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Haley Delamora
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DrugResponsePrediction
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# drug_id Name Synonyms Targets Target pathway PubCHEM Sample Size Count
1 1242 (5Z)-7-Oxozeaenol 5Z-7-Oxozeaenol, LL-Z1640-2 TAK1 Other, kinases 9863776 945 266
2 179 5-Fluorouracil 5-FU Antimetabolite (DNA & RNA) Other 3385 968 266
3 86 A-443654 KIN001-139 AKT1, AKT2, AKT3 PI3K/MTOR signaling 10172943 425 266
4 55 A-770041 KIN001-111 LCK, FYN Other, kinases 9549184 426 266
5 1001 AICA Ribonucleotide AICAR, N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide AMPK agonist Metabolism 65110 872 266
6 171 AKT inhibitor VIII Akti-1/2 AKT1, AKT2, AKT3 PI3K/MTOR signaling 10196499 934 266
7 228 AKT inhibitor VIII Akti-1/2, KIN001-102 AKT1, AKT2, AKT3 PI3K/MTOR signaling 10196499 979 266
8 272 AR-42 HDAC-42, AR 42, AR42 HDAC1 Chromatin histone acetylation 6918848 965 266
9 207 AS601245 JNK1, JNK2, JNK2 JNK and p38 signaling 10109823 925 266
10 224 AS605240 KIN001-173, AS-605240 PI3Kgamma PI3K/MTOR signaling 5289247 975 266
11 219 AT-7519 AT7519 CDK1, CDK2, CDK4, CDK6, CDK9 Cell cycle 11338033 976 266
12 29 AZ628 AZ-628, AZ 628 BRAF ERK MAPK signaling 11676786 428 266
13 156 AZD6482 AZD 6482, AZD-6482, AK-55409 PI3Kbeta PI3K/MTOR signaling 44137675 933 266
14 1066 AZD6482 AZD 6482, AZD-6482, AK-55409 PI3Kbeta PI3K/MTOR signaling 44137675 931 266
15 1022 AZD7762 AZD-7762, AZD 7762 CHEK1, CHEK2 Cell cycle 11152667 881 266
16 1059 AZD8055 AZD-8055 MTORC1, MTORC2 PI3K/MTOR signaling 25262965 870 266
17 1032 Afatinib BIBW2992, Tovok, Gilotrif ERBB2, EGFR EGFR signaling 10184653 881 266
18 1377 Afatinib BIBW2992, Tovok, Gilotrif ERBB2, EGFR EGFR signaling 10184653 944 266
19 281 Alectinib CH5424802, CH 542802, Alecensa ALK RTK signaling 49806720 974 266
20 293 Amuvatinib MP470, MP 470, MP-470 KIT, PDGFRA, FLT3 Other, kinases 11282283 971 266
21 205 Avagacestat BMS-708163, BMS 708163 Amyloid beta20, Amyloid beta40 Other 46883536 977 266
22 1072 Avagacestat BMS-708163, BMS 708163 Amyloid beta20, Amyloid beta40 Other 46883536 957 266
23 1021 Axitinib AG-13736, Inlyta PDGFR, KIT, VEGFR RTK signaling 6450551 877 266
24 178 BAY-61-3606 Syk Inhibitor, BAY-613606 SYK Other, kinases 10200390 925 266
25 60 BI-2536 PLK1, PLK2, PLK3 Cell cycle 11364421 424 266
26 279 BIX02189 BIX 02189 MEK5, ERK5 ERK MAPK signaling 46931012 975 266
27 203 BMS-345541 BMS345541, IKK Inhibitor 3 IKK1, IKK2 Other, kinases 9813758 980 266
28 63 BMS-509744 KIN001-127, ITK inhibitor ITK Other 20635522 426 266
29 62 BMS-536924 BMS 536924 IGF1R, IR IGFR signaling 10390396 425 266
30 1091 BMS-536924 BMS 536924 IGF1R, IR Unclassified 10390396 956 266
31 184 BMS-754807 BMS754807, BMS 754807 IGF1R, IR IGFR signaling 24785538 924 266
32 222 BX-912 PDK1 (PDPK1) PI3K/MTOR signaling 11754511 978 266
