1/ULK2/SEH1L/HRAS/EIF4E/RPS6KB1/EIF4EBP1/TNF/FNIP1/FZD8/NRAS/BRAF/WNT16/IGF1R/DVL3/LAMTOR1/PIK3CB/PRKCA/PIK3R2/MAP2K2/IRS1/DVL2/FZD7/PRKAA1/LAMTOR2/PDPK1/AKT2/RPS6KA2/PRKCB/RHOA/PIK3CA/RRAGD/RPS6KA3/RRAGB/SGK1/GSK3B/PRKAA2/RRAGC/RNF152/CLIP1/LRP5/LAMTOR5/SLC38A9/SOS2/PIK3R1/GRB10/CASTOR2/WNT8B/FZD9/FZD1/WNT10A/DDIT4/EIF4B/FZD6/FZD2/CAB39/MAPKAP1/DEPTOR/AKT1S1/RICTOR/SLC7A5/LPIN3	93	http://www.kegg.jp/kegg-bin/show_pathway?hsa04150/AKT3/FLCN/SESN2/MAPK3/WNT9B/RPS6/KRAS/FZD5/GRB2/MTOR/MAPK1/SOS1/AKT1/WNT5A/LRP6/PTEN/FZD4/MAP2K1/WNT7A/STK11/IGF1/WNT4/WNT7B/ATP6V1B2/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V1G3/ATP6V1B1/ATP6V1G1/NPRL3/ULK1/ULK2/SEH1L/HRAS/EIF4E/RPS6KB1/EIF4EBP1/TNF/FNIP1/FZD8/NRAS/BRAF/WNT16/IGF1R/DVL3/LAMTOR1/PIK3CB/PRKCA/PIK3R2/MAP2K2/IRS1/DVL2/FZD7/PRKAA1/LAMTOR2/PDPK1/AKT2/RPS6KA2/PRKCB/RHOA/PIK3CA/RRAGD/RPS6KA3/RRAGB/SGK1/GSK3B/PRKAA2/RRAGC/RNF152/CLIP1/LRP5/LAMTOR5/SLC38A9/SOS2/PIK3R1/GRB10/CASTOR2/WNT8B/FZD9/FZD1/WNT10A/DDIT4/EIF4B/FZD6/FZD2/CAB39/MAPKAP1/DEPTOR/AKT1S1/RICTOR/SLC7A5/LPIN3
hsa05166	Human T-cell leukemia virus 1 infection	124/3197	219/8019	2.85526016410395e-07	2.42697113948836e-06	1.41576612015127e-06	TP53/AKT3/MAPK3/CCND1/TGFB2/PRKACB/TGFBR1/KRAS/ESPL1/E2F1/MAPK1/AKT1/ETS1/SMAD4/CCNE2/VDAC2/TGFBR2/CCNE1/ICAM1/PTEN/EGR1/SLC2A1/BCL2L1/MAP2K1/CDK2/ATM/BAX/CALR/TBP/FOSL1/BUB3/TBPL1/TGFB1/FOS/CHEK1/CD40/TERT/RAN/XPO1/CDC27/CDC23/ANAPC11/RB1/MAD2L1/ANAPC1/HRAS/EP300/CDKN1A/ATF2/CHEK2/CDKN2B/CCND3/CCNA2/CDKN2A/CCND2/CDK4/MYC/PPP3CA/TNF/MAPK10/SMAD3/NFATC2/ETS2/JUN/TCF3/SMAD2/E2F2/ELK4/CREBBP/SRF/ZFP36/NFATC3/E2F3/KAT2A/TBPL2/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CREB3/NRAS/IKBKG/MAP2K4/MAPK8/NRP1/MAP3K3/MAPK9/IL2RB/IL2RA/PIK3CB/PIK3R2/MAP2K2/AKT2/ADCY9/PIK3CA/ADCY2/ADCY5/XIAP/CREB1/NFATC1/SLC25A6/HLA-DOB/VDAC1/CREB3L2/PIK3R1/EGR2/ATF6B/NFYB/ELK1/ATF4/STAT5A/NFKB2/CREB5/TLN1/CD3G/CRTC3/CD3D/TNFRSF13C/PPP3R1/CANX/CRTC1/RANBP3	124	http://www.kegg.jp/kegg-bin/show_pathway?hsa05166/TP53/AKT3/MAPK3/CCND1/TGFB2/PRKACB/TGFBR1/KRAS/ESPL1/E2F1/MAPK1/AKT1/ETS1/SMAD4/CCNE2/VDAC2/TGFBR2/CCNE1/ICAM1/PTEN/EGR1/SLC2A1/BCL2L1/MAP2K1/CDK2/ATM/BAX/CALR/TBP/FOSL1/BUB3/TBPL1/TGFB1/FOS/CHEK1/CD40/TERT/RAN/XPO1/CDC27/CDC23/ANAPC11/RB1/MAD2L1/ANAPC1/HRAS/EP300/CDKN1A/ATF2/CHEK2/CDKN2B/CCND3/CCNA2/CDKN2A/CCND2/CDK4/MYC/PPP3CA/TNF/MAPK10/SMAD3/NFATC2/ETS2/JUN/TCF3/SMAD2/E2F2/ELK4/CREBBP/SRF/ZFP36/NFATC3/E2F3/KAT2A/TBPL2/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CREB3/NRAS/IKBKG/MAP2K4/MAPK8/NRP1/MAP3K3/MAPK9/IL2RB/IL2RA/PIK3CB/PIK3R2/MAP2K2/AKT2/ADCY9/PIK3CA/ADCY2/ADCY5/XIAP/CREB1/NFATC1/SLC25A6/HLA-DOB/VDAC1/CREB3L2/PIK3R1/EGR2/ATF6B/NFYB/ELK1/ATF4/STAT5A/NFKB2/CREB5/TLN1/CD3G/CRTC3/CD3D/TNFRSF13C/PPP3R1/CANX/CRTC1/RANBP3
hsa04141	Protein processing in endoplasmic reticulum	98/3197	166/8019	3.67696192119791e-07	3.04527871935109e-06	1.77645393763677e-06	BAK1/RAD23B/BCL2/HSP90AB1/BAX/HSPA2/CALR/HSPA5/DNAJA1/UBE2J1/UBQLN4/NSFL1C/UBQLN1/EIF2AK4/FBXO6/CUL1/HSP90AA1/SKP1/RBX1/MAPK10/HSPA1A/UBE2D1/UBE2D3/PRKN/MAN1A2/SAR1B/SEC24C/SEC24D/SEC24A/LMAN1/SVIP/SEC31A/PREB/SEC23B/MAN1C1/SAR1A/SEC23A/LMAN2/SEC31B/UBE2D4/UBE2D2/SYVN1/DERL2/UBE4B/FBXO2/MAPK8/MAPK9/MAP2K7/EIF2AK2/MAP3K5/HSPA1B/HSPA8/EIF2AK1/HSPA4L/HSP90B1/SIL1/UBE2G2/HYOU1/HSPA6/DNAJA2/VCP/BAG2/PLAA/ATXN3/SELENOS/NFE2L2/CAPN1/CKAP4/RPN2/RAD23A/NPLOC4/UFD1/ATF6B/ATF4/XBP1/ATXN3L/SEC61A1/ERO1A/P4HB/DNAJC10/DAD1/SSR2/SEC63/CANX/GANAB/EIF2S1/HERPUD1/YOD1/PDIA6/RPN1/SEC61B/EDEM1/UGGT1/EDEM3/SSR1/MOGS/RNF185/SSR3	98	http://www.kegg.jp/kegg-bin/show_pathway?hsa04141/BAK1/RAD23B/BCL2/HSP90AB1/BAX/HSPA2/CALR/HSPA5/DNAJA1/UBE2J1/UBQLN4/NSFL1C/UBQLN1/EIF2AK4/FBXO6/CUL1/HSP90AA1/SKP1/RBX1/MAPK10/HSPA1A/UBE2D1/UBE2D3/PRKN/MAN1A2/SAR1B/SEC24C/SEC24D/SEC24A/LMAN1/SVIP/SEC31A/PREB/SEC23B/MAN1C1/SAR1A/SEC23A/LMAN2/SEC31B/UBE2D4/UBE2D2/SYVN1/DERL2/UBE4B/FBXO2/MAPK8/MAPK9/MAP2K7/EIF2AK2/MAP3K5/HSPA1B/HSPA8/EIF2AK1/HSPA4L/HSP90B1/SIL1/UBE2G2/HYOU1/HSPA6/DNAJA2/VCP/BAG2/PLAA/ATXN3/SELENOS/NFE2L2/CAPN1/CKAP4/RPN2/RAD23A/NPLOC4/UFD1/ATF6B/ATF4/XBP1/ATXN3L/SEC61A1/ERO1A/P4HB/DNAJC10/DAD1/SSR2/SEC63/CANX/GANAB/EIF2S1/HERPUD1/YOD1/PDIA6/RPN1/SEC61B/EDEM1/UGGT1/EDEM3/SSR1/MOGS/RNF185/SSR3
hsa04152	AMPK signaling pathway	75/3197	120/8019	3.85086996873268e-07	3.10957749975164e-06	1.81396243263987e-06	AKT3/PPARGC1A/PPARG/CCND1/SIRT1/FOXO3/MTOR/AKT1/HNF4A/CFTR/LEP/PPP2R1A/STK11/IGF1/PRKAG1/ADIPOR2/RAB11B/ULK1/CCNA2/RPS6KB1/EIF4EBP1/PPP2R2A/FOXO1/CD36/SREBF1/MAP3K7/CREB3/RAB8A/RAB14/RAB10/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/IGF1R/CAMKK2/ADIPOQ/IRS2/HMGCR/PIK3CB/PIK3R2/IRS1/PRKAA1/PDPK1/AKT2/PFKP/ACACA/EEF2K/PIK3CA/PFKFB3/PFKM/EEF2/PCK1/FASN/PRKAA2/PPP2R3C/CREB1/GYS2/G6PC/CREB3L2/PIK3R1/CREB5/CPT1A/SCD/PRKAB1/PRKAB2/CAB39/AKT1S1/IRS4/CPT1C/CPT1B/SCD5/TBC1D1	75	http://www.kegg.jp/kegg-bin/show_pathway?hsa04152/AKT3/PPARGC1A/PPARG/CCND1/SIRT1/FOXO3/MTOR/AKT1/HNF4A/CFTR/LEP/PPP2R1A/STK11/IGF1/PRKAG1/ADIPOR2/RAB11B/ULK1/CCNA2/RPS6KB1/EIF4EBP1/PPP2R2A/FOXO1/CD36/SREBF1/MAP3K7/CREB3/RAB8A/RAB14/RAB10/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/IGF1R/CAMKK2/ADIPOQ/IRS2/HMGCR/PIK3CB/PIK3R2/IRS1/PRKAA1/PDPK1/AKT2/PFKP/ACACA/EEF2K/PIK3CA/PFKFB3/PFKM/EEF2/PCK1/FASN/PRKAA2/PPP2R3C/CREB1/GYS2/G6PC/CREB3L2/PIK3R1/CREB5/CPT1A/SCD/PRKAB1/PRKAB2/CAB39/AKT1S1/IRS4/CPT1C/CPT1B/SCD5/TBC1D1
hsa05212	Pancreatic cancer	52/3197	76/8019	4.02227182228613e-07	3.16876536243517e-06	1.84848948957437e-06	TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/VEGFA/EGFR/E2F1/MTOR/MAPK1/AKT1/SMAD4/TGFBR2/BCL2L1/MAP2K1/BAX/TGFB1/RAD51/STAT3/RB1/GADD45A/CDKN1A/CDKN2A/CDK4/RPS6KB1/CDK6/MAPK10/SMAD3/STAT1/SMAD2/E2F2/E2F3/RAC1/CDC42/TGFA/IKBKG/BRAF/MAPK8/ERBB2/ARHGEF6/MAPK9/PIK3CB/PIK3R2/AKT2/PIK3CA/PIK3R1/CASP9/RALGDS/RALBP1	52	http://www.kegg.jp/kegg-bin/show_pathway?hsa05212/TP53/AKT3/MAPK3/CCND1/TGFB2/BAK1/TGFBR1/KRAS/VEGFA/EGFR/E2F1/MTOR/MAPK1/AKT1/SMAD4/TGFBR2/BCL2L1/MAP2K1/BAX/TGFB1/RAD51/STAT3/RB1/GADD45A/CDKN1A/CDKN2A/CDK4/RPS6KB1/CDK6/MAPK10/SMAD3/STAT1/SMAD2/E2F2/E2F3/RAC1/CDC42/TGFA/IKBKG/BRAF/MAPK8/ERBB2/ARHGEF6/MAPK9/PIK3CB/PIK3R2/AKT2/PIK3CA/PIK3R1/CASP9/RALGDS/RALBP1
hsa04066	HIF-1 signaling pathway	69/3197	109/8019	5.60080114291733e-07	4.30728278371976e-06	2.51264011173484e-06	AKT3/MAPK3/RPS6/VEGFA/EGFR/BCL2/MTOR/MAPK1/AKT1/EDN1/SLC2A1/ALDOA/MAP2K1/ARNT/TIMP1/IGF1/CDKN1B/ANGPT2/STAT3/HIF1A/ENO4/ENO1/TFRC/EP300/CDKN1A/EIF4E/CUL2/CAMK2A/RPS6KB1/EIF4EBP1/RBX1/VHL/CREBBP/ELOB/IGF1R/ERBB2/TLR4/FLT1/PIK3CB/PRKCA/PIK3R2/MAP2K2/HK1/AKT2/PFKP/PRKCB/LDHA/PIK3CA/PDK1/PGK1/CAMK2G/MKNK2/PFKFB3/PFKM/LDHB/GAPDH/HK2/CYBB/PLCG1/PIK3R1/SERPINE1/IL6R/ANGPT4/EGLN3/ELOC/PLCG2/ALDOC/PDHA1/PDHB	69	http://www.kegg.jp/kegg-bin/show_pathway?hsa04066/AKT3/MAPK3/RPS6/VEGFA/EGFR/BCL2/MTOR/MAPK1/AKT1/EDN1/SLC2A1/ALDOA/MAP2K1/ARNT/TIMP1/IGF1/CDKN1B/ANGPT2/STAT3/HIF1A/ENO4/ENO1/TFRC/EP300/CDKN1A/EIF4E/CUL2/CAMK2A/RPS6KB1/EIF4EBP1/RBX1/VHL/CREBBP/ELOB/IGF1R/ERBB2/TLR4/FLT1/PIK3CB/PRKCA/PIK3R2/MAP2K2/HK1/AKT2/PFKP/PRKCB/LDHA/PIK3CA/PDK1/PGK1/CAMK2G/MKNK2/PFKFB3/PFKM/LDHB/GAPDH/HK2/CYBB/PLCG1/PIK3R1/SERPINE1/IL6R/ANGPT4/EGLN3/ELOC/PLCG2/ALDOC/PDHA1/PDHB
hsa04910	Insulin signaling pathway	84/3197	139/8019	6.3763578346434e-07	4.78968274555772e-06	2.79404663990494e-06	AKT3/PPARGC1A/MAPK3/PRKACB/RPS6/KRAS/GRB2/MTOR/MAPK1/SOS1/PRKAR1A/AKT1/SOCS3/CRKL/MAP2K1/PRKAG1/HRAS/EIF4E/RPS6KB1/EIF4EBP1/CALM3/PPP1CB/MAPK10/FOXO1/SREBF1/NRAS/EXOC7/PPP1CC/PPP1R3B/BRAF/MAPK8/MAPK9/IRS2/SHC3/CRK/CALM1/PIK3CB/PIK3R2/MAP2K2/PTPN1/IRS1/PRKAA1/RAPGEF1/PDPK1/PRKAR2A/HK1/AKT2/ACACA/PIK3CA/MKNK2/PHKG1/GCK/PCK1/FASN/GSK3B/HK2/PRKAA2/RHOQ/PHKG2/GYS2/PPP1R3E/PPP1R3D/G6PC/PHKB/PHKA1/FLOT1/TRIP10/SOS2/PIK3R1/CALM2/ELK1/SOCS1/INPPL1/PDE3B/PRKAB1/PRKAB2/FLOT2/CBLB/SOCS4/SHC4/IRS4/PTPRF/INPP5A/CALML4	84	http://www.kegg.jp/kegg-bin/show_pathway?hsa04910/AKT3/PPARGC1A/MAPK3/PRKACB/RPS6/KRAS/GRB2/MTOR/MAPK1/SOS1/PRKAR1A/AKT1/SOCS3/CRKL/MAP2K1/PRKAG1/HRAS/EIF4E/RPS6KB1/EIF4EBP1/CALM3/PPP1CB/MAPK10/FOXO1/SREBF1/NRAS/EXOC7/PPP1CC/PPP1R3B/BRAF/MAPK8/MAPK9/IRS2/SHC3/CRK/CALM1/PIK3CB/PIK3R2/MAP2K2/PTPN1/IRS1/PRKAA1/RAPGEF1/PDPK1/PRKAR2A/HK1/AKT2/ACACA/PIK3CA/MKNK2/PHKG1/GCK/PCK1/FASN/GSK3B/HK2/PRKAA2/RHOQ/PHKG2/GYS2/PPP1R3E/PPP1R3D/G6PC/PHKB/PHKA1/FLOT1/TRIP10/SOS2/PIK3R1/CALM2/ELK1/SOCS1/INPPL1/PDE3B/PRKAB1/PRKAB2/FLOT2/CBLB/SOCS4/SHC4/IRS4/PTPRF/INPP5A/CALML4
hsa05170	Human immunodeficiency virus 1 infection	119/3197	212/8019	9.16517231686526e-07	6.72806967806245e-06	3.92479867157627e-06	AKT3/MAPK14/MAPK3/BAK1/CDC25C/KRAS/BCL2/CASP8/MTOR/MAPK1/AKT1/CRKL/BCL2L1/MAP2K6/MAP2K1/ATM/BAX/CALR/CCNB1/CASP3/FOS/CHEK1/HRAS/WEE1/CUL4A/CUL1/BID/PPP3CA/CUL5/RPS6KB1/FBXW11/CALM3/BTRC/SKP1/RBX1/TNF/MAPK10/TRAF6/NFATC2/JUN/NFATC3/MAP3K7/HLA-A/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/AP1S2/AP1G1/NRAS/AP1B1/AP1S1/AP1S3/GNAI3/DDB1/IKBKG/ELOB/CYCS/PAK3/GNAI2/MAPK8/PAK2/CCR5/IRAK4/PAK4/PAK1/FAS/IRAK1/MAPK9/TLR4/MAP2K7/CXCR4/TAB2/CRK/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/TAB1/MAP2K3/TRIM5/AKT2/PRKCB/PIK3CA/SAMHD1/GNAQ/GNA11/LIMK1/TBK1/NFATC1/PXN/GNB4/GNB2/PLCG1/PIK3R1/CASP9/CALM2/APOBEC3F/TLR2/GNG2/GNG4/ITPR2/ITPR1/ELOC/CD3G/PLCG2/IFNB1/CD3D/TNFRSF1B/PPP3R1/TRADD/GNG12/APOBEC3A/GNB5/GNG5/CFL2/CALML4	119	http://www.kegg.jp/kegg-bin/show_pathway?hsa05170/AKT3/MAPK14/MAPK3/BAK1/CDC25C/KRAS/BCL2/CASP8/MTOR/MAPK1/AKT1/CRKL/BCL2L1/MAP2K6/MAP2K1/ATM/BAX/CALR/CCNB1/CASP3/FOS/CHEK1/HRAS/WEE1/CUL4A/CUL1/BID/PPP3CA/CUL5/RPS6KB1/FBXW11/CALM3/BTRC/SKP1/RBX1/TNF/MAPK10/TRAF6/NFATC2/JUN/NFATC3/MAP3K7/HLA-A/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/AP1S2/AP1G1/NRAS/AP1B1/AP1S1/AP1S3/GNAI3/DDB1/IKBKG/ELOB/CYCS/PAK3/GNAI2/MAPK8/PAK2/CCR5/IRAK4/PAK4/PAK1/FAS/IRAK1/MAPK9/TLR4/MAP2K7/CXCR4/TAB2/CRK/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/TAB1/MAP2K3/TRIM5/AKT2/PRKCB/PIK3CA/SAMHD1/GNAQ/GNA11/LIMK1/TBK1/NFATC1/PXN/GNB4/GNB2/PLCG1/PIK3R1/CASP9/CALM2/APOBEC3F/TLR2/GNG2/GNG4/ITPR2/ITPR1/ELOC/CD3G/PLCG2/IFNB1/CD3D/TNFRSF1B/PPP3R1/TRADD/GNG12/APOBEC3A/GNB5/GNG5/CFL2/CALML4
hsa05218	Melanoma	49/3197	72/8019	1.11456318175901e-06	8.00008683795912e-06	4.66682595403188e-06	TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/PDGFRA/E2F1/MAPK1/AKT1/PTEN/PDGFB/MAP2K1/BAX/IGF1/PDGFRB/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/CDK6/MITF/E2F2/FGFR1/E2F3/NRAS/PDGFA/PDGFD/PDGFC/BRAF/IGF1R/FGF19/FGF2/MET/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/FGF23/HGF/AKT2/PIK3CA/CDH1/PIK3R1	49	http://www.kegg.jp/kegg-bin/show_pathway?hsa05218/TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/PDGFRA/E2F1/MAPK1/AKT1/PTEN/PDGFB/MAP2K1/BAX/IGF1/PDGFRB/RB1/HRAS/MDM2/GADD45A/CDKN1A/CDKN2A/CDK4/CDK6/MITF/E2F2/FGFR1/E2F3/NRAS/PDGFA/PDGFD/PDGFC/BRAF/IGF1R/FGF19/FGF2/MET/FGF5/PIK3CB/PIK3R2/MAP2K2/FGF7/FGF23/HGF/AKT2/PIK3CA/CDH1/PIK3R1
hsa04137	Mitophagy - animal	45/3197	65/8019	1.46105015358346e-06	1.02591130349447e-05	5.98462191055926e-06	TP53/UBB/KRAS/FOXO3/E2F1/BCL2L1/SRC/HIF1A/GABARAPL1/BECN1/GABARAP/ATG9A/ULK1/AMBRA1/MFN2/HRAS/OPTN/CSNK2A1/MAPK10/JUN/MITF/SQSTM1/PRKN/NRAS/MAPK8/MAPK9/RRAS/NBR1/MFN1/MRAS/RRAS2/TBK1/SP1/BNIP3/USP8/CALCOCO2/BNIP3L/TOMM7/ATF4/TFE3/PGAM5/TAX1BP1/BCL2L13/TBC1D15/USP15	45	http://www.kegg.jp/kegg-bin/show_pathway?hsa04137/TP53/UBB/KRAS/FOXO3/E2F1/BCL2L1/SRC/HIF1A/GABARAPL1/BECN1/GABARAP/ATG9A/ULK1/AMBRA1/MFN2/HRAS/OPTN/CSNK2A1/MAPK10/JUN/MITF/SQSTM1/PRKN/NRAS/MAPK8/MAPK9/RRAS/NBR1/MFN1/MRAS/RRAS2/TBK1/SP1/BNIP3/USP8/CALCOCO2/BNIP3L/TOMM7/ATF4/TFE3/PGAM5/TAX1BP1/BCL2L13/TBC1D15/USP15
hsa04350	TGF-beta signaling pathway	60/3197	94/8019	2.03904623447885e-06	1.40130198667376e-05	8.17445186946729e-06	MAPK3/TGFB2/TGFBR1/MAPK1/SMAD4/TGFBR2/ACVR1B/ID4/BMPR2/INHBA/BMP7/PPP2R1A/ACVR1/SMAD5/TGFB1/NODAL/BMPR1A/AMH/EP300/E2F4/TFDP1/CDKN2B/CUL1/MYC/RBL1/ID2/RPS6KB1/SKP1/RBX1/TNF/SMAD3/E2F5/BMP2/SMAD2/SMAD7/ACVR2B/CREBBP/ID1/TGIF1/LEFTY1/ROCK1/PPP2R1B/PPP2CB/THBS1/BMP8A/BMP8B/RHOA/SP1/SMAD6/NEO1/BAMBI/GREM1/NBL1/FBN1/THSD4/GREM2/ZFYVE9/RGMA/RGMB/ZFYVE16	60	http://www.kegg.jp/kegg-bin/show_pathway?hsa04350/MAPK3/TGFB2/TGFBR1/MAPK1/SMAD4/TGFBR2/ACVR1B/ID4/BMPR2/INHBA/BMP7/PPP2R1A/ACVR1/SMAD5/TGFB1/NODAL/BMPR1A/AMH/EP300/E2F4/TFDP1/CDKN2B/CUL1/MYC/RBL1/ID2/RPS6KB1/SKP1/RBX1/TNF/SMAD3/E2F5/BMP2/SMAD2/SMAD7/ACVR2B/CREBBP/ID1/TGIF1/LEFTY1/ROCK1/PPP2R1B/PPP2CB/THBS1/BMP8A/BMP8B/RHOA/SP1/SMAD6/NEO1/BAMBI/GREM1/NBL1/FBN1/THSD4/GREM2/ZFYVE9/RGMA/RGMB/ZFYVE16
hsa04014	Ras signaling pathway	127/3197	232/8019	2.41019396455201e-06	1.62185968864645e-05	9.46106841348266e-06	AKT3/MAPK3/PRKACB/KRAS/VEGFA/EGFR/GRB2/PDGFRA/MAPK1/SOS1/AKT1/ETS1/IGF2/CSF1/KIT/PDGFB/BCL2L1/MAP2K1/IGF1/PDGFRB/STK4/ANGPT2/KITLG/PTPN11/RAB5A/HRAS/FOXO4/CALM3/MAPK10/ETS2/EFNA1/FGFR1/REL/RASGRP1/RAC1/CDC42/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PLCE1/PDGFC/EXOC2/ABL1/IKBKG/BRAP/SHOC2/PAK3/MAPK8/PAK2/IGF1R/KDR/PAK4/PAK1/RASGRP3/FGF19/MAPK9/FLT1/RASAL3/SHC3/RRAS/PLA2G5/RAP1B/FGF2/MET/FGF5/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/FGFR3/FGF7/RASA1/RAP1A/TIAM1/RASAL2/FGF23/FGFR4/RASA4/HGF/AKT2/PRKCB/RHOA/RAB5B/PIK3CA/RAB5C/MRAS/ARF6/ABL2/RRAS2/KSR2/TBK1/EFNA5/GNB4/GNB2/SOS2/PLCG1/PIK3R1/EFNA3/BDNF/GAB2/NGFR/CALM2/ELK1/GNG2/GRIN2A/VEGFB/ANGPT4/GNG4/PLA2G4A/PLCG2/PLA2G2F/PLA2G2D/GNG12/HTR7/SHC4/RALGDS/GNB5/RASSF5/PLA2G2C/RALBP1/GNG5/PLA2G12A/PLA2G4D/CALML4	127	http://www.kegg.jp/kegg-bin/show_pathway?hsa04014/AKT3/MAPK3/PRKACB/KRAS/VEGFA/EGFR/GRB2/PDGFRA/MAPK1/SOS1/AKT1/ETS1/IGF2/CSF1/KIT/PDGFB/BCL2L1/MAP2K1/IGF1/PDGFRB/STK4/ANGPT2/KITLG/PTPN11/RAB5A/HRAS/FOXO4/CALM3/MAPK10/ETS2/EFNA1/FGFR1/REL/RASGRP1/RAC1/CDC42/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PLCE1/PDGFC/EXOC2/ABL1/IKBKG/BRAP/SHOC2/PAK3/MAPK8/PAK2/IGF1R/KDR/PAK4/PAK1/RASGRP3/FGF19/MAPK9/FLT1/RASAL3/SHC3/RRAS/PLA2G5/RAP1B/FGF2/MET/FGF5/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/FGFR3/FGF7/RASA1/RAP1A/TIAM1/RASAL2/FGF23/FGFR4/RASA4/HGF/AKT2/PRKCB/RHOA/RAB5B/PIK3CA/RAB5C/MRAS/ARF6/ABL2/RRAS2/KSR2/TBK1/EFNA5/GNB4/GNB2/SOS2/PLCG1/PIK3R1/EFNA3/BDNF/GAB2/NGFR/CALM2/ELK1/GNG2/GRIN2A/VEGFB/ANGPT4/GNG4/PLA2G4A/PLCG2/PLA2G2F/PLA2G2D/GNG12/HTR7/SHC4/RALGDS/GNB5/RASSF5/PLA2G2C/RALBP1/GNG5/PLA2G12A/PLA2G4D/CALML4
hsa05169	Epstein-Barr virus infection	112/3197	201/8019	3.0865178255991e-06	2.02179875537435e-05	1.17941006098097e-05	TP53/AKT3/MAPK14/CCND1/BAK1/BCL2/CASP8/E2F1/AKT1/CCNE2/CCNE1/ICAM1/NCOR2/MAP2K6/CDK2/BAX/BCL2L11/CALR/CDKN1B/HES1/CASP3/PSMD13/STAT3/HDAC2/RBPJ/CD40/RB1/MDM2/GADD45A/CDKN1A/CCND3/CCNA2/CCND2/CDK4/TNFAIP3/MYC/BID/CDK6/PSMD4/PSMD1/PSMC4/PSMD2/SIN3A/PSMD8/PSMD11/PSMD3/HDAC1/TNF/MAPK10/TRAF6/JUN/STAT1/SNW1/E2F2/RUNX3/E2F3/MAP3K7/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/IKBKG/CYCS/MAP2K4/MAPK8/IRAK4/FAS/IRAK1/MAPK9/MAP2K7/TAB2/EIF2AK2/SYK/PIK3CB/PIK3R2/TAB1/MAP2K3/CD44/LYN/BTK/AKT2/PIK3CA/OAS2/OAS3/ENTPD1/APAF1/TBK1/STAT2/HLA-DOB/IFNAR1/ADRM1/USP7/SEM1/CXCL10/PIK3R1/CASP9/RBPJL/NFKB2/TLR2/VIM/CD3G/PLCG2/IFNB1/CD3D/TRAF3/MAVS/TRADD/IFNAR2	112	http://www.kegg.jp/kegg-bin/show_pathway?hsa05169/TP53/AKT3/MAPK14/CCND1/BAK1/BCL2/CASP8/E2F1/AKT1/CCNE2/CCNE1/ICAM1/NCOR2/MAP2K6/CDK2/BAX/BCL2L11/CALR/CDKN1B/HES1/CASP3/PSMD13/STAT3/HDAC2/RBPJ/CD40/RB1/MDM2/GADD45A/CDKN1A/CCND3/CCNA2/CCND2/CDK4/TNFAIP3/MYC/BID/CDK6/PSMD4/PSMD1/PSMC4/PSMD2/SIN3A/PSMD8/PSMD11/PSMD3/HDAC1/TNF/MAPK10/TRAF6/JUN/STAT1/SNW1/E2F2/RUNX3/E2F3/MAP3K7/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/IKBKG/CYCS/MAP2K4/MAPK8/IRAK4/FAS/IRAK1/MAPK9/MAP2K7/TAB2/EIF2AK2/SYK/PIK3CB/PIK3R2/TAB1/MAP2K3/CD44/LYN/BTK/AKT2/PIK3CA/OAS2/OAS3/ENTPD1/APAF1/TBK1/STAT2/HLA-DOB/IFNAR1/ADRM1/USP7/SEM1/CXCL10/PIK3R1/CASP9/RBPJL/NFKB2/TLR2/VIM/CD3G/PLCG2/IFNB1/CD3D/TRAF3/MAVS/TRADD/IFNAR2
hsa04211	Longevity regulating pathway	57/3197	89/8019	3.12971943556402e-06	2.02179875537435e-05	1.17941006098097e-05	TP53/AKT3/PPARGC1A/SESN2/PPARG/SIRT1/PRKACB/KRAS/FOXO3/MTOR/AKT1/STK11/BAX/IGF1/PRKAG1/ADIPOR2/RB1CC1/ULK1/HRAS/ATF2/EIF4E/RPS6KB1/EIF4EBP1/FOXO1/EHMT2/EHMT1/CREB3/NRAS/IGF1R/CAMKK2/ADIPOQ/IRS2/PIK3CB/PIK3R2/IRS1/PRKAA1/AKT2/ADCY9/PIK3CA/ADCY2/ADCY5/PRKAA2/CAMK4/CREB1/SOD2/SESN3/SESN1/CREB3L2/PIK3R1/ATF6B/ATF4/CREB5/PRKAB1/PRKAB2/APPL1/AKT1S1/IRS4	57	http://www.kegg.jp/kegg-bin/show_pathway?hsa04211/TP53/AKT3/PPARGC1A/SESN2/PPARG/SIRT1/PRKACB/KRAS/FOXO3/MTOR/AKT1/STK11/BAX/IGF1/PRKAG1/ADIPOR2/RB1CC1/ULK1/HRAS/ATF2/EIF4E/RPS6KB1/EIF4EBP1/FOXO1/EHMT2/EHMT1/CREB3/NRAS/IGF1R/CAMKK2/ADIPOQ/IRS2/PIK3CB/PIK3R2/IRS1/PRKAA1/AKT2/ADCY9/PIK3CA/ADCY2/ADCY5/PRKAA2/CAMK4/CREB1/SOD2/SESN3/SESN1/CREB3L2/PIK3R1/ATF6B/ATF4/CREB5/PRKAB1/PRKAB2/APPL1/AKT1S1/IRS4
hsa04115	p53 signaling pathway	48/3197	72/8019	3.56233879813257e-06	2.25614790548396e-05	1.31611691406755e-05	TP53/SESN2/CCND1/BCL2/CASP8/CCNE2/CCNE1/PTEN/BCL2L1/CDK2/ATM/BAX/IGF1/CCNB1/CASP3/CHEK1/STEAP3/MDM2/MDM4/GADD45A/CDKN1A/SFN/CHEK2/CCND3/CCNG1/CDKN2A/CCND2/CDK4/BID/RRM2/CDK6/PPM1D/CYCS/FAS/THBS1/IGFBP3/AIFM2/APAF1/SESN3/SESN1/BBC3/CASP9/SERPINE1/EI24/PMAIP1/TNFRSF10B/GORAB/ZMAT3	48	http://www.kegg.jp/kegg-bin/show_pathway?hsa04115/TP53/SESN2/CCND1/BCL2/CASP8/CCNE2/CCNE1/PTEN/BCL2L1/CDK2/ATM/BAX/IGF1/CCNB1/CASP3/CHEK1/STEAP3/MDM2/MDM4/GADD45A/CDKN1A/SFN/CHEK2/CCND3/CCNG1/CDKN2A/CCND2/CDK4/BID/RRM2/CDK6/PPM1D/CYCS/FAS/THBS1/IGFBP3/AIFM2/APAF1/SESN3/SESN1/BBC3/CASP9/SERPINE1/EI24/PMAIP1/TNFRSF10B/GORAB/ZMAT3
hsa04919	Thyroid hormone signaling pathway	72/3197	119/8019	3.75200737692149e-06	2.33057381297239e-05	1.35953303738653e-05	TP53/AKT3/MAPK3/CCND1/PRKACB/KRAS/CTNNB1/ESR1/MTOR/MAPK1/AKT1/RXRA/SLC2A1/PLCD1/MAP2K1/SRC/THRA/NOTCH1/WNT4/PLCD3/HDAC2/HIF1A/THRB/HRAS/EP300/MDM2/ACTB/MYC/SIN3A/HDAC1/NCOR1/FOXO1/STAT1/NOTCH3/CREBBP/NCOA2/KAT2A/NOTCH2/NRAS/PLCE1/MED12/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/AKT2/PFKP/PRKCB/PIK3CA/ATP1A2/ATP2A2/ACTG1/GSK3B/NCOA3/PLCG1/PIK3R1/ITGB3/CASP9/DIO2/ATP1B3/PLCG2/FXYD2/SLC16A10/MED13/ATP1B4/MED24/MED4/MED13L/DIO1/MED16/MED17	72	http://www.kegg.jp/kegg-bin/show_pathway?hsa04919/TP53/AKT3/MAPK3/CCND1/PRKACB/KRAS/CTNNB1/ESR1/MTOR/MAPK1/AKT1/RXRA/SLC2A1/PLCD1/MAP2K1/SRC/THRA/NOTCH1/WNT4/PLCD3/HDAC2/HIF1A/THRB/HRAS/EP300/MDM2/ACTB/MYC/SIN3A/HDAC1/NCOR1/FOXO1/STAT1/NOTCH3/CREBBP/NCOA2/KAT2A/NOTCH2/NRAS/PLCE1/MED12/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/AKT2/PFKP/PRKCB/PIK3CA/ATP1A2/ATP2A2/ACTG1/GSK3B/NCOA3/PLCG1/PIK3R1/ITGB3/CASP9/DIO2/ATP1B3/PLCG2/FXYD2/SLC16A10/MED13/ATP1B4/MED24/MED4/MED13L/DIO1/MED16/MED17
hsa04360	Axon guidance	102/3197	181/8019	4.3069759722525e-06	2.62481743214634e-05	1.53117914405799e-05	MAPK3/KRAS/PTCH1/SLIT3/MAPK1/WNT5A/BMPR2/SRC/BMP7/ITGB1/TRPC3/ROBO2/WNT4/PTPN11/TRPC4/TRPC1/HRAS/PPP3CA/CAMK2A/NFATC2/EFNA1/NCK2/SEMA4D/NFATC3/RAC1/CDC42/NRAS/ROCK1/GNAI3/ABL1/PAK3/GNAI2/PAK2/ROCK2/PAK4/RYK/PAK1/SEMA7A/SEMA6A/NRP1/RGS3/CXCR4/RRAS/ROBO1/EPHA7/MET/FYN/PIK3CB/PRKCA/PIK3R2/RASA1/EPHA4/EPHB1/ILK/SEMA4C/RHOA/PIK3CA/PDK1/EPHA6/CAMK2G/GSK3B/LIMK1/EFNA5/PARD6B/SRGAP2/PARD3/PLCG1/DCC/DPYSL2/SEMA5A/PIK3R1/NEO1/SEMA6D/EFNA3/PLXNB1/PLXNC1/PLXNA3/SSH2/PLXNA1/SSH1/SEMA3C/CXCL12/ENAH/UNC5D/SEMA4G/SEMA3F/EFNB2/SEMA3E/UNC5B/EFNB1/PLXNB2/UNC5C/PLXNA2/ABLIM3/ABLIM1/PLCG2/MYL12A/PPP3R1/LRRC4/SRGAP1/CFL2/RGMA	102	http://www.kegg.jp/kegg-bin/show_pathway?hsa04360/MAPK3/KRAS/PTCH1/SLIT3/MAPK1/WNT5A/BMPR2/SRC/BMP7/ITGB1/TRPC3/ROBO2/WNT4/PTPN11/TRPC4/TRPC1/HRAS/PPP3CA/CAMK2A/NFATC2/EFNA1/NCK2/SEMA4D/NFATC3/RAC1/CDC42/NRAS/ROCK1/GNAI3/ABL1/PAK3/GNAI2/PAK2/ROCK2/PAK4/RYK/PAK1/SEMA7A/SEMA6A/NRP1/RGS3/CXCR4/RRAS/ROBO1/EPHA7/MET/FYN/PIK3CB/PRKCA/PIK3R2/RASA1/EPHA4/EPHB1/ILK/SEMA4C/RHOA/PIK3CA/PDK1/EPHA6/CAMK2G/GSK3B/LIMK1/EFNA5/PARD6B/SRGAP2/PARD3/PLCG1/DCC/DPYSL2/SEMA5A/PIK3R1/NEO1/SEMA6D/EFNA3/PLXNB1/PLXNC1/PLXNA3/SSH2/PLXNA1/SSH1/SEMA3C/CXCL12/ENAH/UNC5D/SEMA4G/SEMA3F/EFNB2/SEMA3E/UNC5B/EFNB1/PLXNB2/UNC5C/PLXNA2/ABLIM3/ABLIM1/PLCG2/MYL12A/PPP3R1/LRRC4/SRGAP1/CFL2/RGMA
hsa05162	Measles	81/3197	138/8019	5.1324585342768e-06	3.06997056772483e-05	1.79085785114142e-05	TP53/AKT3/CCND1/BAK1/IL1B/BCL2/CASP8/AKT1/CCNE2/CCNE1/BCL2L1/CDK2/BAX/HSPA2/CDKN1B/CASP3/STAT3/FOS/CD28/EIF2AK4/CCND3/CCND2/CDK4/TNFAIP3/BID/CDK6/CSNK2A1/MAPK10/HSPA1A/TRAF6/JUN/STAT1/MAP3K7/TLR7/IKBKG/CYCS/MAPK8/IRAK4/FAS/IRAK1/MAPK9/TLR4/TAB2/IL2RB/EIF2AK2/IL2RA/PIK3CB/PIK3R2/HSPA1B/AKT2/HSPA8/PIK3CA/EIF2AK1/OAS2/OAS3/HSPA6/MX1/GSK3B/APAF1/TBK1/RAB9B/STAT2/RACK1/BBC3/IFNAR1/PIK3R1/CASP9/MSN/STAT5A/TLR2/ADAR/EIF3H/CD3G/IFNB1/CD3D/CBLB/TRAF3/MAVS/TRADD/IFNAR2/EIF2S1	81	http://www.kegg.jp/kegg-bin/show_pathway?hsa05162/TP53/AKT3/CCND1/BAK1/IL1B/BCL2/CASP8/AKT1/CCNE2/CCNE1/BCL2L1/CDK2/BAX/HSPA2/CDKN1B/CASP3/STAT3/FOS/CD28/EIF2AK4/CCND3/CCND2/CDK4/TNFAIP3/BID/CDK6/CSNK2A1/MAPK10/HSPA1A/TRAF6/JUN/STAT1/MAP3K7/TLR7/IKBKG/CYCS/MAPK8/IRAK4/FAS/IRAK1/MAPK9/TLR4/TAB2/IL2RB/EIF2AK2/IL2RA/PIK3CB/PIK3R2/HSPA1B/AKT2/HSPA8/PIK3CA/EIF2AK1/OAS2/OAS3/HSPA6/MX1/GSK3B/APAF1/TBK1/RAB9B/STAT2/RACK1/BBC3/IFNAR1/PIK3R1/CASP9/MSN/STAT5A/TLR2/ADAR/EIF3H/CD3G/IFNB1/CD3D/CBLB/TRAF3/MAVS/TRADD/IFNAR2/EIF2S1
hsa05203	Viral carcinogenesis	111/3197	201/8019	6.01320660390609e-06	3.5313922419303e-05	2.06002675999845e-05	TP53/MAPK3/CCND1/BAK1/PRKACB/KRAS/GRB2/CASP8/UBE3A/MAPK1/CCNE2/CCNE1/HDAC4/SRC/CDK2/DDX3X/BAX/TBP/CDKN1B/CASP3/TBPL1/STAT3/HDAC2/RBPJ/CHEK1/ATP6V0D1/RB1/HRAS/EP300/MDM2/CDKN1A/ATF2/CDKN2B/CCND3/CCNA2/CDKN2A/GTF2H1/CCND2/CDK4/RBL1/CDK6/YWHAE/YWHAG/HDAC11/HDAC1/CHD4/HDAC7/HDAC8/HDAC5/JUN/SNW1/REL/CREBBP/SRF/KAT2A/TBPL2/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/CDC42/CREB3/NRAS/DDB1/IKBKG/YWHAB/CCR5/EIF2AK2/SYK/PIK3CB/PIK3R2/LYN/MAPKAPK2/RHOA/PIK3CA/PKM/CREB1/HNRNPK/PXN/MRPS18B/C3/GTF2H2C/GTF2A1/GTF2H3/GTF2E1/USP7/CREB3L2/PIK3R1/YWHAH/ACTN4/ACTN1/EGR2/RBPJL/ATF6B/ATF4/STAT5A/EGR3/NFKB2/CREB5/GSN/SND1/IL6ST/CCR4/PMAIP1/YWHAZ/UBR4/TRAF3/YWHAQ/TRADD/TRAF1	111	http://www.kegg.jp/kegg-bin/show_pathway?hsa05203/TP53/MAPK3/CCND1/BAK1/PRKACB/KRAS/GRB2/CASP8/UBE3A/MAPK1/CCNE2/CCNE1/HDAC4/SRC/CDK2/DDX3X/BAX/TBP/CDKN1B/CASP3/TBPL1/STAT3/HDAC2/RBPJ/CHEK1/ATP6V0D1/RB1/HRAS/EP300/MDM2/CDKN1A/ATF2/CDKN2B/CCND3/CCNA2/CDKN2A/GTF2H1/CCND2/CDK4/RBL1/CDK6/YWHAE/YWHAG/HDAC11/HDAC1/CHD4/HDAC7/HDAC8/HDAC5/JUN/SNW1/REL/CREBBP/SRF/KAT2A/TBPL2/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/CDC42/CREB3/NRAS/DDB1/IKBKG/YWHAB/CCR5/EIF2AK2/SYK/PIK3CB/PIK3R2/LYN/MAPKAPK2/RHOA/PIK3CA/PKM/CREB1/HNRNPK/PXN/MRPS18B/C3/GTF2H2C/GTF2A1/GTF2H3/GTF2E1/USP7/CREB3L2/PIK3R1/YWHAH/ACTN4/ACTN1/EGR2/RBPJL/ATF6B/ATF4/STAT5A/EGR3/NFKB2/CREB5/GSN/SND1/IL6ST/CCR4/PMAIP1/YWHAZ/UBR4/TRAF3/YWHAQ/TRADD/TRAF1
hsa04934	Cushing syndrome	89/3197	155/8019	6.26954934979113e-06	3.61618649996881e-05	2.10949122859514e-05	MAPK3/CCND1/WNT9B/PRKACB/FZD5/EGFR/LEF1/CTNNB1/E2F1/MAPK1/CCNE2/WNT5A/CCNE1/FZD4/MAP2K1/WNT7A/CDK2/ARNT/MC2R/CDKN1B/KMT2D/WNT4/STAR/WNT7B/RB1/APC/CDKN1A/ATF2/CDKN2B/CDKN2A/CDK4/CAMK2A/CDK6/TCF7L2/E2F2/FZD8/E2F3/WDR5/CREB3/GNAI3/BRAF/GNAI2/WNT16/DVL3/PDE8A/RAP1B/MAP2K2/RAP1A/DVL2/FZD7/GNAS/ADCY9/CAMK2G/ADCY2/PDE11A/GSK3B/GNAQ/ADCY5/GNA11/RASD1/APC2/ASH2L/CREB1/SP1/HSD3B1/USP8/SCARB1/LDLR/AIPL1/CREB3L2/AXIN2/ATF6B/ATF4/AHR/KMT2A/CREB5/WNT8B/FZD9/FZD1/CACNA1C/WNT10A/ITPR2/KCNK2/ITPR1/KCNK3/FZD6/FZD2/CYP11A1/WDR5B	89	http://www.kegg.jp/kegg-bin/show_pathway?hsa04934/MAPK3/CCND1/WNT9B/PRKACB/FZD5/EGFR/LEF1/CTNNB1/E2F1/MAPK1/CCNE2/WNT5A/CCNE1/FZD4/MAP2K1/WNT7A/CDK2/ARNT/MC2R/CDKN1B/KMT2D/WNT4/STAR/WNT7B/RB1/APC/CDKN1A/ATF2/CDKN2B/CDKN2A/CDK4/CAMK2A/CDK6/TCF7L2/E2F2/FZD8/E2F3/WDR5/CREB3/GNAI3/BRAF/GNAI2/WNT16/DVL3/PDE8A/RAP1B/MAP2K2/RAP1A/DVL2/FZD7/GNAS/ADCY9/CAMK2G/ADCY2/PDE11A/GSK3B/GNAQ/ADCY5/GNA11/RASD1/APC2/ASH2L/CREB1/SP1/HSD3B1/USP8/SCARB1/LDLR/AIPL1/CREB3L2/AXIN2/ATF6B/ATF4/AHR/KMT2A/CREB5/WNT8B/FZD9/FZD1/CACNA1C/WNT10A/ITPR2/KCNK2/ITPR1/KCNK3/FZD6/FZD2/CYP11A1/WDR5B
