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CML_ec50_fit_table.csv
| # | cancer | drug | gene | lm_result_aic | gam_result_aic | rlm_result_aic | lm_result_r2 | gam_result_r2 | rlm_result_mse | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | CML | bosutinib | ABL1 | -417.814338951822 | -418.628309092696 | -417.721132140492 | 0.0022580579580419 | 0.00420153691558012 | 0.141886398031769 |
| 2 | 2 | CML | bosutinib | BCR | -165.0266638543 | -165.642110224251 | -164.020628217143 | 0.00255562849620719 | 0.0031211966588629 | 0.136623161166245 |
| 3 | 3 | CML | bosutinib | CCDC6 | -233.629907571275 | -233.629907543019 | -232.685352284003 | 7.81035152957369e-05 | -0.00215885812723116 | 0.115266175845057 |
| 4 | 4 | CML | bosutinib | CSF3R | -483.544278966262 | -483.544278940313 | -483.194641206888 | 0.00885288006788433 | 0.00663554869027705 | 0.104635797156169 |
| 5 | 5 | CML | bosutinib | ETNK1 | 34.9303244345169 | 34.9303244487345 | 44.6358650714368 | 0.000219498063022115 | -0.00201714736856196 | 0.136314583837903 |
| 6 | 6 | CML | bosutinib | GATA2 | -392.926919524569 | -392.926919480964 | -391.384755233303 | 0.00121149367153235 | -0.00102293246748131 | 0.11890748553921 |
| 7 | 7 | CML | bosutinib | HOXA11 | -104.818828250336 | -107.963830614959 | -104.291625939721 | 0.000175707191130836 | 0.0132535426478999 | 0.197063348675475 |
| 8 | 8 | CML | bosutinib | JAK2 | 66.4535728425001 | 66.6349169821409 | 67.0597028865951 | 0.000120705998661217 | 0.00335943091641344 | 0.214227706978041 |
| 9 | 9 | CML | bosutinib | MECOM | -112.981572403496 | -110.75260926574 | -111.016769456803 | 0.00634304027203267 | 0.0144008884482 | 0.16743243074376 |
| 10 | 10 | CML | bosutinib | MSI2 | -307.943640863597 | -307.943640836598 | -306.433378095239 | 0.00240060317382143 | 0.000168837235834718 | 0.128200909040305 |
| 11 | 11 | CML | bosutinib | PCM1 | -117.540726553255 | -119.304395227856 | -116.344154450793 | 0.009607121598341 | 0.0145879953436906 | 0.196119877554436 |
| 12 | 12 | CML | bosutinib | PDGFRB | -479.845176234891 | -479.845176203653 | -478.536139363952 | 0.000382231055493977 | -0.00185405033094721 | 0.118777077656079 |
| 13 | 13 | CML | bosutinib | RPL22 | -491.333326156881 | -491.33332613416 | -490.646071529319 | 0.000347020963234406 | -0.00188933918253409 | 0.119598571401091 |
| 14 | 14 | CML | bosutinib | SETBP1 | -173.571683835232 | -175.510796099323 | -173.544184836338 | 0.000746325224751933 | 0.0162221211351223 | 0.206823100742877 |
| 15 | 15 | CML | hydroxyurea | ABL1 | -425.349066089172 | -429.405612115432 | -425.212882563954 | 0.000766932332614963 | 0.0129246730252337 | 0.140474250827204 |
| 16 | 16 | CML | hydroxyurea | BCR | -196.752689124312 | -197.854833515925 | -195.988722412355 | 0.00200149079475595 | 0.00376284125371995 | 0.137114572539011 |
| 17 | 17 | CML | hydroxyurea | CCDC6 | -323.771484927097 | -323.771484885695 | -323.285270846966 | 0.00143034648898211 | -0.000783776901825517 | 0.11589734336869 |
| 18 | 18 | CML | hydroxyurea | CSF3R | -487.311805241585 | -487.436695738642 | -487.192738213144 | 0.00420488410119637 | 0.00292984468183488 | 0.101292645317935 |
| 19 | 19 | CML | hydroxyurea | ETNK1 | 45.5912418911365 | 46.3287358341229 | 55.645480974612 | 0.0137947884574157 | 0.0152950251974495 | 0.133330857097059 |
