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immunotherapy_versus_chemotherapy_for_NSCL.rm5
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<?xml version="1.0" encoding="ISO-8859-1" standalone="no"?> <COCHRANE_REVIEW DESCRIPTION="" DOI="" GROUP_ID="" ID="093918083114154288" MERGED_FROM="" MODIFIED="2019-08-04 14:42:16 +0800" MODIFIED_BY="[Empty name]" REVIEW_NO="" REVMAN_SUB_VERSION="5.3.5 " REVMAN_VERSION="5" SPLIT_FROM="" STAGE="P" STATUS="A" TYPE="INTERVENTION" VERSION_NO="0.0"> <COVER_SHEET MODIFIED="2018-08-31 14:15:42 +0800" MODIFIED_BY="[Empty name]"> <TITLE MODIFIED="2018-08-31 14:15:42 +0800" MODIFIED_BY="[Empty name]">immunotherapy versus chemotherapy for NSCLC</TITLE> <CONTACT> <PERSON ID="????" ROLE="UNKNOWN"> <PREFIX/> <FIRST_NAME/> <MIDDLE_INITIALS/> <LAST_NAME/> <SUFFIX/> <POSITION/> <EMAIL_1/> <EMAIL_2/> <URL/> <MOBILE_PHONE/> <ADDRESS> <DEPARTMENT/> <ORGANISATION/> <ADDRESS_1/> <ADDRESS_2/> <CITY/> <ZIP/> <REGION/> <COUNTRY CODE="NONE">Other</COUNTRY> <PHONE_1/> <PHONE_2/> <FAX_1/> <FAX_2/> </ADDRESS> <FOOTNOTE/> </PERSON> </CONTACT> <CREATORS> <PERSON ID="????" ROLE="AUTHOR"> <PREFIX/> <FIRST_NAME/> <MIDDLE_INITIALS/> <LAST_NAME/> <SUFFIX/> <POSITION/> <EMAIL_1/> <EMAIL_2/> <URL/> <MOBILE_PHONE/> <ADDRESS> <DEPARTMENT/> <ORGANISATION/> <ADDRESS_1/> <ADDRESS_2/> <CITY/> <ZIP/> <REGION/> <COUNTRY CODE="NONE">Other</COUNTRY> <PHONE_1/> <PHONE_2/> <FAX_1/> <FAX_2/> </ADDRESS> <FOOTNOTE/> </PERSON> </CREATORS> <DATES> <UP_TO_DATE> <DATE DAY="" MONTH="" YEAR=""/> </UP_TO_DATE> <LAST_SEARCH> <DATE DAY="" MONTH="" YEAR=""/> </LAST_SEARCH> <NEXT_STAGE> <DATE DAY="" MONTH="" YEAR=""/> </NEXT_STAGE> <PROTOCOL_PUBLISHED ISSUE="" YEAR=""/> <REVIEW_PUBLISHED ISSUE="" YEAR=""/> <LAST_CITATION_ISSUE ISSUE="" YEAR=""/> </DATES> <WHATS_NEW/> <HISTORY/> <SOURCES_OF_SUPPORT> <INTERNAL_SOURCES/> <EXTERNAL_SOURCES/> </SOURCES_OF_SUPPORT> <MESH_TERMS VERIFIED="NO"/> <KEYWORDS/> </COVER_SHEET> <MAIN_TEXT> <SUMMARY> <TITLE>[Summary title]</TITLE> <SUMMARY_BODY> <P>[Summary text]</P> </SUMMARY_BODY> </SUMMARY> <ABSTRACT> <ABS_BACKGROUND/> <ABS_OBJECTIVES/> <ABS_SEARCH_STRATEGY/> <ABS_SELECTION_CRITERIA/> <ABS_DATA_COLLECTION/> <ABS_RESULTS/> <ABS_CONCLUSIONS/> </ABSTRACT> <BODY> <BACKGROUND> <CONDITION/> <INTERVENTION/> <THEORY/> <IMPORTANCE/> </BACKGROUND> <OBJECTIVES/> <METHODS> <SELECTION_CRITERIA> <CRIT_STUDIES/> <CRIT_PARTICIPANTS/> <CRIT_INTERVENTIONS/> <CRIT_OUTCOMES> <CRIT_OUTCOMES_PRIMARY/> <CRIT_OUTCOMES_SECONDARY/> </CRIT_OUTCOMES> </SELECTION_CRITERIA> <SEARCH_METHODS> <ELECTRONIC_SEARCHES/> <OTHER_SEARCHES/> </SEARCH_METHODS> <DATA_COLLECTION> <STUDY_SELECTION/> <DATA_EXTRACTION/> <QUALITY_ASSESSMENT/> <EFFECT_MEASURES/> <UNIT_OF_ANALYSIS/> <MISSING_DATA/> <HETEROGENEITY_ASSESSMENT/> <BIAS_ASSESSMENT/> <DATA_SYNTHESIS/> <SUBGROUP_ANALYSIS/> <SENSITIVITY_ANALYSIS/> </DATA_COLLECTION> </METHODS> <RESULTS> <STUDY_DESCRIPTION> <SEARCH_RESULTS/> <INCLUDED_STUDIES_DESCR/> <EXCLUDED_STUDIES_DESCR/> </STUDY_DESCRIPTION> <STUDY_QUALITY> <ALLOCATION/> <BLINDING/> <EXCLUSIONS/> <SELECTIVE_REPORTING/> <OTHER_BIAS_SOURCES/> </STUDY_QUALITY> <INTERVENTION_EFFECTS/> </RESULTS> <DISCUSSION> <SUMMARY_OF_RESULTS/> <APPLICABILITY_OF_FINDINGS/> <QUALITY_OF_EVIDENCE/> <POTENTIAL_BIASES/> <AGREEMENT/> </DISCUSSION> <CONCLUSIONS> <IMPLICATIONS_PRACTICE/> <IMPLICATIONS_RESEARCH/> </CONCLUSIONS> </BODY> <ACKNOWLEDGEMENTS/> <CONFLICT_OF_INTEREST/> <CONTRIBUTIONS/> <PRO_REV_DIFF/> <PUBLIC_NOTES/> </MAIN_TEXT> <STUDIES_AND_REFERENCES MODIFIED="2019-08-04 14:36:34 +0800" MODIFIED_BY="[Empty name]"> <STUDIES MODIFIED="2019-08-04 14:36:34 +0800" MODIFIED_BY="[Empty name]"> <INCLUDED_STUDIES MODIFIED="2019-08-04 14:36:34 +0800" MODIFIED_BY="[Empty name]"> <STUDY DATA_SOURCE="PUB" ID="STD-D.P.-Carbone-2017" MODIFIED="2018-08-31 14:17:39 +0800" MODIFIED_BY="[Empty name]" NAME="D.P. Carbone 2017" YEAR="2017"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_" MODIFIED="2019-08-04 14:35:26 +0800" MODIFIED_BY="[Empty name]" NAME="Hossein Borghaei 2018 (checkmate 227)" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_" MODIFIED="2019-08-04 14:35:45 +0800" MODIFIED_BY="[Empty name]" NAME="Hossein Borghaei 2018 (keynote 021G)" YEAR="2016"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Howard-West-2019" MODIFIED="2019-08-04 14:36:34 +0800" MODIFIED_BY="[Empty name]" NAME="Howard West 2019" YEAR="2019"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-L.Gandhi-2018" MODIFIED="2018-08-31 14:19:05 +0800" MODIFIED_BY="[Empty name]" NAME="L.Gandhi 2018" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Luis-G.