33 1037 BX795 BX-795 TBK1, PDK1 (PDPK1), IKK, AURKB, AURKC Other 10077147 878 266
34 274 Belinostat PXD101, PXD-101 HDAC1 Chromatin histone acetylation 6918638 948 266
35 186 Bexarotene LG-100069, Targretin, Targret, Targrexin, Targretyn, Bexarotenum Retinioic X receptor (RXR) agonist Other 82146 917 266
36 150 Bicalutamide ICI-176334, Casodex, Cosudex, ICI 176334 AR Hormone-related 2375 927 266
37 1502 Bicalutamide ICI-176334, Casodex, Cosudex, ICI 176334 AR Hormone-related 2375 903 266
38 190 Bleomycin dsDNA break induction DNA replication several 920 266
39 1378 Bleomycin dsDNA break induction DNA replication 5460769 965 266
40 104 Bortezomib PS-341, LDP-341, Velcade Proteasome Protein stability and degradation 387447 426 266
41 1019 Bosutinib SKI-606, Bosulif SRC, ABL, TEC Other, kinases 5328940 883 266
42 197 Bryostatin 1 Bryostatin PKC Other, kinases 5280757 923 266
43 276 CAY10603 HDAC1, HDAC6 Chromatin histone acetylation 24951314 968 266
44 1170 CCT-018159 CCT018159, CCT 018159 HSP90 Protein stability and degradation 5327091 929 266
45 1067 CCT007093 PPM1D Other 2314623 952 266
46 54 CGP-082996 CINK4, KIN001-021 CDK4 Cell cycle 24825971 425 266
47 53 CGP-60474 KIN001-019, CGP60474, CGP 60474 CDK1,CDK2,CDK5,CDK7,CDK9, PKC Cell cycle 644215 425 266
48 154 CHIR-99021 CT 99021, CHIR99021, CHIR 99021 GSK3A, GSK3B WNT signaling 9956119 935 266
49 1241 CHIR-99021 CT 99021, CHIR99021, CHIR 99021 GSK3A, GSK3B WNT signaling 9956119 944 266
50 1015 CI-1040 CI 1040, PD-18435, PD-184352, 212631-79-3 MEK1, MEK2 ERK MAPK signaling 6918454 871 266
51 64 CMK KIN001-128 RSK2 ERK MAPK signaling 16663089 425 266
52 152 CP466722 CP-466722, CP 466722, 1080622-86-1 ATM Genome integrity 44551660 980 266
53 255 CP724714 CP-724714 ERBB2 EGFR signaling 9874913 977 266
54 273 CUDC-101 CUDC 101 HDAC1-10, EGFR, ERBB2 Other 24756910 957 266
55 300 CX-5461 CX5461, CX 5461 RNA Polymerase 1 Other 25257557 971 266
56 249 Cabozantinib BMS-907351, XL-184, Cometriq VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, TIE2,AXL Other, kinases 25102847 975 266
57 1114 Cetuximab Erbitux, IMC-C225, C225, IMC-225, L01XC06 EGFR EGFR signaling 85668777 899 266
58 1005 Cisplatin cis-Diammineplatinum(II) dichloride, Platinol, CIS-DDP DNA crosslinker DNA replication 84691 882 266
59 37 Crizotinib Xalkori, PF2341066, PF-2341066, PF 2341066 MET, ALK, ROS1 RTK signaling 11626560 433 266
60 17 Cyclopamine SMO Other several 421 266
61 1006 Cytarabine Ara-Cytidine, Arabinosyl Cytosine, U-19920 Antimetabolite DNA replication 6253 878 266
62 165 DMOG Dimethyloxalylglcine HIF-PH Metabolism 560326 934 266
63 1373 Dabrafenib GSK2118436, Tafinlar BRAF ERK MAPK signaling 44462760 899 266
64 200 Dacinostat NVP-LAQ824, LAQ824 HDAC1 Chromatin histone acetylation 6445533 929 266
65 1057 Dactolisib NVP-BEZ235, BEZ235 PI3K (Class 1), MTORC1, MTORC2 PI3K/MTOR signaling 11977753 871 266
