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+<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE269220"><a href="/geo/query/acc.cgi?acc=GSE269220" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE269220</a></strong></td>
+<td></td>
+<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE269220[Accession]">Query DataSets for GSE269220</a></td>
+</tr></tbody></table></td></tr>
+<tr valign="top"><td>Status</td>
+<td>Public on Feb 27, 2025</td>
+</tr>
+<tr valign="top"><td nowrap="">Title</td>
+<td style="text-align: justify">Comprehensive Analysis of Relapsed-Refractory Mature B-cell Non-Hodgkin Lymphoma in Children and Adolescents </td>
+</tr>
+<tr valign="top"><td nowrap="">Organism</td>
+<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td>
+</tr>
+<tr valign="top"><td nowrap="">Experiment type</td>
+<td>Genome variation profiling by SNP array<br></td>
+</tr>
+<tr valign="top"><td nowrap="">Summary</td>
+<td style="text-align: justify">Outcome of paediatric B-cell Non-Hodgkin Lymphoma (B-NHL) has significantly improved in the last decades due to risk adapted strategies and the addition of immunotherapy, (survival &gt;90%). However, limited progress has been achieved in relapsed patients, mostly Burkitt lymphoma (&lt;30%). Validation of prognostic biomarkers to identify candidates to novel therapies is imperative. This retrospective study reports on clinical and therapeutic data of 46 children and adolescents with relapsed B-NHL, including integrative molecular data of 16 (35%) cases. TP53 alterations were identified in 10 (60%) patients which were associated with worse outcome. Our data support the focus on TP53 as a potential biomarker.<br></td>
+</tr>
+<tr valign="top"><td nowrap="">&nbsp;</td>
+<td></td>
+</tr>
+<tr valign="top"><td nowrap="">Overall design</td>
+<td style="text-align: justify">Outcome of pediatric B-cell Non-Hodgkin Lymphoma (B-NHL) has significantly improved in the last decades due to risk adapted strategies and the addition of immunotherapy, (survival &gt;90%). However, limited progress has been achieved in relapsed patients, mostly Burkitt lymphoma (&lt;30%). Validation of prognostic biomarkers to identify candidates to novel therapies is imperative. This retrospective study reports on clinical and therapeutic data of 45 children and adolescents with relapsed B-NHL, including integrative molecular data of 17 (37%) cases.<br>CNAs were examined in 23 samples from 17 patients (from 8 patients available at diagnosis, 5 patients with paired samples, and 5 patients with only relapse samples). using Oncoscan (22 samples) or Cytoscan (1 sample) platforms (ThermoFisher Scientific, Waltham, MA, USA) according to standard protocols. Gains and losses and regions of CN neutral loss of heterozygosity (CNN-LOH) were evaluated using Nexus Biodiscovery v9.0 software (Biodiscovery, Hawthorne, CA, USA).<br>CNAs were identified in all investigated samples. Median CNAs was 5.5 at diagnosis (range 0–19) and 7 at relapse (range 1–88). No differences were observed in terms of genomic complexity between diagnosis and relapse (mean 6.9 vs 16 CNA/case, p-value 0.47), nor between our R/R series and B-NHL series not enriched in relapse cases. We investigated the CN profile of the 17 patients with available material. Recurrent CNAs (&gt;20%) included 1q21.1-q25.3, and 13q31.3 gains, and 4p16.3, 4q34.3-q35.3, 9q21.3-q22.32, 17p13.1-p11.2/TP53, and Yp11.31-q11.23 losses. CNN-LOH of 17p13.3-p11.2 including TP53 were also recurrent, affecting 29% of the patients.<br></td>
+</tr>
+<tr valign="top"><td nowrap="">&nbsp;</td>
+<td></td>
+</tr>
+<tr valign="top"><td>Contributor(s)</td>
+<td><a href="/pubmed/?term=Mato S[Author]">Mato S</a>, <a href="/pubmed/?term=Salaverria I[Author]">Salaverria I</a></td>
+</tr>
+<tr valign="top"><td nowrap="">Citation(s)</td>
+<td><span class="pubmed_id" id="40011029"><!--?xml version="1.0" encoding="UTF-8"?-->
+<div class="PubmedCitation"><ul><li><span class="authors">Mato S, Carità L, Colmenero A, Andrés M et al. </span><span class="title">Comprehensive analysis of relapsed-refractory mature B-cell non-Hodgkin lymphoma in children and adolescents. </span><span class="source">Br J Haematol</span> 2025 Feb 26. PMID:&nbsp;<a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/40011029">40011029</a></li></ul></div>
+</span></td>
+</tr>
+<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr>
+<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td>
