Downloads: 1
[b8e226]:
/
BRCA_ec50_fit_table.csv
| # | cancer | drug | gene | lm_result_aic | gam_result_aic | rlm_result_aic | lm_result_r2 | gam_result_r2 | rlm_result_mse | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | BRCA | fulvestrant | AKT1 | -135.318725743508 | -135.318725733767 | -134.064174036143 | 0.0105593404274078 | 0.00796918162068394 | 0.142366473252261 |
| 2 | 2 | BRCA | fulvestrant | ARID1A | -340.244108119455 | -340.244108085221 | -339.916299209053 | 0.00406327439083147 | 0.00145611015276637 | 0.122853412671389 |
| 3 | 3 | BRCA | fulvestrant | ARID1B | -339.999802624755 | -339.99980260637 | -339.521169436422 | 0.0011277973811237 | -0.0014870513360139 | 0.138510070951071 |
| 4 | 4 | BRCA | fulvestrant | BAP1 | -221.856312470198 | -222.912648778717 | -219.157878038067 | 0.00366508675666984 | 0.00549844916460851 | 0.158901629972114 |
| 5 | 5 | BRCA | fulvestrant | BARD1 | -584.224892843661 | -584.224892809061 | -582.319613705752 | 0.00389979897121509 | 0.00129220678369246 | 0.0731322663667955 |
| 6 | 6 | BRCA | fulvestrant | BRCA2 | -246.90796675493 | -246.907966728651 | -246.334032703399 | 0.010359665560927 | 0.007768984034628 | 0.162039402264928 |
| 7 | 7 | BRCA | fulvestrant | CASP8 | -575.442294006199 | -573.438309229937 | -575.076882968069 | 0.00300482095605081 | 0.00960081773592125 | 0.0647084883859519 |
| 8 | 8 | BRCA | fulvestrant | CCND1 | 635.267009486186 | 635.267009490088 | 662.565055959585 | 0.00204185388069064 | -0.000570602000607101 | 0.178672860836669 |
| 9 | 9 | BRCA | fulvestrant | CDH1 | -439.325384810189 | -440.107254962809 | -438.515377850919 | 9.96866683411845e-06 | 0.0052487110701438 | 0.116407391027209 |
| 10 | 10 | BRCA | fulvestrant | CDKN1B | -189.405891350353 | -189.405891326349 | -189.108347507306 | 0.00113371979236165 | -0.00148111341047397 | 0.119569049394778 |
| 11 | 11 | BRCA | fulvestrant | CTCF | -339.843177694818 | -339.843177660828 | -339.256272566336 | 0.000116928303583794 | -0.00250056668764387 | 0.113365582225663 |
| 12 | 12 | BRCA | fulvestrant | EP300 | -295.505431343697 | -297.277913024105 | -294.66538706749 | 0.00506126205355869 | 0.015761982084221 | 0.142280693522783 |
| 13 | 13 | BRCA | fulvestrant | ERBB2 | 674.974374231148 | 674.974374233869 | 688.672990682577 | 0.0163482604291764 | 0.0137732558721462 | 0.116635706530591 |
| 14 | 14 | BRCA | fulvestrant | ESR1 | -378.330114035103 | -378.330113998879 | -377.983403671823 | 0.000374087694442764 | -0.00224273410612419 | 0.134056542321206 |
| 15 | 15 | BRCA | fulvestrant | ETV6 | -183.607929996032 | -183.607929979014 | -182.730340386589 | 0.00119551373209493 | -0.00141915771748891 | 0.121717918895317 |
| 16 | 16 | BRCA | fulvestrant | FOXA1 | 58.5077023182526 | 58.5077023246881 | 62.5941544356727 | 0.0114923439515218 | 0.00890462757122168 | 0.153136634282423 |
| 17 | 17 | BRCA | fulvestrant | GATA3 | -193.128148001292 | -196.525286218054 | -193.109827981304 | 2.4038053484008e-07 | 0.01408032968148 | 0.158397675801138 |
| 18 | 18 | BRCA | fulvestrant | IKZF3 | 676.70844505549 | 676.708445057278 | 690.230579874352 | 0.0170844947057917 | 0.0145114174645266 | 0.113540693683036 |
| 19 | 19 | BRCA | fulvestrant | IRS4 | -144.981007040751 | -144.830803075586 | -144.67702685298 | 3.2488462614273e-06 | 0.00204998281719293 | 0.237313792525377 |