66 1248 Daporinad APO866, FK866, FK866 NAMPT Metabolism 6914657 930 266
67 51 Dasatinib BMS-354825-03, BMS-354825, Sprycel ABL, SRC, Ephrins, PDGFR, KIT Other 3062316 422 266
68 1007 Docetaxel RP-56976, Taxotere Microtubule stabiliser Mitosis 148124 882 266
69 1042 Doramapimod BIRB-796, BIRB 796 p38, JNK2 JNK and p38 signaling 156422 867 266
70 133 Doxorubicin Doxil, Rubex, Adriamycin, Adriablastin, Doxorubicine Anthracycline DNA replication 31703 928 266
71 1069 EHT-1864 EHT 1864 RAC1, RAC2, RAC3 Cytoskeleton 9938202 955 266
72 1031 Elesclomol STA-4783 HSP90 Protein stability and degradation 300471 881 266
73 172 Embelin Emberine, Embelic acid XIAP Apoptosis regulation 3218 929 266
74 88 Entinostat MS-275 HDAC1, HDAC3 Chromatin histone acetylation 4261 427 266
75 229 Enzastaurin LY317615 PKCB Other, kinases 176167 978 266
76 201 Epothilone B Patupilone, EpoB, EPO906, GNF-PF-193 Microtubule stabiliser Mitosis 448013 928 266
77 1 Erlotinib Tarceva, RG-1415, CP-358774, OSI-774, Ro-508231, R-1415 EGFR EGFR signaling 176870 392 266
78 134 Etoposide Etopophos, Vepesid, Eposin, VP-16 TOP2 DNA replication 36462 936 266
79 173 FH535 PPARgamma, PPARdelta WNT signaling 3463933 926 266
80 231 FMK KIN001-242 RSK Other, kinases none 836 266
81 263 FR-180204 FR 180204, FR180204, ERK Inhibitor II ERK1, ERK2 ERK MAPK signaling 11493598 975 266
82 166 FTI-277 Farnesyl-transferase (FNTA) Other 3005532 937 266
83 306 Fedratinib TG101348, TG-101348, SAR302503, SAR-302503 JAK2 Other, kinases 16722836 976 266
84 308 Foretinib GSK1363089, XL-880, EXEL-2880, GSK089 MET, KDR, TIE2, VEGFR3/FLT4, RON, PDGFR, FGFR1, EGFR RTK signaling 42642645 972 266
85 52 GNF-2 KIN001-013 BCR-ABL ABL signaling 5311510 423 266
86 226 GSK1070916 GSK-1070916 AURKA, AURKC Mitosis 46885626 950 266
87 202 GSK1904529A GSK-1904529A, GSK 1904529A IGF1R, IR IGFR signaling 25124816 928 266
88 127 GSK269962A GSK 269962A ROCK1, ROCK2 Cytoskeleton 16095342 429 266
89 1192 GSK269962A GSK 269962A ROCK1, ROCK2 Cytoskeleton 16095342 958 266
90 91 GSK319347A KIN001-135, IKK-3 inhibitor IKK Other 11626927 428 266
91 230 GSK429286A ROCK1, ROCK2 Cytoskeleton 11373846 980 266
92 177 GSK650394 GSK-650394, GSK 650394 SGK2, SGK3 Other 25022668 920 266
93 326 GSK690693 GSK 690693, GSK-690693 AKT1, AKT2, AKT3 PI3K/MTOR signaling 16725726 975 266
94 193 GW-2580 GX2580, CFMS receptor tyrosine kinase inhibitor CSF1R RTK signaling 11617559 977 266
95 1023 GW441756 GW 441756 NTRK1 RTK signaling 9943465 879 266
96 87 GW843682X GW843682X (AN-13) PLK1 Cell cycle 9826308 426 266
97 1010 Gefitinib ZD-1839, Iressa EGFR EGFR signaling 123631 878 266
98 135 Gemcitabine Gemzar, LY-188011 Pyrimidine antimetabolite DNA replication 60750 923 266
99 225 Genentech Cpd 10 AURKA, AURKB Mitosis none 980 266
100 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) Other none 512 266