hsa04151	PI3K-Akt signaling pathway	181/3197	354/8019	7.54981168128133e-06	4.27822661939275e-05	2.49569028799512e-05	TP53/AKT3/MAPK3/CCND1/RPS6/KRAS/VEGFA/EGFR/BCL2/FOXO3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/CCNE2/IGF2/CSF1/KIT/CCNE1/RXRA/PTEN/PDGFB/HSP90AB1/ITGA5/BCL2L1/MAP2K1/CDK2/ITGB1/PPP2R1A/STK11/BCL2L11/IGF1/PDGFRB/EREG/ITGB8/CDKN1B/ANGPT2/TNC/KITLG/PRLR/ITGA3/ITGA2/IL7R/HRAS/MDM2/CDKN1A/ATF2/CCND3/CDC37/CCND2/CDK4/MYC/EIF4E/RPS6KB1/EIF4EBP1/CDK6/YWHAE/HSP90AA1/PPP2R2A/YWHAG/EFNA1/FGFR1/RAC1/CREB3/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PDGFC/IKBKG/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/IGF1R/ERBB2/KDR/YWHAB/ERBB3/FGF19/PIK3CG/ITGA1/THBS1/TLR4/PHLPP1/FLT1/IL2RB/ERBB4/FN1/FGF2/MET/FGF5/SYK/IL2RA/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/FGFR3/FGF7/IRS1/FGF23/PRKAA1/FGFR4/HGF/PDPK1/AKT2/PKN3/PIK3CA/HSP90B1/SGK3/C8orf44-SGK3/PCK1/SGK1/GSK3B/PRKAA2/EFNA5/PPP2R3C/CREB1/GYS2/G6PC/COL1A1/GNB4/GNB2/COL6A1/IFNAR1/SOS2/CREB3L2/LAMA2/ITGA7/PIK3R1/YWHAH/EFNA3/TNR/BDNF/LAMC1/COL4A4/ITGA8/ITGB3/CASP9/NGFR/ATF6B/ATF4/CREB5/COL1A2/TLR2/COL4A1/GNG2/COL9A2/ITGA11/IL6R/CHRM2/VEGFB/THBS2/ANGPT4/COL4A2/GNG4/ITGB4/LAMA4/DDIT4/MCL1/THEM4/EIF4B/PHLPP2/IFNB1/YWHAZ/YWHAQ/IFNAR2/GNG12/ITGA9/OSMR/COL4A5/GNB5/GNG5/LPAR2	181	http://www.kegg.jp/kegg-bin/show_pathway?hsa04151/TP53/AKT3/MAPK3/CCND1/RPS6/KRAS/VEGFA/EGFR/BCL2/FOXO3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/CCNE2/IGF2/CSF1/KIT/CCNE1/RXRA/PTEN/PDGFB/HSP90AB1/ITGA5/BCL2L1/MAP2K1/CDK2/ITGB1/PPP2R1A/STK11/BCL2L11/IGF1/PDGFRB/EREG/ITGB8/CDKN1B/ANGPT2/TNC/KITLG/PRLR/ITGA3/ITGA2/IL7R/HRAS/MDM2/CDKN1A/ATF2/CCND3/CDC37/CCND2/CDK4/MYC/EIF4E/RPS6KB1/EIF4EBP1/CDK6/YWHAE/HSP90AA1/PPP2R2A/YWHAG/EFNA1/FGFR1/RAC1/CREB3/NRAS/NTRK2/TGFA/PDGFA/PDGFD/PDGFC/IKBKG/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/IGF1R/ERBB2/KDR/YWHAB/ERBB3/FGF19/PIK3CG/ITGA1/THBS1/TLR4/PHLPP1/FLT1/IL2RB/ERBB4/FN1/FGF2/MET/FGF5/SYK/IL2RA/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/FGFR3/FGF7/IRS1/FGF23/PRKAA1/FGFR4/HGF/PDPK1/AKT2/PKN3/PIK3CA/HSP90B1/SGK3/C8orf44-SGK3/PCK1/SGK1/GSK3B/PRKAA2/EFNA5/PPP2R3C/CREB1/GYS2/G6PC/COL1A1/GNB4/GNB2/COL6A1/IFNAR1/SOS2/CREB3L2/LAMA2/ITGA7/PIK3R1/YWHAH/EFNA3/TNR/BDNF/LAMC1/COL4A4/ITGA8/ITGB3/CASP9/NGFR/ATF6B/ATF4/CREB5/COL1A2/TLR2/COL4A1/GNG2/COL9A2/ITGA11/IL6R/CHRM2/VEGFB/THBS2/ANGPT4/COL4A2/GNG4/ITGB4/LAMA4/DDIT4/MCL1/THEM4/EIF4B/PHLPP2/IFNB1/YWHAZ/YWHAQ/IFNAR2/GNG12/ITGA9/OSMR/COL4A5/GNB5/GNG5/LPAR2
hsa04144	Endocytosis	133/3197	249/8019	7.79988307485838e-06	4.28225192788045e-05	2.49803843927196e-05	UBB/TGFBR1/EGFR/ARRB1/PDGFRA/TGFBR2/DNM2/EPN1/SRC/ARRB2/HSPA2/IGF2R/TFRC/CLTC/RAB11B/SH3GLB1/RAB5A/VPS4A/CHMP2A/CHMP1B/HRAS/MDM2/HSPA1A/SMAD3/TRAF6/SMAD2/HLA-A/HLA-B/HLA-C/HLA-E/CDC42/ARF3/VPS45/ARFGEF2/ARFGAP2/RAB8A/ARF1/FOLR1/CAV2/ASAP2/ARFGEF1/RAB10/CYTH2/RAB31/CYTH3/WASL/WIPF2/IGF1R/CCR5/CXCR4/IL2RB/IL2RA/FGFR3/HGS/RNF41/ITCH/FGFR4/PIP5K1A/HSPA1B/EHD4/KIF5B/RHOA/HSPA8/GRK2/RAB5B/RAB5C/KIF5C/GRK3/KIF5A/ARF6/GRK7/EHD3/AGAP1/EHD2/HSPA6/DNM1/RAB22A/GRK4/PARD6B/CHMP3/PARD3/VPS35/AP2A1/USP8/STAMBP/SNX2/AP2B1/LDLR/AP2M1/DAB2/VPS37A/VPS37D/VPS37B/VPS37C/ZFYVE27/SPART/WASHC2C/CAPZB/ARPC2/RAB11FIP4/EPN2/LDLRAP1/SNX5/IQSEC1/ASAP3/PSD3/PSD4/SNX4/ARPC5/CBLB/ASAP1/ARPC1B/ARPC4/CAPZA2/CAPZA1/RAB11FIP1/EEA1/GIT2/SNX12/RBSN/ARPC5L/ARAP2/CLTB/ZFYVE9/EPS15L1/STAM/VTA1/AGAP9/ACAP2/DNAJC6/ZFYVE16/IQSEC2/RNF103-CHMP3	133	http://www.kegg.jp/kegg-bin/show_pathway?hsa04144/UBB/TGFBR1/EGFR/ARRB1/PDGFRA/TGFBR2/DNM2/EPN1/SRC/ARRB2/HSPA2/IGF2R/TFRC/CLTC/RAB11B/SH3GLB1/RAB5A/VPS4A/CHMP2A/CHMP1B/HRAS/MDM2/HSPA1A/SMAD3/TRAF6/SMAD2/HLA-A/HLA-B/HLA-C/HLA-E/CDC42/ARF3/VPS45/ARFGEF2/ARFGAP2/RAB8A/ARF1/FOLR1/CAV2/ASAP2/ARFGEF1/RAB10/CYTH2/RAB31/CYTH3/WASL/WIPF2/IGF1R/CCR5/CXCR4/IL2RB/IL2RA/FGFR3/HGS/RNF41/ITCH/FGFR4/PIP5K1A/HSPA1B/EHD4/KIF5B/RHOA/HSPA8/GRK2/RAB5B/RAB5C/KIF5C/GRK3/KIF5A/ARF6/GRK7/EHD3/AGAP1/EHD2/HSPA6/DNM1/RAB22A/GRK4/PARD6B/CHMP3/PARD3/VPS35/AP2A1/USP8/STAMBP/SNX2/AP2B1/LDLR/AP2M1/DAB2/VPS37A/VPS37D/VPS37B/VPS37C/ZFYVE27/SPART/WASHC2C/CAPZB/ARPC2/RAB11FIP4/EPN2/LDLRAP1/SNX5/IQSEC1/ASAP3/PSD3/PSD4/SNX4/ARPC5/CBLB/ASAP1/ARPC1B/ARPC4/CAPZA2/CAPZA1/RAB11FIP1/EEA1/GIT2/SNX12/RBSN/ARPC5L/ARAP2/CLTB/ZFYVE9/EPS15L1/STAM/VTA1/AGAP9/ACAP2/DNAJC6/ZFYVE16/IQSEC2/RNF103-CHMP3
hsa04213	Longevity regulating pathway - multiple species	42/3197	62/8019	7.82207008498286e-06	4.28225192788045e-05	2.49803843927196e-05	AKT3/SIRT1/PRKACB/KRAS/FOXO3/MTOR/AKT1/IGF1/HSPA2/SOD1/PRKAG1/HDAC2/HRAS/RPS6KB1/HDAC1/HSPA1A/FOXO1/NRAS/IGF1R/IRS2/PIK3CB/PIK3R2/IRS1/PRKAA1/HSPA1B/CLPB/AKT2/ADCY9/HSPA8/PIK3CA/ADCY2/HSPA6/ADCY5/PRKAA2/SOD2/FOXA2/PIK3R1/PRKAB1/PRKAB2/AKT1S1/EIF4EBP2/IRS4	42	http://www.kegg.jp/kegg-bin/show_pathway?hsa04213/AKT3/SIRT1/PRKACB/KRAS/FOXO3/MTOR/AKT1/IGF1/HSPA2/SOD1/PRKAG1/HDAC2/HRAS/RPS6KB1/HDAC1/HSPA1A/FOXO1/NRAS/IGF1R/IRS2/PIK3CB/PIK3R2/IRS1/PRKAA1/HSPA1B/CLPB/AKT2/ADCY9/HSPA8/PIK3CA/ADCY2/HSPA6/ADCY5/PRKAA2/SOD2/FOXA2/PIK3R1/PRKAB1/PRKAB2/AKT1S1/EIF4EBP2/IRS4
hsa05168	Herpes simplex virus 1 infection	242/3197	491/8019	8.01389349004072e-06	4.31414599547192e-05	2.51664374511805e-05	TP53/AKT3/BAK1/IL1B/BCL2/CASP8/MTOR/AKT1/SOCS3/ITGA5/EIF2B2/BCL2L1/SRC/BAX/CALR/BIRC3/BIRC2/CASP3/PTPN11/EIF2B5/ALYREF/NECTIN1/EIF2AK4/BID/CCL2/EIF4EBP1/PPP1CB/TNF/TRAF6/STAT1/ZNF354B/ZNF157/ZNF254/ZNF268/ZNF746/ZNF8/ZNF136/ZNF350/ZNF675/HCFC1/ZNF431/HCFC2/ZNF224/MAP3K7/HLA-A/HLA-DRB1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/IKBKG/CYCS/PPP1CC/DAXX/IRAK4/CCL5/FAS/IRAK1/TAB2/EIF2AK2/SYK/PIK3CB/JAK2/PIK3R2/TAB1/AKT2/PIK3CA/EIF2AK1/OAS2/OAS3/RNASEL/APAF1/TBK1/SRSF1/STAT2/SRSF2/HLA-DOB/C3/IFNAR1/NXF1/SRSF3/SRSF7/TNFSF14/ZNF540/PIK3R1/ZNF135/ITGB3/CASP9/POU2F1/POU2F2/POU2F3/ZNF317/ZNF419/ZNF616/ZNF546/ZNF561/ZNF100/ZNF398/ZNF544/ZNF208/ZNF454/ZNF43/ZNF584/ZIK1/ZNF620/ZNF285/ZNF250/ZNF107/ZNF33A/ZFP1/ZNF7/ZNF701/ZNF471/ZNF562/ZNF85/ZNF181/ZNF606/ZNF83/ZNF583/ZNF560/ZNF404/ZFP14/ZNF331/ZNF623/ZNF439/ZNF234/ZNF786/ZNF860/ZNF480/ZNF226/ZNF347/ZNF556/ZNF235/ZNF548/ZNF221/ZNF529/ZNF17/ZNF251/ZNF418/ZNF99/ZNF552/ZNF490/ZNF74/ZNF669/ZNF417/ZNF154/ZNF614/ZNF432/ZNF749/ZNF91/ZNF264/ZNF333/ZNF790/ZNF550/ZNF791/ZNF124/ZNF726/ZNF607/ZNF641/ZNF514/ZNF426/ZNF730/ZNF79/ZNF813/ZNF665/ZFP30/ZNF267/ZNF528/ZNF677/ZNF415/ZFP37/ZNF354C/ZNF141/ZNF799/ZNF705A/ZNF611/ZNF320/ZNF257/ZNF587/ZNF662/ZNF566/ZNF101/ZNF468/ZNF570/ZNF619/ZNF554/ZNF275/ZNF582/ZNF324B/ZNF682/ZNF793/ZNF772/ZFP28/ZNF549/ZNF37A/ZNF716/ZNF878/ZNF785/ZNF200/ZNF382/ZNF763/ZNF429/ZNF621/ZNF460/ZFP69B/RBAK/ZNF713/ZNF708/ZNF34/ZNF383/ZNF284/ZNF551/ZNF12/ZNF555/ZNF557/ZNF443/ZNF440/ZNF169/ZNF25/ZNF689/ZNF841/ZNF736/TLR2/TICAM1/IFNB1/TRAF3/MAVS/TRADD/IFNAR2/EIF2B3/ZNF714/EIF2S1/ZNF780A/ZNF688/ZNF850/ZNF486/ZNF571/ZNF783/ZNF470/ZNF585B/ZNF223	242	http://www.kegg.jp/kegg-bin/show_pathway?hsa05168/TP53/AKT3/BAK1/IL1B/BCL2/CASP8/MTOR/AKT1/SOCS3/ITGA5/EIF2B2/BCL2L1/SRC/BAX/CALR/BIRC3/BIRC2/CASP3/PTPN11/EIF2B5/ALYREF/NECTIN1/EIF2AK4/BID/CCL2/EIF4EBP1/PPP1CB/TNF/TRAF6/STAT1/ZNF354B/ZNF157/ZNF254/ZNF268/ZNF746/ZNF8/ZNF136/ZNF350/ZNF675/HCFC1/ZNF431/HCFC2/ZNF224/MAP3K7/HLA-A/HLA-DRB1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/IKBKG/CYCS/PPP1CC/DAXX/IRAK4/CCL5/FAS/IRAK1/TAB2/EIF2AK2/SYK/PIK3CB/JAK2/PIK3R2/TAB1/AKT2/PIK3CA/EIF2AK1/OAS2/OAS3/RNASEL/APAF1/TBK1/SRSF1/STAT2/SRSF2/HLA-DOB/C3/IFNAR1/NXF1/SRSF3/SRSF7/TNFSF14/ZNF540/PIK3R1/ZNF135/ITGB3/CASP9/POU2F1/POU2F2/POU2F3/ZNF317/ZNF419/ZNF616/ZNF546/ZNF561/ZNF100/ZNF398/ZNF544/ZNF208/ZNF454/ZNF43/ZNF584/ZIK1/ZNF620/ZNF285/ZNF250/ZNF107/ZNF33A/ZFP1/ZNF7/ZNF701/ZNF471/ZNF562/ZNF85/ZNF181/ZNF606/ZNF83/ZNF583/ZNF560/ZNF404/ZFP14/ZNF331/ZNF623/ZNF439/ZNF234/ZNF786/ZNF860/ZNF480/ZNF226/ZNF347/ZNF556/ZNF235/ZNF548/ZNF221/ZNF529/ZNF17/ZNF251/ZNF418/ZNF99/ZNF552/ZNF490/ZNF74/ZNF669/ZNF417/ZNF154/ZNF614/ZNF432/ZNF749/ZNF91/ZNF264/ZNF333/ZNF790/ZNF550/ZNF791/ZNF124/ZNF726/ZNF607/ZNF641/ZNF514/ZNF426/ZNF730/ZNF79/ZNF813/ZNF665/ZFP30/ZNF267/ZNF528/ZNF677/ZNF415/ZFP37/ZNF354C/ZNF141/ZNF799/ZNF705A/ZNF611/ZNF320/ZNF257/ZNF587/ZNF662/ZNF566/ZNF101/ZNF468/ZNF570/ZNF619/ZNF554/ZNF275/ZNF582/ZNF324B/ZNF682/ZNF793/ZNF772/ZFP28/ZNF549/ZNF37A/ZNF716/ZNF878/ZNF785/ZNF200/ZNF382/ZNF763/ZNF429/ZNF621/ZNF460/ZFP69B/RBAK/ZNF713/ZNF708/ZNF34/ZNF383/ZNF284/ZNF551/ZNF12/ZNF555/ZNF557/ZNF443/ZNF440/ZNF169/ZNF25/ZNF689/ZNF841/ZNF736/TLR2/TICAM1/IFNB1/TRAF3/MAVS/TRADD/IFNAR2/EIF2B3/ZNF714/EIF2S1/ZNF780A/ZNF688/ZNF850/ZNF486/ZNF571/ZNF783/ZNF470/ZNF585B/ZNF223
hsa04935	Growth hormone synthesis, secretion and action	71/3197	119/8019	8.81128462658866e-06	4.66564743342318e-05	2.72169102357096e-05	AKT3/MAPK14/MAPK3/PRKACB/KRAS/GRB2/MTOR/MAPK1/SOS1/AKT1/SOCS3/SSTR2/CRKL/MAP2K6/MAP2K1/IGF1/JUNB/SSTR3/STAT3/FOS/HRAS/EP300/ATF2/MAPK10/STAT1/CREBBP/CREB3/NRAS/GNAI3/MAP2K4/GNAI2/MAPK8/MAPK9/IRS2/SHC3/CRK/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/MAP2K3/IRS1/IGFBP3/GNAS/AKT2/PRKCB/ADCY9/PIK3CA/ADCY2/GSK3B/GNAQ/ADCY5/GNA11/CREB1/SOS2/CREB3L2/PLCG1/PIK3R1/ATF6B/ATF4/STAT5A/CREB5/SOCS1/CACNA1C/BCAR1/ITPR2/ITPR1/PLCG2/SHC4/IRS4	71	http://www.kegg.jp/kegg-bin/show_pathway?hsa04935/AKT3/MAPK14/MAPK3/PRKACB/KRAS/GRB2/MTOR/MAPK1/SOS1/AKT1/SOCS3/SSTR2/CRKL/MAP2K6/MAP2K1/IGF1/JUNB/SSTR3/STAT3/FOS/HRAS/EP300/ATF2/MAPK10/STAT1/CREBBP/CREB3/NRAS/GNAI3/MAP2K4/GNAI2/MAPK8/MAPK9/IRS2/SHC3/CRK/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/MAP2K3/IRS1/IGFBP3/GNAS/AKT2/PRKCB/ADCY9/PIK3CA/ADCY2/GSK3B/GNAQ/ADCY5/GNA11/CREB1/SOS2/CREB3L2/PLCG1/PIK3R1/ATF6B/ATF4/STAT5A/CREB5/SOCS1/CACNA1C/BCAR1/ITPR2/ITPR1/PLCG2/SHC4/IRS4
hsa04215	Apoptosis - multiple species	25/3197	32/8019	1.15377033900909e-05	6.01077128225703e-05	3.5063648672772e-05	BAK1/BCL2/CASP8/BCL2L1/BAX/BCL2L11/BIRC3/BIRC2/CASP3/BIRC6/BECN1/BID/MAPK10/CYCS/MAPK8/MAPK9/APAF1/XIAP/BIRC5/BBC3/CASP9/NGFR/PMAIP1/DIABLO/CASP7	25	http://www.kegg.jp/kegg-bin/show_pathway?hsa04215/BAK1/BCL2/CASP8/BCL2L1/BAX/BCL2L11/BIRC3/BIRC2/CASP3/BIRC6/BECN1/BID/MAPK10/CYCS/MAPK8/MAPK9/APAF1/XIAP/BIRC5/BBC3/CASP9/NGFR/PMAIP1/DIABLO/CASP7
hsa05163	Human cytomegalovirus infection	121/3197	225/8019	1.30582044309751e-05	6.69492068445234e-05	3.9054613085122e-05	TP53/AKT3/MAPK14/MAPK3/CCND1/BAK1/IL1B/PRKACB/KRAS/VEGFA/EGFR/PTGS2/GRB2/PDGFRA/CTNNB1/CASP8/E2F1/MTOR/MAPK1/SOS1/AKT1/CRKL/MAP2K6/MAP2K1/SRC/BAX/CALR/CASP3/STAT3/RB1/HRAS/MDM2/CDKN1A/ATF2/CDKN2A/CDK4/MYC/BID/CCL2/PPP3CA/RPS6KB1/EIF4EBP1/CDK6/CALM3/TNF/NFATC2/E2F2/NFATC3/E2F3/HLA-A/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/CREB3/NRAS/ROCK1/GNAI3/IKBKG/CYCS/GNAI2/ROCK2/CCR5/CCL5/FAS/CXCR4/CRK/AKAP13/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNA12/GNAS/AKT2/PRKCB/ADCY9/RHOA/PIK3CA/ADCY2/GNA13/GSK3B/GNAQ/ADCY5/GNA11/TBK1/CREB1/NFATC1/SP1/PXN/GNB4/GNB2/SOS2/CREB3L2/PIK3R1/CXCL12/ITGB3/CASP9/CALM2/ATF6B/ELK1/ATF4/CREB5/GNG2/IL6R/CXCL8/BCAR1/GNG4/PTGER3/ITPR2/ITPR1/IFNB1/PPP3R1/TRADD/GNG12/IL10RB/GNB5/GNG5/CALML4	121	http://www.kegg.jp/kegg-bin/show_pathway?hsa05163/TP53/AKT3/MAPK14/MAPK3/CCND1/BAK1/IL1B/PRKACB/KRAS/VEGFA/EGFR/PTGS2/GRB2/PDGFRA/CTNNB1/CASP8/E2F1/MTOR/MAPK1/SOS1/AKT1/CRKL/MAP2K6/MAP2K1/SRC/BAX/CALR/CASP3/STAT3/RB1/HRAS/MDM2/CDKN1A/ATF2/CDKN2A/CDK4/MYC/BID/CCL2/PPP3CA/RPS6KB1/EIF4EBP1/CDK6/CALM3/TNF/NFATC2/E2F2/NFATC3/E2F3/HLA-A/RAC1/HLA-B/HLA-C/TAPBP/HLA-E/CREB3/NRAS/ROCK1/GNAI3/IKBKG/CYCS/GNAI2/ROCK2/CCR5/CCL5/FAS/CXCR4/CRK/AKAP13/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNA12/GNAS/AKT2/PRKCB/ADCY9/RHOA/PIK3CA/ADCY2/GNA13/GSK3B/GNAQ/ADCY5/GNA11/TBK1/CREB1/NFATC1/SP1/PXN/GNB4/GNB2/SOS2/CREB3L2/PIK3R1/CXCL12/ITGB3/CASP9/CALM2/ATF6B/ELK1/ATF4/CREB5/GNG2/IL6R/CXCL8/BCAR1/GNG4/PTGER3/ITPR2/ITPR1/IFNB1/PPP3R1/TRADD/GNG12/IL10RB/GNB5/GNG5/CALML4
hsa04931	Insulin resistance	65/3197	108/8019	1.40763514678092e-05	7.10415863140996e-05	4.14418900121357e-05	AKT3/PPARGC1A/MTOR/AKT1/SOCS3/PTEN/SLC2A1/PRKAG1/PTPN11/STAT3/SLC27A2/SLC27A4/RPS6KB1/PPP1CB/TNF/MAPK10/FOXO1/CD36/PPARA/NR1H3/SREBF1/TRIB3/MLX/NR1H2/OGT/CREB3/PTPA/PPP1CC/PPP1R3B/MAPK8/PRKCD/MAPK9/IRS2/PIK3CB/PIK3R2/PTPN1/IRS1/PRKAA1/PDPK1/SLC27A1/AKT2/RPS6KA2/PRKCB/PIK3CA/RPS6KA3/PCK1/GSK3B/PRKAA2/CREB1/GYS2/PPP1R3E/PPP1R3D/G6PC/PPARGC1B/CREB3L2/PIK3R1/MLXIP/CREB5/CPT1A/PRKAB1/PRKAB2/GFPT2/PTPRF/CPT1B/GFPT1	65	http://www.kegg.jp/kegg-bin/show_pathway?hsa04931/AKT3/PPARGC1A/MTOR/AKT1/SOCS3/PTEN/SLC2A1/PRKAG1/PTPN11/STAT3/SLC27A2/SLC27A4/RPS6KB1/PPP1CB/TNF/MAPK10/FOXO1/CD36/PPARA/NR1H3/SREBF1/TRIB3/MLX/NR1H2/OGT/CREB3/PTPA/PPP1CC/PPP1R3B/MAPK8/PRKCD/MAPK9/IRS2/PIK3CB/PIK3R2/PTPN1/IRS1/PRKAA1/PDPK1/SLC27A1/AKT2/RPS6KA2/PRKCB/PIK3CA/RPS6KA3/PCK1/GSK3B/PRKAA2/CREB1/GYS2/PPP1R3E/PPP1R3D/G6PC/PPARGC1B/CREB3L2/PIK3R1/MLXIP/CREB5/CPT1A/PRKAB1/PRKAB2/GFPT2/PTPRF/CPT1B/GFPT1
hsa05130	Pathogenic Escherichia coli infection	110/3197	202/8019	1.5444851301453e-05	7.67490303133741e-05	4.47713098455074e-05	MAPK14/MAPK3/BAK1/MYH9/IL1B/TNFSF10/CASP8/MAPK1/ITGB1/BAX/CASP3/PTPN11/FOS/RAB1A/ACTB/PTPN6/TUBB/TUBB4B/TUBA1A/TNF/MAPK10/TRAF6/TMBIM6/JUN/NCK2/EZR/MAP3K7/ARHGEF2/MYO1B/RAC1/NLRP3/CDC42/SEC24C/SEC24D/SEC24A/PYCARD/ROCK1/ARF1/TMED10/CYTH2/CYTH3/MYO1D/MYH14/MYH2/MYO10/MYO5A/MYO6/MYO1C/WASL/WIPF2/ABL1/IKBKG/CYCS/PAK3/MAPK8/PAK2/ROCK2/IRAK4/PAK1/FAS/IRAK1/MAPK9/TLR4/TAB2/FYN/TAB1/TIRAP/LYN/IL18/RPS3/GNA12/NAIP/MYH11/RHOA/TUBB2B/MYO1F/ARF6/GAPDH/GNA13/ACTG1/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/CYFIP2/WASF3/BAIAP2/ARPC2/WASF2/CASP9/F2/NCKAP1/CLDN1/CXCL8/NCL/ARPC5/TLR5/TJP1/TNFRSF10B/TNFRSF10A/TRADD/ARPC1B/ARPC4/CLDN16/CLDN7/ARPC5L/CLDN23/LPAR2/CASP7	110	http://www.kegg.jp/kegg-bin/show_pathway?hsa05130/MAPK14/MAPK3/BAK1/MYH9/IL1B/TNFSF10/CASP8/MAPK1/ITGB1/BAX/CASP3/PTPN11/FOS/RAB1A/ACTB/PTPN6/TUBB/TUBB4B/TUBA1A/TNF/MAPK10/TRAF6/TMBIM6/JUN/NCK2/EZR/MAP3K7/ARHGEF2/MYO1B/RAC1/NLRP3/CDC42/SEC24C/SEC24D/SEC24A/PYCARD/ROCK1/ARF1/TMED10/CYTH2/CYTH3/MYO1D/MYH14/MYH2/MYO10/MYO5A/MYO6/MYO1C/WASL/WIPF2/ABL1/IKBKG/CYCS/PAK3/MAPK8/PAK2/ROCK2/IRAK4/PAK1/FAS/IRAK1/MAPK9/TLR4/TAB2/FYN/TAB1/TIRAP/LYN/IL18/RPS3/GNA12/NAIP/MYH11/RHOA/TUBB2B/MYO1F/ARF6/GAPDH/GNA13/ACTG1/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/CYFIP2/WASF3/BAIAP2/ARPC2/WASF2/CASP9/F2/NCKAP1/CLDN1/CXCL8/NCL/ARPC5/TLR5/TJP1/TNFRSF10B/TNFRSF10A/TRADD/ARPC1B/ARPC4/CLDN16/CLDN7/ARPC5L/CLDN23/LPAR2/CASP7
hsa04310	Wnt signaling pathway	90/3197	160/8019	1.72108529198523e-05	8.4228871107762e-05	4.91346518764523e-05	TP53/CCND1/WNT9B/PRKACB/FZD5/LGR4/LEF1/CTNNB1/SMAD4/WNT5A/LRP6/FZD4/WNT7A/PPARD/FOSL1/SENP2/WNT4/WNT7B/SFRP1/PSEN1/APC/EP300/CCND3/CCND2/CUL1/MYC/PPP3CA/CAMK2A/CSNK1E/FBXW11/BTRC/SKP1/RBX1/TBL1X/CSNK2A1/TBL1XR1/TCF7L2/CTBP1/MAPK10/SMAD3/NFATC2/JUN/FZD8/CTNNBIP1/CREBBP/CHD8/NFATC3/MAP3K7/RAC1/NKD1/WNT16/MAPK8/ROCK2/RYK/DVL3/NLK/MAPK9/VANGL2/PRKCA/DVL2/FZD7/PRKCB/RHOA/CSNK1A1/CAMK2G/GSK3B/APC2/NFATC1/LRP5/GPC4/AXIN2/BAMBI/WNT8B/FZD9/SOST/FZD1/PRICKLE1/WNT10A/ZNRF3/PRICKLE4/DAAM1/FZD6/FZD2/VANGL1/PPP3R1/INVS/DKK2/FRAT2/CBY1/PORCN	90	http://www.kegg.jp/kegg-bin/show_pathway?hsa04310/TP53/CCND1/WNT9B/PRKACB/FZD5/LGR4/LEF1/CTNNB1/SMAD4/WNT5A/LRP6/FZD4/WNT7A/PPARD/FOSL1/SENP2/WNT4/WNT7B/SFRP1/PSEN1/APC/EP300/CCND3/CCND2/CUL1/MYC/PPP3CA/CAMK2A/CSNK1E/FBXW11/BTRC/SKP1/RBX1/TBL1X/CSNK2A1/TBL1XR1/TCF7L2/CTBP1/MAPK10/SMAD3/NFATC2/JUN/FZD8/CTNNBIP1/CREBBP/CHD8/NFATC3/MAP3K7/RAC1/NKD1/WNT16/MAPK8/ROCK2/RYK/DVL3/NLK/MAPK9/VANGL2/PRKCA/DVL2/FZD7/PRKCB/RHOA/CSNK1A1/CAMK2G/GSK3B/APC2/NFATC1/LRP5/GPC4/AXIN2/BAMBI/WNT8B/FZD9/SOST/FZD1/PRICKLE1/WNT10A/ZNRF3/PRICKLE4/DAAM1/FZD6/FZD2/VANGL1/PPP3R1/INVS/DKK2/FRAT2/CBY1/PORCN
hsa05010	Alzheimer disease	170/3197	334/8019	1.9975551173938e-05	9.63000452116715e-05	5.61763340162594e-05	AKT3/MAPK3/IL1B/WNT9B/KRAS/FZD5/PTGS2/CTNNB1/CASP8/MTOR/MAPK1/AKT1/WNT5A/VDAC2/CSF1/LRP6/APP/FZD4/MAP2K1/WNT7A/WNT4/CASP3/ADAM10/WNT7B/NDUFAB1/BECN1/PSEN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/APC/HRAS/CDK5R1/ADAM17/BID/PPP3CA/TUBB/CSNK1E/CALM3/TUBB4B/TUBA1A/SDHD/SDHA/SDHC/CSNK2A1/TNF/MAPK10/FZD8/PSENEN/NRAS/APH1A/RTN3/CYCS/BRAF/WNT16/MAPK8/APOE/DVL3/FAS/MAPK9/MAP2K7/IRS2/EIF2AK2/CALM1/PIK3CB/MAP3K5/PIK3R2/MAP2K2/IRS1/DVL2/FZD7/KIF5B/AKT2/IDE/TUBB2B/PIK3CA/CSNK1A1/KIF5C/KIF5A/ATP2A2/GAPDH/NOS1/GSK3B/GNAQ/NDUFS2/CYBB/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/APAF1/MAPT/APC2/LRP5/SLC25A6/PPIF/NDUFA7/CAPN1/NDUFC2/NCSTN/VDAC1/AXIN2/PIK3R1/RTN4/CASP9/CALM2/ATF4/XBP1/LPL/WNT8B/FZD9/FZD1/GRIN2A/CACNA1C/BACE2/WNT10A/CYTB/ITPR2/ITPR1/ND4/NDUFA2/FZD6/FZD2/PPP3R1/GRM5/NDUFS7/COX7A2L/KLC2/MCU/CHRM3/UQCRH/NDUFA4/COX6A1/COX1/IRS4/NDUFA5/CYC1/NDUFS1/UQCRB/EIF2S1/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/DKK2/FRAT2/COX5A/CASP7/NDUFV3/UQCR11/NDUFB6/APH1B/CALML4/NRBF2	170	http://www.kegg.jp/kegg-bin/show_pathway?hsa05010/AKT3/MAPK3/IL1B/WNT9B/KRAS/FZD5/PTGS2/CTNNB1/CASP8/MTOR/MAPK1/AKT1/WNT5A/VDAC2/CSF1/LRP6/APP/FZD4/MAP2K1/WNT7A/WNT4/CASP3/ADAM10/WNT7B/NDUFAB1/BECN1/PSEN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/APC/HRAS/CDK5R1/ADAM17/BID/PPP3CA/TUBB/CSNK1E/CALM3/TUBB4B/TUBA1A/SDHD/SDHA/SDHC/CSNK2A1/TNF/MAPK10/FZD8/PSENEN/NRAS/APH1A/RTN3/CYCS/BRAF/WNT16/MAPK8/APOE/DVL3/FAS/MAPK9/MAP2K7/IRS2/EIF2AK2/CALM1/PIK3CB/MAP3K5/PIK3R2/MAP2K2/IRS1/DVL2/FZD7/KIF5B/AKT2/IDE/TUBB2B/PIK3CA/CSNK1A1/KIF5C/KIF5A/ATP2A2/GAPDH/NOS1/GSK3B/GNAQ/NDUFS2/CYBB/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/APAF1/MAPT/APC2/LRP5/SLC25A6/PPIF/NDUFA7/CAPN1/NDUFC2/NCSTN/VDAC1/AXIN2/PIK3R1/RTN4/CASP9/CALM2/ATF4/XBP1/LPL/WNT8B/FZD9/FZD1/GRIN2A/CACNA1C/BACE2/WNT10A/CYTB/ITPR2/ITPR1/ND4/NDUFA2/FZD6/FZD2/PPP3R1/GRM5/NDUFS7/COX7A2L/KLC2/MCU/CHRM3/UQCRH/NDUFA4/COX6A1/COX1/IRS4/NDUFA5/CYC1/NDUFS1/UQCRB/EIF2S1/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/DKK2/FRAT2/COX5A/CASP7/NDUFV3/UQCR11/NDUFB6/APH1B/CALML4/NRBF2
hsa04015	Rap1 signaling pathway	113/3197	210/8019	2.4199763596584e-05	0.000114948877083774	6.70550725044664e-05	AKT3/MAPK14/MAPK3/KRAS/VEGFA/EGFR/PDGFRA/CTNNB1/MAPK1/AKT1/CSF1/KIT/PDGFB/CRKL/MAP2K6/MAP2K1/SRC/ITGB1/IGF1/PDGFRB/ANGPT2/KITLG/P2RY1/HRAS/ACTB/CALM3/EFNA1/FGFR1/ID1/RAC1/CDC42/NRAS/PDGFA/PDGFD/PLCE1/PDGFC/GNAI3/BRAF/RAPGEF2/GNAI2/IGF1R/KDR/RASGRP3/FGF19/THBS1/FLT1/FPR1/RRAS/RAP1B/CRK/FGF2/MET/MAGI3/FGF5/CALM1/PIK3CB/PRKD2/PRKCA/PIK3R2/MAP2K2/FGFR3/MAP2K3/FGF7/RAP1A/TIAM1/FGF23/ADORA2B/FGFR4/HGF/RAPGEF1/GNAS/AKT2/PRKCB/ADCY9/RHOA/PIK3CA/MRAS/ADCY2/ACTG1/GNAQ/ADCY5/PFN1/EFNA5/PARD6B/PARD3/PLCG1/CDH1/PIK3R1/EFNA3/ENAH/SIPA1L3/ITGB3/VASP/NGFR/EVL/CALM2/GRIN2A/PFN2/VEGFB/ANGPT4/VAV2/VAV3/BCAR1/F2RL3/TLN1/FYB1/DOCK4/RALGDS/RASSF5/LPAR2/PFN4/CTNND1/CALML4	113	http://www.kegg.jp/kegg-bin/show_pathway?hsa04015/AKT3/MAPK14/MAPK3/KRAS/VEGFA/EGFR/PDGFRA/CTNNB1/MAPK1/AKT1/CSF1/KIT/PDGFB/CRKL/MAP2K6/MAP2K1/SRC/ITGB1/IGF1/PDGFRB/ANGPT2/KITLG/P2RY1/HRAS/ACTB/CALM3/EFNA1/FGFR1/ID1/RAC1/CDC42/NRAS/PDGFA/PDGFD/PLCE1/PDGFC/GNAI3/BRAF/RAPGEF2/GNAI2/IGF1R/KDR/RASGRP3/FGF19/THBS1/FLT1/FPR1/RRAS/RAP1B/CRK/FGF2/MET/MAGI3/FGF5/CALM1/PIK3CB/PRKD2/PRKCA/PIK3R2/MAP2K2/FGFR3/MAP2K3/FGF7/RAP1A/TIAM1/FGF23/ADORA2B/FGFR4/HGF/RAPGEF1/GNAS/AKT2/PRKCB/ADCY9/RHOA/PIK3CA/MRAS/ADCY2/ACTG1/GNAQ/ADCY5/PFN1/EFNA5/PARD6B/PARD3/PLCG1/CDH1/PIK3R1/EFNA3/ENAH/SIPA1L3/ITGB3/VASP/NGFR/EVL/CALM2/GRIN2A/PFN2/VEGFB/ANGPT4/VAV2/VAV3/BCAR1/F2RL3/TLN1/FYB1/DOCK4/RALGDS/RASSF5/LPAR2/PFN4/CTNND1/CALML4
hsa05160	Hepatitis C	87/3197	155/8019	2.64371628305957e-05	0.00012375657383018	7.21930152048303e-05	TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/GRB2/CTNNB1/CASP8/E2F1/MAPK1/SOS1/AKT1/SOCS3/RXRA/MAP2K1/CDK2/PPP2R1A/BAX/CASP3/STAT3/EIF2AK4/RB1/HRAS/CDKN1A/CDK4/PSME3/MYC/BID/CDK6/YWHAE/PPP2R2A/YWHAG/TNF/TRAF6/STAT1/PPARA/NR1H3/E2F2/E2F3/NRAS/IKBKG/PPP2R2D/PPP2R1B/CYCS/PPP2CB/BRAF/YWHAB/FAS/EIF2AK2/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/EIF2AK1/OAS2/OAS3/RNASEL/MX1/GSK3B/APAF1/TBK1/STAT2/SCARB1/LDLR/IFNAR1/CXCL10/SOS2/PIK3R1/YWHAH/CASP9/CLDN1/TICAM1/IFNB1/YWHAZ/TRAF3/MAVS/YWHAQ/TRADD/IFNAR2/IFIT1/CLDN16/CLDN7/EIF2S1/CLDN23	87	http://www.kegg.jp/kegg-bin/show_pathway?hsa05160/TP53/AKT3/MAPK3/CCND1/BAK1/KRAS/EGFR/GRB2/CTNNB1/CASP8/E2F1/MAPK1/SOS1/AKT1/SOCS3/RXRA/MAP2K1/CDK2/PPP2R1A/BAX/CASP3/STAT3/EIF2AK4/RB1/HRAS/CDKN1A/CDK4/PSME3/MYC/BID/CDK6/YWHAE/PPP2R2A/YWHAG/TNF/TRAF6/STAT1/PPARA/NR1H3/E2F2/E2F3/NRAS/IKBKG/PPP2R2D/PPP2R1B/CYCS/PPP2CB/BRAF/YWHAB/FAS/EIF2AK2/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/EIF2AK1/OAS2/OAS3/RNASEL/MX1/GSK3B/APAF1/TBK1/STAT2/SCARB1/LDLR/IFNAR1/CXCL10/SOS2/PIK3R1/YWHAH/CASP9/CLDN1/TICAM1/IFNB1/YWHAZ/TRAF3/MAVS/YWHAQ/TRADD/IFNAR2/IFIT1/CLDN16/CLDN7/EIF2S1/CLDN23
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	84/3197	149/8019	2.91128755622763e-05	0.000134335125808789	7.83639808368039e-05	AKT3/IL1B/CASP8/AKT1/SOCS3/RXRA/LEP/BAX/BCL2L11/PRKAG1/CASP3/TGFB1/ADIPOR2/NDUFAB1/BID/SDHD/SDHA/SDHC/TNF/MAPK10/JUN/PPARA/NR1H3/SREBF1/MLX/RAC1/CDC42/CYCS/MAPK8/ADIPOQ/MAP3K11/FAS/MAPK9/IRS2/PIK3CB/MAP3K5/PIK3R2/IRS1/ITCH/PRKAA1/AKT2/PIK3CA/GSK3B/NDUFS2/PRKAA2/NDUFA7/NDUFC2/PIK3R1/ATF4/XBP1/MLXIP/IL6R/CXCL8/PRKAB1/PRKAB2/CYTB/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/EIF2S1/UQCRFS1/COX6C/NDUFB5/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/UQCRC1/COX5A/CASP7/NDUFV3/UQCR11/NDUFB6	84	http://www.kegg.jp/kegg-bin/show_pathway?hsa04932/AKT3/IL1B/CASP8/AKT1/SOCS3/RXRA/LEP/BAX/BCL2L11/PRKAG1/CASP3/TGFB1/ADIPOR2/NDUFAB1/BID/SDHD/SDHA/SDHC/TNF/MAPK10/JUN/PPARA/NR1H3/SREBF1/MLX/RAC1/CDC42/CYCS/MAPK8/ADIPOQ/MAP3K11/FAS/MAPK9/IRS2/PIK3CB/MAP3K5/PIK3R2/IRS1/ITCH/PRKAA1/AKT2/PIK3CA/GSK3B/NDUFS2/PRKAA2/NDUFA7/NDUFC2/PIK3R1/ATF4/XBP1/MLXIP/IL6R/CXCL8/PRKAB1/PRKAB2/CYTB/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/EIF2S1/UQCRFS1/COX6C/NDUFB5/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/UQCRC1/COX5A/CASP7/NDUFV3/UQCR11/NDUFB6
hsa05418	Fluid shear stress and atherosclerosis	79/3197	139/8019	3.38800733938191e-05	0.000154130474735262	8.99115365084302e-05	TP53/AKT3/MEF2A/MAPK14/IL1B/DUSP1/VEGFA/BCL2/MMP2/CTNNB1/AKT1/ICAM1/SDC1/PDGFB/HSP90AB1/EDN1/BMPR2/MAP2K6/SRC/ACVR1/NPPC/MMP9/FOS/BMPR1A/ASS1/ACTB/CCL2/CALM3/HSP90AA1/TNF/MAPK10/MAP2K5/JUN/PIAS4/KLF2/SQSTM1/ACVR2B/MEF2C/SUMO1/TXN/MAP3K7/ARHGEF2/RAC1/PDGFA/CAV2/IKBKG/MAP2K4/MAPK8/KDR/MAPK7/MAPK9/MAP2K7/CALM1/PIK3CB/MAP3K5/PIK3R2/GSTP1/PRKAA1/AKT2/RHOA/PIK3CA/HSP90B1/ACTG1/PRKAA2/NFE2L2/SDC4/PIK3R1/ITGB3/CALM2/SUMO2/VCAM1/PLAT/GSTM4/GSTM3/SELE/GSTO1/MGST3/GSTO2/CALML4	79	http://www.kegg.jp/kegg-bin/show_pathway?hsa05418/TP53/AKT3/MEF2A/MAPK14/IL1B/DUSP1/VEGFA/BCL2/MMP2/CTNNB1/AKT1/ICAM1/SDC1/PDGFB/HSP90AB1/EDN1/BMPR2/MAP2K6/SRC/ACVR1/NPPC/MMP9/FOS/BMPR1A/ASS1/ACTB/CCL2/CALM3/HSP90AA1/TNF/MAPK10/MAP2K5/JUN/PIAS4/KLF2/SQSTM1/ACVR2B/MEF2C/SUMO1/TXN/MAP3K7/ARHGEF2/RAC1/PDGFA/CAV2/IKBKG/MAP2K4/MAPK8/KDR/MAPK7/MAPK9/MAP2K7/CALM1/PIK3CB/MAP3K5/PIK3R2/GSTP1/PRKAA1/AKT2/RHOA/PIK3CA/HSP90B1/ACTG1/PRKAA2/NFE2L2/SDC4/PIK3R1/ITGB3/CALM2/SUMO2/VCAM1/PLAT/GSTM4/GSTM3/SELE/GSTO1/MGST3/GSTO2/CALML4
hsa04917	Prolactin signaling pathway	44/3197	70/8019	8.01684391792479e-05	0.0003568016848205	0.000208139161097831	AKT3/MAPK14/MAPK3/CCND1/KRAS/FOXO3/GRB2/ESR1/MAPK1/SOS1/AKT1/SOCS3/MAP2K1/SRC/PRLR/STAT3/FOS/HRAS/CCND2/MAPK10/STAT1/ESR2/NRAS/MAPK8/MAPK9/SHC3/PIK3CB/JAK2/PIK3R2/MAP2K2/AKT2/PIK3CA/GCK/GSK3B/IRF1/SOS2/PIK3R1/STAT5A/SOCS1/SOCS6/SOCS5/SOCS4/SHC4/SOCS7	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa04917/AKT3/MAPK14/MAPK3/CCND1/KRAS/FOXO3/GRB2/ESR1/MAPK1/SOS1/AKT1/SOCS3/MAP2K1/SRC/PRLR/STAT3/FOS/HRAS/CCND2/MAPK10/STAT1/ESR2/NRAS/MAPK8/MAPK9/SHC3/PIK3CB/JAK2/PIK3R2/MAP2K2/AKT2/PIK3CA/GCK/GSK3B/IRF1/SOS2/PIK3R1/STAT5A/SOCS1/SOCS6/SOCS5/SOCS4/SHC4/SOCS7
hsa04926	Relaxin signaling pathway	73/3197	129/8019	8.0639390067791e-05	0.0003568016848205	0.000208139161097831	AKT3/MAPK14/MAPK3/PRKACB/TGFBR1/KRAS/VEGFA/EGFR/ARRB1/GRB2/MMP2/MAPK1/SOS1/AKT1/TGFBR2/EDN1/MAP2K1/SRC/ARRB2/RLN2/MMP9/TGFB1/FOS/HRAS/ATF2/MAPK10/JUN/SMAD2/CREB3/NRAS/GNAI3/MAP2K4/GNAI2/MAPK8/MAPK9/MAP2K7/SHC3/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNAS/AKT2/ADCY9/PIK3CA/ADCY2/NOS1/ADCY5/CREB1/COL1A1/GNB4/GNB2/SOS2/CREB3L2/PIK3R1/COL4A4/ATF6B/ATF4/CREB5/COL1A2/COL3A1/COL4A1/GNG2/MMP13/VEGFB/COL4A2/GNG4/GNG12/MMP1/SHC4/COL4A5/GNB5/GNG5	73	http://www.kegg.jp/kegg-bin/show_pathway?hsa04926/AKT3/MAPK14/MAPK3/PRKACB/TGFBR1/KRAS/VEGFA/EGFR/ARRB1/GRB2/MMP2/MAPK1/SOS1/AKT1/TGFBR2/EDN1/MAP2K1/SRC/ARRB2/RLN2/MMP9/TGFB1/FOS/HRAS/ATF2/MAPK10/JUN/SMAD2/CREB3/NRAS/GNAI3/MAP2K4/GNAI2/MAPK8/MAPK9/MAP2K7/SHC3/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNAS/AKT2/ADCY9/PIK3CA/ADCY2/NOS1/ADCY5/CREB1/COL1A1/GNB4/GNB2/SOS2/CREB3L2/PIK3R1/COL4A4/ATF6B/ATF4/CREB5/COL1A2/COL3A1/COL4A1/GNG2/MMP13/VEGFB/COL4A2/GNG4/GNG12/MMP1/SHC4/COL4A5/GNB5/GNG5