| 20 | 20 | BRCA | fulvestrant | KEAP1 | -265.959180935665 | -265.959180905276 | -264.056885234203 | 0.000959862665798626 | -0.00165542568495658 | 0.122681035142903 |
| 21 | 21 | BRCA | fulvestrant | MAP2K4 | -18.8116811546813 | -21.3953782282359 | -17.2457601837511 | 0.00834949829453215 | 0.0145361563159856 | 0.16393807839063 |
| 22 | 22 | BRCA | fulvestrant | MAP3K1 | -250.001110867066 | -250.001110853319 | -249.969091807174 | 0.00206587316582908 | -0.000546519806606138 | 0.123497516630068 |
| 23 | 23 | BRCA | fulvestrant | MAP3K13 | -140.210439543685 | -141.683447229566 | -136.698094887898 | 3.39943760561679e-05 | 0.00503894681573847 | 0.158369266136618 |
| 24 | 24 | BRCA | fulvestrant | NCOR1 | 57.9484147261049 | 57.7215374022902 | 58.9859094875225 | 0.000963992040514111 | 1.33953416476817e-05 | 0.169711450319823 |
| 25 | 25 | BRCA | fulvestrant | NOTCH1 | -315.054146949701 | -315.054146912649 | -314.192110961155 | 0.00247070832520192 | -0.000140624945858203 | 0.137277786526091 |
| 26 | 26 | BRCA | fulvestrant | NTRK3 | -360.202914198685 | -360.202914154311 | -359.220265428176 | 0.00303783047514787 | 0.000427981807154532 | 0.10682543503292 |
| 27 | 27 | BRCA | fulvestrant | PBRM1 | -288.348568370634 | -288.348568338631 | -288.124729472092 | 0.000687126961890335 | -0.00192887535887021 | 0.161810868236324 |
| 28 | 28 | BRCA | fulvestrant | PIK3CA | -56.6485999826836 | -56.918579163866 | -53.0849947280475 | 0.000233567894191653 | -0.000103162631263976 | 0.160934735097702 |
| 29 | 29 | BRCA | fulvestrant | PPM1D | 8.61261096358129 | 7.88381233254858 | 11.6490155309174 | 0.00998836364670725 | 0.0107294372874353 | 0.129880453381718 |
| 30 | 30 | BRCA | fulvestrant | RB1 | -159.009749455944 | -158.256212075983 | -158.998243549292 | 0.0111757539117036 | 0.0120809926352657 | 0.159686843985683 |
| 31 | 31 | BRCA | fulvestrant | SALL4 | 0.0821738561069765 | -0.767502673281325 | 3.26939880354803 | 0.000184031069682373 | 0.00133865548356837 | 0.224869859924952 |
| 32 | 32 | BRCA | fulvestrant | TBX3 | -539.430068585204 | -539.455460428466 | -539.416249070105 | 4.13148295378469e-05 | -0.0021245502264049 | 0.0819601684150693 |
| 33 | 33 | BRCA | fulvestrant | TP53 | -94.8918700444672 | -94.8918700335178 | -94.2115601266229 | 0.020848120453963 | 0.0182848956283873 | 0.167058663508849 |
| 34 | 34 | BRCA | doxorubicin | AKT1 | -167.404924663022 | -167.404924637648 | -166.731887365352 | 0.000612984652058984 | -0.00155019021268599 | 0.138644366425423 |
| 35 | 35 | BRCA | doxorubicin | ARID1A | -423.366891302155 | -421.37890997014 | -423.054932382354 | 0.00667568542284811 | 0.00867132050697439 | 0.118027913686573 |
| 36 | 36 | BRCA | doxorubicin | ARID1B | -419.82718638092 | -419.926673022893 | -419.294482248615 | 0.0287456007465919 | 0.0384876553921969 | 0.131521260681517 |
| 37 | 37 | BRCA | doxorubicin | BAP1 | -252.451507259855 | -253.530916377867 | -249.674159830424 | 2.64193483532245e-05 | 0.00230399954652338 | 0.162687465786378 |
| 38 | 38 | BRCA | doxorubicin | BARD1 | -703.53746097386 | -703.537460897624 | -701.160828765325 | 1.98466242106879e-05 | -0.00214461254247822 | 0.0755557874335636 |
| 39 | 39 | BRCA | doxorubicin | BRCA2 | -278.526458041283 | -278.526458026171 | -278.172727445037 | 0.00154308604886658 | -0.000618076109349053 | 0.160051774653026 |
