Downloads: 1
[2c7117]:
/
BRCA_auc_fit_table.csv
| # | cancer | drug | gene | lm_result_aic | gam_result_aic | rlm_result_aic | lm_result_r2 | gam_result_r2 | rlm_result_mse | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | BRCA | fulvestrant | AKT1 | -131.410912621613 | -132.553396110281 | -130.463515932652 | 0.000438792882025893 | 0.00559225055064094 | 0.142082141696878 |
| 2 | 2 | BRCA | fulvestrant | ARID1A | -338.955233200713 | -338.955233162036 | -338.817399915798 | 0.000714851191573982 | -0.00190107856687294 | 0.121672088153722 |
| 3 | 3 | BRCA | fulvestrant | ARID1B | -340.781388245091 | -342.168714252228 | -340.264117014526 | 0.00315881346026569 | 0.0133256933006078 | 0.139154441347864 |
| 4 | 4 | BRCA | fulvestrant | BAP1 | -226.616719268304 | -226.616719247206 | -223.963687417823 | 0.0159402993191079 | 0.0133642268195974 | 0.158291878155778 |
| 5 | 5 | BRCA | fulvestrant | BARD1 | -582.875677407981 | -580.41185545647 | -581.124877234364 | 0.000393763606174194 | 0.00482699795495267 | 0.0762918787397647 |
| 6 | 6 | BRCA | fulvestrant | BRCA2 | -243.594860729318 | -243.594860699559 | -242.623289829203 | 0.0017842265057746 | -0.000828903826042282 | 0.15613574268295 |
| 7 | 7 | BRCA | fulvestrant | CASP8 | -575.043436651442 | -575.337210653245 | -574.344088367605 | 0.00196871300374139 | 0.00128467683076228 | 0.065452079440692 |
| 8 | 8 | BRCA | fulvestrant | CCND1 | 635.570522741226 | 635.570522743028 | 662.748937268117 | 0.00125275684878728 | -0.00136176473212801 | 0.178517454333902 |
| 9 | 9 | BRCA | fulvestrant | CDH1 | -439.570840120189 | -440.275813952191 | -438.689415947171 | 0.000648964584315056 | 0.00443550593423259 | 0.112663109168989 |
| 10 | 10 | BRCA | fulvestrant | CDKN1B | -188.970408349147 | -194.567736059659 | -188.271760871679 | 2.92623105966293e-07 | 0.0184177891080038 | 0.113442719378399 |
| 11 | 11 | BRCA | fulvestrant | CTCF | -339.978710398519 | -343.206651329369 | -339.348012484491 | 0.000469774510835779 | 0.0119802747512688 | 0.113379471839789 |
| 12 | 12 | BRCA | fulvestrant | EP300 | -293.601344675683 | -293.601344640731 | -292.686144583899 | 0.000115547914661397 | -0.00250195062216974 | 0.138236239115818 |
| 13 | 13 | BRCA | fulvestrant | ERBB2 | 679.898460898333 | 679.898460901241 | 691.206021780002 | 0.00365353495371688 | 0.00104529819010291 | 0.106174916277945 |
| 14 | 14 | BRCA | fulvestrant | ESR1 | -378.678933368668 | -378.67893333083 | -378.326222501165 | 0.00128171925917993 | -0.00133272630032621 | 0.136445635999647 |
| 15 | 15 | BRCA | fulvestrant | ETV6 | -183.366470438009 | -184.615668947992 | -182.344316874873 | 0.000567267039542561 | 0.0047221503684487 | 0.115657010384653 |
| 16 | 16 | BRCA | fulvestrant | FOXA1 | 62.6458610772661 | 62.6458610901832 | 66.4479267278196 | 0.00078213015916334 | -0.00183362343772564 | 0.148368860479115 |
| 17 | 17 | BRCA | fulvestrant | GATA3 | -193.280739412032 | -193.280739386809 | -193.192342483497 | 0.0003975348081242 | -0.00221922558802423 | 0.159858612052691 |
| 18 | 18 | BRCA | fulvestrant | IKZF3 | 682.048207030207 | 682.048207032725 | 692.901115990286 | 0.00332096171140682 | 0.000711854291636227 | 0.105154124960077 |
| 19 | 19 | BRCA | fulvestrant | IRS4 | -145.039200780288 | -145.450088798568 | -144.70463684402 | 0.0001547830681161 | -0.000100344066546354 | 0.238612332764182 |
