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SKCM_ec50_fit_table.csv
| # | cancer | drug | gene | lm_result_aic | gam_result_aic | rlm_result_aic | lm_result_r2 | gam_result_r2 | rlm_result_mse | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | SKCM | dabrafenib | ATF1 | -1054.72950803015 | -1054.72950797466 | -1054.70607686964 | 0.00171126180942621 | 0.000519986435691955 | 0.0879443208781875 |
| 2 | 2 | SKCM | dabrafenib | B2M | -760.500704709431 | -760.500704662143 | -758.873980690389 | 0.000314239728334541 | -0.000878702731741177 | 0.102695957892225 |
| 3 | 3 | SKCM | dabrafenib | BAP1 | -502.405622879746 | -502.405622834593 | -497.76527106457 | 7.84930443261288e-06 | -0.00118545876809906 | 0.156086293483278 |
| 4 | 4 | SKCM | dabrafenib | BRAF | -515.752140417583 | -529.664353749889 | -513.585401028012 | 0.00172179164682698 | 0.0215147476773933 | 0.136430951583108 |
| 5 | 5 | SKCM | dabrafenib | CDKN2A | 980.054953479596 | 980.02581618238 | 980.056380960239 | 0.00109331177089179 | 0.000121056202109449 | 0.645107855480057 |
| 6 | 6 | SKCM | dabrafenib | CUX1 | -132.71319777214 | -138.503650073783 | -132.194044947059 | 5.40899022118741e-05 | 0.0104455665633872 | 0.163271184238839 |
| 7 | 7 | SKCM | dabrafenib | ERBB4 | -1321.96256338886 | -1320.93044585813 | -1315.77839654551 | 0.0198311864964621 | 0.0222348228820712 | 0.0747269056585635 |
| 8 | 8 | SKCM | dabrafenib | FAT4 | -1033.88475092051 | -1033.88475084381 | -1033.82409951408 | 0.00235619400486537 | 0.00116568826352992 | 0.145291405162246 |
| 9 | 9 | SKCM | dabrafenib | GNA11 | -902.536683546105 | -903.496471389383 | -902.225547140389 | 0.00473298877290161 | 0.00545365360213312 | 0.132179691234706 |
| 10 | 10 | SKCM | dabrafenib | GNAQ | -634.640671343795 | -634.640671300246 | -633.736218512793 | 0.000113560488829972 | -0.00107962143840123 | 0.140063664779134 |
| 11 | 11 | SKCM | dabrafenib | GRIN2A | -853.329459191631 | -867.848315282671 | -851.694850907311 | 0.00122557556618329 | 0.0218840442911781 | 0.11383239940322 |
| 12 | 12 | SKCM | dabrafenib | IRS4 | -280.15968865615 | -280.159688619555 | -279.011984588382 | 0.000117691806543583 | -0.00107548518882505 | 0.234992449346247 |
| 13 | 13 | SKCM | dabrafenib | KIT | -235.798920709441 | -235.79892068454 | -231.714589865398 | 0.000121732284270645 | -0.00107143988631786 | 0.139160757418007 |
| 14 | 14 | SKCM | dabrafenib | MAP2K1 | -1008.32719938453 | -1008.29471021319 | -1005.02573957061 | 0.000933711255431171 | -0.000270211283372124 | 0.101905037817465 |
| 15 | 15 | SKCM | dabrafenib | MAP2K2 | -960.1016211154 | -961.316814147772 | -959.366969302461 | 0.00341803666046662 | 0.00448734844005816 | 0.129434756661008 |
| 16 | 16 | SKCM | dabrafenib | MITF | -269.219826570222 | -285.406962582961 | -266.698474537528 | 0.00291551425135214 | 0.0222161964723526 | 0.163654828922314 |
| 17 | 17 | SKCM | dabrafenib | NFKBIE | -197.853133037871 | -197.853133013667 | -197.547992068906 | 0.000330020244462219 | -0.000862903371756651 | 0.112999026265519 |
| 18 | 18 | SKCM | dabrafenib | NRAS | 61.1992600691325 | 63.0065983708215 | 66.224614060848 | 0.00034015973385396 | 0.00462958081164266 | 0.126371684498967 |
| 19 | 19 | SKCM | dabrafenib | PPP6C | -784.784851586432 | -784.784233214457 | -783.21368220786 | 0.00709800279039092 | 0.00591290750883333 | 0.137114037928415 |