| 20 | 20 | CML | hydroxyurea | GATA2 | -407.947164324862 | -407.947164296026 | -406.415155214199 | 0.00564794441815895 | 0.00344317293031005 | 0.119758021690825 |
| 21 | 21 | CML | hydroxyurea | HOXA11 | -163.247782021734 | -163.321020259545 | -163.159297797407 | 0.00026293290150628 | -0.00127489589551222 | 0.201421880435621 |
| 22 | 22 | CML | hydroxyurea | JAK2 | 50.0829065107369 | 49.8304323852036 | 50.5499727385548 | 0.00335010743294108 | 0.00257889747312301 | 0.21615402181859 |
| 23 | 23 | CML | hydroxyurea | MECOM | -120.336591784314 | -120.352362029679 | -118.087903490041 | 0.00558705175586131 | 0.00373395453005532 | 0.162899694257076 |
| 24 | 24 | CML | hydroxyurea | MSI2 | -318.607625961794 | -318.701549373322 | -317.114618617742 | 0.00015989214869104 | -0.00122871984355455 | 0.125288622679668 |
| 25 | 25 | CML | hydroxyurea | PCM1 | -116.402296669382 | -124.478769012026 | -116.035000412314 | 0.00712840692787307 | 0.030303486716707 | 0.203479349498268 |
| 26 | 26 | CML | hydroxyurea | PDGFRB | -476.717928838648 | -476.717928787499 | -475.450567019349 | 0.000752653841384497 | -0.00146297225515268 | 0.120980985216381 |
| 27 | 27 | CML | hydroxyurea | RPL22 | -487.615285277601 | -487.615285250975 | -486.908900156958 | 0.000258494735074954 | -0.00195822703240034 | 0.118169596009805 |
| 28 | 28 | CML | hydroxyurea | SETBP1 | -183.784238029194 | -183.784238010951 | -183.71281057598 | 0.000168218193929962 | -0.00204870372762067 | 0.206646802182628 |
| 29 | 29 | CML | busulfan | ABL1 | -408.261139601466 | -408.973359826713 | -408.167208029273 | 0.000244056217630511 | 0.00731466044320506 | 0.138580002720035 |
| 30 | 30 | CML | busulfan | BCR | -114.352613234113 | -109.879831968078 | -112.198541998598 | 9.87567562750218e-05 | 0.00466140107932889 | 0.141375531950121 |
| 31 | 31 | CML | busulfan | CCDC6 | -262.942373863408 | -262.942373830464 | -261.998458288142 | 0.00103808455867002 | -0.00144689523575003 | 0.117735611687555 |
| 32 | 32 | CML | busulfan | CSF3R | -422.93203094416 | -424.420535750504 | -422.686124351578 | 0.00012608436852632 | 0.0197915162697215 | 0.113128612942464 |
| 33 | 33 | CML | busulfan | ETNK1 | 56.4088255464603 | 56.4088255590178 | 64.4686252771862 | 0.000398978260150316 | -0.00208759145480175 | 0.138569708231981 |
| 34 | 34 | CML | busulfan | GATA2 | -344.961054308458 | -344.961054289226 | -343.571244185055 | 0.0010706029959325 | -0.00141429601864629 | 0.112832496331766 |
| 35 | 35 | CML | busulfan | HOXA11 | -85.9187948118938 | -85.9187948019371 | -85.3689139355187 | 0.000809949181292755 | -0.0016755982015153 | 0.200381461202556 |
| 36 | 36 | CML | busulfan | JAK2 | 60.145512077582 | 60.14551208983 | 60.6045906986582 | 0.00045970320131093 | -0.00202671545646305 | 0.225007334990195 |
| 37 | 37 | CML | busulfan | MECOM | -80.9840614723144 | -80.9840614616858 | -78.3972131821862 | 0.000497432039482078 | -0.00198889276725422 | 0.164850213702376 |
| 38 | 38 | CML | busulfan | MSI2 | -273.424372486339 | -273.424372451189 | -272.168483460332 | 0.000441773413489571 | -0.00204468987359374 | 0.125741944879415 |
| 39 | 39 | CML | busulfan | PCM1 | -165.471664218259 | -166.181716343793 | -165.040437585219 | 4.74041118290818e-07 | 0.0147912841779257 | 0.198427485911012 |
| 40 | 40 | CML | busulfan | PDGFRB | -453.110636903432 | -453.121759827762 | -451.508396797782 | 0.00236042754325699 | 0.000190242423479203 | 0.116510613439542 |
