<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE292690"><a href="/geo/query/acc.cgi?acc=GSE292690" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE292690</a></strong></td>

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<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE292690[Accession]">Query DataSets for GSE292690</a></td>

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<tr valign="top"><td>Status</td>

<td>Public on Mar 26, 2025</td>

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<tr valign="top"><td nowrap="">Title</td>

<td style="text-align: justify">DNA methylation epitypes of Burkitt lymphoma with distinct molecular and clinical features</td>

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<tr valign="top"><td nowrap="">Organism</td>

<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td>

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<tr valign="top"><td nowrap="">Experiment type</td>

<td>Methylation profiling by genome tiling array<br></td>

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<tr valign="top"><td nowrap="">Summary</td>

<td style="text-align: justify">The genetic drivers of Burkitt Lymphoma (BL) have been comprehensively explored while the role of epigenetics remains unclear. Using samples from patients across four continents, we searched for sites with consistent DNA methylation changes and associations with clinical and molecular features such as Epstein-Barr virus (EBV) status and driver mutations. We identified robust methylation patterns that were not fully explained by EBV status, implying the existence of robust epitypes: HypoBL and HyperBL. The latter had distinct genomic and clinical features including global hypermethylation, a higher mutation burden, elevated aberrant somatic hypermutation, and inferior outcomes. Methylation, gene expression and mutational differences between the epitypes support a model in which each arises from a distinct cell-of-origin. These results suggest an approach for identifying BL patients with a greater risk of treatment failure and provide a basis for the exploration of new therapeutic strategies that target the unique molecular underpinnings of each group.<br></td>

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<tr valign="top"><td nowrap="">Overall design</td>

<td style="text-align: justify">Cases were accrued within the Burkitt Lymphoma Genome Sequencing Project (BLGSP) from the following sites: Uganda Cancer Institute (UCI, Uganda), Epidemiology of Burkitt’s Lymphoma in East-African Children and Minors (EMBLEM) study, at St. Mary’s Hospital, Lacor, Uganda), Children’s Oncology Group (COG, USA) sites that participated in the AALL1131 clinical trial, St. Jude Children’s Research Hospital (USA), Memorial Sloan Kettering Cancer Center (USA), Massachusetts General Hospital (USA), Belo Horizonte (Brazil), Lyon University Hospital (France), Washington University in St. Louis (USA), National Cancer Institute (USA), BC Cancer (Canada), and Robert-Bosch-Krankenhaus (Germany). Patients at the age of enrollment older than 20 years were considered adults for the purpose of this study. The study data set consisted of pediatric and adult BL patients. A total of 218 BL samples and 6 normal centroblast samples were preserved for further analysis. Additionally, 13 BL cell lines were also profiled.<br></td>

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<tr valign="top"><td>Contributor(s)</td>

<td><a href="/pubmed/?term=Thomas N[Author]">Thomas N</a>, <a href="/pubmed/?term=Garcia-Prieto CA[Author]">Garcia-Prieto CA</a>, <a href="/pubmed/?term=Dreval K[Author]">Dreval K</a>, <a href="/pubmed/?term=Hilton LK[Author]">Hilton LK</a>, <a href="/pubmed/?term=Abramson JS[Author]">Abramson JS</a>, <a href="/pubmed/?term=Bartlett NL[Author]">Bartlett NL</a>, <a href="/pubmed/?term=Bethony J[Author]">Bethony J</a>, <a href="/pubmed/?term=Bowen J[Author]">Bowen J</a>, <a href="/pubmed/?term=Bryan AC[Author]">Bryan AC</a>, <a href="/pubmed/?term=Casper C[Author]">Casper C</a>, <a href="/pubmed/?term=Dyer MA[Author]">Dyer MA</a>, <a href="/pubmed/?term=Gastier-Foster JM[Author]">Gastier-Foster JM</a>, <a href="/pubmed/?term=Gerrie AS[Author]">Gerrie AS</a>, <a href="/pubmed/?term=Greiner TC[Author]">Greiner TC</a>, <a href="/pubmed/?term=Griner NB[Author]">Griner NB</a>, <a href="/pubmed/?term=Gross TG[Author]">Gross TG</a>, <a href="/pubmed/?term=Harris NL[Author]">Harris NL</a>, <a href="/pubmed/?term=Irvin JD[Author]">Irvin JD</a>, <a href="/pubmed/?term=Jaffe ES[Author]">Jaffe ES</a>, <a href="/pubmed/?term=Leal F[Author]">Leal F</a>, <a href="/pubmed/?term=Mbulaiteye SM[Author]">Mbulaiteye SM</a>, <a href="/pubmed/?term=Mullighan CG[Author]">Mullighan CG</a>, <a href="/pubmed/?term=Mungall AJ[Author]">Mungall AJ</a>, <a href="/pubmed/?term=Mungall K[Author]">Mungall K</a>, <a href="/pubmed/?term=Namirembe C[Author]">Namirembe C</a>, <a href="/pubmed/?term=Noy A[Author]">Noy A</a>, <a href="/pubmed/?term=Ogwang MD[Author]">Ogwang MD</a>, <a href="/pubmed/?term=Orem J[Author]">Orem J</a>, <a href="/pubmed/?term=Ott G[Author]">Ott G</a>, <a href="/pubmed/?term=Petrello H[Author]">Petrello H</a>, <a href="/pubmed/?term=Reynolds SJ[Author]">Reynolds SJ</a>, <a href="/pubmed/?term=Swerdlow SH[Author]">Swerdlow SH</a>, <a href="/pubmed/?term=Traverse-Glehen A[Author]">Traverse-Glehen A</a>, <a href="/pubmed/?term=Wilson WH[Author]">Wilson WH</a>, <a href="/pubmed/?term=Marra MA[Author]">Marra MA</a>, <a href="/pubmed/?term=Staudt LM[Author]">Staudt LM</a>, <a href="/pubmed/?term=Scott DW[Author]">Scott DW</a>, <a href="/pubmed/?term=Esteller M[Author]">Esteller M</a>, <a href="/pubmed/?term=Morin RD[Author]">Morin RD</a></td>

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<tr valign="top"><td>Citation missing</td>

<td class="message" id="pmidCell">Has this study been published? Please <a href="/geo/submitter">login</a> to update or <a href="mailto:geo@ncbi.nlm.nih.gov?subject=Citation for GSE292690 [not logged in]&amp;body=Thank you very much for helping to keep GEO citation links up-to-date. Please enter the PubMed ID (PMID) or full citation for GSE292690 below, and we will update the record accordingly within the next day or two. The PubMed ID or citation is:

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<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr>

<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>

<td>Mar 23, 2025</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>

<td>Mar 26, 2025</td>

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<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>

<td>Ryan D. Morin</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>

<td style="text-align: justify">Simon Fraser University<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Department</td>

<td style="text-align: justify">Molecular Biology and Biochemistry<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Lab</td>

<td style="text-align: justify">Ryan Morin Lab<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>

<td style="text-align: justify">8888 University Drive<br></td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>

<td style="text-align: justify">Burnaby</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">State/province</td>

<td style="text-align: justify">BC</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>

<td style="text-align: justify">V5A 1S6</td>

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<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>

<td style="text-align: justify">Canada</td>

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<tr valign="top"><td>Platforms (1)</td>

<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL23976" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL23976</a></td>

<td valign="top">Illumina Infinium HumanMethylation850 BeadChip</td>

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