| 20 | 20 | SKCM | dabrafenib | PREX2 | -389.714242098997 | -391.037058259213 | -389.002593079116 | 0.00554870611789719 | 0.00685408975295199 | 0.152799717543797 |
| 21 | 21 | SKCM | dabrafenib | PTPRT | -152.869806742448 | -154.697983371667 | -150.818053029068 | 0.0016762462895588 | 0.00413274000261887 | 0.205151164021897 |
| 22 | 22 | SKCM | dabrafenib | RAC1 | -118.286876472464 | -118.872916795681 | -115.64503398005 | 0.00134964277973075 | 0.00312221146403013 | 0.212023415447447 |
| 23 | 23 | SKCM | dabrafenib | SALL4 | -67.9488680088272 | -67.9488679894469 | -63.6639433572093 | 0.00032159114908873 | -0.000871342503221184 | 0.221286380733811 |
| 24 | 24 | SKCM | dabrafenib | SFRP4 | -252.516479292385 | -252.516479260185 | -251.663283533927 | 8.17055938350936e-05 | -0.00111151433400414 | 0.199908690893874 |
| 25 | 25 | SKCM | dabrafenib | STAG2 | -284.385957484542 | -284.385957461482 | -283.373798840416 | 0.000376116102258884 | -0.000816752489544159 | 0.238473875883327 |
| 26 | 26 | SKCM | dabrafenib | TERT | 180.725762575854 | 179.089288909126 | 189.046538982574 | 1.7367923337905e-05 | 0.001687030532321 | 0.23509419838373 |
| 27 | 27 | SKCM | dabrafenib | TRRAP | 160.849679633371 | 158.15599514958 | 165.199675975946 | 3.25989948883112e-08 | 0.0092435891126802 | 0.175766985234942 |
| 28 | 28 | SKCM | vemurafenib | ATF1 | -991.756053798112 | -992.620652360543 | -991.616230530504 | 0.000798478002591494 | 0.00532378468556993 | 0.0925166223680799 |
| 29 | 29 | SKCM | vemurafenib | B2M | -725.865881184412 | -725.865881123866 | -725.617649497904 | 0.00218750139686959 | 0.000894998128389668 | 0.102645968352493 |
| 30 | 30 | SKCM | vemurafenib | BAP1 | -458.146519687325 | -458.358782332988 | -454.00771249865 | 0.000729069228988114 | 0.00180728121352014 | 0.15728412595606 |
| 31 | 31 | SKCM | vemurafenib | BRAF | -512.491361644269 | -513.649876852931 | -511.374127414045 | 0.00092083162805639 | 0.00971935261306434 | 0.138222841230498 |
| 32 | 32 | SKCM | vemurafenib | CDKN2A | 890.104758279575 | 890.104758285562 | 890.105462763498 | 0.000318264506423727 | -0.000976659552309966 | 0.635694651380324 |
| 33 | 33 | SKCM | vemurafenib | CUX1 | -111.861766485883 | -112.003096483808 | -110.953727016115 | 0.000133874706418451 | 0.00137422491500538 | 0.165667650464968 |
| 34 | 34 | SKCM | vemurafenib | ERBB4 | -1184.08955201301 | -1184.08955195105 | -1178.9797605754 | 4.75975491766498e-05 | -0.001247677617086 | 0.0743396504856897 |
| 35 | 35 | SKCM | vemurafenib | FAT4 | -953.855627903129 | -953.855627834256 | -953.382758327515 | 0.00346151084321891 | 0.00217065784317061 | 0.144387551414423 |
| 36 | 36 | SKCM | vemurafenib | GNA11 | -854.549387155161 | -852.521085596559 | -853.750997879976 | 0.00206804976505431 | 0.00510476129663007 | 0.131373004058157 |
| 37 | 37 | SKCM | vemurafenib | GNAQ | -595.296388287425 | -599.823742976825 | -595.07596803897 | 0.00170492564656915 | 0.0098379745525139 | 0.140877333391258 |
| 38 | 38 | SKCM | vemurafenib | GRIN2A | -751.441267978185 | -751.441267907869 | -750.546911576131 | 0.00114393846036396 | -0.000149916163037389 | 0.118269014731338 |
| 39 | 39 | SKCM | vemurafenib | IRS4 | -276.10102081441 | -276.101020764878 | -275.024037335452 | 0.00888569314673648 | 0.00760186629808124 | 0.225618823929926 |