| 20 | 20 | BRCA | fulvestrant | KEAP1 | -266.541305599257 | -266.541305584226 | -264.777749960329 | 0.00247320983822997 | -0.000138116790668441 | 0.125693209063261 |
| 21 | 21 | BRCA | fulvestrant | MAP2K4 | -20.0623162920591 | -16.2887458296266 | -18.3160754164094 | 0.0115739138759372 | 0.0171956136912155 | 0.158774037334821 |
| 22 | 22 | BRCA | fulvestrant | MAP3K1 | -249.635217197425 | -249.645300939649 | -249.596706650438 | 0.00111454036527759 | -0.00103233680617487 | 0.122633306600501 |
| 23 | 23 | BRCA | fulvestrant | MAP3K13 | -140.281379471719 | -141.006358925022 | -136.797598832702 | 0.000218710429188469 | 0.0105411515697871 | 0.158267085065038 |
| 24 | 24 | BRCA | fulvestrant | NCOR1 | 58.2816646210467 | 57.3217324255506 | 59.5412720719308 | 9.66140441482801e-05 | 0.0152219565839677 | 0.163701548546853 |
| 25 | 25 | BRCA | fulvestrant | NOTCH1 | -315.262715389472 | -315.26271537038 | -314.510277940971 | 0.00301236623276662 | 0.000402450974012591 | 0.134416278424628 |
| 26 | 26 | BRCA | fulvestrant | NTRK3 | -359.863944860236 | -368.071638229323 | -358.654315270719 | 0.00215739087586791 | 0.0263406015814179 | 0.110168521787464 |
| 27 | 27 | BRCA | fulvestrant | PBRM1 | -290.162744480195 | -290.162744456929 | -289.854460139061 | 0.00539716279233679 | 0.00279349042541788 | 0.156899409367716 |
| 28 | 28 | BRCA | fulvestrant | PIK3CA | -56.5882254421705 | -56.5882254275076 | -53.0684015818526 | 7.63668934011506e-05 | -0.00254123424874608 | 0.161599735557534 |
| 29 | 29 | BRCA | fulvestrant | PPM1D | 10.5706804175844 | 10.5706804264712 | 14.125764378838 | 0.00492726384023079 | 0.00232236137855923 | 0.131957413474467 |
| 30 | 30 | BRCA | fulvestrant | RB1 | -154.793604712262 | -154.793604685792 | -154.739935818098 | 0.000259094684807072 | -0.00235802813012609 | 0.163607427663239 |
| 31 | 31 | BRCA | fulvestrant | SALL4 | -0.514520740132923 | -2.71314890167018 | 2.23157175954583 | 0.0017364308396546 | 0.00958129581927436 | 0.223204043291219 |
| 32 | 32 | BRCA | fulvestrant | TBX3 | -540.917518212973 | -540.917518147682 | -540.829347518518 | 0.00390722926014518 | 0.00129965651077357 | 0.081789365417025 |
| 33 | 33 | BRCA | fulvestrant | TP53 | -87.5997923319129 | -83.9027395299248 | -87.0571061599921 | 0.00207656628906647 | 0.00721191641774577 | 0.165363828959139 |
| 34 | 34 | BRCA | doxorubicin | AKT1 | -167.532534954047 | -167.532534928738 | -166.839957330151 | 0.000887800454665264 | -0.00127478006100512 | 0.139065317437735 |
| 35 | 35 | BRCA | doxorubicin | ARID1A | -424.749646109596 | -424.749646061459 | -424.494407372406 | 0.0096314599930841 | 0.0074878051030598 | 0.120242683813303 |
| 36 | 36 | BRCA | doxorubicin | ARID1B | -420.472016132736 | -420.472016102503 | -419.933032466289 | 0.0300944342563003 | 0.0279950718109526 | 0.130974331450917 |
| 37 | 37 | BRCA | doxorubicin | BAP1 | -252.457754706168 | -254.482096625656 | -249.654815800737 | 3.98832259422363e-05 | 0.00696074625952903 | 0.162741182166556 |
| 38 | 38 | BRCA | doxorubicin | BARD1 | -703.547807036439 | -703.547806965712 | -701.173275055547 | 4.21434817575129e-05 | -0.00212226719227759 | 0.0755804280703555 |
| 39 | 39 | BRCA | doxorubicin | BRCA2 | -278.546245232803 | -278.546245205043 | -278.191388680871 | 0.00158566414569247 | -0.00057540586938365 | 0.160447834602221 |