hsa05222	Small cell lung cancer	55/3197	92/8019	8.22538519997296e-05	0.000359026948593414	0.000209437261848529	TP53/AKT3/CCND1/BAK1/CKS2/PTGS2/BCL2/E2F1/AKT1/CCNE2/CCNE1/RXRA/PTEN/BCL2L1/CDK2/ITGB1/BAX/CDKN1B/BIRC3/ITGA3/ITGA2/BIRC2/CASP3/RB1/GADD45A/CDKN1A/CDKN2B/CDK4/MYC/CDK6/TRAF6/E2F2/E2F3/IKBKG/CYCS/FN1/PIK3CB/PIK3R2/TRAF4/AKT2/PIK3CA/FHIT/APAF1/XIAP/LAMA2/PIK3R1/LAMC1/COL4A4/CASP9/COL4A1/COL4A2/LAMA4/TRAF3/TRAF1/COL4A5	55	http://www.kegg.jp/kegg-bin/show_pathway?hsa05222/TP53/AKT3/CCND1/BAK1/CKS2/PTGS2/BCL2/E2F1/AKT1/CCNE2/CCNE1/RXRA/PTEN/BCL2L1/CDK2/ITGB1/BAX/CDKN1B/BIRC3/ITGA3/ITGA2/BIRC2/CASP3/RB1/GADD45A/CDKN1A/CDKN2B/CDK4/MYC/CDK6/TRAF6/E2F2/E2F3/IKBKG/CYCS/FN1/PIK3CB/PIK3R2/TRAF4/AKT2/PIK3CA/FHIT/APAF1/XIAP/LAMA2/PIK3R1/LAMC1/COL4A4/CASP9/COL4A1/COL4A2/LAMA4/TRAF3/TRAF1/COL4A5
hsa04330	Notch signaling pathway	35/3197	53/8019	0.00010040608540038	0.000432415541124303	0.000252248270690077	HEY1/NCOR2/NOTCH1/HES1/HEY2/JAG2/HDAC2/RBPJ/PSEN1/EP300/ADAM17/HDAC1/CTBP1/ATXN1/NOTCH3/SNW1/CREBBP/HEYL/ATXN1L/DLL4/KAT2A/PSENEN/NOTCH2/APH1A/DVL3/DVL2/DTX3L/NCSTN/NUMB/RBPJL/JAG1/DTX4/MAML1/MAML3/APH1B	35	http://www.kegg.jp/kegg-bin/show_pathway?hsa04330/HEY1/NCOR2/NOTCH1/HES1/HEY2/JAG2/HDAC2/RBPJ/PSEN1/EP300/ADAM17/HDAC1/CTBP1/ATXN1/NOTCH3/SNW1/CREBBP/HEYL/ATXN1L/DLL4/KAT2A/PSENEN/NOTCH2/APH1A/DVL3/DVL2/DTX3L/NCSTN/NUMB/RBPJL/JAG1/DTX4/MAML1/MAML3/APH1B
hsa05134	Legionellosis	37/3197	57/8019	0.000110498941613181	0.00046962050185602	0.000273951669650408	IL1B/CASP8/HSPA2/CASP3/RAB1A/RAB1B/EEF1A1/TNF/HSPA1A/SAR1B/PYCARD/ARF1/SAR1A/CYCS/TLR4/IL18/HSPA1B/NAIP/HSPA8/HBS1L/HSPD1/HSPA6/VCP/CLK4/APAF1/BNIP3/C3/CASP9/NFKB2/TLR2/CXCL8/CR1/CXCL1/CXCL3/TLR5/BCL2L13/CASP7	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa05134/IL1B/CASP8/HSPA2/CASP3/RAB1A/RAB1B/EEF1A1/TNF/HSPA1A/SAR1B/PYCARD/ARF1/SAR1A/CYCS/TLR4/IL18/HSPA1B/NAIP/HSPA8/HBS1L/HSPD1/HSPA6/VCP/CLK4/APAF1/BNIP3/C3/CASP9/NFKB2/TLR2/CXCL8/CR1/CXCL1/CXCL3/TLR5/BCL2L13/CASP7
hsa04920	Adipocytokine signaling pathway	43/3197	69/8019	0.000128639234534077	0.00053961652927931	0.000314783636112095	AKT3/PPARGC1A/ACSL4/MTOR/AKT1/SOCS3/RXRA/SLC2A1/LEP/STK11/PRKAG1/PTPN11/ADIPOR2/STAT3/ACSBG1/TNF/MAPK10/CD36/PPARA/IKBKG/MAPK8/CAMKK2/ADIPOQ/MAPK9/IRS2/JAK2/IRS1/PRKAA1/ACSL6/AKT2/ACSL3/ACSL1/PCK1/PRKAA2/G6PC/CPT1A/PRKAB1/PRKAB2/TNFRSF1B/TRADD/IRS4/CPT1C/CPT1B	43	http://www.kegg.jp/kegg-bin/show_pathway?hsa04920/AKT3/PPARGC1A/ACSL4/MTOR/AKT1/SOCS3/RXRA/SLC2A1/LEP/STK11/PRKAG1/PTPN11/ADIPOR2/STAT3/ACSBG1/TNF/MAPK10/CD36/PPARA/IKBKG/MAPK8/CAMKK2/ADIPOQ/MAPK9/IRS2/JAK2/IRS1/PRKAA1/ACSL6/AKT2/ACSL3/ACSL1/PCK1/PRKAA2/G6PC/CPT1A/PRKAB1/PRKAB2/TNFRSF1B/TRADD/IRS4/CPT1C/CPT1B
hsa04371	Apelin signaling pathway	76/3197	137/8019	0.000140863204461045	0.000583318141550224	0.000340276836687274	AKT3/PPARGC1A/MEF2A/MAPK3/CCND1/PRKACB/RPS6/TGFBR1/KRAS/MTOR/MAPK1/AKT1/SMAD4/EGR1/HDAC4/MAP2K1/PRKAG1/GABARAPL1/BECN1/PIK3C3/GABARAP/HRAS/RPS6KB1/CALM3/HDAC5/SMAD3/NOTCH3/SMAD2/KLF2/MEF2C/NRAS/GNAI3/GNAI2/PIK3CG/RRAS/CALM1/MAP2K2/PRKAA1/AKT2/ADCY9/MRAS/ADCY2/GNA13/MYLK3/NOS1/RRAS2/GNAQ/ADCY5/PRKAA2/CAMK4/MYLK4/MEF2D/SLC8A1/GNB4/GNB2/CDH1/CALM2/TFAM/NRF1/GNG2/SERPINE1/JAG1/PDE3B/APLN/GNG4/PRKAB1/PRKAB2/ITPR2/ITPR1/PLAT/SLC8A3/GNG12/GNB5/GNG5/PLIN1/CALML4	76	http://www.kegg.jp/kegg-bin/show_pathway?hsa04371/AKT3/PPARGC1A/MEF2A/MAPK3/CCND1/PRKACB/RPS6/TGFBR1/KRAS/MTOR/MAPK1/AKT1/SMAD4/EGR1/HDAC4/MAP2K1/PRKAG1/GABARAPL1/BECN1/PIK3C3/GABARAP/HRAS/RPS6KB1/CALM3/HDAC5/SMAD3/NOTCH3/SMAD2/KLF2/MEF2C/NRAS/GNAI3/GNAI2/PIK3CG/RRAS/CALM1/MAP2K2/PRKAA1/AKT2/ADCY9/MRAS/ADCY2/GNA13/MYLK3/NOS1/RRAS2/GNAQ/ADCY5/PRKAA2/CAMK4/MYLK4/MEF2D/SLC8A1/GNB4/GNB2/CDH1/CALM2/TFAM/NRF1/GNG2/SERPINE1/JAG1/PDE3B/APLN/GNG4/PRKAB1/PRKAB2/ITPR2/ITPR1/PLAT/SLC8A3/GNG12/GNB5/GNG5/PLIN1/CALML4
hsa04922	Glucagon signaling pathway	61/3197	106/8019	0.000160682589940868	0.000656858250936971	0.00038317623241883	AKT3/PPARGC1A/SIRT1/PRKACB/AKT1/SLC2A1/PRKAG1/PPP4C/EP300/ATF2/PPP3CA/CAMK2A/CALM3/FOXO1/PPARA/CREBBP/CREB3/CALM1/PRKAA1/GNAS/AKT2/SIK2/PFKP/ACACA/LDHA/CAMK2G/SIK1/PFKM/ADCY2/LDHB/PHKG1/GCK/PCK1/PKM/GNAQ/PRKAA2/PHKG2/CREB1/GYS2/G6PC/PHKB/PHKA1/CREB3L2/CALM2/ATF4/CREB5/CPT1A/PDE3B/PRKAB1/PRKAB2/ITPR2/ITPR1/PGAM1/PPP3R1/PDHA1/CPT1C/PDHB/CPT1B/PGAM4/CALML4/PPP4R3A	61	http://www.kegg.jp/kegg-bin/show_pathway?hsa04922/AKT3/PPARGC1A/SIRT1/PRKACB/AKT1/SLC2A1/PRKAG1/PPP4C/EP300/ATF2/PPP3CA/CAMK2A/CALM3/FOXO1/PPARA/CREBBP/CREB3/CALM1/PRKAA1/GNAS/AKT2/SIK2/PFKP/ACACA/LDHA/CAMK2G/SIK1/PFKM/ADCY2/LDHB/PHKG1/GCK/PCK1/PKM/GNAQ/PRKAA2/PHKG2/CREB1/GYS2/G6PC/PHKB/PHKA1/CREB3L2/CALM2/ATF4/CREB5/CPT1A/PDE3B/PRKAB1/PRKAB2/ITPR2/ITPR1/PGAM1/PPP3R1/PDHA1/CPT1C/PDHB/CPT1B/PGAM4/CALML4/PPP4R3A
hsa04625	C-type lectin receptor signaling pathway	60/3197	104/8019	0.000164722966953234	0.000656858250936971	0.00038317623241883	AKT3/MAPK14/MAPK3/IL1B/KRAS/PTGS2/CASP8/MAPK1/AKT1/SRC/PTPN11/HRAS/MDM2/PPP3CA/CALM3/TNF/MAPK10/NFATC2/JUN/STAT1/NFATC3/NLRP3/NRAS/PYCARD/IKBKG/MAPK8/PAK1/PRKCD/MAPK9/CYLD/RRAS/CCL22/SYK/CALM1/PIK3CB/PIK3R2/MAPKAPK2/AKT2/RHOA/PIK3CA/MRAS/RRAS2/NFATC1/IRF1/STAT2/BCL10/PIK3R1/EGR2/CALM2/EGR3/NFKB2/BCL3/MALT1/ITPR2/ITPR1/PLCG2/CLEC4E/CBLB/PPP3R1/CALML4	60	http://www.kegg.jp/kegg-bin/show_pathway?hsa04625/AKT3/MAPK14/MAPK3/IL1B/KRAS/PTGS2/CASP8/MAPK1/AKT1/SRC/PTPN11/HRAS/MDM2/PPP3CA/CALM3/TNF/MAPK10/NFATC2/JUN/STAT1/NFATC3/NLRP3/NRAS/PYCARD/IKBKG/MAPK8/PAK1/PRKCD/MAPK9/CYLD/RRAS/CCL22/SYK/CALM1/PIK3CB/PIK3R2/MAPKAPK2/AKT2/RHOA/PIK3CA/MRAS/RRAS2/NFATC1/IRF1/STAT2/BCL10/PIK3R1/EGR2/CALM2/EGR3/NFKB2/BCL3/MALT1/ITPR2/ITPR1/PLCG2/CLEC4E/CBLB/PPP3R1/CALML4
hsa04660	T cell receptor signaling pathway	60/3197	104/8019	0.000164722966953234	0.000656858250936971	0.00038317623241883	AKT3/MAPK14/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K1/FOS/PTPRC/CD28/HRAS/CDK4/PTPN6/PPP3CA/TNF/MAPK10/NFATC2/JUN/NCK2/NFATC3/MAP3K7/RASGRP1/CDC42/NRAS/IKBKG/PAK3/MAPK8/PAK2/CD40LG/PAK4/PAK1/MAP3K8/MAPK9/MAP2K7/FYN/PIK3CB/PIK3R2/MAP2K2/PDPK1/AKT2/RHOA/PIK3CA/GSK3B/TEC/NFATC1/BCL10/SOS2/PLCG1/PIK3R1/VAV2/VAV3/MALT1/CD3G/PDCD1/CD3D/GRAP2/CBLB/PPP3R1	60	http://www.kegg.jp/kegg-bin/show_pathway?hsa04660/AKT3/MAPK14/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K1/FOS/PTPRC/CD28/HRAS/CDK4/PTPN6/PPP3CA/TNF/MAPK10/NFATC2/JUN/NCK2/NFATC3/MAP3K7/RASGRP1/CDC42/NRAS/IKBKG/PAK3/MAPK8/PAK2/CD40LG/PAK4/PAK1/MAP3K8/MAPK9/MAP2K7/FYN/PIK3CB/PIK3R2/MAP2K2/PDPK1/AKT2/RHOA/PIK3CA/GSK3B/TEC/NFATC1/BCL10/SOS2/PLCG1/PIK3R1/VAV2/VAV3/MALT1/CD3G/PDCD1/CD3D/GRAP2/CBLB/PPP3R1
hsa04210	Apoptosis	75/3197	136/8019	0.000199885811844596	0.000787355088119567	0.000459301159437519	TP53/AKT3/PARP1/MAPK3/BAK1/TNFSF10/KRAS/BCL2/CTSB/CASP8/MAPK1/AKT1/BCL2L1/MAP2K1/ATM/CTSV/BAX/BCL2L11/BIRC3/BIRC2/CASP3/FOS/HRAS/GADD45A/ACTB/BID/TUBA1A/TNF/MAPK10/JUN/NRAS/CTSZ/CTSC/IKBKG/CYCS/DAXX/MAPK8/FAS/MAPK9/PIK3CB/MAP3K5/PIK3R2/MAP2K2/PDPK1/AKT2/PIK3CA/ACTG1/TUBA1B/TUBA1C/TUBAL3/APAF1/XIAP/BIRC5/LMNA/DFFA/CAPN1/BBC3/PIK3R1/CASP9/ATF4/PARP2/ITPR2/ITPR1/PMAIP1/MCL1/HRK/TNFRSF10B/TNFRSF10A/TRADD/TRAF1/EIF2S1/DIABLO/CASP7/LMNB2/LMNB1	75	http://www.kegg.jp/kegg-bin/show_pathway?hsa04210/TP53/AKT3/PARP1/MAPK3/BAK1/TNFSF10/KRAS/BCL2/CTSB/CASP8/MAPK1/AKT1/BCL2L1/MAP2K1/ATM/CTSV/BAX/BCL2L11/BIRC3/BIRC2/CASP3/FOS/HRAS/GADD45A/ACTB/BID/TUBA1A/TNF/MAPK10/JUN/NRAS/CTSZ/CTSC/IKBKG/CYCS/DAXX/MAPK8/FAS/MAPK9/PIK3CB/MAP3K5/PIK3R2/MAP2K2/PDPK1/AKT2/PIK3CA/ACTG1/TUBA1B/TUBA1C/TUBAL3/APAF1/XIAP/BIRC5/LMNA/DFFA/CAPN1/BBC3/PIK3R1/CASP9/ATF4/PARP2/ITPR2/ITPR1/PMAIP1/MCL1/HRK/TNFRSF10B/TNFRSF10A/TRADD/TRAF1/EIF2S1/DIABLO/CASP7/LMNB2/LMNB1
hsa05100	Bacterial invasion of epithelial cells	44/3197	73/8019	0.000320548457930883	0.00124743556520091	0.000727687685093571	CTNNA1/CTNNB1/DNM2/ITGA5/CRKL/SRC/ITGB1/MAD2L2/CLTC/ACTB/RAC1/CDC42/CAV2/WASL/SHC3/FN1/CRK/MET/PIK3CB/PIK3R2/ILK/RHOA/PIK3CA/RHOG/ACTG1/DNM1/PXN/VCL/CDH1/PIK3R1/DOCK1/ARHGEF26/ARPC2/WASF2/CTNNA3/BCAR1/CD2AP/ARPC5/ARPC1B/ARPC4/SHC4/ARPC5L/CLTB/ARHGAP10	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa05100/CTNNA1/CTNNB1/DNM2/ITGA5/CRKL/SRC/ITGB1/MAD2L2/CLTC/ACTB/RAC1/CDC42/CAV2/WASL/SHC3/FN1/CRK/MET/PIK3CB/PIK3R2/ILK/RHOA/PIK3CA/RHOG/ACTG1/DNM1/PXN/VCL/CDH1/PIK3R1/DOCK1/ARHGEF26/ARPC2/WASF2/CTNNA3/BCAR1/CD2AP/ARPC5/ARPC1B/ARPC4/SHC4/ARPC5L/CLTB/ARHGAP10
hsa05017	Spinocerebellar ataxia	56/3197	98/8019	0.000377129664744484	0.00144764503607826	0.000844479261717481	OPA1/AKT3/TWNK/MTOR/AKT1/TRPC3/TBP/TBPL1/PUM1/RBPJ/BECN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/MAPK10/ATXN1/CIC/ATXN1L/TBPL2/CACNA1A/MAPK8/MAPK9/PIK3CB/MAP3K5/PRKCA/PIK3R2/SPTBN2/AKT2/PRKCB/PIK3CA/ATP2A2/GNAQ/ATXN3/SP1/VLDLR/PIK3R1/RBPJL/RORA/XBP1/NFYA/ATXN3L/GRIN2A/KCND3/OMA1/ITPR2/ITPR1/PUM2/ATXN2/FGF14/NRBF2	56	http://www.kegg.jp/kegg-bin/show_pathway?hsa05017/OPA1/AKT3/TWNK/MTOR/AKT1/TRPC3/TBP/TBPL1/PUM1/RBPJ/BECN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/MAPK10/ATXN1/CIC/ATXN1L/TBPL2/CACNA1A/MAPK8/MAPK9/PIK3CB/MAP3K5/PRKCA/PIK3R2/SPTBN2/AKT2/PRKCB/PIK3CA/ATP2A2/GNAQ/ATXN3/SP1/VLDLR/PIK3R1/RBPJL/RORA/XBP1/NFYA/ATXN3L/GRIN2A/KCND3/OMA1/ITPR2/ITPR1/PUM2/ATXN2/FGF14/NRBF2
hsa04071	Sphingolipid signaling pathway	66/3197	119/8019	0.000380959220020596	0.00144764503607826	0.000844479261717481	TP53/AKT3/MAPK14/MAPK3/KRAS/BCL2/MAPK1/AKT1/PTEN/MAP2K1/PPP2R1A/BAX/SGPL1/HRAS/BID/PPP2R2A/TNF/MAPK10/CERS1/RAC1/NRAS/ROCK1/SGMS2/ACER2/GNAI3/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/GNAI2/MAPK8/ROCK2/MAPK9/FYN/PIK3CB/MAP3K5/PRKCA/PIK3R2/MAP2K2/S1PR2/PDPK1/GNA12/AKT2/PRKCB/RHOA/PIK3CA/GNA13/ABCC1/GNAQ/PPP2R3C/PIK3R1/GAB2/S1PR1/ADORA3/BDKRB2/OPRD1/DEGS1/TRADD/SPTLC2/SPTLC3/SPTLC1/CERS2/SGPP2/CERS4	66	http://www.kegg.jp/kegg-bin/show_pathway?hsa04071/TP53/AKT3/MAPK14/MAPK3/KRAS/BCL2/MAPK1/AKT1/PTEN/MAP2K1/PPP2R1A/BAX/SGPL1/HRAS/BID/PPP2R2A/TNF/MAPK10/CERS1/RAC1/NRAS/ROCK1/SGMS2/ACER2/GNAI3/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/GNAI2/MAPK8/ROCK2/MAPK9/FYN/PIK3CB/MAP3K5/PRKCA/PIK3R2/MAP2K2/S1PR2/PDPK1/GNA12/AKT2/PRKCB/RHOA/PIK3CA/GNA13/ABCC1/GNAQ/PPP2R3C/PIK3R1/GAB2/S1PR1/ADORA3/BDKRB2/OPRD1/DEGS1/TRADD/SPTLC2/SPTLC3/SPTLC1/CERS2/SGPP2/CERS4
hsa04540	Gap junction	51/3197	88/8019	0.000428783166125445	0.00161042979835487	0.000939439250140204	MAPK3/PRKACB/KRAS/EGFR/GRB2/PDGFRA/MAPK1/SOS1/PDGFB/MAP2K1/SRC/PDGFRB/GJA1/HRAS/TUBB/CSNK1D/TUBB4B/TUBA1A/MAP2K5/NRAS/PDGFA/PDGFD/PDGFC/GNAI3/GNAI2/MAPK7/MAP3K2/PRKCA/MAP2K2/GNAS/PRKCB/ADCY9/TUBB2B/PRKG2/ADCY2/PRKG1/GNAQ/ADCY5/GNA11/TUBB1/TUBB2A/TUBA1B/TUBA1C/GUCY1A2/TUBAL3/SOS2/GJD2/ITPR2/ITPR1/TJP1/GRM5	51	http://www.kegg.jp/kegg-bin/show_pathway?hsa04540/MAPK3/PRKACB/KRAS/EGFR/GRB2/PDGFRA/MAPK1/SOS1/PDGFB/MAP2K1/SRC/PDGFRB/GJA1/HRAS/TUBB/CSNK1D/TUBB4B/TUBA1A/MAP2K5/NRAS/PDGFA/PDGFD/PDGFC/GNAI3/GNAI2/MAPK7/MAP3K2/PRKCA/MAP2K2/GNAS/PRKCB/ADCY9/TUBB2B/PRKG2/ADCY2/PRKG1/GNAQ/ADCY5/GNA11/TUBB1/TUBB2A/TUBA1B/TUBA1C/GUCY1A2/TUBAL3/SOS2/GJD2/ITPR2/ITPR1/TJP1/GRM5
hsa04340	Hedgehog signaling pathway	32/3197	50/8019	0.00046669841430662	0.0017326849174832	0.00101075639638094	CCND1/PRKACB/ARRB1/BCL2/PTCH1/GLI2/ARRB2/GLI1/GLI3/CUL3/CCND2/CUL1/CSNK1E/FBXW11/CSNK1D/BTRC/SUFU/SPOP/CDON/GRK2/CSNK1A1/KIF3A/GRK3/CSNK1G1/CSNK1G3/GSK3B/MGRN1/GAS1/MEGF8/EVC/HHIP/GPR161	32	http://www.kegg.jp/kegg-bin/show_pathway?hsa04340/CCND1/PRKACB/ARRB1/BCL2/PTCH1/GLI2/ARRB2/GLI1/GLI3/CUL3/CCND2/CUL1/CSNK1E/FBXW11/CSNK1D/BTRC/SUFU/SPOP/CDON/GRK2/CSNK1A1/KIF3A/GRK3/CSNK1G1/CSNK1G3/GSK3B/MGRN1/GAS1/MEGF8/EVC/HHIP/GPR161
hsa04664	Fc epsilon RI signaling pathway	41/3197	68/8019	0.000503042934852616	0.00184639622678858	0.00107708953754328	AKT3/MAPK14/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K6/MAP2K1/HRAS/TNF/MAPK10/RAC1/NRAS/MAP2K4/MAPK8/MAPK9/MAP2K7/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/MAP2K3/LYN/PDPK1/BTK/AKT2/PIK3CA/SOS2/PLCG1/PIK3R1/GAB2/VAV2/VAV3/PLA2G4A/PLCG2/ALOX5AP/PLA2G4D	41	http://www.kegg.jp/kegg-bin/show_pathway?hsa04664/AKT3/MAPK14/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K6/MAP2K1/HRAS/TNF/MAPK10/RAC1/NRAS/MAP2K4/MAPK8/MAPK9/MAP2K7/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/MAP2K3/LYN/PDPK1/BTK/AKT2/PIK3CA/SOS2/PLCG1/PIK3R1/GAB2/VAV2/VAV3/PLA2G4A/PLCG2/ALOX5AP/PLA2G4D
hsa04912	GnRH signaling pathway	53/3197	93/8019	0.000585360031312841	0.00211874700145884	0.00123596452097485	MAPK14/MAPK3/PRKACB/KRAS/EGFR/GRB2/MMP2/MAPK1/SOS1/EGR1/MAP3K4/MAP2K6/MAP2K1/SRC/MMP14/HRAS/CAMK2A/CALM3/MAPK10/JUN/CDC42/NRAS/MAP2K4/MAPK8/PRKCD/MAP3K3/MAPK7/MAPK9/MAP2K7/MAP3K2/CALM1/PRKCA/MAP2K2/MAP2K3/HBEGF/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/GNAQ/ADCY5/GNA11/SOS2/CALM2/ELK1/ATF4/CACNA1C/ITPR2/ITPR1/PLA2G4A/PLA2G4D/CALML4	53	http://www.kegg.jp/kegg-bin/show_pathway?hsa04912/MAPK14/MAPK3/PRKACB/KRAS/EGFR/GRB2/MMP2/MAPK1/SOS1/EGR1/MAP3K4/MAP2K6/MAP2K1/SRC/MMP14/HRAS/CAMK2A/CALM3/MAPK10/JUN/CDC42/NRAS/MAP2K4/MAPK8/PRKCD/MAP3K3/MAPK7/MAPK9/MAP2K7/MAP3K2/CALM1/PRKCA/MAP2K2/MAP2K3/HBEGF/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/GNAQ/ADCY5/GNA11/SOS2/CALM2/ELK1/ATF4/CACNA1C/ITPR2/ITPR1/PLA2G4A/PLA2G4D/CALML4
hsa05216	Thyroid cancer	25/3197	37/8019	0.000590362941582959	0.00211874700145884	0.00123596452097485	TP53/PPARG/MAPK3/CCND1/BAK1/KRAS/LEF1/CTNNB1/MAPK1/RXRA/MAP2K1/BAX/NCOA4/TPR/HRAS/GADD45A/CDKN1A/MYC/TCF7L2/NRAS/BRAF/MAP2K2/CDH1/TPM3/CCDC6	25	http://www.kegg.jp/kegg-bin/show_pathway?hsa05216/TP53/PPARG/MAPK3/CCND1/BAK1/KRAS/LEF1/CTNNB1/MAPK1/RXRA/MAP2K1/BAX/NCOA4/TPR/HRAS/GADD45A/CDKN1A/MYC/TCF7L2/NRAS/BRAF/MAP2K2/CDH1/TPM3/CCDC6
hsa03015	mRNA surveillance pathway	52/3197	91/8019	0.000602317154241663	0.00213789495406656	0.00124713442000298	WDR33/PPP2R1A/DAZAP1/ALYREF/DDX39B/GSPT1/PPP2R2A/PPP1CB/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/PABPN1/SMG1/HBS1L/PAPOLG/PAPOLA/EIF4A3/CASC3/RNPS1/RBM8A/PABPC1/MAGOH/ETF1/PPP2R3C/WDR82/CPSF6/NXF1/CPSF2/CSTF2/CPSF7/NUDT21/PCF11/PNN/CSTF2T/CPSF4/CSTF1/PELO/ACIN1/PABPC4/PABPC1L2B/PABPC1L2A/PABPC4L/PABPC3/SSU72/MSI2/MSI1/NXT2/BCL2L2-PABPN1	52	http://www.kegg.jp/kegg-bin/show_pathway?hsa03015/WDR33/PPP2R1A/DAZAP1/ALYREF/DDX39B/GSPT1/PPP2R2A/PPP1CB/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/PABPN1/SMG1/HBS1L/PAPOLG/PAPOLA/EIF4A3/CASC3/RNPS1/RBM8A/PABPC1/MAGOH/ETF1/PPP2R3C/WDR82/CPSF6/NXF1/CPSF2/CSTF2/CPSF7/NUDT21/PCF11/PNN/CSTF2T/CPSF4/CSTF1/PELO/ACIN1/PABPC4/PABPC1L2B/PABPC1L2A/PABPC4L/PABPC3/SSU72/MSI2/MSI1/NXT2/BCL2L2-PABPN1
hsa04120	Ubiquitin mediated proteolysis	73/3197	136/8019	0.000702655875209582	0.00246693312709451	0.00143907782222557	UBE2B/FZR1/UBE3A/SOCS3/HERC4/UBE2A/BIRC3/BIRC2/UBE2Q1/BIRC6/UBE2J1/CDC27/CDC23/ANAPC11/CUL3/ANAPC1/MDM2/CUL4A/CUL1/CUL2/CDC34/CUL5/FBXW11/BTRC/SKP1/RBX1/ERCC8/TRAF6/UBE2D1/UBE2I/PIAS4/UBE2D3/VHL/WWP2/PRKN/TRIM37/UBE2D4/FBXW7/UBE2D2/UBE4A/DDB1/FBXW8/KLHL9/ELOB/SYVN1/UBE2C/UBE4B/FBXO2/UBE2N/MID1/ITCH/UBE2K/UBA1/UBE2H/UBE2F/UBE2G2/UBA6/UBE2Z/UBE2E3/UBA2/UBA7/XIAP/UBE3C/MGRN1/UBOX5/TRIP12/AIRE/PIAS2/SOCS1/ELOC/CBLB/HERC1/SAE1	73	http://www.kegg.jp/kegg-bin/show_pathway?hsa04120/UBE2B/FZR1/UBE3A/SOCS3/HERC4/UBE2A/BIRC3/BIRC2/UBE2Q1/BIRC6/UBE2J1/CDC27/CDC23/ANAPC11/CUL3/ANAPC1/MDM2/CUL4A/CUL1/CUL2/CDC34/CUL5/FBXW11/BTRC/SKP1/RBX1/ERCC8/TRAF6/UBE2D1/UBE2I/PIAS4/UBE2D3/VHL/WWP2/PRKN/TRIM37/UBE2D4/FBXW7/UBE2D2/UBE4A/DDB1/FBXW8/KLHL9/ELOB/SYVN1/UBE2C/UBE4B/FBXO2/UBE2N/MID1/ITCH/UBE2K/UBA1/UBE2H/UBE2F/UBE2G2/UBA6/UBE2Z/UBE2E3/UBA2/UBA7/XIAP/UBE3C/MGRN1/UBOX5/TRIP12/AIRE/PIAS2/SOCS1/ELOC/CBLB/HERC1/SAE1
hsa05231	Choline metabolism in cancer	55/3197	98/8019	0.000774673065453719	0.00269053118431776	0.00156951305847443	AKT3/MAPK3/KRAS/EGFR/PLPP3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/PDGFB/MAP2K1/PDGFRB/FOS/HIF1A/HRAS/RPS6KB1/EIF4EBP1/MAPK10/JUN/RAC1/NRAS/PDGFA/PDGFD/CHPT1/PDGFC/MAPK8/MAPK9/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/PIP5K1A/AKT2/DGKG/PRKCB/DGKE/PIK3CA/DGKD/DGKH/SP1/SOS2/PLCG1/PIK3R1/WASF3/WASF2/SLC22A3/SLC44A1/PLA2G4A/LYPLA1/PCYT1A/RALGDS/PLA2G4D	55	http://www.kegg.jp/kegg-bin/show_pathway?hsa05231/AKT3/MAPK3/KRAS/EGFR/PLPP3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/PDGFB/MAP2K1/PDGFRB/FOS/HIF1A/HRAS/RPS6KB1/EIF4EBP1/MAPK10/JUN/RAC1/NRAS/PDGFA/PDGFD/CHPT1/PDGFC/MAPK8/MAPK9/PIK3CB/PRKCA/PIK3R2/MAP2K2/PDPK1/PIP5K1A/AKT2/DGKG/PRKCB/DGKE/PIK3CA/DGKD/DGKH/SP1/SOS2/PLCG1/PIK3R1/WASF3/WASF2/SLC22A3/SLC44A1/PLA2G4A/LYPLA1/PCYT1A/RALGDS/PLA2G4D
hsa05202	Transcriptional misregulation in cancer	95/3197	186/8019	0.00113162781228956	0.00388846578052688	0.00226832450615711	TP53/PPARG/BAK1/RARA/WT1/SIX4/TGFBR2/RXRA/ETV6/BCL2L1/PAX5/ATM/HOXA9/BAX/IGF1/CDKN1B/BIRC3/MMP9/HOXA10/NUPR1/BCL6/ETV5/HDAC2/CEBPB/FUS/CD40/NSD2/MDM2/HMGA2/GADD45A/CDKN1A/DOT1L/CCNT2/CCNT1/CCNA2/CCND2/MYC/ID2/CDK14/SIN3A/HDAC1/NCOR1/FOXO1/RUNX1/TCF3/MAF/KLF3/MITF/LDB1/SIX1/ELK4/MEF2C/ETV7/REL/PER2/ZEB1/BMI1/FUT8/PDGFA/DUSP6/WNT16/IGF1R/FLT1/IL2RB/MET/IGFBP3/RUNX2/CDK9/BMP2K/SS18/SP1/JMJD1C/MYCN/BCL11B/NGFR/ERG/PBX3/TFE3/FLI1/MEIS1/KMT2A/PAX3/MLLT1/JUP/CXCL8/PROM1/PLAT/TRAF1/AFF1/SSX2B/RUNX1T1/TAF15/SSX2/EWSR1/COMMD3-BMI1	95	http://www.kegg.jp/kegg-bin/show_pathway?hsa05202/TP53/PPARG/BAK1/RARA/WT1/SIX4/TGFBR2/RXRA/ETV6/BCL2L1/PAX5/ATM/HOXA9/BAX/IGF1/CDKN1B/BIRC3/MMP9/HOXA10/NUPR1/BCL6/ETV5/HDAC2/CEBPB/FUS/CD40/NSD2/MDM2/HMGA2/GADD45A/CDKN1A/DOT1L/CCNT2/CCNT1/CCNA2/CCND2/MYC/ID2/CDK14/SIN3A/HDAC1/NCOR1/FOXO1/RUNX1/TCF3/MAF/KLF3/MITF/LDB1/SIX1/ELK4/MEF2C/ETV7/REL/PER2/ZEB1/BMI1/FUT8/PDGFA/DUSP6/WNT16/IGF1R/FLT1/IL2RB/MET/IGFBP3/RUNX2/CDK9/BMP2K/SS18/SP1/JMJD1C/MYCN/BCL11B/NGFR/ERG/PBX3/TFE3/FLI1/MEIS1/KMT2A/PAX3/MLLT1/JUP/CXCL8/PROM1/PLAT/TRAF1/AFF1/SSX2B/RUNX1T1/TAF15/SSX2/EWSR1/COMMD3-BMI1
hsa04915	Estrogen signaling pathway	73/3197	138/8019	0.0012073526437759	0.00410499898883806	0.00239463848460816	AKT3/MAPK3/PRKACB/RARA/KRAS/EGFR/BCL2/GRB2/MMP2/ESR1/MAPK1/SOS1/AKT1/HSP90AB1/MAP2K1/SRC/HSPA2/MMP9/FKBP4/FOS/HRAS/ATF2/CALM3/HSP90AA1/HSPA1A/JUN/ESR2/NCOA2/CREB3/NRAS/TGFA/GPER1/EBAG9/GNAI3/GNAI2/PRKCD/SHC3/CALM1/PIK3CB/PIK3R2/MAP2K2/HBEGF/GNAS/HSPA1B/AKT2/ADCY9/HSPA8/PIK3CA/HSP90B1/ADCY2/HSPA6/GNAQ/ADCY5/CREB1/NCOA3/SP1/FKBP5/SOS2/CREB3L2/PIK3R1/CALM2/ATF6B/ATF4/CREB5/KCNJ3/KCNJ5/ITPR2/ITPR1/SHC4/KCNJ6/GABBR2/KRT33B/CALML4	73	http://www.kegg.jp/kegg-bin/show_pathway?hsa04915/AKT3/MAPK3/PRKACB/RARA/KRAS/EGFR/BCL2/GRB2/MMP2/ESR1/MAPK1/SOS1/AKT1/HSP90AB1/MAP2K1/SRC/HSPA2/MMP9/FKBP4/FOS/HRAS/ATF2/CALM3/HSP90AA1/HSPA1A/JUN/ESR2/NCOA2/CREB3/NRAS/TGFA/GPER1/EBAG9/GNAI3/GNAI2/PRKCD/SHC3/CALM1/PIK3CB/PIK3R2/MAP2K2/HBEGF/GNAS/HSPA1B/AKT2/ADCY9/HSPA8/PIK3CA/HSP90B1/ADCY2/HSPA6/GNAQ/ADCY5/CREB1/NCOA3/SP1/FKBP5/SOS2/CREB3L2/PIK3R1/CALM2/ATF6B/ATF4/CREB5/KCNJ3/KCNJ5/ITPR2/ITPR1/SHC4/KCNJ6/GABBR2/KRT33B/CALML4
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	50/3197	89/8019	0.00127993328508068	0.00430644219876104	0.00251214975909475	AKT3/MAPK14/MAPK3/KRAS/EGFR/MTOR/MAPK1/AKT1/PTEN/MAP2K6/MAP2K1/PTPN11/STAT3/FOS/HIF1A/CD28/HRAS/PTPN6/PPP3CA/RPS6KB1/CSNK2A1/TRAF6/NFATC2/JUN/STAT1/NFATC3/RASGRP1/NRAS/IKBKG/MAP3K3/TLR4/PIK3CB/JAK2/PIK3R2/MAP2K2/TIRAP/MAP2K3/AKT2/PIK3CA/NFATC1/PLCG1/PIK3R1/BATF2/TLR2/TICAM1/CD3G/CD274/PDCD1/CD3D/PPP3R1	50	http://www.kegg.jp/kegg-bin/show_pathway?hsa05235/AKT3/MAPK14/MAPK3/KRAS/EGFR/MTOR/MAPK1/AKT1/PTEN/MAP2K6/MAP2K1/PTPN11/STAT3/FOS/HIF1A/CD28/HRAS/PTPN6/PPP3CA/RPS6KB1/CSNK2A1/TRAF6/NFATC2/JUN/STAT1/NFATC3/RASGRP1/NRAS/IKBKG/MAP3K3/TLR4/PIK3CB/JAK2/PIK3R2/MAP2K2/TIRAP/MAP2K3/AKT2/PIK3CA/NFATC1/PLCG1/PIK3R1/BATF2/TLR2/TICAM1/CD3G/CD274/PDCD1/CD3D/PPP3R1
hsa04928	Parathyroid hormone synthesis, secretion and action	58/3197	106/8019	0.00130890756916213	0.00435852726638525	0.00254253342246361	MEF2A/MAPK3/PRKACB/EGFR/ARRB1/VDR/BCL2/MAPK1/LRP6/RXRA/EGR1/MAP2K1/ARRB2/GCM1/CYP27B1/FOS/MMP14/CDKN1A/ATF2/NR4A2/MEF2C/FGFR1/CREB3/GNAI3/BRAF/GNAI2/AKAP13/PRKCA/HBEGF/FGF23/GNA12/GNAS/PRKCB/ADCY9/RHOA/ADCY2/RUNX2/GNA13/GNAQ/ADCY5/GNA11/PDE4A/MEF2D/CREB1/SP1/LRP5/CREB3L2/MAFB/ATF6B/ATF4/CREB5/MMP16/MMP13/SOST/ITPR2/ITPR1/NACA/PDE4C	58	http://www.kegg.jp/kegg-bin/show_pathway?hsa04928/MEF2A/MAPK3/PRKACB/EGFR/ARRB1/VDR/BCL2/MAPK1/LRP6/RXRA/EGR1/MAP2K1/ARRB2/GCM1/CYP27B1/FOS/MMP14/CDKN1A/ATF2/NR4A2/MEF2C/FGFR1/CREB3/GNAI3/BRAF/GNAI2/AKAP13/PRKCA/HBEGF/FGF23/GNA12/GNAS/PRKCB/ADCY9/RHOA/ADCY2/RUNX2/GNA13/GNAQ/ADCY5/GNA11/PDE4A/MEF2D/CREB1/SP1/LRP5/CREB3L2/MAFB/ATF6B/ATF4/CREB5/MMP16/MMP13/SOST/ITPR2/ITPR1/NACA/PDE4C
hsa04380	Osteoclast differentiation	68/3197	128/8019	0.00151077461094833	0.00497938978914602	0.00290471165799947	AKT3/PPARG/MAPK14/MAPK3/TGFB2/IL1B/TGFBR1/GRB2/MAPK1/AKT1/SOCS3/CSF1/TGFBR2/MAP2K6/MAP2K1/FOSB/FOSL1/JUNB/TGFB1/FOS/PPP3CA/TNF/MAPK10/TRAF6/NFATC2/JUN/STAT1/FHL2/MITF/SQSTM1/MAP3K7/RAC1/IKBKG/MAPK8/MAPK9/LILRA5/MAP2K7/TAB2/CYLD/FYN/CALCR/SIRPA/SYK/PIK3CB/PIK3R2/TAB1/BTK/AKT2/PIK3CA/CAMK4/TEC/CREB1/NFATC1/STAT2/IFNAR1/PIK3R1/ITGB3/GAB2/FOSL2/NFKB2/SOCS1/LILRB1/PLCG2/IFNB1/OSCAR/LILRA2/PPP3R1/IFNAR2	68	http://www.kegg.jp/kegg-bin/show_pathway?hsa04380/AKT3/PPARG/MAPK14/MAPK3/TGFB2/IL1B/TGFBR1/GRB2/MAPK1/AKT1/SOCS3/CSF1/TGFBR2/MAP2K6/MAP2K1/FOSB/FOSL1/JUNB/TGFB1/FOS/PPP3CA/TNF/MAPK10/TRAF6/NFATC2/JUN/STAT1/FHL2/MITF/SQSTM1/MAP3K7/RAC1/IKBKG/MAPK8/MAPK9/LILRA5/MAP2K7/TAB2/CYLD/FYN/CALCR/SIRPA/SYK/PIK3CB/PIK3R2/TAB1/BTK/AKT2/PIK3CA/CAMK4/TEC/CREB1/NFATC1/STAT2/IFNAR1/PIK3R1/ITGB3/GAB2/FOSL2/NFKB2/SOCS1/LILRB1/PLCG2/IFNB1/OSCAR/LILRA2/PPP3R1/IFNAR2
hsa04710	Circadian rhythm	21/3197	31/8019	0.00154577920275556	0.00504329982313176	0.00294199337898187	PRKAG1/CUL1/CSNK1E/FBXW11/CSNK1D/BTRC/SKP1/RBX1/PER2/PER3/CRY2/BHLHE40/PER1/FBXL3/PRKAA1/PRKAA2/CREB1/RORA/RORB/PRKAB1/PRKAB2	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa04710/PRKAG1/CUL1/CSNK1E/FBXW11/CSNK1D/BTRC/SKP1/RBX1/PER2/PER3/CRY2/BHLHE40/PER1/FBXL3/PRKAA1/PRKAA2/CREB1/RORA/RORB/PRKAB1/PRKAB2
hsa05217	Basal cell carcinoma	37/3197	63/8019	0.0018345231352974	0.00592550972701059	0.0034566278022972	TP53/BAK1/WNT9B/FZD5/LEF1/PTCH1/CTNNB1/WNT5A/GLI2/FZD4/WNT7A/GLI1/BAX/WNT4/WNT7B/GLI3/APC/GADD45A/CDKN1A/TCF7L2/BMP2/FZD8/SUFU/WNT16/DVL3/DVL2/FZD7/GSK3B/APC2/AXIN2/WNT8B/HHIP/FZD9/FZD1/WNT10A/FZD6/FZD2	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa05217/TP53/BAK1/WNT9B/FZD5/LEF1/PTCH1/CTNNB1/WNT5A/GLI2/FZD4/WNT7A/GLI1/BAX/WNT4/WNT7B/GLI3/APC/GADD45A/CDKN1A/TCF7L2/BMP2/FZD8/SUFU/WNT16/DVL3/DVL2/FZD7/GSK3B/APC2/AXIN2/WNT8B/HHIP/FZD9/FZD1/WNT10A/FZD6/FZD2
hsa04921	Oxytocin signaling pathway	79/3197	153/8019	0.00192967632382469	0.00617114309500372	0.00359991726904242	MAPK3/CCND1/PRKACB/KRAS/EGFR/PTGS2/MAPK1/MAP2K1/SRC/PRKAG1/RGS2/FOS/HRAS/CDKN1A/ACTB/PPP3CA/CAMK2A/CALM3/PPP1R12B/PPP1R12A/PPP1CB/NFATC2/MAP2K5/JUN/MEF2C/NFATC3/NRAS/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/CAMKK2/PIK3CG/MAPK7/CALM1/PRKCA/MAP2K2/PRKAA1/GNAS/PRKCB/ADCY9/RHOA/EEF2K/CAMK2G/ADCY2/NPR1/EEF2/MYLK3/ACTG1/GNAQ/ADCY5/PRKAA2/CAMK4/MYLK4/GUCY1A2/CAMK1D/NFATC1/CACNG7/CALM2/ELK1/CACNA1C/KCNJ3/KCNJ5/KCNJ2/PRKAB1/PRKAB2/ITPR2/ITPR1/PLA2G4A/PPP3R1/CACNG6/KCNJ12/CACNG1/CACNG8/KCNJ6/PPP1R12C/PLA2G4D/CALML4	79	http://www.kegg.jp/kegg-bin/show_pathway?hsa04921/MAPK3/CCND1/PRKACB/KRAS/EGFR/PTGS2/MAPK1/MAP2K1/SRC/PRKAG1/RGS2/FOS/HRAS/CDKN1A/ACTB/PPP3CA/CAMK2A/CALM3/PPP1R12B/PPP1R12A/PPP1CB/NFATC2/MAP2K5/JUN/MEF2C/NFATC3/NRAS/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/CAMKK2/PIK3CG/MAPK7/CALM1/PRKCA/MAP2K2/PRKAA1/GNAS/PRKCB/ADCY9/RHOA/EEF2K/CAMK2G/ADCY2/NPR1/EEF2/MYLK3/ACTG1/GNAQ/ADCY5/PRKAA2/CAMK4/MYLK4/GUCY1A2/CAMK1D/NFATC1/CACNG7/CALM2/ELK1/CACNA1C/KCNJ3/KCNJ5/KCNJ2/PRKAB1/PRKAB2/ITPR2/ITPR1/PLA2G4A/PPP3R1/CACNG6/KCNJ12/CACNG1/CACNG8/KCNJ6/PPP1R12C/PLA2G4D/CALML4