| 40 | 40 | SKCM | vemurafenib | KIT | -201.462255832298 | -201.590763918393 | -196.19252259342 | 0.007023543299387 | 0.00628468018978212 | 0.136927967152086 |
| 41 | 41 | SKCM | vemurafenib | MAP2K1 | -952.13674199067 | -952.136741880968 | -949.088828023674 | 0.000309195924836251 | -0.000985740396755252 | 0.100207180584223 |
| 42 | 42 | SKCM | vemurafenib | MAP2K2 | -885.201630987625 | -885.39326244011 | -884.484292923748 | 0.000957440676377755 | 0.000359476534005587 | 0.131034895686845 |
| 43 | 43 | SKCM | vemurafenib | MITF | -218.159268930526 | -227.902276315964 | -215.872316038692 | 0.00067876692921172 | 0.0178162819133137 | 0.170048582189801 |
| 44 | 44 | SKCM | vemurafenib | NFKBIE | -204.472328962734 | -205.770859944176 | -203.463528564534 | 0.000791743570073073 | 0.00206511518866459 | 0.111608299527157 |
| 45 | 45 | SKCM | vemurafenib | NRAS | 190.105659110612 | 190.105659129594 | 194.65638402513 | 0.000176394754843052 | -0.00111871355100934 | 0.126593226794203 |
| 46 | 46 | SKCM | vemurafenib | PPP6C | -706.297968991354 | -709.764686258733 | -705.725598738114 | 0.00176652515500982 | 0.00709107889323635 | 0.137890393145552 |
| 47 | 47 | SKCM | vemurafenib | PREX2 | -344.790335003763 | -344.790334982403 | -344.433418301189 | 0.000300045733008128 | -0.000994902405906828 | 0.15199111409033 |
| 48 | 48 | SKCM | vemurafenib | PTPRT | -93.6994155097067 | -98.7852514869157 | -92.1099532701139 | 0.00182773947834294 | 0.00986942017329018 | 0.213506946653987 |
| 49 | 49 | SKCM | vemurafenib | RAC1 | -40.9133567283327 | -40.9133567000627 | -37.9995935322292 | 0.00118473832586125 | -0.000109063818864774 | 0.219272336900158 |
| 50 | 50 | SKCM | vemurafenib | SALL4 | 5.46924780606177 | 5.46924783653319 | 10.3364814081467 | 0.000831049007395616 | -0.000463211103613137 | 0.230826716958423 |
| 51 | 51 | SKCM | vemurafenib | SFRP4 | -199.223737941647 | -199.376471570544 | -198.612094853 | 0.00339276863641014 | 0.00270947659599829 | 0.201316053308107 |
| 52 | 52 | SKCM | vemurafenib | STAG2 | -273.693126333853 | -273.693126284958 | -272.805949730465 | 0.0042001033309383 | 0.00291020707173861 | 0.234702214576093 |
| 53 | 53 | SKCM | vemurafenib | TERT | 185.661558302926 | 177.961889773122 | 192.06011121337 | 0.00211816320060312 | 0.0169643658396839 | 0.249046910078381 |
| 54 | 54 | SKCM | vemurafenib | TRRAP | 28.7815025968615 | 28.7815026128351 | 32.8247846514909 | 0.0015898749542753 | 0.000296597582853941 | 0.174491079674142 |
| 55 | 55 | SKCM | dacarbazine | ATF1 | -927.785372076122 | -927.816829814549 | -927.548933112155 | 0.000603700784559494 | -0.000494436314937285 | 0.0923394508649707 |
| 56 | 56 | SKCM | dacarbazine | B2M | -677.157672500767 | -673.860795785104 | -676.463198777939 | 0.000763167891826715 | 0.00177997687340337 | 0.10176473671857 |
| 57 | 57 | SKCM | dacarbazine | BAP1 | -394.174770507246 | -393.669339973856 | -388.700191143094 | 0.00198233992117266 | 0.00206056994114501 | 0.153641032907888 |
| 58 | 58 | SKCM | dacarbazine | BRAF | -456.072827970274 | -456.07282791412 | -454.613161633351 | 0.000736438472650778 | -0.000632415757656934 | 0.13334191405876 |
| 59 | 59 | SKCM | dacarbazine | CDKN2A | 846.878588465721 | 846.87858847037 | 846.878853680095 | 0.00102514172237785 | -0.000343316990457421 | 0.620955975645402 |
| 60 | 60 | SKCM | dacarbazine | CUX1 | -81.818251060048 | -83.2132325675874 | -81.4051272574037 | 2.1312120036516e-06 | 0.00415175073996443 | 0.168073954384673 |