| 40 | 40 | BRCA | doxorubicin | CASP8 | -711.166985059356 | -711.166985014521 | -711.02412292072 | 0.00163665641322432 | -0.000524303175009067 | 0.0680297344027985 |
| 41 | 41 | BRCA | doxorubicin | CCND1 | 706.647190902284 | 706.647190906146 | 738.326303156101 | 0.00293485711369009 | 0.000776707460921178 | 0.14796575310919 |
| 42 | 42 | BRCA | doxorubicin | CDH1 | -527.20136069772 | -527.201360670658 | -526.159959994109 | 0.00302765740221534 | 0.000869708584520401 | 0.112782782008817 |
| 43 | 43 | BRCA | doxorubicin | CDKN1B | -254.153389092823 | -254.425956281942 | -253.014051333377 | 0.000290382326923471 | 0.00248561171763406 | 0.126609097358274 |
| 44 | 44 | BRCA | doxorubicin | CTCF | -404.587403269143 | -404.901374227026 | -403.557045465564 | 0.0112889931762365 | 0.0130688845681608 | 0.108970189550526 |
| 45 | 45 | BRCA | doxorubicin | EP300 | -338.509236635617 | -338.509236618464 | -337.849144643871 | 2.54844681098162e-05 | -0.00213896255299817 | 0.144816416491952 |
| 46 | 46 | BRCA | doxorubicin | ERBB2 | 822.753106791792 | 817.427528425691 | 836.557588824671 | 0.000952203367757811 | 0.0202330810831279 | 0.105498982275711 |
| 47 | 47 | BRCA | doxorubicin | ESR1 | -454.410920300858 | -454.846602622873 | -454.224295271062 | 0.0351192353940232 | 0.0368397160964282 | 0.127998568125001 |
| 48 | 48 | BRCA | doxorubicin | ETV6 | -234.131172505957 | -234.131172471664 | -232.403278043271 | 5.95886362831079e-05 | -0.00210478452755303 | 0.128202195402272 |
| 49 | 49 | BRCA | doxorubicin | FOXA1 | 116.543179864603 | 114.1645884613 | 121.401629565172 | 7.72714273651365e-05 | 0.00502696211483211 | 0.14896904583836 |
| 50 | 50 | BRCA | doxorubicin | GATA3 | -236.0097212638 | -239.780477978292 | -235.952049999338 | 0.00111203640568467 | 0.00983308965655649 | 0.156843062609543 |
| 51 | 51 | BRCA | doxorubicin | IKZF3 | 824.781371206661 | 819.569328457941 | 838.151187154959 | 0.000951409587599963 | 0.0201492013501126 | 0.105760764592836 |
| 52 | 52 | BRCA | doxorubicin | IRS4 | -156.986365905455 | -156.986365892458 | -156.323049840239 | 0.000900352449846953 | -0.00126220087947004 | 0.236770074116756 |
| 53 | 53 | BRCA | doxorubicin | KEAP1 | -299.383740066456 | -299.383740043306 | -298.419924952807 | 0.00821691747873907 | 0.00607020083451859 | 0.120362993326794 |
| 54 | 54 | BRCA | doxorubicin | MAP2K4 | -53.5046660871398 | -53.5046660763706 | -51.4657671206519 | 0.00846425417452077 | 0.00631807294303544 | 0.16264173948587 |
| 55 | 55 | BRCA | doxorubicin | MAP3K1 | -323.844358449126 | -323.844358432636 | -323.662355944219 | 0.000681544460185784 | -0.00148148247294144 | 0.121666103330925 |
| 56 | 56 | BRCA | doxorubicin | MAP3K13 | -157.909177538439 | -158.04994149655 | -154.144962832417 | 0.0003926695364823 | -0.000747490265392114 | 0.159271993461862 |
| 57 | 57 | BRCA | doxorubicin | NCOR1 | 79.1485092652622 | 79.1485092835457 | 82.7078162717896 | 0.000170790414809232 | -0.00199334209147417 | 0.159045274878842 |
| 58 | 58 | BRCA | doxorubicin | NOTCH1 | -402.419131606971 | -402.419131582841 | -401.843684064715 | 1.67041558684173e-05 | -0.00214776186807741 | 0.134994500976265 |
| 59 | 59 | BRCA | doxorubicin | NTRK3 | -445.566674347484 | -450.253114595821 | -444.439131621625 | 0.000965330887809151 | 0.0179384503407962 | 0.11032790019522 |