hsa04916	Melanogenesis	55/3197	101/8019	0.00199422822463548	0.00631505604467902	0.00368386844385708	MAPK3/WNT9B/PRKACB/KRAS/FZD5/LEF1/CTNNB1/MAPK1/WNT5A/KIT/EDN1/FZD4/MAP2K1/WNT7A/KITLG/WNT4/WNT7B/HRAS/EP300/CAMK2A/CALM3/TCF7L2/MITF/FZD8/CREBBP/CREB3/NRAS/GNAI3/GNAI2/WNT16/DVL3/CALM1/PRKCA/MAP2K2/DVL2/FZD7/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/GSK3B/GNAQ/ADCY5/CREB1/CREB3L2/CALM2/WNT8B/FZD9/FZD1/WNT10A/FZD6/FZD2/TYRP1/CALML4	55	http://www.kegg.jp/kegg-bin/show_pathway?hsa04916/MAPK3/WNT9B/PRKACB/KRAS/FZD5/LEF1/CTNNB1/MAPK1/WNT5A/KIT/EDN1/FZD4/MAP2K1/WNT7A/KITLG/WNT4/WNT7B/HRAS/EP300/CAMK2A/CALM3/TCF7L2/MITF/FZD8/CREBBP/CREB3/NRAS/GNAI3/GNAI2/WNT16/DVL3/CALM1/PRKCA/MAP2K2/DVL2/FZD7/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/GSK3B/GNAQ/ADCY5/CREB1/CREB3L2/CALM2/WNT8B/FZD9/FZD1/WNT10A/FZD6/FZD2/TYRP1/CALML4
hsa04666	Fc gamma R-mediated phagocytosis	51/3197	93/8019	0.00234315113549611	0.00734793996859459	0.0042863980915054	AKT3/MAPK3/PLPP3/MAPK1/AKT1/DNM2/CRKL/MAP2K1/PTPRC/RPS6KB1/RAC1/CDC42/ASAP2/MYO10/PAK1/PRKCD/CRK/SYK/PIK3CB/PRKCA/PIK3R2/LYN/PIP5K1A/AKT2/PRKCB/PIK3CA/ARF6/LIMK1/PLCG1/PIK3R1/WASF3/ARPC2/VASP/WASF2/GAB2/GSN/INPPL1/VAV2/VAV3/MARCKS/PLA2G4A/ASAP3/PLCG2/ARPC5/ASAP1/ARPC1B/ARPC4/ARPC5L/CFL2/MARCKSL1/PLA2G4D	51	http://www.kegg.jp/kegg-bin/show_pathway?hsa04666/AKT3/MAPK3/PLPP3/MAPK1/AKT1/DNM2/CRKL/MAP2K1/PTPRC/RPS6KB1/RAC1/CDC42/ASAP2/MYO10/PAK1/PRKCD/CRK/SYK/PIK3CB/PRKCA/PIK3R2/LYN/PIP5K1A/AKT2/PRKCB/PIK3CA/ARF6/LIMK1/PLCG1/PIK3R1/WASF3/ARPC2/VASP/WASF2/GAB2/GSN/INPPL1/VAV2/VAV3/MARCKS/PLA2G4A/ASAP3/PLCG2/ARPC5/ASAP1/ARPC1B/ARPC4/ARPC5L/CFL2/MARCKSL1/PLA2G4D
hsa05016	Huntington disease	131/3197	271/8019	0.00245517274702969	0.00762519997394799	0.00444813685949711	TP53/PPARGC1A/PPARG/CASP8/MTOR/VDAC2/BAX/TBP/SOD1/CASP3/TBPL1/HDAC2/ACTR1A/NDUFAB1/CLTC/BECN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/EP300/TUBB/DCTN3/TUBB4B/TUBA1A/SIN3A/SDHD/SDHA/SDHC/HDAC1/MAPK10/CREBBP/RCOR1/REST/TBPL2/ACTR1B/CREB3/CYCS/MAPK8/MAPK9/MAP2K7/MAP3K5/DLG4/KIF5B/TGM2/TUBB2B/KIF5C/KIF5A/DNAH3/POLR2D/DNAH9/GNAQ/NDUFS2/DNAH11/KCNJ10/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/APAF1/DNAH17/DNAL1/CREB1/POLR2B/SP1/AP2A1/SLC25A6/SOD2/PPIF/NDUFA7/ACTR10/NDUFC2/AP2B1/BBC3/AP2M1/POLR2E/POLR2F/POLR2A/VDAC1/DCTN4/DCTN5/DCTN6/CREB3L2/BDNF/CASP9/TFAM/NRF1/CREB5/SLC1A2/CYTB/ITPR1/ND4/NDUFA2/GRM5/NDUFS7/COX7A2L/KLC2/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/CLTB/ATP6/UQCRC1/COX5A/HIP1/NDUFV3/UQCR11/NDUFB6/NRBF2	131	http://www.kegg.jp/kegg-bin/show_pathway?hsa05016/TP53/PPARGC1A/PPARG/CASP8/MTOR/VDAC2/BAX/TBP/SOD1/CASP3/TBPL1/HDAC2/ACTR1A/NDUFAB1/CLTC/BECN1/RB1CC1/PIK3C3/ULK1/WIPI2/ATG14/ATG2A/AMBRA1/ATG2B/ULK2/EP300/TUBB/DCTN3/TUBB4B/TUBA1A/SIN3A/SDHD/SDHA/SDHC/HDAC1/MAPK10/CREBBP/RCOR1/REST/TBPL2/ACTR1B/CREB3/CYCS/MAPK8/MAPK9/MAP2K7/MAP3K5/DLG4/KIF5B/TGM2/TUBB2B/KIF5C/KIF5A/DNAH3/POLR2D/DNAH9/GNAQ/NDUFS2/DNAH11/KCNJ10/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/APAF1/DNAH17/DNAL1/CREB1/POLR2B/SP1/AP2A1/SLC25A6/SOD2/PPIF/NDUFA7/ACTR10/NDUFC2/AP2B1/BBC3/AP2M1/POLR2E/POLR2F/POLR2A/VDAC1/DCTN4/DCTN5/DCTN6/CREB3L2/BDNF/CASP9/TFAM/NRF1/CREB5/SLC1A2/CYTB/ITPR1/ND4/NDUFA2/GRM5/NDUFS7/COX7A2L/KLC2/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/CLTB/ATP6/UQCRC1/COX5A/HIP1/NDUFV3/UQCR11/NDUFB6/NRBF2
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	40/3197	70/8019	0.00248320148317003	0.00763880075298973	0.00445607083195425	MAPK14/EGFR/SRC/CASP3/ADAM10/PTPN11/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/ADAM17/MAPK10/JUN/RAC1/CDC42/IKBKG/MAP2K4/MAPK8/PAK1/CCL5/MAPK9/MET/HBEGF/LYN/PLCG1/CXCL8/F11R/CXCL1/CXCL3/PLCG2/TJP1/JAM2	40	http://www.kegg.jp/kegg-bin/show_pathway?hsa05120/MAPK14/EGFR/SRC/CASP3/ADAM10/PTPN11/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/ADAM17/MAPK10/JUN/RAC1/CDC42/IKBKG/MAP2K4/MAPK8/PAK1/CCL5/MAPK9/MET/HBEGF/LYN/PLCG1/CXCL8/F11R/CXCL1/CXCL3/PLCG2/TJP1/JAM2
hsa05164	Influenza A	86/3197	170/8019	0.002710638252549	0.00825977505257854	0.0048183142721576	AKT3/MAPK3/BAK1/IL1B/TNFSF10/CASP8/MAPK1/AKT1/SOCS3/ICAM1/MAP2K1/BAX/CASP3/KPNA6/KPNA1/KPNA2/RAB11B/XPO1/EP300/ACTB/CCND3/CDK4/BID/CCL2/CDK6/TNF/CIITA/STAT1/CREBBP/HLA-DRB1/NLRP3/HLA-DRB5/PYCARD/TLR7/IKBKG/CYCS/IRAK4/CCL5/FAS/TLR4/EIF2AK2/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/IL18/PABPN1/AKT2/PRKCB/PIK3CA/OAS2/OAS3/RNASEL/MX1/ACTG1/APAF1/TBK1/STAT2/SLC25A6/HLA-DOB/IFNAR1/NXF1/HNRNPUL1/NUP98/CPSF4/CALCOCO2/VDAC1/CXCL10/PIK3R1/CASP9/ADAR/TICAM1/CXCL8/IFNB1/TRAF3/MAVS/TNFRSF10B/TNFRSF10A/TRADD/IFNAR2/EIF2S1/TMPRSS4/KPNA5/NXT2/BCL2L2-PABPN1	86	http://www.kegg.jp/kegg-bin/show_pathway?hsa05164/AKT3/MAPK3/BAK1/IL1B/TNFSF10/CASP8/MAPK1/AKT1/SOCS3/ICAM1/MAP2K1/BAX/CASP3/KPNA6/KPNA1/KPNA2/RAB11B/XPO1/EP300/ACTB/CCND3/CDK4/BID/CCL2/CDK6/TNF/CIITA/STAT1/CREBBP/HLA-DRB1/NLRP3/HLA-DRB5/PYCARD/TLR7/IKBKG/CYCS/IRAK4/CCL5/FAS/TLR4/EIF2AK2/PIK3CB/JAK2/PRKCA/PIK3R2/MAP2K2/IL18/PABPN1/AKT2/PRKCB/PIK3CA/OAS2/OAS3/RNASEL/MX1/ACTG1/APAF1/TBK1/STAT2/SLC25A6/HLA-DOB/IFNAR1/NXF1/HNRNPUL1/NUP98/CPSF4/CALCOCO2/VDAC1/CXCL10/PIK3R1/CASP9/ADAR/TICAM1/CXCL8/IFNB1/TRAF3/MAVS/TNFRSF10B/TNFRSF10A/TRADD/IFNAR2/EIF2S1/TMPRSS4/KPNA5/NXT2/BCL2L2-PABPN1
hsa04611	Platelet activation	65/3197	124/8019	0.00291975545705782	0.00881384123952967	0.00514152707145449	AKT3/MAPK14/MAPK3/PRKACB/MAPK1/AKT1/SRC/ITGB1/ITGA2/P2RY1/ACTB/PPP1R12A/PPP1CB/ARHGAP35/RASGRP1/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/PIK3CG/FGB/RAP1B/FYN/FGA/SYK/PIK3CB/PIK3R2/RAP1A/LYN/FGG/GNAS/BTK/AKT2/ADCY9/RHOA/PIK3CA/PRKG2/ADCY2/PRKG1/GNA13/MYLK3/ACTG1/GNAQ/ADCY5/MYLK4/GUCY1A2/COL1A1/VAMP8/PIK3R1/ITGB3/VASP/F2/COL1A2/COL3A1/TBXA2R/F2RL3/ITPR2/ITPR1/PLA2G4A/TLN1/PLCG2/MYL12A/GP5/PLA2G4D	65	http://www.kegg.jp/kegg-bin/show_pathway?hsa04611/AKT3/MAPK14/MAPK3/PRKACB/MAPK1/AKT1/SRC/ITGB1/ITGA2/P2RY1/ACTB/PPP1R12A/PPP1CB/ARHGAP35/RASGRP1/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/PIK3CG/FGB/RAP1B/FYN/FGA/SYK/PIK3CB/PIK3R2/RAP1A/LYN/FGG/GNAS/BTK/AKT2/ADCY9/RHOA/PIK3CA/PRKG2/ADCY2/PRKG1/GNA13/MYLK3/ACTG1/GNAQ/ADCY5/MYLK4/GUCY1A2/COL1A1/VAMP8/PIK3R1/ITGB3/VASP/F2/COL1A2/COL3A1/TBXA2R/F2RL3/ITPR2/ITPR1/PLA2G4A/TLN1/PLCG2/MYL12A/GP5/PLA2G4D
hsa03030	DNA replication	23/3197	36/8019	0.00301062713442036	0.00900400522609052	0.00525245864582109	DNA2/RPA1/PCNA/RNASEH2B/RPA3/POLE3/POLA2/MCM4/MCM3/MCM5/POLE/MCM2/PRIM1/PRIM2/MCM7/RFC1/RFC2/LIG1/POLD4/POLD2/FEN1/POLD3/RNASEH1	23	http://www.kegg.jp/kegg-bin/show_pathway?hsa03030/DNA2/RPA1/PCNA/RNASEH2B/RPA3/POLE3/POLA2/MCM4/MCM3/MCM5/POLE/MCM2/PRIM1/PRIM2/MCM7/RFC1/RFC2/LIG1/POLD4/POLD2/FEN1/POLD3/RNASEH1
hsa05221	Acute myeloid leukemia	38/3197	67/8019	0.00376427615987431	0.0111546899049486	0.00650705391228876	AKT3/MAPK3/CCND1/RARA/KRAS/LEF1/GRB2/MTOR/MAPK1/SOS1/AKT1/KIT/MAP2K1/PPARD/STAT3/HRAS/CCNA2/MYC/RPS6KB1/EIF4EBP1/TCF7L2/RUNX1/PER2/NRAS/IKBKG/DUSP6/BRAF/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/PIM1/SOS2/PIK3R1/STAT5A/JUP/RUNX1T1	38	http://www.kegg.jp/kegg-bin/show_pathway?hsa05221/AKT3/MAPK3/CCND1/RARA/KRAS/LEF1/GRB2/MTOR/MAPK1/SOS1/AKT1/KIT/MAP2K1/PPARD/STAT3/HRAS/CCNA2/MYC/RPS6KB1/EIF4EBP1/TCF7L2/RUNX1/PER2/NRAS/IKBKG/DUSP6/BRAF/PIK3CB/PIK3R2/MAP2K2/AKT2/PIK3CA/PIM1/SOS2/PIK3R1/STAT5A/JUP/RUNX1T1
hsa04725	Cholinergic synapse	59/3197	112/8019	0.00385604322492584	0.0112207383932527	0.00654558309399455	AKT3/MAPK3/PRKACB/KRAS/BCL2/MAPK1/AKT1/MAP2K1/FOS/HRAS/CAMK2A/CREB3/NRAS/GNAI3/CACNA1A/GNAI2/PIK3CG/FYN/PIK3CB/JAK2/PRKCA/PIK3R2/AKT2/PRKCB/ADCY9/PIK3CA/CAMK2G/ADCY2/GNAQ/ADCY5/CAMK4/GNA11/CREB1/KCNQ1/GNB4/GNB2/CREB3L2/PIK3R1/CHRNB2/ATF4/CREB5/GNG2/CHRM2/CHRNA6/CACNA1C/KCNJ3/KCNJ2/GNG4/ITPR2/ITPR1/GNG12/CHRM3/KCNJ12/GNB5/KCNJ6/GNG5/KCNQ2/KCNQ5/KCNQ3	59	http://www.kegg.jp/kegg-bin/show_pathway?hsa04725/AKT3/MAPK3/PRKACB/KRAS/BCL2/MAPK1/AKT1/MAP2K1/FOS/HRAS/CAMK2A/CREB3/NRAS/GNAI3/CACNA1A/GNAI2/PIK3CG/FYN/PIK3CB/JAK2/PRKCA/PIK3R2/AKT2/PRKCB/ADCY9/PIK3CA/CAMK2G/ADCY2/GNAQ/ADCY5/CAMK4/GNA11/CREB1/KCNQ1/GNB4/GNB2/CREB3L2/PIK3R1/CHRNB2/ATF4/CREB5/GNG2/CHRM2/CHRNA6/CACNA1C/KCNJ3/KCNJ2/GNG4/ITPR2/ITPR1/GNG12/CHRM3/KCNJ12/GNB5/KCNJ6/GNG5/KCNQ2/KCNQ5/KCNQ3
hsa05145	Toxoplasmosis	59/3197	112/8019	0.00385604322492584	0.0112207383932527	0.00654558309399455	AKT3/MAPK14/MAPK3/TGFB2/BCL2/CASP8/MAPK1/AKT1/BCL2L1/MAP2K6/ITGB1/HSPA2/BIRC3/BIRC2/CASP3/TGFB1/STAT3/CD40/TNF/MAPK10/HSPA1A/CIITA/TRAF6/STAT1/MAP3K7/HLA-DRB1/HLA-DRB5/GNAI3/IKBKG/CYCS/GNAI2/MAPK8/CCR5/IRAK4/CD40LG/PIK3CG/IRAK1/MAPK9/TLR4/TAB2/JAK2/TAB1/MAP2K3/PDPK1/HSPA1B/AKT2/HSPA8/HSPA6/XIAP/PPIF/HLA-DOB/LDLR/LAMA2/LAMC1/CASP9/SOCS1/TLR2/LAMA4/IL10RB	59	http://www.kegg.jp/kegg-bin/show_pathway?hsa05145/AKT3/MAPK14/MAPK3/TGFB2/BCL2/CASP8/MAPK1/AKT1/BCL2L1/MAP2K6/ITGB1/HSPA2/BIRC3/BIRC2/CASP3/TGFB1/STAT3/CD40/TNF/MAPK10/HSPA1A/CIITA/TRAF6/STAT1/MAP3K7/HLA-DRB1/HLA-DRB5/GNAI3/IKBKG/CYCS/GNAI2/MAPK8/CCR5/IRAK4/CD40LG/PIK3CG/IRAK1/MAPK9/TLR4/TAB2/JAK2/TAB1/MAP2K3/PDPK1/HSPA1B/AKT2/HSPA8/HSPA6/XIAP/PPIF/HLA-DOB/LDLR/LAMA2/LAMC1/CASP9/SOCS1/TLR2/LAMA4/IL10RB
hsa05142	Chagas disease (American trypanosomiasis)	54/3197	102/8019	0.00485426186666336	0.0139993444904666	0.00816647438094681	AKT3/MAPK14/MAPK3/TGFB2/IL1B/TGFBR1/CASP8/MAPK1/AKT1/TGFBR2/PPP2R1A/CALR/TGFB1/FOS/CCL2/PPP2R2A/TNF/MAPK10/TRAF6/JUN/SMAD2/GNAI3/IKBKG/PPP2R2D/PPP2R1B/PPP2CB/MAP2K4/GNAI2/MAPK8/IRAK4/CCL5/FAS/IRAK1/MAPK9/TLR4/TLR6/PIK3CB/PIK3R2/GNAS/AKT2/PIK3CA/GNAQ/GNA11/GNAL/C3/PIK3R1/TLR2/SERPINE1/TICAM1/CXCL8/BDKRB2/CD3G/IFNB1/CD3D	54	http://www.kegg.jp/kegg-bin/show_pathway?hsa05142/AKT3/MAPK14/MAPK3/TGFB2/IL1B/TGFBR1/CASP8/MAPK1/AKT1/TGFBR2/PPP2R1A/CALR/TGFB1/FOS/CCL2/PPP2R2A/TNF/MAPK10/TRAF6/JUN/SMAD2/GNAI3/IKBKG/PPP2R2D/PPP2R1B/PPP2CB/MAP2K4/GNAI2/MAPK8/IRAK4/CCL5/FAS/IRAK1/MAPK9/TLR4/TLR6/PIK3CB/PIK3R2/GNAS/AKT2/PIK3CA/GNAQ/GNA11/GNAL/C3/PIK3R1/TLR2/SERPINE1/TICAM1/CXCL8/BDKRB2/CD3G/IFNB1/CD3D
hsa05020	Prion diseases	22/3197	35/8019	0.00493767643943746	0.0141138892914894	0.00823329373692879	MAPK3/IL1B/PRKACB/MAPK1/EGR1/MAP2K1/BAX/NOTCH1/SOD1/HSPA5/HSPA1A/NCAM1/CCL5/FYN/MAP2K2/LAMC1/ELK1/C6/PRNP/C8A/NCAM2/STIP1	22	http://www.kegg.jp/kegg-bin/show_pathway?hsa05020/MAPK3/IL1B/PRKACB/MAPK1/EGR1/MAP2K1/BAX/NOTCH1/SOD1/HSPA5/HSPA1A/NCAM1/CCL5/FYN/MAP2K2/LAMC1/ELK1/C6/PRNP/C8A/NCAM2/STIP1
hsa04530	Tight junction	84/3197	169/8019	0.00555966904919918	0.0157523956393977	0.00918911135555543	CCND1/MYH9/PRKACB/CFTR/SRC/ITGB1/ACTR2/PPP2R1A/STK11/RAB13/PRKAG1/YBX3/PCNA/ACTB/CDK4/RDX/PPP2R2A/TUBA1A/MAPK10/JUN/RUNX1/EZR/ARHGEF2/RAC1/CDC42/ROCK1/RAB8A/WHAMM/MYH14/MYH2/PPP2R2D/PPP2R1B/PPP2CB/RAPGEF2/MAPK8/ERBB2/ROCK2/NF2/MAPK9/MAP2K7/DLG3/MAP3K5/RAP1A/TIAM1/PRKAA1/MYH11/RHOA/RAB8B/RAP2C/BVES/ACTG1/ACTR3B/PRKAA2/TUBA1B/TUBA1C/TUBAL3/HSPA4/PARD6B/PARD3/ARHGEF18/ACTN4/VASP/ACTN1/MSN/CLDN1/AMOT/AMOTL1/AMOTL2/F11R/PRKAB1/PRKAB2/EPB41L4B/MYL12A/TJP1/MARVELD2/MPP5/JAM2/CLDN16/TJAP1/CLDN7/CLDN23/TJP3/PATJ/CGN	84	http://www.kegg.jp/kegg-bin/show_pathway?hsa04530/CCND1/MYH9/PRKACB/CFTR/SRC/ITGB1/ACTR2/PPP2R1A/STK11/RAB13/PRKAG1/YBX3/PCNA/ACTB/CDK4/RDX/PPP2R2A/TUBA1A/MAPK10/JUN/RUNX1/EZR/ARHGEF2/RAC1/CDC42/ROCK1/RAB8A/WHAMM/MYH14/MYH2/PPP2R2D/PPP2R1B/PPP2CB/RAPGEF2/MAPK8/ERBB2/ROCK2/NF2/MAPK9/MAP2K7/DLG3/MAP3K5/RAP1A/TIAM1/PRKAA1/MYH11/RHOA/RAB8B/RAP2C/BVES/ACTG1/ACTR3B/PRKAA2/TUBA1B/TUBA1C/TUBAL3/HSPA4/PARD6B/PARD3/ARHGEF18/ACTN4/VASP/ACTN1/MSN/CLDN1/AMOT/AMOTL1/AMOTL2/F11R/PRKAB1/PRKAB2/EPB41L4B/MYL12A/TJP1/MARVELD2/MPP5/JAM2/CLDN16/TJAP1/CLDN7/CLDN23/TJP3/PATJ/CGN
hsa04929	GnRH secretion	36/3197	64/8019	0.00568629911876409	0.015971083611833	0.00931668230900477	AKT3/MAPK3/KRAS/ARRB1/MAPK1/AKT1/MAP2K1/ARRB2/TRPC4/TRPC1/HRAS/ESR2/NRAS/GPER1/PIK3CB/PRKCA/PIK3R2/MAP2K2/AKT2/PRKCB/PIK3CA/GNAQ/KCNJ11/GNA11/HCN2/PIK3R1/CACNA1C/KCNJ3/KCNJ5/ITPR2/ITPR1/KCNN4/KCNN1/KCNJ6/GABBR2/KCNN3	36	http://www.kegg.jp/kegg-bin/show_pathway?hsa04929/AKT3/MAPK3/KRAS/ARRB1/MAPK1/AKT1/MAP2K1/ARRB2/TRPC4/TRPC1/HRAS/ESR2/NRAS/GPER1/PIK3CB/PRKCA/PIK3R2/MAP2K2/AKT2/PRKCB/PIK3CA/GNAQ/KCNJ11/GNA11/HCN2/PIK3R1/CACNA1C/KCNJ3/KCNJ5/ITPR2/ITPR1/KCNN4/KCNN1/KCNJ6/GABBR2/KCNN3
hsa04728	Dopaminergic synapse	67/3197	132/8019	0.00684929177177848	0.0190717348472797	0.0111254376329251	AKT3/MAPK14/PRKACB/ARRB1/AKT1/ARRB2/PPP2R1A/COMT/FOS/ATF2/PPP3CA/CAMK2A/CALM3/PPP2R2A/PPP1CB/MAPK10/CREB3/GNAI3/CACNA1A/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/GNAI2/MAPK8/MAPK9/CALM1/PRKCA/GNAS/KIF5B/AKT2/PRKCB/KIF5C/CAMK2G/KIF5A/GSK3B/GNAQ/ADCY5/GNAL/PPP2R3C/CREB1/GNB4/GNB2/CREB3L2/CALM2/ATF6B/ATF4/CREB5/GNG2/DDC/MAOA/GRIN2A/LRTOMT/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR2/ITPR1/GNG12/GNB5/KCNJ6/GNG5/CALML4	67	http://www.kegg.jp/kegg-bin/show_pathway?hsa04728/AKT3/MAPK14/PRKACB/ARRB1/AKT1/ARRB2/PPP2R1A/COMT/FOS/ATF2/PPP3CA/CAMK2A/CALM3/PPP2R2A/PPP1CB/MAPK10/CREB3/GNAI3/CACNA1A/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/GNAI2/MAPK8/MAPK9/CALM1/PRKCA/GNAS/KIF5B/AKT2/PRKCB/KIF5C/CAMK2G/KIF5A/GSK3B/GNAQ/ADCY5/GNAL/PPP2R3C/CREB1/GNB4/GNB2/CREB3L2/CALM2/ATF6B/ATF4/CREB5/GNG2/DDC/MAOA/GRIN2A/LRTOMT/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR2/ITPR1/GNG12/GNB5/KCNJ6/GNG5/CALML4
hsa05110	Vibrio cholerae infection	29/3197	50/8019	0.00706398675182893	0.0195014335114593	0.0113761010218388	PRKACB/CFTR/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/ACTB/ARF1/KDELR1/KDELR2/PRKCA/GNAS/ADCY9/ACTG1/KCNQ1/PLCG1/SEC61A1/ERO1A/PLCG2/TJP1/SEC61B	29	http://www.kegg.jp/kegg-bin/show_pathway?hsa05110/PRKACB/CFTR/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/ACTB/ARF1/KDELR1/KDELR2/PRKCA/GNAS/ADCY9/ACTG1/KCNQ1/PLCG1/SEC61A1/ERO1A/PLCG2/TJP1/SEC61B
hsa04930	Type II diabetes mellitus	27/3197	46/8019	0.00741254454465028	0.0202902702366275	0.0118362664896735	MAPK3/MTOR/MAPK1/SOCS3/TNF/MAPK10/CACNA1A/MAPK8/ADIPOQ/PRKCD/MAPK9/IRS2/PIK3CB/PIK3R2/IRS1/HK1/PIK3CA/GCK/PKM/HK2/KCNJ11/PIK3R1/SOCS1/CACNA1C/SOCS4/CACNA1E/IRS4	27	http://www.kegg.jp/kegg-bin/show_pathway?hsa04930/MAPK3/MTOR/MAPK1/SOCS3/TNF/MAPK10/CACNA1A/MAPK8/ADIPOQ/PRKCD/MAPK9/IRS2/PIK3CB/PIK3R2/IRS1/HK1/PIK3CA/GCK/PKM/HK2/KCNJ11/PIK3R1/SOCS1/CACNA1C/SOCS4/CACNA1E/IRS4
hsa04370	VEGF signaling pathway	33/3197	59/8019	0.00888179887432826	0.0241077398017481	0.0140631755727975	AKT3/MAPK14/MAPK3/KRAS/VEGFA/PTGS2/MAPK1/AKT1/MAP2K1/SRC/HRAS/PPP3CA/NFATC2/RAC1/CDC42/NRAS/KDR/PIK3CB/PRKCA/PIK3R2/MAP2K2/MAPKAPK2/AKT2/PRKCB/PIK3CA/PXN/PLCG1/PIK3R1/CASP9/PLA2G4A/PLCG2/PPP3R1/PLA2G4D	33	http://www.kegg.jp/kegg-bin/show_pathway?hsa04370/AKT3/MAPK14/MAPK3/KRAS/VEGFA/PTGS2/MAPK1/AKT1/MAP2K1/SRC/HRAS/PPP3CA/NFATC2/RAC1/CDC42/NRAS/KDR/PIK3CB/PRKCA/PIK3R2/MAP2K2/MAPKAPK2/AKT2/PRKCB/PIK3CA/PXN/PLCG1/PIK3R1/CASP9/PLA2G4A/PLCG2/PPP3R1/PLA2G4D
hsa04022	cGMP-PKG signaling pathway	82/3197	167/8019	0.0090227919648849	0.0242863483721485	0.014167366330828	AKT3/MEF2A/MAPK3/MAPK1/AKT1/VDAC2/MAP2K1/ADRA2B/NPPC/ATP2B4/RGS2/ATF2/PPP3CA/CALM3/PPP1R12A/PPP1CB/NFATC2/MEF2C/SRF/NFATC3/CREB3/CNGB1/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/PIK3CG/IRS2/CALM1/MAP2K2/IRS1/GNA12/AKT2/ADCY9/RHOA/ATP1A2/PRKG2/ADCY2/NPR1/ATP2A2/PRKG1/GNA13/MYLK3/GNAQ/ADCY5/ATP2B1/GNA11/MYLK4/GUCY1A2/MEF2D/CREB1/NFATC1/SLC25A6/SLC8A1/PPIF/VDAC1/CREB3L2/VASP/CALM2/ATF6B/ATF4/CREB5/KCNMB1/KCNMB4/CACNA1C/KCNJ8/PDE3B/NPPB/EDNRA/ADORA3/BDKRB2/OPRD1/ITPR2/ITPR1/SLC8A3/ATP1B3/PPP3R1/FXYD2/IRS4/ATP1B4/CALML4	82	http://www.kegg.jp/kegg-bin/show_pathway?hsa04022/AKT3/MEF2A/MAPK3/MAPK1/AKT1/VDAC2/MAP2K1/ADRA2B/NPPC/ATP2B4/RGS2/ATF2/PPP3CA/CALM3/PPP1R12A/PPP1CB/NFATC2/MEF2C/SRF/NFATC3/CREB3/CNGB1/ROCK1/GNAI3/PPP1CC/GNAI2/ROCK2/PIK3CG/IRS2/CALM1/MAP2K2/IRS1/GNA12/AKT2/ADCY9/RHOA/ATP1A2/PRKG2/ADCY2/NPR1/ATP2A2/PRKG1/GNA13/MYLK3/GNAQ/ADCY5/ATP2B1/GNA11/MYLK4/GUCY1A2/MEF2D/CREB1/NFATC1/SLC25A6/SLC8A1/PPIF/VDAC1/CREB3L2/VASP/CALM2/ATF6B/ATF4/CREB5/KCNMB1/KCNMB4/CACNA1C/KCNJ8/PDE3B/NPPB/EDNRA/ADORA3/BDKRB2/OPRD1/ITPR2/ITPR1/SLC8A3/ATP1B3/PPP3R1/FXYD2/IRS4/ATP1B4/CALML4
hsa03013	RNA transport	87/3197	179/8019	0.0101776945257504	0.0271685564613006	0.0158486935198723	NUP62/EIF2B2/SENP2/EIF2B5/NDC1/ALYREF/XPOT/EIF2S3/EEF1A1/XPO5/RAN/XPO1/TPR/SEH1L/KPNB1/DDX39B/THOC5/EIF4E/EIF4G1/EIF4EBP1/UBE2I/SUMO1/EIF5/EIF4A2/EIF4A3/EIF4A1/POP4/RPP25/POP5/POP7/RPP30/CASC3/RNPS1/RBM8A/PABPC1/MAGOH/THOC2/GEMIN6/NUP214/EIF4G3/EIF3D/NXF1/GEMIN8/NUP98/PNN/GEMIN4/TGS1/FMR1/NUP37/NUP85/RANGAP1/NUP43/CYFIP2/ELAC2/RPP40/RPP14/NUP155/SUMO2/EIF4G2/NUP93/EIF4B/EIF3B/EIF3H/EIF3I/EIF3C/EIF2B3/ACIN1/PABPC4/EIF4EBP2/POM121/EIF2S1/NUP50/NUP58/PABPC1L2B/PABPC1L2A/EIF1AX/PABPC4L/POM121C/FXR1/NUP205/NUP35/PHAX/PABPC3/NUP54/NUP210/EIF1/NXT2	87	http://www.kegg.jp/kegg-bin/show_pathway?hsa03013/NUP62/EIF2B2/SENP2/EIF2B5/NDC1/ALYREF/XPOT/EIF2S3/EEF1A1/XPO5/RAN/XPO1/TPR/SEH1L/KPNB1/DDX39B/THOC5/EIF4E/EIF4G1/EIF4EBP1/UBE2I/SUMO1/EIF5/EIF4A2/EIF4A3/EIF4A1/POP4/RPP25/POP5/POP7/RPP30/CASC3/RNPS1/RBM8A/PABPC1/MAGOH/THOC2/GEMIN6/NUP214/EIF4G3/EIF3D/NXF1/GEMIN8/NUP98/PNN/GEMIN4/TGS1/FMR1/NUP37/NUP85/RANGAP1/NUP43/CYFIP2/ELAC2/RPP40/RPP14/NUP155/SUMO2/EIF4G2/NUP93/EIF4B/EIF3B/EIF3H/EIF3I/EIF3C/EIF2B3/ACIN1/PABPC4/EIF4EBP2/POM121/EIF2S1/NUP50/NUP58/PABPC1L2B/PABPC1L2A/EIF1AX/PABPC4L/POM121C/FXR1/NUP205/NUP35/PHAX/PABPC3/NUP54/NUP210/EIF1/NXT2
hsa04114	Oocyte meiosis	64/3197	128/8019	0.0121963979908178	0.0320386360755891	0.0186896394248996	MAPK14/BUB1/MAPK3/AR/PLK1/PRKACB/CDC25C/ESPL1/MAPK1/SMC3/CCNE2/CCNE1/MAP2K1/CDK2/PPP2R1A/IGF1/SMC1A/SGO1/CCNB1/AURKA/MAD2L2/CDC27/CDC23/ANAPC11/MAD2L1/ANAPC1/CUL1/PPP3CA/CAMK2A/YWHAE/FBXW11/CALM3/BTRC/SKP1/PPP1CB/RBX1/YWHAG/CPEB3/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/IGF1R/YWHAB/CALM1/RPS6KA2/ADCY9/CAMK2G/ADCY2/RPS6KA3/ADCY5/SLK/CPEB2/CPEB4/YWHAH/CALM2/ITPR2/ITPR1/YWHAZ/PPP3R1/YWHAQ/CALML4	64	http://www.kegg.jp/kegg-bin/show_pathway?hsa04114/MAPK14/BUB1/MAPK3/AR/PLK1/PRKACB/CDC25C/ESPL1/MAPK1/SMC3/CCNE2/CCNE1/MAP2K1/CDK2/PPP2R1A/IGF1/SMC1A/SGO1/CCNB1/AURKA/MAD2L2/CDC27/CDC23/ANAPC11/MAD2L1/ANAPC1/CUL1/PPP3CA/CAMK2A/YWHAE/FBXW11/CALM3/BTRC/SKP1/PPP1CB/RBX1/YWHAG/CPEB3/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/IGF1R/YWHAB/CALM1/RPS6KA2/ADCY9/CAMK2G/ADCY2/RPS6KA3/ADCY5/SLK/CPEB2/CPEB4/YWHAH/CALM2/ITPR2/ITPR1/YWHAZ/PPP3R1/YWHAQ/CALML4
hsa03430	Mismatch repair	15/3197	23/8019	0.0122783580129585	0.0320386360755891	0.0186896394248996	MLH1/MSH2/EXO1/MLH3/MSH6/MSH3/RPA1/PCNA/RPA3/RFC1/RFC2/LIG1/POLD4/POLD2/POLD3	15	http://www.kegg.jp/kegg-bin/show_pathway?hsa03430/MLH1/MSH2/EXO1/MLH3/MSH6/MSH3/RPA1/PCNA/RPA3/RFC1/RFC2/LIG1/POLD4/POLD2/POLD3
hsa04730	Long-term depression	33/3197	60/8019	0.0122996621466658	0.0320386360755891	0.0186896394248996	MAPK3/KRAS/MAPK1/MAP2K1/PPP2R1A/IGF1/HRAS/NRAS/GNAI3/CACNA1A/PPP2R1B/PPP2CB/BRAF/GNAI2/IGF1R/PRKCA/MAP2K2/LYN/GNA12/GNAS/PRKCB/PRKG2/PRKG1/GNA13/NOS1/GNAQ/GNA11/GNAZ/GUCY1A2/ITPR2/ITPR1/PLA2G4A/PLA2G4D	33	http://www.kegg.jp/kegg-bin/show_pathway?hsa04730/MAPK3/KRAS/MAPK1/MAP2K1/PPP2R1A/IGF1/HRAS/NRAS/GNAI3/CACNA1A/PPP2R1B/PPP2CB/BRAF/GNAI2/IGF1R/PRKCA/MAP2K2/LYN/GNA12/GNAS/PRKCB/PRKG2/PRKG1/GNA13/NOS1/GNAQ/GNA11/GNAZ/GUCY1A2/ITPR2/ITPR1/PLA2G4A/PLA2G4D
hsa04714	Thermogenesis	109/3197	231/8019	0.0131092697422545	0.0338743530139857	0.0197604992325353	PPARGC1A/PPARG/MAPK14/PRKACB/RPS6/KRAS/ACSL4/GRB2/MTOR/SOS1/SMARCA2/FRS2/PRKAG1/ARID1A/NDUFAB1/COX17/HRAS/ATF2/ACTB/RPS6KB1/SDHD/SDHA/SDHC/SMARCA4/PRDM16/FGFR1/ACTL6A/DPF3/DPF1/CREB3/NRAS/BMP8A/MAP3K5/MAP2K3/BMP8B/PRKAA1/GNAS/ACSL6/RPS6KA2/ADCY9/ACSL3/ACSL1/PRKG2/ADCY2/NPR1/RPS6KA3/PRKG1/ACTG1/ADCY5/NDUFS2/PRKAA2/CREB1/SMARCD2/ARID1B/SMARCD1/SMARCB1/SMARCC2/COX10/NDUFA7/NDUFC2/SOS2/CREB3L2/CREB5/CPT1A/NPPB/PRKAB1/PRKAB2/CYTB/ND4/NDUFA2/AKT1S1/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/CPT1C/NDUFA5/CYC1/NDUFS1/UQCRB/COX18/PNPLA2/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX19/COX2/CPT1B/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/NDUFAF3/ATP6/UQCRC1/COX5A/PLIN1/NDUFV3/UQCR11/COX20/NDUFB6/NDUFAF7/COA5/COA7	109	http://www.kegg.jp/kegg-bin/show_pathway?hsa04714/PPARGC1A/PPARG/MAPK14/PRKACB/RPS6/KRAS/ACSL4/GRB2/MTOR/SOS1/SMARCA2/FRS2/PRKAG1/ARID1A/NDUFAB1/COX17/HRAS/ATF2/ACTB/RPS6KB1/SDHD/SDHA/SDHC/SMARCA4/PRDM16/FGFR1/ACTL6A/DPF3/DPF1/CREB3/NRAS/BMP8A/MAP3K5/MAP2K3/BMP8B/PRKAA1/GNAS/ACSL6/RPS6KA2/ADCY9/ACSL3/ACSL1/PRKG2/ADCY2/NPR1/RPS6KA3/PRKG1/ACTG1/ADCY5/NDUFS2/PRKAA2/CREB1/SMARCD2/ARID1B/SMARCD1/SMARCB1/SMARCC2/COX10/NDUFA7/NDUFC2/SOS2/CREB3L2/CREB5/CPT1A/NPPB/PRKAB1/PRKAB2/CYTB/ND4/NDUFA2/AKT1S1/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/CPT1C/NDUFA5/CYC1/NDUFS1/UQCRB/COX18/PNPLA2/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX19/COX2/CPT1B/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/NDUFAF3/ATP6/UQCRC1/COX5A/PLIN1/NDUFV3/UQCR11/COX20/NDUFB6/NDUFAF7/COA5/COA7
hsa04064	NF-kappa B signaling pathway	53/3197	104/8019	0.0136865303978521	0.0350591647583769	0.0204516555051311	PARP1/IL1B/PTGS2/BCL2/ICAM1/BCL2L1/ATM/BIRC3/BIRC2/CD40/GADD45A/TNFAIP3/CSNK2A1/TNF/TRAF6/UBE2I/PIAS4/MAP3K7/ERC1/IKBKG/IRAK4/CD40LG/IRAK1/EDA2R/TLR4/TAB2/CYLD/SYK/TAB1/TIRAP/LYN/EDAR/BTK/PRKCB/XIAP/BCL10/TNFSF14/PLCG1/CXCL12/NFKB2/TICAM1/CXCL8/CARD10/MALT1/CXCL1/CXCL3/VCAM1/PLCG2/TNFSF13B/TNFRSF13C/TRAF3/TRADD/TRAF1	53	http://www.kegg.jp/kegg-bin/show_pathway?hsa04064/PARP1/IL1B/PTGS2/BCL2/ICAM1/BCL2L1/ATM/BIRC3/BIRC2/CD40/GADD45A/TNFAIP3/CSNK2A1/TNF/TRAF6/UBE2I/PIAS4/MAP3K7/ERC1/IKBKG/IRAK4/CD40LG/IRAK1/EDA2R/TLR4/TAB2/CYLD/SYK/TAB1/TIRAP/LYN/EDAR/BTK/PRKCB/XIAP/BCL10/TNFSF14/PLCG1/CXCL12/NFKB2/TICAM1/CXCL8/CARD10/MALT1/CXCL1/CXCL3/VCAM1/PLCG2/TNFSF13B/TNFRSF13C/TRAF3/TRADD/TRAF1
hsa04662	B cell receptor signaling pathway	43/3197	82/8019	0.0137848728306931	0.0350591647583769	0.0204516555051311	AKT3/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K1/FOS/HRAS/PTPN6/PPP3CA/NFATC2/JUN/NFATC3/RAC1/NRAS/IKBKG/RASGRP3/LILRA5/SYK/PIK3CB/PIK3R2/MAP2K2/LYN/BTK/AKT2/PRKCB/PIK3CA/GSK3B/NFATC1/BCL10/SOS2/PIK3R1/LILRB1/INPPL1/IFITM1/VAV2/VAV3/MALT1/PLCG2/LILRA2/PPP3R1	43	http://www.kegg.jp/kegg-bin/show_pathway?hsa04662/AKT3/MAPK3/KRAS/GRB2/MAPK1/SOS1/AKT1/MAP2K1/FOS/HRAS/PTPN6/PPP3CA/NFATC2/JUN/NFATC3/RAC1/NRAS/IKBKG/RASGRP3/LILRA5/SYK/PIK3CB/PIK3R2/MAP2K2/LYN/BTK/AKT2/PRKCB/PIK3CA/GSK3B/NFATC1/BCL10/SOS2/PIK3R1/LILRB1/INPPL1/IFITM1/VAV2/VAV3/MALT1/PLCG2/LILRA2/PPP3R1
hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	10/3197	14/8019	0.0169854700177941	0.0428617719980272	0.0250032823452725	B4GALT1/ST3GAL2/CHST6/CHST2/FUT8/B4GALT2/ST3GAL1/CHST1/CHST4/B3GNT2	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00533/B4GALT1/ST3GAL2/CHST6/CHST2/FUT8/B4GALT2/ST3GAL1/CHST1/CHST4/B3GNT2
hsa03018	RNA degradation	41/3197	79/8019	0.0196221164616865	0.0491313458691841	0.0286606189036466	DDX6/TOB2/DHX36/BTG1/ENO4/ENO1/EXOSC6/BTG2/CNOT4/CNOT6/CNOT6L/CNOT1/CNOT10/PFKP/HSPA9/SKIV2L/PFKM/HSPD1/EXOSC10/NUDT16/EXOSC2/DIS3L/PAN2/EXOSC1/C1D/PABPC1/DCP1A/DCP2/BTG3/WDR61/EDC3/TTC37/DCPS/PATL1/LSM3/LSM8/PABPC4/PABPC1L2B/PABPC1L2A/PABPC4L/PABPC3	41	http://www.kegg.jp/kegg-bin/show_pathway?hsa03018/DDX6/TOB2/DHX36/BTG1/ENO4/ENO1/EXOSC6/BTG2/CNOT4/CNOT6/CNOT6L/CNOT1/CNOT10/PFKP/HSPA9/SKIV2L/PFKM/HSPD1/EXOSC10/NUDT16/EXOSC2/DIS3L/PAN2/EXOSC1/C1D/PABPC1/DCP1A/DCP2/BTG3/WDR61/EDC3/TTC37/DCPS/PATL1/LSM3/LSM8/PABPC4/PABPC1L2B/PABPC1L2A/PABPC4L/PABPC3
hsa01230	Biosynthesis of amino acids	39/3197	75/8019	0.0216767686815277	0.0536181029417799	0.0312779547876115	ALDOA/ENO4/ENO1/CPS1/ASS1/CBS/CTH/PRPS1L1/PFKP/GLUL/IDH3A/PGK1/PFKM/IDH2/GAPDH/PRPS1/PHGDH/PKM/IDH3B/MAT2A/ASNS/PSPH/GOT1/SHMT1/SHMT2/ALDOC/PGAM1/ACO1/TPI1/MAT2B/TKT/CS/BCAT2/PSAT1/ACY1/GPT2/TAT/PGAM4/ABHD14A-ACY1	39	http://www.kegg.jp/kegg-bin/show_pathway?hsa01230/ALDOA/ENO4/ENO1/CPS1/ASS1/CBS/CTH/PRPS1L1/PFKP/GLUL/IDH3A/PGK1/PFKM/IDH2/GAPDH/PRPS1/PHGDH/PKM/IDH3B/MAT2A/ASNS/PSPH/GOT1/SHMT1/SHMT2/ALDOC/PGAM1/ACO1/TPI1/MAT2B/TKT/CS/BCAT2/PSAT1/ACY1/GPT2/TAT/PGAM4/ABHD14A-ACY1