| 40 | 40 | BRCA | doxorubicin | CASP8 | -711.008637948556 | -711.0086378859 | -710.862282962091 | 0.00129589147998654 | -0.000865805709019618 | 0.0677879767670522 |
| 41 | 41 | BRCA | doxorubicin | CCND1 | 706.166574923677 | 706.166574927571 | 738.311508960914 | 0.00396709276473835 | 0.0018111773823376 | 0.144534872474165 |
| 42 | 42 | BRCA | doxorubicin | CDH1 | -526.65206881912 | -526.652068786633 | -525.575689916344 | 0.00184672402820515 | -0.000313780926448182 | 0.112917938224829 |
| 43 | 43 | BRCA | doxorubicin | CDKN1B | -254.392490573769 | -254.656882548932 | -253.026412441992 | 0.000805404899087013 | 0.00273989262180174 | 0.124721324409345 |
| 44 | 44 | BRCA | doxorubicin | CTCF | -403.921348888564 | -403.921348839664 | -402.862337480126 | 0.00986871693773128 | 0.0077255756802298 | 0.10952843390858 |
| 45 | 45 | BRCA | doxorubicin | EP300 | -338.550686576391 | -338.550686539174 | -337.918943635095 | 0.000114809970585135 | -0.00204944372310467 | 0.144402341930328 |
| 46 | 46 | BRCA | doxorubicin | ERBB2 | 822.79578544916 | 817.211465847824 | 836.511084876465 | 0.000860306860028899 | 0.0191291094637588 | 0.106335214764798 |
| 47 | 47 | BRCA | doxorubicin | ESR1 | -453.649287658075 | -456.109017847679 | -453.493494673095 | 0.0335341316117611 | 0.0409791088584609 | 0.131880596197254 |
| 48 | 48 | BRCA | doxorubicin | ETV6 | -234.125230862525 | -234.125230832916 | -232.239374513117 | 4.6784051331959e-05 | -0.00211761682255518 | 0.12772239475632 |
| 49 | 49 | BRCA | doxorubicin | FOXA1 | 116.535345773593 | 114.584927628409 | 121.40918547901 | 9.41537970415287e-05 | 0.00405569091901159 | 0.149083785878339 |
| 50 | 50 | BRCA | doxorubicin | GATA3 | -236.018692575988 | -239.336385594384 | -235.976036981388 | 0.00113134944260256 | 0.00890704101622741 | 0.155984116083755 |
| 51 | 51 | BRCA | doxorubicin | IKZF3 | 824.83549191242 | 819.648893833474 | 838.14870956572 | 0.000834874311253927 | 0.0185361150224588 | 0.104543413751006 |
| 52 | 52 | BRCA | doxorubicin | IRS4 | -156.938813887289 | -155.670499485062 | -156.24289678798 | 0.000797956675900131 | 0.0119138038198461 | 0.234855871597103 |
| 53 | 53 | BRCA | doxorubicin | KEAP1 | -298.608386601016 | -295.945688527811 | -297.696047460237 | 0.00655824226171396 | 0.0148738242949854 | 0.119925575644751 |
| 54 | 54 | BRCA | doxorubicin | MAP2K4 | -52.6422330306052 | -52.6422330092803 | -50.6378421650207 | 0.00661958087466093 | 0.00446940688085651 | 0.163998879800029 |
| 55 | 55 | BRCA | doxorubicin | MAP3K1 | -323.988962976062 | -323.998791295843 | -323.762254457955 | 0.000992931221790494 | -0.00092925912054298 | 0.121853920540056 |
| 56 | 56 | BRCA | doxorubicin | MAP3K13 | -158.048019431802 | -158.121524771281 | -154.333004867937 | 0.00069173551041061 | -0.000805394378364355 | 0.159880244961287 |
| 57 | 57 | BRCA | doxorubicin | NCOR1 | 79.2260436523016 | 79.2260436614583 | 82.6676672161369 | 3.70502222075238e-06 | -0.0021607891315274 | 0.16015533815923 |
| 58 | 58 | BRCA | doxorubicin | NOTCH1 | -402.416480396869 | -402.416480357584 | -401.858127343427 | 1.09904201148493e-05 | -0.00215348794624037 | 0.134683127728743 |
| 59 | 59 | BRCA | doxorubicin | NTRK3 | -445.719900151736 | -450.165949486812 | -444.604591588021 | 0.00129518566825905 | 0.0177791283353906 | 0.109821358928742 |
| 60 | 60 | BRCA | doxorubicin | PBRM1 | -360.810449457801 | -363.309841987798 | -360.445256560341 | 0.00152074800634829 | 0.0170118888815384 | 0.155986188961789 |