| 60 | 60 | BRCA | doxorubicin | PBRM1 | -360.774846526462 | -359.877343637148 | -360.402972312177 | 0.00144413129918472 | 0.00868466779282706 | 0.155711051771791 |
| 61 | 61 | BRCA | doxorubicin | PIK3CA | -73.2739691717366 | -73.4180710612125 | -69.3249404345383 | 0.00112094599684163 | 2.14500681913199e-05 | 0.160431753830801 |
| 62 | 62 | BRCA | doxorubicin | PPM1D | -43.6723102065692 | -46.8918367147224 | -39.4405111226922 | 0.013077663201281 | 0.02176839689348 | 0.132170749729328 |
| 63 | 63 | BRCA | doxorubicin | RB1 | -173.205413923863 | -173.205413894917 | -173.106056393641 | 0.00166862810924766 | -0.000492262333678273 | 0.162225332232848 |
| 64 | 64 | BRCA | doxorubicin | SALL4 | -14.9150062176336 | -16.7943328066846 | -11.9039907368218 | 0.015405068646654 | 0.0201843045837128 | 0.217587314336096 |
| 65 | 65 | BRCA | doxorubicin | TBX3 | -666.421582423505 | -669.931725863512 | -666.405638461068 | 0.00019060736200218 | 0.00789112036416884 | 0.0819873590411962 |
| 66 | 66 | BRCA | doxorubicin | TP53 | -124.093820692591 | -124.093820677429 | -123.311656902205 | 0.0130334249966127 | 0.0108971337140386 | 0.167747437706793 |
| 67 | 67 | BRCA | ixabepilone | AKT1 | -168.778933913704 | -175.762133667402 | -168.112486604698 | 0.00356801887614882 | 0.0275988041830569 | 0.139554890881987 |
| 68 | 68 | BRCA | ixabepilone | ARID1A | -423.75286630715 | -425.144456111965 | -422.690594905285 | 0.0075016314097617 | 0.024226708382684 | 0.123677262137495 |
| 69 | 69 | BRCA | ixabepilone | ARID1B | -409.701358623571 | -404.14271692738 | -409.366755226028 | 0.00731704232755897 | 0.00755030534816792 | 0.132094542812315 |
| 70 | 70 | BRCA | ixabepilone | BAP1 | -253.402045509173 | -253.578983148254 | -250.297044090286 | 0.00207284219974302 | 0.00389303407894892 | 0.15715926569501 |
| 71 | 71 | BRCA | ixabepilone | BARD1 | -703.986029639036 | -703.986029573487 | -701.783191856696 | 0.000986103114493546 | -0.00117626466637266 | 0.0758454175187978 |
| 72 | 72 | BRCA | ixabepilone | BRCA2 | -279.372393421017 | -283.137470936244 | -278.945944834968 | 0.00336175104537848 | 0.0128228021279581 | 0.160005850099668 |
| 73 | 73 | BRCA | ixabepilone | CASP8 | -710.829537282531 | -710.829537207189 | -710.610119241503 | 0.00091032446181478 | -0.00125220734977938 | 0.0678813269958689 |
| 74 | 74 | BRCA | ixabepilone | CCND1 | 707.888106224929 | 690.386369896436 | 738.420630649564 | 0.000264750727895834 | 0.0412008830187744 | 0.160263423953337 |
| 75 | 75 | BRCA | ixabepilone | CDH1 | -525.979895017845 | -529.171890935614 | -524.715614206438 | 0.000399700989768884 | 0.00959510799747987 | 0.111765701939411 |
| 76 | 76 | BRCA | ixabepilone | CDKN1B | -254.337611947645 | -254.565721566778 | -253.586594129316 | 0.000687220266649655 | -0.000141475909634758 | 0.126710977870007 |
| 77 | 77 | BRCA | ixabepilone | CTCF | -399.730759259453 | -399.730759222661 | -398.535176321836 | 0.000885899684289296 | -0.001276684862481 | 0.117227434420716 |
| 78 | 78 | BRCA | ixabepilone | EP300 | -341.721818071132 | -341.721818045584 | -341.189506956682 | 0.00692506215807577 | 0.00477554928850854 | 0.141916230734752 |
| 79 | 79 | BRCA | ixabepilone | ERBB2 | 823.031500666117 | 823.031500670074 | 836.17775728506 | 0.000352608022433228 | -0.0018111309133908 | 0.103721894314893 |
| 80 | 80 | BRCA | ixabepilone | ESR1 | -440.16938642023 | -434.806530341038 | -439.948550752103 | 0.00504501526714899 | 0.00535854255760415 | 0.132775427899688 |