| 41 | 41 | CML | busulfan | RPL22 | -455.936443414036 | -456.895717642066 | -454.538206158175 | 0.00133312575005092 | 0.0119170624533728 | 0.117127815311194 |
| 42 | 42 | CML | busulfan | SETBP1 | -152.574002000537 | -152.574001986514 | -152.544317475585 | 0.000929249133569656 | -0.00155600149332469 | 0.213091305775612 |
| 43 | 43 | CML | dasatinib | ABL1 | -768.573662978597 | -763.736745915304 | -768.368521817509 | 0.000376912613912644 | 0.00101953112503628 | 0.14159188701781 |
| 44 | 44 | CML | dasatinib | BCR | -226.426333729833 | -226.618555537623 | -224.865268645755 | 0.000567722535845557 | 2.99233667688803e-05 | 0.13801545142838 |
| 45 | 45 | CML | dasatinib | CCDC6 | -604.2817452228 | -603.21424013777 | -603.07227640316 | 0.00221209498378854 | 0.00522129803471949 | 0.115533873338459 |
| 46 | 46 | CML | dasatinib | CSF3R | -881.343538202976 | -882.03948992686 | -881.077328922272 | 0.000235318845937528 | 0.000609652207877343 | 0.105706988900393 |
| 47 | 47 | CML | dasatinib | ETNK1 | 111.464828812872 | 111.464828829621 | 129.571998843247 | 0.000678285463254572 | -0.000546373502903874 | 0.12955607777515 |
| 48 | 48 | CML | dasatinib | GATA2 | -740.431455387036 | -735.398514013272 | -737.888324335307 | 5.87117654758913e-05 | 0.000762292251243024 | 0.120928044449684 |
| 49 | 49 | CML | dasatinib | HOXA11 | -147.348999044095 | -147.543100413952 | -146.082368224827 | 1.09894113639444e-06 | -0.000486607305522302 | 0.196899955176862 |
| 50 | 50 | CML | dasatinib | JAK2 | 103.257242959948 | 101.46722256755 | 104.401059664858 | 2.03945496435309e-05 | 0.00365661253485383 | 0.218343757586385 |
| 51 | 51 | CML | dasatinib | MECOM | -226.905789950031 | -231.409436444092 | -223.103830334718 | 0.000716486138670025 | 0.00787784177146589 | 0.163599732155309 |
| 52 | 52 | CML | dasatinib | MSI2 | -554.499261383438 | -554.499261349055 | -551.150314198652 | 0.000140559580601734 | -0.00108475838179456 | 0.126560674272177 |
| 53 | 53 | CML | dasatinib | PCM1 | -201.276986398774 | -199.676370311439 | -200.661525975188 | 0.000760489233583215 | 0.00098008354874457 | 0.197633750737855 |
| 54 | 54 | CML | dasatinib | PDGFRB | -874.017658613192 | -875.744886532287 | -872.079088472689 | 0.000280929015545005 | 0.00511574194390796 | 0.121354486169514 |
| 55 | 55 | CML | dasatinib | RPL22 | -875.404153164558 | -879.119791543457 | -874.147946078077 | 0.000291694618754887 | 0.0074608666180136 | 0.118685544190551 |
| 56 | 56 | CML | dasatinib | SETBP1 | -322.628490064639 | -324.901498437902 | -322.605446026642 | 0.00268232668540674 | 0.00531364005156965 | 0.206688087615685 |
| 57 | 57 | CML | decitabine | ABL1 | -753.71623103081 | -754.404864002233 | -753.386715587572 | 0.000216641236153947 | 0.000523367412085807 | 0.140218628315485 |
| 58 | 58 | CML | decitabine | BCR | -262.883952329248 | -264.595518831823 | -261.723743081248 | 0.00193629683491418 | 0.00383818072204156 | 0.133905617085099 |
| 59 | 59 | CML | decitabine | CCDC6 | -463.899983112713 | -463.899983074387 | -462.588830834419 | 0.0046927311832809 | 0.0034391955804649 | 0.117969633692728 |
| 60 | 60 | CML | decitabine | CSF3R | -870.740358778683 | -870.830211911599 | -870.458767389785 | 0.00116472186506964 | 0.00236197334239108 | 0.107205750097223 |