hsa00270	Cysteine and methionine metabolism	27/3197	49/8019	0.0217460417503813	0.0536181029417799	0.0312779547876115	DNMT3A/AHCY/CBS/APIP/CTH/ENOPH1/BHMT2/MTAP/AHCYL1/SMS/AHCYL2/MRI1/GCLM/DNMT1/DNMT3B/LDHA/LDHB/PHGDH/MAT2A/GOT1/MAT2B/SRM/MDH2/BCAT2/PSAT1/AMD1/TAT	27	http://www.kegg.jp/kegg-bin/show_pathway?hsa00270/DNMT3A/AHCY/CBS/APIP/CTH/ENOPH1/BHMT2/MTAP/AHCYL1/SMS/AHCYL2/MRI1/GCLM/DNMT1/DNMT3B/LDHA/LDHB/PHGDH/MAT2A/GOT1/MAT2B/SRM/MDH2/BCAT2/PSAT1/AMD1/TAT
hsa03420	Nucleotide excision repair	26/3197	47/8019	0.0226836902463539	0.055506302648275	0.0323794302559597	RAD23B/ERCC1/ERCC4/RPA1/PCNA/XPC/CUL4A/CDK7/GTF2H1/RPA3/POLE3/POLE/RBX1/ERCC8/XPA/RFC1/DDB1/RFC2/LIG1/GTF2H5/POLD4/POLD2/POLD3/GTF2H2C/GTF2H3/RAD23A	26	http://www.kegg.jp/kegg-bin/show_pathway?hsa03420/RAD23B/ERCC1/ERCC4/RPA1/PCNA/XPC/CUL4A/CDK7/GTF2H1/RPA3/POLE3/POLE/RBX1/ERCC8/XPA/RFC1/DDB1/RFC2/LIG1/GTF2H5/POLD4/POLD2/POLD3/GTF2H2C/GTF2H3/RAD23A
hsa04720	Long-term potentiation	35/3197	67/8019	0.0264720146591805	0.0642891784580098	0.0375028937395592	MAPK3/PRKACB/KRAS/MAPK1/MAP2K1/HRAS/EP300/PPP3CA/CAMK2A/CALM3/PPP1CB/CREBBP/NRAS/PPP1CC/BRAF/RAP1B/CALM1/PRKCA/MAP2K2/RAP1A/RPS6KA2/PRKCB/CAMK2G/RPS6KA3/GNAQ/CAMK4/CALM2/ATF4/GRIN2A/CACNA1C/ITPR2/ITPR1/PPP3R1/GRM5/CALML4	35	http://www.kegg.jp/kegg-bin/show_pathway?hsa04720/MAPK3/PRKACB/KRAS/MAPK1/MAP2K1/HRAS/EP300/PPP3CA/CAMK2A/CALM3/PPP1CB/CREBBP/NRAS/PPP1CC/BRAF/RAP1B/CALM1/PRKCA/MAP2K2/RAP1A/RPS6KA2/PRKCB/CAMK2G/RPS6KA3/GNAQ/CAMK4/CALM2/ATF4/GRIN2A/CACNA1C/ITPR2/ITPR1/PPP3R1/GRM5/CALML4
hsa03010	Ribosome	73/3197	153/8019	0.0283208120596088	0.0682658380242809	0.039822665818303	RPS6/RPL29/RPL12/RPL23A/RPL10/RPL24/RPL5/RPL3/RPLP0/RPL3L/RPS27/RPS5/RPS14/RPS15/RPSA/RPS19/RPL26/UBA52/RPS27A/RPL23/RPS3/RPS8/RPL21/RPL30/RPS16/RPS17/RPL13A/RPL22/RPS21/RPS24/RPS2/RPS26/RPL41/RPS4X/RPS4Y1/RPL15/RPL36A/RPL9/RPL35/RPL13/RPS12/RPL10A/RPLP1/RPL37/RPL14/RPL19/RPL31/RPL27A/RPS23/RPS7/RPS15A/RPL36/RPL8/RPL37A/RPL7/RPL7A/RPL4/RPL18A/RPL28/MRPL23/MRPL34/MRPS12/MRPL12/MRPL21/MRPS10/MRPS15/MRPL17/MRPS14/MRPS21/MRPS16/MRPS5/RPL36AL/RPL17-C18orf32	73	http://www.kegg.jp/kegg-bin/show_pathway?hsa03010/RPS6/RPL29/RPL12/RPL23A/RPL10/RPL24/RPL5/RPL3/RPLP0/RPL3L/RPS27/RPS5/RPS14/RPS15/RPSA/RPS19/RPL26/UBA52/RPS27A/RPL23/RPS3/RPS8/RPL21/RPL30/RPS16/RPS17/RPL13A/RPL22/RPS21/RPS24/RPS2/RPS26/RPL41/RPS4X/RPS4Y1/RPL15/RPL36A/RPL9/RPL35/RPL13/RPS12/RPL10A/RPLP1/RPL37/RPL14/RPL19/RPL31/RPL27A/RPS23/RPS7/RPS15A/RPL36/RPL8/RPL37A/RPL7/RPL7A/RPL4/RPL18A/RPL28/MRPL23/MRPL34/MRPS12/MRPL12/MRPL21/MRPS10/MRPS15/MRPL17/MRPS14/MRPS21/MRPS16/MRPS5/RPL36AL/RPL17-C18orf32
hsa04670	Leukocyte transendothelial migration	55/3197	112/8019	0.028650907389591	0.0685499487913919	0.0399884009570121	MAPK14/CTNNA1/MMP2/CTNNB1/ICAM1/ITGB1/MMP9/PTPN11/ACTB/ARHGAP35/EZR/RAC1/CDC42/ROCK1/GNAI3/GNAI2/ROCK2/CXCR4/RAP1B/PIK3CB/PRKCA/PIK3R2/RAP1A/PRKCB/RHOA/PIK3CA/TXK/RHOH/ACTG1/CYBB/PXN/PLCG1/VCL/PIK3R1/CXCL12/ACTN4/VASP/ACTN1/MSN/CLDN1/CTNNA3/VAV2/VAV3/BCAR1/F11R/VCAM1/PLCG2/MYL12A/JAM2/CD99/CLDN16/CLDN7/RASSF5/CLDN23/CTNND1	55	http://www.kegg.jp/kegg-bin/show_pathway?hsa04670/MAPK14/CTNNA1/MMP2/CTNNB1/ICAM1/ITGB1/MMP9/PTPN11/ACTB/ARHGAP35/EZR/RAC1/CDC42/ROCK1/GNAI3/GNAI2/ROCK2/CXCR4/RAP1B/PIK3CB/PRKCA/PIK3R2/RAP1A/PRKCB/RHOA/PIK3CA/TXK/RHOH/ACTG1/CYBB/PXN/PLCG1/VCL/PIK3R1/CXCL12/ACTN4/VASP/ACTN1/MSN/CLDN1/CTNNA3/VAV2/VAV3/BCAR1/F11R/VCAM1/PLCG2/MYL12A/JAM2/CD99/CLDN16/CLDN7/RASSF5/CLDN23/CTNND1
hsa00310	Lysine degradation	32/3197	61/8019	0.0307704379202754	0.073079790060654	0.0426308698740657	ASH1L/KMT2B/KMT2D/NSD2/HADHA/DOT1L/EZH2/SUV39H2/EHMT2/NSD1/EHMT1/EZH1/SUV39H1/KMT5A/SMYD2/ALDH1B1/ALDH2/SETD1A/NSD3/PRDM2/KMT2A/PRDM6/ALDH9A1/PLOD2/SETD7/DHTKD1/KMT2C/COLGALT1/SMYD1/DLST/SETD1B/TMLHE	32	http://www.kegg.jp/kegg-bin/show_pathway?hsa00310/ASH1L/KMT2B/KMT2D/NSD2/HADHA/DOT1L/EZH2/SUV39H2/EHMT2/NSD1/EHMT1/EZH1/SUV39H1/KMT5A/SMYD2/ALDH1B1/ALDH2/SETD1A/NSD3/PRDM2/KMT2A/PRDM6/ALDH9A1/PLOD2/SETD7/DHTKD1/KMT2C/COLGALT1/SMYD1/DLST/SETD1B/TMLHE
hsa04914	Progesterone-mediated oocyte maturation	49/3197	99/8019	0.0319716485237102	0.075378412212835	0.0439717640087908	AKT3/CDC25B/MAPK14/BUB1/MAPK3/PLK1/PRKACB/CDC25C/KRAS/FZR1/MAPK1/AKT1/HSP90AB1/CDC25A/MAP2K1/CDK2/IGF1/CCNB1/AURKA/MAD2L2/CDC27/CDC23/ANAPC11/MAD2L1/ANAPC1/CCNA2/HSP90AA1/MAPK10/CPEB3/GNAI3/BRAF/GNAI2/MAPK8/IGF1R/MAPK9/PIK3CB/PIK3R2/AKT2/RPS6KA2/ADCY9/PIK3CA/ADCY2/RPS6KA3/STK10/ADCY5/CPEB2/CPEB4/PIK3R1/PDE3B	49	http://www.kegg.jp/kegg-bin/show_pathway?hsa04914/AKT3/CDC25B/MAPK14/BUB1/MAPK3/PLK1/PRKACB/CDC25C/KRAS/FZR1/MAPK1/AKT1/HSP90AB1/CDC25A/MAP2K1/CDK2/IGF1/CCNB1/AURKA/MAD2L2/CDC27/CDC23/ANAPC11/MAD2L1/ANAPC1/CCNA2/HSP90AA1/MAPK10/CPEB3/GNAI3/BRAF/GNAI2/MAPK8/IGF1R/MAPK9/PIK3CB/PIK3R2/AKT2/RPS6KA2/ADCY9/PIK3CA/ADCY2/RPS6KA3/STK10/ADCY5/CPEB2/CPEB4/PIK3R1/PDE3B
hsa03060	Protein export	14/3197	23/8019	0.0337117654368137	0.0789050741745713	0.0460290313744444	HSPA5/IMMP2L/SRPRB/SRPRA/SEC61A1/SRP14/SEC63/OXA1L/SEC61B/SRP19/SPCS3/SPCS1/SRP68/SRP9	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa03060/HSPA5/IMMP2L/SRPRB/SRPRA/SEC61A1/SRP14/SEC63/OXA1L/SEC61B/SRP19/SPCS3/SPCS1/SRP68/SRP9
hsa04962	Vasopressin-regulated water reabsorption	24/3197	44/8019	0.0340964903944797	0.0792314129310573	0.0462194000803625	PRKACB/RAB11B/RAB5A/DYNC1LI1/DYNC1H1/NSF/CREB3/STX4/VAMP2/GNAS/ADCY9/RAB5B/RAB5C/DYNC1LI2/CREB1/DCTN4/DCTN5/DCTN6/CREB3L2/ARHGDIA/CREB5/AQP3/DYNLL2/DYNC2LI1	24	http://www.kegg.jp/kegg-bin/show_pathway?hsa04962/PRKACB/RAB11B/RAB5A/DYNC1LI1/DYNC1H1/NSF/CREB3/STX4/VAMP2/GNAS/ADCY9/RAB5B/RAB5C/DYNC1LI2/CREB1/DCTN4/DCTN5/DCTN6/CREB3L2/ARHGDIA/CREB5/AQP3/DYNLL2/DYNC2LI1
hsa04216	Ferroptosis	22/3197	40/8019	0.0373494554185794	0.086170529287151	0.0502673121798926	TP53/ATG7/ACSL4/VDAC2/NCOA4/TFRC/SLC39A14/FTH1/FTL/STEAP3/MAP1LC3B/GCLM/SLC7A11/ACSL6/ACSL3/ACSL1/CYBB/PCBP1/PCBP2/SAT1/PRNP/LPCAT3	22	http://www.kegg.jp/kegg-bin/show_pathway?hsa04216/TP53/ATG7/ACSL4/VDAC2/NCOA4/TFRC/SLC39A14/FTH1/FTL/STEAP3/MAP1LC3B/GCLM/SLC7A11/ACSL6/ACSL3/ACSL1/CYBB/PCBP1/PCBP2/SAT1/PRNP/LPCAT3
hsa04072	Phospholipase D signaling pathway	70/3197	148/8019	0.0384532651761437	0.0880879762545703	0.0513858489475903	AKT3/MAPK3/KRAS/EGFR/PLPP3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/KIT/PDGFB/DNM2/AVPR1A/MAP2K1/PDGFRB/KITLG/PTPN11/HRAS/NRAS/PDGFA/ARF1/PDGFD/CYTH2/PDGFC/CYTH3/AGPAT3/PIK3CG/SHC3/RRAS/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNA12/PIP5K1A/GNAS/AKT2/DGKG/ADCY9/RHOA/DGKE/PIK3CA/DGKD/MRAS/ADCY2/ARF6/GNA13/DGKH/RRAS2/DNM1/ADCY5/SOS2/PLCG1/PIK3R1/GAB2/F2/CXCL8/PLA2G4A/PLCG2/GRM5/AGPAT5/SHC4/AGPAT4/RALGDS/LPAR2/PLA2G4D	70	http://www.kegg.jp/kegg-bin/show_pathway?hsa04072/AKT3/MAPK3/KRAS/EGFR/PLPP3/GRB2/PDGFRA/MTOR/MAPK1/SOS1/AKT1/KIT/PDGFB/DNM2/AVPR1A/MAP2K1/PDGFRB/KITLG/PTPN11/HRAS/NRAS/PDGFA/ARF1/PDGFD/CYTH2/PDGFC/CYTH3/AGPAT3/PIK3CG/SHC3/RRAS/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/GNA12/PIP5K1A/GNAS/AKT2/DGKG/ADCY9/RHOA/DGKE/PIK3CA/DGKD/MRAS/ADCY2/ARF6/GNA13/DGKH/RRAS2/DNM1/ADCY5/SOS2/PLCG1/PIK3R1/GAB2/F2/CXCL8/PLA2G4A/PLCG2/GRM5/AGPAT5/SHC4/AGPAT4/RALGDS/LPAR2/PLA2G4D
hsa05416	Viral myocarditis	31/3197	60/8019	0.0419352347734517	0.0953878931818655	0.0556442329462406	CCND1/CASP8/ICAM1/CASP3/CXADR/CD40/CD28/ACTB/BID/EIF4G1/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD55/ABL1/CYCS/CD40LG/FYN/DAG1/ABL2/ACTG1/HLA-DOB/EIF4G3/LAMA2/CASP9/DMD/EIF4G2	31	http://www.kegg.jp/kegg-bin/show_pathway?hsa05416/CCND1/CASP8/ICAM1/CASP3/CXADR/CD40/CD28/ACTB/BID/EIF4G1/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD55/ABL1/CYCS/CD40LG/FYN/DAG1/ABL2/ACTG1/HLA-DOB/EIF4G3/LAMA2/CASP9/DMD/EIF4G2
hsa04142	Lysosome	61/3197	128/8019	0.0432755738991227	0.0977483242616548	0.0570211831280307	CTSB/PSAP/CTSV/PSAPL1/SPAM1/IGF2R/CLTC/ATP6AP1/ATP6V0D1/ATP6V0A2/CTNS/SCARB2/AP1S2/AP1G1/ENTPD4/GNPTG/CTSZ/AP1B1/AP3D1/AP4E1/AP1S1/LITAF/M6PR/AP4S1/AP1S3/SORT1/NAGPA/CTSC/GNPTAB/ABCB9/ABCA2/LGMN/GNS/IDS/CD164/GALNS/CTSA/GM2A/LAMP1/AP3M1/HEXA/SGSH/ARSB/GLA/LAPTM4A/MFSD8/LIPA/HGSNAT/ARSA/DNASE2/GALC/GUSB/TPP1/LAPTM4B/AP3B1/CLTB/GGA2/GGA1/GGA3/AP3S2/AP3M2	61	http://www.kegg.jp/kegg-bin/show_pathway?hsa04142/CTSB/PSAP/CTSV/PSAPL1/SPAM1/IGF2R/CLTC/ATP6AP1/ATP6V0D1/ATP6V0A2/CTNS/SCARB2/AP1S2/AP1G1/ENTPD4/GNPTG/CTSZ/AP1B1/AP3D1/AP4E1/AP1S1/LITAF/M6PR/AP4S1/AP1S3/SORT1/NAGPA/CTSC/GNPTAB/ABCB9/ABCA2/LGMN/GNS/IDS/CD164/GALNS/CTSA/GM2A/LAMP1/AP3M1/HEXA/SGSH/ARSB/GLA/LAPTM4A/MFSD8/LIPA/HGSNAT/ARSA/DNASE2/GALC/GUSB/TPP1/LAPTM4B/AP3B1/CLTB/GGA2/GGA1/GGA3/AP3S2/AP3M2
hsa05133	Pertussis	38/3197	76/8019	0.0460811174108113	0.103362506414528	0.0602961989512809	MAPK14/MAPK3/IL1B/MAPK1/ITGA5/ITGB1/CASP3/FOS/CALM3/TNF/MAPK10/TRAF6/JUN/IRF8/NLRP3/PYCARD/GNAI3/GNAI2/MAPK8/IRAK4/IRAK1/MAPK9/TLR4/CALM1/TIRAP/RHOA/IRF1/C3/CALM2/TICAM1/CXCL8/SFTPA1/CXCL5/SERPING1/C1S/CFL2/CASP7/CALML4	38	http://www.kegg.jp/kegg-bin/show_pathway?hsa05133/MAPK14/MAPK3/IL1B/MAPK1/ITGA5/ITGB1/CASP3/FOS/CALM3/TNF/MAPK10/TRAF6/JUN/IRF8/NLRP3/PYCARD/GNAI3/GNAI2/MAPK8/IRAK4/IRAK1/MAPK9/TLR4/CALM1/TIRAP/RHOA/IRF1/C3/CALM2/TICAM1/CXCL8/SFTPA1/CXCL5/SERPING1/C1S/CFL2/CASP7/CALML4
hsa05410	Hypertrophic cardiomyopathy (HCM)	44/3197	90/8019	0.0504932736630985	0.112478119952971	0.0656137639614855	TGFB2/EDN1/ITGA5/ITGB1/IGF1/ITGB8/ITGA3/ITGA2/PRKAG1/TGFB1/TTN/ACTB/TNF/ITGA1/DAG1/PRKAA1/ACTC1/ATP2A2/ACTG1/PRKAA2/LMNA/EMD/TPM1/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/TNNI3/ITGB4/PRKAB1/PRKAB2/SLC8A3/TPM3/TNNC1/ITGA9/TPM2/CACNG6/CACNG1/CACNG8	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa05410/TGFB2/EDN1/ITGA5/ITGB1/IGF1/ITGB8/ITGA3/ITGA2/PRKAG1/TGFB1/TTN/ACTB/TNF/ITGA1/DAG1/PRKAA1/ACTC1/ATP2A2/ACTG1/PRKAA2/LMNA/EMD/TPM1/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/TNNI3/ITGB4/PRKAB1/PRKAB2/SLC8A3/TPM3/TNNC1/ITGA9/TPM2/CACNG6/CACNG1/CACNG8
hsa04620	Toll-like receptor signaling pathway	50/3197	104/8019	0.0535090104808142	0.118379523187007	0.0690563293155425	AKT3/MAPK14/MAPK3/IL1B/CASP8/MAPK1/AKT1/MAP2K6/MAP2K1/FOS/CD40/TNF/MAPK10/TRAF6/JUN/STAT1/MAP3K7/RAC1/TLR7/IKBKG/MAP2K4/MAPK8/IRAK4/CCL5/MAP3K8/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/TLR6/PIK3CB/PIK3R2/MAP2K2/TAB1/TIRAP/MAP2K3/AKT2/PIK3CA/TBK1/IFNAR1/CXCL10/PIK3R1/TLR2/TICAM1/CXCL8/IFNB1/TRAF3/TLR5/IFNAR2	50	http://www.kegg.jp/kegg-bin/show_pathway?hsa04620/AKT3/MAPK14/MAPK3/IL1B/CASP8/MAPK1/AKT1/MAP2K6/MAP2K1/FOS/CD40/TNF/MAPK10/TRAF6/JUN/STAT1/MAP3K7/RAC1/TLR7/IKBKG/MAP2K4/MAPK8/IRAK4/CCL5/MAP3K8/IRAK1/MAPK9/TLR4/MAP2K7/TAB2/TLR6/PIK3CB/PIK3R2/MAP2K2/TAB1/TIRAP/MAP2K3/AKT2/PIK3CA/TBK1/IFNAR1/CXCL10/PIK3R1/TLR2/TICAM1/CXCL8/IFNB1/TRAF3/TLR5/IFNAR2
hsa01200	Carbon metabolism	55/3197	117/8019	0.068400642487294	0.149605491601433	0.0872719015696806	ACOX1/ALDOA/ENO4/ENO1/CPS1/HADHA/ALDH6A1/MTHFR/SDHD/SDHA/SDHC/GLUD2/HK1/PRPS1L1/PFKP/IDH3A/PCCB/PGK1/SUCLG2/PFKM/IDH2/PGD/GAPDH/G6PD/PRPS1/PHGDH/GCK/PKM/GLUD1/IDH3B/HK2/IDNK/PCCA/PSPH/GOT1/SHMT1/SHMT2/ADH5/ALDOC/PGAM1/ACO1/TPI1/MDH2/PDHA1/TKT/PDHB/PGLS/CS/PSAT1/DLAT/OGDH/GPT2/DLST/PGAM4/ESD	55	http://www.kegg.jp/kegg-bin/show_pathway?hsa01200/ACOX1/ALDOA/ENO4/ENO1/CPS1/HADHA/ALDH6A1/MTHFR/SDHD/SDHA/SDHC/GLUD2/HK1/PRPS1L1/PFKP/IDH3A/PCCB/PGK1/SUCLG2/PFKM/IDH2/PGD/GAPDH/G6PD/PRPS1/PHGDH/GCK/PKM/GLUD1/IDH3B/HK2/IDNK/PCCA/PSPH/GOT1/SHMT1/SHMT2/ADH5/ALDOC/PGAM1/ACO1/TPI1/MDH2/PDHA1/TKT/PDHB/PGLS/CS/PSAT1/DLAT/OGDH/GPT2/DLST/PGAM4/ESD
hsa04392	Hippo signaling pathway - multiple species	16/3197	29/8019	0.0686039013371534	0.149605491601433	0.0872719015696806	STK3/LATS2/CSNK1E/WWC1/WWTR1/PAK1/NF2/RASSF2/YAP1/FRMD6/WTIP/LIMD1/TEAD1/MOB1B/MOB1A/RASSF4	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa04392/STK3/LATS2/CSNK1E/WWC1/WWTR1/PAK1/NF2/RASSF2/YAP1/FRMD6/WTIP/LIMD1/TEAD1/MOB1B/MOB1A/RASSF4
hsa04145	Phagosome	70/3197	152/8019	0.0690130595932307	0.149605491601433	0.0872719015696806	ITGA5/ITGB1/CALR/ITGA2/TFRC/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/PIK3C3/PIKFYVE/RAB5A/STX12/DYNC1LI1/ACTB/TUBB/TUBB4B/TUBA1A/DYNC1H1/CD36/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/HLA-E/HLA-DRB5/VAMP3/M6PR/STX7/THBS1/TLR4/TLR6/HGS/RAB5B/TUBB2B/RAB5C/NOS1/ACTG1/CYBB/DYNC1LI2/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/HLA-DOB/SCARB1/LAMP1/C3/ITGB3/CORO1A/TLR2/THBS2/SFTPA1/MSR1/SEC61A1/OLR1/COLEC12/CANX/EEA1/SEC61B	70	http://www.kegg.jp/kegg-bin/show_pathway?hsa04145/ITGA5/ITGB1/CALR/ITGA2/TFRC/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/PIK3C3/PIKFYVE/RAB5A/STX12/DYNC1LI1/ACTB/TUBB/TUBB4B/TUBA1A/DYNC1H1/CD36/HLA-A/HLA-DRB1/RAC1/HLA-B/HLA-C/HLA-E/HLA-DRB5/VAMP3/M6PR/STX7/THBS1/TLR4/TLR6/HGS/RAB5B/TUBB2B/RAB5C/NOS1/ACTG1/CYBB/DYNC1LI2/TUBB1/TUBB2A/TUBA1B/TUBA1C/TUBAL3/HLA-DOB/SCARB1/LAMP1/C3/ITGB3/CORO1A/TLR2/THBS2/SFTPA1/MSR1/SEC61A1/OLR1/COLEC12/CANX/EEA1/SEC61B
hsa05031	Amphetamine addiction	34/3197	69/8019	0.0705018374049209	0.151813956545263	0.0885602027753041	SIRT1/PRKACB/FOSB/HDAC2/FOS/ATF2/PPP3CA/CAMK2A/CALM3/PPP1CB/HDAC1/JUN/CREB3/PPP1CC/CALM1/PRKCA/GNAS/PRKCB/CAMK2G/ADCY5/CAMK4/CREB1/CREB3L2/ARC/CALM2/ATF6B/ATF4/CREB5/DDC/MAOA/GRIN2A/CACNA1C/PPP3R1/CALML4	34	http://www.kegg.jp/kegg-bin/show_pathway?hsa05031/SIRT1/PRKACB/FOSB/HDAC2/FOS/ATF2/PPP3CA/CAMK2A/CALM3/PPP1CB/HDAC1/JUN/CREB3/PPP1CC/CALM1/PRKCA/GNAS/PRKCB/CAMK2G/ADCY5/CAMK4/CREB1/CREB3L2/ARC/CALM2/ATF6B/ATF4/CREB5/DDC/MAOA/GRIN2A/CACNA1C/PPP3R1/CALML4
hsa04024	cAMP signaling pathway	97/3197	216/8019	0.0723306258198348	0.154720477747064	0.0902557129435373	AKT3/MAPK3/ACOX1/PRKACB/PTCH1/MAPK1/AKT1/EDN1/SSTR2/MAP2K1/SOX9/CFTR/ADCYAP1R1/GLI1/ADCYAP1/MC2R/ATP2B4/GLI3/FOS/AMH/EP300/CAMK2A/CALM3/PPP1R12A/PPP1CB/MAPK10/JUN/PPARA/CREBBP/RAC1/CREB3/CNGB1/ROCK1/CNGA2/PLCE1/GNAI3/PPP1CC/BRAF/GNAI2/MAPK8/ROCK2/PAK1/MAPK9/EDN3/RRAS/RAP1B/CALM1/PIK3CB/PIK3R2/MAP2K2/RAP1A/TIAM1/GNAS/AKT2/ADCY9/RHOA/PDE10A/PIK3CA/ATP1A2/CAMK2G/ADCY2/NPR1/ATP2A2/HCN4/RRAS2/ADCY5/ATP2B1/CAMK4/PDE4A/HCN2/CREB1/NFATC1/CREB3L2/PIK3R1/BDNF/CALM2/CREB5/HHIP/GRIN2A/CHRM2/CACNA1C/PDE3B/VAV2/VAV3/EDNRA/TNNI3/GLP1R/PTGER3/ATP1B3/HCAR2/FXYD2/ATP1B4/GABBR2/PDE4C/HCAR1/CALML4/HTR1F	97	http://www.kegg.jp/kegg-bin/show_pathway?hsa04024/AKT3/MAPK3/ACOX1/PRKACB/PTCH1/MAPK1/AKT1/EDN1/SSTR2/MAP2K1/SOX9/CFTR/ADCYAP1R1/GLI1/ADCYAP1/MC2R/ATP2B4/GLI3/FOS/AMH/EP300/CAMK2A/CALM3/PPP1R12A/PPP1CB/MAPK10/JUN/PPARA/CREBBP/RAC1/CREB3/CNGB1/ROCK1/CNGA2/PLCE1/GNAI3/PPP1CC/BRAF/GNAI2/MAPK8/ROCK2/PAK1/MAPK9/EDN3/RRAS/RAP1B/CALM1/PIK3CB/PIK3R2/MAP2K2/RAP1A/TIAM1/GNAS/AKT2/ADCY9/RHOA/PDE10A/PIK3CA/ATP1A2/CAMK2G/ADCY2/NPR1/ATP2A2/HCN4/RRAS2/ADCY5/ATP2B1/CAMK4/PDE4A/HCN2/CREB1/NFATC1/CREB3L2/PIK3R1/BDNF/CALM2/CREB5/HHIP/GRIN2A/CHRM2/CACNA1C/PDE3B/VAV2/VAV3/EDNRA/TNNI3/GLP1R/PTGER3/ATP1B3/HCAR2/FXYD2/ATP1B4/GABBR2/PDE4C/HCAR1/CALML4/HTR1F
hsa04971	Gastric acid secretion	37/3197	76/8019	0.0731461124309205	0.155435488915706	0.0906728125009332	PRKACB/SLC4A2/SSTR2/CFTR/ACTB/CAMK2A/CALM3/EZR/GNAI3/GNAI2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/MYLK3/ACTG1/GNAQ/ADCY5/KCNJ10/MYLK4/KCNQ1/CALM2/KCNJ2/ITPR2/KCNK2/ITPR1/ATP1B3/SLC9A4/SLC26A7/KCNK10/CHRM3/ATP1B4/CALML4	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa04971/PRKACB/SLC4A2/SSTR2/CFTR/ACTB/CAMK2A/CALM3/EZR/GNAI3/GNAI2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/MYLK3/ACTG1/GNAQ/ADCY5/KCNJ10/MYLK4/KCNQ1/CALM2/KCNJ2/ITPR2/KCNK2/ITPR1/ATP1B3/SLC9A4/SLC26A7/KCNK10/CHRM3/ATP1B4/CALML4
hsa04070	Phosphatidylinositol signaling system	47/3197	99/8019	0.0740655987698287	0.156360708514083	0.0912125364967275	PTEN/PLCD1/INPP5B/PLCD3/PIP4K2C/PIK3C3/PIKFYVE/MTMR3/CALM3/CDIPT/PLCE1/ITPKB/CALM1/PIK3CB/PRKCA/PIK3R2/PIP5K1A/PIK3C2A/DGKG/PRKCB/PPIP5K2/DGKE/PIK3CA/PIK3C2B/DGKD/PPIP5K1/IPPK/IPMK/DGKH/PI4K2B/IP6K1/PI4K2A/PIP4P2/PLCG1/PIK3R1/CALM2/INPPL1/ITPR2/ITPR1/OCRL/MTMR14/MTMR6/PLCG2/INPP4B/INPP5A/SYNJ2/CALML4	47	http://www.kegg.jp/kegg-bin/show_pathway?hsa04070/PTEN/PLCD1/INPP5B/PLCD3/PIP4K2C/PIK3C3/PIKFYVE/MTMR3/CALM3/CDIPT/PLCE1/ITPKB/CALM1/PIK3CB/PRKCA/PIK3R2/PIP5K1A/PIK3C2A/DGKG/PRKCB/PPIP5K2/DGKE/PIK3CA/PIK3C2B/DGKD/PPIP5K1/IPPK/IPMK/DGKH/PI4K2B/IP6K1/PI4K2A/PIP4P2/PLCG1/PIK3R1/CALM2/INPPL1/ITPR2/ITPR1/OCRL/MTMR14/MTMR6/PLCG2/INPP4B/INPP5A/SYNJ2/CALML4
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	37/3197	77/8019	0.0882213964347719	0.185035786028775	0.107940054421218	LEF1/CTNNA1/CTNNB1/ITGA5/ITGB1/ITGB8/GJA1/ITGA3/ITGA2/ACTB/TCF7L2/ITGA1/CDH2/DAG1/ACTN2/ATP2A2/ACTG1/LMNA/EMD/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/CTNNA3/JUP/PKP2/ITGB4/SLC8A3/ITGA9/CACNG6/CACNG1/CACNG8	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa05412/LEF1/CTNNA1/CTNNB1/ITGA5/ITGB1/ITGB8/GJA1/ITGA3/ITGA2/ACTB/TCF7L2/ITGA1/CDH2/DAG1/ACTN2/ATP2A2/ACTG1/LMNA/EMD/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/CTNNA3/JUP/PKP2/ITGB4/SLC8A3/ITGA9/CACNG6/CACNG1/CACNG8
hsa04979	Cholesterol metabolism	25/3197	50/8019	0.0938162844825968	0.194795184620433	0.113633169454318	APOB/VDAC2/STAR/SOAT1/CD36/VAPB/SORT1/ABCA1/APOE/ABCB11/ABCG8/MYLIP/SCARB1/LDLR/LIPA/PCSK9/VDAC1/LPL/APOH/ANGPTL3/LDLRAP1/LRPAP1/OSBPL5/LIPC/LIPG	25	http://www.kegg.jp/kegg-bin/show_pathway?hsa04979/APOB/VDAC2/STAR/SOAT1/CD36/VAPB/SORT1/ABCA1/APOE/ABCB11/ABCG8/MYLIP/SCARB1/LDLR/LIPA/PCSK9/VDAC1/LPL/APOH/ANGPTL3/LDLRAP1/LRPAP1/OSBPL5/LIPC/LIPG
hsa00020	Citrate cycle (TCA cycle)	16/3197	30/8019	0.0940806464420669	0.194795184620433	0.113633169454318	SDHD/SDHA/SDHC/IDH3A/SUCLG2/IDH2/PCK1/IDH3B/ACO1/MDH2/PDHA1/PDHB/CS/DLAT/OGDH/DLST	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa00020/SDHD/SDHA/SDHC/IDH3A/SUCLG2/IDH2/PCK1/IDH3B/ACO1/MDH2/PDHA1/PDHB/CS/DLAT/OGDH/DLST
hsa01212	Fatty acid metabolism	28/3197	57/8019	0.0982172003722095	0.202064686116074	0.117873810704831	ACOX1/ACSL4/ELOVL5/ELOVL7/ACSBG1/HACD4/ELOVL6/TECR/HACD3/ELOVL1/HADHA/ACADL/SCP2/ACADVL/ACSL6/ACACA/ACSL3/ACSL1/FASN/FADS1/CPT1A/SCD/ACAA2/HSD17B12/CPT1C/HADHB/CPT1B/SCD5	28	http://www.kegg.jp/kegg-bin/show_pathway?hsa01212/ACOX1/ACSL4/ELOVL5/ELOVL7/ACSBG1/HACD4/ELOVL6/TECR/HACD3/ELOVL1/HADHA/ACADL/SCP2/ACADVL/ACSL6/ACACA/ACSL3/ACSL1/FASN/FADS1/CPT1A/SCD/ACAA2/HSD17B12/CPT1C/HADHB/CPT1B/SCD5
hsa04657	IL-17 signaling pathway	44/3197	94/8019	0.101512115342184	0.207521602883073	0.121057086250839	MAPK14/MAPK3/IL1B/PTGS2/CASP8/MAPK1/HSP90AB1/FOSB/FOSL1/MMP9/CASP3/FOS/CEBPB/TNFAIP3/CCL2/HSP90AA1/TNF/MAPK10/TRAF6/JUN/MAP3K7/IKBKG/MAPK8/MAPK7/MAPK9/TAB2/TRAF4/MAPK6/HSP90B1/GSK3B/TBK1/SRSF1/CXCL10/MMP13/CXCL8/CXCL5/CXCL1/CXCL3/IL17RA/TRAF3IP2/TRAF3/TRADD/MMP1/USP25	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa04657/MAPK14/MAPK3/IL1B/PTGS2/CASP8/MAPK1/HSP90AB1/FOSB/FOSL1/MMP9/CASP3/FOS/CEBPB/TNFAIP3/CCL2/HSP90AA1/TNF/MAPK10/TRAF6/JUN/MAP3K7/IKBKG/MAPK8/MAPK7/MAPK9/TAB2/TRAF4/MAPK6/HSP90B1/GSK3B/TBK1/SRSF1/CXCL10/MMP13/CXCL8/CXCL5/CXCL1/CXCL3/IL17RA/TRAF3IP2/TRAF3/TRADD/MMP1/USP25
hsa04960	Aldosterone-regulated sodium reabsorption	19/3197	37/8019	0.104388501654068	0.212059660592855	0.123704348203099	MAPK3/KRAS/MAPK1/IGF1/SFN/PIK3CB/PRKCA/PIK3R2/IRS1/PDPK1/PRKCB/PIK3CA/ATP1A2/SGK1/PIK3R1/ATP1B3/FXYD2/SCNN1G/ATP1B4	19	http://www.kegg.jp/kegg-bin/show_pathway?hsa04960/MAPK3/KRAS/MAPK1/IGF1/SFN/PIK3CB/PRKCA/PIK3R2/IRS1/PDPK1/PRKCB/PIK3CA/ATP1A2/SGK1/PIK3R1/ATP1B3/FXYD2/SCNN1G/ATP1B4
hsa04261	Adrenergic signaling in cardiomyocytes	67/3197	149/8019	0.11573132408732	0.233632610501276	0.13628886191862	AKT3/MAPK14/MAPK3/PRKACB/BCL2/MAPK1/AKT1/CREM/PPP2R1A/ATP2B4/ATF2/CAMK2A/CALM3/PPP2R2A/PPP1CB/CREB3/GNAI3/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/GNAI2/PIK3CG/CALM1/PRKCA/GNAS/AKT2/ADCY9/ATP1A2/ACTC1/CAMK2G/ADCY2/ATP2A2/RPS6KA5/GNAQ/ADCY5/ATP2B1/PPP2R3C/CREB1/TPM1/SLC8A1/KCNQ1/CREB3L2/SCN1B/CACNG7/CALM2/ATF6B/ATF4/CREB5/CACNA1C/SCN4B/SCN7A/TNNI3/SLC8A3/ATP1B3/TPM3/FXYD2/TNNC1/TPM2/CACNG6/CACNG1/CACNG8/ATP1B4/CALML4	67	http://www.kegg.jp/kegg-bin/show_pathway?hsa04261/AKT3/MAPK14/MAPK3/PRKACB/BCL2/MAPK1/AKT1/CREM/PPP2R1A/ATP2B4/ATF2/CAMK2A/CALM3/PPP2R2A/PPP1CB/CREB3/GNAI3/PPP2R2D/PPP2R1B/PPP2R5C/PPP2R5D/PPP2R5E/PPP2CB/PPP1CC/GNAI2/PIK3CG/CALM1/PRKCA/GNAS/AKT2/ADCY9/ATP1A2/ACTC1/CAMK2G/ADCY2/ATP2A2/RPS6KA5/GNAQ/ADCY5/ATP2B1/PPP2R3C/CREB1/TPM1/SLC8A1/KCNQ1/CREB3L2/SCN1B/CACNG7/CALM2/ATF6B/ATF4/CREB5/CACNA1C/SCN4B/SCN7A/TNNI3/SLC8A3/ATP1B3/TPM3/FXYD2/TNNC1/TPM2/CACNG6/CACNG1/CACNG8/ATP1B4/CALML4
hsa03410	Base excision repair	17/3197	33/8019	0.117471521446688	0.23421791004494	0.136630294600112	PARP1/PCNA/POLE3/APEX1/POLE/HMGB1/LIG1/POLD4/POLD2/FEN1/POLD3/MBD4/OGG1/POLL/PARP2/APEX2/UNG	17	http://www.kegg.jp/kegg-bin/show_pathway?hsa03410/PARP1/PCNA/POLE3/APEX1/POLE/HMGB1/LIG1/POLD4/POLD2/FEN1/POLD3/MBD4/OGG1/POLL/PARP2/APEX2/UNG
hsa04130	SNARE interactions in vesicular transport	17/3197	33/8019	0.117471521446688	0.23421791004494	0.136630294600112	STX2/STX17/BET1L/GOSR1/STX6/VAMP4/VAMP3/VTI1A/STX16/YKT6/STX4/VAMP2/STX7/STX1B/STX3/VTI1B/VAMP8	17	http://www.kegg.jp/kegg-bin/show_pathway?hsa04130/STX2/STX17/BET1L/GOSR1/STX6/VAMP4/VAMP3/VTI1A/STX16/YKT6/STX4/VAMP2/STX7/STX1B/STX3/VTI1B/VAMP8
hsa04659	Th17 cell differentiation	49/3197	107/8019	0.123175192837348	0.244083357585664	0.142385272960189	MAPK14/MAPK3/IL1B/TGFBR1/RARA/MTOR/MAPK1/SMAD4/TGFBR2/RXRA/HSP90AB1/TGFB1/STAT3/FOS/HIF1A/FOXP3/PPP3CA/HSP90AA1/MAPK10/SMAD3/NFATC2/JUN/STAT1/RUNX1/SMAD2/NFATC3/HLA-DRB1/HLA-DRB5/IKBKG/MAPK8/MAPK9/IL2RB/IL2RA/JAK2/NFATC1/IRF4/HLA-DOB/PLCG1/RORA/STAT5A/AHR/IL6R/IL6ST/IL21R/CD3G/IL23R/CD3D/IL1RAP/PPP3R1	49	http://www.kegg.jp/kegg-bin/show_pathway?hsa04659/MAPK14/MAPK3/IL1B/TGFBR1/RARA/MTOR/MAPK1/SMAD4/TGFBR2/RXRA/HSP90AB1/TGFB1/STAT3/FOS/HIF1A/FOXP3/PPP3CA/HSP90AA1/MAPK10/SMAD3/NFATC2/JUN/STAT1/RUNX1/SMAD2/NFATC3/HLA-DRB1/HLA-DRB5/IKBKG/MAPK8/MAPK9/IL2RB/IL2RA/JAK2/NFATC1/IRF4/HLA-DOB/PLCG1/RORA/STAT5A/AHR/IL6R/IL6ST/IL21R/CD3G/IL23R/CD3D/IL1RAP/PPP3R1
hsa03020	RNA polymerase	16/3197	31/8019	0.124745858725062	0.245688490049969	0.143321622026868	POLR1B/POLR2D/POLR2B/POLR3G/POLR3D/POLR2E/POLR2F/POLR2A/POLR3A/POLR3H/POLR3K/POLR1D/POLR3E/TWISTNB/POLR1A/POLR3F	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa03020/POLR1B/POLR2D/POLR2B/POLR3G/POLR3D/POLR2E/POLR2F/POLR2A/POLR3A/POLR3H/POLR3K/POLR1D/POLR3E/TWISTNB/POLR1A/POLR3F
hsa04621	NOD-like receptor signaling pathway	80/3197	181/8019	0.13012401259561	0.25472761253565	0.148594566217635	MAPK14/MAPK3/IL1B/ANTXR1/BCL2/CTSB/CASP8/MAPK1/VDAC2/HSP90AB1/BCL2L1/ANTXR2/NAMPT/BIRC3/BIRC2/GABARAPL1/GABARAP/ATG12/MFN2/TNFAIP3/CCL2/YWHAE/HSP90AA1/TNF/MAPK10/TRAF6/JUN/STAT1/TXNIP/TXN/MAP3K7/NLRP3/DNM1L/PYCARD/IKBKG/SUGT1/MAPK8/IRAK4/CCL5/PRKCD/MAPK9/TLR4/TAB2/P2RX7/DHX33/TAB1/NLRP12/IL18/NEK7/NAIP/RHOA/MFN1/OAS2/TRPM7/OAS3/RNASEL/CYBB/TBK1/XIAP/STAT2/IFNAR1/VDAC1/TRPV2/TICAM1/CXCL8/CXCL1/CXCL3/ITPR2/ITPR1/IFNB1/CARD8/TRAF3/MAVS/PANX1/ERBIN/IFNAR2/TANK/MCU/CARD6/CASP5	80	http://www.kegg.jp/kegg-bin/show_pathway?hsa04621/MAPK14/MAPK3/IL1B/ANTXR1/BCL2/CTSB/CASP8/MAPK1/VDAC2/HSP90AB1/BCL2L1/ANTXR2/NAMPT/BIRC3/BIRC2/GABARAPL1/GABARAP/ATG12/MFN2/TNFAIP3/CCL2/YWHAE/HSP90AA1/TNF/MAPK10/TRAF6/JUN/STAT1/TXNIP/TXN/MAP3K7/NLRP3/DNM1L/PYCARD/IKBKG/SUGT1/MAPK8/IRAK4/CCL5/PRKCD/MAPK9/TLR4/TAB2/P2RX7/DHX33/TAB1/NLRP12/IL18/NEK7/NAIP/RHOA/MFN1/OAS2/TRPM7/OAS3/RNASEL/CYBB/TBK1/XIAP/STAT2/IFNAR1/VDAC1/TRPV2/TICAM1/CXCL8/CXCL1/CXCL3/ITPR2/ITPR1/IFNB1/CARD8/TRAF3/MAVS/PANX1/ERBIN/IFNAR2/TANK/MCU/CARD6/CASP5
hsa01210	2-Oxocarboxylic acid metabolism	10/3197	18/8019	0.131918747736559	0.256685274210292	0.149736562110615	IDH3A/IDH2/IDH3B/GOT1/ACO1/CS/BCAT2/ACY1/GPT2/ABHD14A-ACY1	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa01210/IDH3A/IDH2/IDH3B/GOT1/ACO1/CS/BCAT2/ACY1/GPT2/ABHD14A-ACY1
hsa01040	Biosynthesis of unsaturated fatty acids	14/3197	27/8019	0.141022370763025	0.271754055865545	0.158526889359402	ACOX1/ELOVL5/ELOVL7/HACD4/ELOVL6/TECR/HACD3/ELOVL1/ACOT2/SCP2/FADS1/SCD/HSD17B12/SCD5	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa01040/ACOX1/ELOVL5/ELOVL7/HACD4/ELOVL6/TECR/HACD3/ELOVL1/ACOT2/SCP2/FADS1/SCD/HSD17B12/SCD5