| 61 | 61 | SKCM | dacarbazine | ERBB4 | -1144.44688810455 | -1146.14847393883 | -1141.39884242841 | 0.00186145484707106 | 0.00400562265645144 | 0.0734054841265443 |
| 62 | 62 | SKCM | dacarbazine | FAT4 | -911.447801129853 | -910.200201141976 | -911.416931860854 | 7.18227900015048e-05 | 0.00216422516880976 | 0.145677521727823 |
| 63 | 63 | SKCM | dacarbazine | GNA11 | -808.255411597488 | -808.255411559389 | -808.103048956487 | 0.00112820657323469 | -0.000240110948049654 | 0.133231090000889 |
| 64 | 64 | SKCM | dacarbazine | GNAQ | -596.546484235038 | -596.546484203372 | -596.026836458704 | 0.00114646665946235 | -0.000221825867593672 | 0.136583337441975 |
| 65 | 65 | SKCM | dacarbazine | GRIN2A | -706.954100572119 | -706.954100518237 | -705.464114074421 | 2.86609995942256e-05 | -0.00134116274856022 | 0.114999740991162 |
| 66 | 66 | SKCM | dacarbazine | IRS4 | -264.576387439785 | -264.734901409332 | -263.816875468394 | 0.00255300477591837 | 0.00329593454739974 | 0.236908146533476 |
| 67 | 67 | SKCM | dacarbazine | KIT | -0.512068864693784 | -0.512068850320212 | 4.63267000331619 | 6.83310441082709e-05 | -0.0013014383746206 | 0.144080756765346 |
| 68 | 68 | SKCM | dacarbazine | MAP2K1 | -850.674896649491 | -850.485080871874 | -847.134475738541 | 0.00200318064819209 | 0.0039042692975948 | 0.0999862226789769 |
| 69 | 69 | SKCM | dacarbazine | MAP2K2 | -852.920536036176 | -852.920535965663 | -852.48065625648 | 0.00126332018704854 | -0.000104812258089781 | 0.130155377189993 |
| 70 | 70 | SKCM | dacarbazine | MITF | -215.37108896185 | -215.452829056182 | -213.258809100923 | 0.000997704396967943 | 0.000100769514089993 | 0.16738690703619 |
| 71 | 71 | SKCM | dacarbazine | NFKBIE | -244.257973900416 | -245.320736698926 | -243.379428113993 | 8.31908077126912e-06 | 0.000970136404090272 | 0.110732848519969 |
| 72 | 72 | SKCM | dacarbazine | NRAS | 254.455156455429 | 254.455156471039 | 261.427893997089 | 0.0006263990697521 | -0.000742605870782009 | 0.12961847126696 |
| 73 | 73 | SKCM | dacarbazine | PPP6C | -671.598800822208 | -671.59880074312 | -670.425940741951 | 0.000153070699639637 | -0.00121658242122757 | 0.137682234263707 |
| 74 | 74 | SKCM | dacarbazine | PREX2 | -307.59014542185 | -307.590145394949 | -307.165804291045 | 0.0031965943470587 | 0.00183111021274895 | 0.162907507472073 |
| 75 | 75 | SKCM | dacarbazine | PTPRT | -111.02933514286 | -111.570069993492 | -107.126882012163 | 0.00550608085413282 | 0.00558520697344389 | 0.211413952564944 |
| 76 | 76 | SKCM | dacarbazine | RAC1 | -85.6223350394107 | -85.6222445450904 | -83.6161897003816 | 0.00407509657529325 | 0.00271111367340704 | 0.213098074922239 |
| 77 | 77 | SKCM | dacarbazine | SALL4 | -40.9553914107501 | -40.9553913887926 | -37.349487151754 | 0.00203507869434856 | 0.000668003736632339 | 0.224966442164386 |
| 78 | 78 | SKCM | dacarbazine | SFRP4 | -265.040638986859 | -266.118926700315 | -264.506728368896 | 0.00123573665011014 | 0.00738521557044247 | 0.198806284907665 |
| 79 | 79 | SKCM | dacarbazine | STAG2 | -259.176837913683 | -259.176837877622 | -258.58776570758 | 0.000586567023052023 | -0.000782492489959763 | 0.24688787679369 |
| 80 | 80 | SKCM | dacarbazine | TERT | 134.538827593297 | 134.540956321065 | 139.49012262501 | 0.000180985294833229 | -0.00118940938715983 | 0.244136327404759 |
