<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE240252"><a href="/geo/query/acc.cgi?acc=GSE240252" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE240252</a></strong></td>

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<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE240252[Accession]">Query DataSets for GSE240252</a></td>

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<tr valign="top"><td>Status</td>

<td>Public on Oct 24, 2024</td>

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<tr valign="top"><td nowrap="">Title</td>

<td style="text-align: justify">Single-cell transcriptomics of pediatric Burkitt lymphoma</td>

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<tr valign="top"><td nowrap="">Organism</td>

<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td>

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<tr valign="top"><td nowrap="">Experiment type</td>

<td>Expression profiling by high throughput sequencing<br></td>

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<tr valign="top"><td nowrap="">Summary</td>

<td style="text-align: justify">Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in pediatric patients. While most patients are currently cured, a fraction of them are resistant to therapy. In order to investigate BL heterogeneity and the features distinguishing the non-responders (NR) to therapy, we analyzed pediatric EBV-negative BL specimens collected at diagnosis by single-cell (sc)-transcriptomics. Analysis of the non-tumor component revealed a predominance of immune cell infiltrates and a small representation of fibroblasts that was enriched in NR. Tumor cells displayed patient-specific features, as well as subpopulations that were common to most patients and expressed transcripts related to cell cycle, signaling pathways and cell-of-origin signatures.<br></td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

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<tr valign="top"><td nowrap="">Overall design</td>

<td style="text-align: justify">Paired single-cell transcriptomics and immunoglobulin repertoire analyses were performed on 12 sporadic EBV-negative BL specimens (11 patients), including 8 pleural or abdominal effusions and 4 nodal tumor masses, which were collected at diagnosis and frozen as viable single cell suspensions.<br></td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

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<tr valign="top"><td>Contributor(s)</td>

<td><a href="/pubmed/?term=Basso K[Author]">Basso K</a>, <a href="/pubmed/?term=Holmes AB[Author]">Holmes AB</a>, <a href="/pubmed/?term=Mussolin L[Author]">Mussolin L</a>, <a href="/pubmed/?term=Dalla-Favera R[Author]">Dalla-Favera R</a></td>

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<tr valign="top"><td nowrap="">Citation(s)</td>

<td><span class="pubmed_id" id="39424708"><!--?xml version="1.0" encoding="UTF-8"?-->

<div class="PubmedCitation"><ul><li><span class="authors">Corinaldesi C, Holmes AB, Martire G, Tosato A et al. </span><span class="title">Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance. </span><span class="source">Leukemia</span> 2025 Jan;39(1):189-198. PMID:&nbsp;<a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/39424708">39424708</a></li></ul></div>

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<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr>

<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>

<td>Aug 07, 2023</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>

<td>Oct 24, 2024</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>

<td>Riccardo Dalla-Favera</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td>

<td><a href="mailto:rd10@cumc.columbia.edu">rd10@cumc.columbia.edu</a><br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>

<td style="text-align: justify">Columbia University<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>

<td style="text-align: justify">1130 St Nicholas Avenue<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>

<td style="text-align: justify">New York</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">State/province</td>

<td style="text-align: justify">NY</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>

<td style="text-align: justify">10032</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>

<td style="text-align: justify">USA</td>

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<tr valign="top"><td nowrap="">&nbsp;</td>

<td></td>

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<tr valign="top"><td>Platforms (1)</td>

<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL24676" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL24676</a></td>

<td valign="top">Illumina NovaSeq 6000 (Homo sapiens)</td>

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