hsa04062	Chemokine signaling pathway	83/3197	189/8019	0.141345762803132	0.271754055865545	0.158526889359402	AKT3/MAPK3/PRKACB/KRAS/ARRB1/FOXO3/GRB2/MAPK1/SOS1/AKT1/CRKL/CCR6/MAP2K1/SRC/ARRB2/STAT3/HRAS/CCL2/STAT1/RAC1/CDC42/NRAS/ROCK1/GNAI3/IKBKG/BRAF/GNAI2/CCL16/ROCK2/CCR5/PAK1/CCL5/PRKCD/PIK3CG/CXCR4/SHC3/RAP1B/CRK/CCL22/PIK3CB/JAK2/PIK3R2/RAP1A/TIAM1/LYN/AKT2/PRKCB/ADCY9/RHOA/GRK2/PIK3CA/GRK3/ADCY2/GRK7/GSK3B/ADCY5/GRK4/PARD3/STAT2/PXN/GNB4/GNB2/CXCL10/SOS2/PIK3R1/CXCL12/GNG2/CXCL8/CCR2/VAV2/VAV3/BCAR1/GNG4/CXCL16/CCR4/CXCL5/CXCL1/CXCL14/CXCL3/GNG12/SHC4/GNB5/GNG5	83	http://www.kegg.jp/kegg-bin/show_pathway?hsa04062/AKT3/MAPK3/PRKACB/KRAS/ARRB1/FOXO3/GRB2/MAPK1/SOS1/AKT1/CRKL/CCR6/MAP2K1/SRC/ARRB2/STAT3/HRAS/CCL2/STAT1/RAC1/CDC42/NRAS/ROCK1/GNAI3/IKBKG/BRAF/GNAI2/CCL16/ROCK2/CCR5/PAK1/CCL5/PRKCD/PIK3CG/CXCR4/SHC3/RAP1B/CRK/CCL22/PIK3CB/JAK2/PIK3R2/RAP1A/TIAM1/LYN/AKT2/PRKCB/ADCY9/RHOA/GRK2/PIK3CA/GRK3/ADCY2/GRK7/GSK3B/ADCY5/GRK4/PARD3/STAT2/PXN/GNB4/GNB2/CXCL10/SOS2/PIK3R1/CXCL12/GNG2/CXCL8/CCR2/VAV2/VAV3/BCAR1/GNG4/CXCL16/CCR4/CXCL5/CXCL1/CXCL14/CXCL3/GNG12/SHC4/GNB5/GNG5
hsa03040	Spliceosome	66/3197	149/8019	0.151623562309967	0.289288413361728	0.168755502661722	SNRPA1/HSPA2/ALYREF/HNRNPU/DDX39B/CDC5L/HSPA1A/SNW1/TCERG1/HSPA1B/HSPA8/DHX15/EFTUD2/DDX42/HSPA6/AQR/DDX23/EIF4A3/RBM8A/MAGOH/HNRNPK/THOC2/HNRNPC/BCAS2/SNRPD3/SNRPD1/U2AF2/SRSF10/PRPF8/SF3A1/SF3A3/CRNKL1/ISY1/SRSF1/SF3B1/SRSF2/LSM3/PPIL1/RBM25/TRA2B/SRSF3/PHF5A/U2SURP/SF3B3/HNRNPA1/SRSF7/HNRNPA3/WBP11/SNRNP27/HNRNPM/LSM8/SF3B2/PRPF4/SMNDC1/SART1/SNRNP70/SNRPB2/PQBP1/PCBP1/CHERP/ZMAT2/PRPF40A/PRPF38A/RBMXL1/ACIN1/HNRNPA1L2	66	http://www.kegg.jp/kegg-bin/show_pathway?hsa03040/SNRPA1/HSPA2/ALYREF/HNRNPU/DDX39B/CDC5L/HSPA1A/SNW1/TCERG1/HSPA1B/HSPA8/DHX15/EFTUD2/DDX42/HSPA6/AQR/DDX23/EIF4A3/RBM8A/MAGOH/HNRNPK/THOC2/HNRNPC/BCAS2/SNRPD3/SNRPD1/U2AF2/SRSF10/PRPF8/SF3A1/SF3A3/CRNKL1/ISY1/SRSF1/SF3B1/SRSF2/LSM3/PPIL1/RBM25/TRA2B/SRSF3/PHF5A/U2SURP/SF3B3/HNRNPA1/SRSF7/HNRNPA3/WBP11/SNRNP27/HNRNPM/LSM8/SF3B2/PRPF4/SMNDC1/SART1/SNRNP70/SNRPB2/PQBP1/PCBP1/CHERP/ZMAT2/PRPF40A/PRPF38A/RBMXL1/ACIN1/HNRNPA1L2
hsa05014	Amyotrophic lateral sclerosis (ALS)	27/3197	57/8019	0.152753281212512	0.289288413361728	0.168755502661722	TP53/MAPK14/BCL2/BCL2L1/MAP2K6/BAX/SOD1/CASP3/RAB5A/BID/PPP3CA/TNF/RAC1/CYCS/DAXX/MAP3K5/MAP2K3/NOS1/APAF1/CCS/CASP9/SLC1A2/GRIN2A/TNFRSF1B/PPP3R1/TOMM40/TOMM40L	27	http://www.kegg.jp/kegg-bin/show_pathway?hsa05014/TP53/MAPK14/BCL2/BCL2L1/MAP2K6/BAX/SOD1/CASP3/RAB5A/BID/PPP3CA/TNF/RAC1/CYCS/DAXX/MAP3K5/MAP2K3/NOS1/APAF1/CCS/CASP9/SLC1A2/GRIN2A/TNFRSF1B/PPP3R1/TOMM40/TOMM40L
hsa04721	Synaptic vesicle cycle	36/3197	78/8019	0.153152689426797	0.289288413361728	0.168755502661722	SLC6A4/DNM2/UNC13B/STX2/ATP6V1B2/CLTC/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/SLC1A1/NSF/VAMP2/SYT1/CACNA1A/STX1B/STX3/UNC13A/CPLX1/DNM1/AP2A1/AP2B1/AP2M1/SLC1A2/SLC1A7/SLC6A5/SLC6A9/SLC6A1/SLC17A8/CLTB	36	http://www.kegg.jp/kegg-bin/show_pathway?hsa04721/SLC6A4/DNM2/UNC13B/STX2/ATP6V1B2/CLTC/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/SLC1A1/NSF/VAMP2/SYT1/CACNA1A/STX1B/STX3/UNC13A/CPLX1/DNM1/AP2A1/AP2B1/AP2M1/SLC1A2/SLC1A7/SLC6A5/SLC6A9/SLC6A1/SLC17A8/CLTB
hsa04713	Circadian entrainment	44/3197	97/8019	0.156887441630007	0.294620021200536	0.171865679631403	MAPK3/PRKACB/MAPK1/ADCYAP1R1/ADCYAP1/FOS/CAMK2A/CALM3/PER2/PER3/PER1/GNAI3/GNAI2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/PRKG2/CAMK2G/ADCY2/PRKG1/RPS6KA5/NOS1/GNAQ/ADCY5/RASD1/GUCY1A2/CREB1/GNB4/GNB2/CALM2/GNG2/GRIN2A/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR1/GNG12/GNB5/KCNJ6/GNG5/CALML4	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa04713/MAPK3/PRKACB/MAPK1/ADCYAP1R1/ADCYAP1/FOS/CAMK2A/CALM3/PER2/PER3/PER1/GNAI3/GNAI2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/PRKG2/CAMK2G/ADCY2/PRKG1/RPS6KA5/NOS1/GNAQ/ADCY5/RASD1/GUCY1A2/CREB1/GNB4/GNB2/CALM2/GNG2/GRIN2A/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR1/GNG12/GNB5/KCNJ6/GNG5/CALML4
hsa04923	Regulation of lipolysis in adipocytes	26/3197	55/8019	0.161672939436175	0.301851788658292	0.176084308847431	AKT3/PRKACB/PTGS2/AKT1/GNAI3/GNAI2/IRS2/PIK3CB/PIK3R2/IRS1/GNAS/AKT2/ADCY9/PIK3CA/PRKG2/ADCY2/NPR1/PRKG1/ADCY5/PIK3R1/PDE3B/PTGER3/IRS4/PNPLA2/PLIN1/ABHD5	26	http://www.kegg.jp/kegg-bin/show_pathway?hsa04923/AKT3/PRKACB/PTGS2/AKT1/GNAI3/GNAI2/IRS2/PIK3CB/PIK3R2/IRS1/GNAS/AKT2/ADCY9/PIK3CA/PRKG2/ADCY2/NPR1/PRKG1/ADCY5/PIK3R1/PDE3B/PTGER3/IRS4/PNPLA2/PLIN1/ABHD5
hsa00562	Inositol phosphate metabolism	34/3197	74/8019	0.169970491475641	0.315519935325471	0.184057580000845	PTEN/PLCD1/INPP5B/PLCD3/PIP4K2C/PIK3C3/PIKFYVE/MTMR3/ALDH6A1/CDIPT/FIG4/PLCE1/ITPKB/PIK3CG/PIK3CB/PIP5K1A/PIK3C2A/PIK3CA/PIK3C2B/IPPK/IPMK/PI4K2B/PI4K2A/PLCG1/INPPL1/OCRL/MTMR14/MTMR6/PLCG2/TPI1/INPP4B/INPP5A/SYNJ2/MIOX	34	http://www.kegg.jp/kegg-bin/show_pathway?hsa00562/PTEN/PLCD1/INPP5B/PLCD3/PIP4K2C/PIK3C3/PIKFYVE/MTMR3/ALDH6A1/CDIPT/FIG4/PLCE1/ITPKB/PIK3CG/PIK3CB/PIP5K1A/PIK3C2A/PIK3CA/PIK3C2B/IPPK/IPMK/PI4K2B/PI4K2A/PLCG1/INPPL1/OCRL/MTMR14/MTMR6/PLCG2/TPI1/INPP4B/INPP5A/SYNJ2/MIOX
hsa04961	Endocrine and other factor-regulated calcium reabsorption	25/3197	53/8019	0.171186576593886	0.315961509941859	0.184315171189808	PRKACB/VDR/ESR1/DNM2/ATP2B4/CLTC/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/DNM1/GNAQ/ATP2B1/AP2A1/SLC8A1/AP2B1/AP2M1/BDKRB2/SLC8A3/ATP1B3/FXYD2/KLK2/ATP1B4/CLTB	25	http://www.kegg.jp/kegg-bin/show_pathway?hsa04961/PRKACB/VDR/ESR1/DNM2/ATP2B4/CLTC/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/DNM1/GNAQ/ATP2B1/AP2A1/SLC8A1/AP2B1/AP2M1/BDKRB2/SLC8A3/ATP1B3/FXYD2/KLK2/ATP1B4/CLTB
hsa00531	Glycosaminoglycan degradation	10/3197	19/8019	0.182606960600477	0.33512527428383	0.19549429394429	SPAM1/GNS/IDS/GALNS/HEXA/SGSH/ARSB/HPSE/HGSNAT/GUSB	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00531/SPAM1/GNS/IDS/GALNS/HEXA/SGSH/ARSB/HPSE/HGSNAT/GUSB
hsa05414	Dilated cardiomyopathy (DCM)	43/3197	96/8019	0.187327277052721	0.34153959202311	0.19923606639119	TGFB2/PRKACB/ITGA5/ITGB1/IGF1/ITGB8/ITGA3/ITGA2/TGFB1/TTN/ACTB/TNF/ITGA1/DAG1/GNAS/ADCY9/ACTC1/ADCY2/ATP2A2/ACTG1/ADCY5/LMNA/EMD/TPM1/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/TNNI3/ITGB4/SLC8A3/TPM3/TNNC1/ITGA9/TPM2/CACNG6/CACNG1/CACNG8	43	http://www.kegg.jp/kegg-bin/show_pathway?hsa05414/TGFB2/PRKACB/ITGA5/ITGB1/IGF1/ITGB8/ITGA3/ITGA2/TGFB1/TTN/ACTB/TNF/ITGA1/DAG1/GNAS/ADCY9/ACTC1/ADCY2/ATP2A2/ACTG1/ADCY5/LMNA/EMD/TPM1/SLC8A1/LAMA2/ITGA7/ITGA8/ITGB3/CACNG7/ITGA11/CACNA1C/DMD/TNNI3/ITGB4/SLC8A3/TPM3/TNNC1/ITGA9/TPM2/CACNG6/CACNG1/CACNG8
hsa05152	Tuberculosis	78/3197	180/8019	0.188216864953912	0.34153959202311	0.19923606639119	AKT3/MAPK14/MAPK3/TGFB2/IL1B/VDR/BCL2/CASP8/MAPK1/AKT1/SRC/BAX/CYP27B1/CASP3/TGFB1/CEBPB/ATP6AP1/ATP6V0D1/ATP6V0A2/PIK3C3/RAB5A/EP300/BID/PPP3CA/CAMK2A/CALM3/TNF/MAPK10/CIITA/TRAF6/STAT1/CREBBP/HLA-DRB1/HLA-DRB5/CYCS/MAPK8/IRAK4/IRAK1/MAPK9/TLR4/TLR6/IRAK2/SYK/CALM1/JAK2/TIRAP/IL18/AKT2/RHOA/RAB5B/HSPA9/RAB5C/CAMK2G/HSPD1/APAF1/CREB1/HLA-DOB/LAMP1/C3/BCL10/CASP9/CORO1A/CALM2/NFYB/NFYC/NFYA/TLR2/ITGAX/CR1/MALT1/IFNB1/CLEC4E/PPP3R1/TRADD/IL10RB/EEA1/RFXAP/CALML4	78	http://www.kegg.jp/kegg-bin/show_pathway?hsa05152/AKT3/MAPK14/MAPK3/TGFB2/IL1B/VDR/BCL2/CASP8/MAPK1/AKT1/SRC/BAX/CYP27B1/CASP3/TGFB1/CEBPB/ATP6AP1/ATP6V0D1/ATP6V0A2/PIK3C3/RAB5A/EP300/BID/PPP3CA/CAMK2A/CALM3/TNF/MAPK10/CIITA/TRAF6/STAT1/CREBBP/HLA-DRB1/HLA-DRB5/CYCS/MAPK8/IRAK4/IRAK1/MAPK9/TLR4/TLR6/IRAK2/SYK/CALM1/JAK2/TIRAP/IL18/AKT2/RHOA/RAB5B/HSPA9/RAB5C/CAMK2G/HSPD1/APAF1/CREB1/HLA-DOB/LAMP1/C3/BCL10/CASP9/CORO1A/CALM2/NFYB/NFYC/NFYA/TLR2/ITGAX/CR1/MALT1/IFNB1/CLEC4E/PPP3R1/TRADD/IL10RB/EEA1/RFXAP/CALML4
hsa00565	Ether lipid metabolism	22/3197	47/8019	0.203805850830109	0.367761395631984	0.214532474558009	PLPP3/PAFAH1B2/PAFAH1B1/LPCAT2/LPCAT1/CHPT1/PLA2G5/AGPS/UGT8/ENPP2/ENPP6/PLA2G4A/PLA2G2F/PLA2G2D/GDPD1/CEPT1/PLD3/PLA2G2C/PLA2G12A/PAFAH2/SELENOI/PLA2G4D	22	http://www.kegg.jp/kegg-bin/show_pathway?hsa00565/PLPP3/PAFAH1B2/PAFAH1B1/LPCAT2/LPCAT1/CHPT1/PLA2G5/AGPS/UGT8/ENPP2/ENPP6/PLA2G4A/PLA2G2F/PLA2G2D/GDPD1/CEPT1/PLD3/PLA2G2C/PLA2G12A/PAFAH2/SELENOI/PLA2G4D
hsa05206	MicroRNAs in cancer	131/3197	310/8019	0.206492746872492	0.370539762443415	0.216153226258339	TP53/CDC25B/MAPK3/CCND1/TGFB2/BAK1/SIRT1/CDC25C/KRAS/VEGFA/EGFR/PTGS2/BCL2/GRB2/PDGFRA/E2F1/MTOR/MAPK1/SOS1/ST14/CCNE2/DNMT3A/CCNE1/PTEN/PDGFB/CDC25A/ITGA5/CRKL/BMPR2/HDAC4/MAP2K1/ATM/BCL2L11/PDGFRB/RECK/BCL2L2/NOTCH1/CDKN1B/HOXD10/TNC/ZFPM2/MMP9/CASP3/STAT3/HDAC2/KIF23/SLC7A1/APC/HRAS/EP300/MDM2/MDM4/HMGA2/CDKN1A/SOX4/CCNG1/CDKN2A/CCND2/MYC/RDX/EZH2/TRIM71/CDK6/HDAC1/HDAC5/NOTCH3/UBE2I/EFNA1/DNMT1/E2F2/DNMT3B/ZEB1/EZR/CREBBP/BMI1/E2F3/DICER1/ZEB2/NOTCH2/NRAS/ROCK1/PDGFA/ABL1/ERBB2/PAK4/ERBB3/THBS1/MAPK7/IRS2/CRK/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/FGFR3/CD44/TIMP3/IRS1/PDCD4/PRKCB/RHOA/PIK3CA/ABCC1/RPS6KA5/PIM1/EFNA5/APC2/STMN1/HNRNPK/TPM1/CYP1B1/SOS2/PLCG1/PIK3R1/EFNA3/TNR/ITGB3/FOXP1/SOCS1/MMP16/VIM/DDIT4/BMF/MARCKS/MCL1/FSCN1/PLCG2/IGF2BP1/SHC4/COMMD3-BMI1	131	http://www.kegg.jp/kegg-bin/show_pathway?hsa05206/TP53/CDC25B/MAPK3/CCND1/TGFB2/BAK1/SIRT1/CDC25C/KRAS/VEGFA/EGFR/PTGS2/BCL2/GRB2/PDGFRA/E2F1/MTOR/MAPK1/SOS1/ST14/CCNE2/DNMT3A/CCNE1/PTEN/PDGFB/CDC25A/ITGA5/CRKL/BMPR2/HDAC4/MAP2K1/ATM/BCL2L11/PDGFRB/RECK/BCL2L2/NOTCH1/CDKN1B/HOXD10/TNC/ZFPM2/MMP9/CASP3/STAT3/HDAC2/KIF23/SLC7A1/APC/HRAS/EP300/MDM2/MDM4/HMGA2/CDKN1A/SOX4/CCNG1/CDKN2A/CCND2/MYC/RDX/EZH2/TRIM71/CDK6/HDAC1/HDAC5/NOTCH3/UBE2I/EFNA1/DNMT1/E2F2/DNMT3B/ZEB1/EZR/CREBBP/BMI1/E2F3/DICER1/ZEB2/NOTCH2/NRAS/ROCK1/PDGFA/ABL1/ERBB2/PAK4/ERBB3/THBS1/MAPK7/IRS2/CRK/MET/PIK3CB/PRKCA/PIK3R2/MAP2K2/FGFR3/CD44/TIMP3/IRS1/PDCD4/PRKCB/RHOA/PIK3CA/ABCC1/RPS6KA5/PIM1/EFNA5/APC2/STMN1/HNRNPK/TPM1/CYP1B1/SOS2/PLCG1/PIK3R1/EFNA3/TNR/ITGB3/FOXP1/SOCS1/MMP16/VIM/DDIT4/BMF/MARCKS/MCL1/FSCN1/PLCG2/IGF2BP1/SHC4/COMMD3-BMI1
hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	8/3197	15/8019	0.209786717155575	0.374370771498623	0.218388033561198	A4GALT/B3GALNT1/B3GALT5/ST3GAL2/FUT9/ST3GAL1/HEXA/GLA	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00603/A4GALT/B3GALNT1/B3GALT5/ST3GAL2/FUT9/ST3GAL1/HEXA/GLA
hsa01523	Antifolate resistance	15/3197	31/8019	0.214501475058638	0.380681189252418	0.22206919627239	IL1B/TYMS/MTHFR/TNF/FOLR1/IKBKG/GART/ABCC5/ABCC1/ABCG2/FPGS/SHMT1/SHMT2/SLC46A1/ATIC	15	http://www.kegg.jp/kegg-bin/show_pathway?hsa01523/IL1B/TYMS/MTHFR/TNF/FOLR1/IKBKG/GART/ABCC5/ABCC1/ABCG2/FPGS/SHMT1/SHMT2/SLC46A1/ATIC
hsa03050	Proteasome	21/3197	45/8019	0.216239557353612	0.381668726913753	0.222645273317783	PSME4/PSMD13/PSME3/PSMB2/PSMB5/PSMA7/PSMF1/PSMD4/PSMB9/PSMD1/PSMC4/PSMA5/PSMD2/PSMB7/PSMA2/PSMD8/PSMD11/PSMD3/ADRM1/SEM1/POMP	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa03050/PSME4/PSMD13/PSME3/PSMB2/PSMB5/PSMA7/PSMF1/PSMD4/PSMB9/PSMD1/PSMC4/PSMA5/PSMD2/PSMB7/PSMA2/PSMD8/PSMD11/PSMD3/ADRM1/SEM1/POMP
hsa00240	Pyrimidine metabolism	26/3197	57/8019	0.224533794975766	0.392300857978364	0.228847494144133	UMPS/CAD/DHODH/TYMS/RRM2/ENTPD6/ENTPD4/NT5C3A/NME6/TK1/NME2/CTPS1/DCK/UCK2/NT5C1B/NT5C2/UCK1/DTYMK/ENPP1/ENTPD1/DCTPP1/CMPK1/DUT/PNP/ENTPD5/NT5C1B-RDH14	26	http://www.kegg.jp/kegg-bin/show_pathway?hsa00240/UMPS/CAD/DHODH/TYMS/RRM2/ENTPD6/ENTPD4/NT5C3A/NME6/TK1/NME2/CTPS1/DCK/UCK2/NT5C1B/NT5C2/UCK1/DTYMK/ENPP1/ENTPD1/DCTPP1/CMPK1/DUT/PNP/ENTPD5/NT5C1B-RDH14
hsa03320	PPAR signaling pathway	34/3197	76/8019	0.224692441876153	0.392300857978364	0.228847494144133	PPARG/ACOX1/ACSL4/RXRA/HMGCS1/PPARD/SLC27A2/ACSBG1/SLC27A4/ACADL/SCP2/CD36/PPARA/NR1H3/UBC/ADIPOQ/ILK/PDPK1/SLC27A1/ACSL6/ACSL3/ACSL1/PCK1/CPT1A/LPL/SCD/OLR1/MMP1/FABP2/CPT1C/CYP8B1/CPT1B/SCD5/PLIN1	34	http://www.kegg.jp/kegg-bin/show_pathway?hsa03320/PPARG/ACOX1/ACSL4/RXRA/HMGCS1/PPARD/SLC27A2/ACSBG1/SLC27A4/ACADL/SCP2/CD36/PPARA/NR1H3/UBC/ADIPOQ/ILK/PDPK1/SLC27A1/ACSL6/ACSL3/ACSL1/PCK1/CPT1A/LPL/SCD/OLR1/MMP1/FABP2/CPT1C/CYP8B1/CPT1B/SCD5/PLIN1
hsa04512	ECM-receptor interaction	39/3197	88/8019	0.22637739101718	0.393117727411554	0.229324012405632	SDC1/ITGA5/ITGB1/ITGB8/TNC/ITGA3/ITGA2/CD36/ITGA1/THBS1/FN1/DAG1/CD44/COL1A1/SDC4/COL6A1/LAMA2/ITGA7/TNR/LAMC1/COL4A4/ITGA8/ITGB3/COL1A2/COL4A1/FREM1/COL9A2/ITGA11/SV2A/CD47/THBS2/COL4A2/FREM2/ITGB4/LAMA4/SV2B/GP5/ITGA9/COL4A5	39	http://www.kegg.jp/kegg-bin/show_pathway?hsa04512/SDC1/ITGA5/ITGB1/ITGB8/TNC/ITGA3/ITGA2/CD36/ITGA1/THBS1/FN1/DAG1/CD44/COL1A1/SDC4/COL6A1/LAMA2/ITGA7/TNR/LAMC1/COL4A4/ITGA8/ITGB3/COL1A2/COL4A1/FREM1/COL9A2/ITGA11/SV2A/CD47/THBS2/COL4A2/FREM2/ITGB4/LAMA4/SV2B/GP5/ITGA9/COL4A5
hsa00250	Alanine, aspartate and glutamate metabolism	17/3197	36/8019	0.230473305747606	0.398090255382228	0.232224721243014	ABAT/CAD/CPS1/ASS1/GLUD2/GLUL/RIMKLA/GLUD1/ASNS/GOT1/ALDH5A1/ADSL/GFPT2/ASPA/GPT2/NAT8L/GFPT1	17	http://www.kegg.jp/kegg-bin/show_pathway?hsa00250/ABAT/CAD/CPS1/ASS1/GLUD2/GLUL/RIMKLA/GLUD1/ASNS/GOT1/ALDH5A1/ADSL/GFPT2/ASPA/GPT2/NAT8L/GFPT1
hsa04925	Aldosterone synthesis and secretion	43/3197	98/8019	0.237295674358899	0.40769416392513	0.237827131636299	PRKACB/MC2R/ATP2B4/STAR/ATF2/CAMK2A/CALM3/NR4A2/CREB3/CALM1/PRKD2/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/NPR1/GNAQ/ADCY5/ATP2B1/CAMK4/GNA11/CAMK1D/CREB1/HSD3B1/SCARB1/LDLR/CREB3L2/CALM2/ATF6B/ATF4/CREB5/CACNA1C/KCNJ5/ITPR2/ITPR1/KCNK3/ATP1B3/CYP11A1/ATP1B4/CALML4	43	http://www.kegg.jp/kegg-bin/show_pathway?hsa04925/PRKACB/MC2R/ATP2B4/STAR/ATF2/CAMK2A/CALM3/NR4A2/CREB3/CALM1/PRKD2/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/NPR1/GNAQ/ADCY5/ATP2B1/CAMK4/GNA11/CAMK1D/CREB1/HSD3B1/SCARB1/LDLR/CREB3L2/CALM2/ATF6B/ATF4/CREB5/CACNA1C/KCNJ5/ITPR2/ITPR1/KCNK3/ATP1B3/CYP11A1/ATP1B4/CALML4
hsa00100	Steroid biosynthesis	10/3197	20/8019	0.240548023122561	0.408931639308354	0.238549009079991	DHCR24/CYP27B1/SOAT1/LBR/EBP/SC5D/MSMO1/LIPA/CYP51A1/FDFT1	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00100/DHCR24/CYP27B1/SOAT1/LBR/EBP/SC5D/MSMO1/LIPA/CYP51A1/FDFT1
hsa00670	One carbon pool by folate	10/3197	20/8019	0.240548023122561	0.408931639308354	0.238549009079991	TYMS/MTHFR/MTHFD1/FTCD/GART/MTHFD1L/MTHFD2/SHMT1/SHMT2/ATIC	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00670/TYMS/MTHFR/MTHFD1/FTCD/GART/MTHFD1L/MTHFD2/SHMT1/SHMT2/ATIC
hsa05032	Morphine addiction	40/3197	91/8019	0.242961940470797	0.410491645080062	0.239459033629888	PRKACB/ARRB1/GABRB1/ARRB2/GNAI3/CACNA1A/GNAI2/PDE8A/PRKCA/GNAS/PRKCB/ADCY9/PDE10A/GRK2/GRK3/ADCY2/PDE11A/ADCY5/GRK4/PDE4A/GNB4/GNB2/GNG2/GABRA2/KCNJ3/KCNJ5/PDE3B/GNG4/GABRA5/GNG12/GABRA4/GABRQ/GABRB2/PDE1A/GNB5/KCNJ6/GABBR2/PDE4C/GNG5/PDE7A	40	http://www.kegg.jp/kegg-bin/show_pathway?hsa05032/PRKACB/ARRB1/GABRB1/ARRB2/GNAI3/CACNA1A/GNAI2/PDE8A/PRKCA/GNAS/PRKCB/ADCY9/PDE10A/GRK2/GRK3/ADCY2/PDE11A/ADCY5/GRK4/PDE4A/GNB4/GNB2/GNG2/GABRA2/KCNJ3/KCNJ5/PDE3B/GNG4/GABRA5/GNG12/GABRA4/GABRQ/GABRB2/PDE1A/GNB5/KCNJ6/GABBR2/PDE4C/GNG5/PDE7A
hsa00062	Fatty acid elongation	13/3197	27/8019	0.245278289475083	0.410491645080062	0.239459033629888	ELOVL5/ELOVL7/HACD4/ELOVL6/TECR/HACD3/ELOVL1/ACOT2/HADHA/ACAA2/THEM4/HSD17B12/HADHB	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00062/ELOVL5/ELOVL7/HACD4/ELOVL6/TECR/HACD3/ELOVL1/ACOT2/HADHA/ACAA2/THEM4/HSD17B12/HADHB
hsa04966	Collecting duct acid secretion	13/3197	27/8019	0.245278289475083	0.410491645080062	0.239459033629888	ATP6V1B2/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/SLC4A1/SLC12A7	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa04966/ATP6V1B2/ATP6V1F/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/SLC4A1/SLC12A7
hsa00230	Purine metabolism	56/3197	130/8019	0.252634743755741	0.420623825943837	0.24536961005034	RRM2/PAPSS1/ENTPD6/ENTPD4/PDE8A/NT5C3A/GART/PRPS1L1/NME6/ADCY9/PDE10A/AK3/ITPA/AK2/PAICS/NME2/AK4/FHIT/IMPDH1/GMPS/DCK/ADCY2/NPR1/NT5C1B/NT5C2/PRPS1/PFAS/PDE11A/HPRT1/PKM/ADCY5/ENPP1/ENTPD1/IMPDH2/ADK/GUCY1A2/NUDT16/PDE4A/PGM2/ADA2/PDE3B/PDE6B/PDE6A/ADSL/PNP/AMPD3/ENPP4/PDE6D/ATIC/NUDT9/ENTPD5/PDE1A/PDE4C/PDE7A/GMPR/NT5C1B-RDH14	56	http://www.kegg.jp/kegg-bin/show_pathway?hsa00230/RRM2/PAPSS1/ENTPD6/ENTPD4/PDE8A/NT5C3A/GART/PRPS1L1/NME6/ADCY9/PDE10A/AK3/ITPA/AK2/PAICS/NME2/AK4/FHIT/IMPDH1/GMPS/DCK/ADCY2/NPR1/NT5C1B/NT5C2/PRPS1/PFAS/PDE11A/HPRT1/PKM/ADCY5/ENPP1/ENTPD1/IMPDH2/ADK/GUCY1A2/NUDT16/PDE4A/PGM2/ADA2/PDE3B/PDE6B/PDE6A/ADSL/PNP/AMPD3/ENPP4/PDE6D/ATIC/NUDT9/ENTPD5/PDE1A/PDE4C/PDE7A/GMPR/NT5C1B-RDH14
hsa00010	Glycolysis / Gluconeogenesis	30/3197	68/8019	0.274468547310585	0.454632516827277	0.265208474864209	ALDOA/ENO4/ENO1/HK1/PFKP/LDHA/ALDH1B1/PGK1/ADH4/PFKM/LDHB/GAPDH/GCK/PCK1/PKM/HK2/ALDH2/PGM2/G6PC/ALDH9A1/ADH5/ALDH3A1/ALDOC/PGAM1/TPI1/PDHA1/PDHB/DLAT/PGAM4/GALM	30	http://www.kegg.jp/kegg-bin/show_pathway?hsa00010/ALDOA/ENO4/ENO1/HK1/PFKP/LDHA/ALDH1B1/PGK1/ADH4/PFKM/LDHB/GAPDH/GCK/PCK1/PKM/HK2/ALDH2/PGM2/G6PC/ALDH9A1/ADH5/ALDH3A1/ALDOC/PGAM1/TPI1/PDHA1/PDHB/DLAT/PGAM4/GALM
hsa04650	Natural killer cell mediated cytotoxicity	56/3197	131/8019	0.27675101931153	0.456074383865429	0.266049583548678	MAPK3/TNFSF10/KRAS/GRB2/MAPK1/SOS1/ICAM1/MAP2K1/CASP3/PTPN11/HRAS/PTPN6/BID/PPP3CA/TNF/NFATC2/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/NRAS/BRAF/PAK1/FAS/SHC3/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/PRKCB/PIK3CA/NFATC1/IFNAR1/SOS2/PLCG1/PIK3R1/MICB/VAV2/VAV3/PLCG2/IFNB1/MICA/RAET1E/ULBP2/ULBP3/PPP3R1/SH2D1A/TNFRSF10B/TNFRSF10A/IFNAR2/KLRD1/SHC4/KLRC3	56	http://www.kegg.jp/kegg-bin/show_pathway?hsa04650/MAPK3/TNFSF10/KRAS/GRB2/MAPK1/SOS1/ICAM1/MAP2K1/CASP3/PTPN11/HRAS/PTPN6/BID/PPP3CA/TNF/NFATC2/HLA-A/RAC1/HLA-B/HLA-C/HLA-E/NRAS/BRAF/PAK1/FAS/SHC3/FYN/SYK/PIK3CB/PRKCA/PIK3R2/MAP2K2/PRKCB/PIK3CA/NFATC1/IFNAR1/SOS2/PLCG1/PIK3R1/MICB/VAV2/VAV3/PLCG2/IFNB1/MICA/RAET1E/ULBP2/ULBP3/PPP3R1/SH2D1A/TNFRSF10B/TNFRSF10A/IFNAR2/KLRD1/SHC4/KLRC3
hsa04750	Inflammatory mediator regulation of TRP channels	43/3197	100/8019	0.292714995935288	0.479933724299989	0.279967856117641	MAPK14/IL1B/PRKACB/MAP2K6/SRC/IGF1/CAMK2A/CALM3/PPP1CB/MAPK10/TRPV1/PPP1CC/MAPK8/PRKCD/MAPK9/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K3/F2RL1/GNAS/PRKCB/ADCY9/PIK3CA/PRKCH/CAMK2G/ADCY2/GNAQ/ADCY5/PLCG1/PIK3R1/TRPV2/CALM2/BDKRB2/ASIC4/ITPR2/ITPR1/PLA2G4A/PLCG2/IL1RAP/PLA2G4D/CALML4	43	http://www.kegg.jp/kegg-bin/show_pathway?hsa04750/MAPK14/IL1B/PRKACB/MAP2K6/SRC/IGF1/CAMK2A/CALM3/PPP1CB/MAPK10/TRPV1/PPP1CC/MAPK8/PRKCD/MAPK9/CALM1/PIK3CB/PRKCA/PIK3R2/MAP2K3/F2RL1/GNAS/PRKCB/ADCY9/PIK3CA/PRKCH/CAMK2G/ADCY2/GNAQ/ADCY5/PLCG1/PIK3R1/TRPV2/CALM2/BDKRB2/ASIC4/ITPR2/ITPR1/PLA2G4A/PLCG2/IL1RAP/PLA2G4D/CALML4
hsa00600	Sphingolipid metabolism	21/3197	47/8019	0.296981915784435	0.48447049898168	0.282614369619425	PLPP3/SGPL1/CERS1/UGCG/ACER3/SGMS2/ACER2/GBA2/CERK/GLA/ARSA/GALC/UGT8/DEGS1/SPTLC2/SPTLC3/SPTLC1/CERS2/SGPP2/KDSR/CERS4	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa00600/PLPP3/SGPL1/CERS1/UGCG/ACER3/SGMS2/ACER2/GBA2/CERK/GLA/ARSA/GALC/UGT8/DEGS1/SPTLC2/SPTLC3/SPTLC1/CERS2/SGPP2/KDSR/CERS4
hsa05323	Rheumatoid arthritis	40/3197	93/8019	0.301188314810151	0.487353959680297	0.284296427514333	TGFB2/IL1B/VEGFA/CSF1/ICAM1/TGFB1/FOS/CD28/TNFSF13/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/CCL2/TNF/JUN/HLA-DRB1/HLA-DRB5/CCL5/TLR4/FLT1/IL11/IL18/HLA-DOB/CXCL12/TLR2/CXCL8/CXCL5/CXCL1/CXCL3/TNFSF13B/MMP1	40	http://www.kegg.jp/kegg-bin/show_pathway?hsa05323/TGFB2/IL1B/VEGFA/CSF1/ICAM1/TGFB1/FOS/CD28/TNFSF13/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/CCL2/TNF/JUN/HLA-DRB1/HLA-DRB5/CCL5/TLR4/FLT1/IL11/IL18/HLA-DOB/CXCL12/TLR2/CXCL8/CXCL5/CXCL1/CXCL3/TNFSF13B/MMP1
hsa04270	Vascular smooth muscle contraction	56/3197	132/8019	0.301767157696778	0.487353959680297	0.284296427514333	MAPK3/PRKACB/MAPK1/EDN1/AVPR1A/MAP2K1/NPPC/ADM/CALM3/PPP1R12B/PPP1R12A/PPP1CB/ROCK1/PPP1CC/BRAF/ROCK2/PRKCD/EDN3/PLA2G5/CALM1/PRKCA/MAP2K2/ADORA2B/GNA12/GNAS/MYH11/PRKCB/ADCY9/RHOA/PRKCH/ADCY2/NPR1/PRKG1/GNA13/MYLK3/GNAQ/ADCY5/GNA11/MYLK4/GUCY1A2/CALM2/KCNMB1/KCNMB4/CACNA1C/NPPB/EDNRA/ITPR2/ITPR1/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PPP1R12C/PLA2G4D/CALML4	56	http://www.kegg.jp/kegg-bin/show_pathway?hsa04270/MAPK3/PRKACB/MAPK1/EDN1/AVPR1A/MAP2K1/NPPC/ADM/CALM3/PPP1R12B/PPP1R12A/PPP1CB/ROCK1/PPP1CC/BRAF/ROCK2/PRKCD/EDN3/PLA2G5/CALM1/PRKCA/MAP2K2/ADORA2B/GNA12/GNAS/MYH11/PRKCB/ADCY9/RHOA/PRKCH/ADCY2/NPR1/PRKG1/GNA13/MYLK3/GNAQ/ADCY5/GNA11/MYLK4/GUCY1A2/CALM2/KCNMB1/KCNMB4/CACNA1C/NPPB/EDNRA/ITPR2/ITPR1/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PPP1R12C/PLA2G4D/CALML4
hsa00220	Arginine biosynthesis	10/3197	21/8019	0.30392239784128	0.488392708968824	0.284902378704316	CPS1/ASS1/GLUD2/GLUL/GLUD1/NOS1/GOT1/ACY1/GPT2/ABHD14A-ACY1	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00220/CPS1/ASS1/GLUD2/GLUL/GLUD1/NOS1/GOT1/ACY1/GPT2/ABHD14A-ACY1
hsa04911	Insulin secretion	37/3197	86/8019	0.31016089722013	0.49595034555496	0.289311102670158	PRKACB/SLC2A1/ADCYAP1R1/ADCYAP1/ATF2/CAMK2A/CREB3/VAMP2/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/GCK/GNAQ/ADCY5/KCNJ11/GNA11/CREB1/CREB3L2/ATF6B/ATF4/CREB5/KCNMB1/FFAR1/KCNMB4/CACNA1C/GLP1R/ATP1B3/FXYD2/KCNN4/CHRM3/KCNN1/ATP1B4/KCNN3	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa04911/PRKACB/SLC2A1/ADCYAP1R1/ADCYAP1/ATF2/CAMK2A/CREB3/VAMP2/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/CAMK2G/ADCY2/GCK/GNAQ/ADCY5/KCNJ11/GNA11/CREB1/CREB3L2/ATF6B/ATF4/CREB5/KCNMB1/FFAR1/KCNMB4/CACNA1C/GLP1R/ATP1B3/FXYD2/KCNN4/CHRM3/KCNN1/ATP1B4/KCNN3
hsa03022	Basal transcription factors	20/3197	45/8019	0.31440358756494	0.500257925041751	0.291823915862713	TBP/TBPL1/CDK7/GTF2H1/TAF2/TAF7/TAF3/TAF6/TAF12/TBPL2/GTF2H5/GTF2F1/GTF2H2C/GTF2A1/TAF8/GTF2H3/TAF13/GTF2E1/TAF11/TAF15	20	http://www.kegg.jp/kegg-bin/show_pathway?hsa03022/TBP/TBPL1/CDK7/GTF2H1/TAF2/TAF7/TAF3/TAF6/TAF12/TBPL2/GTF2H5/GTF2F1/GTF2H2C/GTF2A1/TAF8/GTF2H3/TAF13/GTF2E1/TAF11/TAF15
hsa00510	N-Glycan biosynthesis	22/3197	50/8019	0.32243829940591	0.51052730739269	0.297814528347047	B4GALT1/ALG9/ALG3/DPM3/ALG1/MAN1A2/MGAT1/MGAT4B/ST6GAL2/FUT8/B4GALT2/MGAT5/MAN1C1/RPN2/DAD1/GANAB/RPN1/DOLK/MOGS/ALG10B/SRD5A3/ALG14	22	http://www.kegg.jp/kegg-bin/show_pathway?hsa00510/B4GALT1/ALG9/ALG3/DPM3/ALG1/MAN1A2/MGAT1/MGAT4B/ST6GAL2/FUT8/B4GALT2/MGAT5/MAN1C1/RPN2/DAD1/GANAB/RPN1/DOLK/MOGS/ALG10B/SRD5A3/ALG14
hsa04727	GABAergic synapse	38/3197	89/8019	0.32825192390491	0.51719693376237	0.301705234295141	ABAT/PRKACB/SLC38A2/GABRB1/SRC/GABARAPL1/GABARAP/NSF/GNAI3/CACNA1A/GNAI2/PRKCA/PRKCB/ADCY9/GLUL/ADCY2/ADCY5/GPHN/GNB4/GNB2/GNG2/SLC38A1/SLC6A1/GABRA2/CACNA1C/GNG4/PLCL1/GABRA5/GNG12/GABRA4/GABRQ/GABRB2/SLC12A5/SLC38A5/GNB5/KCNJ6/GABBR2/GNG5	38	http://www.kegg.jp/kegg-bin/show_pathway?hsa04727/ABAT/PRKACB/SLC38A2/GABRB1/SRC/GABARAPL1/GABARAP/NSF/GNAI3/CACNA1A/GNAI2/PRKCA/PRKCB/ADCY9/GLUL/ADCY2/ADCY5/GPHN/GNB4/GNB2/GNG2/SLC38A1/SLC6A1/GABRA2/CACNA1C/GNG4/PLCL1/GABRA5/GNG12/GABRA4/GABRQ/GABRB2/SLC12A5/SLC38A5/GNB5/KCNJ6/GABBR2/GNG5
hsa00512	Mucin type O-glycan biosynthesis	14/3197	31/8019	0.334079423747214	0.523823562477428	0.305570857694182	ST3GAL2/GCNT3/C1GALT1/GALNT6/GALNT4/GALNT1/GALNT3/ST3GAL1/GALNT2/B4GALT5/C1GALT1C1/GALNT7/GALNT10/POC1B-GALNT4	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa00512/ST3GAL2/GCNT3/C1GALT1/GALNT6/GALNT4/GALNT1/GALNT3/ST3GAL1/GALNT2/B4GALT5/C1GALT1C1/GALNT7/GALNT10/POC1B-GALNT4
hsa03440	Homologous recombination	18/3197	41/8019	0.3528061271014	0.550513908472233	0.321140588615056	TOP3A/MRE11/RBBP8/BRIP1/RAD51C/ATM/RAD51D/XRCC2/RPA1/RAD51/XRCC3/RPA3/POLD4/POLD2/POLD3/RAD52/PALB2/SEM1	18	http://www.kegg.jp/kegg-bin/show_pathway?hsa03440/TOP3A/MRE11/RBBP8/BRIP1/RAD51C/ATM/RAD51D/XRCC2/RPA1/RAD51/XRCC3/RPA3/POLD4/POLD2/POLD3/RAD52/PALB2/SEM1
hsa00514	Other types of O-glycan biosynthesis	20/3197	46/8019	0.359829380326389	0.558773508872229	0.325958801004168	B4GALT1/OGT/C1GALT1/GALNT6/ST6GAL2/GALNT4/GALNT1/GALNT3/B4GALT2/GALNT2/C1GALT1C1/GALNT7/GALNT10/POFUT1/POFUT2/COLGALT1/EOGT/GXYLT2/GXYLT1/POC1B-GALNT4	20	http://www.kegg.jp/kegg-bin/show_pathway?hsa00514/B4GALT1/OGT/C1GALT1/GALNT6/ST6GAL2/GALNT4/GALNT1/GALNT3/B4GALT2/GALNT2/C1GALT1C1/GALNT7/GALNT10/POFUT1/POFUT2/COLGALT1/EOGT/GXYLT2/GXYLT1/POC1B-GALNT4