| 61 | 61 | CML | decitabine | ETNK1 | 75.0685868606011 | 74.9553456901069 | 91.0961292863329 | 0.00496756333957971 | 0.00423095813313557 | 0.131940781700075 |
| 62 | 62 | CML | decitabine | GATA2 | -706.612761296691 | -704.043792875184 | -704.535721325453 | 0.00057598939591499 | 0.00524517387257117 | 0.120493170859367 |
| 63 | 63 | CML | decitabine | HOXA11 | -151.27855085448 | -151.278550822971 | -150.357502387648 | 8.84483412329272e-05 | -0.00117088609662863 | 0.195890288856639 |
| 64 | 64 | CML | decitabine | JAK2 | 86.9055870795326 | 84.7505435086205 | 87.5769740582451 | 0.000251938430505619 | 0.00421104211944523 | 0.218840299444675 |
| 65 | 65 | CML | decitabine | MECOM | -205.557693210759 | -201.055865097073 | -202.18795611433 | 0.000213922763926857 | 0.00187518931954889 | 0.164468517555127 |
| 66 | 66 | CML | decitabine | MSI2 | -527.676148215325 | -527.80082939665 | -524.698716143489 | 6.6001817618253e-05 | -0.00056269680299792 | 0.128701899758586 |
| 67 | 67 | CML | decitabine | PCM1 | -208.638387239687 | -208.638387210714 | -208.11212394292 | 0.00409758167958913 | 0.00284329650166082 | 0.197479679314396 |
| 68 | 68 | CML | decitabine | PDGFRB | -856.448072391873 | -856.448072352372 | -854.44245599271 | 0.007328992149758 | 0.00607877676611934 | 0.117966907840209 |
| 69 | 69 | CML | decitabine | RPL22 | -857.07969846507 | -857.079698382291 | -855.908345234198 | 0.0100197129123306 | 0.00877288631092787 | 0.116939395353018 |
| 70 | 70 | CML | decitabine | SETBP1 | -297.989071630145 | -297.989071602073 | -297.970160486331 | 0.000204174648638479 | -0.00105501406282915 | 0.208654838639339 |
| 71 | 71 | CML | cyclophosphamide | ABL1 | -310.23786004961 | -310.237860030639 | -309.948242548397 | 0.00142178581462923 | -0.00166024572921186 | 0.142210179151725 |
| 72 | 72 | CML | cyclophosphamide | BCR | -95.2605663309605 | -95.7098778043407 | -94.4277049859688 | 0.000694768752400783 | 0.000815027957686842 | 0.14357138686891 |
| 73 | 73 | CML | cyclophosphamide | CCDC6 | -267.882246797206 | -267.882246770292 | -267.822034433237 | 3.84239316284546e-05 | -0.0030478772702387 | 0.119988675226833 |
| 74 | 74 | CML | cyclophosphamide | CSF3R | -342.087229605746 | -342.087229583412 | -342.018234247484 | 0.0217188028953947 | 0.0186994165056847 | 0.105785831974183 |
| 75 | 75 | CML | cyclophosphamide | ETNK1 | 46.7049334180315 | 44.8470995898281 | 53.954265608686 | 0.000901218227649381 | 0.0093927753624431 | 0.143926417133375 |
| 76 | 76 | CML | cyclophosphamide | GATA2 | -262.385934779207 | -262.385934760816 | -261.283653365677 | 0.00049886218212878 | -0.00258601778714085 | 0.123050396061844 |
| 77 | 77 | CML | cyclophosphamide | HOXA11 | -115.348668449378 | -115.348668428361 | -115.197314464791 | 6.43655025141722e-05 | -0.00302185561663881 | 0.201744106027837 |
| 78 | 78 | CML | cyclophosphamide | JAK2 | 57.1336862201539 | 57.1336862332223 | 57.4852917644241 | 0.000355411980761546 | -0.00272991082547591 | 0.210020290156405 |
| 79 | 79 | CML | cyclophosphamide | MECOM | -68.7341289239805 | -69.902530164522 | -67.58097688452 | 0.00395565742297057 | 0.00780900014744834 | 0.163585438330764 |
| 80 | 80 | CML | cyclophosphamide | MSI2 | -202.270307080879 | -212.12381438627 | -200.715165689695 | 0.0163918169313022 | 0.0583609577541714 | 0.119780901898307 |