| 81 | 81 | BRCA | ixabepilone | ETV6 | -235.033695114196 | -235.033926229905 | -233.37052634626 | 0.0020026742064644 | -0.000145122198236702 | 0.129123538773281 |
| 82 | 82 | BRCA | ixabepilone | FOXA1 | 113.678014026512 | 113.678014035807 | 118.96897698347 | 0.00623269645032022 | 0.00408168496431116 | 0.148444359075374 |
| 83 | 83 | BRCA | ixabepilone | GATA3 | -235.493490997335 | -235.493490973365 | -235.485911239271 | 8.99474869083158e-08 | -0.00216441203664597 | 0.156866910537195 |
| 84 | 84 | BRCA | ixabepilone | IKZF3 | 825.023708640176 | 825.023708644095 | 837.756491638254 | 0.000429491255645501 | -0.00173408126591879 | 0.103863556075956 |
| 85 | 85 | BRCA | ixabepilone | IRS4 | -156.805466715277 | -157.595101703524 | -156.107145577092 | 0.000510758584617969 | 0.00140368776335065 | 0.235138498729071 |
| 86 | 86 | BRCA | ixabepilone | KEAP1 | -296.757954120399 | -296.757954105327 | -295.954243205147 | 0.00258848506623035 | 0.000429585669068477 | 0.124805627828545 |
| 87 | 87 | BRCA | ixabepilone | MAP2K4 | -52.1104113031866 | -52.1104112935068 | -50.108089420887 | 0.00548034775596067 | 0.00332770780586233 | 0.159483456760751 |
| 88 | 88 | BRCA | ixabepilone | MAP3K1 | -323.566080475373 | -323.566080454453 | -323.302221998476 | 8.20364396193722e-05 | -0.00208228815075517 | 0.119345051649749 |
| 89 | 89 | BRCA | ixabepilone | MAP3K13 | -162.360092048305 | -162.161176816635 | -158.882121632807 | 0.00993554787808259 | 0.0131087169658201 | 0.159180281007971 |
| 90 | 90 | BRCA | ixabepilone | NCOR1 | 78.0228914138275 | 78.0228914226292 | 79.7601277250247 | 0.00259333701951858 | 0.00043444813419169 | 0.15790896883217 |
| 91 | 91 | BRCA | ixabepilone | NOTCH1 | -403.178059010115 | -403.178058967945 | -402.508014611956 | 0.00165095936345346 | -0.000509969312141534 | 0.133511878010585 |
| 92 | 92 | BRCA | ixabepilone | NTRK3 | -445.280059623362 | -445.205290705021 | -444.206571778655 | 0.000348032395595105 | -0.00185344684772648 | 0.113093425352425 |
| 93 | 93 | BRCA | ixabepilone | PBRM1 | -360.231143812143 | -357.967480766531 | -359.815301697164 | 0.000273364599679578 | 0.00715215858584539 | 0.154793652293024 |
| 94 | 94 | BRCA | ixabepilone | PIK3CA | -75.8209350119703 | -76.2096530343262 | -72.1131263619162 | 0.00658892247081831 | 0.0114751802804633 | 0.165560213450592 |
| 95 | 95 | BRCA | ixabepilone | PPM1D | -39.962468623899 | -40.0292454016934 | -36.0300960292015 | 0.00515524639730985 | 0.00366619369680499 | 0.127245811907422 |
| 96 | 96 | BRCA | ixabepilone | RB1 | -173.239748401381 | -173.87156888675 | -173.033968726011 | 0.00174249862190868 | 0.00222829305880268 | 0.16116147139436 |
| 97 | 97 | BRCA | ixabepilone | SALL4 | -10.8327042188862 | -11.3758948162556 | -7.88770348378687 | 0.00670432003376393 | 0.00694130745584653 | 0.225271514750435 |
| 98 | 98 | BRCA | ixabepilone | TBX3 | -668.974703152587 | -669.547135922963 | -668.923958840369 | 0.00567686624585161 | 0.00603656054515589 | 0.0824044705159971 |
| 99 | 99 | BRCA | ixabepilone | TP53 | -120.256330125401 | -120.256330113188 | -119.436666907363 | 0.00483691582248263 | 0.00268288316084508 | 0.15990883370335 |
| 100 | 100 | BRCA | docetaxel | AKT1 | -328.373193170575 | -372.165076189796 | -325.895590566414 | 7.66206583133156e-05 | 0.0487728929453517 | 0.141916084407981 |