hsa00072	Synthesis and degradation of ketone bodies	5/3197	10/8019	0.363520566793031	0.561804512316502	0.327726927504167	HMGCS1/BDH2/OXCT1/BDH1/HMGCLL1	5	http://www.kegg.jp/kegg-bin/show_pathway?hsa00072/HMGCS1/BDH2/OXCT1/BDH1/HMGCLL1
hsa04146	Peroxisome	35/3197	83/8019	0.37292279247016	0.573495436907844	0.334546792264964	ACOX1/ACSL4/SOD1/ABCD1/SLC27A2/ABCD2/PEX2/SCP2/PRDX1/ACSL6/ACSL3/PEX1/ACSL1/AGPS/IDH2/PEX14/PEX7/PEX19/PEX5L/HACL1/NUDT7/SLC25A17/SOD2/PEX13/FAR2/HMGCLL1/PEX26/PEX11B/MPV17L/GSTK1/PEX10/PAOX/CROT/NUDT19/PXMP4	35	http://www.kegg.jp/kegg-bin/show_pathway?hsa04146/ACOX1/ACSL4/SOD1/ABCD1/SLC27A2/ABCD2/PEX2/SCP2/PRDX1/ACSL6/ACSL3/PEX1/ACSL1/AGPS/IDH2/PEX14/PEX7/PEX19/PEX5L/HACL1/NUDT7/SLC25A17/SOD2/PEX13/FAR2/HMGCLL1/PEX26/PEX11B/MPV17L/GSTK1/PEX10/PAOX/CROT/NUDT19/PXMP4
hsa00561	Glycerolipid metabolism	26/3197	61/8019	0.375443079248291	0.573495436907844	0.334546792264964	PLPP3/PNPLA3/AGPAT3/DGKG/DGKE/ALDH1B1/DGKD/DGKH/ALDH2/GLA/AKR1B10/LPL/ALDH9A1/DGAT1/PLPP4/GPAT4/AGPAT5/LCLAT1/MBOAT2/LIPC/AGPAT4/PNPLA2/LPIN3/LIPG/MOGAT3/MOGAT1	26	http://www.kegg.jp/kegg-bin/show_pathway?hsa00561/PLPP3/PNPLA3/AGPAT3/DGKG/DGKE/ALDH1B1/DGKD/DGKH/ALDH2/GLA/AKR1B10/LPL/ALDH9A1/DGAT1/PLPP4/GPAT4/AGPAT5/LCLAT1/MBOAT2/LIPC/AGPAT4/PNPLA2/LPIN3/LIPG/MOGAT3/MOGAT1
hsa04630	JAK-STAT signaling pathway	67/3197	162/8019	0.376411865710412	0.573495436907844	0.334546792264964	AKT3/CCND1/EGFR/BCL2/GRB2/PDGFRA/MTOR/SOS1/AKT1/SOCS3/PDGFB/BCL2L1/LIF/LEP/PDGFRB/PRLR/PTPN11/STAT3/IL7R/HRAS/EP300/CDKN1A/CCND3/CCND2/PTPN6/MYC/PTPN2/STAT1/PIAS4/CREBBP/PDGFA/IL2RB/IL2RA/PIK3CB/JAK2/IL11/PIK3R2/AKT2/PIK3CA/PIM1/STAT2/IFNAR1/SOS2/PIK3R1/MPL/STAT5A/PIAS2/SOCS1/IL6R/IL6ST/IL21R/CNTF/MCL1/SOCS6/IFNB1/IL23R/IL20RB/SOCS5/SOCS4/IFNAR2/LIFR/IFNLR1/IL10RB/OSMR/SOCS7/STAM/IL13RA1	67	http://www.kegg.jp/kegg-bin/show_pathway?hsa04630/AKT3/CCND1/EGFR/BCL2/GRB2/PDGFRA/MTOR/SOS1/AKT1/SOCS3/PDGFB/BCL2L1/LIF/LEP/PDGFRB/PRLR/PTPN11/STAT3/IL7R/HRAS/EP300/CDKN1A/CCND3/CCND2/PTPN6/MYC/PTPN2/STAT1/PIAS4/CREBBP/PDGFA/IL2RB/IL2RA/PIK3CB/JAK2/IL11/PIK3R2/AKT2/PIK3CA/PIM1/STAT2/IFNAR1/SOS2/PIK3R1/MPL/STAT5A/PIAS2/SOCS1/IL6R/IL6ST/IL21R/CNTF/MCL1/SOCS6/IFNB1/IL23R/IL20RB/SOCS5/SOCS4/IFNAR2/LIFR/IFNLR1/IL10RB/OSMR/SOCS7/STAM/IL13RA1
hsa00071	Fatty acid degradation	19/3197	44/8019	0.380258122621752	0.576635556839558	0.336378571530979	ACOX1/ACSL4/ACSBG1/HADHA/ACADL/ACADVL/ACSL6/ACSL3/ALDH1B1/ACSL1/ADH4/ALDH2/CPT1A/ALDH9A1/ADH5/ACAA2/CPT1C/HADHB/CPT1B	19	http://www.kegg.jp/kegg-bin/show_pathway?hsa00071/ACOX1/ACSL4/ACSBG1/HADHA/ACADL/ACADVL/ACSL6/ACSL3/ALDH1B1/ACSL1/ADH4/ALDH2/CPT1A/ALDH9A1/ADH5/ACAA2/CPT1C/HADHB/CPT1B
hsa05030	Cocaine addiction	21/3197	49/8019	0.385540903541159	0.581914541326143	0.339458050830632	PRKACB/FOSB/ATF2/CDK5R1/JUN/CREB3/GPSM1/GNAI3/GNAI2/DLG4/GNAS/ADCY5/CREB1/CREB3L2/BDNF/ATF6B/ATF4/CREB5/DDC/MAOA/GRIN2A	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa05030/PRKACB/FOSB/ATF2/CDK5R1/JUN/CREB3/GPSM1/GNAI3/GNAI2/DLG4/GNAS/ADCY5/CREB1/CREB3L2/BDNF/ATF6B/ATF4/CREB5/DDC/MAOA/GRIN2A
hsa00030	Pentose phosphate pathway	13/3197	30/8019	0.415575701590873	0.624330007506288	0.364200982055159	ALDOA/PRPS1L1/PFKP/PFKM/PGD/G6PD/PRPS1/IDNK/PGM2/ALDOC/DERA/TKT/PGLS	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00030/ALDOA/PRPS1L1/PFKP/PFKM/PGD/G6PD/PRPS1/IDNK/PGM2/ALDOC/DERA/TKT/PGLS
hsa03450	Non-homologous end-joining	6/3197	13/8019	0.421664715372084	0.62927193527714	0.367083840360463	MRE11/XRCC6/XRCC5/FEN1/POLL/POLM	6	http://www.kegg.jp/kegg-bin/show_pathway?hsa03450/MRE11/XRCC6/XRCC5/FEN1/POLL/POLM
hsa05140	Leishmaniasis	32/3197	77/8019	0.422761640727985	0.62927193527714	0.367083840360463	MAPK14/MAPK3/TGFB2/IL1B/PTGS2/MAPK1/ITGB1/TGFB1/FOS/EEF1A1/PTPN6/TNF/TRAF6/JUN/STAT1/MAP3K7/HLA-DRB1/HLA-DRB5/IRAK4/IRAK1/TLR4/TAB2/JAK2/TAB1/PRKCB/CYBB/HLA-DOB/C3/ELK1/TLR2/CR1/MARCKSL1	32	http://www.kegg.jp/kegg-bin/show_pathway?hsa05140/MAPK14/MAPK3/TGFB2/IL1B/PTGS2/MAPK1/ITGB1/TGFB1/FOS/EEF1A1/PTPN6/TNF/TRAF6/JUN/STAT1/MAP3K7/HLA-DRB1/HLA-DRB5/IRAK4/IRAK1/TLR4/TAB2/JAK2/TAB1/PRKCB/CYBB/HLA-DOB/C3/ELK1/TLR2/CR1/MARCKSL1
hsa05144	Malaria	21/3197	50/8019	0.431235892742547	0.637046565846654	0.371619147096467	TGFB2/IL1B/ICAM1/SDC1/TGFB1/CD40/CCL2/TNF/CD36/CD40LG/THBS1/TLR4/MET/IL18/HGF/TLR2/CXCL8/THBS2/CR1/VCAM1/SELE	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa05144/TGFB2/IL1B/ICAM1/SDC1/TGFB1/CD40/CCL2/TNF/CD36/CD40LG/THBS1/TLR4/MET/IL18/HGF/TLR2/CXCL8/THBS2/CR1/VCAM1/SELE
hsa00061	Fatty acid biosynthesis	8/3197	18/8019	0.431929405326369	0.637046565846654	0.371619147096467	ACSL4/ACSBG1/ACSL6/ACACA/ACSL3/ACSL1/FASN/OLAH	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00061/ACSL4/ACSBG1/ACSL6/ACACA/ACSL3/ACSL1/FASN/OLAH
hsa04927	Cortisol synthesis and secretion	27/3197	65/8019	0.437559309634363	0.642416622781361	0.374751753227517	PRKACB/MC2R/STAR/ATF2/CREB3/PDE8A/GNAS/ADCY9/ADCY2/GNAQ/ADCY5/GNA11/CREB1/SP1/HSD3B1/SCARB1/LDLR/CREB3L2/ATF6B/ATF4/CREB5/CACNA1C/ITPR2/KCNK2/ITPR1/KCNK3/CYP11A1	27	http://www.kegg.jp/kegg-bin/show_pathway?hsa04927/PRKACB/MC2R/STAR/ATF2/CREB3/PDE8A/GNAS/ADCY9/ADCY2/GNAQ/ADCY5/GNA11/CREB1/SP1/HSD3B1/SCARB1/LDLR/CREB3L2/ATF6B/ATF4/CREB5/CACNA1C/ITPR2/KCNK2/ITPR1/KCNK3/CYP11A1
hsa04978	Mineral absorption	24/3197	58/8019	0.456138915705284	0.666664569107723	0.388896717843514	VDR/ATP2B4/ATP7A/HEPH/STEAP2/SLC31A1/FTH1/FTL/ATOX1/SLC30A1/ATP1A2/TRPM7/ATP2B1/TRPM6/CYBRD1/SLC8A1/SLC8A3/ATP1B3/FXYD2/SLC46A1/SLC26A9/ATP1B4/MT1A/MT1E	24	http://www.kegg.jp/kegg-bin/show_pathway?hsa04978/VDR/ATP2B4/ATP7A/HEPH/STEAP2/SLC31A1/FTH1/FTL/ATOX1/SLC30A1/ATP1A2/TRPM7/ATP2B1/TRPM6/CYBRD1/SLC8A1/SLC8A3/ATP1B3/FXYD2/SLC46A1/SLC26A9/ATP1B4/MT1A/MT1E
hsa00564	Glycerophospholipid metabolism	40/3197	98/8019	0.461797986115094	0.671458320030979	0.391693137642318	PLPP3/LPCAT2/LPCAT1/CDIPT/CHPT1/AGPAT3/PLA2G5/DGKG/DGKE/DGKD/ETNK1/DGKH/GPD1L/LYPLA2/GPD2/PLA2G4A/PLPP4/PLA2G2F/PLA2G2D/GPAT4/LYPLA1/AGPAT5/MBOAT7/LCLAT1/PTDSS2/MBOAT2/PCYT1A/AGPAT4/PISD/CEPT1/PLD3/LPIN3/PLA2G2C/PLA2G12A/SELENOI/PLA2G4D/LPGAT1/PTDSS1/PNPLA6/LPCAT3	40	http://www.kegg.jp/kegg-bin/show_pathway?hsa00564/PLPP3/LPCAT2/LPCAT1/CDIPT/CHPT1/AGPAT3/PLA2G5/DGKG/DGKE/DGKD/ETNK1/DGKH/GPD1L/LYPLA2/GPD2/PLA2G4A/PLPP4/PLA2G2F/PLA2G2D/GPAT4/LYPLA1/AGPAT5/MBOAT7/LCLAT1/PTDSS2/MBOAT2/PCYT1A/AGPAT4/PISD/CEPT1/PLD3/LPIN3/PLA2G2C/PLA2G12A/SELENOI/PLA2G4D/LPGAT1/PTDSS1/PNPLA6/LPCAT3
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/3197	11/8019	0.46357648720405	0.671458320030979	0.391693137642318	VKORC1/VKORC1L1/TAT/COQ7/GGCX	5	http://www.kegg.jp/kegg-bin/show_pathway?hsa00130/VKORC1/VKORC1L1/TAT/COQ7/GGCX
hsa00052	Galactose metabolism	13/3197	31/8019	0.474434124477961	0.684117063421345	0.399077576511067	B4GALT1/B4GALT2/HK1/PFKP/PFKM/GCK/HK2/GALK1/PGM2/G6PC/GLA/AKR1B10/GALM	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00052/B4GALT1/B4GALT2/HK1/PFKP/PFKM/GCK/HK2/GALK1/PGM2/G6PC/GLA/AKR1B10/GALM
hsa04260	Cardiac muscle contraction	35/3197	86/8019	0.478225547248529	0.686519341161221	0.400478937812803	ATP1A2/ACTC1/ATP2A2/TRDN/TPM1/SLC8A1/CACNG7/CACNA1C/TNNI3/CYTB/SLC8A3/ATP1B3/TPM3/FXYD2/COX7A2L/TNNC1/TPM2/ASPH/CACNG6/CACNG1/CACNG8/UQCRH/COX6A1/COX1/CYC1/UQCRB/ATP1B4/UQCRFS1/COX6C/COX2/UQCR10/COX6B1/UQCRC1/COX5A/UQCR11	35	http://www.kegg.jp/kegg-bin/show_pathway?hsa04260/ATP1A2/ACTC1/ATP2A2/TRDN/TPM1/SLC8A1/CACNG7/CACNA1C/TNNI3/CYTB/SLC8A3/ATP1B3/TPM3/FXYD2/COX7A2L/TNNC1/TPM2/ASPH/CACNG6/CACNG1/CACNG8/UQCRH/COX6A1/COX1/CYC1/UQCRB/ATP1B4/UQCRFS1/COX6C/COX2/UQCR10/COX6B1/UQCRC1/COX5A/UQCR11
hsa04918	Thyroid hormone synthesis	30/3197	74/8019	0.497032929863071	0.706577666445101	0.412179899930497	PRKACB/HSPA5/ATF2/CREB3/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/HSP90B1/ADCY2/TTF2/GNAQ/ADCY5/IYD/GSR/CREB1/CREB3L2/ATF6B/ATF4/CREB5/ASGR2/ITPR2/ITPR1/ATP1B3/FXYD2/CANX/ATP1B4/SLC5A5/ASGR1	30	http://www.kegg.jp/kegg-bin/show_pathway?hsa04918/PRKACB/HSPA5/ATF2/CREB3/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/HSP90B1/ADCY2/TTF2/GNAQ/ADCY5/IYD/GSR/CREB1/CREB3L2/ATF6B/ATF4/CREB5/ASGR2/ITPR2/ITPR1/ATP1B3/FXYD2/CANX/ATP1B4/SLC5A5/ASGR1
hsa04924	Renin secretion	28/3197	69/8019	0.497572874572357	0.706577666445101	0.412179899930497	PRKACB/CTSB/EDN1/ADCYAP1R1/ADCYAP1/PPP3CA/CALM3/GNAI3/GNAI2/EDN3/CALM1/GNAS/PRKG2/NPR1/GNAQ/ADCY5/GUCY1A2/CREB1/CALM2/CACNA1C/KCNJ2/PDE3B/EDNRA/ITPR2/ITPR1/PPP3R1/PDE1A/CALML4	28	http://www.kegg.jp/kegg-bin/show_pathway?hsa04924/PRKACB/CTSB/EDN1/ADCYAP1R1/ADCYAP1/PPP3CA/CALM3/GNAI3/GNAI2/EDN3/CALM1/GNAS/PRKG2/NPR1/GNAQ/ADCY5/GUCY1A2/CREB1/CALM2/CACNA1C/KCNJ2/PDE3B/EDNRA/ITPR2/ITPR1/PPP3R1/PDE1A/CALML4
hsa03460	Fanconi anemia pathway	22/3197	54/8019	0.499440093403854	0.706577666445101	0.412179899930497	TOP3A/FANCC/FANCA/BRIP1/RAD51C/RMI1/MLH1/ERCC1/ERCC4/SLX4/HES1/FANCD2/RPA1/RAD51/RPA3/REV3L/PALB2/POLI/POLH/USP1/FAAP24/FANCF	22	http://www.kegg.jp/kegg-bin/show_pathway?hsa03460/TOP3A/FANCC/FANCA/BRIP1/RAD51C/RMI1/MLH1/ERCC1/ERCC4/SLX4/HES1/FANCD2/RPA1/RAD51/RPA3/REV3L/PALB2/POLI/POLH/USP1/FAAP24/FANCF
hsa00513	Various types of N-glycan biosynthesis	16/3197	39/8019	0.501896450931038	0.706577666445101	0.412179899930497	B4GALT1/ALG9/ALG3/ALG1/MAN1A2/MGAT1/B4GALNT3/MGAT4B/FUT8/B4GALT2/MAN1C1/HEXA/RPN2/DAD1/RPN1/ALG14	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa00513/B4GALT1/ALG9/ALG3/ALG1/MAN1A2/MGAT1/B4GALNT3/MGAT4B/FUT8/B4GALT2/MAN1C1/HEXA/RPN2/DAD1/RPN1/ALG14
hsa05012	Parkinson disease	57/3197	142/8019	0.505488152746199	0.706577666445101	0.412179899930497	UBB/PRKACB/VDAC2/PARK7/CASP3/UBE2J1/NDUFAB1/SDHD/SDHA/SDHC/PRKN/GNAI3/CYCS/GNAI2/UBA1/UBE2G2/ADCY5/NDUFS2/GNAL/UBA7/APAF1/SLC25A6/PPIF/NDUFA7/NDUFC2/VDAC1/CASP9/CYTB/ND4/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/COX5A/NDUFV3/UQCR11/NDUFB6	57	http://www.kegg.jp/kegg-bin/show_pathway?hsa05012/UBB/PRKACB/VDAC2/PARK7/CASP3/UBE2J1/NDUFAB1/SDHD/SDHA/SDHC/PRKN/GNAI3/CYCS/GNAI2/UBA1/UBE2G2/ADCY5/NDUFS2/GNAL/UBA7/APAF1/SLC25A6/PPIF/NDUFA7/NDUFC2/VDAC1/CASP9/CYTB/ND4/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/COX5A/NDUFV3/UQCR11/NDUFB6
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/3197	24/8019	0.505634030602829	0.706577666445101	0.412179899930497	HS6ST1/XYLT2/HS3ST5/EXT1/NDST1/GLCE/HS3ST2/B4GALT7/EXTL3/HS3ST1	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00534/HS6ST1/XYLT2/HS3ST5/EXT1/NDST1/GLCE/HS3ST2/B4GALT7/EXTL3/HS3ST1
hsa00770	Pantothenate and CoA biosynthesis	8/3197	19/8019	0.507510893545707	0.706577666445101	0.412179899930497	PANK2/PANK1/PANK3/ENPP1/COASY/AASDHPPT/PPCS/BCAT2	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00770/PANK2/PANK1/PANK3/ENPP1/COASY/AASDHPPT/PPCS/BCAT2
hsa04658	Th1 and Th2 cell differentiation	37/3197	92/8019	0.512395170975357	0.710316052467984	0.414360675873453	MAPK14/MAPK3/MAPK1/NOTCH1/JAG2/FOS/RBPJ/PPP3CA/MAPK10/NFATC2/JUN/STAT1/NOTCH3/MAF/RUNX3/NFATC3/DLL4/HLA-DRB1/HLA-DRB5/NOTCH2/IKBKG/MAPK8/MAPK9/IL2RB/IL2RA/JAK2/NFATC1/HLA-DOB/PLCG1/RBPJL/STAT5A/JAG1/CD3G/CD3D/PPP3R1/MAML1/MAML3	37	http://www.kegg.jp/kegg-bin/show_pathway?hsa04658/MAPK14/MAPK3/MAPK1/NOTCH1/JAG2/FOS/RBPJ/PPP3CA/MAPK10/NFATC2/JUN/STAT1/NOTCH3/MAF/RUNX3/NFATC3/DLL4/HLA-DRB1/HLA-DRB5/NOTCH2/IKBKG/MAPK8/MAPK9/IL2RB/IL2RA/JAK2/NFATC1/HLA-DOB/PLCG1/RBPJL/STAT5A/JAG1/CD3G/CD3D/PPP3R1/MAML1/MAML3
hsa04136	Autophagy - other	13/3197	32/8019	0.532188069672308	0.73460148078699	0.428527505494121	ATG7/MTOR/GABARAPL1/BECN1/PIK3C3/GABARAP/ATG9A/WIPI2/ATG12/ATG2A/ATG2B/ULK2/PPP2CB	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa04136/ATG7/MTOR/GABARAPL1/BECN1/PIK3C3/GABARAP/ATG9A/WIPI2/ATG12/ATG2A/ATG2B/ULK2/PPP2CB
hsa00900	Terpenoid backbone biosynthesis	9/3197	22/8019	0.540972758725233	0.743549791779788	0.433747475080926	HMGCS1/PCYOX1/HMGCR/ZMPSTE24/NUS1/FNTB/RCE1/GGPS1/ICMT	9	http://www.kegg.jp/kegg-bin/show_pathway?hsa00900/HMGCS1/PCYOX1/HMGCR/ZMPSTE24/NUS1/FNTB/RCE1/GGPS1/ICMT
hsa04612	Antigen processing and presentation	31/3197	78/8019	0.552097197271074	0.755624553892191	0.440791250274408	CTSB/HSP90AB1/HSPA2/CALR/HSPA5/PSME3/HSP90AA1/TNF/HSPA1A/CIITA/HLA-A/HLA-DRB1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/HSPA1B/HSPA8/HSPA6/HSPA4/CREB1/LGMN/HLA-DOB/NFYB/NFYC/NFYA/KLRD1/CANX/RFXAP/KLRC3	31	http://www.kegg.jp/kegg-bin/show_pathway?hsa04612/CTSB/HSP90AB1/HSPA2/CALR/HSPA5/PSME3/HSP90AA1/TNF/HSPA1A/CIITA/HLA-A/HLA-DRB1/HLA-B/HLA-C/TAPBP/HLA-E/HLA-DRB5/HSPA1B/HSPA8/HSPA6/HSPA4/CREB1/LGMN/HLA-DOB/NFYB/NFYC/NFYA/KLRD1/CANX/RFXAP/KLRC3
hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/3197	25/8019	0.570192134670451	0.77457595415694	0.451846491100186	PIGB/PIGQ/PIGP/PIGA/PIGG/PIGW/PIGF/PIGO/PIGM/PIGS	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00563/PIGB/PIGQ/PIGP/PIGA/PIGG/PIGW/PIGF/PIGO/PIGM/PIGS
hsa00520	Amino sugar and nucleotide sugar metabolism	19/3197	48/8019	0.570740176747219	0.77457595415694	0.451846491100186	PGM3/MPI/UXS1/GNPNAT1/HK1/UGDH/GCK/NAGK/HK2/GNE/GALK1/PGM2/HEXA/CYB5R4/GFPT2/CMAS/GFPT1/NANP/AMDHD2	19	http://www.kegg.jp/kegg-bin/show_pathway?hsa00520/PGM3/MPI/UXS1/GNPNAT1/HK1/UGDH/GCK/NAGK/HK2/GNE/GALK1/PGM2/HEXA/CYB5R4/GFPT2/CMAS/GFPT1/NANP/AMDHD2
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/3197	20/8019	0.57947785455239	0.783143711382518	0.456844465821968	XYLT2/CHSY1/UST/CHST15/CHST12/CHPF/B4GALT7/CHST11	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00532/XYLT2/CHSY1/UST/CHST15/CHST12/CHPF/B4GALT7/CHST11
hsa04020	Calcium signaling pathway	76/3197	193/8019	0.583304724719228	0.785030942017962	0.45794537598571	PTAFR/PRKACB/EGFR/PDGFRA/VDAC2/AVPR1A/PLCD1/PDGFRB/ATP2B4/PLCD3/PPP3CA/CAMK2A/CALM3/PLCE1/CACNA1A/ERBB2/ERBB3/ITPKB/CXCR4/P2RX7/ERBB4/CALM1/PRKCA/ADORA2B/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/ATP2A2/PHKG1/MYLK3/NOS1/GNAQ/ATP2B1/CAMK4/GNA11/GNAL/MYLK4/P2RX3/CAMK1D/PHKG2/TRDN/PHKB/PHKA1/SLC25A6/SLC8A1/PPIF/TPCN2/VDAC1/PLCG1/CALM2/GRIN2A/CHRM2/CACNA1C/TBXA2R/EDNRA/LTB4R2/BDKRB2/TACR3/PTGER3/ITPR2/ITPR1/SLC8A3/PLCG2/PPP3R1/GRM5/TNNC1/ORAI2/MCU/CACNA1E/ASPH/HTR7/CHRM3/PDE1A/CALML4	76	http://www.kegg.jp/kegg-bin/show_pathway?hsa04020/PTAFR/PRKACB/EGFR/PDGFRA/VDAC2/AVPR1A/PLCD1/PDGFRB/ATP2B4/PLCD3/PPP3CA/CAMK2A/CALM3/PLCE1/CACNA1A/ERBB2/ERBB3/ITPKB/CXCR4/P2RX7/ERBB4/CALM1/PRKCA/ADORA2B/GNAS/PRKCB/ADCY9/CAMK2G/ADCY2/ATP2A2/PHKG1/MYLK3/NOS1/GNAQ/ATP2B1/CAMK4/GNA11/GNAL/MYLK4/P2RX3/CAMK1D/PHKG2/TRDN/PHKB/PHKA1/SLC25A6/SLC8A1/PPIF/TPCN2/VDAC1/PLCG1/CALM2/GRIN2A/CHRM2/CACNA1C/TBXA2R/EDNRA/LTB4R2/BDKRB2/TACR3/PTGER3/ITPR2/ITPR1/SLC8A3/PLCG2/PPP3R1/GRM5/TNNC1/ORAI2/MCU/CACNA1E/ASPH/HTR7/CHRM3/PDE1A/CALML4
hsa00051	Fructose and mannose metabolism	13/3197	33/8019	0.5877568086268	0.787740453055835	0.45952596088315	ALDOA/MPI/HK1/PFKP/PFKFB3/PFKM/HK2/KHK/SORD/AKR1B10/TIGAR/ALDOC/TPI1	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00051/ALDOA/MPI/HK1/PFKP/PFKFB3/PFKM/HK2/KHK/SORD/AKR1B10/TIGAR/ALDOC/TPI1
hsa05146	Amoebiasis	40/3197	102/8019	0.591185128769591	0.789061142944537	0.460296381251661	TGFB2/IL1B/PRKACB/CASP3/TGFB1/RAB5A/TNF/TLR4/FN1/PRDX1/PIK3CB/PRKCA/PIK3R2/GNAS/PRKCB/RAB5B/PIK3CA/RAB5C/GNAQ/GNA11/GNAL/COL1A1/LAMA2/VCL/PIK3R1/LAMC1/ACTN4/COL4A4/ACTN1/COL1A2/COL3A1/TLR2/COL4A1/CXCL8/COL4A2/LAMA4/CXCL1/CXCL3/C8A/COL4A5	40	http://www.kegg.jp/kegg-bin/show_pathway?hsa05146/TGFB2/IL1B/PRKACB/CASP3/TGFB1/RAB5A/TNF/TLR4/FN1/PRDX1/PIK3CB/PRKCA/PIK3R2/GNAS/PRKCB/RAB5B/PIK3CA/RAB5C/GNAQ/GNA11/GNAL/COL1A1/LAMA2/VCL/PIK3R1/LAMC1/ACTN4/COL4A4/ACTN1/COL1A2/COL3A1/TLR2/COL4A1/CXCL8/COL4A2/LAMA4/CXCL1/CXCL3/C8A/COL4A5
hsa04723	Retrograde endocannabinoid signaling	58/3197	148/8019	0.598555322277301	0.790337342733568	0.461040848457907	MAPK14/MAPK3/PRKACB/PTGS2/MAPK1/GABRB1/NDUFAB1/MAPK10/NAPEPLD/GNAI3/CACNA1A/GNAI2/MAPK8/MAPK9/PRKCA/PRKCB/ADCY9/ADCY2/GNAQ/ADCY5/NDUFS2/NDUFA7/NDUFC2/GNB4/GNB2/GNG2/GABRA2/CACNA1C/KCNJ3/KCNJ5/GNG4/SLC17A8/GABRA5/ITPR2/ITPR1/ND4/FAAH/NDUFA2/GRM5/NDUFS7/GNG12/GABRA4/GABRQ/GABRB2/NDUFA4/NDUFA5/NDUFS1/GNB5/NDUFB5/ND1/KCNJ6/NDUFA12/GNG5/NDUFA10/NDUFA9/NDUFC2-KCTD14/NDUFV3/NDUFB6	58	http://www.kegg.jp/kegg-bin/show_pathway?hsa04723/MAPK14/MAPK3/PRKACB/PTGS2/MAPK1/GABRB1/NDUFAB1/MAPK10/NAPEPLD/GNAI3/CACNA1A/GNAI2/MAPK8/MAPK9/PRKCA/PRKCB/ADCY9/ADCY2/GNAQ/ADCY5/NDUFS2/NDUFA7/NDUFC2/GNB4/GNB2/GNG2/GABRA2/CACNA1C/KCNJ3/KCNJ5/GNG4/SLC17A8/GABRA5/ITPR2/ITPR1/ND4/FAAH/NDUFA2/GRM5/NDUFS7/GNG12/GABRA4/GABRQ/GABRB2/NDUFA4/NDUFA5/NDUFS1/GNB5/NDUFB5/ND1/KCNJ6/NDUFA12/GNG5/NDUFA10/NDUFA9/NDUFC2-KCTD14/NDUFV3/NDUFB6
hsa04726	Serotonergic synapse	45/3197	115/8019	0.599675526293705	0.790337342733568	0.461040848457907	SLC6A4/MAPK3/DUSP1/PRKACB/KRAS/PTGS2/MAPK1/APP/MAP2K1/GABRB1/CASP3/TRPC1/HRAS/NRAS/GNAI3/CACNA1A/BRAF/GNAI2/PRKCA/GNAS/PRKCB/GNAQ/ADCY5/GNB4/GNB2/GNG2/DDC/MAOA/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR2/ITPR1/CYP2C9/CYP2C19/PLA2G4A/GNG12/HTR7/GABRB2/GNB5/KCNJ6/GNG5/PLA2G4D/HTR1F	45	http://www.kegg.jp/kegg-bin/show_pathway?hsa04726/SLC6A4/MAPK3/DUSP1/PRKACB/KRAS/PTGS2/MAPK1/APP/MAP2K1/GABRB1/CASP3/TRPC1/HRAS/NRAS/GNAI3/CACNA1A/BRAF/GNAI2/PRKCA/GNAS/PRKCB/GNAQ/ADCY5/GNB4/GNB2/GNG2/DDC/MAOA/CACNA1C/KCNJ3/KCNJ5/GNG4/ITPR2/ITPR1/CYP2C9/CYP2C19/PLA2G4A/GNG12/HTR7/GABRB2/GNB5/KCNJ6/GNG5/PLA2G4D/HTR1F
hsa00190	Oxidative phosphorylation	52/3197	133/8019	0.605115948171596	0.790337342733568	0.461040848457907	NDUFAB1/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/COX17/SDHD/SDHA/SDHC/NDUFS2/COX10/LHPP/NDUFA7/NDUFC2/CYTB/ND4/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/COX5A/NDUFV3/UQCR11/NDUFB6	52	http://www.kegg.jp/kegg-bin/show_pathway?hsa00190/NDUFAB1/ATP6V1B2/ATP6V1F/ATP6AP1/ATP6V1C1/ATP6V1E1/ATP6V0D1/ATP6V0E1/ATP6V1G3/ATP6V1B1/ATP6V0A2/ATP6V1G1/ATP6V0E2/COX17/SDHD/SDHA/SDHC/NDUFS2/COX10/LHPP/NDUFA7/NDUFC2/CYTB/ND4/NDUFA2/NDUFS7/COX7A2L/UQCRH/NDUFA4/COX6A1/COX1/NDUFA5/CYC1/NDUFS1/UQCRB/UQCRFS1/COX6C/NDUFB5/ND1/NDUFA12/COX2/UQCR10/NDUFA10/NDUFA9/COX6B1/NDUFC2-KCTD14/ATP6/UQCRC1/COX5A/NDUFV3/UQCR11/NDUFB6
hsa03008	Ribosome biogenesis in eukaryotes	41/3197	105/8019	0.605171647822012	0.790337342733568	0.461040848457907	SPATA5/UTP14C/MDN1/RRP7A/PWP2/RAN/XPO1/RIOK2/EIF6/GTPBP4/CSNK2A1/NAT10/BMS1/GNL3L/GNL3/POP4/RMRP/RPP25/POP5/POP7/RPP30/REXO2/NXF1/FCF1/HEATR1/UTP4/UTP6/NOB1/RPP40/TCOF1/NOP58/DROSHA/IMP4/UTP15/UTP14A/RBM28/WDR3/WDR75/REXO1/NXT2/UTP18	41	http://www.kegg.jp/kegg-bin/show_pathway?hsa03008/SPATA5/UTP14C/MDN1/RRP7A/PWP2/RAN/XPO1/RIOK2/EIF6/GTPBP4/CSNK2A1/NAT10/BMS1/GNL3L/GNL3/POP4/RMRP/RPP25/POP5/POP7/RPP30/REXO2/NXF1/FCF1/HEATR1/UTP4/UTP6/NOB1/RPP40/TCOF1/NOP58/DROSHA/IMP4/UTP15/UTP14A/RBM28/WDR3/WDR75/REXO1/NXT2/UTP18
hsa00515	Mannose type O-glycan biosynthesis	9/3197	23/8019	0.606822479869736	0.790337342733568	0.461040848457907	B4GALT1/CHST10/FUT4/FKTN/POMGNT1/B3GALNT2/FUT9/B4GALT2/POMK	9	http://www.kegg.jp/kegg-bin/show_pathway?hsa00515/B4GALT1/CHST10/FUT4/FKTN/POMGNT1/B3GALNT2/FUT9/B4GALT2/POMK
hsa04964	Proximal tubule bicarbonate reclamation	9/3197	23/8019	0.606822479869736	0.790337342733568	0.461040848457907	GLUD2/ATP1A2/PCK1/GLUD1/ATP1B3/FXYD2/SLC25A10/SLC4A4/ATP1B4	9	http://www.kegg.jp/kegg-bin/show_pathway?hsa04964/GLUD2/ATP1A2/PCK1/GLUD1/ATP1B3/FXYD2/SLC25A10/SLC4A4/ATP1B4
hsa00640	Propanoate metabolism	13/3197	34/8019	0.640263909071402	0.830543143092622	0.484494777948767	ABAT/ACOX1/HADHA/ALDH6A1/ACACA/LDHA/PCCB/ACSS3/SUCLG2/LDHB/PCCA/DBT/ECHDC1	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00640/ABAT/ACOX1/HADHA/ALDH6A1/ACACA/LDHA/PCCB/ACSS3/SUCLG2/LDHB/PCCA/DBT/ECHDC1
hsa04724	Glutamatergic synapse	44/3197	114/8019	0.644253761892948	0.832375860365689	0.485563887910896	MAPK3/PRKACB/MAPK1/SLC38A2/TRPC1/PPP3CA/SLC1A1/GNAI3/CACNA1A/GNAI2/SHANK3/PRKCA/DLG4/GNAS/PRKCB/ADCY9/GLUL/GRK2/GRK3/ADCY2/GNAQ/ADCY5/GNB4/GNB2/SLC1A2/GNG2/SLC1A7/SLC38A1/GRIN2A/CACNA1C/KCNJ3/GNG4/GRIK3/SLC17A8/HOMER2/ITPR2/ITPR1/PLA2G4A/PPP3R1/GRM5/GNG12/GNB5/GNG5/PLA2G4D	44	http://www.kegg.jp/kegg-bin/show_pathway?hsa04724/MAPK3/PRKACB/MAPK1/SLC38A2/TRPC1/PPP3CA/SLC1A1/GNAI3/CACNA1A/GNAI2/SHANK3/PRKCA/DLG4/GNAS/PRKCB/ADCY9/GLUL/GRK2/GRK3/ADCY2/GNAQ/ADCY5/GNB4/GNB2/SLC1A2/GNG2/SLC1A7/SLC38A1/GRIN2A/CACNA1C/KCNJ3/GNG4/GRIK3/SLC17A8/HOMER2/ITPR2/ITPR1/PLA2G4A/PPP3R1/GRM5/GNG12/GNB5/GNG5/PLA2G4D
hsa00760	Nicotinate and nicotinamide metabolism	14/3197	37/8019	0.659382595859042	0.848528201045699	0.494986305970931	SIRT1/NAMPT/NMNAT2/NMNAT1/SIRT3/NT5C3A/NNT/NT5C1B/NT5C2/ENPP1/NADSYN1/PNP/QPRT/NT5C1B-RDH14	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa00760/SIRT1/NAMPT/NMNAT2/NMNAT1/SIRT3/NT5C3A/NNT/NT5C1B/NT5C2/ENPP1/NADSYN1/PNP/QPRT/NT5C1B-RDH14
hsa00730	Thiamine metabolism	6/3197	16/8019	0.667399309910291	0.855436417067555	0.499016192455898	ALPL/NFS1/AK2/AK4/ALPI/ACP1	6	http://www.kegg.jp/kegg-bin/show_pathway?hsa00730/ALPL/NFS1/AK2/AK4/ALPI/ACP1
hsa04217	Necroptosis	61/3197	159/8019	0.680267260817079	0.868483498987813	0.506627167406936	PARP1/IL1B/TNFSF10/BCL2/CASP8/VDAC2/HSP90AB1/BAX/BIRC3/BIRC2/SPATA2/STAT3/FTH1/FTL/VPS4A/CHMP2A/CHMP1B/TNFAIP3/BID/CAMK2A/HSP90AA1/HMGB1/TNF/MAPK10/STAT1/SQSTM1/NLRP3/DNM1L/PYCARD/MAPK8/FAS/MAPK9/TLR4/CYLD/EIF2AK2/JAK2/GLUD2/GLUL/TRPM7/CAMK2G/GLUD1/CYBB/XIAP/CHMP3/STAT2/SLC25A6/CAPN1/IFNAR1/PPIA/VDAC1/STAT5A/TICAM1/PGAM5/PLA2G4A/IFNB1/TNFRSF10B/TNFRSF10A/TRADD/IFNAR2/PLA2G4D/RNF103-CHMP3	61	http://www.kegg.jp/kegg-bin/show_pathway?hsa04217/PARP1/IL1B/TNFSF10/BCL2/CASP8/VDAC2/HSP90AB1/BAX/BIRC3/BIRC2/SPATA2/STAT3/FTH1/FTL/VPS4A/CHMP2A/CHMP1B/TNFAIP3/BID/CAMK2A/HSP90AA1/HMGB1/TNF/MAPK10/STAT1/SQSTM1/NLRP3/DNM1L/PYCARD/MAPK8/FAS/MAPK9/TLR4/CYLD/EIF2AK2/JAK2/GLUD2/GLUL/TRPM7/CAMK2G/GLUD1/CYBB/XIAP/CHMP3/STAT2/SLC25A6/CAPN1/IFNAR1/PPIA/VDAC1/STAT5A/TICAM1/PGAM5/PLA2G4A/IFNB1/TNFRSF10B/TNFRSF10A/TRADD/IFNAR2/PLA2G4D/RNF103-CHMP3
hsa04913	Ovarian steroidogenesis	19/3197	51/8019	0.697805316081285	0.887366602733288	0.517642567669085	PRKACB/PTGS2/CYP1A1/IGF1/STAR/ACOT2/IGF1R/GNAS/ADCY9/HSD17B1/ADCY2/ADCY5/HSD3B1/CYP1B1/SCARB1/LDLR/PLA2G4A/CYP11A1/PLA2G4D	19	http://www.kegg.jp/kegg-bin/show_pathway?hsa04913/PRKACB/PTGS2/CYP1A1/IGF1/STAR/ACOT2/IGF1R/GNAS/ADCY9/HSD17B1/ADCY2/ADCY5/HSD3B1/CYP1B1/SCARB1/LDLR/PLA2G4A/CYP11A1/PLA2G4D
hsa04975	Fat digestion and absorption	15/3197	41/8019	0.719826551681704	0.911780298796825	0.531884221882456	PLPP3/APOB/SLC27A4/CD36/ABCA1/PLA2G5/ABCG8/SCARB1/DGAT1/PLA2G2F/PLA2G2D/FABP2/PLA2G2C/PLA2G12A/MOGAT3	15	http://www.kegg.jp/kegg-bin/show_pathway?hsa04975/PLPP3/APOB/SLC27A4/CD36/ABCA1/PLA2G5/ABCG8/SCARB1/DGAT1/PLA2G2F/PLA2G2D/FABP2/PLA2G2C/PLA2G12A/MOGAT3
hsa00450	Selenocompound metabolism	6/3197	17/8019	0.732647524610934	0.919033356826021	0.536115270887592	SEPSECS/CTH/PAPSS1/SEPHS2/SEPHS1/SCLY	6	http://www.kegg.jp/kegg-bin/show_pathway?hsa00450/SEPSECS/CTH/PAPSS1/SEPHS2/SEPHS1/SCLY
hsa00910	Nitrogen metabolism	6/3197	17/8019	0.732647524610934	0.919033356826021	0.536115270887592	CPS1/GLUD2/GLUL/GLUD1/CA6/CA8	6	http://www.kegg.jp/kegg-bin/show_pathway?hsa00910/CPS1/GLUD2/GLUL/GLUD1/CA6/CA8
hsa00650	Butanoate metabolism	10/3197	28/8019	0.736933868166995	0.919033356826021	0.536115270887592	ABAT/HMGCS1/HADHA/BDH2/ACSM2B/ALDH5A1/OXCT1/BDH1/HMGCLL1/L2HGDH	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00650/ABAT/HMGCS1/HADHA/BDH2/ACSM2B/ALDH5A1/OXCT1/BDH1/HMGCLL1/L2HGDH
hsa04744	Phototransduction	10/3197	28/8019	0.736933868166995	0.919033356826021	0.536115270887592	GNAT1/CALM3/CNGB1/CALM1/GRK7/CALM2/PDE6B/PDE6A/GUCA1B/CALML4	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa04744/GNAT1/CALM3/CNGB1/CALM1/GRK7/CALM2/PDE6B/PDE6A/GUCA1B/CALML4