| 81 | 81 | SKCM | dacarbazine | TRRAP | 165.652517790594 | 160.767883015674 | 170.170155392407 | 0.00177187925035965 | 0.0110158469634611 | 0.182719439676242 |
| 82 | 82 | SKCM | trametinib | ATF1 | -1146.42650099043 | -1150.64611661854 | -1145.08371275776 | 0.0014281641632027 | 0.00957756565504786 | 0.0898482262515658 |
| 83 | 83 | SKCM | trametinib | B2M | -865.537845987122 | -865.530337666705 | -864.16683405711 | 0.000563772915140079 | 0.00714231547181476 | 0.0976185257976429 |
| 84 | 84 | SKCM | trametinib | BAP1 | -532.981157533677 | -534.333933820573 | -527.238676883123 | 0.000500870805614567 | 0.00167450941653402 | 0.156256029182209 |
| 85 | 85 | SKCM | trametinib | BRAF | -607.524328361196 | -610.705711554548 | -605.968556663864 | 0.00871754217981313 | 0.0141966042225109 | 0.133958900847277 |
| 86 | 86 | SKCM | trametinib | CDKN2A | 1049.30806671749 | 1047.18598246391 | 1049.30899519672 | 0.00032506384170002 | 0.00246680931806698 | 0.629872165301659 |
| 87 | 87 | SKCM | trametinib | CUX1 | -168.786690669783 | -166.931370713446 | -168.261026920171 | 0.00483978811701025 | 0.0100483472675854 | 0.163185154882361 |
| 88 | 88 | SKCM | trametinib | ERBB4 | -1431.46022725498 | -1434.94090678265 | -1426.81484157247 | 0.0029588331499298 | 0.00961901264249743 | 0.0735369664094087 |
| 89 | 89 | SKCM | trametinib | FAT4 | -1122.5808594162 | -1122.58085936372 | -1122.47326483691 | 0.000219858397917838 | -0.000880009770258816 | 0.145982354334236 |
| 90 | 90 | SKCM | trametinib | GNA11 | -981.286378092386 | -981.844964515067 | -980.801864488834 | 7.44394753012952e-05 | 0.00356153200505371 | 0.127660963292605 |
| 91 | 91 | SKCM | trametinib | GNAQ | -702.598976152459 | -702.598976095364 | -702.191766967849 | 0.000436414838172638 | -0.00066321508670919 | 0.136967771835528 |
| 92 | 92 | SKCM | trametinib | GRIN2A | -917.887467524514 | -917.887467464238 | -916.975943853685 | 0.000337834225873445 | -0.000761904120959667 | 0.111570718547456 |
| 93 | 93 | SKCM | trametinib | IRS4 | -326.673830530352 | -326.673830474299 | -325.5060034562 | 9.01884170682771e-05 | -0.00100982238617942 | 0.235438263196767 |
| 94 | 94 | SKCM | trametinib | KIT | -86.4798931214138 | -84.6675297793534 | -77.5872260839393 | 0.00180901561865351 | 0.00255669659623414 | 0.140830989497785 |
| 95 | 95 | SKCM | trametinib | MAP2K1 | -1103.49887286794 | -1103.38326366218 | -1099.36977067878 | 2.00051754704853e-06 | -0.00106586170051304 | 0.0969937249550681 |
| 96 | 96 | SKCM | trametinib | MAP2K2 | -1039.30661480188 | -1040.29678341215 | -1038.40897584822 | 0.000108825326031872 | 0.00373065347283352 | 0.127305986603891 |
| 97 | 97 | SKCM | trametinib | MITF | -212.696340148719 | -237.193935078571 | -208.782964200843 | 0.000692221713153491 | 0.0295865446955428 | 0.162492312065567 |
| 98 | 98 | SKCM | trametinib | NFKBIE | -257.490927822305 | -257.838681322351 | -257.294719205333 | 4.22724933677416e-05 | 0.00422656124009091 | 0.112745252581488 |
| 99 | 99 | SKCM | trametinib | NRAS | 199.038578491078 | 199.035885322005 | 205.586534596837 | 0.000860260252458604 | -8.4868729140597e-05 | 0.125512303772202 |
| 100 | 100 | SKCM | trametinib | PPP6C | -831.670335656255 | -831.670335602088 | -830.632468988384 | 0.000251942580592079 | -0.00084789029316723 | 0.135652826900403 |