+<td>Jun 06, 2024</td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td>
+<td>Feb 28, 2025</td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td>
+<td>Itziar Salaverria</td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td>
+<td><a href="mailto:isalaver@clinic.cat">isalaver@clinic.cat</a><br></td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td>
+<td style="text-align: justify">Hospital Clínic<br></td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td>
+<td style="text-align: justify">Rossello 153<br></td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td>
+<td style="text-align: justify">Barcelona</td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td>
+<td style="text-align: justify">08036</td>
+</tr>
+<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td>
+<td style="text-align: justify">Spain</td>
+</tr>
+<tr valign="top"><td nowrap="">&nbsp;</td>
+<td></td>
+</tr>
+<tr valign="top"><td>Platforms (2)</td>
+<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL16131" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL16131</a></td>
+<td valign="top">[CytoScanHD_Array] Affymetrix CytoScan HD Array</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL18602" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL18602</a></td>
+<td valign="top">[OncoScan] Affymetrix OncoScan FFPE Assay</td>
+</tr>
+</tbody></table></td>
+</tr>
+<tr valign="top"><td>Samples (23)<div id="L1500440383divshown" name="L1500440383divshown" style="display: none"><a href="javascript:HandleVisibilityChangeL1500440383()"><img alt="Less..." border="0" src="/geo/img/minus_close.gif">&nbsp;Less...</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</div>
+<div id="L1500440383divhidden" name="L1500440383divhidden" style="display: block"><a href="javascript:HandleVisibilityChangeL1500440383()"><img alt="More..." border="0" src="/geo/img/plus_small.gif">&nbsp;More...</a></div>
+</td>
+<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308836" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308836</a></td>
+<td valign="top">Aggressive B-cell lymphoma R7D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308837" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308837</a></td>
+<td valign="top">Aggressive B-cell lymphomaR10D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308838" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308838</a></td>
+<td valign="top">Aggressive B-cell lymphomaR21D</td>
+</tr>
+</tbody></table>
+<script language="Javascript" type="text/javascript">
+<!--
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+</script>
+<div id="L1500440383div" name="L1500440383div" style="display: none"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308839" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308839</a></td>
+<td valign="top">Aggressive B-cell lymphomaR22D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308840" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308840</a></td>
+<td valign="top">Aggressive B-cell lymphoma R24D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308841" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308841</a></td>
+<td valign="top">Aggressive B-cell lymphoma R26R1</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308842" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308842</a></td>
+<td valign="top">Aggressive B-cell lymphoma R27R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308843" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308843</a></td>
+<td valign="top">Aggressive B-cell lymphoma R29D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308844" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308844</a></td>
+<td valign="top">Aggressive B-cell lymphoma R29R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308845" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308845</a></td>
+<td valign="top">Aggressive B-cell lymphoma R31D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308846" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308846</a></td>
+<td valign="top">Aggressive B-cell lymphoma R32D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308847" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308847</a></td>
+<td valign="top">Aggressive B-cell lymphoma R35R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308848" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308848</a></td>