hsa00620	Pyruvate metabolism	14/3197	39/8019	0.746837043395346	0.927801403910372	0.541230084080028	LDHD/ACACA/LDHA/ALDH1B1/LDHB/PCK1/PKM/ALDH2/ALDH9A1/GLO1/MDH2/PDHA1/PDHB/DLAT	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa00620/LDHD/ACACA/LDHA/ALDH1B1/LDHB/PCK1/PKM/ALDH2/ALDH9A1/GLO1/MDH2/PDHA1/PDHB/DLAT
hsa00340	Histidine metabolism	8/3197	23/8019	0.759052553310601	0.937420812924764	0.546841536625494	FTCD/ALDH1B1/ALDH2/MAOA/ALDH9A1/ALDH3A1/CNDP1/ASPA	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00340/FTCD/ALDH1B1/ALDH2/MAOA/ALDH9A1/ALDH3A1/CNDP1/ASPA
hsa04974	Protein digestion and absorption	35/3197	95/8019	0.760384684168075	0.937420812924764	0.546841536625494	SLC38A2/SLC1A1/ATP1A2/SLC8A1/COL1A1/KCNQ1/SLC36A1/COL6A1/SLC7A7/COL4A4/COL12A1/COL18A1/COL14A1/COL5A2/COL1A2/COL3A1/COL4A1/COL10A1/COL9A2/KCNE3/COL4A2/COL5A1/SLC1A5/SLC8A3/ATP1B3/FXYD2/KCNN4/SLC7A8/ELN/KCNK5/SLC16A10/SLC36A2/COL4A5/ATP1B4/COL5A3	35	http://www.kegg.jp/kegg-bin/show_pathway?hsa04974/SLC38A2/SLC1A1/ATP1A2/SLC8A1/COL1A1/KCNQ1/SLC36A1/COL6A1/SLC7A7/COL4A4/COL12A1/COL18A1/COL14A1/COL5A2/COL1A2/COL3A1/COL4A1/COL10A1/COL9A2/KCNE3/COL4A2/COL5A1/SLC1A5/SLC8A3/ATP1B3/FXYD2/KCNN4/SLC7A8/ELN/KCNK5/SLC16A10/SLC36A2/COL4A5/ATP1B4/COL5A3
hsa02010	ABC transporters	16/3197	45/8019	0.770307553338876	0.941883660580109	0.549444925024734	CFTR/ABCD1/ABCD2/ABCA1/ABCC6/ABCB11/ABCG8/ABCC5/ABCB7/ABCB9/ABCC9/ABCC10/ABCC1/ABCG2/ABCC12/ABCA2	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa02010/CFTR/ABCD1/ABCD2/ABCA1/ABCC6/ABCB11/ABCG8/ABCC5/ABCB7/ABCB9/ABCC9/ABCC10/ABCC1/ABCG2/ABCC12/ABCA2
hsa00790	Folate biosynthesis	9/3197	26/8019	0.770701747589945	0.941883660580109	0.549444925024734	ALPL/GPHN/FPGS/ALPI/AKR1B10/CBR1/MOCS2/MOCOS/PCBD2	9	http://www.kegg.jp/kegg-bin/show_pathway?hsa00790/ALPL/GPHN/FPGS/ALPI/AKR1B10/CBR1/MOCS2/MOCOS/PCBD2
hsa05143	African trypanosomiasis	13/3197	37/8019	0.773940807924995	0.941883660580109	0.549444925024734	IL1B/ICAM1/TNF/FAS/PRKCA/F2RL1/IL18/PRKCB/GNAQ/THOP1/LAMA4/VCAM1/SELE	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa05143/IL1B/ICAM1/TNF/FAS/PRKCA/F2RL1/IL18/PRKCB/GNAQ/THOP1/LAMA4/VCAM1/SELE
hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/3197	15/8019	0.779867904927946	0.941883660580109	0.549444925024734	SLC33A1/ST3GAL2/ST3GAL1/ST3GAL5/HEXA	5	http://www.kegg.jp/kegg-bin/show_pathway?hsa00604/SLC33A1/ST3GAL2/ST3GAL1/ST3GAL5/HEXA
hsa00280	Valine, leucine and isoleucine degradation	17/3197	48/8019	0.780851526393014	0.941883660580109	0.549444925024734	ABAT/HMGCS1/HADHA/ALDH6A1/MCCC2/ALDH1B1/PCCB/ALDH2/PCCA/ALDH9A1/ACAA2/OXCT1/AUH/HADHB/BCAT2/HMGCLL1/DBT	17	http://www.kegg.jp/kegg-bin/show_pathway?hsa00280/ABAT/HMGCS1/HADHA/ALDH6A1/MCCC2/ALDH1B1/PCCB/ALDH2/PCCA/ALDH9A1/ACAA2/OXCT1/AUH/HADHB/BCAT2/HMGCLL1/DBT
hsa00591	Linoleic acid metabolism	10/3197	29/8019	0.781500993917861	0.941883660580109	0.549444925024734	PLA2G5/CYP1A2/CYP2C9/CYP2C19/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00591/PLA2G5/CYP1A2/CYP2C9/CYP2C19/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D
hsa04977	Vitamin digestion and absorption	8/3197	24/8019	0.804811055250961	0.961576516122481	0.560932691497227	APOB/ABCC1/MMACHC/SCARB1/LRAT/SLC46A1/BTD/SLC19A3	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa04977/APOB/ABCC1/MMACHC/SCARB1/LRAT/SLC46A1/BTD/SLC19A3
hsa05321	Inflammatory bowel disease (IBD)	23/3197	65/8019	0.806762811107046	0.961576516122481	0.560932691497227	TGFB2/IL1B/TGFB1/STAT3/FOXP3/TNF/SMAD3/JUN/STAT1/SMAD2/MAF/HLA-DRB1/HLA-DRB5/TLR4/IL18/NFATC1/IL18RAP/HLA-DOB/RORA/TLR2/IL21R/IL23R/TLR5	23	http://www.kegg.jp/kegg-bin/show_pathway?hsa05321/TGFB2/IL1B/TGFB1/STAT3/FOXP3/TNF/SMAD3/JUN/STAT1/SMAD2/MAF/HLA-DRB1/HLA-DRB5/TLR4/IL18/NFATC1/IL18RAP/HLA-DOB/RORA/TLR2/IL21R/IL23R/TLR5
hsa04514	Cell adhesion molecules (CAMs)	54/3197	147/8019	0.806913955831549	0.961576516122481	0.560932691497227	CADM1/ICAM1/SDC1/NECTIN3/ITGB1/ITGB8/PTPRC/CD40/CD28/NECTIN1/HLA-A/HLA-DRB1/HLA-B/HLA-C/NCAM1/HLA-E/HLA-DRB5/GLG1/CD40LG/CDH2/HLA-DOB/SDC3/SDC4/CNTNAP2/CDH1/NEO1/NFASC/NRXN3/ITGA8/CDH4/CLDN1/PVR/F11R/VCAM1/CD274/PDCD1/ICOSLG/CD226/CD276/TIGIT/VSIR/LRRC4/SELE/ITGA9/JAM2/CD99/CLDN16/NCAM2/PTPRF/CADM3/CLDN7/CLDN23/MPZL1/NEGR1	54	http://www.kegg.jp/kegg-bin/show_pathway?hsa04514/CADM1/ICAM1/SDC1/NECTIN3/ITGB1/ITGB8/PTPRC/CD40/CD28/NECTIN1/HLA-A/HLA-DRB1/HLA-B/HLA-C/NCAM1/HLA-E/HLA-DRB5/GLG1/CD40LG/CDH2/HLA-DOB/SDC3/SDC4/CNTNAP2/CDH1/NEO1/NFASC/NRXN3/ITGA8/CDH4/CLDN1/PVR/F11R/VCAM1/CD274/PDCD1/ICOSLG/CD226/CD276/TIGIT/VSIR/LRRC4/SELE/ITGA9/JAM2/CD99/CLDN16/NCAM2/PTPRF/CADM3/CLDN7/CLDN23/MPZL1/NEGR1
hsa05340	Primary immunodeficiency	13/3197	38/8019	0.809748645155773	0.961576516122481	0.560932691497227	PTPRC/CD40/IL7R/CIITA/IKBKG/CD40LG/BTK/AIRE/RAG1/CD3D/TNFRSF13C/UNG/RFXAP	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa05340/PTPRC/CD40/IL7R/CIITA/IKBKG/CD40LG/BTK/AIRE/RAG1/CD3D/TNFRSF13C/UNG/RFXAP
hsa00920	Sulfur metabolism	3/3197	10/8019	0.83073059893679	0.980246447688875	0.571823738426947	PAPSS1/SUOX/BPNT1	3	http://www.kegg.jp/kegg-bin/show_pathway?hsa00920/PAPSS1/SUOX/BPNT1
hsa04973	Carbohydrate digestion and absorption	16/3197	47/8019	0.83315402676363	0.980246447688875	0.571823738426947	AKT3/AKT1/PIK3CB/PIK3R2/HK1/AKT2/PRKCB/PIK3CA/ATP1A2/HK2/G6PC/PIK3R1/ATP1B3/FXYD2/SLC37A4/ATP1B4	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa04973/AKT3/AKT1/PIK3CB/PIK3R2/HK1/AKT2/PRKCB/PIK3CA/ATP1A2/HK2/G6PC/PIK3R1/ATP1B3/FXYD2/SLC37A4/ATP1B4
hsa00350	Tyrosine metabolism	12/3197	36/8019	0.834575148961117	0.980246447688875	0.571823738426947	COMT/ADH4/GOT1/DDC/MAOA/LRTOMT/ADH5/ALDH3A1/TAT/TYRP1/FAH/FAHD1	12	http://www.kegg.jp/kegg-bin/show_pathway?hsa00350/COMT/ADH4/GOT1/DDC/MAOA/LRTOMT/ADH5/ALDH3A1/TAT/TYRP1/FAH/FAHD1
hsa00592	alpha-Linolenic acid metabolism	8/3197	25/8019	0.843643918789267	0.987307919452657	0.575943026175739	ACOX1/PLA2G5/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00592/ACOX1/PLA2G5/PLA2G4A/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D
hsa00410	beta-Alanine metabolism	10/3197	31/8019	0.853703657952467	0.99547394050053	0.580706649338748	ABAT/ACOX1/HADHA/ALDH6A1/ALDH1B1/ALDH2/ALDH9A1/ALDH3A1/CNDP1/SMOX	10	http://www.kegg.jp/kegg-bin/show_pathway?hsa00410/ABAT/ACOX1/HADHA/ALDH6A1/ALDH1B1/ALDH2/ALDH9A1/ALDH3A1/CNDP1/SMOX
hsa04622	RIG-I-like receptor signaling pathway	24/3197	70/8019	0.860444494698589	0.999725078372821	0.583186537489767	MAPK14/CASP8/DDX3X/ATG12/TNF/MAPK10/TRAF6/MAP3K7/RNF125/IKBKG/MAPK8/MAPK9/CYLD/PIN1/TBK1/AZI2/CXCL10/CXCL8/IFNB1/TRAF3/MAVS/TRADD/TANK/SIKE1	24	http://www.kegg.jp/kegg-bin/show_pathway?hsa04622/MAPK14/CASP8/DDX3X/ATG12/TNF/MAPK10/TRAF6/MAP3K7/RNF125/IKBKG/MAPK8/MAPK9/CYLD/PIN1/TBK1/AZI2/CXCL10/CXCL8/IFNB1/TRAF3/MAVS/TRADD/TANK/SIKE1
hsa00360	Phenylalanine metabolism	5/3197	17/8019	0.871966022306251	1	0.583346912172071	GOT1/DDC/MAOA/ALDH3A1/TAT	5	http://www.kegg.jp/kegg-bin/show_pathway?hsa00360/GOT1/DDC/MAOA/ALDH3A1/TAT
hsa04940	Type I diabetes mellitus	14/3197	43/8019	0.873209473547012	1	0.583346912172071	IL1B/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/FAS/HSPD1/HLA-DOB/PTPRN2/CPE	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa04940/IL1B/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/FAS/HSPD1/HLA-DOB/PTPRN2/CPE
hsa04950	Maturity onset diabetes of the young	8/3197	26/8019	0.876062661544521	1	0.583346912172071	HNF4A/HES1/GCK/FOXA2/BHLHA15/NEUROD1/PAX4/ONECUT1	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa04950/HNF4A/HES1/GCK/FOXA2/BHLHA15/NEUROD1/PAX4/ONECUT1
hsa05330	Allograft rejection	12/3197	38/8019	0.888570857659693	1	0.583346912172071	CD40/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD40LG/FAS/HLA-DOB	12	http://www.kegg.jp/kegg-bin/show_pathway?hsa05330/CD40/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD40LG/FAS/HLA-DOB
hsa00330	Arginine and proline metabolism	16/3197	50/8019	0.901958072448699	1	0.583346912172071	SMS/ALDH1B1/NOS1/PRODH/ALDH2/GOT1/MAOA/ALDH9A1/SAT1/ODC1/P4HA1/SRM/CNDP1/AGMAT/AMD1/SMOX	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa00330/SMS/ALDH1B1/NOS1/PRODH/ALDH2/GOT1/MAOA/ALDH9A1/SAT1/ODC1/P4HA1/SRM/CNDP1/AGMAT/AMD1/SMOX
hsa00053	Ascorbate and aldarate metabolism	8/3197	27/8019	0.902725666970995	1	0.583346912172071	ALDH1B1/UGDH/ALDH2/ALDH9A1/UGT2B28/UGT2B10/UGT2B4/MIOX	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00053/ALDH1B1/UGDH/ALDH2/ALDH9A1/UGT2B28/UGT2B10/UGT2B4/MIOX
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/3197	27/8019	0.902725666970995	1	0.583346912172071	B4GALT1/A4GALT/B3GALNT1/B3GALT5/FUT4/FUT9/B4GALT2/B3GNT2	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00601/B4GALT1/A4GALT/B3GALNT1/B3GALT5/FUT4/FUT9/B4GALT2/B3GNT2
hsa00480	Glutathione metabolism	18/3197	56/8019	0.908318800107123	1	0.583346912172071	GGT7/RRM2/SMS/GCLM/GSTP1/IDH2/PGD/G6PD/GSR/ODC1/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/SRM/CHAC1/GSTK1	18	http://www.kegg.jp/kegg-bin/show_pathway?hsa00480/GGT7/RRM2/SMS/GCLM/GSTP1/IDH2/PGD/G6PD/GSR/ODC1/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/SRM/CHAC1/GSTK1
hsa00380	Tryptophan metabolism	13/3197	42/8019	0.911871410738097	1	0.583346912172071	CYP1A1/HADHA/ALDH1B1/ALDH2/CYP1B1/HAAO/AANAT/DDC/MAOA/ALDH9A1/CYP1A2/DHTKD1/DLST	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00380/CYP1A1/HADHA/ALDH1B1/ALDH2/CYP1B1/HAAO/AANAT/DDC/MAOA/ALDH9A1/CYP1A2/DHTKD1/DLST
hsa00860	Porphyrin and chlorophyll metabolism	13/3197	42/8019	0.911871410738097	1	0.583346912172071	HEPH/MMAB/COX10/FXN/GUSB/UROS/UGT2B28/UGT2B10/UGT2B4/BLVRA/FECH/UROD/CPOX	13	http://www.kegg.jp/kegg-bin/show_pathway?hsa00860/HEPH/MMAB/COX10/FXN/GUSB/UROS/UGT2B28/UGT2B10/UGT2B4/BLVRA/FECH/UROD/CPOX
hsa04623	Cytosolic DNA-sensing pathway	20/3197	63/8019	0.928294356857111	1	0.583346912172071	IL1B/PYCARD/IKBKG/CCL5/IL18/TBK1/POLR3G/POLR3D/POLR2E/POLR2F/POLR3A/POLR3H/POLR3K/POLR1D/POLR3E/POLR3F/CXCL10/ADAR/IFNB1/MAVS	20	http://www.kegg.jp/kegg-bin/show_pathway?hsa04623/IL1B/PYCARD/IKBKG/CCL5/IL18/TBK1/POLR3G/POLR3D/POLR2E/POLR2F/POLR3A/POLR3H/POLR3K/POLR1D/POLR3E/POLR3F/CXCL10/ADAR/IFNB1/MAVS
hsa04972	Pancreatic secretion	34/3197	102/8019	0.928882076717222	1	0.583346912172071	SLC4A2/CFTR/ATP2B4/TRPC1/RAC1/RAB8A/PLA2G5/RAP1B/PRKCA/RAP1A/GNAS/PRKCB/ADCY9/RHOA/ATP1A2/ADCY2/ATP2A2/GNAQ/ADCY5/RAB3D/ATP2B1/KCNQ1/TPCN2/ITPR2/ITPR1/ATP1B3/PLA2G2F/PLA2G2D/FXYD2/CHRM3/SLC4A4/ATP1B4/PLA2G2C/PLA2G12A	34	http://www.kegg.jp/kegg-bin/show_pathway?hsa04972/SLC4A2/CFTR/ATP2B4/TRPC1/RAC1/RAB8A/PLA2G5/RAP1B/PRKCA/RAP1A/GNAS/PRKCB/ADCY9/RHOA/ATP1A2/ADCY2/ATP2A2/GNAQ/ADCY5/RAB3D/ATP2B1/KCNQ1/TPCN2/ITPR2/ITPR1/ATP1B3/PLA2G2F/PLA2G2D/FXYD2/CHRM3/SLC4A4/ATP1B4/PLA2G2C/PLA2G12A
hsa04061	Viral protein interaction with cytokine and cytokine receptor	33/3197	100/8019	0.936377086894522	1	0.583346912172071	TNFSF10/CSF1/CCR6/CCL2/TNF/CCL16/CCR5/CCL5/CXCR4/IL2RB/ACKR3/CCL22/IL2RA/IL18/IL18RAP/CXCL10/TNFSF14/CXCL12/IL6R/IL6ST/CXCL8/CCR2/CCR4/CXCL5/CXCL1/CXCL14/CXCL3/IL20RB/TNFRSF1B/TNFRSF10B/TNFRSF10A/IL10RB/TNFRSF10D	33	http://www.kegg.jp/kegg-bin/show_pathway?hsa04061/TNFSF10/CSF1/CCR6/CCL2/TNF/CCL16/CCR5/CCL5/CXCR4/IL2RB/ACKR3/CCL22/IL2RA/IL18/IL18RAP/CXCL10/TNFSF14/CXCL12/IL6R/IL6ST/CXCL8/CCR2/CCR4/CXCL5/CXCL1/CXCL14/CXCL3/IL20RB/TNFRSF1B/TNFRSF10B/TNFRSF10A/IL10RB/TNFRSF10D
hsa05332	Graft-versus-host disease	12/3197	41/8019	0.941842865837542	1	0.583346912172071	IL1B/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/FAS/HLA-DOB/KLRD1	12	http://www.kegg.jp/kegg-bin/show_pathway?hsa05332/IL1B/CD28/TNF/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/FAS/HLA-DOB/KLRD1
hsa04970	Salivary secretion	29/3197	90/8019	0.946521669828678	1	0.583346912172071	PRKACB/SLC4A2/ATP2B4/CALM3/VAMP2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/PRKG2/ADCY2/PRKG1/NOS1/GNAQ/ADCY5/ATP2B1/GUCY1A2/LYZ/CALM2/ITPR2/ITPR1/ATP1B3/FXYD2/KCNN4/CHRM3/ATP1B4/CALML4	29	http://www.kegg.jp/kegg-bin/show_pathway?hsa04970/PRKACB/SLC4A2/ATP2B4/CALM3/VAMP2/CALM1/PRKCA/GNAS/PRKCB/ADCY9/ATP1A2/PRKG2/ADCY2/PRKG1/NOS1/GNAQ/ADCY5/ATP2B1/GUCY1A2/LYZ/CALM2/ITPR2/ITPR1/ATP1B3/FXYD2/KCNN4/CHRM3/ATP1B4/CALML4
hsa00983	Drug metabolism - other enzymes	25/3197	79/8019	0.948581236100432	1	0.583346912172071	UMPS/RRM2/GSTP1/NME6/TK1/ITPA/NME2/IMPDH1/GMPS/UCK2/UCK1/HPRT1/CMPK1/IMPDH2/DUT/GUSB/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/CES2	25	http://www.kegg.jp/kegg-bin/show_pathway?hsa00983/UMPS/RRM2/GSTP1/NME6/TK1/ITPA/NME2/IMPDH1/GMPS/UCK2/UCK1/HPRT1/CMPK1/IMPDH2/DUT/GUSB/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/CES2
hsa04610	Complement and coagulation cascades	27/3197	85/8019	0.951678940239728	1	0.583346912172071	CD55/CD59/FGB/FGA/SERPINF2/FGG/C3/F2/CLU/SERPINE1/C6/ITGAX/F3/CR1/BDKRB2/F2RL3/F2RL2/PLAT/PLAUR/CFB/C8A/SERPING1/SERPINC1/TFPI/C1S/PROCR/F9	27	http://www.kegg.jp/kegg-bin/show_pathway?hsa04610/CD55/CD59/FGB/FGA/SERPINF2/FGG/C3/F2/CLU/SERPINE1/C6/ITGAX/F3/CR1/BDKRB2/F2RL3/F2RL2/PLAT/PLAUR/CFB/C8A/SERPING1/SERPINC1/TFPI/C1S/PROCR/F9
hsa00630	Glyoxylate and dicarboxylate metabolism	8/3197	30/8019	0.955418675114287	1	0.583346912172071	GLUL/PCCB/PCCA/SHMT1/SHMT2/ACO1/MDH2/CS	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00630/GLUL/PCCB/PCCA/SHMT1/SHMT2/ACO1/MDH2/CS
hsa04672	Intestinal immune network for IgA production	14/3197	49/8019	0.963706057202757	1	0.583346912172071	TGFB1/CD40/CD28/TNFSF13/HLA-DRB1/HLA-DRB5/CD40LG/CXCR4/HLA-DOB/PIGR/CXCL12/ICOSLG/TNFSF13B/TNFRSF13C	14	http://www.kegg.jp/kegg-bin/show_pathway?hsa04672/TGFB1/CD40/CD28/TNFSF13/HLA-DRB1/HLA-DRB5/CD40LG/CXCR4/HLA-DOB/PIGR/CXCL12/ICOSLG/TNFSF13B/TNFRSF13C
hsa00260	Glycine, serine and threonine metabolism	11/3197	40/8019	0.963808992224328	1	0.583346912172071	CBS/CTH/CHDH/PHGDH/PSPH/SHMT1/SHMT2/MAOA/PGAM1/PSAT1/PGAM4	11	http://www.kegg.jp/kegg-bin/show_pathway?hsa00260/CBS/CTH/CHDH/PHGDH/PSPH/SHMT1/SHMT2/MAOA/PGAM1/PSAT1/PGAM4
hsa05033	Nicotine addiction	11/3197	40/8019	0.963808992224328	1	0.583346912172071	GABRB1/CACNA1A/CHRNB2/GRIN2A/GABRA2/CHRNA6/SLC17A8/GABRA5/GABRA4/GABRQ/GABRB2	11	http://www.kegg.jp/kegg-bin/show_pathway?hsa05033/GABRB1/CACNA1A/CHRNB2/GRIN2A/GABRA2/CHRNA6/SLC17A8/GABRA5/GABRA4/GABRQ/GABRB2
hsa00430	Taurine and hypotaurine metabolism	2/3197	11/8019	0.969259845843771	1	0.583346912172071	GGT7/ADO	2	http://www.kegg.jp/kegg-bin/show_pathway?hsa00430/GGT7/ADO
hsa04976	Bile secretion	21/3197	72/8019	0.978103502874756	1	0.583346912172071	PRKACB/SLC4A2/RXRA/SLC2A1/CFTR/HMGCR/GNAS/ADCY9/ATP1A2/ABCB11/ABCG8/ADCY2/ADCY5/ABCG2/SCARB1/LDLR/ATP1B3/FXYD2/SLC4A4/ATP1B4/UGT2B4	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa04976/PRKACB/SLC4A2/RXRA/SLC2A1/CFTR/HMGCR/GNAS/ADCY9/ATP1A2/ABCB11/ABCG8/ADCY2/ADCY5/ABCG2/SCARB1/LDLR/ATP1B3/FXYD2/SLC4A4/ATP1B4/UGT2B4
hsa00500	Starch and sucrose metabolism	9/3197	36/8019	0.979815497398636	1	0.583346912172071	HK1/GCK/HK2/ENPP1/GYS2/PGM2L1/AGL/PGM2/G6PC	9	http://www.kegg.jp/kegg-bin/show_pathway?hsa00500/HK1/GCK/HK2/ENPP1/GYS2/PGM2L1/AGL/PGM2/G6PC
hsa04614	Renin-angiotensin system	5/3197	23/8019	0.980573078944981	1	0.583346912172071	LNPEP/THOP1/CTSA/KLK2/NLN	5	http://www.kegg.jp/kegg-bin/show_pathway?hsa04614/LNPEP/THOP1/CTSA/KLK2/NLN
hsa00040	Pentose and glucuronate interconversions	8/3197	34/8019	0.985840244470962	1	0.583346912172071	UGDH/SORD/XYLB/GUSB/AKR1B10/UGT2B28/UGT2B10/UGT2B4	8	http://www.kegg.jp/kegg-bin/show_pathway?hsa00040/UGDH/SORD/XYLB/GUSB/AKR1B10/UGT2B28/UGT2B10/UGT2B4
hsa00120	Primary bile acid biosynthesis	3/3197	17/8019	0.987410397076789	1	0.583346912172071	CYP7B1/SCP2/CYP8B1	3	http://www.kegg.jp/kegg-bin/show_pathway?hsa00120/CYP7B1/SCP2/CYP8B1
hsa00511	Other glycan degradation	3/3197	18/8019	0.991583213904621	1	0.583346912172071	GBA2/MAN2B2/HEXA	3	http://www.kegg.jp/kegg-bin/show_pathway?hsa00511/GBA2/MAN2B2/HEXA
hsa00140	Steroid hormone biosynthesis	15/3197	60/8019	0.994825058718325	1	0.583346912172071	CYP1A1/CYP7B1/SRD5A1/COMT/HSD17B1/HSD3B1/CYP1B1/LRTOMT/CYP1A2/HSD17B12/CYP11A1/UGT2B28/UGT2B10/UGT2B4/SRD5A3	15	http://www.kegg.jp/kegg-bin/show_pathway?hsa00140/CYP1A1/CYP7B1/SRD5A1/COMT/HSD17B1/HSD3B1/CYP1B1/LRTOMT/CYP1A2/HSD17B12/CYP11A1/UGT2B28/UGT2B10/UGT2B4/SRD5A3
hsa05034	Alcoholism	57/3197	184/8019	0.995379831950399	1	0.583346912172071	MAPK3/PRKACB/KRAS/GRB2/MAPK1/SOS1/HDAC4/MAP2K1/FOSB/HDAC2/HRAS/ATF2/CALM3/PPP1CB/PKIA/HDAC11/HDAC1/HDAC7/HDAC8/HDAC5/CREB3/NRAS/NTRK2/GNAI3/PPP1CC/BRAF/GNAI2/CAMKK2/SHC3/CALM1/ADORA2B/GNAS/CAMKK1/ADCY5/CAMK4/CREB1/GNB4/GNB2/SOS2/CREB3L2/BDNF/CALM2/ATF6B/ATF4/CREB5/GNG2/SLC29A2/SLC29A1/DDC/MAOA/GRIN2A/GNG4/GNG12/SHC4/GNB5/GNG5/CALML4	57	http://www.kegg.jp/kegg-bin/show_pathway?hsa05034/MAPK3/PRKACB/KRAS/GRB2/MAPK1/SOS1/HDAC4/MAP2K1/FOSB/HDAC2/HRAS/ATF2/CALM3/PPP1CB/PKIA/HDAC11/HDAC1/HDAC7/HDAC8/HDAC5/CREB3/NRAS/NTRK2/GNAI3/PPP1CC/BRAF/GNAI2/CAMKK2/SHC3/CALM1/ADORA2B/GNAS/CAMKK1/ADCY5/CAMK4/CREB1/GNB4/GNB2/SOS2/CREB3L2/BDNF/CALM2/ATF6B/ATF4/CREB5/GNG2/SLC29A2/SLC29A1/DDC/MAOA/GRIN2A/GNG4/GNG12/SHC4/GNB5/GNG5/CALML4
hsa00980	Metabolism of xenobiotics by cytochrome P450	20/3197	76/8019	0.995406759609854	1	0.583346912172071	CYP1A1/GSTP1/ADH4/CYP1B1/CBR1/ADH5/CYP1A2/ALDH3A1/CYP2C9/GSTM4/CYP2B6/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/AKR7A2/GSTK1	20	http://www.kegg.jp/kegg-bin/show_pathway?hsa00980/CYP1A1/GSTP1/ADH4/CYP1B1/CBR1/ADH5/CYP1A2/ALDH3A1/CYP2C9/GSTM4/CYP2B6/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/AKR7A2/GSTK1
hsa00830	Retinol metabolism	17/3197	67/8019	0.995714222249992	1	0.583346912172071	CYP1A1/RDH10/CYP26B1/ADH4/LRAT/ALDH1A2/RDH11/ADH5/RETSAT/CYP27C1/DGAT1/CYP1A2/CYP2C9/CYP2B6/UGT2B28/UGT2B10/UGT2B4	17	http://www.kegg.jp/kegg-bin/show_pathway?hsa00830/CYP1A1/RDH10/CYP26B1/ADH4/LRAT/ALDH1A2/RDH11/ADH5/RETSAT/CYP27C1/DGAT1/CYP1A2/CYP2C9/CYP2B6/UGT2B28/UGT2B10/UGT2B4
hsa05310	Asthma	6/3197	31/8019	0.995885173883619	1	0.583346912172071	CD40/TNF/HLA-DRB1/HLA-DRB5/CD40LG/HLA-DOB	6	http://www.kegg.jp/kegg-bin/show_pathway?hsa05310/CD40/TNF/HLA-DRB1/HLA-DRB5/CD40LG/HLA-DOB
hsa00982	Drug metabolism - cytochrome P450	18/3197	72/8019	0.997339784564752	1	0.583346912172071	GSTP1/ADH4/MAOA/ADH5/CYP1A2/ALDH3A1/CYP2C9/CYP2C19/GSTM4/CYP2B6/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/GSTK1	18	http://www.kegg.jp/kegg-bin/show_pathway?hsa00982/GSTP1/ADH4/MAOA/ADH5/CYP1A2/ALDH3A1/CYP2C9/CYP2C19/GSTM4/CYP2B6/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/GSTK1
hsa00590	Arachidonic acid metabolism	15/3197	63/8019	0.997683197416073	1	0.583346912172071	PTGIS/PTGS2/PTGES2/PLA2G5/CBR1/CYP2C9/CYP2C19/PLA2G4A/CYP2U1/CYP2B6/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D	15	http://www.kegg.jp/kegg-bin/show_pathway?hsa00590/PTGIS/PTGS2/PTGES2/PLA2G5/CBR1/CYP2C9/CYP2C19/PLA2G4A/CYP2U1/CYP2B6/PLA2G2F/PLA2G2D/PLA2G2C/PLA2G12A/PLA2G4D
hsa05204	Chemical carcinogenesis	21/3197	82/8019	0.9977348644215	1	0.583346912172071	PTGS2/CYP1A1/ARNT/GSTP1/ADH4/CYP1B1/CBR1/ADH5/CYP1A2/ALDH3A1/CYP2C9/CYP2C19/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/GSTK1	21	http://www.kegg.jp/kegg-bin/show_pathway?hsa05204/PTGS2/CYP1A1/ARNT/GSTP1/ADH4/CYP1B1/CBR1/ADH5/CYP1A2/ALDH3A1/CYP2C9/CYP2C19/GSTM4/GSTM3/GSTO1/MGST3/GSTO2/UGT2B28/UGT2B10/UGT2B4/GSTK1
hsa04640	Hematopoietic cell lineage	26/3197	99/8019	0.998454493309246	1	0.583346912172071	IL1B/CSF1/KIT/ITGA5/KITLG/ITGA3/ITGA2/TFRC/IL7R/TNF/CD36/HLA-DRB1/HLA-DRB5/CD55/CD59/ITGA1/IL2RA/IL11/CD44/HLA-DOB/ITGB3/IL6R/CR1/CD3G/CD3D/GP5	26	http://www.kegg.jp/kegg-bin/show_pathway?hsa04640/IL1B/CSF1/KIT/ITGA5/KITLG/ITGA3/ITGA2/TFRC/IL7R/TNF/CD36/HLA-DRB1/HLA-DRB5/CD55/CD59/ITGA1/IL2RA/IL11/CD44/HLA-DOB/ITGB3/IL6R/CR1/CD3G/CD3D/GP5
hsa05320	Autoimmune thyroid disease	11/3197	53/8019	0.999100071731106	1	0.583346912172071	CD40/CD28/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD40LG/FAS/HLA-DOB	11	http://www.kegg.jp/kegg-bin/show_pathway?hsa05320/CD40/CD28/HLA-A/HLA-DRB1/HLA-B/HLA-C/HLA-E/HLA-DRB5/CD40LG/FAS/HLA-DOB
hsa04060	Cytokine-cytokine receptor interaction	87/3197	294/8019	0.999925360629137	1	0.583346912172071	TGFB2/IL1B/TNFSF10/TGFBR1/CSF1/TGFBR2/ACVR1B/CCR6/BMPR2/INHBA/BMP7/LIF/LEP/ACVR1/PRLR/TGFB1/NODAL/BMPR1A/AMH/CD40/TNFSF13/IL7R/CCL2/TNF/BMP2/ACVR2B/CCL16/CCR5/CD40LG/CCL5/IL31RA/FAS/BMP3/BMP8A/EDA2R/CXCR4/IL2RB/ACKR3/IL1F10/CCL22/IL2RA/IL11/GDF11/IL18/EDAR/BMP8B/IL18RAP/IFNAR1/CXCL10/TNFSF14/CXCL12/MPL/NGFR/IL6R/IL6ST/CXCL8/CCR2/IL21R/CXCL16/CCR4/CNTF/CXCL5/CXCL1/CXCL14/CXCL3/IFNB1/IL23R/TNFSF9/TNFSF8/TNFSF13B/TNFRSF21/IL20RB/TNFRSF13C/IL17RA/TNFRSF1B/IL1RAP/TNFSF15/TNFRSF10B/TNFRSF10A/IFNAR2/LIFR/IFNLR1/IL10RB/TNFRSF10D/OSMR/TNFRSF9/IL13RA1	87	http://www.kegg.jp/kegg-bin/show_pathway?hsa04060/TGFB2/IL1B/TNFSF10/TGFBR1/CSF1/TGFBR2/ACVR1B/CCR6/BMPR2/INHBA/BMP7/LIF/LEP/ACVR1/PRLR/TGFB1/NODAL/BMPR1A/AMH/CD40/TNFSF13/IL7R/CCL2/TNF/BMP2/ACVR2B/CCL16/CCR5/CD40LG/CCL5/IL31RA/FAS/BMP3/BMP8A/EDA2R/CXCR4/IL2RB/ACKR3/IL1F10/CCL22/IL2RA/IL11/GDF11/IL18/EDAR/BMP8B/IL18RAP/IFNAR1/CXCL10/TNFSF14/CXCL12/MPL/NGFR/IL6R/IL6ST/CXCL8/CCR2/IL21R/CXCL16/CCR4/CNTF/CXCL5/CXCL1/CXCL14/CXCL3/IFNB1/IL23R/TNFSF9/TNFSF8/TNFSF13B/TNFRSF21/IL20RB/TNFRSF13C/IL17RA/TNFRSF1B/IL1RAP/TNFSF15/TNFRSF10B/TNFRSF10A/IFNAR2/LIFR/IFNLR1/IL10RB/TNFRSF10D/OSMR/TNFRSF9/IL13RA1
hsa04742	Taste transduction	16/3197	83/8019	0.999984092765045	1	0.583346912172071	PRKACB/P2RY1/CACNA1A/HCN4/P2RX3/GABRA2/CACNA1C/TAS2R5/GABRA5/GABRA4/SCNN1G/CHRM3/KCNK5/PDE1A/GABBR2/HTR1F	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa04742/PRKACB/P2RY1/CACNA1A/HCN4/P2RX3/GABRA2/CACNA1C/TAS2R5/GABRA5/GABRA4/SCNN1G/CHRM3/KCNK5/PDE1A/GABBR2/HTR1F
hsa00970	Aminoacyl-tRNA biosynthesis	7/3197	66/8019	0.999999978637203	1	0.583346912172071	DARS2/FARSA/SEPSECS/WARS2/RARS2/FARSB/PARS2	7	http://www.kegg.jp/kegg-bin/show_pathway?hsa00970/DARS2/FARSA/SEPSECS/WARS2/RARS2/FARSB/PARS2
hsa05150	Staphylococcus aureus infection	12/3197	96/8019	0.999999999393711	1	0.583346912172071	PTAFR/ICAM1/HLA-DRB1/HLA-DRB5/FPR1/FPR2/FGG/HLA-DOB/C3/CFB/C1S/KRT33B	12	http://www.kegg.jp/kegg-bin/show_pathway?hsa05150/PTAFR/ICAM1/HLA-DRB1/HLA-DRB5/FPR1/FPR2/FGG/HLA-DOB/C3/CFB/C1S/KRT33B
hsa05322	Systemic lupus erythematosus	16/3197	133/8019	0.999999999999821	1	0.583346912172071	CD40/CD28/TNF/HLA-DRB1/HLA-DRB5/CD40LG/SNRPD3/SNRPD1/HLA-DOB/C3/ACTN4/ACTN1/GRIN2A/C6/C8A/C1S	16	http://www.kegg.jp/kegg-bin/show_pathway?hsa05322/CD40/CD28/TNF/HLA-DRB1/HLA-DRB5/CD40LG/SNRPD3/SNRPD1/HLA-DOB/C3/ACTN4/ACTN1/GRIN2A/C6/C8A/C1S
hsa04080	Neuroactive ligand-receptor interaction	74/3197	340/8019	0.999999999999857	1	0.583346912172071	PTAFR/OPRL1/TAC1/EDN1/AVPR1A/SSTR2/GABRB1/ADCYAP1R1/LEP/ADCYAP1/MC2R/THRA/ADRA2B/RLN2/PRLR/OPRK1/SSTR3/P2RY1/ADM/THRB/NR3C1/TRPV1/HRH4/P2RX7/EDN3/FPR1/CALCR/F2RL1/FPR2/ADORA2B/S1PR2/P2RX3/PARD3/C3/CHRNB2/F2/GLRA3/S1PR1/GRIN2A/CHRM2/GABRA2/CHRNA6/CHRNA5/TBXA2R/APLN/EDNRA/GAL/ADORA3/LTB4R2/GRIK3/BDKRB2/GLP1R/F2RL3/VIPR1/GLP2R/TACR3/OPRD1/NPFFR1/F2RL2/PTGER3/GABRA5/GRM5/GABRA4/GABRQ/HTR7/GABRB2/CHRM3/GPR50/GRID1/GABBR2/LPAR2/GPR156/HTR1F/NPY4R	74	http://www.kegg.jp/kegg-bin/show_pathway?hsa04080/PTAFR/OPRL1/TAC1/EDN1/AVPR1A/SSTR2/GABRB1/ADCYAP1R1/LEP/ADCYAP1/MC2R/THRA/ADRA2B/RLN2/PRLR/OPRK1/SSTR3/P2RY1/ADM/THRB/NR3C1/TRPV1/HRH4/P2RX7/EDN3/FPR1/CALCR/F2RL1/FPR2/ADORA2B/S1PR2/P2RX3/PARD3/C3/CHRNB2/F2/GLRA3/S1PR1/GRIN2A/CHRM2/GABRA2/CHRNA6/CHRNA5/TBXA2R/APLN/EDNRA/GAL/ADORA3/LTB4R2/GRIK3/BDKRB2/GLP1R/F2RL3/VIPR1/GLP2R/TACR3/OPRD1/NPFFR1/F2RL2/PTGER3/GABRA5/GRM5/GABRA4/GABRQ/HTR7/GABRB2/CHRM3/GPR50/GRID1/GABBR2/LPAR2/GPR156/HTR1F/NPY4R
hsa04740	Olfactory transduction	23/3197	448/8019	1	1	0.583346912172071	PRKACB/ARRB1/ARRB2/RGS2/CAMK2A/CALM3/CNGB1/CNGA2/CALM1/GRK2/GRK3/PRKG2/CAMK2G/PRKG1/GNAL/SLC8A1/CALM2/SLC8A3/OR2C3/OR7D2/SLC24A4/PDE1A/CALML4	23	http://www.kegg.jp/kegg-bin/show_pathway?hsa04740/PRKACB/ARRB1/ARRB2/RGS2/CAMK2A/CALM3/CNGB1/CNGA2/CALM1/GRK2/GRK3/PRKG2/CAMK2G/PRKG1/GNAL/SLC8A1/CALM2/SLC8A3/OR2C3/OR7D2/SLC24A4/PDE1A/CALML4