-Paz_x002d_Ares-2018" MODIFIED="2018-09-04 16:56:17 +0800" MODIFIED_BY="[Empty name]" NAME="Luis G. Paz-Ares 2018" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Martin-Reck-2016" MODIFIED="2018-08-31 14:18:04 +0800" MODIFIED_BY="[Empty name]" NAME="Martin Reck 2016" YEAR="2016"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Robert-M.-Jotte-2018" MODIFIED="2018-08-31 14:20:33 +0800" MODIFIED_BY="[Empty name]" NAME="Robert M. Jotte 2018" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Tony-S-K-Mok-2019" MODIFIED="2019-08-04 14:22:13 +0800" MODIFIED_BY="[Empty name]" NAME="Tony S K Mok 2019" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> <STUDY DATA_SOURCE="PUB" ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018" MODIFIED="2018-10-16 17:16:18 +0800" MODIFIED_BY="[Empty name]" NAME="Vassiliki A. Papadimitrakopoulou 2018" YEAR="2018"> <REFERENCE PRIMARY="NO" TYPE="JOURNAL_ARTICLE"> <IDENTIFIERS/> </REFERENCE> <IDENTIFIERS/> </STUDY> </INCLUDED_STUDIES> <EXCLUDED_STUDIES/> <AWAITING_STUDIES/> <ONGOING_STUDIES/> </STUDIES> <OTHER_REFERENCES> <ADDITIONAL_REFERENCES/> <OTHER_VERSIONS_REFERENCES/> <PENDING_REFERENCES/> </OTHER_REFERENCES> </STUDIES_AND_REFERENCES> <CHARACTERISTICS_OF_STUDIES MODIFIED="2019-08-04 14:42:15 +0800" MODIFIED_BY="[Empty name]"> <CHARACTERISTICS_OF_INCLUDED_STUDIES MODIFIED="2019-08-04 14:42:15 +0800" MODIFIED_BY="[Empty name]" SORT_BY="STUDY" USER_DEF_1_ENABLED="NO" USER_DEF_2_ENABLED="NO" USER_DEF_3_ENABLED="NO"> <INCLUDED_CHAR STUDY_ID="STD-D.P.-Carbone-2017"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Howard-West-2019"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-L.Gandhi-2018"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Martin-Reck-2016"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Robert-M.-Jotte-2018"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Tony-S-K-Mok-2019"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <INCLUDED_CHAR STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <CHAR_METHODS/> <CHAR_PARTICIPANTS/> <CHAR_INTERVENTIONS/> <CHAR_OUTCOMES/> <CHAR_NOTES/> </INCLUDED_CHAR> <FOOTNOTES/> </CHARACTERISTICS_OF_INCLUDED_STUDIES> <CHARACTERISTICS_OF_EXCLUDED_STUDIES SORT_BY="STUDY"> <FOOTNOTES/> </CHARACTERISTICS_OF_EXCLUDED_STUDIES> <CHARACTERISTICS_OF_AWAITING_STUDIES SORT_BY="STUDY" USER_DEF_1_ENABLED="NO" USER_DEF_2_ENABLED="NO" USER_DEF_3_ENABLED="NO"> <FOOTNOTES/> </CHARACTERISTICS_OF_AWAITING_STUDIES> <CHARACTERISTICS_OF_ONGOING_STUDIES SORT_BY="STUDY" USER_DEF_1_ENABLED="NO" USER_DEF_2_ENABLED="NO" USER_DEF_3_ENABLED="NO"> <FOOTNOTES/> </CHARACTERISTICS_OF_ONGOING_STUDIES> </CHARACTERISTICS_OF_STUDIES> <QUALITY_ITEMS MODIFIED="2019-08-04 14:42:15 +0800" MODIFIED_BY="[Empty name]"> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-01" LEVEL="STUDY" MODIFIED="2019-08-04 14:38:45 +0800" MODIFIED_BY="[Empty name]" NO="1"> <NAME>Random sequence generation (selection bias)</NAME> <DESCRIPTION> <P>Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence</P> </DESCRIPTION> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:09:42 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:29:04 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 19:24:35 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:38:45 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:39:25 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:44:21 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:54:37 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:57:28 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:19:22 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-10-16 17:19:07 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-02" LEVEL="STUDY" MODIFIED="2019-08-04 14:39:21 +0800" MODIFIED_BY="[Empty name]" NO="2"> <NAME>Allocation concealment (selection bias)</NAME> <DESCRIPTION> <P>Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment</P> </DESCRIPTION> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:15:43 