+<td valign="top">Aggressive B-cell lymphoma R36D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308849" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308849</a></td>
+<td valign="top">Aggressive B-cell lymphoma R36R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308850" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308850</a></td>
+<td valign="top">Aggressive B-cell lymphoma R37R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308851" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308851</a></td>
+<td valign="top">Aggressive B-cell lymphoma R44D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308852" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308852</a></td>
+<td valign="top">Aggressive B-cell lymphoma R44R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308853" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308853</a></td>
+<td valign="top">Aggressive B-cell lymphoma R44R2</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308854" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308854</a></td>
+<td valign="top">Aggressive B-cell lymphoma R46R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308855" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308855</a></td>
+<td valign="top">Aggressive B-cell lymphoma R48D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308856" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308856</a></td>
+<td valign="top">Aggressive B-cell lymphoma R53D</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308857" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308857</a></td>
+<td valign="top">Aggressive B-cell lymphoma R53R</td>
+</tr>
+<tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GSM8308858" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GSM8308858</a></td>
+<td valign="top">Aggressive B-cell lymphoma R31R</td>
+</tr>
+</tbody></table></div>
+</td>
+</tr>
+<tr valign="top"><td colspan="2"><strong>Relations</strong></td></tr>
+<tr valign="top"><td>BioProject</td>
+<td><a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1120752">PRJNA1120752</a></td>
+</tr>
+</tbody></table>
+<br><span id="gdv"></span><table cellspacing="3" width="600"><tbody><tr bgcolor="#eeeeee"><td><strong>Download family</strong></td>
+<td><strong>Format</strong></td>
+</tr>
+<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269220/soft/" target="_blank">SOFT formatted family file(s)</a></td>
+<td>SOFT<a href="javascript:RPopUpWindow_Set(geoaxema_famsoft,260,120,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td>
+</tr>
+<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269220/miniml/" target="_blank">MINiML formatted family file(s)</a></td>
+<td>MINiML<a href="javascript:RPopUpWindow_Set(geoaxema_famminiml,260,120,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td>
+</tr>
+<tr><td><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269220/matrix/" target="_blank">Series Matrix File(s)</a></td>
+<td>TXT<a href="javascript:RPopUpWindow_Set(geoaxema_fammatrix,260,210,'','','#E1EAE6','','#538AA9','MessageBox2');" onmouseout="RPopUpWindow_Stop()"><img alt="Help" height="11" src="/coreweb/images/long_help4.gif" style="border: none" width="19"></a></td>
+</tr>
+</tbody></table>
+<br><table cellpadding="2" cellspacing="2" width="600"><tbody><tr bgcolor="#eeeeee" valign="top"><td align="middle" bgcolor="#CCCCCC"><strong>Supplementary file</strong></td>
+<td align="middle" bgcolor="#CCCCCC"><strong>Size</strong></td>
+<td align="middle" bgcolor="#CCCCCC"><strong>Download</strong></td>
+<td align="middle" bgcolor="#CCCCCC"><strong>File type/resource</strong></td>
+</tr>
+<tr valign="top"><td bgcolor="#DEEBDC">GSE269220_CN_START_ENDS.xlsx</td>
+<td bgcolor="#DEEBDC" title="34988">34.2 Kb</td>
+<td bgcolor="#DEEBDC"><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269220/suppl/GSE269220%5FCN%5FSTART%5FENDS%2Exlsx">(ftp)</a><a href="/geo/download/?acc=GSE269220&amp;format=file&amp;file=GSE269220%5FCN%5FSTART%5FENDS%2Exlsx">(http)</a></td>
+<td bgcolor="#DEEBDC">XLSX</td>
+</tr>
+<tr valign="top"><td bgcolor="#EEEEEE">GSE269220_RAW.tar</td>
+<td bgcolor="#EEEEEE" title="700211200">667.8 Mb</td>
+<td bgcolor="#EEEEEE"><a href="/geo/download/?acc=GSE269220&amp;format=file">(http)</a><a id="customDl" href="">(custom)</a></td>
+<td bgcolor="#EEEEEE">TAR (of CEL, CYCHP, OSCHP)</td>
+</tr>
+</tbody></table>
+<span id="customDlArea"></span><br></td></tr></tbody></table>
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