| 61 | 61 | BRCA | doxorubicin | PIK3CA | -73.5151585671941 | -73.5632293525727 | -69.5523490917779 | 0.00164003313173555 | 2.78128915381926e-05 | 0.16019661669049 |
| 62 | 62 | BRCA | doxorubicin | PPM1D | -43.3137394271592 | -47.6820233182283 | -39.3259463067066 | 0.0123146927630107 | 0.0236853068516204 | 0.132783337639709 |
| 63 | 63 | BRCA | doxorubicin | RB1 | -173.194309067019 | -173.194309042615 | -173.099149593394 | 0.00164473487728059 | -0.000516207279670056 | 0.162076040506919 |
| 64 | 64 | BRCA | doxorubicin | SALL4 | -14.9754728309301 | -17.8692809562212 | -12.1246754520567 | 0.0155333687370582 | 0.0227695553831511 | 0.221098545616129 |
| 65 | 65 | BRCA | doxorubicin | TBX3 | -666.476414357816 | -671.131666201314 | -666.45640902638 | 0.000308750128982273 | 0.0106302229887549 | 0.082165256627169 |
| 66 | 66 | BRCA | doxorubicin | TP53 | -123.385908989995 | -123.385908977274 | -122.60848928667 | 0.0115264886996137 | 0.00938693565812099 | 0.166426028012254 |
| 67 | 67 | BRCA | ixabepilone | AKT1 | -167.774278867889 | -177.308135067556 | -166.916927547922 | 0.00140820214874266 | 0.0246193512880808 | 0.139144867441612 |
| 68 | 68 | BRCA | ixabepilone | ARID1A | -421.841997895248 | -421.841997858422 | -420.969708555654 | 0.00340584617537229 | 0.00124871593560527 | 0.123724018049425 |
| 69 | 69 | BRCA | ixabepilone | ARID1B | -406.420355919956 | -406.420355883497 | -406.133381205414 | 0.000272779457746277 | -0.00189113230715576 | 0.136549146623027 |
| 70 | 70 | BRCA | ixabepilone | BAP1 | -254.054072452833 | -254.054072435557 | -250.986286165534 | 0.00347417503232039 | 0.00131719271029895 | 0.156930274671323 |
| 71 | 71 | BRCA | ixabepilone | BARD1 | -703.528589618708 | -702.018220127854 | -701.144434744554 | 7.27520996000501e-07 | 0.00436325521814496 | 0.0759289036788009 |
| 72 | 72 | BRCA | ixabepilone | BRCA2 | -279.232348575046 | -279.232348548437 | -278.652522457816 | 0.00306089950365988 | 0.000903022636606354 | 0.161713213121094 |
| 73 | 73 | BRCA | ixabepilone | CASP8 | -710.556546865562 | -710.556546821328 | -710.299593175652 | 0.00032234567834329 | -0.00184145880172859 | 0.0677105133052059 |
| 74 | 74 | BRCA | ixabepilone | CCND1 | 707.993219978664 | 692.447753897169 | 739.115448244308 | 3.82467867685821e-05 | 0.0345460892940714 | 0.157730571307881 |
| 75 | 75 | BRCA | ixabepilone | CDH1 | -527.5009784971 | -527.500978467278 | -526.241105111921 | 0.00367122256852185 | 0.00151466809806122 | 0.111659182426595 |
| 76 | 76 | BRCA | ixabepilone | CDKN1B | -254.035552954681 | -254.28493054714 | -253.352260002989 | 3.64666368401991e-05 | -0.000706743669804721 | 0.124544603449046 |
| 77 | 77 | BRCA | ixabepilone | CTCF | -399.835747400936 | -399.835747374201 | -398.445891515392 | 0.00111194120634522 | -0.00105015418214127 | 0.114353440565012 |
| 78 | 78 | BRCA | ixabepilone | EP300 | -340.990598470451 | -340.990598439647 | -340.422966764045 | 0.00535883729545924 | 0.00320593432661076 | 0.143447499635853 |
| 79 | 79 | BRCA | ixabepilone | ERBB2 | 823.057594697957 | 823.057594701367 | 836.212142895797 | 0.00029638913373502 | -0.00186747149451438 | 0.104285278513518 |
| 80 | 80 | BRCA | ixabepilone | ESR1 | -438.294974530348 | -438.294974496163 | -438.152956222701 | 0.00101758543278046 | -0.00114471419625772 | 0.133817504651426 |