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION> <P>未详细描述</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:32:31 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 19:40:52 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION> <P>部分隐蔽分组</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:39:21 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION> <P>未详细描述</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:40:40 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:44:22 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:54:42 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 21:01:36 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:32:54 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION> <P>未详细描述</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-10-16 17:23:23 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION> <P>试验数据不全</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-03" LEVEL="GROUP" MODIFIED="2019-08-04 14:42:06 +0800" MODIFIED_BY="[Empty name]" NO="3"> <NAME>Blinding of participants and personnel (performance bias)</NAME> <DESCRIPTION> <P>Performance bias due to knowledge of the allocated interventions by participants and personnel during the study</P> </DESCRIPTION> <QUALITY_ITEM_DATA_ENTRY_GROUP ID="QIG-03.01" NO="1"> <NAME>All outcomes</NAME> </QUALITY_ITEM_DATA_ENTRY_GROUP> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:14:30 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:34:28 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 19:41:47 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2019-08-04 14:42:06 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:39:21 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:44:25 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:54:44 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:59:52 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-09-15 20:23:02 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-03.01" MODIFIED="2018-10-16 17:23:32 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-04" LEVEL="GROUP" MODIFIED="2019-08-04 14:42:08 +0800" MODIFIED_BY="[Empty name]" NO="4"> <NAME>Blinding of outcome assessment (detection bias)</NAME> <DESCRIPTION> <P>Detection bias due to knowledge of the allocated interventions by outcome assessors</P> </DESCRIPTION> <QUALITY_ITEM_DATA_ENTRY_GROUP ID="QIG-04.01" NO="1"> <NAME>All outcomes</NAME> </QUALITY_ITEM_DATA_ENTRY_GROUP> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:13:26 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:36:08 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION> <P>未详细描述</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 19:45:30 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2019-08-04 14:42:08 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:39:47 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:44:28 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:55:48 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 21:01:01 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-09-15 20:38:28 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-04.01" MODIFIED="2018-10-16 17:25:36 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION> <P>试验数据不全</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-05" LEVEL="GROUP" MODIFIED="2019-08-04 14:42:11 +0800" MODIFIED_BY="[Empty name]" NO="5"> <NAME>Incomplete outcome data (attrition bias)</NAME> <DESCRIPTION> <P>Attrition bias due to amount, nature or handling of incomplete outcome data</P> </DESCRIPTION> <QUALITY_ITEM_DATA_ENTRY_GROUP ID="QIG-05.01" NO="1"> <NAME>All outcomes</NAME> </QUALITY_ITEM_DATA_ENTRY_GROUP> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 20:16:42 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 20:36:43 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 19:47:50 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2019-08-04 14:42:11 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 20:42:13 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-10-23 18:56:18 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 20:56:00 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-09-15 20:57:38 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2019-08-04 14:24:03 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY GROUP_ID="QIG-05.01" MODIFIED="2018-10-16 17:26:00 +0800" MODIFIED_BY="[Empty name]" RESULT="NO" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION> <P>中期数据不完整</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-06" LEVEL="STUDY" MODIFIED="2019-08-04 14:42:13 +0800" MODIFIED_BY="[Empty name]" NO="6"> <NAME>Selective reporting (reporting bias)</NAME> <DESCRIPTION> <P>Reporting bias due to selective outcome reporting</P> </DESCRIPTION> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:17:56 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:36:34 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION> <P>试验未结束</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:08:10 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:42:13 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:42:17 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:47:17 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:56:44 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION> <P>未详细描述</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:57:30 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:22:45 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-10-16 17:26:29 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> </QUALITY_ITEM_DATA> </QUALITY_ITEM> <QUALITY_ITEM CORE_ITEM="YES" ID="QIT-07" LEVEL="STUDY" MODIFIED="2019-08-04 14:42:15 +0800" MODIFIED_BY="[Empty name]" NO="7"> <NAME>Other bias</NAME> <DESCRIPTION> <P>Bias due to problems not covered elsewhere in the table</P> </DESCRIPTION> <QUALITY_ITEM_DATA> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:16:48 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-D.P.-Carbone-2017"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:36:39 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_checkmate-227_x0029_"> <DESCRIPTION> <P>试验未结束</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:09:07 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Hossein-Borghaei-2018-_x0028_keynote-021G_x0029_"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:42:15 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Howard-West-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:42:21 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-L.Gandhi-2018"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:47:26 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Luis-G.-Paz_x002d_Ares-2018"> <DESCRIPTION> <P>试验未结束</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:56:34 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Martin-Reck-2016"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-09-15 20:57:44 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Robert-M.-Jotte-2018"> <DESCRIPTION> <P>试验未结束</P> </DESCRIPTION> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2019-08-04 14:23:52 +0800" MODIFIED_BY="[Empty name]" RESULT="YES" STUDY_ID="STD-Tony-S-K-Mok-2019"> <DESCRIPTION/> </QUALITY_ITEM_DATA_ENTRY> <QUALITY_ITEM_DATA_ENTRY MODIFIED="2018-10-16 17:26:57 +0800" MODIFIED_BY="[Empty name]" RESULT="UNKNOWN" STUDY_ID="STD-Vassiliki-A.-Papadimitrakopoulou-2018"> <DESCRIPTION> <P>试验数据不全</P> </DESCRIPTION> 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ID="FLOW_4" NAME="FIGURE" REVMAN_VERSION="5.1.0" TYPE="FLOWCHART"> <ALIAS ALIAS_ID="4"> <FLOWCHARTBOX TEXT="<p>Studies included in quantitative synthesis (meta-analysis)(n=10)</p>" WIDTH="140"> <FLOWCHARTBOX TEXT="<p>Studies assessed for eligibility(n=22)</p>" WIDTH="120"> <FLOWCHARTBOX TEXT="<p>Records after duplicates removed(n=556)</p>" WIDTH="120"> <FLOWCHARTBOX TEXT="<p>Studies identified through database searching in Pubmed,Embase and Cochrane Library(n=589)</p>" WIDTH="120"/> <FLOWCHARTBOX TEXT="<p>Additional records identified through Clinical Trial.gov and Conferences Abstract searching(n=134)</p>" WIDTH="120"/> <OUT TEXT="<p>Records excluded based on screening of titles and abstracts(n=530)</p><p>Clinical trial is ongoing(n=4)</p>" WIDTH="120"/> </FLOWCHARTBOX> <OUT TEXT="<p>Studies excluded(n=12)</p><p>Single-Arm studies(n=6)</p><p>Contained Ipilimumab's studies(n=5)</p><p>Combination therapy included bevacizumab(n=1)</p><p>No chemotherapy group(n=1)</p>" WIDTH="230"/> </FLOWCHARTBOX> </FLOWCHARTBOX> </ALIAS> </EXTENSION> </EXTENSIONS> </COCHRANE_REVIEW>