| 81 | 81 | CML | cyclophosphamide | PCM1 | -141.058351126849 | -141.058351112023 | -140.931144207448 | 0.00302977484157344 | -4.72937618127833e-05 | 0.200413707098214 |
| 82 | 82 | CML | cyclophosphamide | PDGFRB | -361.360834488739 | -361.477780978494 | -360.336721833267 | 0.000703276376992423 | -0.000839299625017276 | 0.123637178959021 |
| 83 | 83 | CML | cyclophosphamide | RPL22 | -367.168131095616 | -367.36862676196 | -366.261203631277 | 0.000375501825708899 | -0.000878004398592314 | 0.118901810109155 |
| 84 | 84 | CML | cyclophosphamide | SETBP1 | -148.494347214719 | -152.716895742511 | -148.407888404989 | 0.000857294463751074 | 0.0137535608553088 | 0.206604404384908 |
| 85 | 85 | CML | homoharringtonine | ABL1 | -844.298243601199 | -844.298243562131 | -844.059025137564 | 1.26430059213133e-05 | -0.0011122021835428 | 0.139542498139043 |
| 86 | 86 | CML | homoharringtonine | BCR | -288.108399779317 | -285.944307241193 | -286.069119742561 | 0.00487125072251963 | 0.00853532473868845 | 0.139348461677127 |
| 87 | 87 | CML | homoharringtonine | CCDC6 | -585.899060241317 | -585.938784375152 | -584.968661134625 | 0.00385901490162121 | 0.00302546777969726 | 0.116587711017652 |
| 88 | 88 | CML | homoharringtonine | CSF3R | -960.21981903739 | -960.219818982941 | -960.080581984148 | 0.00279542803657539 | 0.00167371340584288 | 0.108818653673892 |
| 89 | 89 | CML | homoharringtonine | ETNK1 | 83.8640093097693 | 83.8640093345156 | 102.16465488693 | 0.0019413076884079 | 0.000818631983555584 | 0.132691720995864 |
| 90 | 90 | CML | homoharringtonine | GATA2 | -776.987624312605 | -775.079380738042 | -774.180236677445 | 0.000228010586474273 | 0.00228953584736691 | 0.123217097030126 |
| 91 | 91 | CML | homoharringtonine | HOXA11 | -219.619109519597 | -221.574622952282 | -218.851643242139 | 0.000245136823891151 | 0.00393026854989031 | 0.197003307430874 |
| 92 | 92 | CML | homoharringtonine | JAK2 | 120.326094204629 | 101.052732696502 | 121.611201540794 | 0.0158558606256743 | 0.0408072653419658 | 0.21762961924313 |
| 93 | 93 | CML | homoharringtonine | MECOM | -213.606391484327 | -213.863511587142 | -209.684087100041 | 0.00145050498148532 | 0.00250893309337141 | 0.166719406624064 |
| 94 | 94 | CML | homoharringtonine | MSI2 | -635.44264232941 | -635.442642256417 | -632.353779936366 | 0.000170227249094572 | -0.000954440700896342 | 0.123893502037252 |
| 95 | 95 | CML | homoharringtonine | PCM1 | -235.438963824335 | -241.729638263004 | -234.768428210713 | 0.000139529170303625 | 0.0114190928761111 | 0.196782117413256 |
| 96 | 96 | CML | homoharringtonine | PDGFRB | -974.254954799771 | -974.254954726638 | -971.940469510489 | 0.000402725475112511 | -0.00072168091964353 | 0.116314847112569 |
| 97 | 97 | CML | homoharringtonine | RPL22 | -991.474362288491 | -991.474362176318 | -990.208692401509 | 0.0019943750094334 | 0.000871758947688428 | 0.115510328181644 |
| 98 | 98 | CML | homoharringtonine | SETBP1 | -378.390077566797 | -378.390077521508 | -378.374763917803 | 1.00253599274943e-05 | -0.00111482277627251 | 0.206531311103652 |
| 99 | 99 | CML | ponatinib | ABL1 | -851.477308182366 | -851.47730808925 | -851.260881007974 | 0.000839907759339833 | -0.000267808565416638 | 0.138489625101482 |
| 100 | 100 | CML | ponatinib | BCR | -296.026610473947 | -296.026610434095 | -294.043319619411 | 0.000439344572630136 | -0.000668815693851688 | 0.13565291691529 |