| 81 | 81 | BRCA | ixabepilone | ETV6 | -234.328439836722 | -234.82471894262 | -232.533107238626 | 0.000484618055883427 | 0.000617727542291946 | 0.126669725140448 |
| 82 | 82 | BRCA | ixabepilone | FOXA1 | 112.837418700486 | 112.837418714422 | 118.270268120633 | 0.00803140319604652 | 0.00588428502056637 | 0.148804083731731 |
| 83 | 83 | BRCA | ixabepilone | GATA3 | -235.50305035163 | -235.5030503385 | -235.457324255064 | 2.06917900828493e-05 | -0.0021437655822667 | 0.157003366290349 |
| 84 | 84 | BRCA | ixabepilone | IKZF3 | 825.088551488192 | 825.088551491357 | 837.796462587905 | 0.000289793997761588 | -0.00187408090730168 | 0.104642588786508 |
| 85 | 85 | BRCA | ixabepilone | IRS4 | -156.573733835954 | -156.573733822574 | -155.915946144873 | 1.14646916084021e-05 | -0.00215301266049694 | 0.235697660283729 |
| 86 | 86 | BRCA | ixabepilone | KEAP1 | -296.28988448855 | -296.289884465356 | -295.51463633317 | 0.00158181783311055 | -0.000579260498296597 | 0.124702882846171 |
| 87 | 87 | BRCA | ixabepilone | MAP2K4 | -51.1698784330283 | -47.444673622163 | -49.2788016328632 | 0.00346240147414698 | 0.00362631894436494 | 0.159083122897649 |
| 88 | 88 | BRCA | ixabepilone | MAP3K1 | -323.56763744339 | -323.567637410189 | -323.394801225801 | 8.53916932350869e-05 | -0.00207892552456634 | 0.120028149876985 |
| 89 | 89 | BRCA | ixabepilone | MAP3K13 | -163.486068965456 | -161.865818791764 | -160.058166388252 | 0.0123351991651641 | 0.0203857617004746 | 0.160623371043582 |
| 90 | 90 | BRCA | ixabepilone | NCOR1 | 77.1082060834396 | 77.9180248068404 | 78.4370344344311 | 0.00455759264453284 | 0.00994159128522032 | 0.15940729679197 |
| 91 | 91 | BRCA | ixabepilone | NOTCH1 | -403.117252580769 | -403.117252543406 | -402.498590078361 | 0.00152011880679917 | -0.000641092701446411 | 0.134683621524062 |
| 92 | 92 | BRCA | ixabepilone | NTRK3 | -446.035848507758 | -446.120661744141 | -444.955474656017 | 0.00197499545200693 | 0.0124374863582678 | 0.11322367226638 |
| 93 | 93 | BRCA | ixabepilone | PBRM1 | -362.967162884234 | -364.333375042035 | -362.663449251978 | 0.00615099946757691 | 0.00883222118378235 | 0.159478930350026 |
| 94 | 94 | BRCA | ixabepilone | PIK3CA | -78.5202070063939 | -76.3440482663162 | -74.6527985920142 | 0.0123512116245942 | 0.0196657756623282 | 0.165459454848679 |
| 95 | 95 | BRCA | ixabepilone | PPM1D | -39.6349638578198 | -36.1070499595474 | -35.9090666857082 | 0.00445280801209182 | 0.00830346703946105 | 0.129307253909654 |
| 96 | 96 | BRCA | ixabepilone | RB1 | -172.721908147776 | -172.721908133539 | -172.590411551045 | 0.000627786368829397 | -0.00153535696399465 | 0.162701361439649 |
| 97 | 97 | BRCA | ixabepilone | SALL4 | -8.45153581699218 | -8.45153580764129 | -5.58617398754742 | 0.00159379504869692 | -0.000567257347966921 | 0.224580168277933 |
| 98 | 98 | BRCA | ixabepilone | TBX3 | -666.408759111444 | -665.319794646229 | -666.246651699083 | 0.000162975799487582 | 0.0101078240617601 | 0.0818253477638952 |
| 99 | 99 | BRCA | ixabepilone | TP53 | -119.167539532488 | -119.167539514237 | -118.378759338483 | 0.00249899241469438 | 0.00033989930748346 | 0.164062713838864 |
| 100 | 100 | BRCA | docetaxel | AKT1 | -331.427446635448 | -331.427446600799 | -329.645598185684 | 0.00341606955307305 | 0.00232212453576197 | 0.141309925755498 |